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Original Articles
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Thymic Carcinoma: Report of Eight Cases
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Young Don Joo, Joon Hee Kim, Chang Hak Son, Ye Hoe Kim, Chan Hwan Kim, Hyun Sook Seo
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J Korean Cancer Assoc. 1998;30(4):743-751.
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Abstract
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- Thymic carcinoma is a rare malignant neoplasm of the thymic epithelium, distinguished from benign or invasive thymoma by the presence of malignant cytology and a greater incidence of local invasion and embolic metastases. The true incidence of this neoplasm is unknown. Nearly three fourth of their patients had symptoms of an anterior mediastinal mass, including cough, chest pain, and superior vena cava syndrome. These patients rarely have myasthenia gravis or other thymoma-associated paraneoplastic syndromes. The treatment of thymic carcinoma remains a controversial matter. We report eight cases of thymic carcinoma treated in our institution from 1990 to 1997.
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A Case of Well - Differentiated Thymic Carcinoma with Severe Aplastic Anemia
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Jung Ah Kim, Gi Hyeon Seo, Sung Soo Yoon, Won Ki Kang, Hong Ghi Lee, Keun Chil Park, Young Hyeh Ko, Chan Hyung Park
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J Korean Cancer Assoc. 1996;28(5):897-903.
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Abstract
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- Thymoma is occasionally associated with hematologic disorders such as pure red cell aplasia, agranulocytosis, and thrombocytopenia and several cases have been associated with pancytopenia. In contrast, thymic carcinoma has rarely been associated with aplastic anemia except one case reported by Thomas et aL. This case report concerns a patient in whom we have observed simultaneous occurrence of a well differentiated thymic carcinoma and a severe marrow aplasia for which we describe our therapeutic approach. Our patient did not benefit from thymectomy. We then tried antilymphocyte globulin and cyclosporine and the patient had a partial response with hematologic improvements.
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