Accurate prediction of impending death (i.e., last few days of life) is essential for terminally-ill cancer patients and their families. International guidelines state that clinicians should identify patients with impending death, communicate the prognosis with patients and families, help them with their end-of-life decision-making, and provide sufficient symptom palliation. Over the past decade, several national and international studies have been conducted that systematically investigated signs and symptoms of impending death as well as how to communicate such a prognosis effectively with patients and families. In this article, we summarize the current evidence on prognostication and communication regarding the last days of life of patients with cancer, and future directions of clinical research.
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Corneal reflex: novel strong prognostic marker for imminent death Se-Il Go, Gyeong-Won Lee, Byeong Sun Moon, Jung Woo Choi, Seong-Je Kim, Jung Hun Kang BMJ Supportive & Palliative Care.2026; 16(2): 466. CrossRef
A Modified Trigger Tool for Identification of Patient Harm in Palliative Care Patients. A Pilot Study From Norway Espen Klingenberg, Anne K. Lindahl, Kathrine Brenne, Milada Hagen, Olav M.S. Fredheim Journal of Patient Safety.2026; 22(3): 199. CrossRef
Monitoring patients’ symptom improvement in palliative care units using patient-reported outcomes: a multicenter prospective observational study Natsuko Katsube, Akihiro Sakashita, Kyoko Kamohara, Kousei Adachi, Ritsuko Yabuki, Akira Inoue, Mamiko Sato, Syun Koike, Hirofumi Abo, Kento Masukawa, Yasuo Shima, Mitsunori Miyashita BMC Palliative Care.2026;[Epub] CrossRef
Recognizing and Predicting the Syndrome of Imminent Death (≤14 Days): A Systematic Review Bernardo Rocha-Baião, Paulo Reis-Pina Journal of Pain and Symptom Management.2026; 71(6): e671. CrossRef
The Effect of Moral Injury Symptoms of Intensive Care Nurses on their Attitudes and Behaviors Towards End-of-Life Care: A Cross-Sectional and Analytical Study in Turkey Kerime Hacıköylü Doğan, Fatma Özkan Tuncay Journal of Religion and Health.2026; 65(2): 1428. CrossRef
The characteristics of patients’ medical care, living will, and signs of death by age and the place of death: A cross-sectional study using a questionnaire survey targeting physicians with expertise in end-of-life care Mitsutaka Yakabe, Tatsuya Hosoi, Shoya Matsumoto, Shoho Miura, Kazuhiro Hoshi, Soichiro Iwao, Yoshihiro Kitamura, Masahiro Akishita, Sumito Ogawa, Sascha Köpke PLOS One.2026; 21(3): e0343868. CrossRef
Bedside Neurological Signs of Impending Death in Terminal Cancer Patients Receiving Home Hospice Care Kunihiko Watanabe, Kumi Tochimura, Hiromi Fujita, Yukie Kushima, Kazuhiko Kushima, Yuki Kamiyama, Akemi Hemmi American Journal of Hospice and Palliative Medicine®.2026;[Epub] CrossRef
Case report: Poor prognosis or poor prognostication? Jacqueline Tschanz, Rida Khan, Eduardo Bruera Palliative and Supportive Care.2025;[Epub] CrossRef
Effectiveness of palliative postural care in alleviating pain and psychological distress in terminal cancer patients Jia Fu, Yu Liu, Mei Zhang, Lili He Asian Journal of Surgery.2025; 48(5): 3253. CrossRef
Determining timeframes to death for imminently dying patients: a retrospective cohort study Tricia O’Connor, Wai-Man Liu, Juliane Samara, Joanne Lewis, Karen Strickland, Catherine Paterson BMC Palliative Care.2025;[Epub] CrossRef
High specificity clinical signs of impending death: A scoping review Catarina Simões, Rui Carneiro, Abílio CardosoTeixeira International Journal of Nursing Studies.2025; 164: 105015. CrossRef
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Prognostication in advanced cancer: foreseeing from global insights and foretelling in the Asian context Yusuke Hiratsuka, Jun Hamano, Masanori Mori, Sang-Yeon Suh, David Hui Japanese Journal of Clinical Oncology.2025; 55(9): 991. CrossRef
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