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Central nervous system
A Nationwide, Population-Based Epidemiology Study of Primary Central Nervous System Tumors in Korea, 2007-2016: A Comparison with United States Data
Ho Kang, Sang Woo Song, Johyun Ha, Young-Joo Won, Chul-Kee Park, Heon Yoo, Kyu-Won Jung
Cancer Res Treat. 2021;53(2):355-366.   Published online October 7, 2020
DOI: https://doi.org/10.4143/crt.2020.847
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The purpose of this study was to determine the epidemiologic characteristics and survival of patients with primary brain and other central nervous system (CNS) tumors in Korea and to compare our findings with those from the United States.
Materials and Methods
We collected data on primary brain and CNS tumors diagnosed between 2007 and 2016 from the Korea Central Cancer Registry. The age-standardized incidence rates (ASRs) and 5-year relative survival rates (RSRs) were evaluated. We applied the classification and definitions of the Central Brain Tumor Registry of the United States to our analysis for direct comparison with United States data.
Results
A total of 115,050 primary brain and CNS tumors were identified, and the ASR of all tumors was 22.01 per 100,000 individuals, which was lower than the 23.41 in the United States. However, the ASR of malignant tumors was significantly lower herein (4.27) than in the United States (7.08). Meningeal tumors were the most common histologic group among all tumors (ASR, 8.32). The 5-year RSR of all primary brain and other CNS tumors was 86.4%, and that of all malignant tumors was 44.1%, which was higher than the 35.8% observed in the United States. Among malignant tumors, glioblastomas had the lowest 5-year RSR (12.1%).
Conclusion
In Korea, malignant brain and other CNS tumors have a lower incidence and better survival outcome.

Citations

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    Arsene Daniel Nyalundja, Fabrice Mugisha, Claire Karekezi
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    Yeong Jin Kim, Kyung-Sub Moon, Sue Jee Park, Tae-Young Jung, In-Young Kim, Shin Jung
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  • Changes in the Epidemiologic Pattern of Primary CNS Tumors in Response to the Aging Population: An Updated Nationwide Cancer Registry Data in the Republic of Korea
    Yoon Hwan Byun, Johyun Ha, Ho Kang, Chul-Kee Park, Kyu-Won Jung, Heon Yoo
    JCO Global Oncology.2024;[Epub]     CrossRef
  • Surgical indications and outcomes of the endoscopic endonasal approach for brain tumors in older adults in Korea: a retrospective study
    Sun Mo Nam, Yoon Hwan Byun, Jung Hee Kim, Min-Sung Kim, Chul-Kee Park, Yong Hwy Kim
    Journal of Korean Society of Geriatric Neurosurgery.2024; 20(1): 21.     CrossRef
  • Bevacizumab Alone Versus Bevacizumab Plus Irinotecan in Patients With Recurrent Glioblastoma: A Nationwide Population-Based Study
    Yeonhu Lee, Eunyoung Lee, Tae Hoon Roh, Se-Hyuk Kim
    Journal of Korean Medical Science.2024;[Epub]     CrossRef
  • Survival After Newly-Diagnosed High-Grade Glioma Surgery: What Can We Learn From the French National Healthcare Database?
    Charles Champeaux Depond, Luc Bauchet, Dahmane Elhairech, Philippe Tuppin, Vincent Jecko, Joconde Weller, Philippe Metellus
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    Rina Di Bonaventura, Liverana Lauretti, Maurizio Martini, Tonia Cenci, Giuliano Di Monaco, Davide Palombi, Giovanni Maria Ceccarelli, Silvia Chiesa, Marco Gessi, Alessia Granitto, Alessio Albanese, Luigi Maria Larocca, Quintino Giorgio D’Alessandris, Robe
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    Natalia Kremenevski, Michael Buchfelder, Nirjhar Hore
    Current Oncology Reports.2023; 25(7): 765.     CrossRef
  • Decreased income, unemployment, and disability after craniotomy for brain tumor removal: a South Korean nationwide cohort study
    Tak Kyu Oh, In-Ae Song, Ji-Eyon Kwon, Solyi Lee, Hey-Ran Choi, Young-Tae Jeon
    Supportive Care in Cancer.2022; 30(2): 1663.     CrossRef
  • Association between surgical volume and outcomes after craniotomy for brain tumor removal: A South Korean nationwide cohort study
    Hey-ran Choi, In-Ae Song, Tak Kyu Oh
    Journal of Clinical Neuroscience.2022; 100: 75.     CrossRef
  • The comparative burden of brain and central nervous system cancers from 1990 to 2019 between China and the United States and predicting the future burden
    Jiajia Huang, Hanmei Li, Hualing Yan, Fen-Xiang Li, Mai Tang, Da-Lin Lu
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Anaplastic Meningioma: Clinical Characteristics, Prognostic Factors and Survival Outcome
    Dong Ok Seo, Sang Woo Song, Young-Hoon Kim, Chang-Ki Hong, Jeong Hoon Kim
    Brain Tumor Research and Treatment.2022; 10(4): 244.     CrossRef
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    Brain & Neurorehabilitation.2022;[Epub]     CrossRef
  • The epidemiology series of brain-related disorders in Mongolia: nationwide registry-based epidemiological study on CNS tumours in Mongolia, 2015–2019
    Tuvshingerel Sandagdorj, Undarmaa Tudev, Otgonbold Jamiyandorj, Takakazu Oka, Battuvshin Lkhagvasuren
    Journal of Integrative Neuroscience.2022;[Epub]     CrossRef
  • Depression and mortality after craniotomy for brain tumor removal: A Nationwide cohort study in South Korea
    Tak Kyu Oh, In-Ae Song, Hye Yoon Park, Young-Tae Jeon
    Journal of Affective Disorders.2021; 295: 291.     CrossRef
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Nationwide Population-Based Incidence and Survival Rates of Malignant Central Nervous System Germ Cell Tumors in Korea, 2005-2012
Seung Hoon Lee, Kyu-Won Jung, Johyun Ha, Chang-Mo Oh, Hyeseon Kim, Hyeon Jin Park, Heon Yoo, Young-Joo Won
Cancer Res Treat. 2017;49(2):494-501.   Published online August 24, 2016
DOI: https://doi.org/10.4143/crt.2016.129
AbstractAbstract PDFPubReaderePub
Purpose
Malignant central nervous system (CNS) germ cell tumors (GCTs), although rare, are thought to occur more frequently among Asians. However, a recent population-based study revealed no differences in GCT incidence between Asians and Caucasians. Therefore, this study was conducted to determine the incidence and survival rates of CNS GCTs using the national cancer incidence database, and to compare these rates to those in the United States and Japan.
Materials and Methods
We extracted CNS GCT patients diagnosed between 2005 and 2012 from the Korea Central Cancer Registry database. Age-standardized rates (ASRs), annual percentage change, and the male-female incidence rate ratios (IRRs) were calculated. To estimate the survival rate, we used data for patients diagnosed between 2005 and 2010 and followed their cases until December 31, 2013.
Results
The ASR for CNS GCT between 2005 and 2012 was 0.179 per 100,000 (95% confidence interval, 0.166 to 0.193), with an overall male-to-female (M:F) IRR of 2.95:1. However, when stratified by site, the M:F IRR was 13.62:1 for tumors of the pineal region and 1.87:1 for those located in nonpineal regions. The most frequent histologic type was germinoma (76.0%), and the most frequent location was the suprasellar region (48.5%). The 5-year survival rate of germinoma patients was 95.3%.
Conclusion
The incidence rate of CNS GCTs in Korea during 2005-2012 was 0.179 per 100,000, which was similar to that of the Asian/Pacific Islander subpopulation in the United States. Moreover, the CNS GCT survival rate in Korea was similar to rates in Japan and the United States.

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Population-based Incidence and Survival for Primary Central Nervous System Lymphoma in Korea, 1999-2009
Sang-Hoon Shin, Kyu-Won Jung, Johyun Ha, Seung Hoon Lee, Young-Joo Won, Heon Yoo
Cancer Res Treat. 2015;47(4):569-574.   Published online February 12, 2015
DOI: https://doi.org/10.4143/crt.2014.085
AbstractAbstract PDFPubReaderePub
Purpose
Primary central nervous system lymphoma (PCNSL) is an uncommon brain tumor accounting for 2%-5% of all primary brain tumors. Few population-based analyses of survival for patients with PCNSL have been conducted, particularly in Asian countries. Materials and Methods Using the Korea National Cancer Incidence Database, 1,062 cases of PCNSL newly diagnosed from 1999 to 2009 were analyzed. The crude rate, age-standardized rate (ASR), and annual percent change were calculated. To estimate the observed survival, we restricted the data to between 1999 and 2007 and followed the cases until December 2010. The overall survival was estimated using the Kaplan-Meier method, and piecewise Poisson regression model.
Results
The ASR for PCNSL between 1999 and 2009 was 0.17 per 100,000, and the annual percent change from 1999 to 2009 was 8.8% (p < 0.001). The ASR of males was higher than that of females, and the older groups (60s or over) showed the largest increase in incidence rates. For all ages, the five-year survival from PCNSL was 29.9% between 1999 and 2007. Survival from PCNSL is known to show strong association with age at diagnosis. Conclusion These results are similar to those of previous studies. Our findings may be helpful to clinicians and patients in determining long-term prognoses for PCNSL.

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Incidence of Primary Spinal Cord, Spinal Meninges, and Cauda Equina Tumors in Korea, 2006-2010
Kyu-Won Jung, Kwang Hyon Park, Johyun Ha, Seung Hoon Lee, Young-Joo Won, Heon Yoo
Cancer Res Treat. 2015;47(2):166-172.   Published online October 30, 2014
DOI: https://doi.org/10.4143/crt.2014.017
AbstractAbstract PDFPubReaderePub
Purpose
Primary spinal cord and appendage tumors (PSCAT) originating from the spinal cord, spinal meninges, and cauda equina are uncommon. Worldwide, population-based cancer registry data are mostly based on malignant tumors only, which means few data are available on PSCATs, including non-malignant tumors. Therefore, the objective of this study was to provide information regarding the incidence of both non-malignant and malignant PSCATs in Korea on a national level. Materials and Methods Incidence of PSCATs was estimated from cases diagnosed between 2006 and 2010 using the National Cancer Incidence Database in Korea. Age-adjusted rates were calculated using the world standard population, and male-to-female rate ratios were calculated by histology type. Results Of all PSCATs registered (n=3,312), 86.6% were non-malignant. The overall age-adjusted incidence of PSCATs was 1.08 per 100,000 person-years, with an incidence of 0.99 per 100,000 in females and 1.15 in males. The most common site of PSCATs was the spinal cord (83.4%), followed by spinal meninges (16.1%) and cauda equina (0.5%). The most common histological type was neurilemmoma (41.3%), followed by meningiomas (20.1%) and ependymomas (7.6%). Men had significantly higher rates than women for ependymomas and lymphomas but had lower rates for meningiomas. Conclusion This study provides the first population-based analysis of PSCATs in Korea.

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