Cancer Research and Treatment

Original Articles

Gastrointestinal Cancer

Double Tract Reconstruction Reduces Reflux Esophagitis and Improves Quality of Life after Radical Proximal Gastrectomy for Patients with Upper Gastric or Esophagogastric Adenocarcinoma: Xin Ji, Chenggen Jin, Ke Ji, Ji Zhang, Xiaojiang Wu, Ziyu Jia, Zhaode Bu, Jiafu Ji; Cancer Res Treat. 2021;53(3):784-794. Published online December 29, 2020; DOI: https://doi.org/10.4143/crt.2020.1064

Purpose
The aim of the present study was to compare the difference between double tract reconstruction and esophagogastrostomy.
Materials and Methods
Patients who underwent radical proximal gastrectomy with esophagogastrostomy or double tract reconstruction were included in this study.
Results
Sixty-four patients were included in this study and divided into two groups according to reconstruction method. The two groups were well balanced in perioperative safety and 3-year overall survival (OS). The rates of postoperative reflux esophagitis in the double tract reconstruction group and esophagogastrostomy group were 8.0% and 30.8%, respectively (p=0.032). Patients in the double tract reconstruction group had a better global health status (p < 0.001) and emotional functioning (p < 0.001), and complained less about nausea and vomiting (p < 0.001), pain (p=0.039), insomnia (p=0.003), and appetite loss (p < 0.001) based on the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire. Regarding the EORTC QLQ-STO22 questionnaire, patients in the double tract reconstruction group complained less about dysphagia (p=0.030), pain (p=0.008), reflux (p < 0.001), eating (p < 0.001), anxiety (p < 0.001), dry mouth (p=0.007), and taste (p=0.001). The multiple linear regression analysis showed that reconstruction method, postoperative complications, reflux esophagitis, and operation duration had a linear relationship with the global health status score.
Conclusion
Double tract reconstruction could better prevent reflux esophagitis and improve quality of life without scarifying perioperative safety or 3-year OS.

Citations

Citations to this article as recorded by

Function Preserving Gastrectomy and Quality of Life
Jeesun Kim, Hyuk-Joon Lee
Journal of Gastric Cancer.2025; 25(1): 247. CrossRef
Comparative study of clinical efficacy of laparoscopic proximal gastrectomy with double-channel anastomosis and tubular gastroesophageal anastomosis
Mian Wang, Li-Li Zhang, Gang Wang, Yong-Chang Miao, Tao Zhang, Lei Qiu, Gui-Da Fang, Feng Lu, Da-Lai Xu, Peng Yu
World Journal of Gastrointestinal Surgery.2025;[Epub] CrossRef
Comparison of the efficacy, safety and postoperative quality of life between modified side overlap anastomosis and double-tract anastomosis after laparoscopic proximal gastrectomy
Chu-Ying Wu, Wen-Jin Zhong, Kai Ye
Updates in Surgery.2024; 76(6): 2255. CrossRef
Study of Short-Term and Long-Term Outcomes Between Esophagogastrostomy and Double-Tract Reconstruction After Proximal Gastrectomy
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Comparative analysis of two digestive tract reconstruction methods in total laparoscopic radical total gastrectomy
Tian-Xiang Dong, Dong Wang, Qun Zhao, Zhi-Dong Zhang, Xue-Feng Zhao, Bi-Bo Tan, Yu Liu, Qing-Wei Liu, Pei-Gang Yang, Ping-An Ding, Tao Zheng, Yong Li, Zi-Jing Liu
World Journal of Gastrointestinal Surgery.2024; 16(4): 1109. CrossRef
Differences in glycemic trends due to reconstruction methods after proximal gastrectomy from the perspective of continuous glucose-monitoring
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Surgery Today.2024; 54(9): 1104. CrossRef
The Short‐Term and Long‐Term Outcomes of Laparoscopy‐Assisted Proximal Gastrectomy with Double‐Tract Reconstruction versus Laparoscopy‐Assisted Total Gastrectomy with Roux‐en‐Y Reconstruction for Adenocarcinoma of the Esophagogastric Junction: A Multicent
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Zi jian Wang, Zi yao Xu, Zi jie Huang, Li Li, Da Guan, Yun he Gao, Xin xin Wang
BMC Surgery.2024;[Epub] CrossRef
Short-term outcomes and quality of life of esophagogastrostomy versus the double-tract reconstruction after laparoscopic proximal gastrectomy
Yong Sun, Chao Chen, Lei Hou, Enhong Zhao
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Asian Journal of Surgery.2023; 46(10): 4196. CrossRef
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Tricia S. Lewis, YongDong Feng
Annals of Medicine and Surgery.2022; 79: 103879. CrossRef
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Gastrointestinal cancer

An Innovative Prognostic Model Based on Four Genes in Asian Patient with Gastric Cancer: Jiahui Chen, Anqiang Wang, Jun Ji, Kai Zhou, Zhaode Bu, Guoqing Lyu, Jiafu Ji; Cancer Res Treat. 2021;53(1):148-161. Published online August 31, 2020; DOI: https://doi.org/10.4143/crt.2020.424

Abstract PDF Supplementary Material PubReader ePub

Purpose
Gastric cancer (GC) has substantial biological differences between Asian and non-Asian populations, which makes it difficult to have a unified predictive measure for all people. We aimed to identify novel prognostic biomarkers to help predict the prognosis of Asian GC patients.
Materials and Methods
We investigated the differential gene expression between GC and normal tissues of GSE66229. Univariate, multivariate and Lasso Cox regression analyses were conducted to establish a four-gene-related prognostic model based on the risk score. The risk score was based on a linear combination of the expression levels of individual genes multiplied by their multivariate Cox regression coefficients. Validation of the prognostic model was conducted using The Cancer Genome Atlas (TCGA) database. A nomogram containing clinical characteristics and the prognostic model was established to predict the prognosis of Asian GC patients.
Results
Four genes (RBPMS2, RGN, PLEKHS1, and CT83) were selected to establish the prognostic model, and it was validated in the TCGA Asian cohort. Receiver operating characteristic analysis confirmed the sensitivity and specificity of the prognostic model. Based on the prognostic model, a nomogram containing clinical characteristics and the prognostic model was established, and Harrell’s concordance index of the nomogram for evaluating the overall survival significantly higher than the model only focuses on the pathologic stage (0.74 vs. 0.64, p < 0.001).
Conclusion
The four-gene-related prognostic model and the nomogram based on it are reliable tools for predicting the overall survival of Asian GC patients.

Citations

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