PURPOSE The objective of this study was to assess the effect of postoperative radiotherapy on the outcome of esophageal cancer with microscopically positive resection margin by comparing the results with those of patients with negative resection margin. MATERIALS AND METHODS Medical records of 88 patients treated with macroscopic resection followed by postoperative radiotherapy for stage II or III squamous cell carcinoma of the esophagus from June 1984 to March 2008 were reviewed.
Twelve patients had received chemotherapy. Patients were classified into two groups based on resection margin status: negative resection margin (group A, n=66) and microscopically positive resection margin (group B, n=22).
Median follow-up duration of living patients was 68 months (range, 18 to 115 months). Median total radiation dose of group A and group B was 51.5 Gy (range, 45 to 69 Gy) and 52.1 Gy (range, 45 to 64 Gy), respectively. RESULTS Median overall survival and disease-free survival were 15 and 10 months, respectively. The five-year overall survival, disease-free survival, and local control rates for group A and group B were 15.9% and 16.4%, 13.5% and 9.1%, and 76.3% and 69.6%, respectively. No statistically significant difference in terms of overall survival, disease-free survival, and local control (p=0.295, p=0.209, and p=0.731, respectively) was observed between group A and group B. Seven patients experienced toxicity of grade 3 or higher. CONCLUSION A significant portion of patients with margin involvement reached long term survival after addition of postoperative radiotherapy. These results suggest a potential role of postoperative radiotherapy, especially for patients with margin involvement.
The Impact of Adjuvant Postoperative Radiation Therapy and Chemotherapy on Survival After Esophagectomy for Esophageal Carcinoma Andrew T. Wong, Meng Shao, Justin Rineer, Anna Lee, David Schwartz, David Schreiber Annals of Surgery.2017; 265(6): 1146. CrossRef
Alpha linolenic acid and oleic acid additively down-regulate malignant potential and positively cross-regulate AMPK/S6 axis in OE19 and OE33 esophageal cancer cells Hyun-Seuk Moon, Saime Batirel, Christos S. Mantzoros Metabolism.2014; 63(11): 1447. CrossRef
Jae Gahb Park, Nam Sook Kwon, Jin Pok Kim, Seung Keun Oh, Kuhn Uk Lee, Kuk Jin Choe, Soo Tae Kim, Yung Jue Bang, Noe Kyeong Kim, Soon Beom Kang, Myon Woo Shin, Sang Hoon Lee, Joo Hyun Kim, Chong Wook
Serum-free, defined medium ACL-4 has proven to be useful for the establishment and maintenance of human colorectal carcinoma and lung adenocarcinoma cell lines. To determine the general usefulness of ACL-4 as a medium for establishing cell lines, we compared the growth of cells from many different tumor specimens in R10, ACL-4 and AR5 (ACL-4 plus 5% FBS). From June 1987 to July 1988, 69 specimens from a wide variety of human tumors were cultured in R10 and ACL-4 or AR5. Eleven cancer cell lines were established ...... seven cell lines (4 stomach carcinoma, 1 rectal carcinoma, 1 ovarian carcinoma, 1 osteosarcoma) in R10; two cell lines (1 uterine cervical cancer, 1 laryngeal carcinoma) in ACL-4; and two cell lines in AR5 (1 colon carcinoma, 1 rectal carcinoma) (Table I & 2). Of interest, two B lymphoblastoid (non-neoplastic) cell iines were established from a stomach cancer and an acute myeloblastic leukemia specimen grown in ACL-4. We have found that sodium pyruvate, transferrin, and insulin were very important for the growth of uterine cervical cancer cells. Early in this study, we also found that fibroblast growth was effectively suppressed by culturing tumor cells in the serum free medium ACL-4. Therefore, in later attempts, when possible loss of cultures by fibroblast overgrowth was observed, serum containing media were replaced by ACL-4 to suppress and eventually eliniinate the fibroblast contamination. Although we were able tu establish only 11 new cancer cell lines from 69 specimens, our study has extended the use of ACL-4 medium with or without serum for the growth of uterine cervical and laryngeal cancer cells.