Cancer Research and Treatment

Case Report

Orbital Infiltration as the First Site of Relapse of Primary Testicular T-cell Lymphoma: Hyun Jung Jun, Won Seog Kim, Ji Hyun Yang, Seong Yoon Yi, Young H. Ko, Jeeyun Lee, Chul Won Jung, Se Woong Kang, Keunchil Park; Cancer Res Treat. 2007;39(1):40-43. Published online March 31, 2007; DOI: https://doi.org/10.4143/crt.2007.39.1.40

A 43-year-old male presented with a painless left testicular mass. The pathologic diagnosis of the radical orchiectomy specimen was peripheral T-cell lymphoma, unspecified (PTCL-u). According to the Ann Arbor staging system, his initial stage was III because of the right nasopharyngeal involvement. After first-line chemotherapy with four courses of the CHOP regimen and this was followed by involved-field radiotherapy, he achieved complete remission. Two months later, disease recurred to the left ciliary body of the left eye without evidence of involvement at other sites. Although the patient received intensive chemotherapy with autologous hematopoietic stem cell transplantation, he ultimately died of leptomeningeal seeding. Because both the central nervous system (CNS) and the orbit are sanctuary sites for chemotherapy, orbital infiltration of lymphoma should prompt physicians to evaluate involvement of the CNS and to consider performing prophylactic intrathecal chemotherapy as a treatment option.

Citations

Citations to this article as recorded by

Relapse of Ocular Lymphoma following Primary Testicular Diffuse Large B-cell Lymphoma
Hye Ji Kwon, Joo Yong Lee
Journal of Retina.2023; 8(1): 58. CrossRef
Chronic lymphocytic leukemia and concurrent seminoma in the same testis
Kosuke Miyai, Fumihisa Kumazawa, Kimiya Sato, Hitoshi Tsuda
Journal of Pathology and Translational Medicine.2022; 56(1): 48. CrossRef
Diagnosis, prevention and treatment of central nervous system involvement in peripheral t-cell lymphomas
Natalia Zing, Thais Fischer, Massimo Federico, Carlos Chiattone, Andrés J.M. Ferreri
Critical Reviews in Oncology/Hematology.2021; 167: 103496. CrossRef
Primary testicular T-lymphoblastic lymphoma in a child
Yongren Wang, Jian Li, Yongjun Fang
Medicine.2020; 99(26): e20861. CrossRef
Peripheral T-Cell Lymphoma, Not Otherwise Specified and Concurrent Seminoma in Testis
Junichi Kitagawa, Naoe Goto, Yuhei Shibata, Nobuhiko Nakamura, Hiroshi Nakamura, Nobuhiro Kanemura, Takeshi Hara, Katsuyoshi Takata, Yasuharu Sato, Tadashi Yoshino, Hisashi Tsurumi
Journal of Clinical and Experimental Hematopathology.2015; 55(3): 169. CrossRef
Primary testicular lymphoma
Chan Y. Cheah, Andrew Wirth, John F. Seymour
Blood.2014; 123(4): 486. CrossRef
Testicular lymphoma, intraocular (Vitreoretinal) lymphoma, and brain lymphoma: Involvement of three immunoprivileged sites in one patient
Jacob Pe'er, Jacob M. Rowe, Shahar Frenkel, Eldad J. Dann
American Journal of Hematology.2010; 85(8): 631. CrossRef

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Original Article

Determination of Chromosomal Alterations in Nasal NK/T-cell Lymphomas by DOP-PCR and Comparative Genomic Hybridization: Sang Jin Park, Mahn Joon Ha, Hyon Ju Kim, Kwang Hwa Park, Hyun Soo Kim, Woo Ik Yang, Hugh Chul Kim; J Korean Cancer Assoc. 2000;32(3):578-586.

Abstract PDF: PURPOSE
Because of difficulty of obtaining metaphase cells from tumor specimens, there are only a few cytogenetic studies in nasal NK/T-cell lymphomas, and so far no consistent specific chromosomal abnormalities have been described. In this study, we have used degenerate oligonucleotide primed PCR (DOP-PCR) and comparative genomic hybridization (CGH) to deter mine chromosomal alterations from 6 nasal NK/T-cell lymphoma tissues dissected from formalin- fixed paraffin-embedded slide sections.
MATERIALS AND METHODS
For the isolation of tumor DNA, four 7-micrometer-thick tissue sections from each sample were dewaxed and rehydrated, and areas of high tumor cell content (more than 60%) were dissected and pooled into a tube. Normal DNA was prepared from the peripheral blood of a healthy volunteer. Tumor DNA was labeled with biotin-16-dUTP by DOP-PCR and normal DNA was labeled with digoxigenin-dUTP using a nick translation kit. In CGH, equal amounts of differently labeled DNA from the tumors and normal reference DNA were hybridized simul taneously to normal metaphase chromosomes. They were visualized by different fluordegrees Chromes, and the signal intensities were quantitated separately as gray levels for each chromosome. The over- and underrepresented DNA segments were determined by computation of image ratios and average ratio profiles.
RESULTS
Our results show that gains of DNA copy number were more prevalence than DNA losses. The most commonly observed gains were mapped to chromosomal regions of 1p32.2 ter,19 and 20 in 4 of 6 cases (67%). The other frequent gains were found on chromosomes 12q in 3 of 6 cases. The most frequent loss was detected on 6q in 4 of 6 cases(67%), and less fre quently observed on 13q21.1 q34 and 13q14 q34.
CONCLUSION
These genomic changes found in specific chromosomal regions are likely to harbor genes of importance in nasal NK/T-cell lymphomagenesis, therefore such cytogenetic mapping of genomic imbalance may be of value for further molecular delineation of NK/T-cell lymphoma.

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