KCA
Search
- Page Path
- HOME > Search
Original Articles
- Neutrophil-to-Lymphocyte Ratio and Extrahepatic Spread Predict Response and Survival in Unresectable Hepatocellular Carcinoma
- Dong Yun Kim, Heechul Nam, Jun Yong Park, Sang Hoon Ahn, Sung Won Lee, Do Young Kim
- Received May 8, 2026 Accepted July 3, 2026 Published online July 7, 2026
- DOI: https://doi.org/10.4143/crt.2026.0498 [Accepted]
-
Abstract
PDF - Purpose
Identifying nonresponders to atezolizumab plus bevacizumab (AB) remains challenging in unresectable hepatocellular carcinoma (uHCC). We aimed to develop and externally validate a simple risk scoring system using baseline neutrophil-to-lymphocyte ratio (NLR) and extrahepatic spread (EHS) to predict treatment outcomes.
Materials and Methods
We included 304 patients with uHCC receiving first-line AB from multiple Korean centers (discovery, n = 220; validation, n = 84). Study outcomes included objective response rate (ORR) assessed by modified Response Evaluation Criteria in Solid Tumors, overall survival (OS), and progression-free survival (PFS). Multivariable analysis identified high NLR (>4.575) and EHS as independent predictors of nonresponse. The NLR-EHS score assigned 2 points for high NLR and 1 point for EHS (range, 0–3).
Results
In the discovery cohort, the score predicted nonresponse with an area under the receiver operating characteristic curve (AUC) of 0.749 (95% CI, 0.688–0.810); ORR fell across low- (0), moderate- (1–2), and high-risk (3) groups (67.3%, 47.7%, and 8.2%; p < 0.001). Validation confirmed comparable discrimination (AUC, 0.705; 95% CI, 0.603–0.806) and a consistent ORR gradient (77.8%, 54.2%, and 22.2%; p < 0.001). The score was prognostic for OS in discovery (HR, 1.28; p = 0.003) and validation cohorts (HR, 1.45; p = 0.007), remaining significant after adjustment (adjusted HR, 1.25 and 1.61, respectively). High-risk patients had inferior median OS (6.9 vs. 17.1 months in validation).
Conclusion
The NLR-EHS score is a practical tool for stratifying nonresponse risk and survival in uHCC patients receiving AB, facilitating early identification of high-risk patients who may benefit from alternative strategies.
- 462 View
- 40 Download
- Pediatric cancer
- Malignant Hepatocellular Neoplasm, Not Otherwise Specified, Displays Poorer Chemoresponsiveness and Postoperative Prognosis Than Hepatoblastoma
- In Hye Song, Sujin Gang, Hee Mang Yoon, Pyeong Hwa Kim, Bokyung Ahn, Jihun Kim, Deok Hoon Kim, Jung-Man Namgoong, Kyung-Nam Koh
- Cancer Res Treat. 2026;58(2):642-655. Published online May 12, 2025
- DOI: https://doi.org/10.4143/crt.2025.117
-
Abstract
PDF
Supplementary Material
PubReader
ePub - Purpose
Malignant hepatocellular neoplasm, not otherwise specified (HCN-NOS) is a provisional diagnostic entity, characterised by intermediate or a combination of hepatoblastoma and pediatric hepatocellular carcinoma (p-HCC) features. We compared the characteristics of HCN-NOS with hepatoblastoma and p-HCC.
Materials and Methods
The records of 148 pediatric patients diagnosed with hepatocellular malignancy after resection were retrieved from the institutional database. Clinical parameters and histopathology slides were reviewed to re-establish each patient’s diagnosis. Molecular analyses were conducted in 37 patients.
Results
Patients were profiled as 21 (14.2%) with HCN-NOS, 109 (73.6%) with hepatoblastoma, and 18 (12.2%) with p-HCC. The median age was 8.6 years in HCN-NOS, 1.2 years in hepatoblastoma, and 7.9 years in p-HCC. Background liver disease was frequently observed in p-HCC (11/18, 61%) but infrequent in HCN-NOS (4/21, 19%) and hepatoblastoma (4/109, 3.7%). HCN-NOS presented with a more advanced PRETEXT stage (p=0.012), metastasis (p < 0.001), and lymphovascular invasion (p < 0.001) than hepatoblastoma and p-HCC. Patients with HCN-NOS received longer cycles of preoperative chemotherapy; however, they reported a lower decrease in serum alpha-fetoprotein and tumor size than hepatoblastoma (p=0.043, p=0.004, and p=0.044, respectively). HCN-NOS was an independent poor prognostic factor for event-free survival (hazard ratio, 4.968; 95% confidence interval, 2.004 to 12.32; p < 0.001).
Conclusion
The possibility of HCN-NOS should be considered in pediatric patients with liver cancer, especially those ≥ 5 years old with no background liver disease. Because HCN-NOS exhibits poor chemoresponsiveness and unfavourable postoperative prognosis, liver transplantation should be strongly considered. -
Citations
Citations to this article as recorded by
- Conversion Hepatectomy After New FP Therapy for Malignant Hepatocellular Neoplasm, Not Otherwise Specified: A Case Report
Etsuko Moriyama, Hironori Koga, Takashi Niizeki, Hideki Iwamoto, Shigeo Shimose, Tomotake Shirono, Takahiko Tokushige, Masahito Nakano, Ryoko Kuromatsu, Toru Goto, Masaki Honda, Taizo Hibi, Yoshiki Mikami, Reiichiro Kondo, Jun Akiba, Takumi Kawaguchi
Hepatology Research.2026; 56(6): 1047. CrossRef
- Conversion Hepatectomy After New FP Therapy for Malignant Hepatocellular Neoplasm, Not Otherwise Specified: A Case Report
- 4,601 View
- 182 Download
- 1 Web of Science
- 1 Crossref
Special Article
- Trends in Cancer-Screening Rates in Korea: Findings from the National Cancer Screening Survey, 2004-2023
- EunKyo Kang, Kui Son Choi, Jae Kwan Jun, Yeol Kim, Hyeon Ji Lee, Chang Kyun Choi, Tae Hee Kim, Sun Hwa Lee, Mina Suh
- Cancer Res Treat. 2025;57(1):28-38. Published online August 2, 2024
- DOI: https://doi.org/10.4143/crt.2024.325
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
This study aimed to report the overall national trends in the rates of cancer screening based on recommendations and provide insights into the changing trends of these rates across different demographics.
Materials and Methods
This study used data from the Korean National Cancer Screening Survey (KNCSS), which surveys nationwide cancer-screening rates and includes 4,500 individuals meeting the Korean National Cancer Screening Program (NCSP) protocol age criteria. Cancer-screening rates were assessed using structured questionnaires; yearly trends were analyzed for both lifetime cancer-screening rates and rates of screening based on recommendations, and subgroup analyses were performed based on age and sex.
Results
The rates of cancer screening based on recommendations showed significant increments: the stomach cancer-screening rate increased from 39.2% in 2004 to 77.5% in 2023 (3.50% per year), the liver cancer-screening rate increased from 20.0% to 48.8% (4.30% per year), and the colorectal cancer, increased from 19.9% to 70.7% (5.15% per year). The breast cancer-screening rate increased from 33.2% to 72.7% (2.88% per year), and the cervical cancer, increased from 58.3% to 70.2% (1.08% per year). Despite some differences, particularly in relation to sociodemographic factors, screening rates increased significantly for all cancer types.
Conclusion
Cancer-screening rates in Korea increased consistently from 2004 to 2023, demonstrating the effectiveness of the national cancer-screening program. However, the increments in breast, cervical and lung cancer-screening rates were relatively lower, indicating the need for additional efforts and strategies. -
Citations
Citations to this article as recorded by- Optimal interval of screening endoscopy for reducing gastric cancer mortality: a nationwide cohort study
Soo-Yoon Sung, Hyun Ho Choi, Seung Ho Sin, Hyung-Keun Kim, Sang Woo Kim, Sung Soo Kim
Gastrointestinal Endoscopy.2026; 103(4): 725. CrossRef - Practice of Cytopathology in Korea: A 40‐Year Evolution Through Standardization, Digital Transformation, and Global Partnership
Yosep Chong, Ran Hong, Hyeong Ju Kwon, Haeryoung Kim, Lucia Kim, Soon Jae Kim, Yoon Jung Choi
Diagnostic Cytopathology.2026; 54(2): 146. CrossRef - Information Landscape on Cervical Cancer: An Analysis of News and Online Platform Data in the Republic of Korea
Hye-Sun Lee, Gyeong-U Hong, Wonjeong Jeong, Kyounghee Oh, Jae Kwan Jun
Health Communication.2026; 41(10): 1708. CrossRef - Persistent income-related inequalities in cancer screening utilisation in South Korea: Evidence from repeated cross-sectional data, 2013–2023
Soyun An, Sunghyun Yi, Jihyung Hong
Public Health.2026; 252: 106157. CrossRef - Racial/ethnic and geographic differences in second primary cancers in stomach cancer survivors: a comparative study of U.S. and South Korea
Yuntong Wang, Dong-Woo Choi, Sangwon Lee, Jialin Mao, Art Sedrakyan, Xiang Shu, Kui Son Choi, Heejung Chae, Eunji Choi
Gastric Cancer.2026; 29(3): 506. CrossRef - The impact of an organized screening program on gastric cancer incidence: a quasi-experimental study
Dianqin Sun, Duco T Mülder, Kyu-Won Jung, Jin Young Park, Mina Suh, Yige Li, Daan Nieboer, Chisato Hamashima, Weiran Han, Manon C W Spaander, Uri Ladabaum, Robert J Huang, James F O’Mahony, Iris Lansdorp-Vogelaar
International Journal of Epidemiology.2026;[Epub] CrossRef - International trends in cancer mortality revisited: Japan’s site-specific progress and remaining challenges until 2024
Kota Katanoda, Hirokazu Tanaka, Yuri Ito
Japanese Journal of Clinical Oncology.2026; 56(6): 787. CrossRef - Temporal trends and future projections of colorectal cancer burden in East Asia: an analysis of GBD 2021 data for China, South Korea, and Japan (1990–2050)
Yuren Zhang, Yongchao Zhang, Keqiang Lu, Huirong Zhu
International Journal of Surgery.2026; 112(3): 8164. CrossRef - Source-specific short-term-ozone exposure and specific cancer mortality risk: A multi-country study in 11,215 communities
Pei Yu, Rongbin Xu, Wenzhong Huang, Yanming Liu, Zhengyu Yang, Michael J. Abramson, Eric Lavigne, Simon Hales, Lidia Morawska, Paulo H.N. Saldiva, Fay H. Johnston, Luke Knibbs, Geoffrey Morgan, Guy B. Marks, Jane Heyworth, Ho Kim, Kraichat Tantrakarnapa,
Journal of Hazardous Materials.2026; 508: 141822. CrossRef - Population Colorectal Cancer Screening in Asia: Insights From Established Programs
Wen‐Feng Hsu, Masau Sekiguchi, Jeongkuk Seo, Hyun‐Soo Kim, Takahisa Matsuda, Han‐Mo Chiu
Journal of Gastroenterology and Hepatology.2026; 41(5): 1415. CrossRef - Impact of South Korea’s national gastrointestinal cancer screening programme on incidence and mortality: a population-based difference-in-differences study
Jaewoo Cha, Minku Kang
BMJ Open.2026; 16(4): e112558. CrossRef - Detección precoz del cáncer colorrectal
Alejandro J. Zárate, Suraj Samtani, Roberto Salas, Camila Leiva
Revista Médica Clínica Las Condes.2026; 37(2): 147. CrossRef - Global inequalities in tracheal, bronchus, and lung cancer care quality from 1990 to 2021
Yafen Wang, Enhui Zhou, Zhengyu Shi, Weijun Huang, Tianjiao Zhou, Chen Xu, Jinxiu Yao, Jing Wang, Siqiong Jiang, Fang Fang, Wen Lu, Hongliang Yi
iScience.2026; 29(7): 116604. CrossRef - Understanding barriers and facilitators to cervical cancer prevention among young Korean Women: A focus group interview study
Hyun Jin Kim, Hyeon Ji Lee, Hye Young Shin, Hye-Sun Lee, Jae Kwan Jun, Kui Son Choi, Mina Suh, Fatemeh Zarei
PLOS One.2026; 21(7): e0353242. CrossRef - Decline in Years of Life Lost Due to Diabetes in Korea, 2008–2019: A Cause-Specific Decomposition Analysis
Da Hea Seo, Kyoung Hwa Ha, Dae Jung Kim
Endocrinology and Metabolism.2026; 41(4): 558. CrossRef - Emerging cancer incidence trends in younger generations: age-specific trends and birth cohort effects from 25 years of Korean Cancer Registry data
Bohyun Park, Hye Ah Lee, Bomi Park, Hyesook Park
Cancer Epidemiology.2026; 104: 103209. CrossRef - Association Between Suicidal Ideation and Cancer Screening Uptake: Results from Middle-Aged and Older Adults in Korea
Seong-Uk Baek, Jin-Ha Yoon
Cancers.2025; 17(6): 956. CrossRef - From pilot to policy: what Korea’s LDCT program teaches us about National Lung Cancer Screening
Lisa Jungblut
European Radiology.2025; 35(12): 8162. CrossRef - Current Status of the National Cancer Screening Program in Korea: History, Achievements, and Future Directions
Kyeongmin Lee, Mina Suh, Kui Son Choi
Journal of Preventive Medicine and Public Health.2025; 58(4): 337. CrossRef - Inequalities in breast cancer incidence and mortality in women with and without disabilities in South Korea: A population-based cohort study
Hee-Yeon Kang, Eunjung Park, Thi Tra Bui, Byungmi Kim, Jin-Kyoung Oh
Preventive Medicine Reports.2025; 59: 103242. CrossRef - Presentation of Benefits and Harms in Cancer Screening Guidelines for Koreans: A Systematic Review
Mi Ah Han, Hunju Lee, Kwangmin Kim, Seong Jung Kim, Eu Chang Hwang, Jae Hung Jung
Cancer Research and Treatment.2025; 57(4): 923. CrossRef - Association of Elevated Serum Triglycerides with Colorectal Cancer Risk: Findings from a Large-scale Prospective Cohort of Korean Adults
Sukhong Min, Hyobin Lee, Sinyoung Cho, Seung-Yong Jeong, Aesun Shin, Daehee Kang
Cancer Prevention Research.2025; 18(11): 681. CrossRef
- Optimal interval of screening endoscopy for reducing gastric cancer mortality: a nationwide cohort study
- 9,112 View
- 303 Download
- 22 Web of Science
- 22 Crossref
Original Articles
- Gastrointestinal Cancer
- Fasting Blood Glucose, Cholesterol, and Risk of Primary Liver Cancer: The Kailuan Study
- Xiangming Ma, Haozhe Cui, Miaomiao Sun, Qian Liu, Xining Liu, Guangjian Li, Yaochen Wei, Qingjiang Fu, Siqing Liu, Liying Cao
- Cancer Res Treat. 2021;53(4):1113-1122. Published online January 19, 2021
- DOI: https://doi.org/10.4143/crt.2020.817
-
Abstract
PDFPubReaderePub
- Purpose
The influence of fasting blood glucose (FBG) and cholesterolemia primary liver cancer (PLC) in china was analyzed via a large prospective cohort study based on a community population, and the combined effects between them were investigated.
Materials and Methods
Overall, 98,936 staff from the Kailuan Group who participated in and finished physical examinations between 2006 and 2007 were included in the cohort study. Their medical information was collected and they were followed up after examination. The correlations of serum FBG or TC with PLC were analyzed. Then, we categorized all staff into four groups: normal FBG/ non-hypocholesterolemia, normal FBG/hypocholesterolemia, elevated FBG/non-hypocholesterolemia, elevated FBG/hypocholesterolemia and normal FBG/ non-hypocholesterolemia was used as a control group. The combined effects of elevated FBG and hypocholesterolemia with PLC were analyzed using the Age-scale Cox proportional hazard regression model.
Results
During 1,134,843.68 person*years follow up, a total of 388 PLC cases occured. We found the elevated FBG and hypocholesterolemia increases the risk for PLC, respectively. Compared with the non-hypocholesterolemia/normal FBG group, the risk of PLC was significantly increased in the non-hypocholesterolemia/elevated FBG group (HR=1.19,95%CI 0.88–1.62) and hypocholesterolemia/normal FBG group (HR=1.53,95%CI 1.19–1.97), and in the hypocholesterolemia/elevated FBG group (HR=3.16 95%CI2.13-4.69). And, a significant interaction effect was found of FBG and TC on PLC. All results were independent from the influence of liver disease.
Conclusion
Elevated serum FBG and hypocholesterolemia are risk factors for PLC, especially when combined. Thus, for the prevention and treatment of PLC, serum FBG and TC levels should be investigated. -
Citations
Citations to this article as recorded by- The role of glucose-6-phosphatase activity in glucose homeostasis and its potential for diabetes therapy
Lay Shuen Tan, Hwee Hui Lau, Essam M. Abdelalim, Chin Meng Khoo, Richard M. O’Brien, E. Shyong Tai, Adrian Kee Keong Teo
Trends in Molecular Medicine.2025; 31(2): 152. CrossRef - Causality of blood metabolites on hepatocellular carcinoma and cholangiocarcinoma: a metabolome-wide mendelian randomization study
Lin Ning, Zhanhua Gao, Di Chen, Jie Han, Guanyue Xie, Jianguang Sun
BMC Cancer.2025;[Epub] CrossRef - Impact of Dietary Behavioural Changes on Prognosis of Postoperative Oesophageal Squamous Cell Carcinoma Patients: A Retrospective Cohort Study
Fengqing Ji, Yunyun Chen, Yan Ma, Haiyan Wu, Xinqi Wei, Zhiyun Xu, Jianqiang Zhao
Nursing Open.2025;[Epub] CrossRef - Health Outcomes Associated with Hypolipidemia: a Scoping Review
Seungcheol Hong, Dong-jun Choi, Ji-cheon Jeong
The Journal of Internal Korean Medicine.2025; 46(1): 61. CrossRef - A burden of proof study of the effects of exposure to high fasting plasma glucose on the risk of seven types of cancer
Paula Portal Teixeira, Yvonne Yiru Xu, Aleksandr Aravkin, Peng Zheng, Lisa M. Force, Jonathan Kocarnik, Susan McLaughlin, Theo Vos, Hailey Lenox, Simon I. Hay, Bruce Bartholow Duncan, Verônica Colpani, Chris Murray, Fernando Gerchman, Kanyin Liane Ong
Scientific Reports.2025;[Epub] CrossRef - Impact of high fasting plasma glucose on liver cancer burden in China: a comprehensive analysis of trends from 1990 to 2021
Zhouwei Zhan, Wei Lin, Xintong Yao, Shuqi Huang, Shuangting Lan, Lina Zheng, Zengqing Guo, Bijuan Chen
Frontiers in Nutrition.2025;[Epub] CrossRef - Inverse association between serum lipid profiles and hepatocellular carcinoma risk: a meta-analysis of epidemiological studies
Chongshi Zeng, Shuran Liu, Haining Li, Xiao Han
Frontiers in Oncology.2025;[Epub] CrossRef - Association between Metabolically Healthy Status and Risk of Gastrointestinal Cancer
Haozhe Cui, Fei Tian, Yongliang Chen, Xiangming Ma
Cancer Research and Treatment.2024; 56(1): 238. CrossRef - Identification of structural motifs critical for human G6PC2 function informed by sequence analysis and an AlphaFold2-predicted model
Emily M. Hawes, Derek P. Claxton, James K. Oeser, Richard M. O’Brien
Bioscience Reports.2024;[Epub] CrossRef - Primary hypocholesterolemia is associated with an increased risk of hepatic complications in the general population
Matthieu Wargny, Thomas Goronflot, Antoine Rimbert, Jérôme Boursier, Sofiane Kab, Joseph Henny, Antoine Lainé, Christophe Leux, Sarra Smati, Samy Hadjadj, Cédric Le May, Marcel Goldberg, Marie Zins, Bertrand Cariou
Journal of Hepatology.2024; 80(6): 846. CrossRef - Biochemical and metabolic characterization of a G6PC2 inhibitor
Emily M. Hawes, Mohsin Rahim, Zeinab Haratipour, Abigail R. Orun, Margaret L. O'Rourke, James K. Oeser, Kwangho Kim, Derek P. Claxton, Ray D. Blind, Jamey D. Young, Richard M. O'Brien
Biochimie.2024; 222: 109. CrossRef - Nanomaterials modulate tumor-associated macrophages for the treatment of digestive system tumors
Hao Li, Shuai Wang, Zhengqiang Yang, Xianwei Meng, Meng Niu
Bioactive Materials.2024; 36: 376. CrossRef - Association between transitions in metabolic health and colorectal cancer across categories of body size phenotype: a prospective cohort study
Qian Liu, Fei Si, Yuntao Wu, Jing Yu
Obesity.2024; 32(10): 1948. CrossRef - Prognostic value of AFP-L3 and Des-γ-carboxy prothrombin in advanced primary liver cancer treated with Sorafenib and transarterial chemoembolization
Shiwen Tang
American Journal of Translational Research.2024; 16(9): 5004. CrossRef - Abdominal obesity, chronic inflammation and the risk of non-alcoholic fatty liver disease
Dongna Zhao, Haozhe Cui, Zhiqiang Shao, Liying Cao
Annals of Hepatology.2023; 28(4): 100726. CrossRef - Fasting plasma glucose and alanine aminotransferase on the risk of hepatocellular carcinoma: A nested case-control study
Lizhen Zhang, Zhongge Wang, Ruirui Chen, Zhiyuan Cheng, Jingli Yang, Jing Li, Siyu Li, Yarong Chen, Lulu Xu, Yujia Hu, Yana Bai
Cancer Epidemiology.2023; 84: 102362. CrossRef - Lipids, cholesterols, statins and liver cancer: a Mendelian randomization study
Zicheng Liang, Zhen Zhang, Xiaoning Tan, Puhua Zeng
Frontiers in Oncology.2023;[Epub] CrossRef - Triglyceride-glucose index associated with the risk of cardiovascular disease: the Kailuan study
Qian Liu, Haozhe Cui, Yihan Ma, Xu Han, Zhiwei Cao, Yuntao Wu
Endocrine.2022; 75(2): 392. CrossRef - Cumulative triglyceride-glucose index is a risk for CVD: a prospective cohort study
Haozhe Cui, Qian Liu, Yuntao Wu, Liying Cao
Cardiovascular Diabetology.2022;[Epub] CrossRef - Association of triglyceride–glucose index and traditional risk factors with cardiovascular disease among non-diabetic population: a 10-year prospective cohort study
Li Liu, Zhenguo Wu, Yifan Zhuang, Yerui Zhang, Huiliang Cui, Fanghong Lu, Jie Peng, Jianmin Yang
Cardiovascular Diabetology.2022;[Epub] CrossRef
- The role of glucose-6-phosphatase activity in glucose homeostasis and its potential for diabetes therapy
- 10,577 View
- 126 Download
- 19 Web of Science
- 20 Crossref
- General
- Trends in Cancer Screening Rates among Korean Men and Women: Results of the Korean National Cancer Screening Survey, 2004–2018
- Seri Hong, Yun Yeong Lee, Jaeho Lee, Yeol Kim, Kui Son Choi, Jae Kwan Jun, Mina Suh
- Cancer Res Treat. 2021;53(2):330-338. Published online October 20, 2020
- DOI: https://doi.org/10.4143/crt.2020.263
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
The Korean National Cancer Screening Survey (KNCSS) is a nationwide annual cross-sectional survey conducted for the past 15 years. This study aimed to report trends in the overall screening rates of both organized and opportunistic cancer screening programs from 2004–2018.
Materials and Methods
KNCSS data were collected using a structured questionnaire. For five major cancers (i.e., stomach, liver, colorectal, breast, and cervical cancer), we evaluated both the lifetime screening rate and the screening rate with recommendations. The study population included men aged 40–74 years and women aged 20–74 years with no cancer histories.
Results
Screening rate with recommendations increased from 2004 annually by 4.4% and 1.5% until 2013 for stomach and liver cancers, respectively, by 4.0% until 2012 for breast cancer, and by 3.6% and 1.2% until 2014 for colorectal and cervical cancers, respectively, followed by nonsignificant trends thereafter. In 2018, screening rates with recommendations for these cancers were 72.8%, 26.2%, 63.1%, 58.4%, and 55.6%, respectively.
Conclusion
Screening rates for the five types of cancer demonstrated a marked increase between 2004 and 2018. However, many recent screening rates have been flattened with nonsignificant trends, and there are lower rates for cervical cancer screening among young age groups. Steady efforts are needed to achieve higher screening participation rates overall, especially for the cervical cancer screening of young women in their 20s. -
Citations
Citations to this article as recorded by- Information Landscape on Cervical Cancer: An Analysis of News and Online Platform Data in the Republic of Korea
Hye-Sun Lee, Gyeong-U Hong, Wonjeong Jeong, Kyounghee Oh, Jae Kwan Jun
Health Communication.2026; 41(10): 1708. CrossRef - Knowledge, Beliefs, and Behaviors Regarding Colorectal Cancer Screening Among Koreans
Shin-Young Lee
Healthcare.2026; 14(3): 344. CrossRef - The impact of an organized screening program on gastric cancer incidence: a quasi-experimental study
Dianqin Sun, Duco T Mülder, Kyu-Won Jung, Jin Young Park, Mina Suh, Yige Li, Daan Nieboer, Chisato Hamashima, Weiran Han, Manon C W Spaander, Uri Ladabaum, Robert J Huang, James F O’Mahony, Iris Lansdorp-Vogelaar
International Journal of Epidemiology.2026;[Epub] CrossRef - Association between blood type and pulmonary thromboembolism in patients with gastric cancer: A retrospective cohort study
Joonpyo Lee, Youngwoo Jang, Kilyoon Pack, Taeil Yang, Yoonsun Won, Kyung Eun Ha, Young Saing Kim, Jeonggeun Moon
Journal of International Medical Research.2026;[Epub] CrossRef - Advancing Gastric Cancer Prevention in Korea: Current Strategies and Future Directions
Jin Young Park, Il Ju Choi
Helicobacter.2026;[Epub] CrossRef - Patterns of multiple primary malignancies in patients with head and neck cancer: a 20-year single-institution cohort study
Hye-Bin Jang, Dong Hoon Lee
European Archives of Oto-Rhino-Laryngology.2026; 283(8): 5255. CrossRef - A cross-national investigation of CT, MRI, PET, mammography, and radiation therapy resources and utilization
Takahiro Aoyama, Yutaro Koide, Hidetoshi Shimizu, Atsushi Urikura, Tomoki Kitagawa, Shingo Hashimoto, Hiroyuki Tachibana, Takeshi Kodaira
Japanese Journal of Radiology.2025; 43(1): 109. CrossRef - Current and future burden of breast cancer in Asia: A GLOBOCAN data analysis for 2022 and 2050
Mengxia Fu, Zhiming Peng, Min Wu, Dapeng Lv, Yanping Li, Shuzhen Lyu
The Breast.2025; 79: 103835. CrossRef - Trends in Cancer-Screening Rates in Korea: Findings from the National Cancer Screening Survey, 2004-2023
EunKyo Kang, Kui Son Choi, Jae Kwan Jun, Yeol Kim, Hyeon Ji Lee, Chang Kyun Choi, Tae Hee Kim, Sun Hwa Lee, Mina Suh
Cancer Research and Treatment.2025; 57(1): 28. CrossRef - Korean Gastric Cancer Association-Led Nationwide Survey on Surgically Treated Gastric Cancers in 2023
Dong Jin Kim, Jeong Ho Song, Ji-Hyeon Park, Sojung Kim, Sin Hye Park, Cheol Min Shin, Yoonjin Kwak, Kyunghye Bang, Chung-sik Gong, Sung Eun Oh, Yoo Min Kim, Young Suk Park, Jeesun Kim, Ji Eun Jung, Mi Ran Jung, Bang Wool Eom, Ki Bum Park, Jae Hun Chung, S
Journal of Gastric Cancer.2025; 25(1): 115. CrossRef - Association Between Levonorgestrel-Releasing Intrauterine System Exposure Duration and Breast Cancer Incidence
Jin-Sung Yuk, Myoung Hwan Kim, Sang Hee Yoon, Gwan Hee Han, Ji Hyun Noh
Obstetrics & Gynecology.2025; 145(5): 523. CrossRef - Determinants of Prostate Cancer Screening in Korean Men: A Nationwide Study Using the Korean National Cancer Screening Survey 2023
Giap Viet Nguyen, Kyeongmin Lee, Hyeon Ji Lee, EunKyo Kang, Mina Suh, Jae Kwan Jun, Kui Son Choi
Cancer Research and Treatment.2025; 57(2): 539. CrossRef - Temporal trend in non-melanoma skin cancer mortality in China, 1992–2021: an analysis for the global burden of disease study 2021
Deng Li, Ge Yan, Shasha Song, Siqi Fan, Haochen Zhao, Gang Hu, Xuewen Xu, Qingfeng Li
Frontiers in Medicine.2025;[Epub] CrossRef - Global colorectal cancer screening programs and coverage rate estimation: an evidence synthesis
Yuqing Chen, Yuelun Zhang, Yike Yan, Jingjing Han, Li Zhang, Xinran Cheng, Bin Lu, Na Li, Chenyu Luo, Yueyang Zhou, Kai Song, Motoki Iwasaki, Min Dai, Dong Wu, Hongda Chen
Journal of Translational Medicine.2025;[Epub] CrossRef - Prediction of upstaging in DCIS: the dominant role of pathological over imaging risk factors
Sunhyung Choi, Bombi Park, Eun-Gyeong Lee, Seeyoun Lee, Han-Sung Kang, So-Youn Jung, Dong-Eun Lee, Jai-Hong Han
Breast Cancer Research and Treatment.2025; 213(3): 325. CrossRef - Socioeconomic inequality in organized and opportunistic screening for breast cancer: results from the Korean National Cancer Screening Survey, 2009-2021
Yejin Ha, Xuan Quy Luu, Woorim Kim, Jae Kwan Jun, Mina Suh, Kui Son Choi
Epidemiology and Health.2025; 47: e2025031. CrossRef - Under-recognized risk factors and low perceived breast cancer risk among rural women in South-central China: A multisite cross-sectional study
Yimeng Li, Qinyuan Huang, Mengdi Li, Yao Chen, Jyu-lin Chen, Dabao Xu, Man Ping Wang, Jia Guo
Asia-Pacific Journal of Oncology Nursing.2025; 12: 100797. CrossRef - Sex Disparity in Cancer and Non-cancer Mortality among Korean Cancer Survivors
Ansun Jeong, Soyeoun Kim, Somin Jeon, Boyoung Park
Journal of Cancer Prevention.2025; 30(4): 196. CrossRef - The Effect of Nationwide Organized Cancer Screening Programs on Gastric Cancer Mortality: A Synthetic Control Study
Dianqin Sun, Duco T. Mülder, Yige Li, Daan Nieboer, Jin Young Park, Mina Suh, Chisato Hamashima, Weiran Han, James F. O’Mahony, Iris Lansdorp-Vogelaar
Gastroenterology.2024; 166(3): 503. CrossRef - Population‐based evaluation of disparities in stomach cancer by nativity among Asian and Hispanic populations in California, 2011–2015
Eunjung Lee, Kai‐Ya Tsai, Juanjuan Zhang, Amie E. Hwang, Dennis Deapen, Jennifer J. Koh, Eric S. Kawaguchi, James Buxbaum, Sang Hoon Ahn, Lihua Liu
Cancer.2024; 130(7): 1092. CrossRef - Socio-economic factors and medical conditions affecting regular stomach cancer screening in Korea: a retrospective longitudinal study using national public health data for 11 years
J.-Y. Kim, J.Y. Hong, S.M. Kim, K.H. Ryu, D.S. Kim, S.H. Lee, J.H. Na, H.H. Cho, J. Yu, J. Lee
Public Health.2024; 227: 70. CrossRef - Relationship between menopausal hormone therapy and breast cancer: A nationwide population‐based cohort study
Jin‐Sung Yuk
International Journal of Gynecology & Obstetrics.2024; 166(2): 735. CrossRef - Risk of Subsequent Primary Cancers Among Adult-Onset 5-Year Cancer Survivors in South Korea: Retrospective Cohort Study
Yoon Young Choi, Myeongjee Lee, Eun Hwa Kim, Jae Eun Lee, Inkyung Jung, Jae-Ho Cheong
JMIR Public Health and Surveillance.2024; 10: e48380. CrossRef - Association between low-dose aspirin and the risk of gastric cancer and adenoma according to a family history of gastric cancer
Yoon Suk Jung, Mai Thi Xuan Tran, Boyoung Park, Chang Mo Moon
Digestive and Liver Disease.2024; 56(9): 1614. CrossRef - Temporal Trend in Uptake of the National General Health Checkups and Cancer Screening Program among Korean Women with Breast Cancer
Thi Xuan Mai Tran, Soyeoun Kim, Chihwan Cha, Boyoung Park
Cancer Research and Treatment.2024; 56(2): 522. CrossRef - Association between Gastric Cancer and Osteoporosis: A Longitudinal Follow-Up Study Using a National Health Sample Cohort
Kyeong Min Han, Mi Jung Kwon, Joo-Hee Kim, Ji Hee Kim, Woo Jin Bang, Hyo Geun Choi, Dae Myoung Yoo, Na-Eun Lee, Nan Young Kim, Ho Suk Kang
Cancers.2024; 16(13): 2291. CrossRef - Trends in breast density and other risk factors for breast cancer and associations with trends in the incidence of breast cancer in Korean women
Soyeoun Kim, Thi Xuan Mai Tran, Boyoung Park
Maturitas.2024; 189: 108070. CrossRef - National Statistics of Endoscopic Submucosal Dissection for Early Gastric Cancer in Korea
Sang Hoon Lee, Hyunseok Cho, Myoung-Nam Lim, Seung-Joo Nam
Journal of Gastric Cancer.2024; 24(4): 464. CrossRef - Public awareness of gastric cancer risk factors and screening behaviours in Shijiazhuang, China: A community-based survey
Qian Wang, Xiao-Ci He, Lian-Xia Geng, Shu-Lin Jiang, Chuan-Jie Yang, Kai-Yue Xu, Shu-Fang Shen, Wen-Wen Cao, Wei Qi, Shu-Ping Zhao, Pengpeng Ye
PLOS ONE.2024; 19(10): e0311491. CrossRef - Pattern Anlysis of Risk-Reducing Strategies in Unaffected Korean BRCA1/2 Mutation Carriers
Dabin Kim, Jai Min Ryu, Sang-Ah Han, Zisun Kim, Sung-Won Kim
Current Oncology.2024; 31(11): 6767. CrossRef - Effectiveness of the Korean National Cancer Screening Program in Reducing Colorectal Cancer Mortality
Hyeon Ji Lee, Kyeongmin Lee, Byung Chang Kim, Jae Kwan Jun, Kui Son Choi, Mina Suh
Cancers.2024; 16(24): 4278. CrossRef - The Significant Predictors for Breast, Cervical, Colorectal, or Oral Cancer Screening Intention and Behavior in Taiwan
Hsiu-Chen Huang, Pei-Chi Chang, Sin-Fong Li, Cing-Ya Wang, Wan-Ting Huang, Wei Chen, Sheng-Yu Fan
Cancer Nursing.2023; 46(4): E261. CrossRef - Increasing disparities in the proportions of active treatment and 5-year overall survival over time by age groups among older patients with gastric cancer in Korea
Hyun-Soo Zhang, Dong-Woo Choi, Han Sang Kim, Hye Jung Kang, Hoyol Jhang, Wonjeong Jeong, Chung Mo Nam, Sohee Park
Frontiers in Public Health.2023;[Epub] CrossRef - Changing trends in the incidence and spectrum of cancers between 1990 and 2021 among HIV-infected patients in Busan, Korea
Soon Ok Lee, Jeong Eun Lee, Yong Ki Sim, Shinwon Lee, Woo Seog Ko, Jinmi Kim, Jin Suk Kang, Hyunjin Son, Sun Hee Lee
Journal of Infection and Chemotherapy.2023; 29(6): 571. CrossRef - Positive faecal immunochemical test predicts the onset of inflammatory bowel disease: A nationwide, propensity score-matched study
Eunyoung Lee, Gil Ho Lee, Bumhee Park, Sung Soo Ahn, Choong-Kyun Noh
Frontiers in Immunology.2023;[Epub] CrossRef - Local Recurrence after Endoscopic Submucosal Dissection of Early Gastric Cancer
Dae-Gon Ryu, Su-Jin Kim, Cheol-Woong Choi, Su-Bum Park, Hyeong-Seok Nam, Si-Hak Lee, Sun-Hwi Hwang
Journal of Clinical Medicine.2023; 12(5): 2018. CrossRef - Association of Breast Cancer Family History With Breast Density Over Time in Korean Women
Thi Xuan Mai Tran, Yoosoo Chang, Soyeoun Kim, Huiyeon Song, Seungho Ryu, Boyoung Park
JAMA Network Open.2023; 6(3): e232420. CrossRef - Risk of upper gastrointestinal cancer and death in persons with negative screening results: results from the National Cancer Screening Program in South Korea
Xuan Quy Luu, Kyeongmin Lee, Jae Kwan Jun, Mina Suh, Kyu-Won Jung, Il Ju Choi, Kui Son Choi
Gastric Cancer.2023; 26(4): 580. CrossRef - Changes in cervical dysplasia, carcinoma in situ, and cervical cancer after expanding the National Cancer Screening Program to younger women in Korea
Woorim Kim, Sungyoun Chun, Sang Ah Lee
International Journal for Quality in Health Care.2023;[Epub] CrossRef - Elevated risk of cervical cancer in elderly women with incident ulcerative colitis in South Korea
Jihoon Kim, Halim Jo, Min Chul Ha, Hyunil Kim, Jung Kuk Lee, Jae Hun Han, San-Hui Lee, Dae Ryong Kang, Su Young Kim, Hyun-Soo Kim, Hee Man Kim
Scientific Reports.2023;[Epub] CrossRef - Mutual association between family history of gastric and colorectal cancer and risk of gastric and colorectal cancer
Yoon Suk Jung, Mai Thi Xuan Tran, Boyoung Park, Chang Mo Moon
Journal of Gastroenterology and Hepatology.2023; 38(10): 1787. CrossRef - Overview of the National Cancer Screening Program for Colorectal Cancer in Korea over 14 Years (2004-2017)
Bomi Park, Eun Young Her, Kyeongmin Lee, Fatima Nari, Jae Kwan Jun, Kui Son Choi, Mina Suh
Cancer Research and Treatment.2023; 55(3): 910. CrossRef - Impact of health disparities on national breast cancer screening participation rates in South Korea
Fatima Nari, Juwon Park, Nayeon Kim, Dong Jin Kim, Jae Kwan Jun, Kui Son Choi, Mina Suh
Scientific Reports.2023;[Epub] CrossRef - Socioeconomic inequality in organized and opportunistic screening for gastric cancer: results from the Korean National Cancer Screening Survey 2009–2022
Xuan Quy Luu, Kyeongmin Lee, Jae Kwan Jun, Mina Suh, Kui Son Choi
Frontiers in Public Health.2023;[Epub] CrossRef - The impact of stomach cancer mortality on life expectancy at birth: a decomposition analysis in east Asian countries from 1990 to 2019
Chunyong Chen, Leiwen Jiang, Siying Lyu, Guillaume Marois
China Population and Development Studies.2023; 7(4): 325. CrossRef - Parental intention to vaccinate daughters with the human papillomavirus vaccine in Korea: a nationwide cross-sectional survey
Yejin Ha, Kyeongmin Lee, Bomi Park, Mina Suh, Jae Kwan Jun, Kui Son Choi
Epidemiology and Health.2023; 45: e2023076. CrossRef - Socioeconomic inequality in organized and opportunistic screening for colorectal cancer: results from the Korean National Cancer Screening Survey, 2009-2021
Xuan Quy Luu, Kyeongmin Lee, Jae Kwan Jun, Mina Suh, Kui Son Choi
Epidemiology and Health.2023; 45: e2023086. CrossRef - Changes in weight and waist circumference during menopausal transition and postmenopausal breast cancer risk
Boyoung Park
International Journal of Cancer.2022; 150(9): 1431. CrossRef - Trends in cervical cancer screening rates among Korean women: results of the Korean National Cancer Screening Survey, 2005–2020
Hye Young Shin, Yun Yeong Lee, Soo Yeon Song, Bomi Park, Mina Suh, Kui Son Choi, Jae Kwan Jun
Journal of Gynecologic Oncology.2022;[Epub] CrossRef - Impact of preceding noncurative endoscopic submucosal dissection on patients with early gastric cancer who undergo subsequent surgery: a meta-analysis
Jian Jiao, Han Li, Liang Shang, Huicheng Ren, Chunshui Ye, Ronghua Zhang, Kun Xiao, Kangdi Dong, Jin Liu, Leping Li
Expert Review of Gastroenterology & Hepatology.2022; 16(4): 373. CrossRef - Relationship between histological mixed-type early gastric cancer and lymph node metastasis: A systematic review and meta-analysis
Shufan Yang, Xin Gu, Rui Tao, Jiahui Huo, Zhen Hu, Fei Sun, Jinbin Ni, Xiaoyun Wang, Girijesh Kumar Patel
PLOS ONE.2022; 17(4): e0266952. CrossRef - Mammographic breast density, body mass index and risk of breast cancer in Korean women aged 75 years and older
Thi Xuan Mai Tran, Soyeoun Kim, Huiyeon Song, Boyoung Park
International Journal of Cancer.2022; 151(6): 869. CrossRef - Current status of the gastric cancer screening program in Korea
Young-Il Kim, Il Ju Choi
Journal of the Korean Medical Association.2022; 65(5): 250. CrossRef - Nationwide population-based incidence of cancer among patients with HIV/AIDS in South Korea
Soon Ok Lee, Jeong Eun Lee, Shinwon Lee, Sun Hee Lee, Jin Suk Kang, Hyunjin Son, Hyungi Lee, Jinmi Kim
Scientific Reports.2022;[Epub] CrossRef - Impact of COVID-19 on cancer screening in South Korea
Kyeonmin Lee, Yun Yeong Lee, Mina Suh, Jae Kwan Jun, Bomi Park, Yeol Kim, Kui Son Choi
Scientific Reports.2022;[Epub] CrossRef - Current Evidence for a Paradigm Shift in Gastric Cancer Prevention From Endoscopic Screening toHelicobacter pyloriEradication in Korea
Young-Il Kim, Il Ju Choi
Journal of Gastric Cancer.2022; 22(3): 169. CrossRef - Epidemiology of Gastric Cancer in Korea: Trends in Incidence and Survival Based on Korea Central Cancer Registry Data (1999–2019)
Sin Hye Park, Mee Joo Kang, E Hwa Yun, Kyu-Won Jung
Journal of Gastric Cancer.2022; 22(3): 160. CrossRef - Association Between Family History of Gastric Cancer and the Risk of Gastric Cancer and Adenoma: A Nationwide Population-Based Study
Yoon Suk Jung, Mai Thi Xuan Tran, Boyoung Park, Chang Mo Moon
American Journal of Gastroenterology.2022; 117(8): 1255. CrossRef - Third Asia-Pacific consensus recommendations on colorectal cancer screening and postpolypectomy surveillance
Joseph J Y Sung, Han-Mo Chiu, David Lieberman, Ernst J Kuipers, Matthew D Rutter, Finlay Macrae, Khay-Guan Yeoh, Tiing Leong Ang, Vui Heng Chong, Sneha John, Jingnan Li, Kaichun Wu, Simon S M Ng, Govind K Makharia, Murdani Abdullah, Nozomu Kobayashi, Masa
Gut.2022; 71(11): 2152. CrossRef - Family history of breast cancer, mammographic breast density and breast cancer risk: Findings from a cohort study of Korean women
Thi Xuan Mai Tran, Soyeoun Kim, Huiyeon Song, Boyoung Park
The Breast.2022; 65: 180. CrossRef - Longitudinal Changes in Smoking Habits in Women and Subsequent Risk of Cancer
Thi Xuan Mai Tran, Soyeoun Kim, Huiyeon Song, Boyoung Park
American Journal of Preventive Medicine.2022; 63(6): 894. CrossRef - The Prediction of Survival Outcome and Prognosis Factor in Association with Comorbidity Status in Patients with Colorectal Cancer: A Research-Based Study
Hafeez Afolabi, Salzihan Md Salleh, Zaidi Zakaria, Ewe Seng Ch’ng, Siti Norasikin Mohd Nafi, Ahmad Aizat Bin Abdul Aziz, Sameer Badri Al-Mhanna, Yusuf Wada, Abdulwali Sabo Abdulrahman
Healthcare.2022; 10(9): 1693. CrossRef - Association between A Family History of Colorectal Cancer and the Risk of Colorectal Cancer: A Nationwide Population-Based Study
Yoon Suk Jung, Huiyeon Song, Mai Thi Xuan Tran, Boyoung Park, Chang Mo Moon
Journal of Personalized Medicine.2022; 12(10): 1566. CrossRef - Income Disparity in Breast Cancer Incidence and Stage at Presentation: A National Population Study of South Korea
Seung-Ah Choe, Minji Roh, Hye Ri Kim, Soohyeon Lee, Myung Ki, Domyung Paek, Mia Son
Journal of Breast Cancer.2022; 25(5): 415. CrossRef - Analysis of HR-HPV Infection Concordance Rates in Cervical and Urine Specimens; Proposal of Additional Cervical Screening Process for Women Who Refuse Invasive Cervical Sampling
Dong Hyeok Kim, Hyunwoo Jin, Kyung Eun Lee
Journal of Personalized Medicine.2022; 12(12): 1949. CrossRef - Association of Late Marriage and Low Childbirth with Cervical Cancer Screening among Korean Women: Results from a Nationwide Survey
Hye Young Shin, Bomi Park, Mina Suh, Kui Son Choi, Jae Kwan Jun
Cancers.2022; 14(2): 327. CrossRef - Presentation of benefits and harms in cancer screening guidelines for Koreans: a systematic review protocol
Mi Ah Han, Jae Hung Jung, Eu Chang Hwang
BMJ Open.2022; 12(12): e065924. CrossRef - Effect of Pap smears on the long-term survival of cervical cancer patients: a nationwide population-based cohort study in Korea
Xuan Quy Luu, Kyeongmin Lee, Jae Kwan Jun, Mina Suh, kyu-won Jung, Myong Cheol Lim, Kui Son Choi
Epidemiology and Health.2022; 44: e2022072. CrossRef - Awareness of and practice toward cancer prevention recommendations: results of the Korean National Cancer Prevention Awareness and Practice Survey in 2021
Jin-Kyoung Oh, Eunjung Park, Byungmi Kim, Yoon-Jung Choi, E Hwa Yun, Min Kyung Lim, Jeong-Soo Im, Eun Young Park
Epidemiology and Health.2022; 44: e2022068. CrossRef - Effect of mammography screening on the long-term survival of breast cancer patients: results from the National Cancer Screening Program in Korea
Xuan Quy Luu, Kyeongmin Lee, Jae Kwan Jun, Mina Suh, Kyu-Won Jung, Kui Son Choi
Epidemiology and Health.2022; 44: e2022094. CrossRef - Changes in cancer screening before and during COVID‐19: findings from the Korean National Cancer Screening Survey 2019 and 2020
Thao Thi Kim Trinh, Yun Yeong Lee, Mina Suh, Jae Kwan Jun, Kui Son Choi
Epidemiology and Health.2022; 44: e2022051. CrossRef - Trends in breast cancer screening rates among Korean women: results from the Korean National Cancer Screening Survey, 2005-2020
Soo Yeon Song, Yun Yeong Lee, Hye Young Shin, Bomi Park, Mina Suh, Kui Son Choi, Jae Kwan Jun
Epidemiology and Health.2022; 44: e2022111. CrossRef - The impact of COVID-19 on screening for colorectal, gastric, breast, and cervical cancer in Korea
Hyeree Park, Seung Hee Seo, Jong Heon Park, Shin Hye Yoo, Bhumsuk Keam, Aesun Shin
Epidemiology and Health.2022; 44: e2022053. CrossRef - A nationwide survey on the effectiveness of training on endoscope reprocessing within the national cancer screening program in Korea
Hye Young Shin, Da Hun Jang, Jae Kwan Jun
American Journal of Infection Control.2021; 49(8): 1031. CrossRef - Current indications for endoscopic submucosal dissection of early gastric cancer
Zhi Zheng, Jie Yin, Xiao-Ye Liu, Xiao-Sheng Yan, Rui Xu, Meng-Yi Li, Jun Cai, Guang-Yong Chen, Jun Zhang, Zhong-Tao Zhang
World Journal of Gastrointestinal Oncology.2021; 13(6): 560. CrossRef - Effectiveness of the Korean National Cancer Screening Program in reducing breast cancer mortality
Eunji Choi, Jae Kwan Jun, Mina Suh, Kyu-Won Jung, Boyoung Park, Kyeongmin Lee, So-Youn Jung, Eun Sook Lee, Kui Son Choi
npj Breast Cancer.2021;[Epub] CrossRef - International comparison of trends in cancer mortality: Japan has fallen behind in screening-related cancers
Kota Katanoda, Yuri Ito, Tomotaka Sobue
Japanese Journal of Clinical Oncology.2021; 51(11): 1680. CrossRef - Korean Gastric Cancer Association-Led Nationwide Survey on Surgically Treated Gastric Cancers in 2019
Journal of Gastric Cancer.2021; 21(3): 221. CrossRef - Barriers and strategies for cervical cancer screening: What do female university students know and want?
Hye Young Shin, Soo Yeon Song, Jae Kwan Jun, Ka Young Kim, Purum Kang, Nülüfer Erbil
PLOS ONE.2021; 16(10): e0257529. CrossRef - The classification capability of the Asia Pacific Colorectal Screening score in Korea: an analysis of the Cancer Screenee Cohort
Xuan Quy Luu, Kyeongmin Lee, Jeongseon Kim, Dae Kyung Sohn, Aesun Shin, Kui Son Choi
Epidemiology and Health.2021; 43: e2021069. CrossRef
- Information Landscape on Cervical Cancer: An Analysis of News and Online Platform Data in the Republic of Korea
- 17,464 View
- 349 Download
- 85 Web of Science
- 80 Crossref
- Preclinical Efficacy Testing for Stomach and Liver Cancers
- Jun Won Park, Nam Suk Baek, Seok Cheol Lee, Su Jin Oh, Seok Hoon Jang, In Hoo Kim, Dae Yong Kim, Hark Kyun Kim
- Cancer Res Treat. 2014;46(2):186-193. Published online April 15, 2014
- DOI: https://doi.org/10.4143/crt.2014.46.2.186
-
Abstract
PDFPubReaderePub
Purpose Hollow fiber assays offer an early
in vivo method of anticancer drug screening. The assays have been optimized for human cancers originating from the lung, breast, colon, ovary, and brain, but not from the stomach and liver. The current study focused on optimization of hollow fiber assays for gastric and hepatocellular carcinoma cell lines.Materials and Methods Gastric (SNU-16, SNU-484, SNU-668) and hepatocellular (HepG2, SK-Hep-1, Hep3B) carcinoma cell lines in hollow fibers were transplanted subcutaneously and intraperitoneally into mice, which were subsequently treated with a standard anticancer agent, paclitaxel. The hollow fiber activity of paclitaxel in each cell line was compared with the xenograft activity.
Results Using optimized inoculation densities and schedules, treatment with paclitaxel was effective in gastric carcinoma cell lines, SNU-16 and SNU-484, but not in SNU-668. In the hollow fiber assays, paclitaxel was effective in hepatocellular carcinoma cell lines, HepG2 and SK-Hep-1, but not in Hep3B. Consistent with the results of the hollow fiber assay, SNU-16 and SNU-484, but not SNU-668, showed tumor regression, and HepG2 and SK-Hep-1, but not Hep3B, showed effective tumor responses following treatment with paclitaxel in xenograft models. When EW7197, a novel compound, and flavopiridol were tested in SNU-16 cells under optimized conditions, the hollow fiber activity showed good correlation with the xenograft activity of each compound.
Conclusion Our protocols may be useful for screening candidate small molecules that may exhibit activity against stomach and liver cancers, both of which are common in Korea.
-
Citations
Citations to this article as recorded by- Synopsis on the Linkage of Alzheimer's and Parkinson's Disease with Chronic Diseases
Nasimudeen R. Jabir, Chelapram K. Firoz, Saleh S. Baeesa, Ghulam Md Ashraf, Suhail Akhtar, Warda Kamal, Mohammad A. Kamal, Shams Tabrez
CNS Neuroscience & Therapeutics.2015; 21(1): 1. CrossRef - The Effect of Disintegrin–Metalloproteinase ADAM9 in Gastric Cancer Progression
Jeong Min Kim, Hei-Cheul Jeung, Sun Young Rha, Eun Jeong Yu, Tae Soo Kim, You Keun Shin, Xianglan Zhang, Kyu Hyun Park, Seung Woo Park, Hyun Cheol Chung, Garth Powis
Molecular Cancer Therapeutics.2014; 13(12): 3074. CrossRef
- Synopsis on the Linkage of Alzheimer's and Parkinson's Disease with Chronic Diseases
- 15,239 View
- 136 Download
- 3 Web of Science
- 2 Crossref
- Geographical Variation of Liver Cancer Mortality in Korea (1992-1998)
- Duk Hee Lee, Jin Ha Kim, Byung Hun Han, Sang Ook Lee, Hai Rim Shin, In Chul Jung
- Cancer Res Treat. 2001;33(5):420-426. Published online October 31, 2001
- DOI: https://doi.org/10.4143/crt.2001.33.5.420
-
Abstract
PDF
- PURPOSE
The death rate of liver cancer in Korea has been reported as one of the highest in the world. This study was conducted to investigate geographical variations of liver cancer mortality in Korea in order to obtain insight into possible environmental factors related to liver cancer.
MATERIALS AND METHODS
The sex-specific standardized mortality ratios (SMRs) of liver cancer were calculated for 168 basic administrative units in Korea based upon the vital statistics for the seven years 1992 to 1998, as well as the sex- and age-specific population of each area for 1995. The SMRs were classified into six categories and depicted on a map for each sex.
RESULTS
The southern provinces showed clearly higher mortality rates as compared to the rest of the country in both males and females. Looking at the maps in detail, there was a geographical variation even within the southern provinces. The areas around large rivers, some costal areas, and costal islands showed a high mortality rate. Even in the middle and northern provinces, the eastern costal areas showed relatively higher mortality rates as compared to inland areas. Conversely, some southern areas known for low levels of pollution showed relatively lower mortality rates.
CONCLUSION
This finding suggests a possible relationship between liver cancer and water-related foods from polluted rivers or seas. Further studies should be performed in order to clarify which factors cause this geographical variation. -
Citations
Citations to this article as recorded by- Regional Factors Affecting Liver Cancer Mortality Using GWR
Jin Hyun Son, Wooseok Ryu
Journal of Health Informatics and Statistics.2024; 49(4): 404. CrossRef - Prevalence and Related Factors of Clonorchiasis among Five Major Riverside Residents in South Korea
Chunmi Kim, Kyung Ja June, Shin Hyeong Cho, Kyung Soon Park, Hung Sa Lee, Ji Yeon Park
Journal of Korean Academy of Community Health Nursing.2016; 27(4): 346. CrossRef - The knowledge and attitudes towards hepatitis B among paramedic students
Bo-Ram Choi, Dong-Ok Kim, Gyung-Hun Min
The Korean Journal of Emergency Medical Services.2016; 20(3): 57. CrossRef - Viral Hepatitis and Liver Cancer in Korea: an Epidemiological Perspective
Yohwan Yeo, Jin Gwack, Seokin Kang, Boyeon Koo, Sun Jae Jung, Prakash Dhamala, Kwang-Pil Ko, Young-Khi Lim, Keun-Young Yoo
Asian Pacific Journal of Cancer Prevention.2013; 14(11): 6227. CrossRef - A Study on the Prevalence of Clonorchis Sinensis and the Effects of Educational Program among Residents in the Basin of the Youngsan River, Korea
Chunmi Kim, Aeyoung So, Kyung-Ja June, Hee Young Jung
Journal of Korean Academy of Community Health Nursing.2011; 22(1): 56. CrossRef - Hepatitis B and C virus prevalence in a rural area of South Korea: the role of acupuncture
H R Shin, J Y Kim, J I Kim, D H Lee, K Y Yoo, D S Lee, S Franceschi
British Journal of Cancer.2002; 87(3): 314. CrossRef
- Regional Factors Affecting Liver Cancer Mortality Using GWR
- 5,363 View
- 28 Download
- 6 Crossref
- Intrahepatic Recurrence after Transhepatic Arterial Chemoembolization in Hepatocellular Carcinoma
- Tae Yong Moon, Byung Soo Kim, Suck Hong Lee, Hak Jin Kim, Sung Yup Lim, Bong Sig Koo
- J Korean Cancer Assoc. 1995;27(6):924-929.
-
Abstract
PDF
- Purpose
We have investigated the annual frequency of recurrent intrahepatic tumors and the doubling time of regrowing tumors after transhepatic arterial chemoembolization (TAE) to know the proper time for subsequent TAE. Materials and Methods: Among cases in which a previous TAE was performed, 28 cases showed definite intrahepatic recurrence and 7 cases showed a regrowing tumor in the follow-up liver CT scan and/or hepatic angiography. Resnlts: The annual frequency of intrahepatic recurrence in the 28 tumors was 71.4% (20/28) within one year and 100% within 6 years. The mean doubling time of 7 regrowing tumors was 68.3 days. Conclusion: We concluded that periodically repeated TAE is needed for further treatment of the recurrent and regrowing tumors.
- 3,486 View
- 13 Download
- Dose-Response Relationship of Radiotherapy for Locally Advanced Hepatocellular Carcinoma
- Dae Yong Kim, Joon Hyoek Lee, Kwang Cheol Koh, Seung Woon Paik, Yong Chan Ahn, Seung Jae Huh, Inhwan J Yeo, Suk Won Park, Seung Hee Chang
- J Korean Cancer Assoc. 2000;32(5):918-924.
-
Abstract
PDF
- PURPOSE
Recently radiotherapy is applied alone or in conjunction with transcatheter arterial chemoembolizaion (TACE) or percutaneous ethanol injection therapy (PEIT) for locally advanced hepatocellular carcinoma (HCC). The purpose of this study was to evaluate dose-response relationship of radiotherapy for local control and toxicity in inoperable HCC.
MATERIALS AND METHODS
Twenty-eight patients who were not eligible for TACE and PEIT or had showed no response to these treatment were treated with a total dose of 40 Gy with 2 Gy per fraction or 30 Gy with 3 Gy per fraction (low dose group, 18 patients) or 45 Gy with 3 Gy per fraction (high dose group, 10 patients).
RESULTS
The median survival duration was 8 months and 1-year survival rate was 37%. The treatment results were as follows; partial response in 11% and 70% (p=0.001), stable disease in 56% and 30%, and progressive disease in 33% and 0% in low dose group and high dose group, respectively. The incidence of gastrointestinal (G-I) toxicity by the criteria of Southwest Oncology Group was as follows; grade 1 in 22% and 40%, grade 2 in 17% and 10%, respectively (p=0.56). There was no patient with severe G-I toxicity above grade 3. The incidence of G-I toxicity by site was as follows; grade 1 in 24% and 29%, and grade 2 in 0% and 57% in patients with right lobe and left lobe lesion, respectively (p=0.001).
CONCLUSION
This study indicates that there is clear dose-response relationship in local control. The G-I toxicity does not increase significantly with increment of radiation dose within the dose range tested in this study. And careful attention should be paid for G-I toxicity when the tumor is located in left lobe.
- 3,495 View
- 15 Download
- Radioresponse of Hepatdegrees Celluar Carcinoma Treatment of Lymph Node Metastasis
- Jong Hoon Kim, Eun Kyung Choi, Young Wha Chung, Young Sang Lee, Dong Jin Seo
- J Korean Cancer Assoc. 2000;32(3):571-577.
- 3,101 View
- 19 Download
First
Prev
