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Case Report
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Pleural Metastasis as Initial Presentation of Occult Gastric Cardia Cancer: A Possible Role of PET-CT in Diagnosis
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So Young Yoon, Jeong Hwan Kim, Wan Seop Kim, Hyun Woo Chung, Mark Hong Lee, Sung Yong Kim, Yo Han Cho
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Cancer Res Treat. 2014;46(4):415-418. Published online July 18, 2014
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DOI: https://doi.org/10.4143/crt.2013.068
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Abstract
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- We report on a case of malignant pleural effusion as initial metastatic presentation of occult gastric cardia cancer in a young woman. To the best of our knowledge, this is the first report of gastric adenocarcinoma metastasized to pleura as an initial presentation. Location of cardia and signet ring cell histology may contribute to the manifestation. Utilization of PET/CT was helpful for proper diagnosis. For patients with such distinct clinical presentations, it would be appropriate to consider gastric cancer as one of the possible primary sites.
Original Articles
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TGFbeta1 Effect on Survival of Anticancer Drug - resistant L1210 Sublines
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Sung Yong Kim, Kyung Sub Lee, Jae Ryong Kim, Jeong Hee Kim
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J Korean Cancer Assoc. 1998;30(5):1005-1013.
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Abstract
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- PURPOSE
The inhibitory effect of TGFbeta1 on survivals of L1210 and anticancer drug- resistant L1210 sublines was investigated and the gene expression of TGFbeta1 in these cells was examined.
MATERIALS AND METHODS
The survivals of L1210, adriamycin-resistant(L1210AdR), vincristine-resistant(L1210VcR) or cisplatin-resistant(L1210Cis) cells were measured by MTT assay after treatment of TGFbeta1. Northern analysis was performed for TGFbeta1 gene expression in L1210, L1210AdR, L1210VcR or L1210Cis.
RESULTS
There was no different survival ratio between two groups, control and TGFbeta1(10 ng/ml) treated groups in L1210 cells. However, the survival ratio of L1210AdR was 59% in TGFbeta1 treated group for 96 hours. The survival ratio of L1210VcR was 61% for 96 hours in TGFbeta1 treated group.
The survival ratio of L1210Cis was 40% for 96 hours in TGFbeta1 treated group. Expressions of TGFbeta1 gene in drug-resistant sublines were significantly decreased than that of L1210 cells.
CONCLUSION
Growth of anticancer drug-resistant L1210 sublines were inhibited by TGFbeta1 but not in L1210 cells.
So, it is suggested that TGFbeta1 gene expression may have a part in anticancer drug-resistance.
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Occult Breast Cancer Presenting as an Axillary Lymph Node
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Sung Yong Kim, Min Hyuk Lee, Kyung Bal Hur, So Yeung Jin
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J Korean Cancer Assoc. 1994;26(5):833-841.
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Abstract
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- Cancer of many organs may first manifest itself by regional lymph node metastasis. Examples include cervical nodes from the upper respiratory tract, supraclavicular nodes from the gastrointestinal tract and axillary nodes from the breast. Occult breast cancer presenting as an axillary lymph node is rare disease. Recently, authors experienced two cases of occult breast cancer presenting an an axillary lymph node. One patient was 40 year old female, and treated with left axillary lymph node dissection, radiation therapy to left breast and combination chemotherapy. She had 27 positive out of 31 axillary lymph node and was free of disease for 35 months. The other patient was 44 year old female, undertaken same management of right axilla and breast as the above patient. She had all 12 positive axillary lymph node, but developed breast cancer in the ipsilateral breast 6 months later and died from metastatic breast cancer 16 months after surgery. We reported two cases of occult breast cancer.presenting as an axillary lymph node with review of literature.
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Reversal Effect of Antihistamines on Multidrug Resistance in Adriamycin - and Vincristine - resistant L1210 Variants
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Jae Ryong Kim, Sung Yong Kim, Jeong Hee Kim
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J Korean Cancer Assoc. 1995;27(1):130-138.
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Abstract
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- Intrinsic or acquired antitumordrug resistance in cancer cells is one of the major obstacles in cancer chemotherapy. Especially multidrug resistance(MDR) refers to the phenomenon where-by cells previously exposed to a single drug become resistant, simultaneously, to a range of structually and functionally unrelated agents. It is very important to overcome the drug- resistance in cancer cells for the success of chemotherapy. In order to isolate an effective chemasensitizer to overcome the drug resistance, we exam- ined the reversal effects of nine antihistamines on multidrug resistance in an adriamycin or a vincristine-resistant L1210(L1210AdR or L1210VcR) sublines, which show typical multidrug resistant phenotypes. The in vitro partial restoration of adriamycin sensitivity in L1210AdR by treatment of nontoxic doses of antihistamines was observed in astemizole, buclizine, megitazine, cetirizine, and terfenadine, in the order of their effectiveness(high to low). The sensitivity of L1210AdR to adriamycin was enhanced 13 fold when 1 uM of astemizole was present, and 8 fold in the presence of 30 uM buclizine. Astemizole and buclizine enhanced also the sensitivity to vinblastine(1160 fold and 933 fold), dactinomycin(complete reversal and 9 fold), or vinblastine (30 fold and 5 fold) in L1210AdR. However, the sensitivity to the same drugs in Ll210VcR was slightly increased in the presence af 1 uM astemizole or 30 uM buclizine. From these results, astemizole or buclizine may be used as a chemosensitizer during cancer chemotherapy. The mechanism by which astemizole or buclizine can reverse the drug resistance in L1210AdR or L1210VcR will be studied.
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Effect of Hyperthermia on Anticancer Drug - Resistant L1210 Sublines
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Jeong Hee Kim, Sung Yong Kim, Jae Ryong Kim
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J Korean Cancer Assoc. 1996;28(4):646-655.
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Abstract
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- The development of multidrug-resistant tumor cell populations is a major problem in the chemotheraphy of human cancer. These cells are often cross resistant to unrelated drugs. Current understanding of the mechanism of development of tumor drug resistance and its reversal, however, is limited. The present study was examined about sensitive Ll210 cell and resistant sublines (L1210AdR, L1210VcR and L1210Cis) for reversal of drug resistance by hyperthermia. Cell survival was determined by MTT assay after exposure to various heat(41, 42, 43¡ÆC) condition and to anticancer drug and heat combination. Survival rate of sensitive and resistant cells as various temperature exposure was revealed fifty percent on 42.8¡ÆC for L1210 cell and 41.4¡ÆC to 41.9¡ÆC for resistant sublines. The 50 percent survival for exposure times on 42¡ÆC was expressed as no change in L1210 cell and as 46 to 48 minutes on resistant cells, on 43¡ÆC, L1210 cell was 48 minutes, resistant cells were 10 to 14 minutes. Cytotoxicity of resistant sublines treated by combination of hyperthermia and adriamycin was not increased. mdr 1 gene of L1210AdR and L1210VcR were well expressed by hyperthermia but expression of hsp 70 gene were increased to compare increasing of exposure time at 41¡ÆC. Expressions of hsP 70 in L1210 and Ll210Cis cells were revealed the peak values at exposure for 45 min and 30 min. The cytotoxic effect of hyperthermia on resistant sublines were more effective than on sensitive L1210 cell. And then the suggestion of correlation between mdr 1 and hsp 70 gene brought about.
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