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Original Article
- Lung Cancer
- Inhibition of lncRNA KCNQ1OT1 Improves Apoptosis and Chemotherapy Drug Response in Small Cell Lung Cancer by TGF-β1 Mediated Epithelial-to-Mesenchymal Transition
- Deyu Li, Qin Tong, Yuane Lian, Zhizhong Chen, Yaru Zhu, Weimei Huang, Yang Wen, Qiongyao Wang, Shumei Liang, Man Li, Jianjing Zheng, Zhenhua Liu, Huanxin Liu, Linlang Guo
- Cancer Res Treat. 2021;53(4):1042-1056. Published online March 9, 2021
- DOI: https://doi.org/10.4143/crt.2020.1208
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Abstract
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Supplementary Material
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ePub - Purpose
Drug resistance is one of the main causes of chemotherapy failure in patients with small cell lung cancer (SCLC), and extensive biological studies into chemotherapy drug resistance are required.
Materials and Methods
In this study, we performed lncRNA microarray, in vitro functional assays, in vivo models and cDNA microarray to evaluate the impact of lncRNA in SCLC chemoresistance.
Results
The results showed that KCNQ1OT1 expression was upregulated in SCLC tissues and was a poor prognostic factor for patients with SCLC. Knockdown of KCNQ1OT1 inhibited cell proliferation, migration, chemoresistance and promoted apoptosis of SCLC cells. Mechanistic investigation showed that KCNQ1OT1 can activate transforming growth factor-β1 mediated epithelial-to-mesenchymal transition in SCLC cells.
Conclusion
Taken together, our study revealed the role of KCNQ1OT1 in the progression and chemoresistance of SCLC, and suggested KCNQ1OT1 as a potential diagnostic and prognostic biomarker in SCLC clinical management. -
Citations
Citations to this article as recorded by
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Journal of Translational Medicine.2024;[Epub] CrossRef - Non-coding RNAs in lung cancer: molecular mechanisms and clinical applications
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Frontiers in Oncology.2023;[Epub] CrossRef - Biological role of long non-coding RNA KCNQ1OT1 in cancer progression
Kai Zhan, Huafeng Pan, Zhang Zhou, Wenqian Tang, Zhining Ye, Shaogang Huang, Lei Luo
Biomedicine & Pharmacotherapy.2023; 169: 115876. CrossRef - Non-coding genome in small cell lung cancer between theoretical view and clinical applications
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Seminars in Cancer Biology.2022; 86: 237. CrossRef - KCNQ1OT1: An Oncogenic Long Noncoding RNA
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Biomolecules.2021; 11(11): 1602. CrossRef
- Molecular mechanism of ZC3H13 -mediated ferroptosis in doxorubicin resistance of triple negative breast cancer
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