Cancer Research and Treatment

Original Articles

Head and Neck cancer

Radiotherapy versus Surgery in Early-Stage HPV-Positive Oropharyngeal Cancer: Dong-Yun Kim, Hong-Gyun Wu, Jin Ho Kim, Joo Ho Lee, Soon-Hyun Ahn, Eun-Jae Chung, Keun-Yong Eom, Young Ho Jung, Woo-Jin Jeong, Tack-Kyun Kwon, Suzy Kim, Chan Woo Wee; Cancer Res Treat. 2022;54(2):406-416. Published online June 23, 2021; DOI: https://doi.org/10.4143/crt.2021.441

Abstract PDF Supplementary Material PubReader ePub

Purpose
This study aimed to compare the outcomes of primary radiotherapy (RT) versus surgery in early-stage human papilloma virus–positive oropharyngeal squamous cell carcinoma (hpv+OPC), and investigate the preoperative clinical factors that can predict the requirement for postoperative adjuvant treatment.
Materials and Methods
This multicenter study included 166 patients with American Joint Committee on Cancer 8th edition-Stages I-II hpv+OPC. Sixty (36.1%) and 106 (63.9%) patients underwent primary (concurrent chemo)radiotherapy [(CC)RT] and surgery, respectively. Seventy-eight patients (73.6%) in the surgery group received postoperative (CC)RT.
Results
With a median follow-up of 45.6 months for survivors, the 2-year overall survival (OS), progression-free survival (PFS), and locoregional control (LC) for RT/surgery were 97.8%/96.4%, 91.1%/92.0%, and 92.9%/93.3%, respectively. In multivariate analyses, patients with synchronous radiologic extranodal extension and conglomeration (ENEcong) of metastatic lymph nodes (LNs) showed significantly poorer OS (p=0.047), PFS (p=0.001), and LC (p=0.003). In patients undergoing primary surgery, two or more clinically positive LN metastases (odds ratio [OR], 5.15; p=0.004) and LN metastases with ENEcong (OR, 3.75; p=0.009) were predictors of postoperative chemoradiotherapy. No patient in the primary RT group demonstrated late severe toxicity whereas three (2.8%), one (0.9%), and one (0.9%) patient in the surgery group showed grade 3 dysphagia, grade 3 xerostomia, and fatal oral cavity bleeding.
Conclusion
We found no differences in OS, PFS, and LC between upfront RT and surgery in stage I-II hpv+OPC which warrants comparison through a prospective trial in the treatment de-escalation era. However, most early-stage hpv+OPC patients undergoing surgery received adjuvant (CC)RT. Pretreatment LN findings were prognostic and predictive for adjuvant treatment.

Citations

Citations to this article as recorded by

Definitive radio(chemo)therapy versus upfront surgery in the treatment of HPV-related localized or locally advanced oropharyngeal squamous cell carcinoma
Jérémy Baude, Caroline Guigou, David Thibouw, Noémie Vulquin, Mireille Folia, Guillaume Constantin, Jihane Boustani, Christian Duvillard, Sylvain Ladoire, Gilles Truc, Aurélie Bertaut, Cédric Chevalier, Scott M. Langevin
PLOS ONE.2024; 19(7): e0307658. CrossRef
INFLUENCE OF CONFORMAL RADIOTHERAPY IN COMBINATION WITH RADIOMODIFIERS ON THE CONTENT OF VEGF, COX-2, AND PGE-2 IN BLOOD SERUM OF PATIENTS WITH HEAD AND NECK SQUAMOUS CELL CARCINOMA
N. MITRYAYEVA, L. GREBINYK, S. ARTIUKH, N. BILOZOR, V. STARENKIY
Experimental Oncology.2024; 46(3): 253. CrossRef
Assessment of Radiologic Extranodal Extension Using Combinatorial Analysis of Nodal Margin Breakdown and Metastatic Burden in Oropharyngeal Cancer
Sungryeal Kim, Hannah Park, Se Hyun Yeou, Jin Roh, Yoo Seob Shin, Chul-Ho Kim, Eun Ju Ha, Jeon Yeob Jang
Cancers.2023; 15(13): 3276. CrossRef
Expanding the role of combined immunochemotherapy and immunoradiotherapy in the management of head and neck cancer (Review)
Chun Wei, Xiaojun Lan, Maona Qiu, Ran Cui, Qiuxia Fu, Shafiu Umar Shinge, Tobias Muluh, Ou Jiang
Oncology Letters.2023;[Epub] CrossRef

7,880 View
222 Download
3 Web of Science
4 Crossref

The Increasing Frequency of Cervical Cancer in Korean Women under 35: Chan Hee Han, Hyun Jung Cho, Sung Jong Lee, Jeong Hoon Bae, Seog Nyen Bae, Sung Eun Namkoong, Jong Sup Park; Cancer Res Treat. 2008;40(1):1-5. Published online March 31, 2008; DOI: https://doi.org/10.4143/crt.2008.40.1.1

Abstract PDF PubReader ePub

Purpose

The goal of this study was to determine the clinical and epidemiological trends of cervical cancer in young Korean women. Social behavior including sexual habits has changed in Korean women, with sexual activity commencing at a younger age. These changes are likely to influence certain risk factors of cervical cancer, resulting in changing trends in the occurrence of the disease.

Materials and Methods

The incidence of cervical cancer in women less than 35 years-old between January 1990 and December 2006 was analyzed, and available medical records from January 1996 to December 2006 were reviewed. The clinical, pathological and epidemiologic characteristics and changing trends among these young patients were analyzed.

Results

Over the last two decades, the incidence of young (< 35 years) cervical cancer patients increased, more patients had an aggressive form of the disease, and there was a higher rate of women with more advanced education. Human papillomavirus (HPV) infection was detected in 94.0% of the women (63/67) tested. HPV 16 (82.5%) and HPV 18 (12.7%) were the two most common viral infections detected throughout the study period.

Conclusions

The changing trends and risk factors identified suggest a need for more active education of young women about cervical cancer prevention strategies. In addition, young women are strongly recommended to undergo a regular screening test and HPV vaccination.

Citations

Citations to this article as recorded by

Prevalence and Treatment of Vulvar Cancer From 2014−2018: A Nationwide Population-Based Study in Korea
Yung-Taek Ouh, Dongwoo Kang, Hoseob Kim, Jae Kwan Lee, Jin Hwa Hong
Journal of Korean Medical Science.2022;[Epub] CrossRef
Successful Treatment of Synchronous Double Lung Primary Malignancies and Colon Cancer
Hosam A Alghanmi
Cureus.2022;[Epub] CrossRef
WITHDRAWN: Polymerase chain reaction technique for molecular detection of HPV16 infections among women with cervical cancer in Dhi-Qar Province
Abduladheem Turki Jalil, Ali Hussein Demin Al-Khafaji, Aleksandr Karevskiy, Saja Hussain Dilfy, Zaman K. Hanan
Materials Today: Proceedings.2021;[Epub] CrossRef
Current Status of Human Papillomavirus Infection and Introduction of Vaccination to the National Immunization Program in Korea: an Overview
Min-A Kim, Gwan Hee Han, Jae-Hoon Kim, Kyung Seo
Journal of Korean Medical Science.2018;[Epub] CrossRef
Management for locally advanced cervical cancer: new trends and controversial issues
Oyeon Cho, Mison Chun
Radiation Oncology Journal.2018; 36(4): 254. CrossRef
Trends and Age-Period-Cohort Effects on the Incidence and Mortality Rate of Cervical Cancer in Korea
Eun-Kyeong Moon, Chang-Mo Oh, Young-Joo Won, Jong-Keun Lee, Kyu-Won Jung, Hyunsoon Cho, Jae Kwan Jun, Myong Cheol Lim, Moran Ki
Cancer Research and Treatment.2017; 49(2): 526. CrossRef
Factors associated with participation in cervical cancer screening among young Koreans: a nationwide cross-sectional study
Ha Kyun Chang, Jun-Pyo Myong, Seung Won Byun, Sung-Jong Lee, Yong Seok Lee, Hae-Nam Lee, Keun Ho Lee, Dong Choon Park, Chan Joo Kim, Soo Young Hur, Jong Sup Park, Tae Chul Park
BMJ Open.2017; 7(4): e013868. CrossRef
Molecular Detection and Typing of Human Papillomaviruses in Paraffin-Embedded Cervical Cancer and Pre-Cancer Tissue Specimens
Pezhman Mahmoodi, Hossein Motamedi, Masoud Reza Seyfi Abad Shapouri, Mahjabin Bahrami Shehni, Mohammad Kargar
Iranian Journal of Cancer Prevention.2016;[Epub] CrossRef
Cervical cancer in north-eastern Libya: 2000–2008
F. Ben Khaial, Z. Bodalal, A. Elramli, F. Elkhwsky, A. Eltaguri, R. Bendardaf
Journal of Obstetrics and Gynaecology.2014; 34(6): 523. CrossRef
Current status of the National Cancer Screening Program for cervical cancer in Korea, 2009
Young Hwa Lee, Kui Son Choi, Hoo-Yeon Lee, Jae Kwan Jun
Journal of Gynecologic Oncology.2012; 23(1): 16. CrossRef
Laparoscopic versus open radical hysterectomy in early-stage cervical cancer: long-term survival outcomes in a matched cohort study
J.-H. Nam, J.-Y. Park, D.-Y. Kim, J.-H. Kim, Y.-M. Kim, Y.-T. Kim
Annals of Oncology.2012; 23(4): 903. CrossRef
The safety of conization in the management of adenocarcinomain situof the uterine cervix
Mi-La Kim, Ho-Suap Hahn, Kyung-Taek Lim, Ki-Heon Lee, Hy-Sook Kim, Sung-Ran Hong, Tae-Jin Kim
Journal of Gynecologic Oncology.2011; 22(1): 25. CrossRef
Human papillomavirus 16/18 AS04-adjuvanted cervical cancer vaccine: immunogenicity and safety in 15-25 years old healthy Korean women
Seung Cheol Kim, Yong Sang Song, Young-Tae Kim, Young Tak Kim, Ki-Sung Ryu, Bhavyashree Gunapalaiah, Dan Bi, Hans L Bock, Jong-Sup Park
Journal of Gynecologic Oncology.2011; 22(2): 67. CrossRef
Prognostic value of metabolic tumor volume measured by FDG-PET/CT in patients with cervical cancer
Hyun Hoon Chung, Jae Weon Kim, Kyung Hee Han, Jae Seon Eo, Keon Wook Kang, Noh-Hyun Park, Yong-Sang Song, June-Key Chung, Soon-Beom Kang
Gynecologic Oncology.2011; 120(2): 270. CrossRef

12,919 View
130 Download
14 Crossref

Review Article

The Role of HPV E6 and E7 Oncoproteins in HPV-associated Cervical Carcinogenesis: Eun-Kyoung Yim, Jong-Sup Park; Cancer Res Treat. 2005;37(6):319-324. Published online December 31, 2005; DOI: https://doi.org/10.4143/crt.2005.37.6.319

Abstract PDF PubReader ePub

Cervical cancer is one of the leading world causes of cancer morbidity and mortality in woman, with more than 98% related to a human papillomavirus (HPV) infection origin. Infection with specific subtypes of HPV has been strongly implicated in cervical carcinogenesis. The identification and functional verification of host proteins associated with HPV E6 and E7 oncoproteins may provide useful information in understanding cervical carcinogenesis and the development of cervical cancer-specific markers. The advent of functional genomics and proteomics has provided hope of discovering novel biological markers for use in the screening, early diagnosis, prognostication and prediction of response to therapy. Herein, we review the studies where the profiles of host proteins associated with HPV E6 and E7 oncoproteins in cervical cancer were generated.

Citations

Citations to this article as recorded by

Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage
Radoslaw Szmyd, Sienna Casolin, Lucy French, Anna G. Manjón, Melanie Walter, Léa Cavalli, Christopher B. Nelson, Scott G. Page, Andrew Dhawan, Eric Hau, Hilda A. Pickett, Harriet E. Gee, Anthony J. Cesare
Nature Cell Biology.2025; 27(1): 59. CrossRef
Oncoproteins E6/E7 of the human papillomavirus types 16 & 18 synergize in modulating oncogenes and tumor suppressor proteins in colorectal cancer
Queenie Fernandes, Lubna Therachiyil, Shahd M Younis, Said Dermime, Ala-Eddin Al Moustafa
Expert Review of Proteomics.2025; : 1. CrossRef
Regulation of Granzymes A and B by High-Risk HPV: Impact on Immune Evasion and Carcinogenesis
Mashego Nathan Maleka, Zukile Mbita, Vivian Morafo
Viruses.2025; 17(2): 221. CrossRef
Penile Cancer: Innovations in Ultrastructural and Vibrational Markers
Joel Félix Silva Diniz-Filho, Ana Caroline Muniz Silva, Antônio Augusto Lima Teixeira, Bruna Larissa Nolêto Sousa, Ralph Santos-Oliveira, Gyl Eanes Barros Silva, Clenilton Costa dos Santos, Luciana Magalhães Rebelo Alencar
ACS Omega.2025; 10(4): 3449. CrossRef
Development and evaluation of a novel E7 multi-epitopic vaccine for human papillomavirus type 16: design, expression, purification, and immunological characterization
Bahareh Bahmani, Zahra Amini-bayat, Mohammad Mehdi Ranjbar, Masoud Hassanzadeh Makoui, Amir-Hassan Zarnani
BMC Infectious Diseases.2025;[Epub] CrossRef
A paper-based HPV E7 oncoprotein assay for cervical precancer detection at the point of care
Chelsey A. Smith, Sai Paul, Karen E. Haney, Sonia G. Parra, Meaghan Bond, Leticia López, Mauricio Maza, Juan Felix, Preetha Ramalingam, Pablo Escobar, Philip E. Castle, Kathleen M. Schmeler, Rebecca R. Richards-Kortum
Scientific Reports.2025;[Epub] CrossRef
Downregulation of LAMB3 Altered the Carcinogenic Properties of Human Papillomavirus 16-Positive Cervical Cancer Cells
Warattaya Wattanathavorn, Masahide Seki, Yutaka Suzuki, Supranee Buranapraditkun, Nakarin Kitkumthorn, Thanayod Sasivimolrattana, Parvapan Bhattarakosol, Arkom Chaiwongkot
International Journal of Molecular Sciences.2024; 25(5): 2535. CrossRef
It Is All about Probiotics to Control Cervical Cancer
Sumel Ashique, Abdul Faruk, Farhan Jalees Ahmad, Tasneem Khan, Neeraj Mishra
Probiotics and Antimicrobial Proteins.2024; 16(3): 979. CrossRef
Down-regulation of human papillomavirus E6 oncogene and antiproliferative effect of Schisandra chinensis and Pueraria lobata natural extracts on Hela cell line
Andrés Cardona-Mendoza, Angela Fonseca-Benitez, Diana Marcela Buitrago, Ericsson Coy-Barrera, Sandra J. Perdomo
Journal of Ethnopharmacology.2024; 319: 117225. CrossRef
HPV16 E6/E7-mediated regulation of PiwiL1 expression induces tumorigenesis in cervical cancer cells
Midhunaraj Kunnummal, Pooja Sherly Raveendran, Budhaditya Basu, Sheri Vidya Rani, Riya Ann Paul, Krithiga Kuppusamy, Mary Angelin, Joby Issac, Jackson James, Ani V. Das
Cellular Oncology.2024; 47(3): 917. CrossRef
Cis‐regulatory effect of HPV integration is constrained by host chromatin architecture in cervical cancers
Anurag Kumar Singh, Kaivalya Walavalkar, Daniele Tavernari, Giovanni Ciriello, Dimple Notani, Radhakrishnan Sabarinathan
Molecular Oncology.2024; 18(5): 1189. CrossRef
The microbiome and gynecologic cancer: cellular mechanisms and clinical applications
Julia Chalif, Heather Wang, Daniel Spakowicz, Allison Quick, Elizabeth K Arthur, David O’Malley, Laura M Chambers
International Journal of Gynecological Cancer.2024; 34(2): 317. CrossRef
Infectious pathogens and risk of esophageal, gastric and duodenal cancers and ulcers in China: A case‐cohort study
Christiana Kartsonaki, Pang Yao, Julia Butt, Rima Jeske, Catherine de Martel, Martyn Plummer, Dianjianyi Sun, Sarah Clark, Robin G. Walters, Yiping Chen, Jun Lv, Canqing Yu, Michael Hill, Richard Peto, Liming Li, Tim Waterboer, Zhengming Chen, Iona Y. Mil
International Journal of Cancer.2024; 154(8): 1423. CrossRef
Serum oxidative biomarkers associated with genital HPV infection and cervical lesions in women
Hui‐Yi Lin, Xiaodan Zhu, Harun Or Rashid Mazumder, Martin Ronis, Kim Brint Pedersen, Michael Hagensee
Journal of Medical Virology.2024;[Epub] CrossRef
Combined amplification-based single-molecule fluorescence in situ hybridization with immunofluorescence for simultaneous in situ detection of RNAs and proteins
Yinghui Qiu, Kaipeng Wei, Hui Lin, Yanxiu Liu, Chen Lin, Rongqin Ke
Biochemical and Biophysical Research Communications.2024; 696: 149508. CrossRef
PARP1, DIDO3, and DHX9 Proteins Mutually Interact in Mouse Fibroblasts, with Effects on DNA Replication Dynamics, Senescence, and Oncogenic Transformation
Agnes Fütterer, Sara Rodriguez-Acebes, Juan Méndez, Julio Gutiérrez, Carlos Martínez-A
Cells.2024; 13(2): 159. CrossRef
Technologies of gene editing and related clinical trials for the treatment of genetic and acquired diseases: a systematic review
Wessam Sharaf-Eldin
Egyptian Journal of Medical Human Genetics.2024;[Epub] CrossRef
The role of viruses in cancer progression versus cancer treatment: A dual paradigm
Somya Ranjan Dash, Anushka Kundu, Chanakya Nath Kundu
Life Sciences.2024; 341: 122506. CrossRef
Epigallocatechin Gallate for the Treatment of Benign and Malignant Gynecological Diseases—Focus on Epigenetic Mechanisms
Marta Włodarczyk, Michał Ciebiera, Grażyna Nowicka, Tomasz Łoziński, Mohamed Ali, Ayman Al-Hendy
Nutrients.2024; 16(4): 559. CrossRef
Unveiling HPV's hidden link: Cardiovascular diseases and the viral intrigue
Preyangsee Dutta, Dwaipayan Saha, Mrudul Earle, Chandra Prakash Prasad, Mayank Singh, Mrinalini Darswal, Vipul Aggarwal, Nitish Naik, Rakesh Yadav, Abhishek Shankar, Abhijit Chakraborty
Indian Heart Journal.2024; 76(1): 1. CrossRef
Regulation and tumor‐suppressive function of the miR‐379/miR‐656 (C14MC) cluster in cervical cancer
Sriharikrishnaa Srinath, Padacherri Vethil Jishnu, Vinay Koshy Varghese, Vaibhav Shukla, Divya Adiga, Sandeep Mallya, Sanjiban Chakrabarty, Krishna Sharan, Deeksha Pandey, Aniruddha Chatterjee, Shama Prasada Kabekkodu
Molecular Oncology.2024; 18(6): 1608. CrossRef
Comprehensive analysis of a novel subtype of immune microenvironment-derived HPV-infected colorectal cancer
Jianlong Zhou, Yongfeng Liu, Yucheng Zhang, Fa Ling, Jiabin Zheng, Xueqing Yao, Zejian Lyu, Huolun Feng, Yong Li
Microbes and Infection.2024; 26(4): 105315. CrossRef
Evolution of Pathological Techniques for the Screening of Cervical Cancer: A Comprehensive Review
Priya B Chatterjee, Snehlata R Hingway, Kishor M Hiwale
Cureus.2024;[Epub] CrossRef
Therapeutic Response to Treatment of a Papillomatous Ocular Surface Squamous Neoplasia With Intramuscular Human Papillomavirus Vaccine
Mike Zein, Sofia De Arrigunaga, Mona M. Amer, Anat Galor, Anna J. Nichols, Tim Ioannides, Sander R. Dubovy, Carol L. Karp
Cornea.2024;[Epub] CrossRef
BRCA1 deficiency enhances the aggressiveness of breast cancer cells expressing HPV16 oncoproteins
Jariya Sangthong, Chanitra Thuwajit, Laran T. Jensen, Waraporn Komyod, Jirundon Yuvaniyama, Mathurose Ponglikitmongkol
Biology of the Cell.2024;[Epub] CrossRef
Exploring the Relationship between Ovarian Cancer and Genital Microbiota: A Systematic Review and Meta-Analysis
Vito Andrea Capozzi, Giosuè Giordano Incognito, Elisa Scarpelli, Marco Palumbo, Cinzia Lucia Randazzo, Alessandra Pino, Marco La Verde, Carlo Ronsini, Gaetano Riemma, Michela Gaiano, Paola Romeo, Vittorio Palmara, Roberto Berretta, Stefano Cianci
Journal of Personalized Medicine.2024; 14(4): 351. CrossRef
Virus-like Particles for Disease Diagnosis and Drug Delivery Applications
Rishav Sharma, Rishabha Malviya
Current Nanoscience.2024; 20(5): 613. CrossRef
Biplex quantitative PCR to detect transcriptionally active human papillomavirus 16 from patient saliva
Fiona Deutsch, Dayna Sais, Ni Keatinge, Meredith Hill, Ngoc Ha Tran, Michael Elliott, Nham Tran
BMC Cancer.2024;[Epub] CrossRef
Biochemical and toxicity evaluation of Retama sphaerocarpa extracts and in-silico investigation of phenolic compounds as potential inhibitors against HPV16 E6 oncoprotein
Soumia Moujane, Ismail Bouadid, Aziz Bouymajane, Filali Zegzouti Younes, Mohamed Benlyas, Bouachrine Mohammed, Francesco Cacciola, Roberto Laganà Vinci, Alessia Tropea, Luigi Mondello, Ammar B. Altemimi, Mohamed Eddouks, Benaissa Moualij
Fitoterapia.2024; 175: 105923. CrossRef
Viruses in glioblastoma: an update on evidence and clinical trials
Bavani Gunasegaran, Caroline L. Ashley, Felix Marsh-Wakefield, Gilles J. Guillemin, Benjamin Heng
BJC Reports.2024;[Epub] CrossRef
Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activity
Alan S. Futran, Tao Lu, Katherine Amberg-Johnson, Jiayi Xu, Xiaoxiao Yang, Saidi He, Sarah Boyce, Jeffrey A. Bell, Robert Pelletier, Takao Suzuki, Xianhai Huang, Heng Qian, Liping Fang, Li Xing, Zhaowu Xu, Stephen E. Kurtz, Jeffrey W. Tyner, Wayne Tang, T
iScience.2024; 27(5): 109693. CrossRef
Emerging biomarkers and molecular targets for precision medicine in cervical cancer
Pankaj Garg, Madhu Krishna, Ayalur Raghu Subbalakshmi, Sravani Ramisetty, Atish Mohanty, Prakash Kulkarni, David Horne, Ravi Salgia, Sharad S. Singhal
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2024; 1879(3): 189106. CrossRef
Unfurling the functional association between long intergenic noncoding RNAs (lincRNAs) and HPV16-related cervical cancer pathogenesis through weighted gene co-expression network analysis of differentially expressed lincRNAs and coding genes
Abarna Sinha, Sahana Ghosh, Abhisikta Ghosh, Arnab Ghosh, Sonia Mathai, Jaydip Bhaumik, Asima Mukhopadhyay, Arindam Maitra, Nidhan K Biswas, Sharmila Sengupta
Carcinogenesis.2024; 45(7): 451. CrossRef
Two Lineages of Papillomaviruses Identified from Caracals (Caracal caracal) in South Africa
Simona Kraberger, Laurel E. K. Serieys, Gabriella R. M. Leighton, Matthew D. De Koch, John S. Munday, Jacqueline M. Bishop, Arvind Varsani
Viruses.2024; 16(5): 701. CrossRef
Molecular Typing of Human Leukocyte Antigen-Class I (HLA-A, HLA-B) & Human Leukocyte Antigen-Class II (HLA-DR) in Carcinoma Cervix and Its Association with Staging
Sumanta Das, Mukul Singh, Anjali Sharma, R. Naveen Kumar, Adil Aziz Khan
Indian Journal of Gynecologic Oncology.2024;[Epub] CrossRef
Tumor-Derived Antigenic Peptides as Potential Cancer Vaccines
Stanislav Sotirov, Ivan Dimitrov
International Journal of Molecular Sciences.2024; 25(9): 4934. CrossRef
CRL4-DCAF1 Ubiquitin Ligase Dependent Functions of HIV Viral Protein R and Viral Protein X
Ashley Dobransky, Mary Root, Nicholas Hafner, Matty Marcum, H. John Sharifi
Viruses.2024; 16(8): 1313. CrossRef
Impact of human papillomavirus types on uterine cervical neoplasia
Ayumi Taguchi, Daisuke Yoshimoto, Misako Kusakabe, Satoshi Baba, Akira Kawata, Yuichiro Miyamoto, Mayuyo Mori, Kenbun Sone, Yasushi Hirota, Yutaka Osuga
Journal of Obstetrics and Gynaecology Research.2024; 50(8): 1283. CrossRef
Quantification of HPV16 E7 Oncoproteins in Urine Specimens from Women with Cervical Intraepithelial Neoplasia
Daiki Makioka, Mikio Inada, Masayuki Awano, Ema Saito, Takuya Shinoda, Satoko Abe, Teruki Yoshimura, Martin Müller, Toshiyuki Sasagawa, Etsuro Ito
Microorganisms.2024; 12(6): 1205. CrossRef
Assessing bias in the causal role of HPV in oral cancer: A systematic review and meta‐analysis
Gagandeep Kaur, Tami Yap, Rishi Ramani, Michael McCullough, Ankur Singh
Oral Diseases.2024; 30(8): 5379. CrossRef
Current status and future directions for the development of human papillomavirus vaccines
Rui Wang, Hongpeng Huang, Chulin Yu, Xuefeng Li, Yang Wang, Liangzhi Xie
Frontiers in Immunology.2024;[Epub] CrossRef
Exosome‐based therapy and targeted PROTAC delivery: A new nanomedicine frontier for HPV‐mediated cervical cancer treatment
Nobendu Mukerjee, Swastika Maitra, Arabinda Ghosh
Clinical and Translational Discovery.2024;[Epub] CrossRef
Human papillomavirus‐16 E6‐positive cervical cancer attenuated by potent 2‐(4‐biphenylyl)‐N‐(1‐ethyl‐4‐piperidinyl) acetamide second‐generation analogs with improved binding affinity
Ashish Kumar
Biotechnology and Applied Biochemistry.2024; 71(6): 1428. CrossRef
Transforming growth factor-β micro-environment mediated immune cell functions in cervical cancer
Jayapradha Gnanagurusamy, Sneha Krishnamoorthy, Sridhar Muthusami
International Immunopharmacology.2024; 140: 112837. CrossRef
Harnessing virulence factor-derived peptides for innovative oral cancer treatment
Karthikeyan Kandaswamy, Ajay Guru
Natural Product Research.2024; : 1. CrossRef
Oncoviral Infections and Small Extracellular Vesicles
Łukasz Ważny, Theresa L. Whiteside, Monika Pietrowska
Viruses.2024; 16(8): 1291. CrossRef
Therapeutic Strategies in Advanced Cervical Cancer Detection, Prevention and Treatment
Xolisiwe Sebutsoe, Nrateng Tsotetsi, Zodwa Jantjies, Portia Pheladi Raphela-Choma, Mpho Choene, lesetja R Motadi
OncoTargets and Therapy.2024; Volume 17: 785. CrossRef
Bovine papillomavirus gene expression and inflammatory pathway activation vary between equine sarcoid tumour subtypes
Nicholas J. Parkinson, Abby Ward, Alexandra J. Malbon, Richard J.M. Reardon, Padraig G. Kelly
Veterinary Immunology and Immunopathology.2024; 277: 110838. CrossRef
Small non-coding RNAs as diagnostic, prognostic and predictive biomarkers of gynecological cancers: an update
Marios A. Diamantopoulos, Panagiotis G. Adamopoulos, Andreas Scorilas
Expert Review of Molecular Diagnostics.2024; 24(11): 979. CrossRef
The role of transforming growth factor β in cervical carcinogenesis
Kleber Paiva Trugilo, Guilherme Cesar Martelossi Cebinelli, Eliza Pizarro Castilha, Mariane Ricciardi da Silva, Fernanda Costa Brandão Berti, Karen Brajão de Oliveira
Cytokine & Growth Factor Reviews.2024; 80: 12. CrossRef
A Self-Amplifying Human Papillomavirus 16 Vaccine Candidate Delivered by Tobacco Mosaic Virus-Like Particles
Sweta Karan, Jessica Fernanda Affonso De Oliveira, Miguel A. Moreno-Gonzalez, Nicole F. Steinmetz
ACS Applied Bio Materials.2024; 7(11): 7675. CrossRef
A State‐of‐the‐Art Review on the Recent Advances in Exosomes in Oncogenic Virus
Fatemeh Ebrahimi, Ali Modaresi Movahedi, Mohammad Sabbaghian, Vahdat Poortahmasebi
Health Science Reports.2024;[Epub] CrossRef
miRNAs Dysregulated in Human Papillomavirus-Associated Benign Prostatic Lesions and Prostate Cancer
Sandra Viridiana Salgado-Hernández, Lucero Martínez-Retamoza, Rodolfo Ocadiz-Delgado, Salvador Pérez-Mora, Gladys Edith Cedeño-Arboleda, María del Consuelo Gómez-García, Patricio Gariglio, David Guillermo Pérez-Ishiwara
Cancers.2024; 17(1): 26. CrossRef
Association between mutant E6 and E7 Human Papilloma Virus Type 16 oncogenes with cyclin D1 expression in cervical cancer: Observational study in Bali
I Nyoman Bayu Mahendra, I Nyoman Gede Budiana, I Gede Mega Putra, Anom Suardika, Anak Agung Gede Putra Wiradnyana, Alisza Novrita Sari
F1000Research.2023; 12: 257. CrossRef
Human papillomavirus infection, cervical cancer and the less explored role of trace elements
Anne Boyina Sravani, Vivek Ghate, Shaila Lewis
Biological Trace Element Research.2023; 201(3): 1026. CrossRef
Viral subversion of the cell polarity regulator Scribble
Airah Javorsky, Patrick O. Humbert, Marc Kvansakul
Biochemical Society Transactions.2023;[Epub] CrossRef
High nuclear expression of DNMT1 in correlation with inactivation of TET1 portray worst prognosis among the cervical carcinoma patients: clinical implications
Priyanka Dutta, Mukta Basu, Anup Roy, Ranajit Kumar Mandal, Chinmay Kumar Panda
Journal of Molecular Histology.2023; 54(1): 89. CrossRef
p15INK4B is an alternative marker of senescent tumor cells in colorectal cancer
Soon Sang Park, Young-Kyoung Lee, So Hyun Park, Su Bin Lim, Yong Won Choi, Jun Sang Shin, Young Hwa Kim, Jang-Hee Kim, Tae Jun Park
Heliyon.2023; 9(2): e13170. CrossRef
Evaluation of the proteomic landscape of HPV E7‑induced alterations in human keratinocytes reveal therapeutically relevant pathways for cervical cancer
Sivasangkary Gandhi, Muhammad Fazril Mohamad Razif, Shatrah Othman, Sajib Chakraborty, Nurshamimi Nor Rashid
Molecular Medicine Reports.2023;[Epub] CrossRef
Immune Environment and Immunotherapy in Endometrial Carcinoma and Cervical Tumors
Alexandra Lainé, Andrea M. Gonzalez-Lopez, Uzma Hasan, Ryotaro Ohkuma, Isabelle Ray-Coquard
Cancers.2023; 15(7): 2042. CrossRef
Drug repurposing for viral cancers: A paradigm of machine learning, deep learning, and virtual screening‐based approaches
Faheem Ahmed, In Suk Kang, Kyung Hwan Kim, Arun Asif, Chethikkattuveli Salih Abdul Rahim, Anupama Samantasinghar, Fida Hussain Memon, Kyung Hyun Choi
Journal of Medical Virology.2023;[Epub] CrossRef
Protein–DNA Interactions Regulate Human Papillomavirus DNA Replication, Transcription, and Oncogenesis
Roxanne Evande, Anshul Rana, Esther E. Biswas-Fiss, Subhasis B. Biswas
International Journal of Molecular Sciences.2023; 24(10): 8493. CrossRef
Histopathologic and molecular characterization of Erethizon dorsatum papillomavirus 1 and Erethizon dorsatum papillomavirus 2 infection in North American porcupines (Erethizon dorsatum)
Zoe E. Mack, Leonardo C. Caserta, Randall W. Renshaw, Shotaro Nakagun, Rhea S. Gerdes, Diego G. Diel, Sara E. Childs-Sanford, Jeanine Peters-Kennedy
Veterinary Pathology.2023; 60(6): 898. CrossRef
Whole-Genome Doubling as a source of cancer: how, when, where, and why?
Natalia Sanz-Gómez, María González-Álvarez, Javier De Las Rivas, Guillermo de Cárcer
Frontiers in Cell and Developmental Biology.2023;[Epub] CrossRef
Retrospective Phylodynamic and Phylogeographic Analysis of the Human Papillomavirus 16 E6 Gene in the Mediterranean Region
Oussama Souiai, Ameni Sallemi
Bioinformatics and Biology Insights.2023;[Epub] CrossRef
MicroRNAs as Potential Biomarkers in Gynecological Cancers
Joanna Miśkiewicz, Aleksandra Mielczarek-Palacz, Joanna Magdalena Gola
Biomedicines.2023; 11(6): 1704. CrossRef
Impact of Dietary Quality on Genital Oncogenic Human Papillomavirus Infection in Women
Hui-Yi Lin, Qiufan Fu, Tung-sung Tseng, Xiaodan Zhu, Krzysztof Reiss, L Joseph Su, Michael E Hagensee
The Journal of Infectious Diseases.2023; 228(10): 1385. CrossRef
Prevalence of P16 Immunohistochemistry Positive Staining and Its Correlation to Clinical and Radiological Staging of Squamous Cell Carcinoma of the Cervix
Hossam H. El Sokkary, Eman Sheta
The Journal of Obstetrics and Gynecology of India.2023; 73(S1): 142. CrossRef
HPV-associated cancers: insights into the mechanistic scenario and latest updates
Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Abilash Valsala Gopalakrishnan, Rama Jayaraj, Ramkumar Katturajan, Sandra Kannampuzha, Reshma Murali, Arunraj Namachivayam, Sabina Evan Prince, Balachandar Vellingiri, Abhijit Dey, Kaviyarasi Renu
Medical Oncology.2023;[Epub] CrossRef
Genome editing mRNA nanotherapies inhibit cervical cancer progression and regulate the immunosuppressive microenvironment for adoptive T-cell therapy
Kaijian Ling, Yin Dou, Neng Yang, Li Deng, Yanzhou Wang, Yudi Li, Leiyan Yang, Cheng Chen, Lupin Jiang, Qingchun Deng, Chenwen Li, Zhiqing Liang, Jianxiang Zhang
Journal of Controlled Release.2023; 360: 496. CrossRef
Viral manipulation of cell polarity signalling
Airah Javorsky, Patrick O. Humbert, Marc Kvansakul
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2023; 1870(7): 119536. CrossRef
The Undefinable Links: Unraveling the Mysterious Relationships Between Viruses and the Human
Yuening Li
Highlights in Science, Engineering and Technology.2023; 54: 397. CrossRef
Herpes Simplex Virus, Human Papillomavirus, and Cervical Cancer: Overview, Relationship, and Treatment Implications
Daniel Sausen, Oren Shechter, Elisa Gallo, Harel Dahari, Ronen Borenstein
Cancers.2023; 15(14): 3692. CrossRef
The potential role of the microbiota in prostate cancer pathogenesis and treatment
Nicolò Pernigoni, Christina Guo, Lewis Gallagher, Wei Yuan, Manuel Colucci, Martina Troiani, Lei Liu, Luisa Maraccani, Ilaria Guccini, Denis Migliorini, Johann de Bono, Andrea Alimonti
Nature Reviews Urology.2023; 20(12): 706. CrossRef
Clinicopathologic and Molecular Characterization of Anorectal Neuroendocrine Carcinomas Reveals Human Papillomavirus, p53, and c-Myc as Alternative Mechanisms of Carcinogenesis
Allison J. Cox, William E. Crowe, Qi Yang, Bin Zhang, Zoltán N. Oltvai, Xiaoyan Liao
Modern Pathology.2023; 36(11): 100295. CrossRef
An updated systemic review and meta-analysis on human papillomavirus in breast carcinogenesis
Usman Ayub Awan, Aamer Ali Khattak, Noman Ahmed, Xingyi Guo, Sohail Akhtar, Shehrish Kamran, Zhao Yongjing, Jianbo Liu, Suliman Khan
Frontiers in Oncology.2023;[Epub] CrossRef
Role of MLH1 and MSH2 deficiency in the development of tumorigenesis and chemo-tolerance of cervical Carcinoma: Clinical implications
Priyanka Dutta, Debolina Pal, Anup Roy, Ranajit Kumar Mandal, Chinmay Kumar Panda
Gene.2023; 888: 147746. CrossRef
Detection of High-Grade Cervical Intraepithelial Neoplasia by Electrical Impedance Spectroscopy in Women Diagnosed with Low-Grade Cervical Intraepithelial Neoplasia in Cytology
Georgios Panagakis, Ioannis K. Papapanagiotou, Charalampos Theofanakis, Paraskevi Tsetsa, Adamantia Kontogeorgi, Nikolaos Thomakos, Alexandros Rodolakis, Dimitrios Haidopoulos
Life.2023; 13(11): 2139. CrossRef
MULTİPL SKLEROZ HASTALARINDA SERVİKAL DİSPLAZİ RİSKİ
Özlem Kayacık Günday, Gökçe Zeytin Demiral, Şerafettin Baysal, Tacettin Sevim, Selin Yoldaş, Berkay Çelebi, Ensar Çam
Kocatepe Tıp Dergisi.2023; 24(4): 493. CrossRef
p16/Ki67 dual stain triage versus cytology in primary human papillomavirus‐based cervical cancer screening with limited genotyping
Martyna Trzeszcz, Maciej Mazurec, Robert Jach, Karolina Mazurec, Izabela Kotkowska‐Szeps, Magdalena Kania, Mariola Wantuchowicz, Jolanta Wasowska, Monika Duczek‐Polakiewicz, Patrycja Rozmus, Joanna Streb, Agnieszka Halon
Journal of Medical Virology.2023;[Epub] CrossRef
From Diagnosis to Treatment: Exploring the Latest Management Trends in Cervical Intraepithelial Neoplasia
Saloni Gupta, Nikhilesh Nagtode, Vaibhav Chandra, Kavita Gomase
Cureus.2023;[Epub] CrossRef
Regulatory Effect of Ficus carica Latex on Cell Cycle Progression in Human Papillomavirus-Positive Cervical Cancer Cell Lines: Insights from Gene Expression Analysis
Muharrem Cakir, Ugur Bilge, Arshia Ghanbari, G. Ashrafi
Pharmaceuticals.2023; 16(12): 1723. CrossRef
Leveraging innovative therapies with an evolving understanding of the molecular pathogenesis of penile squamous cell carcinoma
Ali Hajiran, Taylor Bracco, Logan Zemp, Philippe E. Spiess
Urologic Oncology: Seminars and Original Investigations.2022; 40(5): 173. CrossRef
Antioxidant and Cytotoxic Activities of Exopolysaccharides from Alcaligenes faecalis Species Isolated from the Marine Environment of Mauritius
Aadil Ahmad Aullybux, Daneshwar Puchooa, Theeshan Bahorun, Rajesh Jeewon, Xuesong Wen, Poona Matin
Journal of Polymers and the Environment.2022; 30(4): 1462. CrossRef
Molecular landscape of vulvovaginal squamous cell carcinoma: new insights into molecular mechanisms of HPV-associated and HPV-independent squamous cell carcinoma
Abeer M. Salama, Amir Momeni-Boroujeni, Chad Vanderbilt, Marc Ladanyi, Robert Soslow
Modern Pathology.2022; 35(2): 274. CrossRef
Haemophilus pittmaniae and Leptotrichia spp. Constitute a Multi-Marker Signature in a Cohort of Human Papillomavirus-Positive Head and Neck Cancer Patients
Jean-Luc C. Mougeot, Micaela F. Beckman, Holden C. Langdon, Rajesh V. Lalla, Michael T. Brennan, Farah K. Bahrani Mougeot
Frontiers in Microbiology.2022;[Epub] CrossRef
Therapeutic DNA Vaccines against HPV-Related Malignancies: Promising Leads from Clinical Trials
Jianming Tang, Mingzhu Li, Chao Zhao, Danhua Shen, Lei Liu, Xiujun Zhang, Lihui Wei
Viruses.2022; 14(2): 239. CrossRef
Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming
Stefanie Koster, Rajendra Kumar Gurumurthy, Naveen Kumar, Pon Ganish Prakash, Jayabhuvaneshwari Dhanraj, Sofia Bayer, Hilmar Berger, Shilpa Mary Kurian, Marina Drabkina, Hans-Joachim Mollenkopf, Christian Goosmann, Volker Brinkmann, Zachary Nagel, Mandy M
Nature Communications.2022;[Epub] CrossRef
Peptide-Based Nanovaccines in the Treatment of Cervical Cancer: A Review of Recent Advances
Jiahui Zhang, Jingyi Fan, Mariusz Skwarczynski, Rachel J Stephenson, Istvan Toth, Waleed M Hussein
International Journal of Nanomedicine.2022; Volume 17: 869. CrossRef
Cancer Therapy With TCR-Engineered T Cells: Current Strategies, Challenges, and Prospects
Paul Shafer, Lauren M. Kelly, Valentina Hoyos
Frontiers in Immunology.2022;[Epub] CrossRef
Human Papillomavirus E6/E7 oncogene transcripts as biomarkers for the early detection of cervical cancer
Sadhana M Gupta, Himangi Warke, Hemangi Chaudhari, Padmaja Mavani, Rajshree D. Katke, Shilpa C. Kerkar, Jayanti Mania‐Pramanik
Journal of Medical Virology.2022; 94(7): 3368. CrossRef
Targeting metabolism: A potential strategy for hematological cancer therapy
Xue Tang, Fen Chen, Li-Chun Xie, Si-Xi Liu, Hui-Rong Mai
World Journal of Clinical Cases.2022; 10(10): 2990. CrossRef
Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia
Tafadzwa Chihanga, Sara Vicente-Muñoz, Sonya Ruiz-Torres, Bidisha Pal, Mathieu Sertorio, Paul R. Andreassen, Ruby Khoury, Parinda Mehta, Stella M. Davies, Andrew N. Lane, Lindsey E. Romick-Rosendale, Susanne I. Wells
Cancers.2022; 14(8): 2040. CrossRef
Current and future direction in treatment of HPV-related cervical disease
Niloofar Khairkhah, Azam Bolhassani, Reza Najafipour
Journal of Molecular Medicine.2022; 100(6): 829. CrossRef
Parent Attitudes regarding Orthodontists’ Role as Potential Administrators of Human Papilloma Virus (HPV) Vaccines
Gloria Lee, Jessica Begley, Kavita Ahluwalia, Jaffer A Shariff, Sunil Wadhwa, Christine O’Hea, Gaetano Isola
International Journal of Dentistry.2022; 2022: 1. CrossRef
Graphene Quantum Dots – Hydrothermal Green Synthesis, Material Characterization and Prospects for Cervical Cancer Diagnosis Applications: A Review
Raghavv Raghavender Suresh, Arockia Jayalatha Kulandaisamy, Noel Nesakumar, Saisubramanian Nagarajan, Jung Heon Lee, John Bosco Balaguru Rayappan
ChemistrySelect.2022;[Epub] CrossRef
Interplay between cellular metabolism and DNA viruses
Milad Zandi, Somayeh Shokri, Shahab Mahmoudvand, Ahmad Hosseinzadeh Adli, Ramin Mohammadi, Azita Haddadi
Journal of Medical Virology.2022; 94(11): 5163. CrossRef
Breast Cancer Risk and Human Papillomavirus Infection: A Bradford Hill Criteria Based Evaluation
Muhammad Usman, Yasir Hameed, Mukhtiar Ahmad, Jalil Ur Rehman, Hamad Ahmed, Muhammad Safdar Hussain, Rizwan Asif, Muhammad Ghulam Murtaza, Muhammad Tayyab Jawad, Muhammad Junaid Iqbal
Infectious Disorders - Drug Targets.2022;[Epub] CrossRef
Sensor detection in gynaecological medicine
Michael Thompson, Soha Ahmadi, Katharina Davoudian, Brian De La Franier, Navina Lotay, Marcus Q. Bernardini
Sensors & Diagnostics.2022; 1(5): 877. CrossRef
Cervical cancer screening, treatment and prophylaxis in Brazil: Current and future perspectives for cervical cancer elimination
Flávia M. Corrêa, Arn Migowski, Liz M. de Almeida, Marcelo A. Soares
Frontiers in Medicine.2022;[Epub] CrossRef
HPV-mediated Cervical Cancer: A Systematic Review on Immunological Basis, Molecular Biology, and Immune Evasion Mechanisms
Ramar Vanajothi, Natarajan Srikanth, Rajendran Vijayakumar, Manikandan Palanisamy, Sundaresan Bhavaniramya, Kumpati Premkumar
Current Drug Targets.2022; 23(8): 782. CrossRef
Potential role of human papillomavirus proteins associated with the development of cancer
Dhanvee Balaji, Iyshwarya Bhaskar Kalarani, Vajagathali Mohammed, Ramakrishnan Veerabathiran
VirusDisease.2022; 33(3): 322. CrossRef
Proton-induced DNA damage promotes integration of foreign plasmid DNA into human genome
Meghri Katerji, Antonella Bertucci, Valery Filippov, Marcelo Vazquez, Xin Chen, Penelope J. Duerksen-Hughes
Frontiers in Oncology.2022;[Epub] CrossRef
Anti-cancer properties of Caulerpa racemosa by altering expression of Bcl-2, BAX, cleaved caspase 3 and apoptosis in HeLa cancer cell culture
Happy Kurnia Permatasari, Defny Silvia Wewengkang, Nur Iedha Tertiana, Farida Zharfani Muslim, Muhammad Yusuf, Shintya Octaviana Baliulina, Vanessa Pradna Adyana Daud, Aurielle Annalicia Setiawan, Fahrul Nurkolis
Frontiers in Oncology.2022;[Epub] CrossRef
Does Lactobacillus Exert a Protective Effect on the Development of Cervical and Endometrial Cancer in Women?
Karolina Frąszczak, Bartłomiej Barczyński, Adrianna Kondracka
Cancers.2022; 14(19): 4909. CrossRef
Cervical cancer screening: Past, present and outlook
Radomir Živadinović, Aleksandra Petrić, Aleksandar Živadinović, Sonja Pop-Trajković, Lazar Živadinović, Dušan Simić
Glasnik javnog zdravlja.2022; 96(3): 333. CrossRef
HPV-18 E7 Interacts with Elk-1 Leading to Elevation of the Transcriptional Activity of Elk-1 in Cervical Cancer
Sung-Ho Go, Seung Bae Rho, Dong-Wha Yang, Boh-Ram Kim, Chang Hoon Lee, Seung-Hoon Lee
Biomolecules & Therapeutics.2022; 30(6): 593. CrossRef
A Reverse Structure-based Design of HPV E7 Inhibitor
Wan Chein Tan, Shatrah Othman, See Khai Lim, Nurshamimi Nor Rashid, Choon Han Heh
Current Computer-Aided Drug Design.2022; 18(4): 318. CrossRef
Investigation of Curcumin-Loaded OA400 Nanoparticle’s Effect on the Expression of E6 and E7 Human Papilloma-Virus Oncogenes and P53 and Rb Factors in HeLa Cell Line
Rezvaneh Vahedian Sadeghi, Masoud Parsania, Majid Sadeghizadeh, Setareh Haghighat
Iranian Journal of Pharmaceutical Research.2022;[Epub] CrossRef
Enhancing the Effect of Nucleic Acid Vaccines in the Treatment of HPV-Related Cancers: An Overview of Delivery Systems
Ingrid Andrêssa de Moura, Anna Jéssica Duarte Silva, Larissa Silva de Macêdo, Maria da Conceição Viana Invenção, Mylenna Máyra Gois de Sousa, Antonio Carlos de Freitas
Pathogens.2022; 11(12): 1444. CrossRef
Effects of Human Papilloma Virus E6/E7 Oncoproteins on Genomic Structure in Head and Neck Squamous Cell Carcinoma
Matthew Uzelac, Armon Barakchi, Varsha Beldona, Daniel John, Jaideep Chakladar, Wei Tse Li, Weg M. Ongkeko
Cancers.2022; 14(24): 6190. CrossRef
Towards Novel Gene and Cell Therapy Approaches for Cervical Cancer
Robert Polten, Ivana Kutle, Jens Hachenberg, Rüdiger Klapdor, Michael Morgan, Axel Schambach
Cancers.2022; 15(1): 263. CrossRef
The Presence of Human Papillomavirus and Epstein-Barr Virus Infection in Gastric Cancer: A Systematic Study
Abolfazl Jafari-Sales, Afsoon Shariat, Hossein Bannazadeh Baghi, Behzad Baradaran, Behboud Jafari
Oncologie.2022; 24(3): 413. CrossRef
Immunology of HPV-mediated cervical cancer: current understanding
Babban Jee, Renu Yadav, Sangeeta Pankaj, Shivendra Kumar Shahi
International Reviews of Immunology.2021; 40(5): 359. CrossRef
The role of human papillomavirus in the pathogenesis of sinonasal inverted papilloma: a narrative review
Rohit Gupta, Peter L. Rady, Andrew G. Sikora, Stephen K. Tyring
Reviews in Medical Virology.2021;[Epub] CrossRef
The role of HPV gene expression and selected cellular MiRNAs in lung cancer development
Bashdar Mahmud Hussen, Gelavizh Ahmadi, Havva Marzban, Maryam Ebadi Fard Azar, Saba Sorayyayi, Romina Karampour, Javid Sadri Nahand, Hazha Jamal Hidayat, Mohsen Moghoofei
Microbial Pathogenesis.2021; 150: 104692. CrossRef
Adjunctive testing by cytology, p16/Ki‐67 dual‐stained cytology or HPV16/18 E6 oncoprotein for the management of HPV16/18 screen‐positive women
Leticia Torres‐Ibarra, Attila T. Lorincz, Cosette M. Wheeler, Jack Cuzick, Rubí Hernández‐López, Donna Spiegelman, Leith León‐Maldonado, Berenice Rivera‐Paredez, Pablo Méndez‐Hernández, Eduardo Lazcano‐Ponce, Jorge Salmerón
International Journal of Cancer.2021; 148(9): 2264. CrossRef
EGFR Protein Expression Relates with Tumor Histology, Methylation Status of EGFR and HPV16 E6 Viral Load in Oropharyngeal Carcinoma
Yo Suzuki, Yuki Fukumura, Miki Asahina, Mitsuhisa Fujimaki, Shinichi Ohba, Fumihiko Matsumoto, Isao Kurahayashi, Takashi Yao, Katsuhisa Ikeda
Head and Neck Pathology.2021; 15(3): 743. CrossRef
An internal class III PDZ binding motif in HPV16 E6* protein is required for Dlg degradation activity
Wareerat Umnajvijit, Jariya Sangthong, Fabien Loison, Kulthida Vaeteewoottacharn, Mathurose Ponglikitmongkol
Biochimica et Biophysica Acta (BBA) - General Subjects.2021; 1865(5): 129850. CrossRef
Microbiota Effects on Carcinogenesis: Initiation, Promotion, and Progression
Lacey R. Lopez, Rachel M. Bleich, Janelle C. Arthur
Annual Review of Medicine.2021; 72(1): 243. CrossRef
Ovulatory Follicular Fluid Facilitates the Full Transformation Process for the Development of High-Grade Serous Carcinoma
Che-Fang Hsu, Pao-Chu Chen, Vaishnavi Seenan, Dah-Ching Ding, Tang-Yuan Chu
Cancers.2021; 13(3): 468. CrossRef
Is There a Carcinogenic Risk Attached to Vitamin B12 Deficient Diets and What Should We Do About It? Reviewing the Facts
Alexandra K. Loedin, Dave Speijer
Molecular Nutrition & Food Research.2021;[Epub] CrossRef
Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers
Saghi Nooraei, Howra Bahrulolum, Zakieh Sadat Hoseini, Camellia Katalani, Abbas Hajizade, Andrew J. Easton, Gholamreza Ahmadian
Journal of Nanobiotechnology.2021;[Epub] CrossRef
Focus on HPV Infection and the Molecular Mechanisms of Oral Carcinogenesis
Luigi Santacroce, Michele Di Cosola, Lucrezia Bottalico, Skender Topi, Ioannis Alexandros Charitos, Andrea Ballini, Francesco Inchingolo, Angela Pia Cazzolla, Gianna Dipalma
Viruses.2021; 13(4): 559. CrossRef
An Emerging Anti-p16 Antibody-BC42 Clone as an Alternative to the Current E6H4 for Use in the Female Genital Tract Pathological Diagnosis: Our Experience and a Review on p16ink4a Functional Significance, Role in Daily-Practice Diagnosis, Prognostic Potent
Giuseppe Angelico, Angela Santoro, Frediano Inzani, Patrizia Straccia, Saveria Spadola, Damiano Arciuolo, Michele Valente, Nicoletta D’Alessandris, Roberta Benvenuto, Antonio Travaglino, Antonio Raffone, Gian Franco Zannoni
Diagnostics.2021; 11(4): 713. CrossRef
Dynamic crosstalk within the tumor microenvironment of uterine cervical carcinoma: baseline network, iatrogenic alterations, and translational implications
Rosalba De Nola, Vera Loizzi, Ettore Cicinelli, Gennaro Cormio
Critical Reviews in Oncology/Hematology.2021; 162: 103343. CrossRef
Meet the Insidious Players: Review of Viral Infections in Head and Neck Cancer Etiology with an Update on Clinical Trials
Lejla Mahmutović, Esma Bilajac, Altijana Hromić-Jahjefendić
Microorganisms.2021; 9(5): 1001. CrossRef
Degradation of p53 by HPV16-E6 variants isolated from cervical cancer specimens of Moroccan women
Khaoula HADAMI, Charles SABY, Nadia DAKKA, Guillaume COLLIN, Mohammed ATTALEB, Meriem KHYATTI, Abdelkarim FILALI-MALTOUF, Hamid MORJANI, Mohammed EL MZIBRI
Gene.2021; 791: 145709. CrossRef
The potential applications of T cell receptor (TCR)-like antibody in cervical cancer immunotherapy
Sylvia Annabel Dass, Rehasri Selva Rajan, Gee Jun Tye, Venugopal Balakrishnan
Human Vaccines & Immunotherapeutics.2021; 17(9): 2981. CrossRef
UVB Inhibits Proliferation, Cell Cycle and Induces Apoptosis via p53, E2F1 and Microtubules System in Cervical Cancer Cell Lines
Angelica Judith Granados-López, Eduardo Manzanares-Acuña, Yamilé López-Hernández, Julio Enrique Castañeda-Delgado, Ixamail Fraire-Soto, Claudia Araceli Reyes-Estrada, Rosalinda Gutiérrez-Hernández, Jesús Adrián López
International Journal of Molecular Sciences.2021; 22(10): 5197. CrossRef
Novel Affibody Molecules Targeting the HPV16 E6 Oncoprotein Inhibited the Proliferation of Cervical Cancer Cells
Jinshun Zhu, Saidu Kamara, Qi Wang, Yanru Guo, Qingfeng Li, Linlin Wang, Jingjing Chen, Qianqian Du, Wangqi Du, Shao Chen, Shanli Zhu, Jun Chen, Maoping Chu, Lifang Zhang
Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef
Recent Progress in Electrochemical Detection of Human Papillomavirus (HPV) via Graphene‐Based Nanosensors
Seyyed Mojtaba Mousavi, Gity Behbudi, Seyyed Alireza Hashemi, Aziz Babapoor, Wei-Hung Chiang, Seeram Ramakrishna, Mohammed Muzibur Rahman, Chin Wei Lai, Ahmad Gholami, Navid Omidifar, Khadije Yousefi, Bruno C. Janegitz
Journal of Sensors.2021;[Epub] CrossRef
Antioxidants Associated With Oncogenic Human Papillomavirus Infection in Women
Hui-Yi Lin, Qiufan Fu, Yu-Hsiang Kao, Tung-sung Tseng, Krzysztof Reiss, Jennifer E Cameron, Martin J Ronis, Joseph Su, Navya Nair, Hsiao-Man Chang, Michael E Hagensee
The Journal of Infectious Diseases.2021; 224(9): 1520. CrossRef
The Microbiome and Gynecologic Cancer: Current Evidence and Future Opportunities
Laura M. Chambers, Parker Bussies, Roberto Vargas, Emily Esakov, Surabhi Tewari, Ofer Reizes, Chad Michener
Current Oncology Reports.2021;[Epub] CrossRef
Interpretations on the Interaction between Protein Tyrosine Phosphatase and E7 Oncoproteins of High and Low-Risk HPV: A Computational Perception
Murali Aarthy, Sanjeev Kumar Singh
ACS Omega.2021; 6(25): 16472. CrossRef
Validation of Potential Protein Markers Predicting Chemoradioresistance in Early Cervical Cancer by Immunohistochemistry
Soo Young Jeong, Joon-Yong Chung, Sun-Ju Byeon, Chul Jung Kim, Yoo-Young Lee, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Ye Lin Chae, So Young Oh, Chel Hun Choi
Frontiers in Oncology.2021;[Epub] CrossRef
Viral load and interaction of HPV oncoprotein E6 and E7 with host cellular markers in the progression of cervical cancer
Bilal Ahmad Mir, P. F. Rahaman, Arif Ahmad
AIMS Molecular Science.2021; 8(3): 184. CrossRef
Integrin alpha 6 as a stemness driver is a novel promising target for HPV (+) head and neck squamous cell carcinoma
Jin Seol An, Jung Hwa Moon, Chayeon Kim, Joo Kyung No, Young Gyu Eun, Young Chang Lim
Experimental Cell Research.2021; 407(2): 112815. CrossRef
Reduced MAGI3 level by HPV18E6 contributes to Wnt/β‐catenin signaling activation and cervical cancer progression
Zhuoli Yang, Hua Liu, Ran Song, Wenxiu Lu, Haibo Wang, Siyu Gu, Xuedi Cao, Yibin Chen, Jihuan Liang, Qiong Qin, Xiaomei Yang, Duiping Feng, Junqi He
FEBS Open Bio.2021; 11(11): 3051. CrossRef
An Integrated View of Virus-Triggered Cellular Plasticity Using Boolean Networks
Jenny Paola Alfaro-García, María Camila Granados-Alzate, Miguel Vicente-Manzanares, Juan Carlos Gallego-Gómez
Cells.2021; 10(11): 2863. CrossRef
Role of interleukin-17 in human papillomavirus infection and associated malignancies
Utkarsha Sahu, Prashant Khare
Microbial Pathogenesis.2021; 161: 105294. CrossRef
FNDC3B and BPGM Are Involved in Human Papillomavirus-Mediated Carcinogenesis of Cervical Cancer
Luhan Zhang, Hong Yu, Tian Deng, Li Ling, Juan Wen, Mingfen Lv, Rongying Ou, Qiaozhi Wang, Yunsheng Xu
Frontiers in Oncology.2021;[Epub] CrossRef
Investigating host-virus interaction mechanism and phylogenetic analysis of viral proteins involved in the pathogenesis
Ahmad Abu Turab Naqvi, Farah Anjum, Alaa Shafie, Sufian Badar, Abdelbaset Mohamed Elasbali, Dharmendra Kumar Yadav, Md. Imtaiyaz Hassan, Timir Tripathi
PLOS ONE.2021; 16(12): e0261497. CrossRef
Potential anticancer effect of aspirin and 2'‑hydroxy‑2,3,5'‑trimethoxychalcone‑linked polymeric micelles against cervical cancer through apoptosis
Kang Lee, Suji Baek, Myeong Yoon, Ji Park, Bok Hong, Sang Lee, Seung Oh, Seung Kwon, Ruda Lee, Dae Lee, Kang-Seo Park, Byung Moon
Oncology Letters.2021;[Epub] CrossRef
HPVE6-USP46 Mediated Cdt2 Stabilization Reduces Set8 Mediated H4K20-Methylation to Induce Gene Expression Changes
Shashi Kiran, Briana Wilson, Shekhar Saha, Julia Ann Graff, Anindya Dutta
Cancers.2021; 14(1): 30. CrossRef
Translatable gene therapy for lung cancer using Crispr CAS9—an exploratory review
Jishnu Nair, Abhishek Nair, Soundaram Veerappan, Dwaipayan Sen
Cancer Gene Therapy.2020; 27(3-4): 116. CrossRef
Cancer signaling by plasmonic quantum probes
Ayushi Agarwal, Krishnan Venkatakrishnan, Bo Tan
Applied Materials Today.2020; 18: 100465. CrossRef
Multistate Markov Model to Predict the Prognosis of High-Risk Human Papillomavirus-Related Cervical Lesions
Ayumi Taguchi, Konan Hara, Jun Tomio, Kei Kawana, Tomoki Tanaka, Satoshi Baba, Akira Kawata, Satoko Eguchi, Tetsushi Tsuruga, Mayuyo Mori, Katsuyuki Adachi, Takeshi Nagamatsu, Katsutoshi Oda, Toshiharu Yasugi, Yutaka Osuga, Tomoyuki Fujii
Cancers.2020; 12(2): 270. CrossRef
Early-stage cervical cancer diagnosis based on an ultra-sensitive electrochemical DNA nanobiosensor for HPV-18 detection in real samples
Pegah Mahmoodi, Majid Rezayi, Elisa Rasouli, Amir Avan, Mehrdad Gholami, Majid Ghayour Mobarhan, Ehsan Karimi, Yatima Alias
Journal of Nanobiotechnology.2020;[Epub] CrossRef
Cervical Cancer Screening: Past, Present, and Future
Sarah L. Bedell, Lena S. Goldstein, Amelia R. Goldstein, Andrew T. Goldstein
Sexual Medicine Reviews.2020; 8(1): 28. CrossRef
Potential oncogenic roles of mutant-p53-derived exosomes in the tumor–host interaction of head and neck cancers
Etti Ester Azulay, Tomer Cooks, Moshe Elkabets
Cancer Immunology, Immunotherapy.2020; 69(2): 285. CrossRef
Extracellular Vesicles from Human Papilloma Virus-Infected Cervical Cancer Cells Enhance HIV-1 Replication in Differentiated U1 Cell Line
Sabina Ranjit, Sunitha Kodidela, Namita Sinha, Subhash Chauhan, Santosh Kumar
Viruses.2020; 12(2): 239. CrossRef
Preparation, Characterization and Diagnostic Valuation of Two Novel Anti-HPV16 E7 Oncoprotein Monoclonal Antibodies
Renjian Hu, Zhen Dong, Kui Zhang, Guangzhao Pan, Chongyang Li, Hongjuan Cui
Viruses.2020; 12(3): 333. CrossRef
Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics
Patrick Herr, Johan Boström, Eric Rullman, Sean G. Rudd, Mattias Vesterlund, Janne Lehtiö, Thomas Helleday, Gianluca Maddalo, Mikael Altun
Molecular & Cellular Proteomics.2020; 19(4): 608. CrossRef
HPV Infection Significantly Accelerates Glycogen Metabolism in Cervical Cells with Large Nuclei: Raman Microscopic Study with Subcellular Resolution
Katarzyna Sitarz, Krzysztof Czamara, Joanna Bialecka, Malgorzata Klimek, Barbara Zawilinska, Slawa Szostek, Agnieszka Kaczor
International Journal of Molecular Sciences.2020; 21(8): 2667. CrossRef
Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers
Shaian Tavakolian, Hossein Goudarzi, Ebrahim Faghihloo
Infectious Agents and Cancer.2020;[Epub] CrossRef
Oncolytic Newcastle disease virus delivered by Mesenchymal stem cells-engineered system enhances the therapeutic effects altering tumor microenvironment
Mohsen Keshavarz, Mir Saeed Ebrahimzadeh, Seyed Mohammad Miri, Hassan Dianat-Moghadam, Seyedeh Sara Ghorbanhosseini, Seyed Reza Mohebbi, Hossein Keyvani, Amir Ghaemi
Virology Journal.2020;[Epub] CrossRef
Virus-Specific T Cells for the Treatment of Malignancies—Then, Now, and the Future
Sandhya Sharma, Wingchi K Leung, Helen E Heslop
Current Stem Cell Reports.2020; 6(2): 17. CrossRef
The Relationship between Estrogen-Related Signaling and Human Papillomavirus Positive Cancers
Claire D. James, Iain M. Morgan, Molly L. Bristol
Pathogens.2020; 9(5): 403. CrossRef
Combination Vaccination With Tetanus Toxoid and Enhanced Tumor-Cell Based Vaccine Against Cervical Cancer in a Mouse Model
Donia Alson, Scott C. Schuyler, Bo-Xin Yan, Karthika Samimuthu, Jiantai Timothy Qiu
Frontiers in Immunology.2020;[Epub] CrossRef
HPV‐related methylation‐based reclassification and risk stratification of cervical cancer
Si Yang, Ying Wu, Shuqian Wang, Peng Xu, Yujiao Deng, Meng Wang, Kang Liu, Tian Tian, Yuyao Zhu, Na Li, Linghui Zhou, Zhijun Dai, Huafeng Kang
Molecular Oncology.2020; 14(9): 2124. CrossRef
Anti-tumor activities of probiotics in cervical cancer
Moghaddaseh Jahanshahi, Parisa Maleki Dana, Bita Badehnoosh, Zatollah Asemi, Jamal Hallajzadeh, Mohammad Ali Mansournia, Bahman Yousefi, Bahram Moazzami, Shahla Chaichian
Journal of Ovarian Research.2020;[Epub] CrossRef
Dysregulation of Stemness Pathways in HPV Mediated Cervical Malignant Transformation Identifies Potential Oncotherapy Targets
Megha Budhwani, Samuel W. Lukowski, Sandro V. Porceddu, Ian H. Frazer, Janin Chandra
Frontiers in Cellular and Infection Microbiology.2020;[Epub] CrossRef
Bee venom inhibits the proliferation and migration of cervical-cancer cells in an HPV E6/E7-dependent manner
Da-Hyun Kim, Hyun-Woo Lee, Hyun-Woo Park, Han-Woong Lee, Kyung-Hee Chun
BMB Reports.2020; 53(8): 419. CrossRef
The association between HPV gene expression, inflammatory agents and cellular genes involved in EMT in lung cancer tissue
Marzieh Rezaei, Shayan Mostafaei, Amir Aghaei, Nayyerehalsadat Hosseini, Hassan Darabi, Majid Nouri, Ashkan Etemadi, Andrew O’. Neill, Javid Sadri Nahand, Hamed Mirzaei, Seamas C. Donnelly, Mohammad Doroudian, Mohsen Moghoofei
BMC Cancer.2020;[Epub] CrossRef
The role of viruses in adenocarcinoma development
Mohsen Nakhaie, Javad Charostad, Gholam Abbas Kaydani, Ebrahim Faghihloo
Infection, Genetics and Evolution.2020; 86: 104603. CrossRef
Use of Cap Analysis Gene Expression to detect human papillomavirus promoter activity patterns at different disease stages
Ayumi Taguchi, Kazunori Nagasaka, Charles Plessy, Hiroe Nakamura, Yoshiko Kawata, Sachi Kato, Kosuke Hashimoto, Takeshi Nagamatsu, Katsutoshi Oda, Iwao Kukimoto, Kei Kawana, Piero Carninci, Yutaka Osuga, Tomoyuki Fujii
Scientific Reports.2020;[Epub] CrossRef
Potential therapeutic and pharmacological effects of Wogonin: an updated review
Do Luong Huynh, Tran Hoang Ngau, Nguyen Hoai Nguyen, Gia-Buu Tran, Cuong Thach Nguyen
Molecular Biology Reports.2020; 47(12): 9779. CrossRef
The Molecular and Pathophysiological Functions of Members of the LNX/PDZRN E3 Ubiquitin Ligase Family
Jeongkwan Hong, Minho Won, Hyunju Ro
Molecules.2020; 25(24): 5938. CrossRef
Investigating the aetiology of adverse events following HPV vaccination with systems vaccinology
Joan Campbell-Tofte, Aristidis Vrahatis, Knud Josefsen, Jesper Mehlsen, Kaj Winther
Cellular and Molecular Life Sciences.2019; 76(1): 67. CrossRef
DNA methyltransferases in virus‐associated cancers
Javad Charostad, Akram Astani, Hossein Goudarzi, Ebrahim Faghihloo
Reviews in Medical Virology.2019;[Epub] CrossRef
Identification and characterization of an alternative cancer-derived PD-L1 splice variant
Nadia B. Hassounah, Venkat S. Malladi, Yi Huang, Samuel S. Freeman, Ellen M. Beauchamp, Shohei Koyama, Nicholas Souders, Sunil Martin, Glenn Dranoff, Kwok-Kin Wong, Chandra S. Pedamallu, Peter S. Hammerman, Esra A. Akbay
Cancer Immunology, Immunotherapy.2019; 68(3): 407. CrossRef
What is the potential of p53 isoforms as a predictive biomarker in the treatment of cancer?
Liam Hayman, Wajeeh Raza Chaudhry, Victor V. Revin, Nikolai Zhelev, Jean-Christophe Bourdon
Expert Review of Molecular Diagnostics.2019; 19(2): 149. CrossRef
Transforming properties of ovine papillomaviruses E6 and E7 oncogenes
Gessica Tore, Gian Mario Dore, Carla Cacciotto, Rosita Accardi, Antonio G. Anfossi, Luisa Bogliolo, Marco Pittau, Salvatore Pirino, Tiziana Cubeddu, Massimo Tommasino, Alberto Alberti
Veterinary Microbiology.2019; 230: 14. CrossRef
Human papilloma virus and breast cancer: the role of inflammation and viral expressed proteins
Niloofar Khodabandehlou, Shayan Mostafaei, Ashkan Etemadi, Amir Ghasemi, Mehrdad Payandeh, Shima Hadifar, Amir Hossein Norooznezhad, Anoshirvan Kazemnejad, Mohsen Moghoofei
BMC Cancer.2019;[Epub] CrossRef
HPVE6/E7,hTERT, andKi67mRNA RT-qPCR Assay for Detecting High-Grade Cervical Lesion with Microscope Slides
Geehyuk Kim, Jemberu Taye, Kwangmin Yu, Sunyoung Park, Jungho Kim, Sunghyun Kim, Dongsup Lee, Hye-young Wang, Kwang Hwa Park, Hyeyoung Lee
Analytical Cellular Pathology.2019; 2019: 1. CrossRef
A high-risk papillomavirus 18 E7 affibody-enabled in vivo imaging and targeted therapy of cervical cancer
Ledan Wang, Wangqi Du, Shanli Zhu, Pengfei Jiang, Lifang Zhang
Applied Microbiology and Biotechnology.2019; 103(7): 3049. CrossRef
HOXC6 promotes cervical cancer progression via regulation of Bcl‐2
Yongsheng Wang, Cong Wang, Na Liu, Jun Hou, Wenjing Xiao, Hui Wang
The FASEB Journal.2019; 33(3): 3901. CrossRef
Meta‐analysis of the accuracy of p16 or p16/Ki‐67 immunocytochemistry versus HPV testing for the detection of CIN2+/CIN3+ in triage of women with minor abnormal cytology
Eliana Peeters, Nicolas Wentzensen, Christine Bergeron, Marc Arbyn
Cancer Cytopathology.2019; 127(3): 169. CrossRef
Long non-coding RNA FAM83H-AS1 is regulated by human papillomavirus 16 E6 independently of p53 in cervical cancer cells
Jamie A. Barr, Karen E. Hayes, Tayvia Brownmiller, Abby D. Harold, Rajaganapathi Jagannathan, Paul R. Lockman, Saleem Khan, Ivan Martinez
Scientific Reports.2019;[Epub] CrossRef
Pongapin and Karanjin, furanoflavanoids of Pongamia pinnata, induce G2/M arrest and apoptosis in cervical cancer cells by differential reactive oxygen species modulation, DNA damage, and nuclear factor kappa‐light‐chain‐enhancer of activated B cell signal
Rituparna Roy, Debolina Pal, Subhayan Sur, Suvra Mandal, Prosenjit Saha, Chinmay Kumar Panda
Phytotherapy Research.2019; 33(4): 1084. CrossRef
Effect of Multiple Vaccinations with Tumor Cell-Based Vaccine with Codon-Modified GM-CSF on Tumor Growth in a Mouse Model
Jiantai Qiu, Donia Alson, Ta-Hsien Lee, Ching-Chou Tsai, Ting-Wei Yu, Yu-Sing Chen, Ya-Fang Cheng, Chu-Chi Lin, Scott Schuyler
Cancers.2019; 11(3): 368. CrossRef
Flax seed oil reduced tumor growth, modulated immune responses and decreased HPV E6 and E7 oncoprotein expression in a murine model of ectopic cervical cancer
Rashmi Deshpande, Prerna Raina, Kavita Shinde, Prakash Mansara, Manjiri Karandikar, Ruchika Kaul-Ghanekar
Prostaglandins & Other Lipid Mediators.2019; 143: 106332. CrossRef
The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions
Predrag Kukic, Giuseppe Mattia Lo Piccolo, Marcela O. Nogueira, Dmitri I. Svergun, Michele Vendruscolo, Isabella C. Felli, Roberta Pierattelli
Scientific Reports.2019;[Epub] CrossRef
Immune Signature-Based Subtypes of Cervical Squamous Cell Carcinoma Tightly Associated with Human Papillomavirus Type 16 Expression, Molecular Features, and Clinical Outcome
Xiaofan Lu, Liyun Jiang, Liya Zhang, Yue Zhu, Wenjun Hu, Jiashuo Wang, Xinjia Ruan, Zhengbao Xu, Xiaowei Meng, Jun Gao, Xiaoping Su, Fangrong Yan
Neoplasia.2019; 21(6): 591. CrossRef
How to Steer and Control ERK and the ERK Signaling Cascade Exemplified by Looking at Cardiac Insufficiency
Tim Breitenbach, Kristina Lorenz, Thomas Dandekar
International Journal of Molecular Sciences.2019; 20(9): 2179. CrossRef
Dietary Polyphenols, Resveratrol and Pterostilbene Exhibit Antitumor Activity on an HPV E6-Positive Cervical Cancer Model: An in vitro and in vivo Analysis
Kaushiki Chatterjee, Sumit Mukherjee, Jonathan Vanmanen, Probal Banerjee, Jimmie E. Fata
Frontiers in Oncology.2019;[Epub] CrossRef
Human papilloma virus DNA-biomarker analysis for cervical cancer: Signal enhancement by gold nanoparticle-coupled tetravalent streptavidin-biotin strategy
Qingfeng Lv, Yongmei Wang, Cuijin Su, Thangavel Lakshmipriya, Subash C.B. Gopinath, Kannaiyan Pandian, Veeradasan Perumal, Ying Liu
International Journal of Biological Macromolecules.2019; 134: 354. CrossRef
RNA-seq analysis in equine papillomavirus type 2-positive carcinomas identifies affected pathways and potential cancer markers as well as viral gene expression and splicing events
Anna Sophie Ramsauer, Jakub Kubacki, Claude Favrot, Mathias Ackermann, Cornel Fraefel, Kurt Tobler
Journal of General Virology .2019; 100(6): 985. CrossRef
Different expression of GSK3β and pS9GSK3β depending on phenotype of cervical cancer: possible association of GSK3β with squamous cell carcinoma and pS9GSK3β with adenocarcinoma
Kwanghee Ahn, Sojung Kweon, Dae Woon Kim, Hojung Lee
Obstetrics & Gynecology Science.2019; 62(3): 157. CrossRef
Delivery of microRNAs by Extracellular Vesicles in Viral Infections: Could the News be Packaged?
Fabio Seiti Yamada Yoshikawa, Franciane Mouradian Emidio Teixeira, Maria Notomi Sato, Luanda Mara da Silva Oliveira
Cells.2019; 8(6): 611. CrossRef
The high-risk HPV oncogene E7 upregulates miR-182 expression through the TGF-β/Smad pathway in cervical cancer
Jiao Chen, Yan Deng, Liangfei Ao, Yi Song, Yan Xu, Chi Chiu Wang, Kwong Wai Choy, Kwok Hung Tony Chung, Quan Du, Yi Sui, Tao Yang, Jing Yang, Hu Li, Chang Zou, Tao Tang
Cancer Letters.2019; 460: 75. CrossRef
A unique insert in the genomes of high-risk human papillomaviruses with a predicted dual role in conferring oncogenic risk
Noam Auslander, Yuri I. Wolf, Svetlana A. Shabalina, Eugene V. Koonin
F1000Research.2019; 8: 1000. CrossRef
Papillomavirus DNA not detected in canine lobular orbital adenoma and normal conjunctival tissue
Elizabeth A. F. Schaefer, Shirley Chu, Jacqueline W. Pearce, Jeffrey N. Bryan, Brian K. Flesner
BMC Veterinary Research.2019;[Epub] CrossRef
Phenotype-based discovery of a HeLa-specific cytotoxic molecule that downregulates HPV-mediated signaling pathwaysviaoxidative damage
Sanghee Lee, Wansang Cho, Sungyoul Hong, Sihyeong Yi, Heejun Kim, Soo Yeon Baek, Hankum Park, Jinjoo Jung, Young Kee Shin, Seung Bum Park
Organic & Biomolecular Chemistry.2019; 17(31): 7388. CrossRef
High Incidence of Human Papillomavirus Types 16 and 18 in Cervical Carcinoma Patients in a Tertiary Care Unit, Jabalpur, MP, India
Shyamji Rawat, Sulekha Yadav, Pranjil Mandloi, Chinkal Panihar, P. V. Barde
Indian Journal of Gynecologic Oncology.2019;[Epub] CrossRef
Advances in technologies for cervical cancer detection in low-resource settings
Kathryn A. Kundrod, Chelsey A. Smith, Brady Hunt, Richard A. Schwarz, Kathleen Schmeler, Rebecca Richards-Kortum
Expert Review of Molecular Diagnostics.2019; 19(8): 695. CrossRef
Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System
Chenhao Zhou, Zewen Kelvin Tuong, Ian Hector Frazer
Frontiers in Oncology.2019;[Epub] CrossRef
Identification of potential binding pocket on viral oncoprotein HPV16 E6: a promising anti-cancer target for small molecule drug discovery
Srikanth Kolluru, Rosemary Momoh, Lydia Lin, Jayapal Reddy Mallareddy, John L. Krstenansky
BMC Molecular and Cell Biology.2019;[Epub] CrossRef
The DNA deaminase APOBEC3B interacts with the cell-cycle protein CDK4 and disrupts CDK4-mediated nuclear import of Cyclin D1
Jennifer L. McCann, Madeline M. Klein, Evelyn M. Leland, Emily K. Law, William L. Brown, Daniel J. Salamango, Reuben S. Harris
Journal of Biological Chemistry.2019; 294(32): 12099. CrossRef
LncRNA SRA1 is down-regulated in HPV-negative cervical squamous cell carcinoma and regulates cancer cell behaviors
Yunyong Liu, Mengdan Li, Huihui Yu, Haozhe Piao
Bioscience Reports.2019;[Epub] CrossRef
Diagnosis and management of vulvar cancer: A review
Andrea Tan, Amy K. Bieber, Jennifer A. Stein, Miriam K. Pomeranz
Journal of the American Academy of Dermatology.2019; 81(6): 1387. CrossRef
Transcription factor homeobox D9 is involved in the malignant phenotype of cervical cancer through direct binding to the human papillomavirus oncogene promoter
Nobumaru Hirao, Takashi Iwata, Kohsei Tanaka, Hiroshi Nishio, Masaru Nakamura, Tohru Morisada, Kenji Morii, Natsuki Maruyama, Yuki Katoh, Tomonori Yaguchi, Shigeki Ohta, Iwao Kukimoto, Daisuke Aoki, Yutaka Kawakami
Gynecologic Oncology.2019; 155(2): 340. CrossRef
Phase 1 Safety and Immunogenicity Trial of Recombinant Lactococcus lactis Expressing Human Papillomavirus Type 16 E6 Oncoprotein Vaccine
Sedigheh Taghinezhad-S, Amir Hossein Mohseni, Hossein Keyvani, Mohammad Reza Razavi
Molecular Therapy - Methods & Clinical Development.2019; 15: 40. CrossRef
Cloning and expression of the L1 immunogenic protein of human papillomavirus genotype 16 by using Lactobacillus expression system
Masumeh Haj Hodaei, Rudabeh Behzadi Anduhjerdi, Jalil Fallah Mehrabadi, Davoud Esmaeili
Gene Reports.2019; 17: 100521. CrossRef
Relationship between p16 expression and prognosis in different anatomic subsites of OSCC
Yanhong Ni, Xiaoxin Zhang, Yunxia Wan, Kai Dun Tang, Yin Xiao, Yue Jing, Yuxian Song, Xiaofeng Huang, Chamindie Punyadeera, Qingang Hu
Cancer Biomarkers.2019; 26(3): 375. CrossRef
A unique insert in the genomes of high-risk human papillomaviruses with a predicted dual role in conferring oncogenic risk
Noam Auslander, Yuri I. Wolf, Svetlana A. Shabalina, Eugene V. Koonin
F1000Research.2019; 8: 1000. CrossRef
A Current Update on Human Papillomavirus-Associated Head and Neck Cancers
Ebenezer Tumban
Viruses.2019; 11(10): 922. CrossRef
Current Perspectives in Human Papilloma Virus: Where We are and What We Need?
B.S Anjali Devi, Venugopal Reddy Bovilla, SubbaRao V. Madhunapantula
Biomedical and Pharmacology Journal.2019; 12(04): 1683. CrossRef
Plant viral and bacteriophage delivery of nucleic acid therapeutics
Patricia Lam, Nicole F. Steinmetz
WIREs Nanomedicine and Nanobiotechnology.2018;[Epub] CrossRef
Prevalence of human papillomavirus in benign and malignant laryngeal lesions in Egyptian patients: Cross‐sectional study
P. Milad, H. Kassamy, A. Askoura, S. Abuelela, R. Salem, D. Ragab
Clinical Otolaryngology.2018; 43(1): 312. CrossRef
Human papillomavirus E7 induces p63 expression to modulate DNA damage response
Sahar Eldakhakhny, Qing Zhou, Emma J. Crosbie, Berna S. Sayan
Cell Death & Disease.2018;[Epub] CrossRef
ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer
Nam-phuong D Nguyen, Viraj Deshpande, Jens Luebeck, Paul S Mischel, Vineet Bafna
Nucleic Acids Research.2018; 46(7): 3309. CrossRef
Resveratrol and Pterostilbene Exhibit Anticancer Properties Involving the Downregulation of HPV Oncoprotein E6 in Cervical Cancer Cells
Kaushiki Chatterjee, Dina AlSharif, Christina Mazza, Palwasha Syar, Mohamed Al Sharif, Jimmie E. Fata
Nutrients.2018; 10(2): 243. CrossRef
Use of protein-based biomarkers of exfoliated cervical cells for primary screening of cervical cancer
Yingji Jin, Seung Cheol Kim, Hyoung Jin Kim, Woong Ju, Yun Hwan Kim, Hong-Jin Kim
Archives of Pharmacal Research.2018; 41(4): 438. CrossRef
ARFHPV E7 oncogene, lncRNA HOTAIR, miR‐331‐3p and its target, NRP2, form a negative feedback loop to regulate the apoptosis in the tumorigenesis in HPV positive cervical cancer
Min Zhang, Yinghui Song, Furui Zhai
Journal of Cellular Biochemistry.2018; 119(6): 4397. CrossRef
Lupeol induces S-phase arrest and mitochondria-mediated apoptosis in cervical cancer cells
Nupoor Prasad, Akash Sabarwal, Umesh C S Yadav, Rana P Singh
Journal of Biosciences.2018; 43(2): 249. CrossRef
Deregulated TNF-Alpha Levels Along with HPV Genotype 16 Infection Are Associated with Pathogenesis of Cervical Neoplasia in Northeast Indian Patients
Chandana Ray Das, Diptika Tiwari, Anita Dongre, Mohammad Aasif Khan, Syed Akhtar Husain, Anirudha Sarma, Sujoy Bose, Purabi Deka Bose
Viral Immunology.2018; 31(4): 282. CrossRef
Lactobacillus Mucosal Vaccine Vectors: Immune Responses against Bacterial and Viral Antigens
Jonathan S. LeCureux, Gregg A. Dean, Christopher J. Papasian
mSphere.2018;[Epub] CrossRef
SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer‐related phenotypes
Viviana E. Hermosilla, Ginessa Salgado, Elizabeth Riffo, David Escobar, Matías I. Hepp, Carlos Farkas, Mario Galindo, Violeta Morín, María A. García‐Robles, Ariel F. Castro, Roxana Pincheira
Molecular Oncology.2018; 12(7): 1026. CrossRef
The combinational effect of E6/E7 siRNA and anti-miR-182 on apoptosis induction in HPV16-positive cervical cells
Hamidreza Javadi, Abbas Sahebghadam Lotfi, Saman Hosseinkhani, Hossein Mehrani, Jafar Amani, Zahra Soheila Soheili, Zahra Hojati, Mehdi Kamali
Artificial Cells, Nanomedicine, and Biotechnology.2018; 46(sup2): 727. CrossRef
A Cu2+ complex induces the aggregation of human papillomavirus oncoprotein E6 and stabilizes p53
Amit Kumar, Lars T. Kuhn, Jochen Balbach
The FEBS Journal.2018; 285(16): 3013. CrossRef
The Myb-related protein MYPOP is a novel intrinsic host restriction factor of oncogenic human papillomaviruses
Elena Wüstenhagen, Fatima Boukhallouk, Inka Negwer, Krishnaraj Rajalingam, Frank Stubenrauch, Luise Florin
Oncogene.2018; 37(48): 6275. CrossRef
Targeting Cyclin-Dependent Kinases for Treatment of Gynecologic Cancers
Z. Ping Lin, Yong-Lian Zhu, Elena S. Ratner
Frontiers in Oncology.2018;[Epub] CrossRef
Development and validation of a multiplex reverse transcript real-time PCR for E6/E7 mRNA detection of high-risk human papillomavirus
Caixia Pan, Jing Zhou, Jiangfeng Lyu, Xuyi Ren
Journal of Medical Microbiology.2018; 67(10): 1509. CrossRef
High-affinity binding with specific peptides endows EuW10a good luminescence probe for HPV E6 detection
Yuxue Liu, Xinxin Yuan, Weixian Wang, Yuqing Wu, Lixin Wu
New Journal of Chemistry.2018; 42(21): 17339. CrossRef
Human papillomavirus type 16 E6 and E7 oncoproteins interact with the nuclear p53-binding protein 1 in an in vitro reconstructed 3D epithelium: new insights for the virus-induced DNA damage response
Diletta Francesca Squarzanti, Rita Sorrentino, Manuela Miriam Landini, Andrea Chiesa, Sabrina Pinato, Francesca Rocchio, Martina Mattii, Lorenza Penengo, Barbara Azzimonti
Virology Journal.2018;[Epub] CrossRef
Do Human Papilloma Viruses Play a Role in the Genesis of Cutaneous Malignancies?
Mohamed JEMF Mabruk
Journal of Dermatology & Cosmetology.2018;[Epub] CrossRef
Nicotinic acetylcholine receptor gene polymorphism is not associated with tobacco-related oral squamous cell carcinoma
Deepa Rajesh, SM Azeem Mohiyuddin, Sharath Balakrishna, AV Moideen Kutty
Indian Journal of Cancer.2018; 55(4): 399. CrossRef
Immune Checkpoint Inhibition in the Treatment of Gynecologic Cancer
Kristen Anderson, Ramez N. Eskander
Current Obstetrics and Gynecology Reports.2018; 7(1): 6. CrossRef
Identification of fatal outcome in a childhood nasopharyngeal carcinoma patient by protein expression profiling
Mohamed Saeed, Rolf Mertens, Rupert Handgretinger, Thomas Efferth
International Journal of Oncology.2018;[Epub] CrossRef
Integration of Oncogenes via Sleeping Beauty as a Mouse Model of HPV16+ Oral Tumors and Immunologic Control
Yi-Hsin Lin, Ming-Chieh Yang, Ssu-Hsueh Tseng, Rosie Jiang, Andrew Yang, Emily Farmer, Shiwen Peng, Talia Henkle, Yung-Nien Chang, Chien-Fu Hung, T.-C. Wu
Cancer Immunology Research.2018; 6(3): 305. CrossRef
Attenuated TRAF3 Fosters Activation of Alternative NF-κB and Reduced Expression of Antiviral Interferon, TP53, and RB to Promote HPV-Positive Head and Neck Cancers
Jialing Zhang, Tony Chen, Xinping Yang, Hui Cheng, Stephan S. Späth, Paul E. Clavijo, Jianhong Chen, Christopher Silvin, Natalia Issaeva, Xiulan Su, Wendell G. Yarbrough, Christina M. Annunziata, Zhong Chen, Carter Van Waes
Cancer Research.2018; 78(16): 4613. CrossRef
Relevant Allelic Frequency of Gene Polymorphism and Genetic Predisposition of Human Papillomavirus in Patients with Cervical Cancer
Nikta Sajjadi, Reza Mirnejad, Malike Sharif, Vahhab Piranfar, Davood Zaeifi
Modern Medical Laboratory Journal.2018; 1(2): 50. CrossRef
Epidemiology and biology of cutaneous human papillomavirus
Emily M Nunes, Valéria Talpe-Nunes, Laura Sichero
Clinics.2018; 73: e489s. CrossRef
Genome characterization of a bovine papillomavirus type 5 from cattle in the Amazon region, Brazil
Flavio R. C. da Silva, Cíntia Daudt, Samuel P. Cibulski, Matheus N. Weber, Ana Paula M. Varela, Fabiana Q. Mayer, Paulo M. Roehe, Cláudio W. Canal
Virus Genes.2017; 53(1): 130. CrossRef
Exploring the potential of genome editing CRISPR-Cas9 technology
Vijai Singh, Darren Braddick, Pawan Kumar Dhar
Gene.2017; 599: 1. CrossRef
Two-step chromatographic purification of glutathione S-transferase-tagged human papillomavirus type 16 E6 protein and its application for serology
Mei Ling Xu, Seung Cheol Kim, Hyoung Jin Kim, Woong Ju, Yun Hwan Kim, Hong-Jin Kim
Protein Expression and Purification.2017; 132: 19. CrossRef
Combining Oncolytic Virotherapy with p53 Tumor Suppressor Gene Therapy
Christian Bressy, Eric Hastie, Valery Z. Grdzelishvili
Molecular Therapy - Oncolytics.2017; 5: 20. CrossRef
MiR-23b controls ALDH1A1 expression in cervical cancer stem cells
Weiwen Wang, Yang Li, Na Liu, Yu Gao, Long Li
BMC Cancer.2017;[Epub] CrossRef
Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit
Daniel Henry Marks, Rozario Thomas, Yvette Chin, Riddhi Shah, Christine Khoo, Robert Benezra
Cell Reports.2017; 19(9): 1832. CrossRef
Genomic abnormalities in invasive endocervical adenocarcinoma correlate with pattern of invasion: biologic and clinical implications
Anjelica Hodgson, Yutaka Amemiya, Arun Seth, Matthew Cesari, Bojana Djordjevic, Carlos Parra-Herran
Modern Pathology.2017; 30(11): 1633. CrossRef
Enhancing antitumor immunogenicity of HPV16-E7 DNA vaccine by fusing DNA encoding E7-antigenic peptide to DNA encoding capsid protein L1 of Bovine papillomavirus
Andrew Yang, Shiwen Peng, Emily Farmer, Qi Zeng, Max A. Cheng, Xiaowu Pang, T. -C. Wu, Chien-Fu Hung
Cell & Bioscience.2017;[Epub] CrossRef
Virus like particles as a platform for cancer vaccine development
Hui Kian Ong, Wen Siang Tan, Kok Lian Ho
PeerJ.2017; 5: e4053. CrossRef
Expression of cell cycle-related proteins in oropharyngeal squamous cell carcinoma based on human papilloma virus status
Koudai Tsuchida, Tamotsu Sugai, Noriyuki Uesugi, Kazuyuki Ishida, Kazuto Matsuura, Ikuro Sato, Kiyoto Shiga, Hiroaki Sato
Oncology Reports.2017; 38(2): 908. CrossRef
Correlation of hTERT Expression with Cervical Cytological Abnormalities and Human Papillomavirus Infection
Vjosa A. Zejnullahu, Valon A. Zejnullahu, Slavica Josifovska, Nikola Vukovik, Kiril Pakovski, Sasho Panov
PRILOZI.2017; 38(3): 143. CrossRef
TAT‑mediated si‑hWAPL inhibits the invasion and metastasis of cervical cancer stem cells
Pijun Gong, Chunyan Hu, Xi Zhou, Renxiao Wang, Zhao Duan
Experimental and Therapeutic Medicine.2017;[Epub] CrossRef
Modulation of DNA methylation by human papillomavirus E6 and E7 oncoproteins in cervical cancer (Review)
Prakriti Sen, Pooja Ganguly, Niladri Ganguly
Oncology Letters.2017;[Epub] CrossRef
Decision management in transoral robotic surgery: Indications, individual patient selection, and role in the multidisciplinary treatment for head and neck cancer from a European perspective
Balazs B. Lörincz, Nathan Jowett, Rainald Knecht
Head & Neck.2016;[Epub] CrossRef
The Role of p53 Gene in Cervical Carcinogenesis
Garima, Sulekha Pandey, L. K. Pandey, A. K. Saxena, Nidhi Patel
The Journal of Obstetrics and Gynecology of India.2016; 66(S1): 383. CrossRef
Biological implications and therapeutic significance of DNA methylation regulated genes in cervical cancer
Samatha Bhat, Shama Prasada Kabekkodu, Ashish Noronha, Kapaettu Satyamoorthy
Biochimie.2016; 121: 298. CrossRef
Human papillomavirus integration pattern and demographic, clinical, and survival characteristics of patients with oropharyngeal squamous cell carcinoma
Ming Yann Lim, Kristina R. Dahlstrom, Erich M. Sturgis, Guojun Li
Head & Neck.2016; 38(8): 1139. CrossRef
A Giant Vulvar Mass: A Case Study of Cellular Angiofibroma
Ümit Aydın, Hasan Terzi, Ünal Turkay, Ahmet Tuğrul Eruyar, Ahmet Kale
Case Reports in Obstetrics and Gynecology.2016; 2016: 1. CrossRef
Aptima HR-HPV testing from Diff-Quick-stained fine-needle aspiration smears of oropharyngeal squamous cell carcinoma
Min Han, Cory T. Bernadt, Benjamin Murray, Steven M. Johnson, Jalal B. Jalaly, Telly Garcia, Laura J. Adhikari
Journal of the American Society of Cytopathology.2016; 5(4): 221. CrossRef
Loss of histone variant macroH2A2 expression associates with progression of anal neoplasm
Wan-Hsiang Hu, Katsumi Miyai, Judith C Sporn, Linda Luo, Jean Y J Wang, Bard Cosman, Sonia Ramamoorthy
Journal of Clinical Pathology.2016; 69(7): 627. CrossRef
Targeting HPV‐infected cervical cancer cells with PEGylated liposomes encapsulating siRNA and the role of siRNA complexation with polyethylenimine
Rachel M. Levine, Christina V. Dinh, Michael A. Harris, Efrosini Kokkoli
Bioengineering & Translational Medicine.2016; 1(2): 168. CrossRef
New Strategies for Multimodality Therapy in Treating Locally Advanced Cervix Cancer
Jonathan Verma, Bradley J. Monk, Aaron H. Wolfson
Seminars in Radiation Oncology.2016; 26(4): 344. CrossRef
A Low-Cost HPV Immunochromatographic Assay to Detect High-Grade Cervical Intraepithelial Neoplasia
Vânia Sammartino Mariano, Adriana Tarlá Lorenzi, Cristovam Scapulatempo-Neto, Maíra Degiovani Stein, Julio Cesar Possati Resende, Márcio Antoniazzi, Luisa Lina Villa, José Eduardo Levi, Adhemar Longatto-Filho, José Humberto Tavares Guerreiro Fregnani, Kal
PLOS ONE.2016; 11(10): e0164892. CrossRef
Inhibition of endoplasmic reticulum (ER) stress sensors sensitizes cancer stem-like cells to ER stress-mediated apoptosis
Asaha Fujimoto, Kei Kawana, Ayumi Taguchi, Katsuyuki Adachi, Masakazu Sato, Hiroe Nakamura, Juri Ogishima, Mitsuyo Yoshida, Tomoko Inoue, Haruka Nishida, Kensuke Tomio, Aki Yamashita, Yoko Matsumoto, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, T
Oncotarget.2016; 7(32): 51854. CrossRef
The potential of plants for the production and delivery of human papillomavirus vaccines
Sergio Rosales-Mendoza, Dania O Govea-Alonso
Expert Review of Vaccines.2015; 14(7): 1031. CrossRef
NGS-based approach to determine the presence of HPV and their sites of integration in human cancer genome
P Chandrani, V Kulkarni, P Iyer, P Upadhyay, R Chaubal, P Das, R Mulherkar, R Singh, A Dutt
British Journal of Cancer.2015; 112(12): 1958. CrossRef
An overview of new biomolecular pathways in pathogen-related cancers
Maria Lina Tornesello, Luigi Buonaguro, Franco M Buonaguro
Future Oncology.2015; 11(11): 1625. CrossRef
Cellular angiofibroma in women: a review of the literature
Vincenzo Dario Mandato, Susanna Santagni, Alberto Cavazza, Lorenzo Aguzzoli, Martino Abrate, Giovanni Battista La Sala
Diagnostic Pathology.2015;[Epub] CrossRef
Human papillomavirus and host genetic polymorphisms in carcinogenesis: A systematic review and meta-analysis
Steven Habbous, Vincent Pang, Wei Xu, Eitan Amir, Geoffrey Liu
Journal of Clinical Virology.2014; 61(2): 220. CrossRef
Human papillomavirus therapeutic vaccines: targeting viral antigens as immunotherapy for precancerous disease and cancer
Matthew P Morrow, Jian Yan, Niranjan Y Sardesai
Expert Review of Vaccines.2013; 12(3): 271. CrossRef
ProExC is a novel marker for distinguishing between primary endometrial and endocervical adenocarcinomas
Ghada E. Esheba
Journal of the Egyptian National Cancer Institute.2013; 25(2): 87. CrossRef
Canine distemper virus induces apoptosis in cervical tumor derived cell lines
Helen L Del Puerto, Almir S Martins, Amy Milsted, Elaine M Souza-Fagundes, Gissandra F Braz, Barbara Hissa, Luciana O Andrade, Fabiana Alves, Daniela S Rajão, Rômulo C Leite, Anilton C Vasconcelos
Virology Journal.2011;[Epub] CrossRef

24,194 View
485 Download
267 Crossref

Original Articles

Immunization with Adenoviral Vectors Carrying Recombinant IL-12 and E7 Enhanced the Antitumor Immunity against Human Papillomavirus 16-associated Tumor: Eun-Kyung Park, Young-Wook Kim, Joon-Mo Lee, Sung-Eun NamKoong, Do-Gang Kim, Heung-Jae Chun, Byoung-Don Han, Su-Mi Bae, Hyun-Sun Jin, Jeong-Im Sin, Woong-Shick Ahn; Cancer Res Treat. 2005;37(1):63-70. Published online February 28, 2005; DOI: https://doi.org/10.4143/crt.2005.37.1.63

Abstract PDF PubReader ePub

Purpose

Human papillomavirus (HPV) infection has a significant role in cervical carcinogenesis, and HPV oncoprotein E7 plays an important part in the formation and maintenance of cervical cancer. Interleukin-12 (IL-12) has been reported to induce a cellular immune response, and to suppress the tumor growth and the E7 production. Here we describe the use of adenoviral delivery of the HPV 16 E7 subunit (AdE7) along with adenoviral delivery of IL-12 (AdIL-12) in mice with HPV-associated tumors.

Materials and Methods

Mice were injected with TC-1 cells to establish TC-1 tumor, and then they were immunized with AdIL-12 and/or AdE7 intratumorally. The anti tumor effects induced by AdIL-12 and/or E7 were evaluated by measuring the size of the tumor. E7-specific antibody and INF-γ production in sera, and the T-helper cell proliferative responses were then measured. Cytotoxic T-lymphocyte (CTL) and T cell subset depletion studies were also performed.

Results

Combined AdIL-12 and AdE7 infection at the tumor sites significantly enhanced the antitumor effects more than that of AdIL-12 or AdE7 single infection. This combined infection resulted in regression of the 9 mm sized tumors in 80% of animals as compare to the PBS group. E7-specific antibody and INF-γ production in the sera, and the T-helper cell proliferative responses were significantly higher with coinfection of AdIL-12 and AdE7 than with AdIL-12 or AdE7 alone. CTL response induced by AdIL-12 and AdE7 in the coinjected group suggested that tumor suppression was mediated by mostly CD8+ and only a little by the CD4+ T cells.

Conclusion

IL-12 and E7 application using adenovirus vector showed antitumor immunity effects against TC-1 tumor, and this system could be use in clinical applications for HPV-associated cancer. (ED note: nice abstract.)

Citations

Citations to this article as recorded by

Development of a replication‐deficient adenoviral vector‐based vaccine candidate for the interception of HPV16‐ and HPV18‐induced infections and disease
Selina Khan, Koen Oosterhuis, Kerstin Wunderlich, Evelien M. Bunnik, Melissa Bhaggoe, Satish Boedhoe, Santusha Karia, Renske D.M. Steenbergen, Leontien Bosch, Jan Serroyen, Sarah Janssen, Hanneke Schuitemaker, Jort Vellinga, Gert Scheper, Roland Zahn, Jer
International Journal of Cancer.2017; 141(2): 393. CrossRef
Immune responses and protective efficacy of a recombinant swinepox virus expressing HA1 against swine H1N1 influenza virus in mice and pigs
Jiarong Xu, Dongyan Huang, shichao Liu, Huixing Lin, Haodan Zhu, Bao Liu, Chengping Lu
Vaccine.2012; 30(20): 3119. CrossRef
Immune responses and protection efficacy of a recombinant swinepox virus expressing HA1 against swine H3N2 influenza virus in mice and pigs
Jiarong Xu, Dongyan Huang, Shichao Liu, Huixing Lin, Haodan Zhu, Bao Liu, Chengping Lu
Virus Research.2012; 167(2): 188. CrossRef

8,780 View
37 Download
3 Crossref

Proteome Analysis of Differential Protein Expression in Cervical Cancer Cells after Paclitaxel Treatment: Eun-Kyoung Yim, Jun-Sang Bae, Seung-Bak Lee, Keun-Ho Lee, Chan-Joo Kim, Sung-Eun Namkoong, Soo-Jong Um, Jong-Sup Park; Cancer Res Treat. 2004;36(6):395-399. Published online December 31, 2004; DOI: https://doi.org/10.4143/crt.2004.36.6.395

Abstract PDF PubReader ePub

Purpose

It is well known that infection with HPV (human papillomavirus) is the main cause of cervical cancer and certain types of HPV are recognized as carcinogens. At present, there is little information regarding the antineoplastic mechanism of paclitaxel against cervical carcinoma cells. We thus tried to analyze differential protein expression and antineoplastic mechanism-related proteins after paclitaxel treatment on cervical cancer cells by using a proteomic analysis and to investigate the mechanism of action.

Materials and Methods

Using proteomics analysis including 2-DE and MALDI-TOF-MS, we detected the antineoplastic mechanism-related proteins. Then, we performed western blot analysis for apoptosis- and transformation-related proteins to confirm expression patterns derived from proteome analysis after paclitaxel treatment.

Results

We identified several cellular proteins that are responsive to paclitaxel treatment in HeLa cells using proteomics methods. Paclitaxel treatment elevated mainly apoptosis, immune response and cell cycle check point-related proteins. On the other hand, paclitaxel treatment diminished growth factor/oncogene-related proteins and transcription regulation-related proteins. Also, in the HPV-associated cervical carcinoma cells, paclitaxel demonstrated anti-proliferative activity through the membrane death receptor-mediated apoptotic pathway and the mitochondrial-mediated pathway.

Conclusion

Identification and characterization of functionally modulated proteins involved in anti-cancer regulatory events should lead to a better understanding of the long-term actions of paclitaxel at the molecular level and will contribute to the future development of novel therapeutic drug treatments based upon current therapies.

Citations

Citations to this article as recorded by

Proteomic Analysis of Thermus thermophilus Cells after Treatment with Antimicrobial Peptide
Alexey K. Surin, Anna I. Malykhina, Michail V. Slizen, Alexey P. Kochetov, Mariya Yu. Suvorina, Vadim E. Biryulyov, Sergei Y. Grishin, Oxana V. Galzitskaya
Bacteria.2024; 3(4): 299. CrossRef
Proteomics approaches in cervical cancer: focus on the discovery of biomarkers for diagnosis and drug treatment monitoring
Georgia Kontostathi, Jerome Zoidakis, Nicholas P. Anagnou, Kalliopi I. Pappa, Antonia Vlahou, Manousos Makridakis
Expert Review of Proteomics.2016; 13(8): 731. CrossRef
PKM2 enhances chemosensitivity to cisplatin through interaction with the mTOR pathway in cervical cancer
Haiyan Zhu, Jun Wu, Wenwen Zhang, Hui Luo, Zhaojun Shen, Huihui Cheng, Xueqiong Zhu
Scientific Reports.2016;[Epub] CrossRef
Proteomic Analysis of Anticancer TCMs Targeted at Mitochondria
Yang Wang, Ru-Yuan Yu, Qing-Yu He
Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1. CrossRef
Mass Spectrometry-Based Proteomics in Molecular Diagnostics: Discovery of Cancer Biomarkers Using Tissue Culture
Debasish Paul, Avinash Kumar, Akshada Gajbhiye, Manas K. Santra, Rapole Srikanth
BioMed Research International.2013; 2013: 1. CrossRef
Identification of Cervical Cancer Proteins Associated With Treatment With Paclitaxel and Cisplatin in Patients
Huiling Liu, Yin Han, Ruoran Mi, Ying Zhang, Gang Su, Hailin Wang, Xin Zhou, Xiangwen Liu, Bingdong Zhu
International Journal of Gynecological Cancer.2011; 21(8): 1452. CrossRef
Impact of taxol on dermal papilla cells — A proteomics and bioinformatics analysis
Pei-Hsiu Chen, Chih-Yuan Wang, Ching-Wu Hsia, Ming-Yi Ho, Ann Chen, Min-Jen Tseng, Yung-Fu Wu, Han-Min Chen, Tzu-Hao Huang, Hung-Te Liu, Hao-Ai Shui
Journal of Proteomics.2011; 74(12): 2760. CrossRef

10,681 View
64 Download
7 Crossref

Accelerated Induction of Dysplastic Lesion by TPA in HPV18 URR E6/E7 Gene Expressing Transgenic Mice: Yongil Kwon, Taechul Park, Jongsup Park, Soojong Um, Jauheung Yu, Junmo Lee, Seungeun Namkoong; J Korean Cancer Assoc. 2001;33(1):56-63.

Abstract PDF: PURPOSE
The research of HPV has been severely hampered by the inability to propagate HPVs in culture, particularly those of the mucosotrophic types which produce few virions in vivo. In order to study the regulation of HPV-18 expression in vivo, we constructed transgenic mice and caused cervical neoplasia.
MATERIALS AND METHODS
We investigated whether tetradecanoyl phorbol acetate (TPA) increase the transcriptional activity of the URR in the C33A cervical carcinoma cells or not. And we asked whether chronic exposure of female HPV-18 URR E6/E7 transgenic mice to TPA could render the reproductive tract squamous epithelium permissive for HPV neoplasia.
RESULTS
It was confirmed by RT-PCR that transgene was specifically expressed in epithelial tissues. TPAupregulated the transcriptional activity of the URR in the C33A cervical carcinoma cells. There were diffuse changes on the squamous epithelium in the cervix of the transgenic mice at fifth month following TPA treatment.
CONCLUSION
We established the transgenic mice model which have the ability to reproduce the development of cervical dysplasias. Moreover this animal model will allow preclinical testing of compounds designed to interfere with the actions of the HPV oncogenes or other critical aspects of the cancer phenotype.

3,006 View
17 Download

The Effects of Interferon/Retinoic Acid on Cervical Cancer Cell Lines According to the Mutational Status of HPV-URR: Tae Yeon Kim, Chan Joo Kim, Eun Joo Kim, Tae Chul Park, Sung Eun Namkoong, Jae Gahb Park, Soo Jong Um, Jong Sup Park; J Korean Cancer Assoc. 2000;32(5):884-894.

Abstract PDF: PURPOSE
We investigated the effects of all-trans-retinoic acid (ATRA) and/or interferon-gamma (IFN-gamma) on the growth of various cervical cancer cell lines and HPV E6/E7 expression. The relationships between the functional activities of HPV-URR and the growth inhibition were identified.
MATERIALS AND METHODS
Four groups of cell lines were included; i) with integrated form of HPV-16 DNA (SNU-17, CaSki), ii) episomal form of HPV-16 (SNU-523), iii) integrated form of HPV-18 (SNU-1160, HeLa) and iv) episomal form of HPV-18 (SNU-1245). The promoter activity of HPV-URR was confirmed by transient transfection assay in C33A using the HPV-18 URR-CAT reporter plasmid.
RESULTS
Selective mutation was detected in TEF-1 (transcriptional enhancer factor) binding site in SNU-17, and the activity of URR in SNU-17 was higher than that of the prototype. The proliferation was more inhibited in SNU-17 by IFN-gamma (10 ng/ml) than in SNU-902, CaSki and HeLa. The increase of the HPV-URR activity might play a role in the inhibition of growth by interferon-g. The expression of HPV-16 E6/E7 were significantly decreased by ATRA or IFN-gamma.
CONCLUSION
Point mutation at TEF-1 binding site of SNU-17 was related with the increased transcriptional activity of URR. Mutation in the HPV-URR and alteration of HPV-URR activity in SNU-17 might be related with significant growth suppression by IFN-gamma.

2,554 View
23 Download

Polymorphisms in E6 Gene of Human Papillomavirus Type 16 Found in Cervical Tissues from Korean Women: Jae Weon Kim, Ju Won Roh, Moon Hong Kim, Noh Hyun Park, Yong Sang Song, Soon Beom Kang, Hyo Pyo Lee; J Korean Cancer Assoc. 2000;32(5):875-883.

Abstract PDF: PURPOSE
To examine the distribution of HPV 16 E6 polymorphisms and analyse the possible association between the polymorphisms and cervical cancer development in Korean women.
MATERIALS AND METHODS
Fifty-four cases of uterine cervical tissues containing HPV 16 DNA confirmed by polymerase chain reaction (PCR) from Korean women were subjected to investigate the E6 gene mutations. PCR-amplified products were sequenced by the fluorescent dideoxy ter mination method and the results obtained from sequencing were analysed. And newly designed PASA method was tried to develop rapid test for identification of the most commonly detected variation.
RESULTS
Among the 27 cervical cancer cases, only two (7.4%) was found as a prototype. Among 11 kind of variants identified in total, 4 variants (5 nucleotide sites) which were never reported before has been found, registered firstly to GenBank. The most frequently found variation was D25E, absolutely different from the previous reports from the western country. There was no statistically significant trend for the D25E variation to be more frequently detected in cancerous lesions than in noncancerous lesions. All of the DNA sequencing results observed could be confirmed by PASA method.
CONCLUSION
These results suggest that Korean-specific genetic factors might operate during the cervical carcinogenesis.

2,771 View
20 Download

Comparison of HPV 16 Sequence Variations at Upstream Regulatory Region in the Couples of Patients with Cervical Cancer for Determination of HPV Infectivity: Jae Weon Kim, Yong Sang Song, Hye Won Jeon, No Hyun Park, Soon Beom Kang, Hyo Pyo Lee; J Korean Cancer Assoc. 1999;31(2):403-410.

Abstract PDF: PURPOSE
Although it is now generally accepted that human papillomaviruses (HPVs) are causally related to cervical neoplasia by plentiful epidemioiogic and experimental works, little is known about the direct evidence of sexual transmission of HPV. This study was undertaken to confirm the transmission route and determine the infectivity of HPV by comparison of HPV 16 sequence variations at upstream regulatory region (URR) in the couples of patient with cervical cancer.
MATERIALS AND METHODS
HPV DNAs obtained from genital lesions of forty married couples of patients with cervical cancer were evaluated by polymerase chain reaction (PCR) and PCR-directed sequencing.
RESULTS
HPV 16 was detected in fourteen (63.6%) of twenty-two male consorts whose wives were positive for HPV 16. Of these, six (42.9%) couples demonstrated identical HPV 16 URR variants between patients and male consorts, and eight had mismatching HPV 16 URR sequences. Among six couples showed matching HPV 16 variants, three couples mamed for 10, 19, 25 years respectively carried variant 7728/7779, two couples married for 15 years each carried variant 7728/7762, and one couple married for 18 years carried variant 7728/7797, CONCLUSION: These data suggest that sexual transmission of HPV 16 does occur. A search for more HPV variants in a large cohort is needed to secure high level of precision in molecular epidemiologic study using HPV variant.

2,429 View
15 Download

Integration of HPV and the Antibody Respones to HPV Proteins in Patients with Cervical Cancer: Joon Mo Lee, Seung Jo Kim, Jong Sup Park, Sung Eun Namkoong, Chan Joo Kim, Tae Chul Park, Soo Jong Um; J Korean Cancer Assoc. 1998;30(6):1184-1197.

Abstract PDF: PURPOSE
HPV (human papillomavirus) are known as the major causative agent for development of cervical cancer. High-risk HPVs, especially HPV-16 /18 DNA, are often found to be integrated into the human genome in high grade CINs as well as cervial cancer. Investigation of the relationship between the genomic states of HPV genes and their antibody response against the HPV-16 Ll/L2 virus-like particles (VLPs) and the in vitro translated E6 and E7 proteins may help to explain the mechanism of HPV-related cervical carcinogenesis and host immune responses.
MATERIALS AND METHODS
Cervical cancer tissues obtained from 41 patients with cervical cancer were studied by PCR, Southern blot hybridization and the antibody response against HPV-16 Ll/L2 VLPs and HPV-16 E6, E7 proteins of serum were tested by ELISA and radioimmunoprecipitation assay (RIPA), respectively.
RESULTS
Integrated forms of the HPV-16 DNA were found in 23 of the 38 patients (60.5%). The HPV-16 positive cervial cancer patients had a significantly higher prevalence (39.5%; 15/38) of antibodies to HPV-16 Ll/L2 VLPs than 8.7% (2/28) of the the control group (p<0.05). Antibodies to HPV-16 Ll/L2 VLPs were more detectable in 60% (9/15) of the cervical cancer patients with episomal forms of HPV-16 DNA than those who having only integrated HPV-16 (26.1%; 6/23) (p<0.05). Antibodies to E6 and E7 proteins were positive in 36.8% (14/38) and 50% (19/38) of the patients with HPV-16 positive cervical cancer. And those were siginificantly higher than the positivities for the control group (8.3% and 2.8%), (p<0.05). The difference between seroreactivities to E6 and E7 proteins in the patients with episomal forms of HPV-16 DNA (pure episomal and mixed forms) and those with integrated froms of HPV-16 DNA was not significant (P>0.05). CONCLUSION: Integrated forms of HPV-16 DNA were prevalent in most patients with cervical cancer. Antibodies to HPV-16 Ll/L2 VLPs, in vitro translated HPV-16 E6 and E7 proteins appeared in the significantly larger proportions of the HPV-associated cervical cancer patients than in the controls. Antibodies to HPV-16 Ll/L2 VLPs were more detectable in the cervical cancer patients with episomal form of HPV-16 DNA than those who having only integrated forms of HPV-16. Antibody responses to HPV-16 E6 and E7 proteins were not influenced by the different viral states. More numbers of studies would be necessary to determine the relationship between the genomic states of HPV and the immune responses to their proteins by the such genomic and serologic parameters.

3,114 View
25 Download

Change of the Antigenecity of Human Papillomavirus Type 16 E7 Oncoprotein according to Phosphorylation: No Hyun Park, Sun Ho Kee, Joo Won Noh, Jae Weon Kim, Yong Sang Song, Soon Beom Kang, Hyo Pyo Lee; J Korean Cancer Assoc. 1998;30(2):313-320.

Abstract PDF: PURPOSE
It was suggested that immunogenic region of E7 proteins of human papillo- mavirus (HPV) type 16 encompass casein kinase (CK) II phosphorylation site and the resulting negative charge may affect the various biologic function of E7 protein. This study was undertaken to analyze the change of antigenic characteristics of HPV type 16, E7 oncoprotein according to phosphorylation.
MATERIALS AND METHODS
We produced two monoclonal antibodies (VD6 and IB10) which showed different reactivities to E7 proteins expressed from bacteria or extracted from CaSki cell. These reaction were analyzed by Western blotting. Also the antigenic sites estimation of these antibodies using nested deletion sets was done. On the basis of above experiments, we performed in vitro phosphorylation assay using CK II and its specific inhibitor, DRB (5, 6-dichloro-l-beta-D-ribofuranosylbenzimidazole), to analyze the IB10 reactivity to E7 oncoproteins according to phosphorylation.
RESULTS
In Westem blot analysis, VD6 and IB10 antibodies reacted strongly to bacterially expressed E7 protein. But using E7 extracted from CaSki cell, VD6 reacted to 2.0 kDa E7 protein whereas IB10 showed weak reactivity. The antigenic sites estimation of these antibodies showed that antigenic site of VD6 was located in amino terminal region and that of IB10 in the middle portion in the range of approximate amino acid 25-45. The antigenic site of IB10 might contain the possible phosphorylation sites (Ser-31, 32) in E7. Considering this, the different reactivities of IB10 to E7 proteins expressed in bacteria and extracted from CaSki cell might be due to phosphorylation. In in vitro phosphorylation assay using CK II, the phosphorylation of E7 increased according to reaction time. And this phosphorylation reduced the reactivity of IB10 to E7 protein whereas the reactivity of VD6 did not change. Also the reactivity of IB10 to E7 protein increased in a dose dependent manner with CK II specific inhibitor, DRB treated CaSki cell extracts.
CONCLUSION
These result showed the antigenecity is affected by the degree of phosphorylation of E7 protein.

2,405 View
13 Download

The Association of p53 Mutation with Human Papillomavirus Type 16 , 18 Infection and its Clinical Significance: Chang Soo Park, Yong Sang Song, Chang Won Koh, Hye Won Jeon, Soon Beom Kang, Hyo Pyo Lee; J Korean Cancer Assoc. 1996;28(1):122-138.

Abstract PDF: Recent several studies have suggested that inactivation of p53 gene could occur by two theoretical mechanisms in cervical cancer. The E6 transforming protein of oncogenic human papillomavirus(HPV) binds to and promotes the degradation of p53 protein, or the mutation of the p53 gene could result in its inactivation without HPV infection. The purpose of this study were to investigate HPV infection and p53 mutation according to the status of lymph node metastasis and to analyse the relationship and role of HPV infection and p53 alteration in the advance and metastasis of cervical cancer. Paraffin embedded tissue sections were obtained from 30 patients with cervical cancer, each l5 patients with or without lymph node metastasis. The PCR and Southern blotting were used for the detection of HPV l6/18 DNA. Alteration of p53 activity was evaluated by immunohistochemistry using MAb DO7 and polymerase chain reaction with single stranded conformation polymorphism(PCR-SSCP). There was no significant difference in HPV infection between two groups, 73.3%(l l/15) in negative lymph node group and 80.0%(l2/15) in positive lymph node group. Although by immunohistochemistry p53 alterations were found more frequently in positive lymph node group(46.7%) than in negative lymph node group(20.0%), there was no significant difference between two groups. HPV negative cervical cancers had more p53 alterations(57.l%) than HPV positive cervical cancers(26.1%). However, there was no significant inverse relationship between HPV infection and p53 alteration. In conclusion, these data suggest that HPV infection and p53 alteration may play an important role independantly in the development of cervical cancer and p53 alteration may be associated with the advance and metastasis in some cases.

2,598 View
19 Download

First
Prev
Page of 1
Next
Last

Search