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Original Articles
- Gynecologic cancer
- Plasma Cell-Free DNA in Uterine Cervical Cancer: Therapeutic Monitoring and Prognostic Values after Radical Radiotherapy
- Jae Sik Kim, Sunah Yang, Kyeonghun Jeong, Dong-Yun Kim, Kwangsoo Kim, Hyun-Cheol Kang
- Cancer Res Treat. 2023;55(2):659-670. Published online December 12, 2022
- DOI: https://doi.org/10.4143/crt.2022.1440
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Abstract
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Supplementary Material
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ePub - Purpose
In the present study, we aimed to establish a liquid biopsy-based monitoring method using peripheral blood cell-free DNA (cfDNA) for patients with cervical cancer who underwent radical radiotherapy (RT).
Materials and Methods
Twenty-five patients with cervical cancer were prospectively recruited and treated with external beam RT and brachytherapy. In all patients, except one, chemotherapy was administered concurrently during RT. Whole peripheral blood samples were obtained at least twice from each patient. We performed next-generation sequencing (NGS) for the target-captured libraries (67 oncogenes and human papillomavirus [HPV] type 16/18) using 64 plasma cfDNA samples from the 25 participants. The ratio of HPV cfDNA and the variant allele frequency (VAF) in cfDNA was calculated, and their dynamic changes were monitored. The median follow-up duration was 25.4 months.
Results
In total, we identified 21,866 cfDNA variants. ARID1A and frameshift variants occupied the largest portion of altered genes and HIGH-grade variant types, respectively. In most cases, tumor shrinkage was followed by a decrease in the HPV ratio; however, an increase in HPV ratio indicated distant metastasis, despite the reduced tumor size. The initial HPV ratio reflecting the tumor burden was likely associated with treatment outcomes (p = 0.16). We did not determine a role for serial changes in the VAF in cfDNA.
Conclusion
Our findings suggest that the HPV cfDNA ratio, calculated after targeted NGS, may be valuable for monitoring and predicting treatment responses. Accordingly, further validation of these findings is warranted. -
Citations
Citations to this article as recorded by
- Circulating cell-free DNA as a diagnostic and prognostic marker for cervical cancer
Preetiparna Parida, Gayathri Baburaj, Mahadev Rao, Shirley Lewis, Rama Rao Damerla
International Journal of Gynecological Cancer.2024; 34(2): 307. CrossRef - Prognostic value of circulating short-length DNA fragments in unresected glioblastoma patients
Arthur Daban, Ludivine Beaussire-Trouvay, Émilie Lévêque, Cristina Alexandru, Isabelle Tennevet, Olivier Langlois, Ovidiu Veresezan, Florent Marguet, Florian Clatot, Frédéric Di Fiore, Nasrin Sarafan-Vasseur, Maxime Fontanilles
Translational Oncology.2024; 42: 101897. CrossRef - Cervical Cancer Genetic Profile through Circulating Tumor DNA: What Can We Learn from Blood?
Sevastiani Antonouli, Valentina Di Nisio, Nikoletta Daponte, Athina-Ioanna Daponte, Alexandros Daponte
Biomolecules.2024; 14(7): 825. CrossRef - High throughput sequencing technology and its clinical application in circulating tumor DNA detection in patients with tumors.
Chonghe Xu, Dangui Zhou, Mei Zhu
Investigación Clínica.2024; 65(4): 476. CrossRef
- Circulating cell-free DNA as a diagnostic and prognostic marker for cervical cancer
- 4,499 View
- 183 Download
- 6 Web of Science
- 4 Crossref
- Lung Cancer
- Clinical Significance of Acute Kidney Injury in Lung Cancer Patients
- Semin Cho, Eunjeong Kang, Ji Eun Kim, U Kang, Hee Gyung Kang, Minsu Park, Kwangsoo Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Hyung-Jin Yoon, Hajeong Lee
- Cancer Res Treat. 2021;53(4):1015-1023. Published online January 18, 2021
- DOI: https://doi.org/10.4143/crt.2020.1010
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Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Acute kidney injury (AKI) in cancer patients is associated with increased morbidity and mortality. The incidence of AKI in lung cancer seems to be relatively higher compared with other solid organ malignancies, although its impact on patient outcomes remains unclear.
Materials and Methods
The patients newly diagnosed with lung cancer from 2004 to 2013 were enrolled in this retrospective cohort study. The patients were categorized according to the presence and severity of AKI. We compared all-cause mortality and long-term renal outcome according to AKI stage.
Results
A total of 3,202 patients were included in the final analysis. AKI occurred in 1,783 (55.7%) patients during the follow-up period, with the majority having mild AKI stage 1 (75.8%). During the follow-up of 2.6±2.2 years, total 1,251 patients (53.7%) were died and 5-year survival rate was 46.9%. We found that both AKI development and severity were independent risk factors for all-cause mortality in lung cancer patients, even after adjustment for lung cancer-specific variables including the stage or pathological type. In addition, patients suffered from more severe AKI tend to encounter de novo chronic kidney disease development, worsening kidney function, and end-stage kidney disease progression.
Conclusion
In this study, more than half of the lung cancer patients experienced AKI during their diagnosis and treatment period. Moreover, AKI occurrence and more advanced AKI were associated with a higher mortality risk and adverse kidney outcomes. -
Citations
Citations to this article as recorded by- Acute kidney injury associated with anti-PD-1 and anti-PD-L1 drugs: a meta-analysis of randomized clinical trials
Isabela Gonçalves Lima, Isabele Benck Usiro Cabral da Silva, Vitória Carpentieri Pípolo, Vinicius Daher Alvares Delfino, Paulo Roberto Bignardi
Immunopharmacology and Immunotoxicology.2024; 46(4): 470. CrossRef - Prevalence of kidney disease in patients with different types of cancer or hematological malignancies: a cross-sectional study
Feng Wu, Shiyuan Wang, Jialing Zhang, Peixin Wang, Aihua Zhang
International Urology and Nephrology.2024; 56(12): 3835. CrossRef - Protective effect of reduced glutathione on acute kidney injury in lung cancer patients treated with cisplatin: a retrospective cohort study
Ying Huang, Yang Li, Xialian Xu, Jie Teng, Xiaoqiang Ding, Jiarui Xu
Renal Failure.2024;[Epub] CrossRef - Association between renal dysfunction and outcomes of lung cancer: A systematic review and meta‑analysis
Huijuan Qian, Si Li, Ziyun Hu
Oncology Letters.2024;[Epub] CrossRef - Association and prediction of red blood cell distribution width to albumin ratio in all-cause mortality of acute kidney injury in critically ill patients
Chen Gao, Longkai Peng
Frontiers in Medicine.2023;[Epub] CrossRef - Point of care ultrasonography in onco-nephrology: A stride toward better physical examination
Bhavna Bhasin-Chhabra, Abhilash Koratala
World Journal of Nephrology.2023; 12(2): 29. CrossRef - Protocolo diagnóstico y tratamiento de la nefropatía en los pacientes con neoplasia sólida
Rodríguez Doyágüez, M.P. Morán Magro, C.M. Durán López, P. Martínez Miguel
Medicine - Programa de Formación Médica Continuada Acreditado.2023; 13(82): 4870. CrossRef
- Acute kidney injury associated with anti-PD-1 and anti-PD-L1 drugs: a meta-analysis of randomized clinical trials
- 7,293 View
- 193 Download
- 6 Web of Science
- 7 Crossref
- BCL2 Regulation according to Molecular Subtype of Breast Cancer by Analysis of The Cancer Genome Atlas Database
- Ki-Tae Hwang, Kwangsoo Kim, Ji Hyun Chang, Sohee Oh, Young A Kim, Jong Yoon Lee, Se Hee Jung, In Sil Choi
- Cancer Res Treat. 2018;50(3):658-669. Published online July 4, 2017
- DOI: https://doi.org/10.4143/crt.2017.134
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Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
We investigated B-cell lymphoma 2 (BCL2) regulation across DNA, RNA, protein, and methylation status according to molecular subtype of breast cancer using The Cancer Genome Atlas (TCGA) database.
Materials and Methods
We analyzed clinical and biological data on 1,096 breast cancers from the TCGA database. Biological data included reverse phase protein array (RPPA), mRNA sequencing (mRNA-seq), mRNA microarray, methylation, copy number alteration linear, copy number alteration nonlinear, and mutation data.
Results
The luminal A and luminal B subtypes showed upregulated expression of RPPA and mRNAseq and hypomethylation compared to the human epidermal growth factor receptor 2 (HER2) and triple-negative subtypes (all p < 0.001). No mutations were found in any subjects. High mRNA-seq and high RPPA were strongly associated with positive estrogen receptor, positive progesterone receptor (all p < 0.001), and negative HER2 (p < 0.001 and p=0.002, respectively). Correlation analysis revealed a strong positive correlation between protein and mRNA levels and a strong negative correlation between methylation and protein and mRNA levels (all p < 0.001). The high BCL2 group showed superior overall survival compared to the low BCL2 group (p=0.006).
Conclusion
The regulation of BCL2 was mainly associated with methylation across the molecular subtypes of breast cancer, and luminal A and luminal B subtypes showed upregulated expression of BCL2 protein, mRNA, and hypomethylation. Although copy number alteration may have played a minor role, mutation status was not related to BCL2 regulation. Upregulation of BCL2 was associated with superior prognosis than downregulation of BCL2. -
Citations
Citations to this article as recorded by- AL16ALA-SOD2 polymorphism predicts recurrence risk of breast cancer in patients treated with adjuvant tamoxifen
Maiquidieli Dal Berto, Laura Martin Manfroi, Aniúsca Vieira dos Santos, Giovana Tavares dos Santos, Gabriela Krüger da Costa, Camila Macedo Boaro, Péttala Rigon, Rafael José Vargas Alves, Claudia Giuliano Bica
Advances in Cancer Biology - Metastasis.2023; 8: 100108. CrossRef - Clinicopathological features and prognosis of patients with HER2-low breast cancer
Xin Yang, Yao Li, Xu lu, Xiaotian Ren, Bin Hua
BMC Cancer.2023;[Epub] CrossRef - Development of a prediction model for radiotherapy response among patients with head and neck squamous cell carcinoma based on the tumor immune microenvironment and hypoxia signature
Guang‐Li Zhu, Kai‐Bin Yang, Cheng Xu, Rui‐Jia Feng, Wen‐Fei Li, Jun Ma
Cancer Medicine.2022; 11(23): 4673. CrossRef - Significance of Bcl-2 expression in breast cancer
Nitika Kumari, Natarajan Suresh, Josephine A.
Biomedicine.2022; 42(4): 775. CrossRef - Detecting the expression of HRs and BCL2 via IHC can help identify luminal A-like subtypes of triple-positive breast cancers
Yingying Xu, Yonghao Liang, Guanghao Yin
Clinical and Translational Oncology.2022; 25(4): 1024. CrossRef - Early stability and late random tumor progression of a HER2-positive primary breast cancer patient-derived xenograft
Lorena Landuzzi, Arianna Palladini, Claudio Ceccarelli, Sofia Asioli, Giordano Nicoletti, Veronica Giusti, Francesca Ruzzi, Marianna L. Ianzano, Laura Scalambra, Roberta Laranga, Tania Balboni, Maddalena Arigoni, Martina Olivero, Raffaele A. Calogero, Car
Scientific Reports.2021;[Epub] CrossRef - Prognostic influences of BCL1 and BCL2 expression on disease-free survival in breast cancer
Ki-Tae Hwang, Young A. Kim, Jongjin Kim, Hyeon Jeong Oh, Jeong Hwan Park, In Sil Choi, Jin Hyun Park, Sohee Oh, Ajung Chu, Jong Yoon Lee, Kyu Ri Hwang
Scientific Reports.2021;[Epub] CrossRef - p53 and BLC2 Immunohistochemical Expression Across Molecular Subtypes in 1099 Early Breast Cancer Patients With Long-Term Follow-up: An Observational Study
Alessandra Fabi, Marcella Mottolese, Anna Di Benedetto, Francesca Sperati, Cristiana Ercolani, Simonetta Buglioni, Cecilia Nisticò, Gianluigi Ferretti, Patrizia Vici, Letizia Perracchio, Paola Malaguti, Michelangelo Russillo, Claudio Botti, Edoardo Pescar
Clinical Breast Cancer.2020; 20(6): e761. CrossRef - Methylation of the NT5E Gene Is Associated with Poor Prognostic Factors in Breast Cancer
Young Ju Jeong, Hoon Kyu Oh, Hye Ryeon Choi, Sung Hwan Park
Diagnostics.2020; 10(11): 939. CrossRef - Differential responses of epithelial cells from urinary and biliary tract to eggs of Schistosoma haematobium and S. mansoni
Rafael Nacif-Pimenta, Alessandra da Silva Orfanó, Ilana A. Mosley, Shannon E. Karinshak, Kenji Ishida, Victoria H. Mann, Paulo Marcos Zech Coelho, José M. Correia da Costa, Michael H. Hsieh, Paul J. Brindley, Gabriel Rinaldi
Scientific Reports.2019;[Epub] CrossRef - A CTC-Cluster-Specific Signature Derived from OMICS Analysis of Patient-Derived Xenograft Tumors Predicts Outcomes in Basal-Like Breast Cancer
Hariprasad Thangavel, Carmine De Angelis, Suhas Vasaikar, Raksha Bhat, Mohit Kumar Jolly, Chandandeep Nagi, Chad J. Creighton, Fengju Chen, Lacey E. Dobrolecki, Jason T. George, Tanya Kumar, Noor Mazin Abdulkareem, Sufeng Mao, Agostina Nardone, Mothaffar
Journal of Clinical Medicine.2019; 8(11): 1772. CrossRef -
BCL2L12: a multiply spliced gene with independent prognostic significance in breast cancer
Athina Kladi-Skandali, Diamantis C. Sideris, Andreas Scorilas
Clinical Chemistry and Laboratory Medicine (CCLM).2018; 57(2): 276. CrossRef
- AL16ALA-SOD2 polymorphism predicts recurrence risk of breast cancer in patients treated with adjuvant tamoxifen
- 15,764 View
- 330 Download
- 13 Web of Science
- 12 Crossref
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