Cancer Research and Treatment

Case Report

A Case of Desmoplastic Small Round Cell Tumor Diagnosed in a Young Female Patient: Ji-Won Kim, Jin Hyun Park, Hyeon Jin Cho, Ji-Hyun Kwon, Youngil Koh, Su-Jung Kim, Se Hyung Kim, Se-Hoon Lee, Seock-Ah Im, Yong-Tae Kim, Woo Ho Kim; Cancer Res Treat. 2009;41(4):233-236. Published online December 31, 2009; DOI: https://doi.org/10.4143/crt.2009.41.4.233

Desmoplastic small round cell tumor is a very rare malignancy. We report the case of a 26-year-old woman who suffered from dyspepsia and abdominal pain for 2 months. We performed an endoscopic biopsy of the duodenal mass and diagnosed her disease as desmoplastic small round cell tumor using immunohistochemical staining, fluorescence in situ hybridization, and reverse transcriptase polymerase chain reaction. Because the mass invaded the pancreas and superior mesenteric vein as well as duodenum and the disease was disseminated to liver and peritoneum, she received palliative chemotherapy using vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide. The maximal response to chemotherapy was stable disease. The patient expired 9 months after diagnosis.

Citations

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A Case Report of Abdominal Desmoplastic Small Round Cell Tumor in a Young Tunisian Woman
Karim Nacef, Mohamed Ali Chaouch, Rym Bouriga, Mohamed Ben Khalifa, Asma Chaouch, Mossab Ghannouchi, Moez Boudokhane
Journal of Gastrointestinal Cancer.2019; 50(3): 568. CrossRef
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Journal of the Egyptian National Cancer Institute.2019;[Epub] CrossRef
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Andrés Alejandro Briseño-Hernández, Deissy Roxana Quezada-López, Lilia Edith Corona-Cobián, Agar Castañeda-Chávez, Alfonso Tonatiuh Duarte-Ojeda, Michel Dassaejv Macías-Amezcua
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Intra-abdominal desmoplastic small round cell tumour
Andrés Alejandro Briseño-Hernández, Deissy Roxana Quezada-López, Lilia Edith Corona-Cobián, Agar Castañeda-Chávez, Alfonso Tonatiuh Duarte-Ojeda, Michel Dassaejv Macías-Amezcua
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Primary desmoplastic small round cell tumor of the duodenum
Qi Liu, Nan Liu, DeXing Chen
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Tumor desmoplásico de células pequeñas y redondas. Diagnóstico y tratamiento
Izaskun Markinez Gordobil, Inmaculada Ruiz, Raúl Jiménez, Eloisa Villarreal, Aintzane Lizarazu, Nerea Borda, Xabier Arteaga, Miguel Ángel Medrano, Esther Guisasola, Adolfo Beguiristain, José María E. Navascués
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Desmoplastic small round cell tumor of the abdomen: A case report and literature review of therapeutic options
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Review Article

Tissue Array Methods for High-throughput Clinicopathologic Research: Hye Seung Lee, Woo Ho Kim; Cancer Res Treat. 2006;38(1):1-6. Published online February 28, 2006; DOI: https://doi.org/10.4143/crt.2006.38.1.1

Abstract PDF PubReader ePub

Recent research in molecular biology has identified a significant number of novel markers, which may have diagnostic, prognostic and therapeutic significance. High-throughput tissue array method facilitates the validation of novel markers by enabling the simultaneous analysis of hundreds or thousands of tissue specimens. Tissue array slides can be analyzed using techniques such as immunohistochemistry and in situ hybridization. In this review, we give a brief overview of tissue array method and its application to high throughput clinicopathologic research.

Citations

Citations to this article as recorded by

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Fibroblast Growth Factor Receptor 1 Gene Copy Number and mRNA Expression in Primary Colorectal Cancer and Its Clinicopathologic Correlation
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The Clinical Implication of Cancer-Associated Microvasculature and Fibroblast in Advanced Colorectal Cancer Patients with Synchronous or Metachronous Metastases
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Original Articles

Interphase Cytogenetic Analysis of Gastric Carcinogenesis using Chromosome in Situ Hybridization: Sun Young Kim, Ji Yun Bae, Jee Won Seo, Sang Suk Lee; J Korean Cancer Assoc. 1996;28(3):418-427.

Abstract PDF: Gastric cancer development has been proposed to present a multistep process characterized by dysregulation of proliferation and differentiation and driven by an accumulation of genetic alterations in anatomic field repeatedly exposed to carcinogens. As a first part,of research for gastric carcinogenesis and prevention, we probed 30 early gastric cancers and their adjacent normal tissue including premalignant lesions for numerical chromosome aberrations by nonisotopic, in situ hybridization using chromosome specific centromeric DNA probe for chromosome 17, to visualize the accumulation of genetic alterations during gastric carcinogenesis and to determine the extent of the genetically altered field. The mean chromosome index(CI) increased as the tissue passed from normal adjacent gland(NG) to intestinal metaplasia(IM) to cancer(EGC) (l.06, 1.12, 1.26). Moreover, the frequency of cells with chromosome polysomy (cells with 3 or more chromosome copies) increased as same pattern (4.2%, 9.4%, 20.2%). All cases with EGC, 28/30 cases with IM, 15/30 cases with NG showed significant polysomies(i.e., polysomy frequency > 3% of total populations). As a second part of investigation, 30 cases of gastric adenoma tissue were probe with same centromeric chromosome probes for 5 and 17, to visualize the genetic alteration of isolated benign or premalignant gastric lesion. The mean CI were 1.16 and 1.17, respectively and the frequency of polysomy were 7.6% and 4.0%, respectively. These findings of progressive genetic changes as the the tumor develops support the concept of multistep carcinogenesis and field cancerization. Such genetic parameters could serve as biomarkers of intermediate end points for risk assessment of progression to malignancy or chemoprevention trials.

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Expression of Epidermal Growht Factor Receptor mRNA by In Situ Hybridization in Breast Cancer: Won Jong Lee, Soo Jung Lee, Dong Sug Kim, Koing Bo Kwun, Min Chul Chim; J Korean Cancer Assoc. 1996;28(6):996-1010.

Abstract PDF: Epidermal growth factor(EGF) and epidermal growth factor receptor(EGFR) have been identified as one of the prognostic factor for breast cancer. EGFR status has been determined by several methods including competitive binding assay(BA), immunohistochemical stain(IHC), enzyme immunoassay(EIA). But EGFR could be masked by endogenous ligands in some proportion of tumors. So many different methods have been developed to detect EGFR mRNA. Among these methods, in situ hybridization with biotinylated probe found to be simple and rapid. In addition, it can determine intratumoral heterogenicity in gene expression and identify specific cells that contain a particular mRNA transcript. The author investigated the expression of EGFR mRNA in 81 human breast cancers by in situ hybridization(ISH) and compared the result with EGFR detected by IHC. The author also examined the relationship between EGFR mRNA expression and clinical parameters and other prognostic markers(estrogen receptor, progesterone receptor, p53, c-erbB-2). The author also studied the relationship between EGFR mRNA and recurrence and mortality rate. According to the degree of cytoplasmic staining in ISH assay, negative were 13 cases(16.1%), + were 41 cases(50.6%), ++ were 26 cases(32.1%) and +++ was 1 case(1.2%). The overall expression of EGFR mRNA was 84%. The positive staining of EGFR by IHC was observed either on the cell membrane alone or on both cell membrane and cytoplasm. EGFR by IHC were detected in 69.l%. The 19 cases(23.5%) of EGFR negative cases by IHC were demonstrated as + or more EGFR mRNA by ISH study. On the contrary, 7 cases(8.6%) of EGFR positive by IHC were not detected by ISH. The findings in the majority of the cases were same in two methods. EGFR mRNA had shown a significant positive correlation with c-erbB-2(p<0.009). But an inverse correlation with both estrogen receptor(p<0.027) and progesterone receptor(p<0.02) status, when ++ or more were regarded as positive staining in ISH. There were no correlation was found between positive EGFR by IHC and clinical parameters and other prognostic markers except c-erbB-2(p<0.05). Among the 11 cases of tumor containing both invasive ductal carcinoma and ductal carcinoma in situ(DCIS), there were 5 cases of + and 4 cases of ++ in invasive ductal carcinoma, but negative in these cases of DCIS by ISH. Although the cases with overexpression of EGFR mRNA showed a tendency of more recurrent rate and mortality rate, but there were no statistic significance during the short follow up period (24 months). In summery, EGFR mRNA thought to be a useful prognostic factor especially when over expression is more than ++ by ISH. In situ mRNA hybridization technique is more sensitive and more accurate than immunohistochemistry.

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