Cancer Research and Treatment

Original Article

Clinical Characteristics of Primary Peritoneal Carcinoma: Sang Young Roh, Sook Hee Hong, Yoon Ho Ko, Tae Hee Kim, Myung Ah Lee, Byoung Yong Shim, Jae Ho Byun, In Sook Woo, Jin Hyoung Kang, Young Seon Hong, Kyung Shik Lee; Cancer Res Treat. 2007;39(2):65-68. Published online June 30, 2007; DOI: https://doi.org/10.4143/crt.2007.39.2.65

Purpose

The goal of this study was to determine the clinical and therapeutic characteristics of women with a primary peritoneal carcinoma (PPC).

Materials and Methods

A retrospective clinical study was conducted to evaluate 22 women diagnosed with a PPC from 1993 to 2007 at the Hospitals of The Catholic University of Korea. Diagnoses were based on the Gynecologic Oncology Group criteria and clinical data. We collected patient clinicopathological data including age, presenting symptoms, pretreatment CA-125 values (U/ml), clinical stage (based on the FIGO stage), performance status (using the Eastern Cooperative Oncology Group scale), whether cytoreductive surgery was optimal or not, types of chemotherapy and response to treatment. We evaluated the clinical characteristics and response to treatment, time to treatment failure and overall survival.

Results

The median overall survival of all patients was 23.1 months. The estimated 3-year survival rate was 29% (SE, 13%). The response rate to first-line platinum-based chemotherapy was 79% and the median time to treatment failure was 9.9 months (95% confidence interval, 1.38~18.4 months). By univariate and multivariate analysis, performance status was the only significant factor associated with overall survival (p<0.05).

Conclusion

We evaluated the clinical characteristics and treatment response of patients with a primary peritoneal carcinoma. Our results showed that it is possible to achieve long-term survival in patients with PPC. A further clinical study is to need to establish clinical characteristics and treatment outcomes.

Citations

Citations to this article as recorded by

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Review Article

Testis Tumor: A Review of 42 Cases: In Cheol Hwang, Dong Jin Yoon, Sung Hyun Jeon, Cheol Su Kim, Sung Goo Chang, Sun Ju Lee; J Korean Cancer Assoc. 2001;33(2):178-182.

Abstract PDF: PURPOSE
This study was performed in order to evaluate the clinical characteristics, effect of treatment and prognosis in patients with testicular tumors.
MATERIALS AND METHODS
We retrospectively reviewed 42 patients with testicular tumor treated at our hospital. We analyzed the pathologic classification, clinical stage, preoperative tumor markers, treatment methods, clinical characteristics, and prognosis.
RESULTS
The histologic type was seminoma in 11, teratoma in 10, yolk sac tumor in 5, embryonal cell carcinoma in 4, mixed type in 8 and secondary neoplasm in 4. Clinically, 31 patients were stage I, 2 stage IIa, 2 stage IIb, 1 stage IIc, 6 stage IV. Following orchiectomy, 22 patients underwent surveillance, 12 chemotherapy, 4 radiation therapy, 1 retroperitoneal lymph node dissection (RPLND), 2 radiation plus chemotherapy, and 1 radiation plus chemotherapy and RPLND. The 10-year survival rate was 90.9% in the cases of seminoma. Similarly, the 10-year survival rate was 96.0% in the cases of non-seminomatous germ cell tumors (NSGCT).
CONCLUSION
In our study, patients with testicular tumor revealed an excellent survival rate. Testicular tumors are solid tumors that have a possibility of complete remission by additional chemotherapy or radiation following radical surgery. Therefore, early detection and aggressive treatment were mandatory.

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Original Articles

Clinicopathologic Charcteristics of Korean Non - Hodgkin's Lymphomas Based on REAL Classification: Yoon Koo Kang, Bong Seog Kim, Tae Won Kim, Mon Hee Ryu, Seung Sook Lee, Baek Yeol Ryoo, Tae You Kim, Young Hyuck Im, Kyoo Hyung Lee, Jooryung Huh, Dae Seog Heo, Yung Jue Bang, Chulwoo Kim, Jung Shin Lee, Byoung Kook Kim, Woo Kun Kim, Sang Hee Kim, Noe Kveong Kim; J Korean Cancer Assoc. 1999;31(4):641-652.

Abstract PDF: PURPOSE
Non-Hodgkins lymphoma (NHL) is recognized as not a single disease but a group of diseases heterogeneous in biology and clinical characteristics. Recently, a new pathologic classification system, the REAL classification, has been introduced into the clinic. Although REAL classification has tried to define the subtypes biologically more correctly, its clinical usefulness has not been established yet. A retrospective study was performed to define the clinical characteristics of Korean NHLs according to the REAL classification and to determine its clinical usefulness.
MATERIALS AND METHODS
Pathologies of NHLs managed at 3 major hospitals in Korea between 1989 and 1995 were reviewed with immunophenotyping to determine the pathologic subtypes according to REAL classification. Clinical characteristics at the presentation and treatment outcomes of the eligible patients were analyzed. To determine the differences from the NHLs in the western countries, data of Non-Hodgkins Lymphoma Classification Project (NHLCP) were also compared.
RESULTS
Total 802 cases were eligible for this study. Although it was similar to NHLCP study that B-cell subtypes were the majority and diffuse large B-cell lymphoma was the most common subtype, the proportion of T-cell subtypes were much higher in our patient population than in the western population. It was because peripheral T-cell lymphomas, angiocentric lymphoma in particular, were more common and follicular lymphomas were less common in our patients. Eleven common pathologic subtypes could be classified into 3 prognostic groups. Marginal zone B-cell lymphoma and lymphoplasmacytoid lymphoma of which 5-year overall survival rate (5-yOSR) were > 80% were classified in the good prognostic group. Precursor T-lymphoblastic lymphoma was classified in the poor prognostic group because its 5-yOSR was less than 30%. The other 9 subtypes were classified in the intermediate prognostic group with S-yOSR of 30-79%.
CONCLUSION
The clinical. character' tics and prognoses of Korean NHLs could be defined according to REAL classification. These information would be helpful for the clinicians in formulating treatment strategies of Korean NHLs according to REAL classification.

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A Clinical Study of 500 Cases of Breast Cancer: In Sik Park, Ja Yun Koo, Hy De Lee, Woo Hee Jung; J Korean Cancer Assoc. 1997;29(6):1061-1068.

Abstract PDF: PURPOSE
We investigated the clinical characteristics of breast cancers and its significance. MATERIAL AND METHOD: We evaluated the clinical characteristics of 500 women with breast cancer who were diagnosed and treated by one surgeon between March 1991 and August 1996.
RESULTS
The median age was 46.7 years and the most common age group was 40's. The presenting symptoms for most patients were palpable mass (75.2%) followed by abnormal mammographic findings (8.4%), pain (6.3%) and nipple discharges (4.7%), and the duration of symptoms was less than 1 month in 41.4%. Fifty three percent of the 500 cases had T2 lesion (size; 2 to 5 cm). With the increase of tumor size, overall and disease free survival rates (OS, DFS) were decreased. Surgical treatment consisted of modified radical mastectomy (52.8%) and partial mastectomy (33.6%) The most common stage was II (42.3%) and the early breast cancer (stage 0, I, II) was 388cases (78.1%) and the stage were inversely correlated with DFS and OS. The positivity of axillary lymph node was 39.3% and the number of the metastatic lymph nodes was inversely correlated with DFS and OS. The pathologic types were infiltrating ductal carcinoma (83.0%), ductal carcinoma in situ (12.8%), infiltrating lobular carcinoma (1.2%), lobular carcinoma in situ (0.4%) and Paget's disease (2.0%). ER positivity was 48.9% and PR 46.9%. ER positive patients showed survival benefit compared to ER negative patients. The common sites of distant metastases were lung, bone and liver.
CONCLUSIONS
Our patients with breast cancer were younger than those of western and showed the impacts on survival according to the lymph node status,tumor size.

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Age-related Clinical Characteristics and Outcome of Hepatic Resection Therapy in Hepatocellular Carcinoma Patients: Ok Ku Cho, Dong Sup Yoon, Sung Won Kwon, Hoon Sang Chi, Byung Ro Kim; J Korean Cancer Assoc. 1997;29(5):825-831.

Abstract PDF: PURPOSE
A retrospective clinical study of 213 patients who underwent curative resection due to hepatocellular carcinoma was performed in order to compare the mortality and survival rates of elderly patients with those of younger patients following the resection.
MATERIALS AND METHODS
All subjects underwent curative resection at Shinchon & Yongdong Severance Hospital between January 1985 to December 1994. The subjects were classified into three age groups: Group I (n=26) under 40, Group II (n=142) between 41 and 60, and Group III (n=45) over 60. Variables considered include sex, family history, accompanied diseases, Hbs Ag, -PF, Child classification, operative method, resection margin, number of mass, size of mass and gross-appearance were evaluated by X2-test (p=0.05). The one, three and five year survival rates were analysed in each group by the Kaplan- Meyer method and survival curves were compared by the log-rank test. A probability of <0.05 was accepted as significant.
RESULTS
The results showed that elderly patients have no significant differences from the younger patients in any of the variables considered including postoperative morbidity, survival rate and disease-free survival rate, except for the family history and positive Hbs Ag in which the elderly patients showed significantly lower values.
CONCLUSION
These results suggest that hepatocellular carcinoma in the aged can be treated in identical manner as in younger patients.

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Clinical Characteristics of Korean Breast Cancer According to the Pathologic Type: Jong Suck Lee, You Sah Kim; J Korean Cancer Assoc. 1994;26(1):70-82.

Abstract PDF: Clinical characteristics of 411 patients with breast cancer, who were seen between March of 1983 and February of 1993 at the Keimyung University Dongsan Hospital, were analysed ac- cording to their pathological classification. Those with incomplete medical records and with in- complete follow up were not included in this study. Pathological classification was made ac- cording the final pathological report at the time of biopsy or surgery. 1) Of 411 patients, 405 were female and six were male. The most common pathological type was invasive ductal carcinoma with 298 patients(73.58%), followed by medullary carcinoma (7.16%), lobular carcinoma(4.20%), Paget's disease(4.20%), mucinous carcinoma(3.21%), intraduc- tal carcinoma(2.72%), and other rare types. 2) Average age of the patients was 46.1 years and there was no significant difference in average ages among the different pathologic types except in the patients with secretory carcinoma. 3) The average duration of symptoms of the entire patients was seven months. 4) The average size of the tumors was 4.2 cm and there was no difference in the average sizes among the histologic types. 5) The hormone receptor was positive in 95 patients(53.4%) of 178 patients tested. In patients with invasive ductal carcinoma the positivity for the hormonal receptor was 54.9%. Nine of 10 patients with lobular carcinoma was positive for hormonal receptor but all of the seven patients with medullary carcinoma was hormone receptor negative. 6) Axillary lymph nodes were involved in 66.1% of the entire patients. Positive axillary nodes were found in 71.4% of patients with invasive ductal carcinoma, 76.5% with lobular carcinoma, 64.7% with Paget's disease and 55.2% with medullary carcinoma. 7) In the six male patients, invasive ductal carcinoma was found in three patients, intraductal carcinoma in one patient, papillary carcinoma in one patient, and hemangio- pericytoma in one patient. The patient with intraductal carcinoma was 39 years old but average age of the remaining 5 patients was 54.2% years.

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