Skip Navigation
Skip to contents

Cancer Res Treat : Cancer Research and Treatment

OPEN ACCESS

Search

Page Path
HOME > Search
1 "Taebum Lee"
Filter
Filter
Article category
Publication year
Authors
Funded articles
Original Article
The Prognostic Role of Mitotic Index in Hepatocellular Carcinoma Patients after Curative Hepatectomy
Sang Yun Ha, Misun Choi, Taebum Lee, Cheol-Keun Park
Cancer Res Treat. 2016;48(1):180-189.   Published online March 18, 2015
DOI: https://doi.org/10.4143/crt.2014.321
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
High proliferation rate is a hallmark of cancer. The mitotic index is a useful and simple method for analysis of cell proliferation. However, the practical utility of mitotic index as a predictor of prognosis in patients with hepatocellular carcinoma (HCC) has not been determined. Therefore, we examined mitotic index as a prognostic marker in HCC patients.
Materials and Methods
We counted the number of mitotic cells in 10 high-power fields of the tumor area on hematoxylin and eosin–stained slides representing 282 surgically resected HCCs. The highest number of mitotic cells was defined as the mitotic index.
Results
High mitotic index was observed in 127 of 282 HCCs. High mitotic index showed significant association with younger age, larger tumor size, higher Edmondson grade, microvascular invasion, major portal vein invasion, intrahepatic metastasis, higher American Joint Committee on Cancer (AJCC) T-stage, higher Barcelona Clinic Liver Cancer (BCLC) stage, higher alpha-fetoprotein level, hepatitis B virus etiology, and liver cirrhosis. Patients with high mitotic index had shorter disease-specific survival (DSS) (p < 0.001) and tended to have shorter recurrence-free survival (p=0.112). In subgroup analysis among patients with a larger tumor size, microvascular invasion, intrahepatic metastasis, higher AJCC T-stage, and higher BLCL stage, high mitotic index showed unfavorable influences on DSS (p=0.001, p=0.008, p=0.003, p=0.012, and p < 0.001, respectively). In addition, high mitotic index was an independent predictor of shorter DSS (p=0.004).
Conclusion
High mitotic index may be a novel predictor of DSS in patients with HCC and may have utility as an auxiliary prognostic factor in HCC.

Citations

Citations to this article as recorded by  
  • Hepatocellular carcinoma arising from ectopic liver tissue: a systematic review of the literature
    Sami Akbulut, Tevfik Tolga Sahin
    European Journal of Gastroenterology & Hepatology.2026; 38(3): 243.     CrossRef
  • Genotoxicity assessment of cardioprotective terbium hydroxide nanorods: A comprehensive in vitro and in vivo study
    Vishnu Sravan Bollu, Susheel Kumar Nethi, Sanchita Tripathy, Sunil Misra, Chitta Ranjan Patra
    Journal of Drug Delivery Science and Technology.2026; 121: 108273.     CrossRef
  • Association of TERT promoter mutations with early recurrence in hepatocellular carcinoma: a subgroup analysis in a Vietnamese cohort
    Hanh Thi Tuyet Ngo, Duy Duc Nguyen, Hoang Anh Vu, Thao Thi Phuong Doan, Minh-Xuan Dang, Phat Thi Hong Ho, Khoa Anh Luong
    BMC Cancer.2026;[Epub]     CrossRef
  • Optimization of Mitotic Index Quantification Using the Amnis ImageStream Imaging Flow Cytometer
    I. V. Kholodenko, K. N. Yarygin, Y. S. Kim
    Bulletin of Experimental Biology and Medicine.2025; 179(4): 556.     CrossRef
  • Multi-gradient permutation survival analysis identifies mitosis and immune signatures steadily associated with cancer patient prognosis
    Xinlei Cai, Yi Ye, Xiaoping Liu, Zhaoyuan Fang, Luonan Chen, Fei Li, Hongbin Ji
    eLife.2025;[Epub]     CrossRef
  • Prognostic Role of Mitotic Index in Hepatocellular Carcinoma: Potential Clinical Implications for Very Early Stage Disease
    Sangjoon Choi, Yoon Ah Cho, Sujin Park, Hyun Hee Koh, Boram Park, Kyunga Kim, Ju Dong Yang, Sang Yun Ha
    Journal of Hepatocellular Carcinoma.2025; Volume 12: 3077.     CrossRef
  • Targeting stroma and tumor, silencing galectin 1 treats orthotopic mouse hepatocellular carcinoma
    Tahereh Setayesh, Ying Hu, Farzam Vaziri, Xin Chen, Jinping Lai, Dongguang Wei, Yu-Jui Yvonne Wan
    Acta Pharmaceutica Sinica B.2024; 14(1): 292.     CrossRef
  • BCG as an Innovative Option for HCC Treatment: Repurposing and Mechanistic Insights
    Farzam Vaziri, Tahereh Setayesh, Ying Hu, Resmi Ravindran, Dongguang Wei, Yu‐Jui Yvonne Wan
    Advanced Science.2024;[Epub]     CrossRef
  • Photo-triggered caffeic acid delivery via psyllium polysaccharide- gellan gum-based injectable bionanogel for epidermoid carcinoma treatment
    Sirajunnisa Abdul Razack, Yeachan Lee, Sivakumar Bose, Hwarang Shin, Won-Kyo Jung, Hyun Wook Kang
    International Journal of Biological Macromolecules.2024; 267: 131166.     CrossRef
  • Prognostic Factors after Hepatectomy for Hepatocellular Carcinoma—The Importance of Pathological Immunophenotyping, the Steatohepatitic Subtype and the Impact of the Hepatic Pedicle Clamping
    Lorrane Viana, Rui Caetano Oliveira, Ricardo Martins, Henrique Alexandrino, Maria Augusta Cipriano, José Guilherme Tralhão
    Gastrointestinal Disorders.2024; 6(2): 402.     CrossRef
  • The prognostic role of mitosis index, stage and grade of endometrial cancer in Dr. Soetomo General Academic Hospital Surabaya, Indonesia, in 2018-2020
    Farida Umi Choviva, Willy Sandhika, Pungky Mulawardhana
    Majalah Obstetri & Ginekologi.2024; 32(2): 74.     CrossRef
  • miR-22 gene therapy treats HCC by promoting anti-tumor immunity and enhancing metabolism
    Ying Hu, Tahereh Setayesh, Farzam Vaziri, Xuesong Wu, Samuel T. Hwang, Xin Chen, Yu-Jui Yvonne Wan
    Molecular Therapy.2023; 31(6): 1829.     CrossRef
  • Pan-cancer evaluation of clinical value of mitotic network activity index (MNAI) and its predictive value for immunotherapy
    Xuanyu Mao, Yimeng Cai, Sarah Long, Jesus Perez-Losada, Jian-Hua Mao, Hang Chang
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Differential expression of “A Disintegrin and Metalloproteinase 10” in hepatocellular carcinoma and the noncancerous hepatic tissues: Contribution to HCV-promoted hepatocarcinogenesis
    AmalAbd El Hafez, BasemH Elesawy, HebaS E. I. Hany
    Indian Journal of Pathology and Microbiology.2023; 66(3): 517.     CrossRef
  • Hepatocellular Carcinoma's Characteristics in an Endemic Country: A Closer Examination of Tumor Grade and Microvascular Invasion
    Ignasia Andhini Retnowulan, Marini Stephanie, Nur Rahadiani, Ridho Ardhi Syaiful, Ening Krisnuhoni
    Siriraj Medical Journal.2023; 75(11): 817.     CrossRef
  • Dependence of the Ki67 Labelling Index of Selected Canine Tumours on Patient Age, Sex and Tumour Size
    Theresa C. Firsching, Kristina Dietert, Alexander Bartel, Marcus G. Doherr, Achim D. Gruber
    Journal of Comparative Pathology.2022; 193: 1.     CrossRef
  • CXCR2 inhibition enables NASH-HCC immunotherapy
    Jack Leslie, John B G Mackey, Thomas Jamieson, Erik Ramon-Gil, Thomas M Drake, Frédéric Fercoq, William Clark, Kathryn Gilroy, Ann Hedley, Colin Nixon, Saimir Luli, Maja Laszczewska, Roser Pinyol, Roger Esteban-Fabró, Catherine E Willoughby, Philipp K Hab
    Gut.2022; 71(10): 2093.     CrossRef
  • Utility of Serum Ki-67 as a Marker for Malignancy in Dogs
    Annkathrin Estaller, Martin Kessler, Axel Wehrend, Johannes Hirschberger, Stephan Neumann
    Animals.2022; 12(10): 1263.     CrossRef
  • Validation of ZMYND8 as a new treatment target in hepatocellular carcinoma
    Sangjoon Choi, Keun-Woo Lee, Hyun Hee Koh, Sujin Park, So-Young Yeo, Jae-Won Joh, Moon Seok Choi, Seok-Hyung Kim, Cheol-Keun Park, Sang Yun Ha
    Journal of Cancer Research and Clinical Oncology.2021; 147(12): 3517.     CrossRef
  • Bioinformatics Analysis Identifies Precision Treatment with Paclitaxel for Hepatocellular Carcinoma Patients Harboring Mutant TP53 or Wild-Type CTNNB1 Gene
    Jiunn-Chang Lin, Tsang-Pai Liu, Vivin Andriani, Muhammad Athoillah, Chih-Yang Wang, Pei-Ming Yang
    Journal of Personalized Medicine.2021; 11(11): 1199.     CrossRef
  • Inositol 1,4,5‑trisphosphate receptor type 3 is involved in resistance to apoptosis and maintenance of human hepatocellular carcinoma
    Marcone Dos Santos, Andressa França, Antônio Lima Filho, Rodrigo Florentino, Paulo Diniz, Fernanda Lemos, Carlos Gonçalves, Vitor Coelho, Cristiano Lima, Giselle Foureaux, Michael Nathanson, Paula Vidigal, M. Leite
    Oncology Letters.2021;[Epub]     CrossRef
  • Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis
    Amit Kumar Ram, Balasubramaniyan Vairappan, BH Srinivas
    World Journal of Gastroenterology.2020; 26(45): 7131.     CrossRef
  • Evaluation of the role of Notch1 expression in hepatic carcinogenesis with clinico-pathological correlation
    Heba Hany, Asem Shalaby, Wagdi Al Kashef, Wageha Kandil, Rehab-Allah Shahin, Hatem El-Alfy, Tarek Besheer, Raghda Farag, Mie Mohamed
    Pathology.2018; 50(7): 730.     CrossRef
  • Asialoglycoprotein receptor targeted delivery of doxorubicin nanoparticles for hepatocellular carcinoma
    Sandhya Pranatharthiharan, Mitesh D. Patel, Vinod C. Malshe, Vaishali Pujari, Ajit Gorakshakar, Manisha Madkaikar, Kanjaksha Ghosh, Padma V. Devarajan
    Drug Delivery.2017; 24(1): 20.     CrossRef
  • 19,116 View
  • 129 Download
  • 23 Web of Science
  • 24 Crossref
Close layer

Cancer Res Treat : Cancer Research and Treatment
Close layer
TOP