Cancer Research and Treatment

Original Article

Clinical Implication of Concordant or Discordant Genomic Profiling between Primary and Matched Metastatic Tissues in Patients with Colorectal Cancer: Jung Yoon Choi, Sunho Choi, Minhyeok Lee, Young Soo Park, Jae Sook Sung, Won Jin Chang, Ju Won Kim, Yoon Ji Choi, Jin Kim, Dong-Sik Kim, Sung-Ho Lee, Junhee Seok, Kyong Hwa Park, Seon Hahn Kim, Yeul Hong Kim; Cancer Res Treat. 2020;52(3):764-778. Published online February 16, 2020; DOI: https://doi.org/10.4143/crt.2020.044

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Purpose
The purpose of this study was to identify the concordant or discordant genomic profiling between primary and matched metastatic tumors in patients with colorectal cancer (CRC) and to explore the clinical implication.
Materials and Methods
Surgical samples of primary and matched metastatic tissues from 158 patients (335 samples) with CRC at Korea University Anam Hospital were evaluated using the Ion AmpliSeq Cancer Hotspot Panel. We compared genetic variants and classified them as concordant, primary-specific, and metastasis-specific variants. We used a combination of principal components analysis and clustering to find genomic groups. Kaplan-Meier curves were used to appraise survival between genomic groups. We used machine learning to confirm the correlation between genetic variants and metastatic sites.
Results
A total of 282 types of deleterious non-synonymous variants were selected for analysis. Of a total of 897 variants, an average of 40% was discordant. Three genomic groups were yielded based on the genomic discrepancy patterns. Overall survival differed significantly between the genomic groups. The poorest group had the highest proportion of concordant KRAS G12V and additional metastasis-specific SMAD4. Correlation analysis between genetic variants and metastatic sites suggested that concordant KRAS mutations would have more disseminated metastases.
Conclusion
Driver gene mutations were mostly concordant; however, discordant or metastasis-specific mutations were present. Clinically, the concordant driver genetic changes with additional metastasis-specific variants can predict poor prognosis for patients with CRC.

Citations

Citations to this article as recorded by

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Heather Johnson, Zahra El-Schich, Amjad Ali, Xuhui Zhang, Athanasios Simoulis, Anette Gjörloff Wingren, Jenny L. Persson
Cancers.2022; 14(8): 2045. CrossRef
Putative anoikis resistant subpopulations are enriched in lymph node metastases and indicate adverse prognosis in colorectal carcinoma
Taneli T. Mattila, Madhura Patankar, Juha P. Väyrynen, Kai Klintrup, Jyrki Mäkelä, Anne Tuomisto, Pentti Nieminen, Markus J. Mäkinen, Tuomo J. Karttunen
Clinical & Experimental Metastasis.2022; 39(6): 883. CrossRef
Clinical Application of Targeted Deep Sequencing in Metastatic Colorectal Cancer Patients: Actionable Genomic Alteration in K-MASTER Project
Youngwoo Lee, Soohyeon Lee, Jae Sook Sung, Hee-Joon Chung, Ah-reum Lim, Ju Won Kim, Yoon Ji Choi, Kyong Hwa Park, Yeul Hong Kim
Cancer Research and Treatment.2021; 53(1): 123. CrossRef
Comparison of metastatic castration-resistant prostate cancer in bone with other sites: clinical characteristics, molecular features and immune status
Zhengquan Xu, Yanhong Ding, Wei Lu, Ke Zhang, Fei Wang, Guanxiong Ding, Jianqing Wang
PeerJ.2021; 9: e11133. CrossRef
High Concordance of Genomic Profiles between Primary and Metastatic Colorectal Cancer
Seung Eun Lee, Ha Young Park, Dae-Yong Hwang, Hye Seung Han
International Journal of Molecular Sciences.2021; 22(11): 5561. CrossRef
Comprehensive Imaging Characterization of Colorectal Liver Metastases
Drew Maclean, Maria Tsakok, Fergus Gleeson, David J. Breen, Robert Goldin, John Primrose, Adrian Harris, James Franklin
Frontiers in Oncology.2021;[Epub] CrossRef

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Review Article

Robotic Surgery for Rectal Cancer: An Update in 2015: Jung Myun Kwak, Seon Hahn Kim; Cancer Res Treat. 2016;48(2):427-435. Published online February 3, 2016; DOI: https://doi.org/10.4143/crt.2015.478

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During the last decade, robotic surgery for rectal cancer has rapidly gained acceptance among colorectal surgeons worldwide, with well-established safety and feasibility. The lower conversion rate and better surgical specimen quality of robotic compared with laparoscopic surgery potentially improves survival. Earlier recovery of voiding and sexual function after robotic total mesorectal excision is another favorable outcome. Long-term survival data are sparse with no evidence that robotic surgery offers major benefits in oncological outcomes. Although initial reports are promising, more rigorous scientific evaluation in multicenter, randomized clinical trials should be performed to definitely determine the advantages of robotic rectal cancer surgery.

Citations

Citations to this article as recorded by

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Mahmood Al-Dhaheri, Ibrahim Amer, Noof AL. Naimi, Amjad Parvaiz
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Karyn B. Stitzenberg, Emilie Barnes
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Original Articles

Surgical treatment of periampullary cancer: Seon Hahn Kim, Sae Min Kim; J Korean Cancer Assoc. 1992;24(2):306-313.

Abstract PDF: No abstract available.

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Comparison of PCNA Index between Cancer , Normal Mucosa and Intestinal Metaplasia Around the Gastric Cacner: Jae Bok Lee, Han Kyeum Kim, Seon Hahn Kim, Young Jae Mok, Young Chul Kim, Bum Hwan Koo, Sae Min Kim; J Korean Cancer Assoc. 1996;28(4):639-646.

Abstract PDF: Due to the poor prognosis of advanced gastric cancer, it is well acknowledged that early diagnosis is the most important goal in the approach to gastric cancer. In 1970 Corres et al. reported that a close correlation existed between the occurrence rate of gastric cancer and the prevalence rate of chronic atrophic gastritis or intestinal metaplasia of the gastric mucosa. The purpose of this study is to define the significance of intestinal metaplasia as a precancerous lesion by comparing the proliferative potentials of intestinal metaplasia with that of cancer tissue and normal gastric mucosal tissue. This was accomplished immunohistochemically by measuring and comparing the amount of PCNA protein found in the cancerous tissue, intestinal metaplastic lesions and normal mucosa from the resected samples of gastric cancer patients. We examined resected samples of 86 gastric cancer patients who had been operated on between July 25 and September 23 of 1992, and selected samples of 89 cancerous tissue, 60 intestinal metaplasia tissue and 60 normal mucosa. Each tumor sample was investigated on the histological classification(WHO, Lauren, and Ming classification), degree of mucosal invasion, existence of tumor thrombus and degree of differentiation. PCNA staining was made according to Streptavidin-biotin method. The number of stained cells converted to the percentage of the total number of cells was defined as the PCNA labeling index(LI). Statistical analysis was performed with the Student t-test and ANOVA test by SAS program. Overall, there was no significant difference between the PCNA index of cancer(l6.0%) and intestinal metaplasia(12.6%) with p=0.055, but a significant difference existed between intestinal metaplasia and normal mucosa with an index of 12.6% and 7.42%, respectively(p =0.013). There were na significant differences found between early and advanced cancer(p =0.620). PCNA index was higher with lymph node metastasis than without metastasis in advanced gastric cancer(p=0.009). There were no differences in the LI value in degree of differentiation, tumor thrombi or the Lauren and Ming classifications(p>0.05). PCNA index was higher in the middle and lower zone of the glands of the intestinal metaplasia than normal mucosa. (p=0.001)From the current results, the proliferation potential of peritumoral intestinal metaplasia was found to be higher than normal tissue, and we believe that this lesion should be investigated further as a precancerous lesion. Also, we find the PCNA labeling index to be a useful method as an objective guide for these further investigations.

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Acinar Cell Carcinoma in a Pancreas : Report of a recurrent case: Eun Sook Lee, Ki Hoon Jung, Nam Ryul Kim, Seon Hahn Kim, Sae Min Kim, Chul Hwan Kim; J Korean Cancer Assoc. 1996;28(4):782-787.

Abstract PDF: Acinar cell carcinoma of the pancreas is a rare neoplasm arising from the exocrine cells of the pancreas, comprising no more than 1 to 2% of all pancreatic cancers. CT appearence of pancreatic acinar carcinoma has been described as a sharply circumscribed mass with central necrosis. We report a case of recurrent acinar cell carcinoma of the pancreas in a 41-year-old man who had distal pancreatectomy three years ago for primary acinar cell carcinoma.

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