Cancer Research and Treatment

Case Report

A Case of Pure Red Cell Aplasia Associated with Angioimmunoblastic T-cell Lymphoma: Jung-Hye Choi, Young-Ha Oh, Ile-Kyu Park; Cancer Res Treat. 2010;42(2):115-117. Published online June 30, 2010; DOI: https://doi.org/10.4143/crt.2010.42.2.115

Pure red cell aplasia is a bone marrow failure characterized by a progressive normocytic anemia and reticulocytopenia without leucopenia and thrombocytopenia. It is associated with various hematologic diseases. However, pure red cell aplasia with angioimmunoblastic T cell lymphoma has rarely been reported. Here we describe a 43-year-old woman with pure red cell aplasia associated with angioimmunoblastic T-cell lymphoma. She had severe anemia (hemoglobin 6.9 g/dL) and a low reticulocyte count (0.2%). Direct and indirect Coombs' tests were positive. A CT scan of the abdomen revealed marked hepatosplenomegaly and small multiple lymphadenopathies. A bone marrow biopsy revealed focal infiltration of abnormal lymphoid cells and absence of red cell precursors. Splenic biopsy was compatible with angioimmunoblastic T-cell lymphoma. Ultimately, diagnosis of pure red cell aplasia associated with angioimmunoblastic T-cell lymphoma was made. After initiating CHOP therapy, the patient achieved complete remission, which was accompanied, shortly thereafter, by a rise in hemoglobin levels which finally returned to normal.

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Sequential Complications of Hypercalcemia, Necrotizing Granulomatous Vasculitis, and Aplastic Anemia Occurring in One Patient with Angioimmunoblastic T-cell Lymphoma
Sriman Swarup, Jonathan Kopel, Kyaw Zin Thein, Kaiser Tarafdar, Khatrina Swarup, Seshadri Thirumala, Donald P. Quick
The American Journal of the Medical Sciences.2021; 361(3): 375. CrossRef
Angioimmunoblastic T-cell lymphoma accompanied by pure red cell aplasia: A case report
Teiko Kawahigashi, Izumi Kitagawa, Eri Tanaka
World Journal of Clinical Oncology.2020; 11(6): 405. CrossRef
EXPERIENCE OF MANAGING ANEMIA IN ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA
Hiromi Hashimoto, Shinya Ohata, Takako Tomita, Kazuko Konishi, Yoshinori Kubota, Maki Kanzawa, Yosuke Minami, Takeshi Sugimoto
Japanese Journal of Transfusion and Cell Therapy.2017; 63(1): 30. CrossRef
Angioimmunoblastic T-Cell Lymphoma Presenting with an Acute Serologic Epstein-Barr Virus Profile
Timothy Beer, Patrick Dorion
Hematology Reports.2015; 7(2): 5893. CrossRef
B-Cell Prolymphocytic Leukemia Carrying t(8;14)(q24;q32), Associated with Both Autoimmune Hemolytic Anemia and Pure Red Cell Aplasia
Futoshi Iioka, Takashi Akasaka, Masahiko Hayashida, Atsuko Okumura, Hitoshi Ohno
Journal of Clinical and Experimental Hematopathology.2014; 54(3): 219. CrossRef
Angioimmunoblastic T-cell lymphoma-associated pure red cell aplasia with abdominal pain
Jin Tao
World Journal of Clinical Oncology.2013; 4(3): 75. CrossRef
Pure Red Cell Aplasia and Lymphoproliferative Disorders: An Infrequent Association
Efthymia Vlachaki, Michael D. Diamantidis, Philippos Klonizakis, Styliani Haralambidou-Vranitsa, Elizabeth Ioannidou-Papagiannaki, Ioannis Klonizakis
The Scientific World Journal.2012; 2012: 1. CrossRef

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Original Articles

Clinical Value of New Staging Systems for Multiple Myeloma: Jung-Hye Choi, Jae-Hoon Yoon, Seong-Kyu Yang; Cancer Res Treat. 2007;39(4):171-174. Published online December 31, 2007; DOI: https://doi.org/10.4143/crt.2007.39.4.171

Abstract PDF PubReader ePub

Purpose

We wanted to investigate the validity of the recently introduced Southwest Oncology Group (SWOG) staging system and the International Staging System (ISS) by comparing both systems with the widely accepted Durie/Salmon (DS) system for multiple myeloma patients.

Materials and Methods

Between 1992 and 2005, 85 multiple myeloma patients (men: women 41:44, median age: 63 years (range: 36~87)) with available baseline values of albumin and β₂-microglobulin were enrolled. The clinical and laboratory data were retrospectively obtained.

Results

According to the ISS, 11 patients were stage I (12.9%), 30 patients stage II (35.3%) and 44 patients stage III (51.8%). The median survivals of the ISS stages I, II and III were 78.6 months, 31.8 months and 15.1 months, respectively (p=0.015). The DS staging system was not able to predict the survival. For the SWOG staging system, 14 patients were stage I (16.4%), 27 patients stage II (31.8%), 27 patients stage III (31.8%) and 17 patients were stage IV (20.0%). The median survivals of the SWOG staging system stage I, II, III and IV were 78.6 months, 31.8 months, 11.6 months and 24.8 months, respectively (p=0.0075).

Conclusion

The ISS staging system showed better reliability, simplicity and predictability for survival than the DS and SWOG staging systems for multiple myeloma patients.

Citations

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Risk stratification of cardiac metastases using late gadolinium enhancement cardiovascular magnetic resonance: prognostic impact of hypo-enhancement evidenced tumor avascularity
Angel T. Chan, William Dinsfriend, Jiwon Kim, Brian Yum, Razia Sultana, Christopher A. Klebanoff, Andrew Plodkowski, Rocio Perez Johnston, Michelle S. Ginsberg, Jennifer Liu, Raymond J. Kim, Richard Steingart, Jonathan W. Weinsaft
Journal of Cardiovascular Magnetic Resonance.2021; 23(1): 42. CrossRef
Clinical Utility of a Diagnostic Approach to Detect Genetic Abnormalities in Multiple Myeloma: A Single Institution Experience
Hyun Ae Jung, Mi-Ae Jang, Kihyun Kim, Sun-Hee Kim
Annals of Laboratory Medicine.2018; 38(3): 196. CrossRef
The Role of18F-FDG PET/CT in Multiple Myeloma Staging according to IMPeTUs: Comparison of the Durie–Salmon Plus and Other Staging Systems
Shengming Deng, Bin Zhang, Yeye Zhou, Xin Xu, Jihui Li, Shibiao Sang, Wei Zhang
Contrast Media & Molecular Imaging.2018; 2018: 1. CrossRef
Biochemical and electrophoretic evaluation of Clinically suspected multiple myeloma
R SREEVANI NAMANI, DR LAXMI NARAYANA SRIPURAM
International Journal of Pharma and Bio Sciences.2017;[Epub] CrossRef
Reconstruction of multiple myeloma lesions around the pelvis and acetabulum
Vasileios I. Sakellariou, Andreas F. Mavrogenis, Olga Savvidou, Franklin H. Sim, Panayiotis J. Papagelopoulos
European Journal of Orthopaedic Surgery & Traumatology.2015; 25(4): 643. CrossRef
Retrospective analysis of 264 multiple myeloma patients
CHUANYING GENG, NIAN LIU, GUANGZHONG YANG, AIJUN LIU, YUN LENG, HUIJUAN WANG, LIHONG LI, YIN WU, YANCHEN LI, WENMING CHEN
Oncology Letters.2013; 5(2): 707. CrossRef

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Phase II Study of Oxaliplatin, 5-fluorouracil, and Leucovorin in Relapsed or Metastatic Colorectal Cancer as Second Line Therapy: Duk-Joo Lee, Ho-Suk Oh, Jung-Hye Choi, Young-Yeul Lee, In-Soon Kim, Myung-Ju Ahn; Cancer Res Treat. 2006;38(4):201-205. Published online December 31, 2006; DOI: https://doi.org/10.4143/crt.2006.38.4.201

Abstract PDF PubReader ePub: Purpose
The purpose of the study was to assess the efficacy and safety of biweekly oxaliplatin in combination with leucovorin (LV)-modulated bolus plus infusion of 5-fluorouracil (5-FU) in patients with relapsed or metastatic colorectal cancer (CRC) as a second line therapy.
Materials and Methods
Between November 2002 and October 2005, 26 patients with histologically confirmed relapsed or metastatic CRC were enrolled. All patients were previously treated with irinotecan-based combination chemotherapy. The chemotherapy regimen consisted of oxaliplatin 85 mg/m² on day 1; LV 200 mg/m² on days 1 and 2; and 5-FU 400 mg/m² bolus IV with 600 mg/m² with a 22-hour infusion on days 1 and 2 every 2 weeks.
Results
The median age of the 26 patients was 50.5 years (range, 31~72). Their metastatic sites included: the liver (42.3%), peritoneum (26.9%), lung (23.1%) and ovary (7.7%). Twenty five patients were evaluated for their response. Four patients achieved partial responses and 15 patients had stable disease. The overall response rate was 16% (95% confidence interval; 1.7~30.3%). The median follow-up duration for the surviving patients was 7.4 months (range, 2.08~21.2). Median overall survival (OS) and 1-year OS rates were 16.7 months and 63.9%, respectively. The most common hematological toxicities were: NCI grade I/II leucopenia (49.3%), grade I/II neutropenia (41%) and grade I/II anemia (65.2%). The main non-hematological toxicities were: grade I/II peripheral neuropathy (16.1% and 21.5%, respectively) and nausea/vomiting (23.6%/18.5%). There was no life-threatening toxicity.
Conclusion
The oxaliplatin, 5-FU and LV combination chemotherapy, scheduled as a biweekly protocol, was effective and well tolerated in the treatment of relapsed or metastatic colorectal cancer patients as second line chemotherapy.

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Randomized, Multi-center Phase II Trial of Docetaxel Plus Cisplatin Versus Etoposide Plus Cisplatin as the First-line Therapy for Patients with Advanced Non-Small Cell Lung Cancer: Nam-Su Lee, Hee-Sook Park, Jong-Ho Won, Dae-Sik Hong, Su-Taek Uh, Sang-Jae Lee, Joo-Hang Kim, Se-Kyu Kim, Myung-Ju Ahn, Jung-Hye Choi, Suk-Chul Yang, Jung-Ae Lee, Keun-Seok Lee, Chang-Yeol Yim, Yong-Chul Lee, Chul-Soo Kim, Moon-Hee Lee, Kab-Do Jung, Hanlim Moon, Yl-Sub Lee; Cancer Res Treat. 2005;37(6):332-338. Published online December 31, 2005; DOI: https://doi.org/10.4143/crt.2005.37.6.332

Abstract PDF PubReader ePub

Purpose

We prospectively conducted a multi-center, open-label, randomized phase II trial to compare the efficacy and safety of docetaxel plus cisplatin (DC) and etoposide plus cisplatin (EC) for treating advanced stage non-small cell lung cancer (NSCLC).

Materials and Methods

Seventy-eight previously untreated patients with locally advanced, recurrent or metastatic NSCLC were enrolled in this study. The patients received cisplatin 75 mg/m² on day 1 and either docetaxel 75 mg/m² on day 1 or etoposide 100 mg/m² on days 1 to 3 in the DC or EC arm, respectively, every 3 weeks.

Results

The objective response rate was 39.4% (15/38) and 18.4% (7/38) (p=0.023) in the DC and EC arms, respectively. The median time to progression (TTP) was 5.9 and 2.7 months (p=0.119), and the overall survival was 12.1 and 8.7 months (p=0.168) in the DC and EC arms, respectively. The prognostic factors for longer survival were an earlier disease stage (stage III, p=0.0095), the responders to DC (p=0.0174) and the adenocarcinoma histology (p=0.0454). The grades 3 and 4 toxicities were similar in both arms, with more febrile neutropenia (7.9% vs. 0%) and fatigue (7.9% vs. 0%) being noted in the DC arm.

Conclusion

DC offered a superior overall response rate than does EC, along with tolerable toxicity profiles, although the DC drug combination did not show significantly improved survival and TTP.

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Correlations between objective response rate and survival-based endpoints in first-line advanced non-small cell lung Cancer: A systematic review and meta-analysis
Sarah Goring, Nebibe Varol, Nathalie Waser, Evan Popoff, Greta Lozano-Ortega, Adam Lee, Yong Yuan, Laura Eccles, Phuong Tran, John R. Penrod
Lung Cancer.2022; 170: 122. CrossRef

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Comparison of WHO and RECIST Criteria for Response in Metastatic Colorectal Carcinoma: Jung-Hye Choi, Myung-Ju Ahn, Hyan-Chul Rhim, Jin-Woo Kim, Gang-Hong Lee, Young-Yeul Lee, In-Soon Kim; Cancer Res Treat. 2005;37(5):290-293. Published online October 31, 2005; DOI: https://doi.org/10.4143/crt.2005.37.5.290

Abstract PDF PubReader ePub

Purpose

This study compared the WHO criteria with the response evaluation criteria in solid tumors (RECIST) in the same patients with metastatic colorectal cancer in order to determine the significance of the RECIST. In addition, this study compared the estimations of medical oncologists with those of a radiologist.

Materials and Methods

Between 2002 and 2005, a total of 48 patients (male: female ratio, 29:19; median age, 58 years) with measurable lesions receiving chemotherapy for metastatic colorectal carcinoma were enrolled in this study. Two medical oncologists and one radiologist, who were blinded to the patients' condition, independently reviewed all the CT images. The results were compared using a kappa test.

Results

The kappa test for concordance between the WHO and RECIST criteria of the medical oncologists and the radiologist were 0.908 and 0.841, respectively. The level of concordance between the investigators using the WHO and RECIST were 0.722 and 0.753, respectively.

Conclusion

The RECIST criteria are comparable to the WHO criteria in evaluating the response of colorectal carcinoma, but have simple and reproducible guidelines. The use of RECIST is recommended for evaluating the treatment efficacy in clinical trials and practice.

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Menghan Zhang, Qi Wang, Gongming Zhang, Guangming Li, Ronghua Jin, Huichun Xing
Frontiers in Pharmacology.2024;[Epub] CrossRef
Feasibility of an artificial intelligence system for tumor response evaluation
Nie Xiuli, Chen Hua, Gao Peng, Yu Hairong, Sun Meili, Yan Peng
BMC Medical Imaging.2024;[Epub] CrossRef
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Correlation Between Early Time-to-Event Outcomes and Overall Survival in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Receiving Definitive Chemoradiation Therapy: Systematic Review and Meta-Analysis
Christopher M. Black, Sam Keeping, Ali Mojebi, Karthik Ramakrishnan, Diana Chirovsky, Navneet Upadhyay, Dylan Maciel, Dieter Ayers
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Ran Harel, Tehila Kaisman-Elbaz, Todd Emch, Paul Elson, Samuel T Chao, John H Suh, Lilyana Angelov
Neurosurgical Focus.2022; 53(5): E10. CrossRef
Lung-RADS Version 1.1: Challenges and a Look Ahead, From the AJR Special Series on Radiology Reporting and Data Systems
Lydia Chelala, Rydhwana Hossain, Ella A. Kazerooni, Jared D. Christensen, Debra S. Dyer, Charles S. White
American Journal of Roentgenology.2021; 216(6): 1411. CrossRef
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Aimée Obolari Durço, Lino Sérgio Rocha Conceição, Diego Santos de Souza, Carlos Anselmo Lima, Jullyana de Souza Siqueira Quintans, Márcio Roberto Viana dos Santos
Phytomedicine Plus.2021; 1(3): 100090. CrossRef
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Shah Naveed, Hasina Qari, Cao M Thau, Pipit Burasakarn, Abdul W Mir
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Thomas Beyer, Luc Bidaut, John Dickson, Marc Kachelriess, Fabian Kiessling, Rainer Leitgeb, Jingfei Ma, Lalith Kumar Shiyam Sundar, Benjamin Theek, Osama Mawlawi
Cancer Imaging.2020;[Epub] CrossRef
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Chun Sing Lam, Lok Pui Cheng, Li Min Zhou, Yin Ting Cheung, Zhong Zuo
Chinese Medicine.2020;[Epub] CrossRef
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Sirisha L. Mushti, Flora Mulkey, Shenghui Tang, Harpreet Singh, Steven J. Lemery, Kirsten B. Goldberg, Rajeshwari Sridhara, Patricia Keegan, Paul G. Kluetz, Richard Pazdur, Marc R. Theoret, Julia A. Beaver
Current Oncology Reports.2020;[Epub] CrossRef
Salvage systemic therapy for advanced gastric and oesophago-gastric junction adenocarcinoma
Yoko Tomita, Max Moldovan, Rachael Chang Lee, Amy HC Hsieh, Amanda Townsend, Timothy Price
Cochrane Database of Systematic Reviews.2020;[Epub] CrossRef
The role of neoadjuvant chemotherapy or chemoradiotherapy for advanced gallbladder cancer – A systematic review
Abdul R Hakeem, Michail Papoulas, Krishna V Menon
European Journal of Surgical Oncology.2019; 45(2): 83. CrossRef
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Inthuorn Kulma, Kanyarat Boonprasert, Kesara Na-Bangchang
Cancer Chemotherapy and Pharmacology.2019; 84(5): 959. CrossRef
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Zuhuan Gan, Qiyuan Zou, Yan Lin, Zihai Xu, Zhong Huang, Zhichao Chen, Yufeng Lv
Oncology Letters.2019;[Epub] CrossRef
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Mizuki Nishino
American Society of Clinical Oncology Educational Book.2018; (38): 1019. CrossRef
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Ralf Gutzmer, Kevin J. Harrington, Christoph Hoeller, Celeste Lebbé, Josep Malvehy, Katarina Öhrling, Gerald Downey, Reinhard Dummer
European Journal of Dermatology.2018; 28(6): 736. CrossRef
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Chuanben Chen, Xiurong Lin, Yuanji Xu, Penggang Bai, Youping Xiao, Yuhui Pan, Chao Li, Zhizhong Lin, Mingwei Zhang, Yunbin Chen
Oncotarget.2017; 8(29): 46937. CrossRef
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Surgery Today.2016; 46(2): 139. CrossRef
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Mustafa Aras, Tanju Y. Erdil, Faysal Dane, Serkan Gungor, Tunc Ones, Fuat Dede, Sabahat Inanir, Halil T. Turoglu
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Sandip Basu, Rakesh Kumar, Rohit Ranade
PET Clinics.2015; 10(1): 9. CrossRef
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Hyeong Su Kim, Ji Won Kim, Jung Han Kim, Dae Ro Choi, A. Rum Han, Min-Joeng Kim, Byung Chun Kim, Dae Young Zang
Oncology.2015; 88(2): 69. CrossRef
Tumor response assessment by measuring the single largest lesion per organ in patients with advanced non-small cell lung cancer
Hyeong Su Kim, Jung Han Kim, Ik Yang
Lung Cancer.2014; 85(3): 385. CrossRef
Nucleotide excision repair gene polymorphisms and prognosis of non-small cell lung cancer patients receiving platinum-based chemotherapy: A meta-analysis based on 44 studies
DONGNING HUANG, YANG ZHOU
Biomedical Reports.2014; 2(4): 452. CrossRef
XRCC1 and GSTP1 polymorphisms and prognosis of oxaliplatin-based chemotherapy in colorectal cancer: a meta-analysis
Fanghui Ye, Zhenfang Liu, Aihua Tan, Ming Liao, Zengnan Mo, Xiaobo Yang
Cancer Chemotherapy and Pharmacology.2013; 71(3): 733. CrossRef
Relationship between 6‐ and 9‐month progression‐free survival and overall survival in patients with metastatic urothelial cancer treated with first‐line cisplatin‐based chemotherapy
Matthew D. Galsky, Susan Krege, Chia‐Chi Lin, Noah Hahn, Thorsten Ecke, Erin Moshier, Guru Sonpavde, James Godbold, William K. Oh, Aristotle Bamias
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Mack Roach, Jean‐Louis Alberini, Alain Paul Pecking, Alessandro Testori, Francesco Verrecchia, Javier Soteldo, Ute Ganswindt, John L. Joyal, John W. Babich, Russell S. Witte, Evan Unger, Ronald Gottlieb
Journal of Surgical Oncology.2011; 103(6): 587. CrossRef

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114 Download
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Thymidylate Synthase, Thymidine Phosphorylase, VEGF and p53 Protein Expression in Primary Colorectal Cancer for Predicting Response to 5-fluorouracil-based Chemotherapy: Myung-Ju Ahn, Jung-Hye Choi, Ho-Suk Oh, Young-Yeul Lee, In-Soon Kim, Il-Young Choi, Kang-Hong Lee, Kang-Won Song, Chan-Kum Park; Cancer Res Treat. 2005;37(4):216-222. Published online August 31, 2005; DOI: https://doi.org/10.4143/crt.2005.37.4.216

Abstract PDF PubReader ePub

Purpose

In the treatment of advanced metastatic colorectal cancer, several new agents, such as irinotecan and oxaliplatin, have been developed, which have improved both disease free and overall survivals. Among these agents, 5-fluorouracil (5-FU) still remains one of the most active agents, and the selection of patients who can benefit from 5-FU-based chemotherapy is still important, as those unlikely to benefit could be spared the harmful side effects. The expression levels of thymidylate synthase (TS), thymidine phosphorylase (TP) and p53 have been known to be associated with the clinical response to 5-FU-based therapy as well as the prognosis, and that of vascular endothelial growth factor (VEGF) is associated with poor survival.

Materials and Methods

The relationship between the expressions of TS, TP, VEGF and p53 in primary tumors, using immunohistochemistry, and the response of 45 metastatic colorectal cancer patients (M:F=25:20, median age 59 yrs) to 5-FU-based chemotherapy were evaluated.

Results

Thirty-seven patients were treated with 5-FU/LV/irinotecan (FOLFIRI) and 8 with 5-FU/LV/oxaplatin (FOLFOX). The overall response rate was 28.9% (13/45). When immunohistochemically analyzed with monoclonal antibodies against TS, TP, VEGF and p53, 55.6% of the patients (25/45) were positive for TS, 48.9% (22/45) for TP, 82.2% (37/45) for VEGF, and 80% (36/45) for p53. There was a significant difference in the intensity of TS expression between the clinical responders and non-responders (p=0.036). In terms of the staining pattern of TS expression, diffuse staining was correlated with a poor response (p=0.012) and poor survival (p=0.045). However, there was no correlation between the expressions of TP, VEGF or P53 and the response to chemotherapy.

Conclusion

These results suggest that the expression of TS in primary colorectal cancer might be an important prognostic factor for chemotherapy response and survival, and might be a useful therapeutic marker for the response of chemotherapy.

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Laura Grumetti, Rita Lombardi, Federica Iannelli, Biagio Pucci, Antonio Avallone, Elena Di Gennaro, Alfredo Budillon
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Wilson Roberto Batista, Gianni Santos, Flávia Maria Ribeiro Vital, Delcio Matos
Sao Paulo Medical Journal.2019; 137(1): 33. CrossRef
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cDNA Microarray Analysis of Differential Gene Expression in Gastric Cancer Cells Sensitive and Resistant to 5-Fluorouracil and Cisplatin: Myung-Ju Ahn, Young-Do Yoo, Ki-Hwan Lee, Joon-Ik Ahn, Dong-Hyun Yu, Hye-Sook Lee, Ho-Suck Oh, Jung-Hye Choi, Yong-Sung Lee; Cancer Res Treat. 2005;37(1):54-62. Published online February 28, 2005; DOI: https://doi.org/10.4143/crt.2005.37.1.54

Abstract PDF PubReader ePub

Purpose

Gastric cancer is one of the most prevalent cancers worldwide. 5-fluorouracil (5-FU) and cisplatin are the most commonly used drugs for the treatment of gastric cancer. However, a significant number of tumors often fail to respond to chemotherapy.

Materials and Methods

To better understand the molecular mechanisms underlying drug resistance in gastric cancer the gene expression in gastric cancer cells, which were either sensitive or resistant to 5-FU and cisplatin, were examined using cDNA microarray analysis. To confirm the differential gene expression, as determined using the microarray, semiquantitative RT-PCR was performed on a subset of differentially expressed cDNAs.

Results

69 and 45 genes, which were either up-regulated (9 and 22 genes) or down-regulated (60 and 25 genes), were identified in 5-FU- and cisplatin-resistant cells, respectively. Several genes, such as adaptor-related protein complex 1 and baculoviral IAP repeat-containing 3, were up-regulated in both drug-resistant cell types. Several genes, such as the ras homolog gene family, tropomyosin, tumor rejection antigen, protein disulfide isomerase-related protein, melanocortin 1 receptor, defensin, cyclophilin B, dual specificity phosphatase 8 and hepatocyte nuclear factor 3, were down-regulated in both drugresistant cell types.

Conclusion

These findings show that cDNA microarray analysis can be used to obtain gene expression profiles that reflect the effect of anticancer drugs on gastric cancer cells. Such data may lead to the assigning of signature expression profiles of drug-resistant tumors, which may help predict responses to drugs and assist in the design of tailored therapeutic regimens to overcome drug resistance.

Citations

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Molecular classification and prediction in gastric cancer
Xiandong Lin, Yongzhong Zhao, Won-min Song, Bin Zhang
Computational and Structural Biotechnology Journal.2015; 13: 448. CrossRef
Identification of Differentially-Expressed Genes in Intestinal Gastric Cancer by Microarray Analysis
Shizhu Zang, Ruifang Guo, Rui Xing, Liang Zhang, Wenmei Li, Min Zhao, Jingyuan Fang, Fulian Hu, Bin Kang, Yonghong Ren, Yonglong Zhuang, Siqi Liu, Rong Wang, Xianghong Li, Yingyan Yu, Jing Cheng, Youyong Lu
Genomics, Proteomics & Bioinformatics.2014; 12(6): 276. CrossRef
Protein disulfide isomerase in redox cell signaling and homeostasis
Francisco R.M. Laurindo, Luciana A. Pescatore, Denise de Castro Fernandes
Free Radical Biology and Medicine.2012; 52(9): 1954. CrossRef

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Phase II Study of Irinotecan, 5-Fluorouracil, and Leucovorin in Relapsed or Metastatic Colorectal Cancer as First-line Therapy: Young-Woong Won, Young-Hyo Lim, Ho-Yong Park, Ho-Suk Oh, Jung-Hye Choi, Young-Yeul Lee, In-Soon Kim, Il-Young Choi, Myung-Ju Ahn; Cancer Res Treat. 2004;36(4):235-239. Published online August 31, 2004; DOI: https://doi.org/10.4143/crt.2004.36.4.235

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Background

The purpose of this study was to assess the efficacy and toxicity of biweekly irinotecan plus 5-fluorouracil (FU) and leucovorin (LV) in patients with relapsed or metastatic colorectal cancer.

Materials and Methods

Between March 2002 and May 2004, 24 patients with histologically confirmed relapsed or metastatic colorectal cancer were enrolled in this study. One chemotherapy cycle consisted of irinotecan 180 mg/m² on days 1 and 15; 5-FU 400 mg/m² bolus IV with 600 mg/m² by a 22 hour intravenous infusion on days 1, 2, 15 and 16; and leucovorin 20 mg/m² on days 1, 2, 15 and 16, every 4 weeks.

Results

The median age of the 24 was 57.5 years (range, 38~69). Their metastatic sites included: the liver (62.5%), lung (20.8%), peritoneum (16.7%), lymph node (12.5%), ovary (8.3%) and pelvis/vagina (8.3%). Twenty-two patients were evaluable for a response. Six and 7 patients achieved partial responses and stable diseases, respectively. The overall response rate was 27.3% (95% Confidence interval; 10.3~44.5%). The median follow-up duration for surviving patients was 14.7 months (range, 1.7~26.5). Median overall survival (OS) and 1-year OS rates were 19 months and 86.3%, respectively. Median response duration and median progression free survival were 7.47 and 5.57 months, respectively. A total of 83 cycles (median 4 cycles) were administered. The main non-hematologic toxicities were nausea/vomiting (44.5%/18.1%) and diarrhea (8.4%). The most common hematologic toxicity was NCI grade I/II anemia (31.3%) and grade I/II neutropenia was 10.8%. There was no life-threatening toxicity.

Conclusion

The results suggested that irinotecan, 5-FU and leucovorin combination chemotherapy in a biweekly schedule is a practical and tolerable treatment option in patients with advanced colorectal cancer.

Citations

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A Phase I Study of UGT1A1 *28/*6 Genotype-Directed Dosing of Irinotecan (CPT-11) in Korean Patients with Metastatic Colorectal Cancer Receiving FOLFIRI
Kyu-Pyo Kim, Yong Sang Hong, Jae-Lyun Lee, Kyun Seop Bae, Ho-Sook Kim, Jae-Gook Shin, Jung Shin Lee, Tae Won Kim
Oncology.2015; 88(3): 164. CrossRef
Effect of an Irinotencan, 5-Fluorouracil, and Leucovorin Combination Chemotherapy (FOLFIRI) in Metastatic Colorectal Cancer
Seung Hyun Lee, Byung Kwon Ahn, Sung Uhn Baek
Journal of the Korean Society of Coloproctology.2007; 23(5): 333. CrossRef
A Phase II Study of Irinotecan, 5-Fluorouracil and Leucovorin for Treatment in Patients with Previously Untreated Advanced Colorectal Cancer
Sang-Byung Bae, Nam-Su Lee, Han-Jo Kim, Kyoung-Ha Kim, Hyun-Jung Kim, Chan-Kyu Kim, Kyu-Taeg Lee, Sung-Kyu Park, Jong-Ho Won, Dae-Sik Hong, Hee-Sook Park
Cancer Research and Treatment.2006; 38(2): 72. CrossRef
Irinotecan, Continuous 5-Fluorouracil, and Low dose of Leucovorin (modified FOLFIRI) as First Line of Therapy in Recurrent or Metastatic Colorectal Cancer
Myung-Ah Lee, Jae-Ho Byun, Byoung-Young Shim, In-Sook Woo, Jin-Hyung Kang, Young Seon Hong, Kyung Shik Lee, Myung Gyu Choi, Suk Kyun Chang, Seong Taek Oh, Sung Il Choi, Doo Suk Lee
The Korean Journal of Internal Medicine.2005; 20(3): 205. CrossRef
Responsiveness of CPT-11 in Respect to hMLH1 and hMSH2 Protein Expression in the Primary Colorectal Cancer
In Ja Park, Hee Cheol Kim, Chang Sik Yu, Heung Moon Chang, Jea Hwan Lee, Jong Hoon Kim, Tae Won Kim, Jung Sun Kim, Jin Cheon Kim
Cancer Research and Treatment.2004; 36(6): 360. CrossRef

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Combination Chemotherapy of Heptaplatin, Paclitaxel and 5-Fluorouracil in Patients with Advanced Gastric Cancer: a Pilot Study: Myung-Ju Ahn, Ho-Suck Oh, Jung-Hye Choi, Young-Yeul Lee, In-Soon Kim, Il-Young Choi, Oh Young Lee, Ho-Soon Choi, Sung-Joon Kwon; Cancer Res Treat. 2004;36(3):182-186. Published online June 30, 2004; DOI: https://doi.org/10.4143/crt.2004.36.3.182

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Purpose

To evaluate the efficacy and toxicity of heptaplatin, paclitaxel, and 5-fluorouracil combination chemotherapy in patients with advanced gastric cancer.

Materials and Methods

Between July 2002 and September 2003, nineteen patients were enrolled in this study. Paclitaxel 135 mg/m² iv on day 1, heptaplatin 400 mg/m² iv on day 2 and 5-fluorouracil 800 mg/m² on day 2~4 were administered and the regimen was repeated every 3 weeks.

Results

The median age of the patients was 60 years (range: 32~74) and the most common sites of metastasis were liver and lymph nodes. In the 16 evaluated patients, the overall response rate was 43.8%, but this was without any complete response. The median time to disease progression was 3.93 months (range: 0.26~8.1) and the median response duration for the 7 responding patients was 3.83 months (range: 1.48~6.07). The median overall survival for 19 patients was 7.01 months (range: 0.26~17.44). A median of 3 cycles (range: 1~7) and a total of 65 cycles were administered and evaluated for toxicity. The most common hematologic toxicities were NCI grade I/II anemia (47.7%), neutropenia (9.2%) and thrombocytopenia (6.2%). The most common non-hematologic toxicities more than grade II were nausea/vomiting (30.8%/9.2%). One elderly patient with ECOG 2 had a life-threatening complication of pneumonia.

Conclusion

The combination of heptaplatin, paclitaxel, and 5-fluorouracil showed significant activity and favorable toxicity profiles in patients with advanced gastric cancer. However, one elderly patient who had poor performance experienced a life-threatening toxicity/complication. Our results suggest that the efficacy of this combination chemotherapy can be maximized when administered to the patients with good performance status. Further studies with large numbers of patients and long-term follow-up study will be needed.

Citations

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Application of Approved Cisplatin Derivatives in Combination Therapy against Different Cancer Diseases
Dobrina Tsvetkova, Stefka Ivanova
Molecules.2022; 27(8): 2466. CrossRef
Synthesis of novel heptaplatin derivatives and evaluation of their ability to inhibit proliferation of cancer cell lines
W. Xu, D. C. Wang
Russian Journal of General Chemistry.2016; 86(4): 939. CrossRef

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Radiofrequency Ablation for Metastatic Hepatic Tumor in Colorectal Carcinoma: Jung-Hye Choi, Myung-Ju Ahn, Hyunchul Rhim, Heung Woo Lee, Ho-Suk Oh, Young-Yeul Lee, Il-Young Choi, In-Soon Kim; Cancer Res Treat. 2004;36(2):128-131. Published online April 30, 2004; DOI: https://doi.org/10.4143/crt.2004.36.2.128

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Purpose

The purpose of this study was to assess the efficacy and safety of radiofrequency ablation (RFA) to treat hepatic metastasis in patients with colorectal carcinoma.

Materials and Methods

Between May 1999 and July 2002, a total of 45 tumors in 24 patients with colorectal cancer were treated with RFA. Thirteen patients received systemic chemotherapy after the RFA procedure. The ablation was performed percutaneously under ultrasound guidance using cool-tip or expandable electrodes and an RF generator. The medical records as well as the CT scan results taken every 3 months were retrospectively reviewed.

Results

The median follow-up duration of the surviving patients was 11.7 months (4.6~32.2 months). Complete tumor necrosis was achieved in 17 patients (70.8%) on an immediate (<24 hrs) CT scan. The median survival was 17.1 months. The 1- and 2-year survival rates were 80.5 and 25.8%, respectively. In a univariate analysis, complete necrosis, tumor size and post-RFA chemotherapy were significant factors for survival. Nineteen of the 24 patients developed a recurrence or progressed (79.2%). The median progression free survival was 5.5 months. There were no treatment related deaths or serious adverse effects, with the exception of one case of respiratory failure.

Conclusion

These results suggest that RFA is a well-tolerated and effective method to treat hepatic metastasis in colorectal carcinomas.

Citations

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Single-centre survival analysis over 10 years after MR-guided radiofrequency ablation of liver metastases from different tumour entities
Susann-Cathrin Olthof, Daniel Wessling, Moritz T. Winkelmann, Hansjörg Rempp, Konstantin Nikolaou, Rüdiger Hoffmann, Stephan Clasen
Insights into Imaging.2022;[Epub] CrossRef
Prognostic factors after ultrasound‐guided percutaneous ablation of colorectal liver metastases: A systematic review
Jeanett Klubien, Andreas P. Kohl, Christian P. Nolsøe, Jacob Rosenberg, Hans‐Christian Pommergaard
Australasian Journal of Ultrasound in Medicine.2018; 21(2): 87. CrossRef
Impact of timing and cycles of systemic chemotherapy on survival outcome of colorectal liver metastases patients treated by percutaneous microwave ablation
Kai Zhang, Jie Yu, Fubo Zhou, Xiaoling Yu, Xin Li, Jianbin Wang, Zhiyu Han, Zhigang Cheng, Ping Liang
International Journal of Hyperthermia.2016; 32(5): 531. CrossRef
Efficacy and safety of thermal ablation in patients with liver metastases
Yingjun Liu, Shengping Li, Xiangbin Wan, Yi Li, Binkui Li, Yaqi Zhang, Yunfei Yuan, Yun Zheng
European Journal of Gastroenterology & Hepatology.2013; 25(4): 442. CrossRef
CT- versus coregistered FDG-PET/CT-based radiation therapy plans for conformal radiotherapy in colorectal liver metastases: a dosimetric comparison
Cem Parlak, Erkan Topkan, Serhat Sonmez, Cem Onal, Mehmet Reyhan
Japanese Journal of Radiology.2012; 30(8): 628. CrossRef

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The Differential Gene Expression Profiles between Sensitive and Resistant Breast Cancer Cells to Adriamycin by cDNA Microarray: Myung-Ju Ahn, Ki-Hwan Lee, Joon-Ik Ahn, Dong-Hyun Yu, Hye-Sook Lee, Jung-Hye Choi, Joung Soon Jang, Jong Min Bae, Yong-Sung Lee; Cancer Res Treat. 2004;36(1):43-49. Published online February 29, 2004; DOI: https://doi.org/10.4143/crt.2004.36.1.43

Abstract PDF PubReader ePub

Purpose

Adriamycin® is one of the most commonly used drugs in the treatment of breast cancer. This study was performed to understand the molecular mechanisms of drug resistance in breast cancer cells.

Materials and Methods

We have analyzed the MCF-7 breast cell line and its adriamycin-resistant variants, MCF-7/ADR using human 10 K element cDNA microarrays.

Results

We defined 68 genes that were up-regulated (14 genes) or down-regulated (54 genes) in adriamycin resistant breast cancer cells. Several genes, such as G protein-coupled receptor kinase 5, phospholipase A2, guanylate cyclase 1, vimentin, matrix metalloproteinase 1 are up-regulated in drug resistant cells. Several genes, such as interferon, alpha-inducible protein 27, forkhead box M1, mitogen-activated protein kinase 6, regulator of mitotic spindle assembly 1 and tumor necrosis factor superfamily are down-regulated in adriamycin resistant cells. The altered expression of genes observed in microarray was verified by RT-PCR.

Conclusion

These findings show that cDNA microarray analysis can be used to obtain gene expression profiles reflecting the effect of anticancer drugs on breast cancer cells. Such data may lead to the assigning of signature expression profiles of drug-resistant tumors which may help predict responses to drugs and assist in the design of tailored therapeutic regimens to overcome drug resistance.

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Rafia Zafar, Syeda Aqsa Batool Bukhari, Habib Nasir
ACS Omega.2024; 9(24): 25694. CrossRef
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Zahra Shamsadin-Azad, Mohammad Ali Taher, Hadi Beitollahi
Journal of the Iranian Chemical Society.2024; 21(10): 2623. CrossRef
GRK5 Deficiency Causes Mild Cognitive Impairment due to Alzheimer’s Disease
William Z. Suo, Bruce Citron
Journal of Alzheimer's Disease.2022; 85(4): 1399. CrossRef
pH-Sensitive chitosan-tripolyphosphate nanoparticles increase doxorubicin-induced growth inhibition of cervical HeLa tumor cells by apoptosis and cell cycle modulation
Daniele R. Nogueira-Librelotto, Laís E. Scheeren, Letícia B. Macedo, M. Pilar Vinardell, Clarice M.B. Rolim
Colloids and Surfaces B: Biointerfaces.2020; 190: 110897. CrossRef
Voltammetric detection of anticancer drug Doxorubicin at pencil graphite electrode: A voltammetric study
S. Deepa, B.E. Kumara Swamy, K. Vasantakumar Pai
Sensors International.2020; 1: 100033. CrossRef
A surfactant SDS modified carbon paste electrode as an enhanced and effective electrochemical sensor for the determination of doxorubicin and dacarbazine its applications: A voltammetric study
S. Deepa, B.E. Kumara Swamy, K. Vasantakumar Pai
Journal of Electroanalytical Chemistry.2020; 879: 114748. CrossRef
Doxorubicin induces an extensive transcriptional and metabolic rewiring in yeast cells
Hilal Taymaz-Nikerel, Muhammed Erkan Karabekmez, Serpil Eraslan, Betül Kırdar
Scientific Reports.2018;[Epub] CrossRef
Accelerating Alzheimer’s pathogenesis by GRK5 deficiency via cholinergic dysfunction
William Z. Suo
Advances in Alzheimer's Disease.2013; 02(04): 148. CrossRef
Discovery of IL-18 As a Novel Secreted Protein Contributing to Doxorubicin Resistance by Comparative Secretome Analysis of MCF-7 and MCF-7/Dox
Ling Yao, Yan Zhang, Keying Chen, Xiaofang Hu, Lisa X. Xu, Irina V. Lebedeva
PLoS ONE.2011; 6(9): e24684. CrossRef
cDNA Microarray Analysis of Differential Gene Expression in Gastric Cancer Cells Sensitive and Resistant to 5-Fluorouracil and Cisplatin
Myung-Ju Ahn, Young-Do Yoo, Ki-Hwan Lee, Joon-Ik Ahn, Dong-Hyun Yu, Hye-Sook Lee, Ho-Suck Oh, Jung-Hye Choi, Yong-Sung Lee
Cancer Research and Treatment.2005; 37(1): 54. CrossRef

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