Cancer Research and Treatment

Original Articles

Human Papillomavirus Genotype-Specific Persistence and Potential Risk Factors among Korean Women: Results from a 2-Year Follow-up Study: Cecile Ingabire, Min Kyung Lim, Young-Joo Won, Jin-Kyoung Oh; Cancer Res Treat. 2018;50(3):813-822. Published online August 17, 2017; DOI: https://doi.org/10.4143/crt.2017.340

Abstract PDF Supplementary Material PubReader ePub

Purpose
High-risk human papillomavirus (HPV) infection progression should be considered a critical factor for preventing cervical cancer, although most infections are transient and rarely persist. This study aimed to examine the specific types of HPV infections, their change patterns, and the potential risk factors among Korean women.
Materials and Methods
We included 4,588 women who visited hospitals in Busan and Suwon for cervical cancer screening, and 1,224 of thesewomen attended a 2-yearfollow-up. Infection statuswas evaluated using HPV DNA testing (Hybrid Capture 2) and genotyping testing (Linear Array). Data regarding the potential risk factors for HPV infection were collected by trained nurses using structured questionnaires.
Results
Among the 1,224 women (mean age, 47 years), 105 women (8.6%) were HPV-positive at baseline. HPV infections had been cleared among 92 women (87.6%) within 2 years. Only 13 infections (12.4%) were remained, and the 10 cases of them are high-risk HPV types including genotype 33, 45, 16, 35, and 52. Among women who were negative at baseline, the HPV incidence was 4.8%. The HPV incidence was marginally associated with having multiple sexual partners (odds ratio, 2.0; 95% confidence interval, 1.0 to 3.9), although it was not significantly associated with HPV persistence.
Conclusion
Most HPV infections (88%) among Korean women were cleared within 2 years, with only a small number of persistent infections. The persistent HPV genotypes were different in our study, compared to those from previous studies. Having multiple sexual partners was associated with acquiring a HPV infection, but not with persistence.

Citations

Citations to this article as recorded by

Investigation of Human Papillomavirus (HPV) Frequency and Genotype Analysis in Cervical Samples
Yeliz Çetinkol, Selahattin Ünlü, Melahat Gürbüz, Cengiz Demir
Journal of Biotechnology and Strategic Health Research.2024; 8(1): 50. CrossRef
Global pattern of persistent human papillomavirus infection in female genital tract: An update system review and meta-analysis
Ming Zhao, Peipei Kang, Liling Zhu, Dan Zhou, Meimei Cui, Min Zhang, Jingjing Jia, Limei Luo
iScience.2024; 27(10): 110991. CrossRef
Analysis of Human Papilloma Virus Infection and Genotype in 336 Patients
秋培谭
Hans Journal of Biomedicine.2023; 13(02): 184. CrossRef
Characteristic of persistent human papillomavirus infection in women worldwide: a meta–analysis
Ming Zhao, Dan Zhou, Min Zhang, Peipei Kang, Meimei Cui, Liling Zhu, Limei Luo
PeerJ.2023; 11: e16247. CrossRef
Factors associated with persistence and clearance of HPV16/18 among rural Chinese women: a cohort study in Wufeng, Hubei province
Shuqi Pan, Wenshuang Wei, Xueying Du, Zhi Li, Jiyu Tuo, Min Zhang, Qing Liu
Women & Health.2022; 62(4): 276. CrossRef
Lactobacillus crispatus M247 oral administration: Is it really an effective strategy in the management of papillomavirus-infected women?
Miriam Dellino, Eliano Cascardi, Antonio Simone Laganà, Giovanni Di Vagno, Antonio Malvasi, Rosanna Zaccaro, Katia Maggipinto, Gerardo Cazzato, Salvatore Scacco, Raffaele Tinelli, Alessandro De Luca, Marina Vinciguerra, Vera Loizzi, Antonella Daniele, Ett
Infectious Agents and Cancer.2022;[Epub] CrossRef
Alternative New Mono-scaled Quantitative Benefit–Risk Assessment of Human Papillomavirus Vaccine in Japan
Tomoko Matsumoto, Naoki Matsumaru, Paul Scuffham, Pieter Neels, Katsura Tsukamoto
Therapeutic Innovation & Regulatory Science.2021; 55(1): 48. CrossRef
Next‐generation sequencing for typing human papillomaviruses and predicting multi‐infections and their clinical symptoms
Sang‐Yeon Kim, Kyung‐A Hwang, Ji‐Hoon Ann, Ji‐Hye Kim, Jae‐Hwan Nam
Microbiology and Immunology.2021; 65(7): 273. CrossRef
Association of age and viral factors with high-risk HPV persistence: A retrospective follow-up study
Wending Li, Yifan Meng, Yi Wang, Xiaodong Cheng, Chen Wang, Songshu Xiao, Xiaofei Zhang, Zaixing Deng, Mengjun Hu, Pingrong Shen, Shengfeng Xu, Chenglin Fu, Wen Jiang, Bing Wu, Kezhen Li, Gang Chen, Juncheng Wei, Ling Xi, Junbo Hu, Ding Ma, Min Xue, Xing
Gynecologic Oncology.2019; 154(2): 345. CrossRef
Prevalence of HPV Among HIV-Negative Women of Child-Bearing Age in Lomé, Togo
Yawo Tufa Nyasenu, Fifonsi A Gbeasor-Komlanvi, Sabi Abdul-Raouf Issa, Amivi Ehlan, Martin Kouame Tchankoni, Brice M Yambiyo, Mireille Prince-David, Mounerou Salou, Didier K Ekouevi, Anoumou Dagnra
Future Virology.2019; 14(12): 783. CrossRef

10,389 View
222 Download
9 Web of Science
10 Crossref

The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study: Kyeong A So, Mi Jung Kim, Ki-Heon Lee, In-Ho Lee, Mi Kyung Kim, Yoo Kyung Lee, Chang-Sun Hwang, Mi Seon Jeong, Mee-Kyung Kee, Chun Kang, Chi Heum Cho, Seok Mo Kim, Sung Ran Hong, Ki Tae Kim, Won-Chul Lee, Jong Sup Park, Tae Jin Kim; Cancer Res Treat. 2016;48(4):1313-1320. Published online March 9, 2016; DOI: https://doi.org/10.4143/crt.2016.013

Abstract PDF PubReader ePub

Purpose
The purpose of this study is to evaluate the impact of high-risk human papillomaviruses (HPVs) other than HPV 16/18 on the natural course of atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL).
Materials and Methods
The study population was derived from the Korean HPV cohort (2010-2014). Women aged 20 to 60 who satisfied the criteria of having both HPV infection and abnormal cervical cytology of either ASC-US or LSIL were recruited from five institutions nationwide. Enrolled patients underwent cervical cytology and HPV DNA testing every 6 months.
Results
A total of 1,158 patients were enrolled. The 10 most common HPV types were HPV 16 (12.3%), 58 (10.0%), 56 (8.8%), 53 (8.4%), 52 (7.7%), 39 (6.2%), 18 (6.0%), 51 (5.7%), 68 (5.1%), and 66 (4.6%). Among these patients, 636 women were positive for high-risk HPVs other than HPV 16 or 18, and 429 women were followed for more than 6 months. Cytology evaluations showed progression in 15.3% of women, no change in 22.6%, and regression in 62.1% of women at 12 months. In cases of HPV 58 single infection, a more highly significant progression rate, compared to other high-risk types, was observed at 6 months (relative risk [RR], 3.3; 95% confidence interval [CI], 2.04 to 5.30; p < 0.001) and 12 months (RR, 5.03; 95% CI, 2.56 to 9.91; p < 0.001).
Conclusion
HPV genotypes numbered in the 50s were frequent in Korean women with ASC-US and LSIL. HPV 58 was the second most common type, with a high progression rate of cervical cytology.

Citations

Citations to this article as recorded by

Women 50 Years and Older With Negative Pap Test and Positive Human Papillomavirus Test for Genotypes Other Than 16 and 18—Follow-up Outcomes
Farah S. Baban, Michael R. Henry, Margaret E. Long, Meredith A. VandeHaar, Grant M. Spears, Sarah M. Jenkins, Diva R. Salomao
Journal of Lower Genital Tract Disease.2024; 28(1): 43. CrossRef
Cervical intraepithelial neoplasia in non-16/18 high-risk human papilloma virus positive/cytology negative women: An alternative approach in poor resource areas
Fariba Yarandi, Elham Shirali, Elham Feizabad, Sara Ramhormoziyan, Soheila Sarmadi, Maryam SadrAmeli, Elham Arshadi
Taiwanese Journal of Obstetrics and Gynecology.2023; 62(2): 299. CrossRef
Molecular markers predicting the progression and prognosis of human papillomavirus-induced cervical lesions to cervical cancer
Fatema Alzahraa Samy Amin, Zeba Un Naher, P. Shaik Syed Ali
Journal of Cancer Research and Clinical Oncology.2023; 149(10): 8077. CrossRef
Herpes Simplex Virus, Human Papillomavirus, and Cervical Cancer: Overview, Relationship, and Treatment Implications
Daniel Sausen, Oren Shechter, Elisa Gallo, Harel Dahari, Ronen Borenstein
Cancers.2023; 15(14): 3692. CrossRef
Association strength of E6 to E6AP/p53 complex correlates with HPV‐mediated oncogenesis risk
Matheus Vitor Ferreira Ferraz, Isabelle Freire Tabosa Viana, Danilo Fernandes Coêlho, Carlos Henrique Bezerra da Cruz, Maíra de Arruda Lima, Madson Allan de Luna Aragão, Roberto Dias Lins
Biopolymers.2022;[Epub] CrossRef
Diagnostic performance of immediate colposcopy among women with high‐risk human papillomavirus (HPV) other than HPV 16/18 and normal cytology
Serdar Aydın, Hande Nur Öncü, Dilek Sema Arıcı
Journal of Obstetrics and Gynaecology Research.2021; 47(2): 720. CrossRef
Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer
Rachelle P. Mendoza, Tahmineh Haidary, Elmer Gabutan, Ying Yin Zhou, Zaheer Bukhari, Courtney Connelly, Wen-Ching Lee, Yi-Chun Lee, Raj Wadgaonkar, Raag Agrawal, M. A. Haseeb, Raavi Gupta
Scientific Reports.2021;[Epub] CrossRef
Distribution of HPV genotypes among women with abnormal cytology results in Alberta, Canada
Sabrina S Plitt, Ryan Kichuk, Sheena Geier, Trenton Smith, Felicia Roy, Alberto Severini, Carmen L Charlton
Journal of the Association of Medical Microbiology and Infectious Disease Canada.2021; 6(2): 94. CrossRef
The Clinical Significance and Utility of HPV-DNA Testing in Korean Women with Atypical Glandular Cells in Cervical Pap Tests: An Analysis of 311 Cases at a Single Institution
Tae-Kyu Jang, Jeong-Yeol Park, Dae-Yeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
Cancer Investigation.2021; 39(10): 885. CrossRef
Enhanced disease progression due to persistent HPV-16/58 infections in Korean women: a systematic review and the Korea HPV cohort study
Jaehyun Seong, Sangmi Ryou, JeongGyu Lee, Myeongsu Yoo, Sooyoung Hur, Byeong-Sun Choi
Virology Journal.2021;[Epub] CrossRef
Risk of cervical lesions in high-risk HPV positive women with normal cytology: a retrospective single-center study in China
Zhiling Wang, Ting Liu, Yunjian Wang, Ying Gu, Hui Wang, Jingkang Liu, Baoxia Cui, Xingsheng Yang
Infectious Agents and Cancer.2020;[Epub] CrossRef
Co-infection between genotypes of the human papillomavirus and Chlamydia trachomatis in Mexican women
Marco A Escarcega-Tame, Marcela López-Hurtado, Marcos R Escobedo-Guerra, Elba Reyes-Maldonado, Graciela Castro-Escarpulli, Fernando M Guerra-Infante
International Journal of STD & AIDS.2020; 31(13): 1255. CrossRef
Artificial intelligence estimates the impact of human papillomavirus types in influencing the risk of cervical dysplasia recurrence: progress toward a more personalized approach
Giorgio Bogani, Antonino Ditto, Fabio Martinelli, Mauro Signorelli, Valentina Chiappa, Umberto Leone Roberti Maggiore, Francesca Taverna, Claudia Lombardo, Chiara Borghi, Cono Scaffa, Domenica Lorusso, Francesco Raspagliesi
European Journal of Cancer Prevention.2019; 28(2): 81. CrossRef
Human papillomavirus genotype-specific risk in cervical carcinogenesis
Kyeong A So, In Ho Lee, Ki Heon Lee, Sung Ran Hong, Young Jun Kim, Hyun Hee Seo, Tae Jin Kim
Journal of Gynecologic Oncology.2019;[Epub] CrossRef
Comparison of the PANArray HPV Genotyping Chip Test with the Cobas 4800 HPV and Hybrid Capture 2 Tests for Detection of HPV in ASCUS Women
Eun Young Ki, Yoon Kyung Lee, Ahwon Lee, Jong Sup Park
Yonsei Medical Journal.2018; 59(5): 662. CrossRef
Genetic variability in E6, E7 and L1 genes of Human Papillomavirus 62 and its prevalence in Mexico
Cristina Artaza-Irigaray, María Guadalupe Flores-Miramontes, Dominik Olszewski, María Teresa Magaña-Torres, María Guadalupe López-Cardona, Yelda Aurora Leal-Herrera, Patricia Piña-Sánchez, Luis Felipe Jave-Suárez, Adriana Aguilar-Lemarroy
Infectious Agents and Cancer.2017;[Epub] CrossRef

34,002 View
301 Download
16 Web of Science
16 Crossref

Subtypes of Epstein - Barr Virus in Malignant Lymphoma in Korea: Kyung Eun Choi, Eun Yoon Cho, Chan Kum Park, Won Keun Lee, Young Hyeh Ko; J Korean Cancer Assoc. 1998;30(2):338-349.

Abstract PDF: PURPOSE
Epstein-Barr virus(EBV) exists in the human population in two genetic forms, usually referred to as type 1 and type 2 which have been defined on the basis of sequence divergence in the EBNA-2 and EBNA-3 family genes. In this study, we were intended to investigate whether the subtypes of EBV in malignant lymphoma in Korea were associated with specific disease entities and geographical distribution.
MATERIALS AND METHODS
Biopsy samples obtained from 18 Korean patients with malignant lymphoma including Hodgkin's disease(3 cases), B cell lymphoma(1 case), and NK/T cell lymphoma(14 cases) were analyzed to determine the subtype of EBV infected therein. DNA was extracted from formalin-fixed, paraffin-embeded tissues by ordinary method and specific viral sequences were sought using the polymerase chain reaction(PCR) and Southern blot hybridization assay. Oligonucleotide primers used for examination of EBV strain type were derived from the EBNA-3B and EBNA-3C coding regions. As a control, four cases of reactive hyperplasia were analyzed.
RESULTS
The two of four reactive hyperplasia cases were associated with type 1 and the rest of two cases with both types. Among the 18 cases with malignant lymphoma, thirteen cases(72%) had type 1, one(6%) had type 2, and four(22%) had dual infections with both types. In case of NK/T cell lymphoma(14 cases) occupying 78% of 18 biopsy samples, 86%(12 cases) were associated with type 1, 7%(1 case) with type 2, and 7%(1 case) with both types. In case of Hodgkin's disease, all of three cases had both types. B cell lymphoma taking only one case of twenty two cases was determined as type 1.
CONCLUSION
These observations indicated that type 1 EBV was predominant in Korean patients with malignant lymphoma, especially NK/T cell lymphoma and showed high frequency of dual viral infections(22%) in Hodgkin's disease as well as in reactive hyperplasia.

2,648 View
14 Download

First
Prev
Page of 1
Next
Last

Search