Cancer Research and Treatment

Original Articles

Hematologic malignancy

Long-term Psychiatric and Endocrine Complications Following Hematopoietic Stem Cell Transplantation in Hematologic Disease in Korea: A Nation-Wide Cohort Study: Min Ji Jeon, Eunjin Noh, Seok Joo Moon, Eun Sang Yu, Chul Won Choi, Dae Sik Kim, Eun Joo Kang; Cancer Res Treat. 2024;56(4):1262-1269. Published online May 9, 2024; DOI: https://doi.org/10.4143/crt.2024.047

Purpose
Numerous patients experience long-term complications after hematopoietic stem cell transplantation (HSCT). This study aimed to identify the frequency and risk factors for psychiatric and endocrine complications following HSCT through big data analyses.
Materials and Methods
We established a cohort of patients with hematologic disease who underwent HSCT in Korea between 2010 and 2012 using the Health Insurance Review & Assessment Service data. A total of 3,636 patients were identified, and insurance claims were tracked using psychiatric and endocrine diagnostic International Classification of Diseases, 10th Revision codes for the ensuing decade. We identified the incidence rates of long-term complications based on the baseline disease and HSCT type. Prognostic factors for each complication were scrutinized using logistic regression analysis.
Results
A total of 1,879 patients underwent allogeneic HSCT and 1,757 patients received autologous HSCT. Post-HSCT, 506 patients were diagnosed with depression, 465 with anxiety disorders, and 659 with diabetes. The highest incidence of long-term complications occurred within the first year post-HSCT (12.2%), subsequently decreasing over time. Risk factors for depressive disorders after allogeneic HSCT included female sex, a total body irradiation–based conditioning regimen, and cyclosporine. Identified risk factors for diabetes mellitus comprised old age, total body irradiation–based conditioning regimen, and non-antithymocyte globulin protocol. Regarding autologous HSCT, only female sex was identified as a risk factor for depressive disorders, whereas elderly patients and those with multiple myeloma were identified as poor prognostic factors for diabetes mellitus.
Conclusion
The incidence of long-term psychiatric and endocrine complications post-HSCT remains high, and patients with risk factors for these complications require vigilant follow-up.

Citations

Citations to this article as recorded by

Psychological Prehabilitation for People Undergoing Autologous Stem Cell Transplant: A Qualitative Study
K. Wilkin, F. Lynch, J. Todd, V. White
Psycho-Oncology.2026;[Epub] CrossRef

3,945 View
106 Download
2 Web of Science
1 Crossref

Lung and Thoracic cancer

Predictive Value of Interstitial Lung Abnormalities for Postoperative Pulmonary Complications in Elderly Patients with Early-stage Lung Cancer: Won Gi Jeong, Yun-Hyeon Kim, Jong Eun Lee, In-Jae Oh, Sang Yun Song, Kum Ju Chae, Hye Mi Park; Cancer Res Treat. 2022;54(3):744-752. Published online September 28, 2021; DOI: https://doi.org/10.4143/crt.2021.772

Abstract PDF Supplementary Material PubReader ePub

Purpose
Identifying pretreatment interstitial lung abnormalities (ILAs) is important because of their predictive value for complications after lung cancer treatment. This study aimed to assess the predictive value of ILAs for postoperative pulmonary complications (PPCs) in elderly patients undergoing curative resection for early-stage non-small cell lung cancer (NSCLC).
Materials and Methods
Elderly patients (age ≥ 70 years) who underwent curative resection for pathologic stage I or II NSCLC with normal preoperative spirometry results (pre-bronchodilator forced expiratory volume in 1 s to forced vital capacity [FVC] ratio > 0.70 and FVC ≥ 80% of the predicted value) between January 2012 and December 2019 were retrospectively identified. Univariable and multivariable regression analyses were performed to assess risk factors for PPCs. The Kaplan–Meier method and log-rank test were used to analyze the relationship between ILAs and postoperative mortality. One-way analysis of variance was performed to assess the correlation between ILAs and hospital stay duration.
Results
A total of 262 patients (median age, 73 [interquartile range, 71–76] years; 132 male) were evaluated. A multivariable logistic regression model revealed that, among several relevant risk factors, fibrotic ILAs independently predicted both overall PPCs (adjusted odds ratio [OR], 4.84; 95% confidence interval [CI], 1.35–17.38; p=0.016) and major PPCs (adjusted OR, 8.72; 95% CI, 1.71–44.38; p=0.009). Fibrotic ILAs were significantly associated with higher postoperative mortality and longer hospital stay (F=5.21, p=0.006).
Conclusion
Pretreatment fibrotic ILAs are associated with PPCs, higher postoperative mortality, and longer hospital stay.

Citations

Citations to this article as recorded by

Progression of interstitial lung abnormalities and its impact on mortality in patients with lung cancer resection
Ruolin Mao, Haoyun Zhang, Qing Chang, Yilong Teng, Yanfen Ni, Jiani Chen, Mengnan Li, Ning Xu, Hai Zhang, Yuqing Chen, Jianqi Sun, Kian Fan Chung, Elisabetta A. Renzoni, Yi Lu, Huaping Dai, Feng Li
Chinese Medical Journal Pulmonary and Critical Care Medicine.2026; 4(1): 81. CrossRef
Automated quantification of interstitial lung abnormalities and emphysema on computed tomography: a predictive marker for postoperative pulmonary complications after esophagectomy
Seong Yong Park, Yunjoo Im, Jonghoon Kim, You Jin Oh, Joonghyun Ahn, Yeong Jeong Jeon, Junghee Lee, Jong Ho Cho, Hong Kwan Kim, Yong Soo Choi, Jae Il Zo, Young Mog Shim, Hye Yun Park, Ho Yun Lee
Esophagus.2026;[Epub] CrossRef
Prevalence and prognostic significance of interstitial lung abnormalities in lung cancer: A meta-analysis
Ruiyuan Yang, Haoyu Wang, Dan Liu, Weimin Li
Lung Cancer.2025; 205: 108458. CrossRef
Approach to the Evaluation and Management of Interstitial Lung Abnormalities: An Official American Thoracic Society Clinical Statement
Anna J. Podolanczuk, Gary M. Hunninghake, Kevin C. Wilson, Yet H. Khor, Fayez Kheir, Brandon Pang, Ayodeji Adegunsoye, Gretchen Cararie, Tamera J. Corte, Jim Flanagan, Gunnar Gudmundsson, Lida P. Hariri, Hiroto Hatabu, Stephen M. Humphries, Bhavika Kaul,
American Journal of Respiratory and Critical Care Medicine.2025; 211(7): 1132. CrossRef
Korean Guidelines for Diagnosis and Management of Interstitial Lung Diseases
Chul Park, Yoomi Yeo, A La Woo, Jung Wan Yoo, Goohyeon Hong, Jong Wook Shin, Sung Woo Park
Tuberculosis and Respiratory Diseases.2025; 88(4): 654. CrossRef
Pretreatment Interstitial Lung Abnormalities Detected on Abdominal Computed Tomography Scans in Prostate Cancer Patients
Hyun Jin Kim, Won Gi Jeong, Jeong Yeop Lee, Hyo-Jae Lee, Byung Chan Lee, Hyo Soon Lim, Yun-Hyeon Kim
Journal of Computer Assisted Tomography.2024; 48(3): 406. CrossRef
Interstitial Lung Abnormalities
Noriaki Wada, Gary M. Hunninghake, Hiroto Hatabu
Clinics in Chest Medicine.2024; 45(2): 433. CrossRef
Incidence and risk factors of pulmonary complications after lung cancer surgery: A systematic review and meta-analysis
Ting Deng, Jiamei Song, Jinmei Tuo, Yu Wang, Jin Li, Lorna Kwai Ping Suen, Yan Liang, Junliang Ma, Shaolin Chen
Heliyon.2024; 10(12): e32821. CrossRef
Survival impact of fibrotic interstitial lung abnormalities in resected stage IA non-small cell lung cancer
Won Gi Jeong, Yun-Hyeon Kim
The British Journal of Radiology.2023;[Epub] CrossRef
Radiologic Progression of Interstitial Lung Abnormalities following Surgical Resection in Patients with Lung Cancer
Yoon Joo Shin, Jeong Geun Yi, Mi Young Kim, Donghee Son, Su Yeon Ahn
Journal of Clinical Medicine.2023; 12(21): 6858. CrossRef
Mycophenolate mofetil versus cyclophosphamide plus in patients with connective tissue disease-associated interstitial lung disease: Efficacy and safety analysis
Pengfei Wang, Li Zhang, Qian Guo, Lifen Zhao, Yanyan Hao
Open Medicine.2023;[Epub] CrossRef
Clinical implication of interstitial lung abnormality in elderly patients with early‐stage non‐small cell lung cancer
Seong Woo Cho, Won Gi Jeong, Jong Eun Lee, In‐Jae Oh, Sang Yun Song, Hye Mi Park, Hyo‐Jae Lee, Yun‐Hyeon Kim
Thoracic Cancer.2022; 13(7): 977. CrossRef

9,656 View
180 Download
14 Web of Science
12 Crossref

General

The Fear of Cancer from the Standpoint of Oneself, the Opposite Sex and the Fear of Side Effects of Cancer Treatment: Keeho Park, Youngae Kim, Hyung Kook Yang, Hye Sook Min; Cancer Res Treat. 2020;52(4):993-1001. Published online June 24, 2020; DOI: https://doi.org/10.4143/crt.2020.285

Abstract PDF Supplementary Material PubReader ePub

Purpose
It is important to understand the differences between men and women when it comes to attitudes and risk perception toward disease. This study aimed to explore the fear of cancer from the standpoint of themselves and the opposite sex by cancer type.
Materials and Methods
A cross-sectional survey with a representative sample was conducted.
Results
The least and the most feared cancers in men were thyroid cancer and lung cancer, respectively. When men assumed the perspective of women, the least and the most feared cancer were thyroid cancer and stomach cancer, respectively. The least and the most feared cancers in women were thyroid cancer and stomach cancer, respectively. When women assumed the perspective of men, the least and the most feared cancer were prostate cancer and lung cancer, respectively. When both men and women assume the perspective of the opposite sex, the fear of sex-specific cancer was relatively low compared to the actual responses of both men and women. The top six of the most feared side effects of cancer treatment were pain, psychological problems, general weakness, digestive dysfunction, fatigue, and appearance change. These were the same between men and women.
Conclusion
Health care providers and caregivers in the family should provide care with more attention to the differences in thoughts about cancer between men and women. Health care providers should provide care with more attention to the differences in these problems between men and women.

Citations

Citations to this article as recorded by

“Teetering on a Tightrope”: Uncertainty and Information Management During the Cancer Pre-Diagnosis Phase
Lisa Glebatis Perks, Andrew C. Tollison
Western Journal of Communication.2025; 89(2): 349. CrossRef

9,422 View
193 Download
7 Web of Science
1 Crossref

Computed Tomography–Determined Sarcopenia Is a Useful Imaging Biomarker for Predicting Postoperative Outcomes in Elderly Colorectal Cancer Patients: Hailun Xie, Yizhen Gong, Jiaan Kuang, Ling Yan, Guotian Ruan, Shuangyi Tang, Feng Gao, Jialiang Gan; Cancer Res Treat. 2020;52(3):957-972. Published online April 17, 2020; DOI: https://doi.org/10.4143/crt.2019.695

Abstract PDF PubReader ePub

Purpose
This study aimed to establish whether computed tomography (CT)–determined sarcopenia is a useful imaging biomarker for postoperative outcome in elderly colorectal cancer (CRC) patients, and construct sarcopenia-based nomograms to predict individual outcomes after surgery.
Materials and Methods
CT imaging data of 298 elderly CRC patients who underwent surgery in 2012-2014 were retrospectively analyzed. Skeletal muscle mass was determined by CT, and sarcopenia was diagnosed based on the optimal cutoff value determined by X-tile program. The correlation between sarcopenia and risk of preoperative nutrition and postoperative complications was evaluated. A Cox proportional hazards model was used to determine survival predictors. Sarcopenia-based nomograms were developed based on multivariate analysis, and calibrated using concordance index and calibration curves.
Results
A total 132 patients (44.3%) had sarcopenia based on the optimum cutoff values (29.9 cm2/m2 for women and 49.5 cm2/m2 for men). Sarcopenia was an independent risk factor for preoperative nutrition (p < 0.001; odds ratio [OR], 3.405; 95% confidence interval [CI], 1.948 to 5.954) and postoperative complications (p=0.008; OR, 2.192; 95% CI, 1.231 to 3.903). Sarcopenia was an independent predictor for poor progression-free survival (p < 0.001; hazard ratio [HR], 2.175; 95% CI, 1.489 to 3.179) and overall survival (p < 0.001; HR, 2.524; 95% CI, 1.721 to 3.703). Based on multivariate analysis, we produced four nomograms that had better predictive performance.
Conclusion
CT-determined sarcopenia is a useful imaging biomarker for predicting preoperative nutritional risk, postoperative complications, and long-term outcomes in elderly CRC patients. The sarcopenia-based nomograms can provide a scientific basis for guiding therapeutic schedule and follow-up strategies.

Citations

Citations to this article as recorded by

Efficacy, safety, and population pharmacokinetics of eravacycline for carbapenem-resistant organism infections in immunocompromised hosts: A multicenter prospective cohort study
Yifu Hou, Lijuan Zhang, Hong Li, Linhong Zhong, Hua Zhang, Tian Tang, Xiangde Zheng, Rui Zhou, Sheng Lv, Qing Que, Bo Tan, Li Chen, Yiyun Hsu, Huan Hu, Jun Shen, Ruiming Yue, Kai Chen, Wenjia Di, Lu Guo, Lu Chen, Hua Yu, Xiangning Huang, Xiaobo Huang, Chu
International Journal of Antimicrobial Agents.2026; 67(6): 107795. CrossRef
Prognostic value of computed tomography-based sarcopenia for overall and disease-free survival in rectal cancer: an updated systematic review and meta-analysis
María Josefa Moreno Martínez, Antonio Jesús Láinez Ramos-Bossini, Ángela Reinoso Espín, David Luengo Gómez, Ángela Salmerón Ruiz, Andrea Torres Roa
Revista Española de Enfermedades Digestivas.2026;[Epub] CrossRef
The Weight of Nutrition on Post-Resection Oncologic Morbidity and Mortality: A Systematic Review and Meta-Analysis of Nutritional Indices
Katherine Pierce, Jeremy Gaskins, Robert C G Martin II
Nutrition Reviews.2025; 83(6): 988. CrossRef
Comparative study of imputation strategies to improve the sarcopenia prediction task
Shakhzod Karimov, Dilmurod Turimov, Wooseong Kim, Jiyoun Kim
DIGITAL HEALTH.2025;[Epub] CrossRef
The Impact of Sarcopenia on Postoperative Outcomes in Colorectal Cancer Surgery: An Updated Systematic Review and Meta-Analysis
Sara Keshavjee, Tyler Mckechnie, Victoria Shi, Muhammad Abbas, Elena Huang, Nalin Amin, Dennis Hong, Cagla Eskicioglu
The American Surgeon™.2025; 91(5): 887. CrossRef
Sarcopenia as a Prognostic Factor for the Outcomes of Surgical Treatment of Colorectal Carcinoma
Šimon Leščák, Martina Košíková, Sylvia Jenčová
Healthcare.2025; 13(7): 726. CrossRef
Preoperative body composition metrics as predictors for outcomes in colorectal cancer surgeries
Dorsa Salabat, Asma Mousavi, Shayan Shojaei, Razman Arabzadeh Bahri, Hanieh Radkhah
Annals of Medicine & Surgery.2025; 87(4): 2243. CrossRef
Prognostic significance of anthropometric measurements in gastric cancer: a multicenter cohort study
Hailun Xie, Lishuang Wei, Shuyao Wang, Hanping Shi, Junqiang Chen
Supportive Care in Cancer.2025;[Epub] CrossRef
Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies
Efthymios Papadopoulos, Brian A. Irving, Justin C. Brown, Steven B. Heymsfield, Schroder Sattar, Shabbir M. H. Alibhai, Grant R. Williams, Richard F. Dunne
Drugs & Aging.2025; 42(12): 1113. CrossRef
Abdominal computed tomography–assessed muscle quality and its prognostic value in patients with advanced chronic kidney disease initiating hemodialysis
Suyeon Han, Hwajin Park, Yu Ah Hong, Yunkyeong Hwang, Yoon-Kyung Chang, Zubing Mei
PLOS One.2025; 20(11): e0334929. CrossRef
Impact of New Inflammation/Nutrition‐Based Indicators on Prognosis in Elderly Patients With Colorectal Cancer
Wenda Xu, Chen Qin, Hanyu Yang, Haoyu Cui, Shuo Liu, Zechen Lu, Wenchang Yang, Jilin Hu, William Raoul
Mediators of Inflammation.2025;[Epub] CrossRef
Decrease in Psoas Muscle Mass and Density Following Liver Transplantation Is Greatest in Patients With the Highest Muscle Quantity and Density Pre‐Transplant
Michael G. Megaly, William C. Miller, Jessica Thul, Peter Gullickson, Abraham J. Matar, Michael Dryden, Matthew Wright, David Mathews, Jessica Fisher, Heidi Sarumi, Levi Teigen, Scott Lunos, Timothy L. Pruett
Clinical Transplantation.2025;[Epub] CrossRef
Recent advances in the research of sarcopenia in colorectal cancer
Yang Wang, Yuliuming Wang, Ming Liu
Holistic Integrative Oncology.2025;[Epub] CrossRef
Radiological Assessment of Sarcopenia and Its Clinical Impact in Patients with Hepatobiliary, Pancreatic, and Gastrointestinal Diseases: A Comprehensive Review
Shameema Farook, Saumya Soni, Arpit Shantagiri, Pankaj Gupta, Anindita Sinha, Mahesh Prakash
Journal of Gastrointestinal and Abdominal Radiology.2024; 07(01): 027. CrossRef
Developing sarcopenia during neoadjuvant therapy is associated with worse survival in esophageal adenocarcinoma patients
Katherine Pierce, Prejesh Philips, Michael E Egger, Charles R Scoggins, Robert CG Martin
Surgery.2024; 175(3): 718. CrossRef
PEX26 Functions as a Metastasis Suppressor in Colorectal Cancer
Bianbian Yan, Lichao Cao, Liyang Gao, Shangqing Wei, Mengwei Wang, Ye Tian, Jin Yang, Erfei Chen
Digestive Diseases and Sciences.2024; 69(1): 112. CrossRef
Post‐diagnosis adiposity and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis
Nerea Becerra‐Tomás, Georgios Markozannes, Margarita Cariolou, Katia Balducci, Rita Vieira, Sonia Kiss, Dagfinn Aune, Darren C. Greenwood, Laure Dossus, Ellen Copson, Andrew G. Renehan, Martijn Bours, Wendy Demark‐Wahnefried, Melissa M. Hudson, Anne M. Ma
International Journal of Cancer.2024; 155(3): 400. CrossRef
Predictive role of preoperative sarcopenia for long-term survival in rectal cancer patients: A meta-analysis
Qiutong Su, Jia Shen, Zubing Mei
PLOS ONE.2024; 19(5): e0303494. CrossRef
CT‐determined low skeletal muscle index predicts poor prognosis in patients with colorectal cancer
Yue Feng, Xiao‐Hong Cheng, Mei Xu, Rui Zhao, Qian‐Yi Wan, Wei‐Hua Feng, Hua‐Tian Gan
Cancer Medicine.2024;[Epub] CrossRef
Serum tumor marker and CT body composition scoring system predicts outcomes in colorectal cancer surgical patients
Mingming Song, Zhihao Liu, Feihong Wu, Tong Nie, Yixin Heng, Jiaxin Xu, Ning Huang, Xiaoyu Wu, Yinghao Cao, Gang Hu
European Radiology.2024; 34(12): 7596. CrossRef
Aminotransferase-to-lymphocyte ratio as a valuable prognostic marker for patients with stage I-III colorectal cancer: a retrospective study
Hailun Xie, Lishuang Wei, Shuangyi Tang, Jialiang Gan
Frontiers in Oncology.2024;[Epub] CrossRef
Impact of sarcopenia on outcomes in surgical patients: a systematic review and meta-analysis
Samuel Knoedler, Rainer Schliermann, Leonard Knoedler, Mengfan Wu, Frederik J. Hansen, Dany Y. Matar, Doha Obed, Dominique Vervoort, Valentin Haug, Gabriel Hundeshagen, Angie Paik, Martin Kauke-Navarro, Ulrich Kneser, Bohdan Pomahac, Dennis P. Orgill, Adr
International Journal of Surgery.2023; 109(12): 4238. CrossRef
Hand grip strength‐based cachexia index as a predictor of cancer cachexia and prognosis in patients with cancer
Hailun Xie, Guotian Ruan, Lishuang Wei, Heyang Zhang, Yizhong Ge, Qi Zhang, Shiqi Lin, Mengmeng Song, Xi Zhang, Xiaoyue Liu, Xiangrui Li, Kangping Zhang, Ming Yang, Meng Tang, Chun‐Hua Song, Jialiang Gan, Han‐Ping Shi
Journal of Cachexia, Sarcopenia and Muscle.2023; 14(1): 382. CrossRef
Impact of Sarcopenia on Clinical Course of Inflammatory Bowel Disease in Korea
Kwangwoo Nam, Jae Yong Lee, Yousun Ko, Kyung Won Kim, Ho-Su Lee, Seung Wook Hong, Jin Hwa Park, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byoun, Seung-Jae Myung, Suk-Kyun Yang, Sang Hyoung Park
Digestive Diseases and Sciences.2023; 68(6): 2165. CrossRef
Perioperative Nutritional Considerations in Colon and Rectal Surgery
Thomas Curran
Clinics in Colon and Rectal Surgery.2023; 36(03): 192. CrossRef
Prognostic significance of sarcopenia diagnosed based on the anthropometric equation for progression-free survival and overall survival in patients with colorectal cancer
Hailun Xie, Lishuang Wei, Shunhui Gao, Mingxiang Liu, Yanren Liang, Guanghui Yuan, Qiwen Wang, Yansong Xu, Shuangyi Tang, Jialiang Gan
Frontiers in Nutrition.2023;[Epub] CrossRef
The prognostic value of the combination of body composition and systemic inflammation in patients with cancer cachexia
Hai‐Lun Xie, Guo‐Tian Ruan, Lishuang Wei, Qi Zhang, Yi‐Zhong Ge, Meng‐Meng Song, Xi Zhang, Shi‐qi Lin, Xiao‐yue Liu, Xiao‐Wei Zhang, Xiang‐Rui Li, Kang‐Ping Zhang, Chun‐Lei Hu, Ming Yang, Meng Tang, Chun‐Hua Song, Ming‐Hua Cong, Min Weng, Zeng‐Ning Li, We
Journal of Cachexia, Sarcopenia and Muscle.2023; 14(2): 879. CrossRef
The predictive value of computerized tomography‐assessed sarcopenia for complicated appendicitis in geriatric patients
Ali Cihat Yildirim, Şahinde Atlanoğlu, Mehmet Ali Gedik, Sezgin Zeren, Mehmet Fatih Ekici
AGING MEDICINE.2023; 6(3): 222. CrossRef
Improving the assessment of malnutrition in cancer: Using systemic inflammation markers as a supplement to the inflammation items of the GLIM criteria
Hailun Xie, Kaitao Yuan, Guotian Ruan, Lishuang Wei, Heyang Zhang, Yizhong Ge, Shiqi Lin, Mengmeng Song, Ziwen Wang, Chenan Liu, Jinyu Shi, Xiaoyue Liu, Ming Yang, Xin Zheng, Yue Chen, Xiaowei Zhang, Hanping Shi
Clinical Nutrition.2023; 42(10): 2036. CrossRef
Computed tomography–assessed presarcopenia and clinical outcomes after laparoscopic surgery for rectal cancer
Ji Hyeong Song, Rak Kyun Oh, Jeong Eun Lee, Kyung Ha Lee, Ji Yeon Kim, Jin Soo Kim
Annals of Coloproctology.2023; 39(6): 513. CrossRef
CT-derived relationship between low relative muscle mass and bone damage in patients with multiple myeloma undergoing stem cells transplantation
Alberto Stefano Tagliafico, Federica Rossi, Bianca Bignotti, Lorenzo Torri, Alessandro Bonsignore, Liliana Belgioia, Alida Domineitto
The British Journal of Radiology.2022;[Epub] CrossRef
The Clinical Impact of Combining Neutrophil-to-Lymphocyte Ratio with Sarcopenia for Improved Discrimination of Progression-Free Survival in Patients with Colorectal Cancer
Su Young Lee, Eric Chung, Eun-Suk Cho, Jae-Hoon Lee, Eun Jung Park, Su-Jin Shin, Seung Hyuk Baik, Kang Young Lee, Jeonghyun Kang
Journal of Clinical Medicine.2022; 11(2): 431. CrossRef
Ability of malnutrition screening and assessment tools to identify computed tomography defined low muscle mass in colorectal cancer surgery
Aleksandra Djordjevic, Irene Deftereos, Vanessa M. Carter, Stephanie Morris, Roland Shannon, Nicole Kiss, Justin M. C. Yeung
Nutrition in Clinical Practice.2022; 37(3): 666. CrossRef
Clinical Relevance of Myopenia and Myosteatosis in Colorectal Cancer
Yoshinaga Okugawa, Takahito Kitajima, Akira Yamamoto, Tadanobu Shimura, Mikio Kawamura, Takumi Fujiwara, Ikuyo Mochiki, Yoshiki Okita, Masahiro Tsujiura, Takeshi Yokoe, Masaki Ohi, Yuji Toiyama
Journal of Clinical Medicine.2022; 11(9): 2617. CrossRef
Sarcopenia among older patients with cancer: A scoping review of the literature
Qian Sun, Xiaohan Jiang, Rui Qin, Yuanyuan Yang, Yabo Gong, Kunyuan Wang, Junsheng Peng
Journal of Geriatric Oncology.2022; 13(7): 924. CrossRef
Comparison of absolute and relative handgrip strength to predict cancer prognosis: A prospective multicenter cohort study
Hailun Xie, Guotian Ruan, Li Deng, Heyang Zhang, Yizhong Ge, Qi Zhang, Shiqi Lin, Mengmeng Song, Xi Zhang, Xiaoyue Liu, Xiangrui Li, Kangping Zhang, Ming Yang, Meng Tang, Wen Hu, Min Weng, Hanping Shi
Clinical Nutrition.2022; 41(8): 1636. CrossRef
Prognostic value of cachexia index in patients with colorectal cancer: A retrospective study
Qianyi Wan, Qian Yuan, Rui Zhao, Xiaoding Shen, Yi Chen, Tao Li, Yinghan Song
Frontiers in Oncology.2022;[Epub] CrossRef
Acute Sarcopenia after Elective and Emergency Surgery
Alvin Shrestha, Melanie Dani, Paul Kemp, Michael Fertleman
Aging and disease.2022; 13(6): 1759. CrossRef
Prognostic Significance of Preoperative Fibrinogen‐to‐Prealbumin Ratio in Patients with Stage I–III Colorectal Cancer Undergoing Surgical Resection: A Retrospective Cohort Study
Hailun Xie, Shizhen Huang, Guanghui Yuan, Shuangyi Tang, Jialiang Gan, Bing Wang
BioMed Research International.2021;[Epub] CrossRef
Sarcopenia predicts worse postoperative outcomes and decreased survival rates in patients with colorectal cancer: a systematic review and meta-analysis
Mario Trejo-Avila, Katya Bozada-Gutiérrez, Carlos Valenzuela-Salazar, Jesús Herrera-Esquivel, Mucio Moreno-Portillo
International Journal of Colorectal Disease.2021; 36(6): 1077. CrossRef
Preoperative optimization and enhanced recovery for colorectal surgery
Alexander T. Booth, Thomas Curran
Seminars in Colon and Rectal Surgery.2021; 32(3): 100827. CrossRef
Low CT attenuation and high fatty infiltration rate of psoas are risk factors for incisional hernias after appendicectomy: a cross-sectional single-center study from China
Xuechao Du, Pengtao Sun, Yuchang Yan, Xiang Gong, Yufei Lian, Zhenyu Pan
BMC Musculoskeletal Disorders.2021;[Epub] CrossRef
Oral Nutritional Supplements and Enteral Nutrition in Patients with Gastrointestinal Surgery
Maria Wobith, Arved Weimann
Nutrients.2021; 13(8): 2655. CrossRef
Preoperative computed tomography-assessed sarcopenia as a predictor of complications and long-term prognosis in patients with colorectal cancer: a systematic review and meta-analysis
Hailun Xie, Lishuang Wei, Mingxiang Liu, Guanghui Yuan, Shuangyi Tang, Jialiang Gan
Langenbeck's Archives of Surgery.2021; 406(6): 1775. CrossRef
Comparison of revised EWGSOP2 criteria of sarcopenia in patients with cancer using different parameters of muscle mass
Ana Paula Trussardi Fayh, Iasmin Matias de Sousa, Stephen E. Alway
PLOS ONE.2021; 16(9): e0257446. CrossRef
Impact of Computed Tomography-Based, Artificial Intelligence-Driven Volumetric Sarcopenia on Survival Outcomes in Early Cervical Cancer
Qingling Han, Se Ik Kim, Soon Ho Yoon, Taek Min Kim, Hyun-Cheol Kang, Hak Jae Kim, Jeong Yeon Cho, Jae-Weon Kim
Frontiers in Oncology.2021;[Epub] CrossRef
Geriatric nutritional risk index as a predictor of complications and long-term outcomes in patients with gastrointestinal malignancy: a systematic review and meta-analysis
Hailun Xie, Shuangyi Tang, Lishuang Wei, Jialiang Gan
Cancer Cell International.2020;[Epub] CrossRef

15,449 View
230 Download
47 Web of Science
47 Crossref

Case Report

Two Pediatric Osteosarcoma Cases with Delayed Methotrexate Excretion: Its Clinical Course and Management: Kang Min Lee, Hee Woo Lee, Seung Yeon Kim, Hyeon Jeong Lee, Dong Hwan Kim, Joongbum Cho, Dong Ho Kim, Jung Sub Lim, Jin Kyung Lee, Jun Ah Lee; Cancer Res Treat. 2011;43(1):67-70. Published online March 31, 2011; DOI: https://doi.org/10.4143/crt.2011.43.1.67

Abstract PDF PubReader ePub

High-dose methotrexate (MTX) chemotherapy extends the duration of hospitalization and introduces the risks of serious complications related to delayed MTX excretion. The treatment of delayed MTX excretion is largely dependent on invasive measures such as hemodialysis because the clinical data regarding the efficacy or safety of carboxypetidase G2 is limited. We report here on the cases of two pediatric osteosarcoma patients with delayed MTX excretion and who were successfully managed using supportive measures. Potential life-threatening complications were prevented by administering high doses of leucovorin.

Citations

Citations to this article as recorded by

The Role of Single Nucleotide Polymorphisms in Transporter Proteins and the Folate Metabolism Pathway in Delayed Methotrexate Excretion: A Case Report and Literature Review
Jun Wang, Yue-Tao Zhao, Meng-Jiao Sun, Feng Chen, Hong-Li Guo
Pharmacogenomics and Personalized Medicine.2022; Volume 15: 919. CrossRef
Toxicité rénale des anticancéreux
Blandine Aloy, Nicolas Janus, Corine Isnard-Bagnis, Gilbert Deray, Vincent Launay-Vacher
Néphrologie & Thérapeutique.2021; 17(7): 553. CrossRef
Delayed High-dose Methotrexate Excretion and Influencing Factors in Osteosarcoma Patients
Wei Zhang, Qing Zhang, Ting-Ting Zheng, Jian-Cun Zhen, Xiao-Hui Niu
Chinese Medical Journal.2016; 129(21): 2530. CrossRef

10,735 View
53 Download
3 Crossref

Original Articles

Laparoscopic Assisted Distal Rectal Cancer Resection with Preoperative Concurrent Chemoradiotherapy: Bong Hwa Lee, Mi Young Chang, Sung Kook Park, Taeik Eum, Hyun Joo Shin, Nam Kyu Ro, Chang Nam An, Hae Wan Lee, Lee Su Kim, Hyoung-Chul Park, Hoon Sik Bae, Dae Young Zang, Richard L Whelan; Cancer Res Treat. 2007;39(1):10-15. Published online March 31, 2007; DOI: https://doi.org/10.4143/crt.2007.39.1.10

Abstract PDF PubReader ePub

Purpose

Anatomy of deep pelvis, narrow distal margin and tumor invasion into neighbor organ are obstacles for curative radical resection for advanced cancer of distal rectum. Technically, laparoscopic application after downstaging the tumor with preoperative concurrent chemotherapy (CCRT) may give a solution to overcome the anatomical difficulties. We compared the results of laparoscopic surgery in the patients who received CCRT with those of patients who had conventional surgery.

Materials and Methods

A continuous infusion of 5FU plus leucovorin and radiotherapy (50.4 Gy) in 28 fractions was given each patient as CCRT. They underwent D2 radical resection with TME and ANP for the rectal cancer in 4 weeks.

Results

Thirty three patients had laparoscopic resection such as LAR, colo-anal anastomosis and APR. The results were compared with 12 cases of the conventional resections. As a result of preoperative CCRT, the cancer was down-staged in 71%. Two year disease free survival was 75% and 74% in the group of conventional and laparoscopic resection, respectively (p=0.427). Ileus, voiding difficulty and leakage after surgery were not different between two groups. Weakness of ejaculation was noted in 9~11% of both groups. The DFS of the preoperative CCRT followed by radical resection in the groups with a response was more favorable than that in the group with progressive or stable disease.

Conclusion

Radical resection of advanced distal rectal cancer could be done with performing a laparoscopic assisted operation after CCRT induced down-staging. We may suggest that laparoscopic assisted resection is a good treatment option as it doesn't increase the complications and it has a compatible survival rate to conventional surgery.

Citations

Citations to this article as recorded by

DPYD,TYMS,TYMP,TK1, andTK2Genetic Expressions as Response Markers in Locally Advanced Rectal Cancer Patients Treated with Fluoropyrimidine-Based Chemoradiotherapy
Ming-Yii Huang, Chan-Han Wu, Chun-Ming Huang, Fu-Yen Chung, Ching-Wen Huang, Hsiang-Lin Tsai, Chin-Fan Chen, Shiu-Ru Lin, Jaw-Yuan Wang
BioMed Research International.2013; 2013: 1. CrossRef

11,420 View
48 Download
1 Crossref

Complication of Intraoperative Radiation Therapy ( IORT ) Combined with External Irradiation and Chemotherapy in Gastric and Colorectal Cancer: Myung Se Kim, Seong Kyu Kim, Sun Kyo Song, Jae Hwang Kim, Hong Jin Kim, Min Chul Chim, Koing Bo Kwun, Heung Dae Kim; J Korean Cancer Assoc. 1994;26(1):16-24.

Abstract PDF: Although local recurrence is most troublesome problem even in early gastric and colorectal cancer, distant metastasis is the other cause of death among survivors. Department of Therapeutic Radiology & General Surgery in Yeungnam Medical Center tried prospective protocol which includes IORT and external irradiation for local control and various chemotherapy for systemic treatment since June 15, 1988. Total sixty eight patients(59 gastric, 9 colorectal) entered in our protocol. Fhysical examination, CBC, Chest X-Ray, and other biochemical examinations were performed on monthly basis, if it is necessary, CT, MRI and endoscopy were ordered. Sixty-one patients(53 gastric, 8 colorectal) were performed IORT(89.7%). Treatment related complications were found in 14 patients(23%) including 4 patients of gastro-intestinal bleedings (6.6%), 2 patients of bone marrow depressions(3.3%). 1 patient of perioperative abscess and sepsis(1.6%), 4 patients of intestinal obstructions(6.6%) and 4 patients of hand & leg edema(6.6%). Six of 14 patients with complications were dead(9.8%), probably due to complication. Our results are very encouraging, because only one patients with rectal cancer had local failure(1.6%) and complication rate is comparable with other published reports, in spite of our aggressive treatment. But reduced dose of chemotherapeutic agents, compromising of treatment sequence between chemotherapy and external irradiation and judicious perioperative care should be considered for further better results.

3,079 View
15 Download

The Effect of Ethanol on the Experimental Hepatocarcinogenesis Induced by 3'-methyl-4-dimethylaminoazobenzene: Hee Jeong Ahn, Charn Il Park; J Korean Cancer Assoc. 1994;26(1):24-41.

Abstract PDF: It has been generally accepted that sequential histological changes develop during the course of hepatocarcinogenesis as the precancerous lesions. However, the exact pathogenic mechanism and the relationship between these precancerous lesions and carcinoma remain contro- versiaL In 3'-methyl-4-dimethylaminoazobenzene(3'-MeDAB) induced hepatocarcinogenesis, the intermediate metabolites produced by cytochrome P, oxidase system of hepatocytes are thought to be the ultimate carcinogen, and conceivably such drugs as ethanol which is also oxidized by the same hepatic oxidase system may affect the 3-MeDAB induced hepatocarcinogenesis. The present study aimed to elucidate that the cytokinetic nature of the hepatic lesions developed by 3'-MeDAB administration and the effect of ethanol on the course of hepatocarcinogenesis. Sprague-Dawley male rats about 180 g were used for the experiment, and divided into 8 groups according to the duration and doses of 3-MeDAB and ethanol administered: I. normal control, IL 3-MeDAB only for 6 weeks, III. 3'-MeDAB only for 9 weeks, IV. 3'-MeDAB with a small dose(4 g/kg) of ethanol, V. 3'-MeDAB with a large dose(ll g/kg) of ehtanol, VL ethanol pretreatment for 3 weeks followed by 3'-MeDAB plus ethanol for 9 weeks, VII. Ethanol only for 9 weeks in a small dose, VIII. Ethanol only for 9 weeks in a large dose. Animals were sacrificed at 3, 6, 9, 12 and 15 weeks. The liver weight, the gross and microscopical changes of the liver were compered between the experimental groups. Cell kinetics of the various hepatic lesions developed in the hepatocarcinogenesis was examined by applying the immunohistochemical method for bromodeoxyuridine(BrdU). The results are as follows: 1) Liver weights tended to increase gradually in the experimental groups treated with 3'- MeDAB with or without ethanol, whereas it decreased in the animals given ethanoi alone. 2) The number and size of hepatic granules, nodules and masses continued to increaae in the

2,547 View
14 Download

Complications Following Pancreaticoduodenectomy: Hyuk Jai Jang, Sung Gyu Lee, Duck Jong Han, Hong Suck Joon, Kwang Min Park, Tae Won Kwon, Pyung Chul Min; J Korean Cancer Assoc. 1994;26(1):62-70.

Abstract PDF: Pancreaticoduodenectomy is a complex operation that previously carried high postoperative morbidity and mortality, but the operative mortality has decreased recently due to improvement in operative technique and perioperative care. This paper analyzes the postoperative complications after 64 pancreaticoduodenectomies performed during the past 3years and Gmonths from August, l989 to February, 1993 in the Department of Surgery, Asan Medical Center. 1) Postoperative major complications developed in 12 patients(l8.8%), including 3 intra-ab-dominal hemorrhage(4.7%), 3 gastrointestinal tract bleeding(4.7%), 3 intra-abdominal abscess (4.7% ), 2 pancreatic leakage(3.1%), and 1 bile leakage(1.6%). 2) The complications requiring relaparotomy in 3 patients(l intra-abdominal hemorrhage, 1 gastrointestinal tract bleeding, 1 Pancreatic leakage) ended fatally in 1 patient who died of gastrointestinal tract bleeding. Therefore, the overall martality rate was 1.6 percent. 3) A1though most complications could be managed conservatively, early reintervention should be done in dangerous complications such as uncontrolled pancreatic leaks and massive intraabdominal or gastrointestinal bleeding. 4) Based on our data, pancreaticoduodenectomy can be performed safely by experienced surgeons and can be used widely for suspicious periampullary tumorous lesions.

2,995 View
20 Download

Local Complications after Surgical Treatment for Thyroid carcinoma: Suk Hyung Kang, Ki Hoon Jung, Jeoung Won Bae; J Korean Cancer Assoc. 1996;28(1):88-94.

Abstract PDF: There is considerable controversy concerning the most appropriate surgica1 treatment of patients with differentiated thyroid cancer. This study was conducted to determine the op timal surgical operation by analysis of morbidity and mortality according to the operative method adopted. The clinical records were reviewed from 128 cases with thyroid cancer treated at the department of Surgery, Korea University Hospital. between January 1985 and December 1992. Local complications were defined as those occurring in the operative areas or as local results after the surgery during the hospitalization. Forty-five patients (35%) underwent total thyroidectomy, 30(23%) total thyroidectomy with radical lymph node dissection, 20(16%) subtotal thyroidectomy, and 33(26%) thyroid lobectomy. Nineteen patients(14.8%) experienced temporary local complications. Out of 19(14.8%) transient hypocalcemia, 1 case occurred after subtotal thyroidectomy and 18 cases after total thyroidectomy. Four cases(3%) of bleeding occured after various types of thyroidectomy(l case after lobectomy, 1 case after subtotal thyroidectomy, 2 cases after total thyroidectomy). One case of wound infection after lobectomy and one case of recurrent laryngeal nerve in jury after total thyroidectomy were also identified. There were no postoperative deaths. The most frequent morbidity was transient hypocalcemia following the total thyroidectomy. Although total thyroidectomy relatively induced more postoperative complications than other procedure, the temporary postoperative complications were less important. Our data suggest that total thyroidectomy could be considered as an operative treatment of the thyroid cancer.

3,394 View
15 Download

Comparison of Clinical Outcome in Para-aortic Lymph Node Dissection (PALD) and D2 for Advanced Gastric Cancer: Chan Dong Kim, Dae Hyun Yang, Ik Haeng Jo, Jin Pok Kim, Won Jin Choi, Il Myung Kim, Jin Youn, Sang Su Park, Byung Ook Yoo, Seung Ik Ahn, Sin Eun Choi; J Korean Cancer Assoc. 2000;32(5):844-851.

Abstract PDF: PURPOSE
We compared the clinical results of paraaortic lymph node dissection (PALD) with those of D2 to evaluate the survival gain and disadvantage of paraaortic lymph node dissection for advanced gastric cancer.
MATERIALS AND METHODS
We analysed the clinical data of 196 patients who underwent curative resection and D2 with or without paraaortic lymph node dissection (PALD or D2) for advanced gastric cancer from May 1990 to June 1999. The operative factors (operative time, the amounts of intraoperative transfusion and hospital stay), operative morbidity and mortality and 5 year survival rates were compared between D2 and PALD groups.
RESULTS
The operative time of subtotal gastrectomy was significantly longer in PALD group than D2 group. The operative morbidity rates were 9.2% in D2 group and 10.3% in PALD group. There were 3 operative mortalities in D2 group and none in PALD group. The 5 year survival rates (5YSR's) of stage IB, II, IIIA, IIIB, IV were 88.9%, 92.3%, 30.2%, 24.2%, 28.9% in D2 group and 93.3%, 75.5%, 61.0%, 0%, 0% in PALD group.
CONCLUSION
The paraaortic lymph node dissection was a rather safe procedure without significant increase of morbidity and mortality. There was no statistically significant difference in survival in any stage of this retrospective study with limited cases and follow-ups.

3,076 View
18 Download

First
Prev
Page of 1
Next
Last

Search