Cancer Research and Treatment

Original Articles

Phase II Trial of Neoadjuvant Docetaxel/Cisplatin/5-Fluorouracil Combined with Pegteograstim for Unresectable, Locally Advanced Sinonasal Squamous Cell Carcinoma: KCSG HN18-07: Bhumsuk Keam, Ho Jung An, Seong Hoon Shin, Min Kyoung Kim, Jung Hae Cho, Seyoung Seo, Sung-Bae Kim; Received October 24, 2024 Accepted December 13, 2024 Published online December 16, 2024; DOI: https://doi.org/10.4143/crt.2024.1025 [Accepted]

Abstract PDF: Purpose
The role of neoadjuvant chemotherapy in locally advanced sinonasal squamous cell carcinoma (SNSCC) has not been established prospectively. We conducted a phase II trial of neoadjuvant chemotherapy (NAC) with docetaxel/cisplatin/5-fluorouracil (TPF) in this population.
Materials and Methods
Eligible patients had unresectable, locally advanced SNSCC, defined as T3/4 stage or potential compromise of critical organ function on surgery. Three TPF (docetaxel 75 mg/m² and cisplatin 75 mg/m² on day 1, 5-fluorouracil 1,000 mg/m² on days 1–4 every 3 weeks) cycles were administered with prophylactic pegteograstim. The primary outcome was the overall response rate (ORR); the secondary outcomes included 2-year progression-free survival (PFS), eyeball preservation rate, and safety.
Results
Among 28 patients screened, 25 were evaluable for efficacy (one screen-failure; two evaluable for safety only). The confirmed ORR was 72.0%. The definitive post-NAC treatment comprised chemoradiotherapy (n=15) and surgery (n=10). With a median follow-up of 25.5 months, median PFS was not reached and the 2-year PFS rate was 60.4%. Response to NAC was related to prolonged PFS (p=0.038). No patient underwent eyeball exenteration at the data cutoff point. Treatment-related adverse events of grade ≥3 were neutropenia (48.1%) including febrile neutropenia (14.8%), followed by acute kidney injury (22.2%), nausea/vomiting (11.1%), anemia (7.4%), thrombocytopenia (7.4%), and enterocolitis (3.7%).
Conclusion
TPF NAC showed a promising efficacy and might help preserve critical structures in this population, which needs to be validated in a large prospective trial (KCT0003377).

562 View
53 Download

Lung and Thoracic cancer

The Role of Neutrophil-to-Lymphocyte Ratio in Predicting Pathological Response for Resectable Non–Small Cell Lung Cancer Treated with Neoadjuvant Chemotherapy Combined with PD-1 Checkpoint Inhibitors: Xiaoyan Sun, Yingnan Feng, Bin Zhang, Wuhao Huang, Xiaoliang Zhao, Hua Zhang, Dongsheng Yue, Changli Wang; Cancer Res Treat. 2022;54(4):1017-1029. Published online November 23, 2021; DOI: https://doi.org/10.4143/crt.2021.1007

Abstract PDF PubReader ePub

Purpose
The aim of our study was to investigate the value of baseline and preoperative neutrophil-to-lymphocyte ratio (NLR) in predicting the pathological response and disease-free survival (DFS) of neoadjuvant chemotherapy alone or combined with programmed cell death-1 (PD-1) checkpoint inhibitors in patients with resectable non‒small cell lung cancer (NSCLC).
Materials and Methods
Resectable NSCLC patients who underwent neoadjuvant chemotherapy alone or combined with PD-1 checkpoint inhibitors between January 2018 and January 2020 were included. Peripheral venous blood samples of the patients were collected within 3 days prior to the first neoadjuvant treatment and within 3 days prior to surgery.
Results
A total of 79 patients in neoadjuvant chemotherapy combined with PD-1 checkpoint inhibitors group and 89 patients in neoadjuvant chemotherapy alone group were included. Thirty-five point four percent of the patients achieved pathological complete response (pCR) in neoadjuvant chemotherapy combined with PD-1 checkpoint inhibitors group, whereas only 9.0% reached pCR in the group of neoadjuvant chemotherapy. High NLR level were correlated with poor pathological response and DFS in neoadjuvant chemotherapy or combined with PD-1 checkpoint inhibitors group. Multivariate analysis revealed that baseline NLR could independently predict pathological response and DFS in the neoadjuvant chemotherapy combined with PD-1 checkpoint inhibitors group.
Conclusion
High NLR level were correlated with poor pathological response and shorter DFS in patients with NSCLC undergoing neoadjuvant chemotherapy or combined with PD-1 checkpoint inhibitors. Meanwhile, baseline NLR could independently predict response to pathological response and DFS, revealing its potential as a screening tool in NSCLC patients who received neoadjuvant chemotherapy combined with PD-1 checkpoint inhibitors.

Citations

Citations to this article as recorded by

Perioperative inflammatory index differences between pulmonary squamous cell carcinoma and adenocarcinoma and their prognostic implications
Yi Liu, Songping Cui, Jing Wang, Bin Hu, Shuo Chen
Frontiers in Oncology.2025;[Epub] CrossRef
Circulating biomarkers as predictors of response to immune checkpoint inhibitors in NSCLC: Are we on the right path?
Calogera Claudia Spagnolo, Francesco Pepe, Giuliana Ciappina, Francesco Nucera, Paolo Ruggeri, Andrea Squeri, Desirèe Speranza, Nicola Silvestris, Umberto Malapelle, Mariacarmela Santarpia
Critical Reviews in Oncology/Hematology.2024; 197: 104332. CrossRef
Easily applicable predictive score for MPR based on parameters before neoadjuvant chemoimmunotherapy in operable NSCLC: a single-center, ambispective, observational study
Mingming Hu, Xiaomi Li, Haifeng Lin, Baohua Lu, Qunhui Wang, Li Tong, Hongxia Li, Nanying Che, Shaojun Hung, Yi Han, Kang Shi, Chenghai Li, Hongmei Zhang, Zhidong Liu, Tongmei Zhang
International Journal of Surgery.2024; 110(4): 2275. CrossRef
Dynamics of peripheral blood inflammatory index predict tumor pathological response and survival among patients with locally advanced non-small cell lung cancer who underwent neoadjuvant immunochemotherapy: a multi-cohort retrospective study
Wenyu Zhai, Chao Zhang, Fangfang Duan, Jingdun Xie, Shuqin Dai, Yaobin Lin, Qihang Yan, Bingyu Rao, Liang Li, Yuheng Zhou, Zerui Zhao, Hao Long, Junye Wang
Frontiers in Immunology.2024;[Epub] CrossRef
Predicting Pathologic Complete Response in Locally Advanced Rectal Cancer with [68Ga]Ga-FAPI-04 PET, [18F]FDG PET, and Contrast-Enhanced MRI: Lesion-to-Lesion Comparison with Pathology
Xiao Zhang, Zhenyu Lin, Yuan Feng, Zhaoguo Lin, Kaixiong Tao, Tao Zhang, Xiaoli Lan
Journal of Nuclear Medicine.2024; 65(10): 1548. CrossRef
Radiomics nomogram combined with clinical factors for predicting pathological complete response in resectable esophageal squamous cell carcinoma
Zihao Lu, Yongsen Li, Wenxuan Hu, Yonghao Cao, Xin Lv, Xinyu Jia, Shiyu Shen, Jun Zhao, Chun Xu
Frontiers in Oncology.2024;[Epub] CrossRef
Explainable Machine Learning Predictions for the Benefit From Chemotherapy in Advanced Non‐Small Cell Lung Cancer Without Available Targeted Mutations
Zhao Shuang, Xiong Xingyu, Cheng Yue, Yu Mingjing
The Clinical Respiratory Journal.2024;[Epub] CrossRef
Mean platelet volume/platelet count ratio in combination with tumor markers in colorectal cancer: a retrospective clinical study
Huan Zhang, Fan Lin, Zhuocai Wang
BMC Cancer.2023;[Epub] CrossRef
Development and validation of a radiomics-based nomogram for predicting a major pathological response to neoadjuvant immunochemotherapy for patients with potentially resectable non-small cell lung cancer
Chaoyuan Liu, Wei Zhao, Junpeng Xie, Huashan Lin, Xingsheng Hu, Chang Li, Youlan Shang, Yapeng Wang, Yingjia Jiang, Mengge Ding, Muyun Peng, Tian Xu, Ao’ran Hu, Yuda Huang, Yuan Gao, Xianling Liu, Jun Liu, Fang Ma
Frontiers in Immunology.2023;[Epub] CrossRef
Prognostic role of preoperative inflammatory markers in postoperative patients with colorectal cancer
Zilong Xiao, Xinxin Wang, Xiaoxiao Chen, Jiawei Zhou, Haitao Zhu, Jiangnan Zhang, Wensheng Deng
Frontiers in Oncology.2023;[Epub] CrossRef
Pan-Immune-Inflammatory Value in Patients with Non-Small-Cell Lung Cancer Undergoing Neoadjuvant Immunochemotherapy
Wen-Yu Zhai, Fang-Fang Duan, Yao-Bin Lin, Yong-Bin Lin, Ze-Rui Zhao, Jun-Ye Wang, Bing-Yu Rao, Lie Zheng, Hao Long
Journal of Inflammation Research.2023; Volume 16: 3329. CrossRef
The predictive value of 18F-FDG PET/CT combined with inflammatory index for major pathological reactions in resectable NSCLC receiving neoadjuvant immunochemotherapy
Xiaoqin Yin, Jian Li, Bei Chen, Kehuang Liu, Shuo Hu
Lung Cancer.2023; 186: 107389. CrossRef
Efficacy, safety, and survival of neoadjuvant immunochemotherapy in operable non-small cell lung cancer: a systematic review and meta-analysis
Yue Zheng, Baijie Feng, Jingyao Chen, Liting You
Frontiers in Immunology.2023;[Epub] CrossRef
Emerging Blood-Based Biomarkers for Predicting Immunotherapy Response in NSCLC
Ana Oitabén, Pablo Fonseca, María J. Villanueva, Carme García-Benito, Aida López-López, Alberto Garrido-Fernández, Clara González-Ojea, Laura Juaneda-Magdalena, Martín E. Lázaro, Mónica Martínez-Fernández
Cancers.2022; 14(11): 2626. CrossRef

5,758 View
222 Download
13 Web of Science
14 Crossref

Gynecologic cancer

A Preoperative Nomogram for Predicting Chemoresistance to Neoadjuvant Chemotherapy in Patients with Locally Advanced Cervical Squamous Carcinoma Treated with Radical Hysterectomy: Zhengjie Ou, Dan Zhao, Bin Li, Yating Wang, Shuanghuan Liu, Yanan Zhang; Cancer Res Treat. 2021;53(1):233-242. Published online September 14, 2020; DOI: https://doi.org/10.4143/crt.2020.159

Abstract PDF PubReader ePub

Purpose
This study aimed to investigate the factors associated with chemoresistance to neoadjuvant chemotherapy (NACT) followed by radical hysterectomy (RH) and construct a nomogram to predict the chemoresistance in patients with locally advanced cervical squamous carcinoma (LACSC).
Materials and Methods
This retrospective study included 516 patients with International Federation of Gynecology and Obstetrics (2003) stage IB2 and IIA2 cervical cancer treated with NACT and RH between 2007 and 2017. Clinicopathologic data were collected, and patients were assigned to training (n=381) and validation (n=135) sets. Univariate and multivariate analyses were performed to analyze factors associated with chemoresistance to NACT. A nomogram was built using the multivariate logistic regression analysis results. We evaluated the discriminative ability and accuracy of the model using a concordance index and a calibration curve. The predictive probability of chemoresistance to NACT was defined as > 34%.
Results
Multivariate analysis confirmed menopausal status, clinical tumor diameter, serum squamous cell carcinoma antigen level, and parametrial invasion on magnetic resonance imaging before treatment as independent prognostic factors associated with chemoresistance to NACT. The concordance indices of the nomogram for training and validation sets were 0.861 (95% confidence interval [CI], 0.822 to 0.900) and 0.807 (95% CI, 0.807 to 0.888), respectively. Calibration plots revealed a good fit between the modelpredicted probabilities and actual probabilities (Hosmer-Lemeshow test, p=0.597). Furthermore, grouping based on the nomogram was associated with progression-free survival.
Conclusion
We developed a nomogram for predicting chemoresistance in LACSC patients treated with RH. This nomogram can help physicians make clinical decisions regarding primary management and postoperative follow-up of the patients.

Citations

Citations to this article as recorded by

Neoadjuvant chemotherapy with carboplatin and paclitaxel in pregnant women with advanced stage cervical cancer: Maternal and perinatal outcomes
Bruna Elias Parreira Lopes Ferraz, Roney César Signorini Filho, Lucas Ribeiro Borges Carvalho, Michelle Samora Almeida, Tatiana Carvalho de Souza Bonetti, Edward Araujo Júnior, Antonio Braga, Sue Yazaki Sun
Journal of Gynecology Obstetrics and Human Reproduction.2025; 54(2): 102890. CrossRef
Are biomarkers expression and clinical-pathological factors predictive markers of the efficacy of neoadjuvant chemotherapy for locally advanced cervical cancer?
Antonino Ditto, Mariangela Longo, Giulia Chiarello, Luigi Mariani, Biagio Paolini, Umberto Leone Roberti Maggiore, Fabio Martinelli, Giorgio Bogani, Francesco Raspagliesi
European Journal of Surgical Oncology.2024; 50(6): 108311. CrossRef
A Deep Learning Radiomics Nomogram to Predict Response to Neoadjuvant Chemotherapy for Locally Advanced Cervical Cancer: A Two-Center Study
Yajiao Zhang, Chao Wu, Zhibo Xiao, Furong Lv, Yanbing Liu
Diagnostics.2023; 13(6): 1073. CrossRef
Machine Learning-Assisted Ensemble Analysis for the Prediction of Response to Neoadjuvant Chemotherapy in Locally Advanced Cervical Cancer
Yibao Huang, Qingqing Zhu, Liru Xue, Xiaoran Zhu, Yingying Chen, Mingfu Wu
Frontiers in Oncology.2022;[Epub] CrossRef

5,998 View
127 Download
5 Web of Science
4 Crossref

Gastrointestinal cancer

Evaluation and Comparison of Predictive Value of Tumor Regression Grades according to Mandard and Becker in Locally Advanced Gastric Adenocarcinoma: Yilin Tong, Yanmei Zhu, Yan Zhao, Zexing Shan, Dong Liu, Jianjun Zhang; Cancer Res Treat. 2021;53(1):112-122. Published online August 10, 2020; DOI: https://doi.org/10.4143/crt.2020.516

Abstract PDF Supplementary Material PubReader ePub

Purpose
Tumor regression grade (TRG) has been widely used in gastrointestinal carcinoma to assess pathological responses to neoadjuvant chemotherapy (NCT). There are various standards without a consensus, and it is still unclear which kind of system has better predictive value. This study aims to investigate and compare the predictive ability of the Mandard and Becker TRGs in patients with locally advanced gastric cancer.
Materials and Methods
A total of 290 patients with locally advanced gastric adenocarcinoma who underwent NCT and curative surgery were studied. Survival analysis for overall survival (OS) and disease-free survival (DFS) were based on the Kaplan-Meier method and Cox proportional hazards method. Predictive values of TRGs and models were assessed by time-dependent receiver operating characteristic (ROC) curve, the area under the ROC curve (AUC), nomogram, and calibration curve.
Results
In multivariable analysis, the Mandard TRG was associated with OS (hazard ratio [HR], 1.806; p=0.026) and DFS (HR, 1.792; p=0.017). The Becker TRG was also related to OS (HR, 1.880; p=0.014) and DFS (HR, 1.919; p=0.006). The Mandard and Becker TRG AUCs for 5-year survival were 0.72 and 0.71, respectively. The whole models showed an increased predictive value, with AUCs of 0.85 and 0.86, respectively. There was no significant difference between the two TRGs and two models.
Conclusion
TRG was an independent predictor for survival, and there was no significant difference between these two systems.

Citations

Citations to this article as recorded by

CT-Derived Quantitative Image Features Predict Neoadjuvant Treatment Response in Adenocarcinoma of the Gastroesophageal Junction with High Accuracy
Markus Graf, Sebastian Ziegelmayer, Stefan Reischl, Yannick Teumer, Florian T. Gassert, Alexander W. Marka, Philipp Raffler, Jeannine Bachmann, Marcus Makowski, Daniel Reim, Fabian Lohöfer, Egon Burian, Rickmer Braren
Cancers.2025; 17(2): 216. CrossRef
Microsatellite instability in gastric cancer: An institutional case series analysis in patients treated with neoadjuvant therapy
Laura Lorenzon, Alberto Biondi, Gloria Santoro, Annamaria Agnes, Antonio Laurino, Antonia Strippoli, Riccardo Ricci, Roberto Persiani, Domenico D'Ugo
Clinical Surgical Oncology.2024; 3(1): 100031. CrossRef
The Evolving Landscape of Neoadjuvant Immunotherapy in Gastroesophageal Cancer
Colum Dennehy, Alisha F. Khan, Ali H. Zaidi, Vincent K. Lam
Cancers.2024; 16(2): 286. CrossRef
Evaluating Treatment Response in GEJ Adenocarcinoma
Markus Graf, Joshua Gawlitza, Marcus Makowski, Felix Meurer, Thomas Huber, Sebastian Ziegelmayer
Investigative Radiology.2024; 59(8): 583. CrossRef
Deep learning nomogram for predicting neoadjuvant chemotherapy response in locally advanced gastric cancer patients
Jingjing Zhang, Qiang Zhang, Bo Zhao, Gaofeng Shi
Abdominal Radiology.2024; 49(11): 3780. CrossRef
Intratumoral heterogeneity affects tumor regression and Ki67 proliferation index in perioperatively treated gastric carcinoma
Magnus Kock am Brink, Laura Sophie Dunst, Hans-Michael Behrens, Sandra Krüger, Thomas Becker, Christoph Röcken
British Journal of Cancer.2023; 128(2): 375. CrossRef
Time to Surgery does not Affect Oncologic Outcomes in Locally Advanced Gastric Cancer after Neoadjuvant Chemotherapy: A Meta-Analysis
Zining Liu, Zhening Zhang, Hua Liu, Junbing Chen
Future Oncology.2023; 19(5): 397. CrossRef
Response Evaluation after Neoadjuvant Chemotherapy for Resectable Gastric Cancer
Alina Desiree Sandø, Reidun Fougner, Elin Synnøve Røyset, Hong Yan Dai, Jon Erik Grønbech, Erling Audun Bringeland
Cancers.2023; 15(8): 2318. CrossRef
Profiling complete regression after pre-operative therapy in gastric cancer patients using clinical and pathological data
Alberto Biondi, Laura Lorenzon, Gloria Santoro, Annamaria Agnes, Antonio Laurino, Roberto Persiani, Domenico D'Ugo
European Journal of Surgical Oncology.2023; 49(11): 106969. CrossRef
Concurrent clinical and pathological response predicts favorable prognosis of patients with gastric cancer after neoadjuvant therapy: a real-world study
Chongyuan Sun, Penghui Niu, Xiaojie Zhang, Lulu Zhao, Wanqing Wang, Xiaoyi Luan, Xue Han, Yingtai Chen, Dongbing Zhao
BMC Cancer.2023;[Epub] CrossRef
Sintilimab Plus Fluorouracil, Leucovorin, Oxaliplatin and Docetaxel Regimen as Neoadjuvant Therapy for Resectable Gastric Cancer and Biomarker Exploration
Jiangpeng Wei, Xin Guo, Xisheng Yang, Jinqiang Liu, Qianqian Duan, Yuan Tan, Qin Zhang, Tingting Sun, Chuang Qi, Xiaohua Li, Gang Ji
Future Oncology.2023; 19(36): 2395. CrossRef
Evaluation of dual-energy CT derived radiomics signatures in predicting outcomes in patients with advanced gastric cancer after neoadjuvant chemotherapy
Yong Chen, Fei Yuan, Lingyun Wang, Elsie Li, Zhihan Xu, Michael Wels, Weiwu Yao, Huan Zhang
European Journal of Surgical Oncology.2022; 48(2): 339. CrossRef
MORBIDITY AND SURVIVAL AFTER PERIOPERATIVE CHEMOTHERAPY IN GASTRIC CANCER: A STUDY USING THE BECKER’S CLASSIFICATION AND REGRESSION
Maria Cecília de Aguiar MACHADO, José Pedro Coimbra de Vargas Lobarinhas BARBOSA, Filipa Ferreira de OLIVEIRA, José Adelino Lobarinhas BARBOSA
ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo).2022;[Epub] CrossRef
Validating a nodal regression system for gastric cancer: An ancillary cohort study of the GASTRODOC trial
Luca Saragoni, Leonardo Solaini, Daniele Marrelli, Maria Raffaella Ambrosio, Maria Bencivenga, Anna Tomezzoli, Carlo Milandri, Valentina Terrinazzi, Gian Luca Baiocchi, Carla Baronchelli, Flavia Foca, Giorgio Ercolani, Paolo Morgagni
International Journal of Surgery.2021; 94: 106112. CrossRef
Comparison of tumor regression grading systems for locally advanced gastric adenocarcinoma after neoadjuvant chemotherapy
Zi-Ning Liu, Yin-Kui Wang, Li Zhang, Yong-Ning Jia, Shan Fei, Xiang-Ji Ying, Yan Zhang, Shuang-Xi Li, Yu Sun, Zi-Yu Li, Jia-Fu Ji
World Journal of Gastrointestinal Oncology.2021; 13(12): 2161. CrossRef

7,453 View
148 Download
17 Web of Science
15 Crossref

Survival Nomograms after Curative Neoadjuvant Chemotherapy and Radical Surgery for Stage IB2-IIIB Cervical Cancer: Claudia Marchetti, Francesca De Felice, Anna Di Pinto, Alessia Romito, Angela Musella, Innocenza Palaia, Marco Monti, Vincenzo Tombolin, Ludovico Muzii, PierLuigi Benedetti Panici; Cancer Res Treat. 2018;50(3):768-776. Published online July 19, 2017; DOI: https://doi.org/10.4143/crt.2017.141

Abstract PDF PubReader ePub

Purpose
The purpose of this study was to develop nomograms for predicting the probability of overall survival (OS) and progression-free survival (PFS) in locally advanced cervical cancer treated with neoadjuvant chemotherapy and radical surgery.
Materials and Methods
Nomograms to predict the 5-year OS rates and the 2-year PFS rates were constructed. Calibration plots were constructed, and concordance indices were calculated. Evaluated variableswere body mass index, age, tumor size, tumor histology, grading, lymphovascular space invasion, positive parametria, and positive lymph nodes.
Results
In total 245 patients with locally advanced cervical cancer who underwent neoadjuvant chemotherapy and radical surgery were included for the construction of the nomogram. The 5-year OS and PFS were 72.6% and 66%, respectively. Tumor size, grading, and parametria status affected the rate of OS, whereas tumor size and positive parametria were the main independent PFS prognostic factors.
Conclusion
We constructed a nomogram based on clinicopathological features in order to predict 2-year PFS and 5-year OS in locally advanced cervical cancer primarily treated with neoadjuvant chemotherapy followed by radical surgery. This tool might be particularly helpful for assisting in the follow-up of cervical cancer patients who have not undergone concurrent chemoradiotherapy.

Citations

Citations to this article as recorded by

Plasma-based proteomic and metabolomic characterization of lung and lymph node metastases in cervical cancer patients
Yue Feng, Zijian Sun, Huan Zhang, Zhao Wang, Lichao Wang, Hui Ye, Xiaojing Zhang, Zhuomin Yin, Juan Ni, Jingkui Tian, Hanmei Lou, Xiaojuan Lv, Wei Zhu
Journal of Pharmaceutical and Biomedical Analysis.2025; 253: 116521. CrossRef
Analysis of prognosis and related influencing factors of different surgical approaches for early cervical cancer
Lingling Ou, Lulu He, Qiaowen Bu, Hengying Wu, Bin Wen, Xiping Luo, Xiaoshan Hong
Journal of Cancer Research and Clinical Oncology.2025;[Epub] CrossRef
Dose prediction for cervical cancer in radiotherapy based on the beam channel generative adversarial network
Hui Xie, Tao Tan, Hua Zhang, Qing Li
Heliyon.2024; 10(18): e37472. CrossRef
Systematic review and meta-analysis of prediction models used in cervical cancer
Ashish Kumar Jha, Sneha Mithun, Umeshkumar B. Sherkhane, Vinay Jaiswar, Biche Osong, Nilendu Purandare, Sadhana Kannan, Kumar Prabhash, Sudeep Gupta, Ben Vanneste, Venkatesh Rangarajan, Andre Dekker, Leonard Wee
Artificial Intelligence in Medicine.2023; 139: 102549. CrossRef
Development and validation of radiomic signature for predicting overall survival in advanced-stage cervical cancer
Ashish Kumar Jha, Sneha Mithun, Umeshkumar B. Sherkhane, Vinay Jaiswar, Sneha Shah, Nilendu Purandare, Kumar Prabhash, Amita Maheshwari, Sudeep Gupta, Leonard Wee, V. Rangarajan, Andre Dekker
Frontiers in Nuclear Medicine.2023;[Epub] CrossRef
Advanced cervical stump cancer after laparoscopic subtotal hysterectomy: a case report of imaging, laparoscopic staging and treatment approach
Dimitrios Andrikos, Argyrios Andrikos, Antoine Naem, Olga Ebertz, Rajesh Devassy, Rudy Leon De Wilde, Michael Khamou, Harald Krentel
BMC Women's Health.2023;[Epub] CrossRef
Successful neoadjuvant chemotherapy plus sintilimab for locally advanced cervical cancer: case series and review of the literature
Linlin Liu, Xianbo Deng, Shuang Guo, Shouhua Yang
Diagnostic Pathology.2023;[Epub] CrossRef
Influence of the Clinical Nursing Pathway on Nursing Outcomes and Complications of Cervical Carcinoma Patients Undergoing Chemotherapy via PICC
Hongxia Tang, Li Gao, Yahui Li, Zhiqian Zhang
Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1. CrossRef
Current and future direction in treatment of HPV-related cervical disease
Niloofar Khairkhah, Azam Bolhassani, Reza Najafipour
Journal of Molecular Medicine.2022; 100(6): 829. CrossRef
Machine Learning of Dose-Volume Histogram Parameters Predicting Overall Survival in Patients with Cervical Cancer Treated with Definitive Radiotherapy
Zhiyuan Xu, Li Yang, Qin Liu, Hao Yu, Longhua Chen, Claudia Marchetti
Journal of Oncology.2022; 2022: 1. CrossRef
Efficacy and safety of pembrolizumab on cervical cancer: A systematic review and single-arm meta-analysis
Lin Qi, Ning Li, Aimin Lin, Xiuli Wang, Jianglin Cong
Frontiers in Oncology.2022;[Epub] CrossRef
Outcomes and prognostic factors in patients with locally advanced cervical cancer treated with concurrent chemoradiotherapy
Jing Liu, Guyu Tang, Qin Zhou, Weilu Kuang
Radiation Oncology.2022;[Epub] CrossRef
The comparative study for survival outcome of locally advanced cervical cancer treated by neoadjuvant arterial interventional chemotherapy or intravenous chemotherapy followed by surgery or concurrent chemoradiation
Yi Sun, Gailing Li, Panpan Hai, Yuan Cao, Pin Han, Yuchen Liu, Jing Wen, Yuanpei Wang, Xiaoran Cheng, Fang Ren
World Journal of Surgical Oncology.2022;[Epub] CrossRef
Pembrolizumab for advanced cervical cancer: safety and efficacy
Francesca De Felice, Elena Giudice, Giulia Bolomini, Maria Grazia Distefano, Giovanni Scambia, Anna Fagotti, Claudia Marchetti
Expert Review of Anticancer Therapy.2021; 21(2): 221. CrossRef
Nomograms predicting the overall survival and cancer-specific survival of patients with stage IIIC1 cervical cancer
Yifan Feng, Ye Wang, Yangqin Xie, Shuwei Wu, Yuyang Li, Min Li
BMC Cancer.2021;[Epub] CrossRef
Comparison of therapeutic effects of chemo-radiotherapy with neoadjuvant chemotherapy before radical surgery in patients with bulky cervical carcinoma (stage IB3 & IIA2)
Setareh Akhavan, Abbas Alibakhshi, Mahdieh Parsapoor, Abbas Alipour, Elahe Rezayof
BMC Cancer.2021;[Epub] CrossRef
Macleayins A From Macleaya Promotes Cell Apoptosis Through Wnt/β-Catenin Signaling Pathway and Inhibits Proliferation, Migration, and Invasion in Cervical Cancer HeLa Cells
Chunmei Sai, Wei Qin, Junyu Meng, Li-Na Gao, Lufen Huang, Zhen Zhang, Huannan Wang, Haixia Chen, Chaohua Yan
Frontiers in Pharmacology.2021;[Epub] CrossRef
Nomogram Predicting Overall Survival in Patients with FIGO II to III Squamous Cell Cervical Carcinoma Under Radical Radiotherapy: A Retrospective Analysis Based on 2018 FIGO Staging
Lele Zang, Qin Chen, Xiaozhen Zhang, Xiaohong Zhong, Jian Chen, Yi Fang, An Lin, Min Wang
Cancer Management and Research.2021; Volume 13: 9391. CrossRef
Prediction of early response to concurrent chemoradiotherapy in cervical cancer: Value of multi-parameter MRI combined with clinical prognostic factors
Xiaomin Zheng, Weiqian Guo, Jiangning Dong, Liting Qian
Magnetic Resonance Imaging.2020; 72: 159. CrossRef
Calculating the overall survival probability in patients with cervical cancer: a nomogram and decision curve analysis-based study
Guilan Xie, Ruiqi Wang, Li Shang, Cuifang Qi, Liren Yang, Liyan Huang, Wenfang Yang, Mei Chun Chung
BMC Cancer.2020;[Epub] CrossRef
SPP1 inhibition improves the cisplatin chemo-sensitivity of cervical cancer cell lines
Xing Chen, Dongsheng Xiong, Liya Ye, Huichun Yang, Shuangshuang Mei, Jinhong Wu, Shanshan Chen, Ruoran Mi
Cancer Chemotherapy and Pharmacology.2019; 83(4): 603. CrossRef
Systemic therapy in cervical cancer: 30 years in review
Michalis Liontos, Anastasios Kyriazoglou, Ioannis Dimitriadis, Meletios-Athanasios Dimopoulos, Aristotelis Bamias
Critical Reviews in Oncology/Hematology.2019; 137: 9. CrossRef
Adjuvant chemoradiotherapy versus radiotherapy in cervical cancer patients with intermediate-risk factors: A systematic review and meta-analysis
Meng Li, Mengyang Hu, Yuanjian Wang, Xingsheng Yang
European Journal of Obstetrics & Gynecology and Reproductive Biology.2019; 238: 1. CrossRef
Neoadjuvant chemotherapy followed by radical hysterectomy for stage IB2-to-IIB cervical cancer: a retrospective cohort study
Lei Li, Ming Wu, Shuiqing Ma, Xianjie Tan, Sen Zhong
International Journal of Clinical Oncology.2019; 24(11): 1440. CrossRef
Immune check-point in cervical cancer
F. De Felice, C. Marchetti, I. Palaia, R. Ostuni, L. Muzii, V. Tombolini, P. Benedetti Panici
Critical Reviews in Oncology/Hematology.2018; 129: 40. CrossRef

9,901 View
397 Download
31 Web of Science
25 Crossref

Locoregional Recurrence by Tumor Biology in Breast Cancer Patients after Preoperative Chemotherapy and Breast Conservation Treatment: Eunjin Jwa, Kyung Hwan Shin, Ja Young Kim, Young Hee Park, So-Youn Jung, Eun Sook Lee, In Hae Park, Keun Seok Lee, Jungsil Ro, Yeon-Joo Kim, Tae Hyun Kim; Cancer Res Treat. 2016;48(4):1363-1372. Published online February 18, 2016; DOI: https://doi.org/10.4143/crt.2015.456

Abstract PDF PubReader ePub

Purpose
The purpose of this study is to determine whether breast cancer subtype can affect locoregional recurrence (LRR) and ipsilateral breast tumor recurrence (IBTR) after neoadjuvant chemotherapy (NAC) and breast-conserving therapy (BCT). Materials and Methods We evaluated 335 consecutive patients with clinical stage II-III breast cancer who received NAC plus BCT from 2002 to 2009. Patients were classified according to six molecular subtypes: luminal A (hormone receptor [HR]+/HER2–/Ki-67 < 15%, n=113), luminal B1 (HR+/HER2–/Ki-67 ≥ 15%, n=33), luminal B2 (HR+/HER2+, n=83), HER2 with trastuzumab (HER2[T+]) (HR–/HER2+/use of trastuzumab, n=14), HER2 without trastuzumab (HER2[T–]) (HR–/HER2+, n=31), and triple negative (TN) (HR–/HER2–, n=61).
Results
After a median follow-up period of 7.2 years, 26 IBTRs and 37 LRRs occurred. The 5-year LRR-free survival rates were luminal A, 96.4%; B1, 93.9%; B2, 90.3%; HER2(T+), 92.9%; HER2(T–), 78.3%; and TN, 79.6%. The 5-year IBTR-free survival rates were luminal A, 97.2%; B1, 93.9%; B2, 92.8%; HER2(T+), 92.9%; HER2(T–), 89.1%; and TN, 84.6%. In multivariate analysis, HER2(T–) (IBTR: hazard ratio, 4.2; p=0.04 and LRR: hazard ratio, 7.6; p < 0.01) and TN subtypes (IBTR: hazard ratio, 6.9; p=0.01 and LRR: hazard ratio, 8.1; p < 0.01) were associated with higher IBTR and LRR rates. A pathologic complete response (pCR) was found to show correlation with better LRR and a tendency toward improved IBTR controls in TN patients (IBTR, p=0.07; LRR, p=0.03). Conclusion The TN and HER2(T–) subtypes predict higher rates of IBTR and LRR after NAC and BCT. A pCR is predictive of improved IBTR or LRR in TN subtype.

Citations

Citations to this article as recorded by

Prioritizing cases from a multi-institutional cohort for a dataset of pathologist annotations
Victor Garcia, Emma Gardecki, Stephanie Jou, Xiaoxian Li, Kenneth R. Shroyer, Joel Saltz, Balazs Acs, Katherine Elfer, Jochen Lennerz, Roberto Salgado, Brandon D. Gallas
Journal of Pathology Informatics.2025; 16: 100411. CrossRef
Mitomycin C in the treatment of early triple-negative locally advanced BRCA-associated breast cancer
D. A. Enaldieva, P. V. Krivorotko, E. N. Imyanitov, R. V. Donskih, A. P. Sokolenko, V. O. Azaova, N. N. Amirov, Ya. Ig. Bondarchuk, V. E. Levcheko, D. G. Ulrikh, V. F. Semiglazov
Medical alphabet.2024; (7): 13. CrossRef
Tissue- and Temporal-Dependent Dynamics of Myeloablation in Response to Gemcitabine Chemotherapy
Lydia E. Kitelinger, Eric A. Thim, Sarah Y. Zipkowitz, Richard J. Price, Timothy N. J. Bullock
Cells.2024; 13(16): 1317. CrossRef
Risk of locoregional recurrence after breast cancer surgery by molecular subtype—a systematic review and network meta-analysis
Lily Nolan, Matthew G. Davey, Gavin G. Calpin, Éanna J. Ryan, Michael R. Boland
Irish Journal of Medical Science (1971 -).2024; 193(6): 2965. CrossRef
Local-Regional Recurrence After Neoadjuvant Endocrine Therapy: Data from ACOSOG Z1031 (Alliance), a Randomized Phase 2 Neoadjuvant Comparison Between Letrozole, Anastrozole, and Exemestane for Postmenopausal Women with Estrogen Receptor-Positive Clinical
Kelly K. Hunt, Vera J. Suman, Hannah F. Wingate, A. Marilyn Leitch, Gary Unzeitig, Judy C. Boughey, Funda Meric-Bernstam, Matthew J. Ellis, John Olson
Annals of Surgical Oncology.2023; 30(4): 2111. CrossRef
Margin Width and Local Recurrence in Patients Undergoing Breast Conservation After Neoadjuvant Chemotherapy
Mary Mrdutt, Alexandra Heerdt, Varadan Sevilimedu, Anita Mamtani, Andrea Barrio, Monica Morrow
Annals of Surgical Oncology.2022; 29(1): 484. CrossRef
Three-year follow-up of de-escalated axillary treatment after neoadjuvant systemic therapy in clinically node-positive breast cancer: the MARI-protocol
Ariane A. van Loevezijn, Marieke E. M. van der Noordaa, Marcel P. M. Stokkel, Erik D. van Werkhoven, Emma J. Groen, Claudette E. Loo, Paula H. M. Elkhuizen, Gabe S. Sonke, Nicola S. Russell, Frederieke H. van Duijnhoven, Marie-Jeanne T. F. D. Vrancken Pee
Breast Cancer Research and Treatment.2022; 193(1): 37. CrossRef
De-escalation of radiotherapy after primary chemotherapy in cT1–2N1 breast cancer (RAPCHEM; BOOG 2010–03): 5-year follow-up results of a Dutch, prospective, registry study
Sabine R de Wild, Linda de Munck, Janine M Simons, Janneke Verloop, Thijs van Dalen, Paula H M Elkhuizen, Ruud M A Houben, A Elise van Leeuwen, Sabine C Linn, Ruud M Pijnappel, Philip M P Poortmans, Luc J A Strobbe, Jelle Wesseling, Adri C Voogd, Liesbeth
The Lancet Oncology.2022; 23(9): 1201. CrossRef
Triple-negative breast cancer: current treatment strategies and factors of negative prognosis
Anna Baranova, Mykola Krasnoselskyi, Volodymyr Starikov, Sergii Kartashov, Igor Zhulkevych, Vadym Vlasenko, Kateryna Oleshko, Olga Bilodid, Marina Sadchikova, Yurii Vinnyk
Journal of Medicine and Life.2022; 15(2): 153. CrossRef
Risk Factors for Ipsilateral Breast Tumor Recurrence in Triple-Negative or HER2-Positive Breast Cancer Patients Who Achieve a Pathologic Complete Response After Neoadjuvant Chemotherapy
Makoto Ishitobi, Naoko Matsuda, Mizuho Tazo, Sayuka Nakayama, Ryu Tokui, Tomoko Ogawa, Atsushi Yoshida, Yasuyuki Kojima, Takashi Kuwayama, Takahiro Nakayama, Hideko Yamauchi, Seigo Nakamura, Koichiro Tsugawa, Naoki Hayashi
Annals of Surgical Oncology.2021; 28(5): 2545. CrossRef
Disease-free and overall survival after neoadjuvant chemotherapy in breast cancer: breast-conserving surgery compared to mastectomy in a large single-centre cohort study
Janine M. Simons, Julien G. Jacobs, Joost P. Roijers, Maarten A. Beek, Leandra J. M. Boonman-de Winter, Arjen M. Rijken, Paul D. Gobardhan, Jan H. Wijsman, Eric Tetteroo, Joan B. Heijns, C. Y. Yick, Ernest J. T. Luiten
Breast Cancer Research and Treatment.2021; 185(2): 441. CrossRef
Evaluating the effect of neoadjuvant chemotherapy on surgical outcomes after breast conserving surgery
Matthew R. Woeste, Neal Bhutiani, Marilyn Donaldson, Kelly M. McMasters, Nicolás Ajkay
Journal of Surgical Oncology.2021; 123(2): 439. CrossRef
Does Surgical Margin Width Remain a Challenge for Triple-Negative Breast Cancer? A Retrospective Analysis
Eduard-Alexandru Bonci, Ștefan Țîțu, Alexandru Marius Petrușan, Claudiu Hossu, Vlad Alexandru Gâta, Morvarid Talaeian Ghomi, Paul Milan Kubelac, Teodora Irina Bonci, Andra Piciu, Maria Cosnarovici, Liviu Hîțu, Alexandra Timea Kirsch-Mangu, Diana Cristina
Medicina.2021; 57(3): 203. CrossRef
Factors affecting locoregional recurrence in breast cancer patients undergoing surgery following neoadjuvant treatment
Hsu-Huan Chou, Wei-Shan Chung, Rong-Yao Ding, Wen-Ling Kuo, Chi-Chang Yu, Hsiu-Pei Tsai, Shih-Che Shen, Chia-Hui Chu, Yung-Feng Lo, Shin-Cheh Chen
BMC Surgery.2021;[Epub] CrossRef
Correlation between outcome and extent of residual disease in the sentinel node after neoadjuvant chemotherapy in clinically fine-needle proven node-positive breast cancer patients
Giuseppe Canavese, Corrado Tinterri, Franca Carli, Elsa Garrone, Stefano Spinaci, Angelica Della Valle, Erika Barbieri, Emilia Marrazzo, Paolo Bruzzi, Beatrice Dozin
European Journal of Surgical Oncology.2021; 47(8): 1920. CrossRef
Diverse Distribution and Gene Expression on the 21-Gene Recurrence Assay in Breast Cancer Patients with Locoregional Recurrence Versus Distant Metastasis
Yujie Lu, Yiwei Tong, Jiahui Huang, Lin Lin, Jiayi Wu, Xiaochun Fei, Xiaosong Chen, Kunwei Shen
Cancer Management and Research.2021; Volume 13: 6279. CrossRef
De-escalation of axillary irradiation for early breast cancer – Has the time come?
Elżbieta Senkus, Maria Joao Cardoso, Orit Kaidar-Person, Aleksandra Łacko, Icro Meattini, Philip Poortmans
Cancer Treatment Reviews.2021; 101: 102297. CrossRef
Impact of Surgical Margins in Breast Cancer After Preoperative Systemic Chemotherapy on Local Recurrence and Survival
K. Wimmer, M. Bolliger, Z. Bago-Horvath, G. Steger, D. Kauer-Dorner, R. Helfgott, C. Gruber, F. Moinfar, M. Mittlböck, F. Fitzal
Annals of Surgical Oncology.2020; 27(5): 1700. CrossRef
Association of surgical margins with local recurrence in patients undergoing breast-conserving surgery after neoadjuvant chemotherapy
Joseph Lin, Kuo-Juei Lin, Yu-Fen Wang, Ling-Hui Huang, Sam Li-Sheng Chen, Dar-Ren Chen
BMC Cancer.2020;[Epub] CrossRef
Identifying Risk Factors for Regional Recurrence in Early-Stage Breast Cancer with pT1-2 and Negative Sentinel Lymph Node Biopsy

Kai-yun You, Zhuo-fei Bi, Lin Ding, Yu-jia Ma, Yi-min Liu, He-rui Yao
Cancer Management and Research.2020; Volume 12: 9211. CrossRef
Discordance between Primary Breast Cancer and Ipsilateral Breast Cancer Tumor Recurrence as a Function of Distance
Sebastian M. Jud, Reinhard Hatko, Julius Emons, Bianca Lauterbach, Carolin C. Hack, Caroline Preuß, Werner Adler, Matthias W. Beckmann, Felix Heindl
Journal of Clinical Medicine.2020; 9(12): 4033. CrossRef
A common Chk1-dependent phenotype of DNA double-strand break suppression in two distinct radioresistant cancer types
Patrick H. Dinkelborg, Meng Wang, Liliana Gheorghiu, Joseph M. Gurski, Theodore S. Hong, Cyril H. Benes, Dejan Juric, Rachel B. Jimenez, Kerstin Borgmann, Henning Willers
Breast Cancer Research and Treatment.2019; 174(3): 605. CrossRef
The reciprocal influences of prognosis between two types of surgical interventions and early breast cancer patients with diverse luminal subtypes
Lin He, Shengnan Zhao, Min Liu, Zhumin Su, Yuanzhong Ren, Yuhua Song
Medicine.2019; 98(11): e14912. CrossRef
Integrative In Vivo Drug Testing Using Gene Expression Signature and Patient-Derived Xenografts from Treatment-Refractory HER2 Positive and Triple-Negative Subtypes of Breast Cancer
Jin-Sun Ryu, Sung Hoon Sim, In Hae Park, Eun Gyeong Lee, Eun Sook Lee, Yun-Hee Kim, Youngmee Kwon, Sun-Young Kong, Keun Seok Lee
Cancers.2019; 11(4): 574. CrossRef
Partial-Breast Irradiation: Review of Modern Trials
Bindu Manyam, Chirag Shah, Thomas Julian, Frank Vicini
Current Breast Cancer Reports.2019; 11(4): 277. CrossRef
AGO Recommendations for the Diagnosis and Treatment of Patients with Locally Advanced and Metastatic Breast Cancer: Update 2019
Marc Thill, Christian Jackisch, Wolfgang Janni, Volkmar Müller, Ute-Susann Albert, Ingo Bauerfeind, Jens Blohmer, Wilfried Budach, Peter Dall, Ingo Diel, Peter A. Fasching, Tanja Fehm, Michael Friedrich, Bernd Gerber, Volker Hanf, Nadia Harbeck, Jens Huob
Breast Care.2019; 14(4): 247. CrossRef
The American Brachytherapy Society consensus statement for accelerated partial-breast irradiation
Chirag Shah, Frank Vicini, Simona F. Shaitelman, Jaroslaw Hepel, Martin Keisch, Douglas Arthur, Atif J. Khan, Robert Kuske, Rakesh Patel, David E. Wazer
Brachytherapy.2018; 17(1): 154. CrossRef
Breast Cancer Biology: Clinical Implications for Breast Radiation Therapy
Janet K. Horton, Reshma Jagsi, Wendy A. Woodward, Alice Ho
International Journal of Radiation Oncology*Biology*Physics.2018; 100(1): 23. CrossRef
Risk factors for locoregional disease recurrence after breast‐conserving therapy in patients with breast cancer treated with neoadjuvant chemotherapy: An international collaboration and individual patient meta‐analysis
Antonios Valachis, Eleftherios P. Mamounas, Elizabeth A. Mittendorf, Naoki Hayashi, Makoto Ishitobi, Clara Natoli, Florian Fitzal, Isabel T. Rubio, Daniel G. Tiezzi, Hee‐Chul Shin, Stewart J. Anderson, Kelly K. Hunt, Naoko Matsuda, Shozo Ohsumi, Athina To
Cancer.2018; 124(14): 2923. CrossRef
Margins in Breast-Conserving Surgery After Neoadjuvant Therapy
Jungeun Choi, Alison Laws, Jiani Hu, William Barry, Mehra Golshan, Tari King
Annals of Surgical Oncology.2018; 25(12): 3541. CrossRef
Critical review of axillary recurrence in early breast cancer
Carlos A. Castaneda, Pamela Rebaza, Miluska Castillo, Henry L. Gomez, Miguel De La Cruz, Gabriela Calderon, Jorge Dunstan, Jose Manuel Cotrina, Julio Abugattas, Tatiana Vidaurre
Critical Reviews in Oncology/Hematology.2018; 129: 146. CrossRef
Effects of trastuzumab on locoregional recurrence in human epidermal growth factor receptor 2-overexpressing breast cancer patients treated with chemotherapy and radiotherapy
Seung Hyuck Jeon, Kyung Hwan Shin, Jin Ho Kim, Kyubo Kim, In Ah Kim, Kyung-Hun Lee, Tae-Yong Kim, Seock-Ah Im
Breast Cancer Research and Treatment.2018; 172(3): 619. CrossRef
Pathologic response after neoadjuvant chemotherapy predicts locoregional control in patients with triple negative breast cancer
Victor E. Chen, Erin F. Gillespie, Kaveh Zakeri, James D. Murphy, Catheryn M. Yashar, Sharon Lu, John P. Einck
Advances in Radiation Oncology.2017; 2(2): 105. CrossRef
Factors predictive of locoregional recurrence following neoadjuvant chemotherapy in patients with large operable or locally advanced breast cancer: An analysis of the EORTC 10994/BIG 1-00 study
Pauline Gillon, Nathan Touati, Christel Breton-Callu, Leen Slaets, David Cameron, Hervé Bonnefoi
European Journal of Cancer.2017; 79: 226. CrossRef
Age, molecular subtypes and local therapy decision-making
Anne Kuijer, Tari A. King
The Breast.2017; 34: S70. CrossRef
Identification of glycerol-3-phosphate dehydrogenase 1 as a tumour suppressor in human breast cancer
Cefan Zhou, Jing Yu, Ming Wang, Jing Yang, Hui Xiong, Huang Huang, Dongli Wu, Shimeng Hu, Yefu Wang, Xing-Zhen Chen, Jingfeng Tang
Oncotarget.2017; 8(60): 101309. CrossRef
Prognostic significance of PLIN1 expression in human breast cancer
Cefan Zhou, Ming Wang, Li Zhou, Yi Zhang, Weiyong Liu, Wenying Qin, Rong He, Yang Lu, Yefu Wang, Xing-Zhen Chen, Jingfeng Tang
Oncotarget.2016; 7(34): 54488. CrossRef

15,727 View
359 Download
38 Web of Science
37 Crossref

Breast Cancer–Related Lymphedema after Neoadjuvant Chemotherapy: Myungsoo Kim, In Hae Park, Keun Seok Lee, Jungsil Ro, So-Youn Jung, Seeyoun Lee, Han-Sung Kang, Eun Sook Lee, Tae Hyun Kim, Kwan Ho Cho, Kyung Hwan Shin; Cancer Res Treat. 2015;47(3):416-423. Published online November 17, 2014; DOI: https://doi.org/10.4143/crt.2014.079

Abstract PDF PubReader ePub

Purpose
The risk for lymphedema (LE) after neoadjuvant chemotherapy (NCT) in breast cancer patients has not been fully understood thus far. This study is conducted to investigate the incidence and time course of LE after NCT. Materials and Methods A total of 313 patients with clinically node-positive breast cancer who underwent NCT followed by surgery with axillary lymph node (ALN) dissection from 2004 to 2009 were retrospectively analyzed. All patients received breast and supraclavicular radiation therapy (SCRT). The determination of LE was based on both objective and subjective methods, as part of a prospective database. Results At a median follow-up of 5.6 years, 132 patients had developed LE: 88 (28%) were grade 1; 42 (13%) were grade 2; and two (1%) were grade 3. The overall 5-year cumulative incidence of LE was 42%. LE first occurred within 6 months after surgery in 62%; 1 year in 77%; 2 years in 91%; and 3 years in 96%. In a multivariate analysis, age (hazard ratio [HR], 1.66; p < 0.01) and the number of dissected ALNs (HR, 1.68; p < 0.01) were independent risk factors for LE. Patients with both of these risk factors showed a significantly higher 5-year cumulative incidence of LE compared with patients with no or one risk factor (61% and 37%, respectively; p < 0.001). The addition of adjuvant chemotherapy did not significantly correlate with LE. Conclusion LE after NCT, surgery, and SCRT developed early after treatment, and with a high incidence rate. More frequent surveillance of arm swelling may be necessary in patients after NCT, especially during the first few years of follow-up.

Citations

Citations to this article as recorded by

Association between chemotherapy and the risk of developing breast cancer-related lymphedema: a nationwide retrospective cohort study
Sung Hoon Jeong, Seong Min Chun, Hyunji Lee, Miji Kim, Mira Choi, Ja-Ho Leigh
Supportive Care in Cancer.2025;[Epub] CrossRef
Protective Factors Associated with Normal Lymphatic Function After Axillary Lymph Node Dissection for Breast Cancer Treatment
Janet C. Coleman-Belin, Jonathan Rubin, Lillian A. Boe, Richard Diwan, Jasmine J. L. Monge, Dinh-Do Dinh, Emily Bloomfield, Babak Mehrara, Michelle Coriddi
Annals of Surgical Oncology.2025;[Epub] CrossRef
Multimodal treatments and the risk of breast cancer-related lymphedema: insights from a nationally representative cohort in South Korea
Sung Hoon Jeong, Seong Min Chun, Miji Kim, Ye Seol Lee, Jisun Kim, Ja-Ho Leigh, Yoon-Hee Choi
BMC Cancer.2025;[Epub] CrossRef
Exercise‐Induced Cardiac Lymphatic Remodeling Mitigates Inflammation in the Aging Heart
Kangsan Roh, Haobo Li, Rebecca Nicole Freeman, Luca Zazzeron, Ahlim Lee, Charles Zhou, Siman Shen, Peng Xia, Justin Ralph Baldovino Guerra, Cedric Sheffield, Timothy P. Padera, Yirong Zhou, Sekeun Kim, Aaron Aguirre, Nicolas Houstis, Jason D. Roh, Fumito
Aging Cell.2025;[Epub] CrossRef
Impact of neoadjuvant chemotherapy on breast cancer-related lymphedema after axillary lymph node dissection: a retrospective cohort study
Miaomiao Jia, Lihui Pan, Haibo Yang, Jinnan Gao, Fan Guo
Breast Cancer Research and Treatment.2024; 204(2): 223. CrossRef
Incidence and risk factors of breast cancer-related lymphedema in Korea: a nationwide retrospective cohort study
Ha Rim Ahn, Hyeong Eun Jeong, Choyun Jeong, Sang Yull Kang, Sung Hoo Jung, Hyun Jo Youn, Jong Seung Kim
International Journal of Surgery.2024; 110(6): 3518. CrossRef
Incidence of lymphedema related to various cancers
Marie-Eve Letellier, Marize Ibrahim, Anna Towers, Geneviève Chaput
Medical Oncology.2024;[Epub] CrossRef
Age as a risk factor for breast cancer-related lymphedema: a systematic review
Gunel Guliyeva, Maria T. Huayllani, Daniel Boczar, Francisco R. Avila, Xiaona Lu, Antonio Jorge Forte
Journal of Cancer Survivorship.2023; 17(1): 246. CrossRef
Risk factors of unilateral breast cancer-related lymphedema: an updated systematic review and meta-analysis of 84 cohort studies
Aomei Shen, Qian Lu, Xin Fu, Xiaoxia Wei, Liyuan Zhang, Jingru Bian, Wanmin Qiang, Dong Pang
Supportive Care in Cancer.2023;[Epub] CrossRef
Beyond cardiomyocytes: Cellular diversity in the heart's response to exercise
Lena E. Trager, Margaret Lyons, Alexandra Kuznetsov, Cedric Sheffield, Kangsan Roh, Rebecca Freeman, James Rhee, J. Sawalla Guseh, Haobo Li, Anthony Rosenzweig
Journal of Sport and Health Science.2023; 12(4): 423. CrossRef
Managing the Morbidity
Giacomo Montagna, Andrea V. Barrio
Surgical Oncology Clinics of North America.2023; 32(4): 705. CrossRef
Risk of Lymphedema and Death after Lymph Node Dissection with Neoadjuvant and Adjuvant Treatments in Patients with Breast Cancer: An Eight-Year Nationwide Cohort Study
Ye-Seul Lee, Yu-Cheol Lim, Jiyoon Yeo, Song-Yi Kim, Yoon Jae Lee, In-Hyuk Ha
Healthcare.2023; 11(13): 1833. CrossRef
Discussion: Variable Anatomy of the Lateral Upper Arm Lymphatic Channel: An Anatomical Risk Factor for Breast Cancer–Related Lymphedema
Mengfan Wu, Shailesh Agarwal
Plastic & Reconstructive Surgery.2023; 152(2): 430. CrossRef
Breast cancer treatment‐related arm lymphoedema and morbidity: A 6‐year experience in an Australian tertiary breast centre
Yang Yang Huang, Pei Yinn Toh, Catherine Hunt, Joshua Tzi Wei Lin, Roshi Kamyab, Ananda Kallyani Ponniah
Asia-Pacific Journal of Clinical Oncology.2022; 18(1): 109. CrossRef
Cancer Rehabilitation Fact Sheet in Korea
Jin A Yoon, Bo Young Hong
Annals of Rehabilitation Medicine.2022; 46(4): 155. CrossRef
Burden of lymphedema in long‐term breast cancer survivors by race and age
Yumeng Ren, Michael A. Kebede, Adeyemi A. Ogunleye, Marc A. Emerson, Kelly R. Evenson, Lisa A. Carey, Sandra C. Hayes, Melissa A. Troester
Cancer.2022; 128(23): 4119. CrossRef
Acquired lymphedema: Molecular contributors and future directions for developing intervention strategies
Ika Nurlaila, Kangsan Roh, Chang-Hwan Yeom, Hee Kang, Sukchan Lee
Frontiers in Pharmacology.2022;[Epub] CrossRef
Prediction of breast cancer-related lymphedema risk after postoperative radiotherapy via multivariable logistic regression analysis
Jae Sik Kim, Jin Ho Kim, Ji Hyun Chang, Do Wook Kim, Kyung Hwan Shin
Frontiers in Oncology.2022;[Epub] CrossRef
Histological features of skin and subcutaneous tissue in patients with breast cancer who have received neoadjuvant chemotherapy and their relationship to post-treatment edema
Ayako Nakagawa, Hiroshi Fujimoto, Takeshi Nagashima, Takafumi Sangai, Mamoru Takada, Takahito Masuda, Ryotaro Teranaka, Satoshi Ota, Jun Matsushima, Shinsuke Akita, Masayuki Ohtsuka
Breast Cancer.2020; 27(1): 77. CrossRef
A scoring system for predicting the risk of breast cancer-related lymphedema
Fenglian Li, Qian Lu, Sanli Jin, Quanping Zhao, Xueying Qin, Shuai Jin, Lichuan Zhang
International Journal of Nursing Sciences.2020; 7(1): 21. CrossRef
Body Mass Index as a Major Risk Factor for Severe Breast Cancer-Related Lymphedema
Hélène Leray, Julie Malloizel-Delaunay, Amélie Lusque, Elodie Chantalat, Léonard Bouglon, Charlotte Chollet, Benoit Chaput, Barbara Garmy-Susini, Alexandra Yannoutsos, Charlotte Vaysse
Lymphatic Research and Biology.2020; 18(6): 510. CrossRef
Factors Associated With Lymphedema in Women With Node-Positive Breast Cancer Treated With Neoadjuvant Chemotherapy and Axillary Dissection
Jane M. Armer, Karla V. Ballman, Linda McCall, Pamela L. Ostby, Eris Zagar, Henry M. Kuerer, Kelly K. Hunt, Judy C. Boughey
JAMA Surgery.2019; 154(9): 800. CrossRef
Breast deformation during the course of radiotherapy: The need for an additional outer margin
J. Seppälä, K. Vuolukka, T. Virén, J. Heikkilä, J.T.J. Honkanen, A. Pandey, A. Al-Gburi, M. Shah, S. Sefa, T. Koivumäki
Physica Medica.2019; 65: 1. CrossRef
Current and future perspectives on the evaluation, prevention and conservative management of breast cancer related lymphoedema: A best practice guideline
Nick Gebruers, Hanne Verbelen, Tessa De Vrieze, Lore Vos, Nele Devoogdt, Lore Fias, Wiebren Tjalma
European Journal of Obstetrics & Gynecology and Reproductive Biology.2017; 216: 245. CrossRef
Incidence and risk factors of lymphedema after breast cancer treatment: 10 years of follow-up
Ana Carolina Padula Ribeiro Pereira, Rosalina Jorge Koifman, Anke Bergmann
The Breast.2017; 36: 67. CrossRef
Risk factors for lymphoedema in women with breast cancer: A large prospective cohort
S.L. Kilbreath, K.M. Refshauge, J.M. Beith, L.C. Ward, O.A. Ung, E.S. Dylke, J.R. French, J. Yee, L. Koelmeyer, K. Gaitatzis
The Breast.2016; 28: 29. CrossRef
Identification of Prognostic Risk Factors for Transient and Persistent Lymphedema after Multimodal Treatment for Breast Cancer
Myungsoo Kim, Kyung Hwan Shin, So-Youn Jung, Seeyoun Lee, Han-Sung Kang, Eun Sook Lee, Seung Hyun Chung, Yeon-Joo Kim, Tae Hyun Kim, Kwan Ho Cho
Cancer Research and Treatment.2016; 48(4): 1330. CrossRef
Local Treatment of Breast Cancer
Joanne Lester
Seminars in Oncology Nursing.2015;[Epub] CrossRef
Discrepant Trajectories of Impairment, Activity, and Participation Related to Upper-Limb Function in Patients With Breast Cancer
Eun Joo Yang, Eunyoung Kang, Sung-Won Kim, Jae-Young Lim
Archives of Physical Medicine and Rehabilitation.2015; 96(12): 2161. CrossRef

15,086 View
121 Download
31 Web of Science
29 Crossref

Case Report

A Locally Advanced Breast Cancer with Difficult Differential Diagnosis of Carcinosarcoma and Atypical Medullary Carcinoma, which had Poor Response to Adriamycin- and Taxane-based Neoadjuvant Chemotherapy: A Case Report: Se Hyun Kim, Hyun Cheol Chung, Jaeheon Jeong, Ji Hoon Kim, Sun Young Rha, Joong Bae Ahn, Nam Hoon Cho, Hei-Cheul Jeung; Cancer Res Treat. 2007;39(3):134-137. Published online September 30, 2007; DOI: https://doi.org/10.4143/crt.2007.39.3.134

Abstract PDF PubReader ePub

Atypical medullary carcinomas and carcinosarcoma have unique histopathological features. Here we present a case with a breast malignancy that had pathological characteristics of both. A 54-year old patient with a malignant breast mass received 6 cycles of adriamycin-based chemotherapy, followed by 3 cycles of paclitaxel monotherapy, and had a poor clinical response to treatment. A modified radical mastectomy was performed. The pathological diagnosis was complicated by an inability to distinguish between atypical medullary carcinoma and carcinosarcoma. The findings included a tumor that was well-circumscribed, high grade and a syncytial growth pattern as well as biphasic sarcomatous and carcinomatous characteristics. In conclusion, atypical medullary carcinoma and carcinosarcoma of the breast have entirely different prognoses and should be managed differently. Both should be treated by surgical resection, and additional therapy should be considered based on the cancer with the poorer prognosis.

Citations

Citations to this article as recorded by

Carcinosarcoma of the breast: Facing the challenge of a rare nosologic entity
Aikaterini Mastoraki, Maria Tsamopoulou, Foivos-Konstantinos Stamatis, Alexios Strimpakos, Ero Mouchtouri, Christiana Panagi, Evgenia Mela, Sotiria Mastoraki, Aristotelis Kechagias, Dimitrios Schizas
World Journal of Clinical Cases.2025;[Epub] CrossRef
A Rare Case of Primary Carcinosarcoma of the Breast
Maria Kiakou, Maria Tolia, Nektarios Koufopoulos, Konstantinos Tsapakidis, Eleni Arvanitou, Gkikas Konstantinos, Nikolaos Charalambakis, Michalis Nikolaou, Dimitrios Matthaios, Nikolaos Tsoukalas
Forum of Clinical Oncology.2022; 13(1): 48. CrossRef
Carcinosarcoma (Metaplastic Carcinoma) Breast: A Rare and Aggressive Primary – Report of Two Cases with Review of Literature
Gunjesh Kumar Singh, Pragya Singh, KT Bhowmik
Indian Journal of Medical and Paediatric Oncology.2018; 39(03): 400. CrossRef
Carcinosarcoma of the Breast: An Aggressive Subtype of Metaplastic Cancer. Report of a Rare Case in a Young BRCA-1 Mutated Woman
Matteo Ghilli, Donatella M. Mariniello, Giovanni Fanelli, Francesca Cascione, Andrea Fontana, Agostino Cristaudo, Anna Cilotti, Adelaide M. Caligo, Giampiero Manca, Livio Colizzi, Antonio G. Naccarato, Manuela Roncella
Clinical Breast Cancer.2017; 17(1): e31. CrossRef

9,716 View
70 Download
4 Crossref

Review Articles

Recent Advances in Management of Laryngeal Cancer: Youn Sang Shim; Cancer Res Treat. 2004;36(1):13-18. Published online February 29, 2004; DOI: https://doi.org/10.4143/crt.2004.36.1.13

Abstract PDF PubReader ePub

Laryngeal cancers account for approximately 1.5% (1~2%) of the total cancers in Korea, and 30% of all head and neck cancers, not including thyroid cancer. Early laryngeal cancer is treated by operation, including transoral laser excision or radiotherapy. Advanced laryngeal cancer has been treated with mutilating operations, such as a total laryngectomy. However, a laryngeal preserving approach, which can improve the quality of life, has recently been tried with advanced laryngeal cancer.

Citations

Citations to this article as recorded by

Flavonoids inhibitory effect and mechanism on laryngeal carcinoma cell cytotoxicity in AGEs/RAGE/NF-κB pathway
Zhigang Bai, Dongli Zhang, Enhong Shi
Materials Express.2023; 13(4): 591. CrossRef
Laser treatment for larynx cancer: an overview of techniques and complications
Seung Hoon Woo
Medical Lasers.2023; 12(2): 84. CrossRef
Comparative assessment of HPV, alcohol and tobacco etiological fractions in Algerian patients with laryngeal squamous cell carcinoma
Nora Kariche, Montserrat Torres Hortal, Samir Benyahia, Laia Alemany, Nabila Moulaï, Omar Clavero, Marleny Muñoz, Wahiba Ouahioune, Djamel Djennaoui, Chafia Touil-Boukoffa, Silvia de Sanjosé, Mehdi Bourouba
Infectious Agents and Cancer.2018;[Epub] CrossRef
Squamous Cell Carcinoma of Supraglottic
S.P. Indra Kumar, Gayathri Priyadharshini LNU, Priyadharshini LNU, Venkat Narayanan
Journal of Scientific Dentistry.2016; 6(1): 20. CrossRef

9,073 View
54 Download
4 Crossref

Combined Modality Therapy for Locally Advanced Non-Small Cell Lung Cancer: L Chinsoo Cho, J Michael Dimaio, Randall Hughes, Phuc Nguyen, Paula Anderson, Hak Choy; Cancer Res Treat. 2003;35(5):373-382. Published online October 31, 2003; DOI: https://doi.org/10.4143/crt.2003.35.5.373

Abstract PDF: The majority of non-small cell lung cancer patients present with locally advanced disease that may not be resectable. A single modality treatment such as thoracic radiotherapy often results in an inferior outcome when compared to combined modality treatment. Various combinations of radiotherapy, chemotherapy, and surgery have been tested in patients with locally advanced non-small-celllung cancer with promising results. The favorable results of the combined modality treatment are accompanied by a corresponding increase in treatment related morbidity. In this article, the results of the application of combined modality treatments in the management of locally advanced non-small cell lung cancer are reviewed.

3,557 View
27 Download

Original Articles

Impact of Neoadjuvant Chemotherapy on Postoperative Morbidity in Locally Advanced Cervical Carcinoma: Tae Sung Lee, Mi Suk Kim, Suk Bong Koh, Youn Seok Choi; Cancer Res Treat. 2002;34(3):186-190. Published online June 30, 2002; DOI: https://doi.org/10.4143/crt.2002.34.3.186

Abstract PDF

PURPOSE
The purpose of this study was to test the hypothesis that neoadjuvant chemotherapy (NACT) does not increase morbidity in patients undergoing radical hysterectomy with lymphadenectomy for locally advanced cervical cancer. MATERIALS AND METGODS: A retrospective study was undertaken of 140 patients with locally advanced cervical cancer (FIGO stage Ia to IIb) who underwent radical hysterectomy with lymphadenectomy by the same surgeon at the same hospital. Among the 140 patients, 39 received NACT followed by radical hysterectomy with pelvic lymphadenectomy (NACT group). This group received three cycles consisting of cisplatin 100 mg/m2/day on day 1 and 5-fluorouracil 1000 mg/m2/day from day 1 to 5. The NACT group was compared, in terms of intraoperative morbidity and postoperative morbidity, with the other 101 patients who underwent radical hysterectomy with lymphadenectomy but without chemotherapy (surgery-only group).
RESULTS
There were no significant differences in mean age, body weight or height between the two groups. The only significant difference was that the NACT patients had higher stages of cancer. The incidence of intraoperative morbidity did not differ between the NACT and surgery only patients. We considered the operation duration, amount of blood loss and need for transfusion as indicators of intraoperative morbidity. We could not find any significant differences in the duration of suprapubic catheterization, days of hemovac drainage, amount of drained hemovac fluid, days of hospitalization or postoperative febrile morbidity between the NACT and surgery-only groups. Patients in the surgery-only group had more postoperative complications (ureteral obstruction, intestinal obstruction, lymphocyst, lymphedema, and death) than the NACT group, although not to a statistically significant degree (P>0.05).
CONCLUSION
In this retrospective review, there was no evidence that NACT increased intraoperative or postoperative morbidity in patients with locally advanced cervical cancer. As this was a retrospective study, other prospective, randomized studies are needed to confirm these results.

Citations

Citations to this article as recorded by

Role of Pelvic Ultrasound in Predicting the Response to Neoadjuvant Chemotherapy in Locally Advanced Cervical Cancer
Giorgia Perniola, Giulia Paoni Saccone, Noemi Tonti, Federica Tanzi, Innocenza Palaia, Violante Di Donato, Federica Tomao, Ludovico Muzii, Giorgio Bogani, Ilaria Cuccu, Enrico Ciminello, Francesco Antonio Battaglia, Giusi Santangelo
Diagnostics.2025; 15(4): 463. CrossRef
The Role of 2D/3D Ultrasound to Assess the Response to Neoadjuvant Chemotherapy in Locally Advanced Cervical Cancer
Giorgia Perniola, Federica Tomao, Marialida Graziano, Innocenza Palaia, Margherita Fischetti, Francesca Lecce, Assunta Casorelli, Violante Di Donato, Antonella Giancotti, Francesco Antonio Battaglia, Ludovico Muzii, Pierluigi Benedetti Panici
Oncology.2020; 98(11): 807. CrossRef

4,531 View
20 Download
2 Crossref

Efficacy of Pre- and Postoperative Chemotherapy in Patients with Osteosarcoma of the Extremities: Joo Hyuk Sohn, Sun Young Rha, Hei Cheul Jeung, Hyun Joon Shin, Young Suck Goo, Hyun Cheol Chung, Woo Ick Yang, Soo Bong Hahn, Kyu Ho Shin, Jin Sik Min, Byung Soo Kim, Jae Kyung Roh, Woo Ick Jang; Cancer Res Treat. 2001;33(6):520-526. Published online December 31, 2001; DOI: https://doi.org/10.4143/crt.2001.33.6.520

Abstract PDF

PURPOSE
We evaluated the treatment efficacy including survival and recurrence, and factors associated with recurrence in osteosarcoma patients treated with preoperative chemotherapy, surgery, and adjuvant chemotherapy.
MATERIALS AND METHODS
Forty nine patients with osteosarcoma were treated with preoperative chemotherapy with intra-arterial cisplatin and adriamycin infusion for 3 cycles, followed by surgery. According to the pathologic response, if tumor was necrotized more than 90%, the same adjuvant chemotherapy was reintroduced for 3 cycles, and if the response was not enough, then the salvage regimen was introduced. Plain chest film and chest CT scan were taken monthly and every 3 months, respectively. When tumor recurred, the metastasectomy was performed whenever possible.
RESULTS
Forty three patients were evaluable with amedian follow up of 53 months. Five-year disease-free and overallsurvival rate was 47.0% and 66.9%, respectively. The recurrence was observed in 22 patients (51.2%) with median time of 12.5 months. Baseline alkaline phosphatase (ALP) was the only significant factor for recurrence (p=0.03) and the patients with the possibility of metastasectomy recurrence showed higher post-relapse survival compared to other treatment modalities (26 momths vs 5~12 months).
CONCLUSION
These results indicates that pre- and postoperative chemotherapy with intra-arterial cisplatin and adriamycin infusion showed comparable treatment efficacy and acceptable toxicities.

Citations

Citations to this article as recorded by

Loading comparison of two structures in the moving tube of a non-invasive prosthesis
Jie Zhang, Ping Ye, Lizheng Zhang, Hongliu Wu, Tianxi Chi, Zhaohua Chang
Technology and Health Care.2021; 29(5): 1001. CrossRef
The multidisciplinary treatment of osteosarcoma of the proximal tibia: a retrospective study
Junqi Huang, Wenzhi Bi, Gang Han, Jinpeng Jia, Meng Xu, Wei Wang
BMC Musculoskeletal Disorders.2018;[Epub] CrossRef
Expression change of ezrin as a prognostic factor in primary osteosarcoma
Yao Fei Wang, Jing Nan Shen, Xian Biao Xie, Jin Wang, Gang Huang
Medical Oncology.2011; 28(S1): 636. CrossRef
Comparison of Long-Term Outcome between Doublet and Triplet Neoadjuvant Chemotherapy in Non-Metastatic Osteosarcoma of the Extremity
Soojung Hong, Sang Joon Shin, Minkyu Jung, Jaeheon Jeong, Young Joo Lee, Kyoo-Ho Shin, Jae Kyung Roh, Sun Young Rha
Oncology.2011; 80(1-2): 107. CrossRef
Clinical Value of Ezrin Expression in Primary Osteosarcoma
Chan Kim, Eunah Shin, Soojung Hong, Hong Jae Chon, Hye Ryun Kim, Jung Ryun Ahn, Min Hee Hong, Woo Ick Yang, Jae Kyung Roh, Sun Young Rha
Cancer Research and Treatment.2009; 41(3): 138. CrossRef
Carboxypeptidase-G2 Rescue in a Patient with High Dose Methotrexate-induced Nephrotoxicity
Eun Sil Park, Kyung Hee Han, Hyoung Soo Choi, Hee Young Shin, Hyo Seop Ahn
Cancer Research and Treatment.2005; 37(2): 133. CrossRef

4,807 View
36 Download
6 Crossref

The Survival Rate of Stage IIB Ostosarcoma after Neoadjuvant Chemotherapy ( Modified T10 Protocol ): Jae Do Kim, Jeong Soo Bae, Myung Rae Cho; J Korean Cancer Assoc. 1998;30(3):591-598.

Abstract PDF: PURPOSE
The survival rate according to the methods of treatment was significantly higher in the osteosarcoma patients in which limb salvage operation with neoadjuvant chemotheraphy. The purpose of this study is to analyze the results of treatment in the Stage IIB osteosarcoma patients who treated with modified T10 protocol.
MATERIALS AND METHODS
From Jun. 1990 to Oct. 1997, thirty eight cases of Enneking's stage IIB osteosarcoma in extremities, were treated with neoadjuvant chemotherapy by modified T10 protocol of Rosen. Their mean age was 22 years old (8 months to 55 years). And average duration of follow up is 29 months(10 manths to 88 months). The preoperative chemotherapy consisted of high dose methotrexate(HDMTX)(above 12 years old: 8 g/m2, below 12 years old: 12 g/m2), adriamycin(ADR)(30 mg/m2/day x 2), intraarterial cisplatin(CDDP)(100 mg/m2) or ifosfamide (IFO)(1.8 g/m2/day x5). The preoperative tailoring was performed according to the radiologic response after chemotherapy. If the patient revealed good response, we continued the chemotherapy next one more cycle and if not, stoped the chemotherapy or changed the cisplatin to ifosfamide. The postoperative chemotherapy consisted of HDMTX, adriamycin, ifosfamide or cisplatin with 4 cycles. According to the pathologic response to the pre-operative chemotherapy, we use HDMTX, ADR, CDDP in good response group and HDMTX, ADR, IFO in poor response group respectively.
RESULTS
On the latest follow up, 27 patients were continuous disease free(CDF 27/38), 4 patients were alive with disease(AWD) and 6 patients were died of disease(DOD) and I case was died of bone marrow and hepatic failure due to complication of chemotherapy. According to Kaplan-Meier's plot, the overall 5 years survival rate was 73.6%, and continuous disease free 5 years survival rate being 64%. The comparison of continuous disease free survival rates between good radiologic response group and poor response group showed 73% and 55%. The continuous disease free survival rates according to the pathologic response in good response group and poor were 90 % and 55%. During the chemotherapy, the most serious complications were leukocytopenia and bone marrow failure. These were controled by granulocyte colony stimulating factor(G-CSF) and leukotrophic agent. Other minor complications were nausea, vomiting, headache and extrapyramidal symptom, which were easily managed by simple conservative measure.
CONCLUSION
It was obtained that the overall 5 years survival rate was 73.6%, and continuous disease free 5years survival rate being 64% with modified T10 protocol.

3,595 View
26 Download

The Effect of Neoadjuvant Chemotherapy with 5-Fluorouracil (5-FU), Vinblastine and Cisplatin (FVP) for Stage III Non-Small Cell Lung Cancer (NSCLC): Jung Il Won, Jong Ho Chun, Hyeong Jun Kim, Moon Suk Jo, Dong Kyu Kim, Young Tae Kwak, Jung Suk Kim, Soo Jeon Choi, Sung Rok Kim; J Korean Cancer Assoc. 1997;29(5):807-815.

Abstract PDF: PURPOSE
As the prognosis of stage III NSCLC is still poor with or without operation, we conducted a phase II trial of neoadjuvant chemotherapy (CHT) with 5-FU, vinblastine, cisplatin prior to surgery to determine the effect on resectability and survival.
MATERIALS AND METHOD
Patients (pt) received 5-FU 500mg/m2/12 hours continuous infusion for 36 hours, vinblastine 3mg/m2/day iv bolus day 1 and day 2, and cisplatin 75mg/m2 iv day 1 every 3 weeks. This regimen was given for 2 cycles. When the tumor was responsive (stable disease or better), 1 or 2 more cycles of the CHT were given, followed by operation when totally resectable on chest CT/MRI, then 3 more cycles of the CHT to finish the treatment; when the tumor was neither responsive nor resectable after 3rd or 4th CHT, radiotherapy was started.
RESULT
Twenty nine pt were enrolled and 26 pt have been evaluable so far. Age ranged from 32 to 79 (median 59 years); 23 were male, 3 female. Total of 108 cycles were given (mean 4.2). There were 4 partial remissions out of 6 IIIAs (67%) and 10 out of 20 IIIBs (50%), with overall response rate of 53.8%; down staging was noted in 9 patients (34.6%). 9 pt (34.6%) underwent curative resection successfully; 4 out of 6 IIIAs (67%) and 5 out of 20 IIIBs (25.0%); 1 patient refused operation. Median survival was 31.3 months for 9 pt with operation, and that of all patients was 14.2 months. Radiation was given to 9 pt, resulting in 3 partial remissions (PR), 3 stable diseases (SD), 3 progressive diseases (PD). Serious (WHO grade> or =3) toxicities were nausea/emesis in 2.8%, granulocytopenia in 26.9% and thrombocytopenia in 2.8%.
CONCLUSION
This treatment modality seemed to be effective, encouraging further phase III study for better determination of its role.

2,777 View
14 Download

Neoadjuvant Chemotherapy Combined Carboplatin in High Risk Carvial Cancer: Ho Sun Choi, Ji Soo Byun, Woong Ki Chung; J Korean Cancer Assoc. 1994;26(3):438-445.

Abstract PDF: Objective: Survival of patients with bulky cervical cancer treated with surgery or radiotherapy has been poor. This has led to the another therapeutic modality. Neoadjuvant chemotherapy with cisylatin combination has been employed extensively. Carboplatin is an an- alog of cisplatin with minimal nephrotoxicity and neurotoxicity at conventional dosage. The purpose of this study was to assess the local response and toxicity of carboplatin combination therapy for high risk cervical cancer. Methads: Neoadjuvant chemotherapy with carboplatin, vinblastin, bleomycin combination(20 patients) or cisplatin, vinblastin, bleomycin combination (20 patients)were tried to high risk squamous cell cancer of the uterine cervix. Randomization was well balanced for age, clinical stage and histologic type. Both drugs were given every 21 days with carboplatin 300 mg/m, vinblastin 4 mg/m(2), bleomycin 20 mg and cisplatin 75 mg/m, vinblastin 4 mg/m(2), bleomycin 20 mg. Results: The response rate of carboplatin combination and cisplatin combination were 25% and 30% of patients. The major toxic effects for carboplatin combination and cisplatin combination included nause and vomiting in 70% and 80% of patients, leukopenia in 40% and 60%, thrombocytopenia in 25% and l0%, and anemia in 35% and 40%, respectively. Conclusion: The activity of carboplatin combination for high risk cervical cancer is similar to the activity of cisplatin combination. However, the toxicity of the former is substantially better than that of the latter.

2,492 View
13 Download

Neoadjuvant Chemotherapy in Locally Advanced Non - Small Cell Lung Cancer: Hai Jung Cho, Kyoung Sang Shin, Sang Ki Park, Ae Kyung Kim, Jong Jin Lee, Nam Jae Kim, Jee Won Seo, Ju Ock Kim, Seung Pyung Lim, Sun Young Kim; J Korean Cancer Assoc. 1995;27(4):608-620.

PDF

3,467 View
20 Download

Neoadjuvant Chemotherapy with 5-Fluorouracil and Cisplatin for Locally Advanced Head and Neck Cancer: Ji Hoon Park, Hwan Suk Choi, Jeong Hee Kim, Si Young Kim, Hwi Joong Yoon, Kyung Sam Cho, Seong Eon Hong, Dong Mok Ryu, Hoe Young Ahn; J Korean Cancer Assoc. 1995;27(6):990-1002.

Abstract PDF: Background
The prognosis for patients with locally advanced head and neck cancer remains poor. In recent years, attempts at improving the poor survival rates have frquently focused on the initial use of chemotherapy followed by subsequent standard local therapy with surgery and radiation. Methods: Twenty-seven patients with previously untreated, locally advanced (stage III or IV) head and neck cancer were treated with 2 or 3 cycles of combination chemotherapy consisting of 5-fluorouracil infusion and cisplatin followed by operation or radiotherapy between January,1988 and March,1994. Results: 1) After the neoadjuvant FP chemotherapy, sixteen of 27 patients(59.2%) demonstrated an objective response, with one(3.7%) achieving a complete clinical response(CR) and fifteen(55.5%) a partial response(PR). After the definitive local therapy(DLT:operation or radiation therapy), 12(44.4%) patients had a CR and 12(44.4%) achieved PR, respectively with 88.8% overall response rates. 2) Twelve patients received operation and 15 patients received radiotherapy after the neoadjuvant chemotherapy. Among 12 patients who received operation, seven(58%) patients achieved curative resection with surgery and five(33%) patients a complete remission, seven patients(46.7%) a partial remission with radiotherapy. 3) The overall median survival of total 27 patients was 31 months. The median survival of the responders (median:54 months) to FP chemotherapy was not significantly prolonged compared with nonresponders(median:23 months). 4) Time to disease progression of the responders to definite local therapy was 19 months. 5) Leukopenia and thrombocytopenia were observed in 48%(grade I-III) and l0%(grade I- II) respectively. Nausea and vomiting were observed in all patients, but easily controlled. Alopecia, diarrhea, stomatitis and nephrotoxicity were observed infrequently. There were no treatment related fatalities. Conclusion: Neoadjuvant FP chemotherapy in patients with locally advanced head and neck cancer was tolerable, but did not improve the response rate and overall survival compared with previous other reports. The phase III randomized controlled prospective studies are warranted for the verification of this study

3,136 View
17 Download

Neoadjuvant Chemotherapy with High-dose Methotrexate , Adriamycin and Cisplatin for Non - Metastatic Osteosarcoma: Keun Seok Lee, Heung Moon Chang, Dae Seog Heo, Yung Jue Bang, Noe Kyeong Kim, Sang Hoon Lee, Eui Keun Ham, Han Ku Lee; J Korean Cancer Assoc. 1996;28(6):1092-1104.

Abstract PDF: three non-metastatic osteosarcoma patients were treated with high-dose methotrexate, adriamycin, and cisplatin from October 1987 to May 1993. Median age was 18. The ratio of male to female was 16: 7. The patients received methotrexate 8g/§³ IV, day 1 and 8 with leucovorin rescue, adriamycin 25mg/§³ IV day 16~18, and cisplatin 75mg/§³ IV day 16, After two cycles of neoadjuvant chemotherapy, operation was done and then six cycles of adjuvant chemotherapy were given with the same regimen. One patient developed lung metastasis after two cycles of neoadjuvant chemotherapy, and the other patient died from sepsis associated with chemotherapy-induced neutropenia before operation. Therefore, 21 patients underwent operation. Among them, l9 patients underwent limb salvage operation. Of the five patients who relapsed, two patients had lung metastasis and another two patients had local recurrence, and one patient had both lung and brain metastasis. One year, three year, and five year disease-free survival rate were 84%, 68%, and 68%. One year, three year, and five year survival rate were 91%, 64%, and 53%, respectively. The site of the primary lesion was the only significant prognosis factor. Patients with the lesion of distal femur had poor prognosis.Histologic responses were assessed in 17 patients. Observed histologic responses were grade I necrosis in 35%, grade II necrosis in 65%. There was no grade III or IV necrosis. The disease-free survival rates and overall survival rates were not significantly different between grade I necrosis group and grade II necrosis group. Toxicities grade III or IV were as follows: leukopenia 32%, thrombocytopenia 9%, hepatotoxicity 14%, and infection 6% with one chemotherapy-related death. The pharmacokinetics of high-dose methotrexate with leucovorin rescue were studied in l0 patients. The highest concentration was achieved at the end of infusion(6 hour). The decay of the plasma concentration of methotrexate after completion of the infusion followed a two-compartment model with a T(1/2)￥a of 3.4¡¾1.9 hours and T(1/2)￥a of 8.0¡¾2.6 hours. The clearance was 55¡¾13ml/min/§³ and the volume of distribution was 8.2¡¾3.0 L/§³. In conclusion, neoadjuvant chemotherapy with high-dose methotrexate, adriamycin, and cisplatin is effective for treatment of the patients of osteosarcoma with preserving the limb function.

2,942 View
17 Download

First
Prev
Page of 1
Next
Last

Search