Purpose
Rates of women with breast cancer have increased rapidly in recent years in Vietnam, with over 10,000 new patients contracting the disease every year. This study was conducted to identify demographic, reproductive and lifestyle risk factors for breast cancer in Vietnam.
Materials and Methods
Breast density, demographic, reproductive and lifestyle data of 269 women with breast cancer and 519 age-matched controls were collected in the two largest oncology hospitals in Vietnam (one in the north and one in the south). Baseline differences between cases and controls in all women, premenopausal and postmenopausal women were assessed using chi-squared tests and independent t tests. Conditional logistic regressionwas used to derive odds ratios (OR) for factors that had statistically significant associations with breast cancer.
Results
Vietnamesewomenwith breast cancerwere significantly more likely to have a breast density > 75% (OR, 1.7), be younger than 14 years at first menstrual period (OR, 2.2), be postmenopausal (OR, 2.0), have less than three pregnancies (OR, 2.1), and have less than two babies (OR, 1.7). High breast density (OR, 1.6), early age at first menstrual period (OR, 2.6), low number of pregnancies (OR, 2.3), hormone use (OR, 1.8), and no physical activities (OR, 2.2) were significantly associated with breast cancer among premenopausal women, while breast density (OR, 2.0), age at first menstrual period (OR, 1.8), number of pregnancies (OR, 2.3), and number of live births (OR, 2.4) were the risk factors for postmenopausal women.
Conclusion
Breast density, age at first menarche, menopause status, number of pregnancies, number of babies born, hormone use and physical activitieswere significantly associatedwith breast cancer in Vietnamese women.
Citations
Citations to this article as recorded by
Attention-guided erasing for enhanced transfer learning in breast abnormality classification Adarsh Bhandary Panambur, Sheethal Bhat, Hui Yu, Prathmesh Madhu, Siming Bayer, Andreas Maier International Journal of Computer Assisted Radiology and Surgery.2025;[Epub] CrossRef
Comparative Analysis of Women’s Breast Cancer Survival Time at Three Selected Government Referral Hospitals in Ethiopia’s Amhara Region Using Parametric Shared Frailty Models Seid Fentaw, Anteneh Godana, Dawit Abathun, Dessie Melese Chekole Breast Cancer: Targets and Therapy.2024; Volume 16: 269. CrossRef
Systematic Review and Meta-Analysis of Lifestyle and Reproductive Factors Associated with Risk of Breast Cancer in Asian Women Boon Hong Ang, Soo-Hwang Teo, Weang-Kee Ho Cancer Epidemiology, Biomarkers & Prevention.2024; 33(10): 1273. CrossRef
Look how far we have come: BREAST cancer detection education on the international stage Phuong Dung (Yun) Trieu, Claudia R. Mello-Thoms, Melissa L. Barron, Sarah J. Lewis Frontiers in Oncology.2023;[Epub] CrossRef
Information Needs of Patients With Breast Cancer Undergoing Treatment in Vietnam and Related Determinants Nguyen Thi SON, Hsin-Tien HSU, Pham Thi Thu HUONG, Truong Quang TRUNG Journal of Nursing Research.2023; 31(2): e265. CrossRef
Family history and breast cancer risk for Asian women: a systematic review and meta-analysis Heran Wang, Robert J. MacInnis, Shuai Li BMC Medicine.2023;[Epub] CrossRef
Exploring the Mental Health Challenges of Women Diagnosed with Breast Cancer in Vietnam: A Qualitative Study Ngoc Nguyen Bao, Ngan Thu Tran, Chris Jenkins, Hoang Van Minh, Phuong Tran Bich, Helene Johansson Social Work in Public Health.2023; 38(5-8): 416. CrossRef
Development and Validation of a Novel PPAR Signaling Pathway-Related Predictive Model to Predict Prognosis in Breast Cancer Yingkun Xu, Dan Shu, Meiying Shen, Qiulin Wu, Yang Peng, Li Liu, Zhenrong Tang, Shun Gao, Yuan Wang, Shengchun Liu, Dawei Cui Journal of Immunology Research.2022; 2022: 1. CrossRef
Do lifestyle factors influence risk of breast cancer recurrence in Korean women?: a cross-sectional survey So-Jung Park, Hye-Ah Yeom Korean Journal of Women Health Nursing.2022; 28(2): 145. CrossRef
Menstrual and Reproductive Factors in Association With Breast Cancer Risk in Vietnamese Women: A Case-Control Study Oanh Thi Bui, Huong Thanh Tran, Sang Minh Nguyen, Tu Van Dao, Quang Vinh Bui, Anh Tuan Pham, Martha J. Shrubsole, Qiuyin Cai, Fei Ye, Wei Zheng, Hung Nguyen Luu, Thuan Van Tran, Xiao-Ou Shu Cancer Control.2022;[Epub] CrossRef
Risk Factors Associated with Breast Cancer among Women in Addis Ababa, Ethiopia: Unmatched Case–Control Study Lidia Tolessa, Endalew Gemechu Sendo, Negalign Getahun Dinegde, Assefa Desalew International Journal of Women's Health.2021; Volume 13: 101. CrossRef
Trends in breast cancer incidence in Ho Chi Minh City 1996–2015: A registry-based study Dung X. Pham, Thao-Quyen H. Ho, Tung D. Bui, Lan T. Ho-Pham, Tuan V. Nguyen, Mohammad R. Akbari PLOS ONE.2021; 16(2): e0246800. CrossRef
Mammographic densities of Aboriginal and non-Aboriginal women living in Australia’s Northern Territory Kriscia A. Tapia, Gail Garvey, Mark F. McEntee, Mary Rickard, Lorraine Lydiard, Patrick C. Brennan International Journal of Public Health.2019; 64(7): 1085. CrossRef
Cancers in Vietnam—Burden and Control Efforts: A Narrative Scoping Review Tung Pham, Linh Bui, Giang Kim, Dong Hoang, Thuan Tran, Minh Hoang Cancer Control.2019;[Epub] CrossRef
Determinants of breast cancer in Saudi women from Makkah region: a case-control study (breast cancer risk factors among Saudi women) Fatmah J. Alsolami, Firas S. Azzeh, Khloud J. Ghafouri, Mazen M. Ghaith, Riyad A. Almaimani, Hussain A. Almasmoum, Rwaa H. Abdulal, Wesam H. Abdulaal, Abdelelah S. Jazar, Sufyan H. Tashtoush BMC Public Health.2019;[Epub] CrossRef
Association of overweight and obesity with breast cancer during premenopausal period in Asia: A meta-analysis RicvanDana Nindrea, Teguh Aryandono, Lutfan Lazuardi, Iwan Dwiprahasto International Journal of Preventive Medicine.2019; 10(1): 192. CrossRef