Cancer Research and Treatment

Original Article

Effects of Polymorphisms of Innate Immunity Genes and Environmental Factors on the Risk of Noncardia Gastric Cancer: Jeongseon Kim, Young Ae Cho, Il Ju Choi, Yeon-Su Lee, Sook-Young Kim, Jung-Ah Hwang, Soo-Jeong Cho, Myeong-Cherl Kook, Chan Gyoo Kim, Young-Woo Kim; Cancer Res Treat. 2013;45(4):313-324. Published online December 31, 2013; DOI: https://doi.org/10.4143/crt.2013.45.4.313

PURPOSE
Increasing evidence suggests that polymorphisms in innate immunity genes are associated with Helicobacter pylori-induced inflammation and may influence susceptibility in developing noncardia gastric cancer. Therefore, we investigate the effect of polymorphisms of innate immunity genes and interactions with environmental factors in the Korean population.
MATERIALS AND METHODS
We genotyped four polymorphisms of TLR2 (rs1898830), TLR4 (rs10983755 and rs10759932), and CD14 (rs2569190) in a case-control study of 487 noncardia gastric cancer patients and 487 sex- and age-matched healthy controls. Polytomous logistic regression models were used to detect the effects of genetic polymorphisms and environmental factors, which were stratified by the histological type of gastric cancer.
RESULTS
TLR4 rs10983755 A carriers were found to have higher risk of intestinal-type noncarida gastric cancer than G homozygotes (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.01 to 1.97), but other genetic variants showed no association with the risk of noncardia gastric cancer. Among H. pylori-positive participants, smokers carrying TLR4 rs10983755 A had a higher risk of intestinal-type gastric cancer than nonsmoking TLR4 rs10983755 G homozygotes (OR, 4.28; 95% CI, 2.12 to 8.64). In addition, compared with tap water, other drinking water sources during childhood were found to be associated with the elevated risk of intestinal-type gastric cancer, and these associations were slightly stronger among TLR4 rs10983755 A carriers.
CONCLUSION
The genetic polymorphisms of innate immunity genes are associated with the development of intestinal-type noncardia gastric cancer and these associations may differ in accordance to an exposure to certain environmental factors.

Citations

Citations to this article as recorded by

Association between Toll-like receptor 2 rs4696483 and rs1898830 polymorphisms and the risk of triple-negative breast cancer
Rabeb M. Ghali, Sonia Zaied, Amira Daldoul, Perizat Kanabekova, Wassim Y. Almawi
Gene.2024; 928: 148773. CrossRef
Pathomorphological Manifestations and the Course of the Cervical Cancer Disease Determined by Variations in the TLR4 Gene
Eglė Žilienė, Arturas Inčiūra, Rasa Ugenskienė, Elona Juozaitytė
Diagnostics.2023; 13(12): 1999. CrossRef
Ranking and Prioritizing Risk Factors for Gastric Cancer
Ali Reza Yusefi, Shima Bordbar, Gholamhossein Mehralian, Kamran Bagheri Lankarani, Mohammad Khammarnia, Zahra Kavosi, Peivand Bastani
The Open Public Health Journal.2023;[Epub] CrossRef
Common variants in toll-like receptor family genes and risk of gastric cancer: a systematic review and meta-analysis
Ayoub Al Othaim, Sulieman Ibraheem Shelash Al-Hawary, Hashem O. Alsaab, Sami G. Almalki, Mazin A. A. Najm, Ahmed Hjazi, Ali Alsalamy, Abbas Firras Almulla, Hamzeh Alizadeh
Frontiers in Genetics.2023;[Epub] CrossRef
Association between EPHA5 methylation status in peripheral blood leukocytes and the risk and prognosis of gastric cancer
Xu Han, Tianyu Liu, Jiabao Zhai, Chang Liu, Wanyu Wang, Chuang Nie, Qi Wang, Xiaojie Zhu, Haibo Zhou, Wenjing Tian
PeerJ.2022; 10: e13774. CrossRef
Alleviation of Huntington pathology in mice by oral administration of food additive glyceryl tribenzoate
Debashis Dutta, Moumita Majumder, Ramesh Kumar Paidi, Kalipada Pahan
Neurobiology of Disease.2021; 153: 105318. CrossRef
Demethylation of the RB1 promoter concomitant with reactivation of TET2 and TET3 impairs gastric carcinogenesis in K19-Wnt1/C2mE transgenic mice
Donghui Cao, Zhifang Jia, Yanhua Wu, Tongrong Su, Dan Zhao, Menghui Wu, Tetsuya Tsukamoto, Masanobu Oshima, Jing Jiang, Xueyuan Cao
Life Sciences.2020; 263: 118580. CrossRef
Genetic Variability as a Regulator of TLR4 and NOD Signaling in Response to Bacterial Driven DNA Damage Response (DDR) and Inflammation: Focus on the Gastrointestinal (GI) Tract
Evagelia Spanou, Polyxeni Kalisperati, Ioannis S. Pateras, Alexandros Papalampros, Alexandra Barbouti, Athanasios G. Tzioufas, Athanassios Kotsinas, Stavros Sougioultzis
Frontiers in Genetics.2017;[Epub] CrossRef
Increased deaths from gastric cancer in communities living close to waste landfills
Agostino Di Ciaula
International Journal of Environmental Health Research.2016; 26(3): 281. CrossRef
Correlation of Serum Levels of Endostatin with Tumor Stage in Gastric Cancer: A Systematic Review and Meta-Analysis
Zheng-Hua Wang, Zhi-Tu Zhu, Xu-Yang Xiao, Jin Sun
BioMed Research International.2015; 2015: 1. CrossRef
Pattern-Recognition Receptors and Gastric Cancer
Natalia CastaÃ±o-RodrÃguez, Nadeem O. Kaakoush, Hazel M. Mitchell
Frontiers in Immunology.2014;[Epub] CrossRef

12,618 View
62 Download
11 Crossref

First
Prev
Page of 1
Next
Last

Search