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Case Report
- A Case of a Young Woman with Hepatosplenic gamadelta T-cell Lymphoma
- Il Gwon Park, Cheol Won Suh, Joo Ryung Hur, Sun Jong Kim, Keon Uk Park, Seong Je Park, Don Dae Seo, Man Su Ahn, Geun Doo Jang, Woo Kun Kim
- Cancer Res Treat. 2001;33(3):264-268. Published online June 30, 2001
- DOI: https://doi.org/10.4143/crt.2001.33.3.264
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Abstract
PDF - Most T-cell lymphomas arise from mature alpabeta T-cells and commonly involve the nodes. Lymphomas bearing the gamadelta T-cell receptor (TCR) are very rare, and involve the lymph nodes minimally, if at all. Hepatosplenic gamadelta T-cell lymphoma is a recently identified, rare entity in which lymphoma cells bearing the gamadelta TCR infiltrate the sinusoids of the liver, splenic red pulp, and bone marrow. Its leukemic transformation is even more rare. Recently, we experienced a case of hepatosplenic gamadelta T-cell lymphoma in a 19-year-old woman who presented with epigastric pain, fever, massive splenomegaly, andpancytopenia. The splenectomy specimen and excisional biopsy of the liver revealed the infiltration of atypical T lymphocytes with the immunophenotypic markers of CD3 (+), CD45RO (pan-T antigen) (+), TIA-1(+), CD4(-),CD8 (-), CD56 (-), and S100 (-) in the sinusoids of the liver and splenic red pulp. Polymerase chain reaction (PCR) showed that these cells had the expression of the TCR gama gene rearrangements. Though the pancytopenia had improved after the splenectomy, the response of chemotherapy was transient. Her disease progressed rapidly and she expired in the leukemic phase. We report a case of hepatosplenic gamadelta T-cell lymphoma that developed in a young woman, along with a brief review of the literature.
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Citations
Citations to this article as recorded by
- Hepatosplenic T cell lymphoma: a unifying entity in a patient with hemolytic anemia, massive splenomegaly, and liver dysfunction
Marianna Mavilia, Agnes McAuliffe, Safina Hafeez, Haleh Vaziri
Clinical Journal of Gastroenterology.2018; 11(5): 364. CrossRef - A Case of Hepatosplenic T-cell Lymphoma Diagnosed by Bone Marrow Examination
Hee Jin So, Jin Kyung Lee, Young Jun Hong, Seok-Il Hong, Hye Jin Kang, Seung-Sook Lee, Yoon Hwan Chang
Laboratory Medicine Online.2013; 3(2): 104. CrossRef - A Case of Hepatosplenic T-cell Lymphoma with Colonic Involvement
Ji Young Choi, Hye Sun Park, Dong Soo Han, Jae Hoon Kim, Yil Sik Hyun, Joong Ho Bae, Chang Soo Eun, Young Ha Oh
Intestinal Research.2011; 9(1): 51. CrossRef - A Case of Successful Allogeneic Stem Cell Transplantation for Chemotherapy-refractory Hepatosplenic γ δ-T Cell Lymphoma
Sung Bin Kim, Su Hyeon Jeong, Jin Hee Park, Hye Soo Kim, Bu Kyung Kim, Ho Sup Lee
The Korean Journal of Hematology.2009; 44(4): 284. CrossRef
- Hepatosplenic T cell lymphoma: a unifying entity in a patient with hemolytic anemia, massive splenomegaly, and liver dysfunction
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