The paraneoplastic neurologic diseases (PNDs) are brain degenerations that develop in the setting of clinically inapparent cancers. PNDs arise when common cancers express brain proteins, triggering an anti-tumor immune response and tumor immunity. Research on these brain-cancer proteins has revealed a new world of neuron-specific RNA binding proteins whose functions may be aberrantly used by tumor cells. Efforts to gain insight into their function has led to the development of new methods and strategies to understand RNA protein regulation in living tissues.

Citations

Citations to this article as recorded by  

• Post‐Transcriptional Regulation of Gene Expression and the Intricate Life of Eukaryotic mRNAs
  Carly L. Lancaster, Kenneth H. Moberg, Anita H. Corbett
  WIREs RNA.2025;[Epub]     CrossRef
• Identifying the mitochondrial ribosomal protein MRPL13 as an oncogenic RBP that promotes proliferation, migration, and anti-apoptotic effects in esophageal cancer cells
  Yaxi Song, Hui Wang, Shiyao Li, Weili Tao, Chunqing Li, Bin Wang, Caifeng Gong
  Heliyon.2024; : e39546.     CrossRef
• LARP6 suppresses colorectal cancer progression through ZNF267/SGMS2-mediated imbalance of sphingomyelin synthesis
  Xiaoli Long, Xunhua Liu, Ting Deng, Jianxiong Chen, Jiawen Lan, Sijing Zhang, Miao Zhou, Dan Guo, Jun Zhou
  Journal of Experimental & Clinical Cancer Research.2023;[Epub]     CrossRef
• Effect and mechanism of circRNAs in tumor angiogenesis and clinical application
  Luyang Zhao, Yuying Guo, Yaxin Guo, Xiang Ji, Dandan Fan, Chen Chen, Weitang Yuan, Zhenqiang Sun, Zhenyu Ji
  International Journal of Cancer.2022; 150(8): 1223.     CrossRef
• Widespread autogenous mRNA–protein interactions detected by CLIP-seq
  Thomas H Kapral, Fiona Farnhammer, Weihao Zhao, Zhi J Lu, Bojan Zagrovic
  Nucleic Acids Research.2022; 50(17): 9984.     CrossRef
• Computational tools to study RNA-protein complexes
  Sneha Bheemireddy, Sankaran Sandhya, Narayanaswamy Srinivasan, Ramanathan Sowdhamini
  Frontiers in Molecular Biosciences.2022;[Epub]     CrossRef
• RNA Regulators in Leukemia and Lymphoma
  Camila Prieto, Michael G. Kharas
  Cold Spring Harbor Perspectives in Medicine.2020; 10(5): a034967.     CrossRef
• Diverse roles of RNA‐binding proteins in cancer traits and their implications in gastrointestinal cancers
  Kiyoshi Masuda, Yuki Kuwano
  WIREs RNA.2019;[Epub]     CrossRef
• MOV10 binding circ-DICER1 regulates the angiogenesis of glioma via miR-103a-3p/miR-382-5p mediated ZIC4 expression change
  Qianru He, Lini Zhao, Xiaobai Liu, Jian Zheng, Yunhui Liu, Libo Liu, Jun Ma, Heng Cai, Zhen Li, Yixue Xue
  Journal of Experimental & Clinical Cancer Research.2019;[Epub]     CrossRef
• KHDRBS3 regulates the permeability of blood–tumor barrier via cDENND4C/miR-577 axis
  Peiqi Wu, Yang Gao, Shuyuan Shen, Yixue Xue, Xiaobai Liu, Xuelei Ruan, Lianqi Shao, Yunhui Liu, Ping Wang
  Cell Death & Disease.2019;[Epub]     CrossRef
• IDH1 fine-tunes cap-dependent translation initiation
  Lichao Liu, J Yuyang Lu, Fajin Li, Xudong Xing, Tong Li, Xuerui Yang, Xiaohua Shen, Zefeng Wang
  Journal of Molecular Cell Biology.2019; 11(10): 816.     CrossRef
• Expanding horizons: new roles for non-canonical RNA-binding proteins in cancer
  Samantha Moore, Aino I Järvelin, Ilan Davis, Gareth L Bond, Alfredo Castello
  Current Opinion in Genetics & Development.2018; 48: 112.     CrossRef
• Graphene Oxide-Facilitated Comprehensive Analysis of Cellular Nucleic Acid Binding Proteins for Lung Cancer
  Zhi Shang, Liqiang Qian, Sha Liu, Xiaomin Niu, Zhi Qiao, Yan Sun, Yan Zhang, Liu-Yin Fan, Xin Guan, Cheng-Xi Cao, Hua Xiao
  ACS Applied Materials & Interfaces.2018; 10(21): 17756.     CrossRef
• NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer
  Andrew T. Ludlow, Mandy Sze Wong, Jerome D. Robin, Kimberly Batten, Laura Yuan, Tsung-Po Lai, Nicole Dahlson, Lu Zhang, Ilgen Mender, Enzo Tedone, Mohammed E. Sayed, Woodring E. Wright, Jerry W. Shay
  Nature Communications.2018;[Epub]     CrossRef
• Identification and Analysis of Key Residues in Protein–RNA Complexes
  A. Kulandaisamy, Ambuj Srivastava, Pradeep Kumar, R. Nagarajan, S. Binny Priya, M. Michael Gromiha
  IEEE/ACM Transactions on Computational Biology and Bioinformatics.2018; 15(5): 1436.     CrossRef
• RNA Binding Protein as an Emerging Therapeutic Target for Cancer Prevention and Treatment
  Suntaek Hong
  Journal of Cancer Prevention.2017; 22(4): 203.     CrossRef
• The expanding universe of ribonucleoproteins: of novel RNA-binding proteins and unconventional interactions
  Benedikt M. Beckmann, Alfredo Castello, Jan Medenbach
  Pflügers Archiv - European Journal of Physiology.2016; 468(6): 1029.     CrossRef
• NOVA2-mediated RNA regulation is required for axonal pathfinding during development
  Yuhki Saito, Soledad Miranda-Rottmann, Matteo Ruggiu, Christopher Y Park, John J Fak, Ru Zhong, Jeremy S Duncan, Brian A Fabella, Harald J Junge, Zhe Chen, Roberto Araya, Bernd Fritzsch, A J Hudspeth, Robert B Darnell
  eLife.2016;[Epub]     CrossRef
• Identifying proteins that bind to specific RNAs - focus on simple repeat expansion diseases
  Magdalena Jazurek, Adam Ciesiolka, Julia Starega-Roslan, Katarzyna Bilinska, Wlodzimierz J. Krzyzosiak
  Nucleic Acids Research.2016; : gkw803.     CrossRef
• UNR/CSDE1 Drives a Post-transcriptional Program to Promote Melanoma Invasion and Metastasis
  Laurence Wurth, Panagiotis Papasaikas, David Olmeda, Nadine Bley, Guadalupe T. Calvo, Santiago Guerrero, Daniela Cerezo-Wallis, Javier Martinez-Useros, María García-Fernández, Stefan Hüttelmaier, Maria S. Soengas, Fátima Gebauer
  Cancer Cell.2016; 30(5): 694.     CrossRef
• Tumor-promoting function and prognostic significance of the RNA-binding protein T-cell intracellular antigen-1 in esophageal squamous cell carcinoma
  Junichi Hamada, Katsutoshi Shoda, Kiyoshi Masuda, Yuji Fujita, Takuya Naruto, Tomohiro Kohmoto, Yuko Miyakami, Miki Watanabe, Yasusei Kudo, Hitoshi Fujiwara, Daisuke Ichikawa, Eigo Otsuji, Issei Imoto
  Oncotarget.2016; 7(13): 17111.     CrossRef
• RNA-binding proteins, multifaceted translational regulators in cancer
  Laurence Wurth, Fátima Gebauer
  Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms.2015; 1849(7): 881.     CrossRef
• RNA-binding proteins in neurological diseases
  HuaLin Zhou, Marie Mangelsdorf, JiangHong Liu, Li Zhu, Jane Y Wu
  Science China Life Sciences.2014; 57(4): 432.     CrossRef
• A versatile assay for RNA-binding proteins in living cells
  Claudia Strein, Anne-Marie Alleaume, Ulrich Rothbauer, Matthias W. Hentze, Alfredo Castello
  RNA.2014; 20(5): 721.     CrossRef
• RNA-binding proteins in Mendelian disease
  Alfredo Castello, Bernd Fischer, Matthias W. Hentze, Thomas Preiss
  Trends in Genetics.2013; 29(5): 318.     CrossRef
• Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins
  Alfredo Castello, Bernd Fischer, Katrin Eichelbaum, Rastislav Horos, Benedikt M. Beckmann, Claudia Strein, Norman E. Davey, David T. Humphreys, Thomas Preiss, Lars M. Steinmetz, Jeroen Krijgsveld, Matthias W. Hentze
  Cell.2012; 149(6): 1393.     CrossRef
• Alternative splicing interference by xenobiotics
  Emanuela Zaharieva, J. Kevin Chipman, Matthias Soller
  Toxicology.2012; 296(1-3): 1.     CrossRef
• Neural antigen‐specific autoimmune disorders
  Raffaele Iorio, Vanda A. Lennon
  Immunological Reviews.2012; 248(1): 104.     CrossRef
• Paraneoplastic encephalomyelopathies: pathology and mechanisms
  Andrew McKeon, Sean J. Pittock
  Acta Neuropathologica.2011; 122(4): 381.     CrossRef