Cancer Research and Treatment

Original Articles

Hematologic malignancy

Assessment of Bone Marrow Involvement in Extranodal NK/T-Cell Lymphoma: Positron Emission Tomography versus Bone Marrow Biopsy, and the Significance of Minimal Involvement by EBV+ Cells (KROG 18-09): Tae Hoon Lee, Hyun Ju Kim, Jong Hoon Lee, Jeongshim Lee, Jin Hee Kim, Dongryul Oh, Keun-Yong Eom; Cancer Res Treat. 2024;56(2):688-696. Published online December 11, 2023; DOI: https://doi.org/10.4143/crt.2023.1049

Abstract PDF PubReader ePub: Purpose
This study aims to investigate the diagnostic significance of positron emission tomography/computed tomography (PET/CT) in assessing bone marrow (BM) involvement through a comparison of PET/CT findings with BM biopsy in extranodal natural killer/T-cell lymphoma.
Materials and Methods
The medical records of 193 patients were retrospectively reviewed. Patients were categorized as having early-stage (PET-ES) or advanced-stage (PET-AS) disease based on PET/CT results. The BM involvement was classified into three groups according to BM biopsy: gross BM involvement, minimal BM involvement (defined as the presence of a limited number of Epstein-Barr virus–positive cells in BM), and no involvement. Calculations of the accuracy of PET/CT in detecting BM involvement and analysis of the clinical outcomes (progression-free survival [PFS] and overall survival [OS]) according to the BM biopsy status were performed.
Results
PET/CT exhibited a sensitivity of 64.7% and a specificity of 96.0% in detecting gross BM involvement. For detecting any (both gross and minimal) BM involvement, the sensitivity was 30.4%, while the specificity was 99.0%. Only one patient (0.7%) demonstrated gross BM involvement among the PET-ES group. Survival outcomes of the PET-ES group with minimal BM involvement (3-year PFS, 55.6%; OS, 77.0%) were closer to those of the PET-ES group with no BM involvement (3-year PFS, 62.2%; OS, 80.6%) than to those of the PET-AS group (3-year PFS, 20.1%; OS, 29.9%).
Conclusion
PET/CT exhibits high specificity, but moderate and low sensitivity in detecting gross and minimal BM involvement, respectively. The clinical significance of minimal BM involvement for patients in the PET-ES group may be limited.

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Pediatric cancer

Outcome of Intensive Therapy for Children with Relapsed Acute Myeloid Leukemia: A Single Institution Korean Study: Jae Wook Lee, Jae Won Yoo, Seongkoo Kim, Pil-Sang Jang, Nack-Gyun Chung, Bin Cho; Cancer Res Treat. 2022;54(4):1230-1239. Published online December 17, 2021; DOI: https://doi.org/10.4143/crt.2021.1011

Abstract PDF Supplementary Material PubReader ePub

Purpose
Approximately 30%-40% of pediatric acute myeloid leukemia (AML) patients relapse. In this study, we analyzed the outcome and prognostic factors of relapsed AML patients who had previously received first-line therapy at our institution.
Materials and Methods
The study group consisted of 50 patients who had been diagnosed with AML from April 2009 to December 2018, and then showed first relapse. Thirty-two of the patients (64%) had previously received allogeneic hematopoietic stem cell transplantation (HSCT) in first complete remission (CR).
Results
Forty-five of the patients (90%) received intensive chemotherapy upon diagnosis of relapse, and 76% (34/45) of these patients achieved a second CR. Estimated 5-year overall survival for these 45 patients was 44.9%±7.6%. Time from diagnosis to relapse, extramedullary involvement (EMI) at diagnosis, core binding factor AML, and complex karyotype were significant prognostic factors; in multivariate study, both time from diagnosis to relapse and EMI at diagnosis proved significant. There was no difference in 5-year disease-free survival between patients previously treated with chemotherapy only and those who received HSCT in first CR (52.4%±14.9% vs. 52.6%±11.5%). Of the 19 patients who achieved second CR after previous allogeneic HSCT in first CR and subsequent relapse, 11 were treated with chemotherapy only, and seven survive disease-free.
Conclusion
Intensive therapy allowed for long-term survival in 40%-50% of patients, and 50% of patients who achieved second CR, regardless of prior treatment modalities in first CR. Intensive treatment may allow for salvage of a significant portion of patients with relapsed pediatric AML.

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Diagnosis and Treatment of Pediatric Acute Megakaryoblastic Leukemia with NUP98::KDM5A Rearrangement: Case Report
Hyemin Kang, Suejung Jo, Jae Won Yoo, Seongkoo Kim, Jae Wook Lee, Nack-Gyun Chung, Bin Cho, Chae Yeon Lee, Myungshin Kim
Clinical Pediatric Hematology-Oncology.2024; 31(2): 56. CrossRef

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Case Report

Seminal Vesicle Involvement by Carcinoma In Situ of the Bladder: Clonal Analysis Using Next-Generation Sequencing to Elucidate the Mechanism of Tumor Spread: Hyun Sik Park, Hyun Bin Shin, Myung-Shin Lee, Joo Heon Kim, Seon-Young Kim, Jinsung Park; Cancer Res Treat. 2020;52(4):1283-1287. Published online March 19, 2020; DOI: https://doi.org/10.4143/crt.2020.002

Abstract PDF Supplementary Material PubReader ePub: We present a rare case of urothelial carcinoma in situ (CIS), which invades the prostate and seminal vesicle (SV). A 70-year-old man underwent transurethral resection of bladder (TURB), and the pathologic examination revealed multiple CIS. Although the patient received intravesical bacillus Calmette-Guerin (BCG) therapy following TURB, recurrence of CIS was confirmed in the bladder and left distal ureter at 3 months following BCG. Radical cystectomy was performed due to BCG-refractory CIS. Microscopically, CIS was found throughout the mucosa of the bladder, left ureter, prostatic duct, and both SVs. Next-generation sequencing revealed significant differences in tumor clonality between bladder and SV CIS cells. Among 101 (bladder CIS) and 95 (SV CIS) somatic mutations, only two were shared, and only one gene (ARHGAP23) was common exon coding region gene. In conclusion, multicentric genetic changes, in line with the field-cancerization effect, may result in SV involvement by CIS of the bladder.

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Original Articles

Patient’s Cognitive Function and Attitudes towards Family Involvement in Cancer Treatment Decision Making: A Patient-Family Caregiver Dyadic Analysis: Dong Wook Shin, Juhee Cho, Debra L. Roter, So Young Kim, Jong Hyock Park, Hyung Kook Yang, Hyun Woo Lee, Sun-Seog Kweon, Yune Sik Kang, Keeho Park; Cancer Res Treat. 2018;50(3):681-690. Published online July 4, 2017; DOI: https://doi.org/10.4143/crt.2017.201

Abstract PDF PubReader ePub

Purpose
Older patient populations commonly have cognitive impairment, which might impact decisional capacity. We examined patients and family caregivers preferences for family involvement in treatment decision making assuming different level of cognitive impairment, and sought to explore the factors associated with the preferences and the degree to which patients and family members agree on preferences.
Materials and Methods
A total of 358 elderly cancer patient and caregiver dyads were recruited from the 11 cancer centers in Korea andwere asked to express their preferences forfamily involvement in treatment decision making using hypothetical scenarios with three different levels of cognitive status (intact, mild impairment, and severe impairment).
Results
Both patients and family caregivers preferred greater family dominance in treatment decision makingwith the increasing the level of cognitive impairment (39.7%, 60.9%, and 86.6% for patients and 45.0%, 66.2%, and 89.7% for caregivers in each scenarios). Patient and family caregiver concordance in decisional control preference was small for all three scenarios (weighted κ=0.32, κ=0.26, and κ=0.36, respectively). Higher patient education was associated with preference for patient dominance in treatment decision in conditions of both mild and severe cognitive impairment. The association of higher patient education and patient-caregiver preference concordance was positive with intact cognition, while it was negative with severe cognitive impairment.
Conclusion
Decision control preferences were affected by hypothesized cognitive status of the patients. Findings from our study would be helpful to develop effective strategy for optimizing family involvement in cancer treatment decision in the context of deteriorating cognitive function of the patients.

Citations

Citations to this article as recorded by

Comorbid Dementia and Cancer Therapy Decision-Making: A Scoping Review
Sean N. Halpin, Gabriel Alain, Aaron Seaman, Erin E. Stevens, Hui Zhao, Mackenzie E. Fowler, Qiuyang Zhang, Tamara Cadet, Minzhi Ye, Jessica L. Krok-Schoen
Journal of Applied Gerontology.2024; 43(8): 1132. CrossRef
Assessing the association between quantity and quality of family caregiver participation in decision-making clinical encounters on patient activation in the metastatic breast cancer setting
Nicole L. Henderson, Tanvi Padalkar, Garrett Bourne, Emma K. Hendrix, Courtney P. Williams, J. Nicholas Odom, Kristen Triebel, Gabrielle B. Rocque
Supportive Care in Cancer.2024;[Epub] CrossRef
Fatalism and metaphor in Confucianism: A qualitative study of barriers to genetic testing among first‐degree relatives of hereditary cancer patients from China
Chaonan Jiang, Li Liu, Ye Wang, Liangzheng Wu, Wenxia Zhang, Xiaodan Wu
Psycho-Oncology.2023; 32(2): 275. CrossRef
The Role of Nurse on the Treatment Decision Support for Older People with Cancer: A Systematic Review
Hiroko Komatsu, Yasuhiro Komatsu
Healthcare.2023; 11(4): 546. CrossRef
A prospective cohort study of decision‐making role preferences of patients with advanced cancer and their family caregivers
Semra Ozdemir, Sean Ng, Isha Chaudhry, Chetna Malhotra, Eric Andrew Finkelstein
Cancer.2023; 129(9): 1443. CrossRef
Cancer literacy among Jordanian colorectal cancer survivors and informal carers: Qualitative explorations
Samar J. Melhem, Shereen Nabhani-Gebara, Reem Kayyali
Frontiers in Public Health.2023;[Epub] CrossRef
Preferred and actual involvement of caregivers in oncologic treatment decision-making: A systematic review
Laura M.L. Tielemans, Kirsten D. van Heugten, Marije E. Hamaker, Inez C. van Walree
Journal of Geriatric Oncology.2023; 14(6): 101525. CrossRef
Factors Affecting Patient and Caregiver Preferences for Treatment of Myeloma and Indolent Lymphoma
Chia Jie Tan, Melinda Si Yun Tan, Chandramouli Nagarajan, Wee Joo Chng, Yen-Lin Chee, Melissa Ooi, Lawrence Cheng Kiat Ng, Yunxin Chen, Joanne Su Yin Yoong, Xin Yi Wong, Wei-Ying Jen
JCO Oncology Practice.2023; 19(12): 1168. CrossRef
The Association Between Mild Cognitive Impairment Diagnosis and Patient Treatment Preferences: a Survey of Older Adults
Deborah A. Levine, Andrzej T. Galecki, Brenda L. Plassman, Angela Fagerlin, Lauren P. Wallner, Kenneth M. Langa, Rachael T. Whitney, Brahmajee K. Nallamothu, Lewis B. Morgenstern, Bailey K. Reale, Emilie M. Blair, Bruno Giordani, Kathleen Anne Welsh-Bohme
Journal of General Internal Medicine.2022; 37(8): 1925. CrossRef
Patient activation and treatment decision-making in the context of cancer: examining the contribution of informal caregivers’ involvement
Chiara Acquati, Judith H. Hibbard, Ellen Miller-Sonet, Anao Zhang, Elena Ionescu
Journal of Cancer Survivorship.2022; 16(5): 929. CrossRef
Factors influencing family involvement in treatment decision-making for older patients with cancer: A scoping review
Bea L. Dijkman, Marie Louise Luttik, Hanneke Van der Wal-Huisman, Wolter Paans, Barbara L. van Leeuwen
Journal of Geriatric Oncology.2022; 13(4): 391. CrossRef
The role of caregivers in the clinical pathway of patients newly diagnosed with breast and prostate cancer: A study protocol
Clizia Cincidda, Serena Oliveri, Virginia Sanchini, Gabriella Pravettoni
Frontiers in Psychology.2022;[Epub] CrossRef
Treatment decision-making for older adults with cancer: A qualitative study
Ni Gong, Qianqian Du, Hongyu Lou, Yiheng Zhang, Hengying Fang, Xueying Zhang, Xiaoyu Wu, Ya Meng, Meifen Zhang
Nursing Ethics.2021; 28(2): 242. CrossRef
Family Caregiving Situations and Engagement in Advance Care Planning
Kyeongmo Kim, Michin Hong, Thomas Buckley
Journal of Palliative Medicine.2020; 23(1): 125. CrossRef
What We Talk about When We Talk about Caregiving: The Distribution of Roles in Cancer Patient Caregiving in a Family-Oriented Culture
Ansuk Jeong, Dongwook Shin, Jong Hyock Park, Keeho Park
Cancer Research and Treatment.2019; 51(1): 141. CrossRef
Experience with age discrimination and attitudes toward ageism in older patients with cancer and their caregivers: A nationwide Korean survey
Dong Wook Shin, Keeho Park, Ansuk Jeong, Hyung Kook Yang, So Young Kim, Mihee Cho, Jong Hyock Park
Journal of Geriatric Oncology.2019; 10(3): 459. CrossRef
How family caregivers of persons with advanced cancer assist with upstream healthcare decision-making: A qualitative study
J. Nicholas Dionne-Odom, Deborah Ejem, Rachel Wells, Amber E. Barnato, Richard A. Taylor, Gabrielle B. Rocque, Yasemin E. Turkman, Matthew Kenny, Nataliya V. Ivankova, Marie A. Bakitas, Michelle Y. Martin, Mojtaba Vaismoradi
PLOS ONE.2019; 14(3): e0212967. CrossRef

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Predictors of Distant Metastasis after Radical Surgery Followed by Postoperative Radiotherapy with or without Chemotherapy for Oropharyngeal Cancer: Mi Joo Chung, Yeon Sil Kim, Ji Yoon Kim, Yun Hee Lee, Ji Hyun Jang, Jin Hyoung Kang, Ie Ryung Yoo, Youn Soo Lee; Cancer Res Treat. 2016;48(4):1167-1176. Published online March 3, 2016; DOI: https://doi.org/10.4143/crt.2015.379

Abstract PDF PubReader ePub

Purpose
We investigated the prognostic factors for distant metastasis (DM) in patients with locally advanced oropharyngeal cancer (OPC) treated with surgery and adjuvant radiotherapy with or without concurrent chemotherapy.
Materials and Methods
Eighty-five patients treated between January 1995 and August 2014 were evaluated retrospectively. Data regarding the pathological tumour and nodal status, human papillomavirus (HPV) status, treatment characteristics, and pretreatment maximum standardized uptake value (SUVmax) of 18-fluoro-2-deoxyglucose positron emission tomography–computed tomography scan (¹⁸F-FDG PET-CT) were evaluated, and their influence on DM and survival outcomes were analyzed.
Results
Median follow-up period was 48.0 months. Recurrence was observed in 20 patients, including locoregional recurrence and DM. DM was observed in 13 patients. A multivariate analysis confirmed that the presence of lymphovascular invasion (p=0.031), lower neck lymph node (LN) involvement (p=0.006), SUVmax ≥ 9.7 (p=0.014), and tumour size ≥ 3 cm (p=0.037) significantly affected DM. HPV status was not associated with DM. Perineural invasion (p=0.048), lower neck LNinvolvement (p=0.008), SUVmax ≥ 9.7 (p=0.019), and tumour size ≥ 3 cm (p=0.033) were also significant factors for the DM-free survival rate.
Conclusion
Lower neck LN involvement, high SUVmax in pretreatment ¹⁸F-FDG PET-CT, and large tumour size were predictive factors for DM in patients of OPC.

Citations

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An open, multicenter, exploratory study of apatinib mesylate maintenance therapy for recurrent/metastatic head and neck squamous cell carcinoma (ChiCTR1800019375)
Jinlong Wei, Jing Su, Jianfeng Wang, Xiaojing Jia, Qin Zhao, Weiyan Shi, Huanhuan Wang, Zhuangzhuang Zheng, Xin Jiang
Head & Neck.2024; 46(4): 915. CrossRef
The Prognostic Role of Perineural Invasion for Survival in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis
Zhuo-Ying Tao, Guang Chu, Yu-Xiong Su
Cancers.2024; 16(14): 2514. CrossRef
Management of Recurrent HPV-Positive Oropharyngeal Squamous Cell Carcinoma: a Contemporary Review
Sam Dowthwaite, James Jackson, Marcin Dzienis, Eric Khoo, Mathew Cronin, Emily Guazzo
Current Oncology Reports.2023; 25(5): 501. CrossRef
A Mn-doped calcium phosphate nanoparticle-based multifunctional nanocarrier for targeted drug delivery and cellular MR imaging
Chaohui Zhou, Shenglei Hou, Chusen Huang, Nengqin Jia
Journal of Nanoparticle Research.2022;[Epub] CrossRef
Importance of lymph node ratio in HPV-related oropharyngeal cancer patients treated with surgery and adjuvant treatment
Kyu Hye Choi, Jin Ho Song, Ji Hyun Hong, Youn Soo Lee, Jin Hyoung Kang, Dong-Il Sun, Min-Sik Kim, Yeon-Sil Kim, Yifei Wang
PLOS ONE.2022; 17(8): e0273059. CrossRef
18F-FDG PET/CT–Based Prognostic Survival Model After Surgery for Head and Neck Cancer
Gwenaelle Creff, Franck Jegoux, Xavier Palard, Adrien Depeursinge, Ronan Abgral, Remi Marianowski, Jean-Christophe Leclere, Thomas Eugene, Olivier Malard, Renaud De Crevoisier, Anne Devillers, Joel Castelli
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Risk stratification of postoperative recurrence in hypopharyngeal squamous-cell carcinoma patients with nodal metastasis
Hanqing Lin, Tian Wang, Yu Heng, Xiaoke Zhu, Liang Zhou, Ming Zhang, Yong Shi, Pengyu Cao, Lei Tao
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A two-fold interpenetration pillar-layered metal-organic frameworks based on BODIPY for chemo-photodynamic therapy
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Dyes and Pigments.2021; 188: 109174. CrossRef
Current Updates on Cancer-Causing Types of Human Papillomaviruses (HPVs) in East, Southeast, and South Asia
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Sequentially self-assembled polysaccharide-based nanocomplexes for combined chemotherapy and photodynamic therapy of breast cancer
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Carbohydrate Polymers.2019; 203: 203. CrossRef
Self-assembly of photosensitive and chemotherapeutic drugs for combined photodynamic-chemo cancer therapy with real-time tracing property
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Colloids and Surfaces A: Physicochemical and Engineering Aspects.2019; 574: 44. CrossRef
Patterns of recurrence in oral tongue cancer with perineural invasion
Jennifer R. Cracchiolo, Bin Xu, Jocelyn C. Migliacci, Nora Katabi, David G. Pfister, Nancy Y. Lee, Snehal G. Patel, Ronald A. Ghossein, Richard J. Wong
Head & Neck.2018; 40(6): 1287. CrossRef
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ACS Applied Materials & Interfaces.2017; 9(15): 13016. CrossRef

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Case Report

A Rare Presentation of Follicular Lymphoma: Cerebellar Involvement, Successfully Treated with a Combination of Radiotherapy and Chemotherapy: Nuri Karadurmus, Selmin Ataergin, Gokhan Erdem, Mustafa Cakar, Ozdes Emer, Sukru Ozaydin, Mustafa Ozturk, Mukerrem Safali, Fikret Arpaci; Cancer Res Treat. 2013;45(3):234-238. Published online September 30, 2013; DOI: https://doi.org/10.4143/crt.2013.45.3.234

Abstract PDF PubReader ePub

The central nervous system (CNS) is an important area of involvement for both high-grade, aggressive primary and secondary lymphomas. Although follicular lymphoma represents a low-grade histology, it may rarely present with CNS involvement. Here, we describe a patient diagnosed with follicular lymphoma who was presented with cerebellar involvement.

Citations

Citations to this article as recorded by

Follicular lymphoma with secondary central nervous system relapse: a case report and literature review
Yuri Tsuboi, Misayo Shimizu, Akihiro Kuroda, Takuya Suyama, Masanori Seki, Atsushi Shinagawa
Oxford Medical Case Reports.2023;[Epub] CrossRef
Rare central nervous system lymphomas
Furqaan Ahmed Kaji, Nicolás Martinez‐Calle, Vishakha Sovani, Christopher Paul Fox
British Journal of Haematology.2022; 197(6): 662. CrossRef
Secondary parenchymal CNS involvement by lymphoma including rare types: Follicular and EBV-positive NK/T cell lymphoma, nasal type
B.K. Kleinschmidt-DeMasters, Ahmed Gilani
Annals of Diagnostic Pathology.2021; 53: 151765. CrossRef
Cerebral Amyloidoma Resulting from Central Nervous System Lymphoplasmacytic Lymphoma: A Case Report and Literature Review
Geetha Jagannathan, Guldeep Uppal, Kevin Judy, Mark T. Curtis
Case Reports in Pathology.2018; 2018: 1. CrossRef
Sites of extranodal involvement are prognostic in patients with stage 1 follicular lymphoma
Aditi Shastri, Murali Janakiram, Ioannis Mantzaris, Yiting Yu, Jaime S. Londono, Amit K. Verma, Stefan K. Barta
Oncotarget.2017; 8(45): 78410. CrossRef
Follicular Lymphoma Presenting with Leptomeningeal Disease
Rubens Costa, Ricardo Costa, Renata Costa
Case Reports in Hematology.2014; 2014: 1. CrossRef

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Original Article

A Case of Intracranial Involvement by Hodgkin's Disease: Man Jong Cho, Moo Jung Park, Jeong Pyo Hong, Sang Ho Lee, Ji Hyock Rhee, Yun Sik Yang, Sung Joo Lee; J Korean Cancer Assoc. 1996;28(4):776-782.

Abstract PDF: Intracranial involvement by Hodgkin's disease is rare. No particular risk factors have been uncovered which are associated with the development of intracranial disease. Intracranial involvement by Hodgkin's disease is exceedingly rare as an initial site of presentation, and in nearly all of the reported cases, intracranial disesse was associated with relapsing disease elsewhere. Here we report a 52 year old man who has paralytic strabismus due to abducens nerve palsy by relapsed Hodgkin's disease.

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