Purpose
The purpose of this study was to determine the epidemiologic characteristics and survival of patients with primary brain and other central nervous system (CNS) tumors in Korea and to compare our findings with those from the United States.
Materials and Methods
We collected data on primary brain and CNS tumors diagnosed between 2007 and 2016 from the Korea Central Cancer Registry. The age-standardized incidence rates (ASRs) and 5-year relative survival rates (RSRs) were evaluated. We applied the classification and definitions of the Central Brain Tumor Registry of the United States to our analysis for direct comparison with United States data.
Results
A total of 115,050 primary brain and CNS tumors were identified, and the ASR of all tumors was 22.01 per 100,000 individuals, which was lower than the 23.41 in the United States. However, the ASR of malignant tumors was significantly lower herein (4.27) than in the United States (7.08). Meningeal tumors were the most common histologic group among all tumors (ASR, 8.32). The 5-year RSR of all primary brain and other CNS tumors was 86.4%, and that of all malignant tumors was 44.1%, which was higher than the 35.8% observed in the United States. Among malignant tumors, glioblastomas had the lowest 5-year RSR (12.1%).
Conclusion
In Korea, malignant brain and other CNS tumors have a lower incidence and better survival outcome.
Citations
Citations to this article as recorded by
Comparative analysis of hypofractionated short-course versus standard radiation therapy in elderly patients with glioblastoma: analysis of nationwide database Yong Kyun Won, Eun Seog Kim, In Young Jo, Hyuk-jin Oh, Sang Mi Lee, Ik Dong Yoo, Sun-pyo Hong, Jeong Won Lee, Jin Ho Song, Nayoon Kang, Hong Seok Jang Journal of Neuro-Oncology.2025; 171(2): 463. CrossRef
The Natural History and Treatment of Meningiomas: An Update Arsene Daniel Nyalundja, Fabrice Mugisha, Claire Karekezi Seminars in Neurology.2024; 44(01): 001. CrossRef
Gamma knife radiosurgery as primary management for intracranial meningioma identified as growing on serial imaging Yeong Jin Kim, Kyung-Sub Moon, Sue Jee Park, Tae-Young Jung, In-Young Kim, Shin Jung Medicine.2024; 103(5): e37082. CrossRef
Changes in the Epidemiologic Pattern of Primary CNS Tumors in Response to the Aging Population: An Updated Nationwide Cancer Registry Data in the Republic of Korea Yoon Hwan Byun, Johyun Ha, Ho Kang, Chul-Kee Park, Kyu-Won Jung, Heon Yoo JCO Global Oncology.2024;[Epub] CrossRef
Surgical indications and outcomes of the endoscopic endonasal approach for brain tumors in older adults in Korea: a retrospective study Sun Mo Nam, Yoon Hwan Byun, Jung Hee Kim, Min-Sung Kim, Chul-Kee Park, Yong Hwy Kim Journal of Korean Society of Geriatric Neurosurgery.2024; 20(1): 21. CrossRef
Bevacizumab Alone Versus Bevacizumab Plus Irinotecan in Patients With Recurrent Glioblastoma: A Nationwide Population-Based Study Yeonhu Lee, Eunyoung Lee, Tae Hoon Roh, Se-Hyuk Kim Journal of Korean Medical Science.2024;[Epub] CrossRef
Survival After Newly-Diagnosed High-Grade Glioma Surgery: What Can We Learn From the French National Healthcare Database? Charles Champeaux Depond, Luc Bauchet, Dahmane Elhairech, Philippe Tuppin, Vincent Jecko, Joconde Weller, Philippe Metellus Brain Tumor Research and Treatment.2024; 12(3): 162. CrossRef
18F-FET PET/CT can aid in diagnosing patients with indeterminate MRI findings for brain tumors: a prospective study Sheng-Chieh Chan, Tsung-Lang Chiu, Shu-Hang Ng, Hung-Wen Kao, Sheng-Tzung Tsai, Shu-Hsin Liu Annals of Nuclear Medicine.2024;[Epub] CrossRef
Optimal timing of chemoradiation after resection or biopsy of glioblastomas: a nationwide population-based study Dongeun Lee, Eunyoung Lee, Tae Hoon Roh, Se-Hyuk Kim BMC Cancer.2024;[Epub] CrossRef
Association between insomnia disorder and mortality among patients who underwent craniotomy for brain tumor resection: a South Korean nationwide cohort study Hey-ran Choi, In-Ae Song, Hye Yoon Park, Tak Kyu Oh Sleep and Breathing.2023; 27(1): 329. CrossRef
Fully Automated MRI Segmentation and Volumetric Measurement of Intracranial Meningioma Using Deep Learning Ho Kang, Joseph Nathanael Witanto, Kevin Pratama, Doohee Lee, Kyu Sung Choi, Seung Hong Choi, Kyung‐Min Kim, Min‐Sung Kim, Jin Wook Kim, Yong Hwy Kim, Sang Joon Park, Chul‐Kee Park Journal of Magnetic Resonance Imaging.2023; 57(3): 871. CrossRef
Patterns of care and survival of Chinese glioblastoma patients in the temozolomide era: a Hong Kong population-level analysis over a 14-year period Peter Y M Woo, Stephen Yau, Tai-Chung Lam, Jenny K S Pu, Lai-Fung Li, Louisa C Y Lui, Danny T M Chan, Herbert H F Loong, Michael W Y Lee, Rebecca Yeung, Carol C H Kwok, Siu-Kie Au, Tze-Ching Tan, Amanda N C Kan, Tony K T Chan, Calvin H K Mak, Henry K F Ma Neuro-Oncology Practice.2023; 10(1): 50. CrossRef
Paths of Evolution of Progressive Anaplastic Meningiomas: A Clinical and Molecular Pathology Study Rina Di Bonaventura, Liverana Lauretti, Maurizio Martini, Tonia Cenci, Giuliano Di Monaco, Davide Palombi, Giovanni Maria Ceccarelli, Silvia Chiesa, Marco Gessi, Alessia Granitto, Alessio Albanese, Luigi Maria Larocca, Quintino Giorgio D’Alessandris, Robe Journal of Personalized Medicine.2023; 13(2): 206. CrossRef
Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management Natalia Kremenevski, Michael Buchfelder, Nirjhar Hore Current Oncology Reports.2023; 25(7): 765. CrossRef
Decreased income, unemployment, and disability after craniotomy for brain tumor removal: a South Korean nationwide cohort study Tak Kyu Oh, In-Ae Song, Ji-Eyon Kwon, Solyi Lee, Hey-Ran Choi, Young-Tae Jeon Supportive Care in Cancer.2022; 30(2): 1663. CrossRef
Association between surgical volume and outcomes after craniotomy for brain tumor removal: A South Korean nationwide cohort study Hey-ran Choi, In-Ae Song, Tak Kyu Oh Journal of Clinical Neuroscience.2022; 100: 75. CrossRef
The comparative burden of brain and central nervous system cancers from 1990 to 2019 between China and the United States and predicting the future burden Jiajia Huang, Hanmei Li, Hualing Yan, Fen-Xiang Li, Mai Tang, Da-Lin Lu Frontiers in Public Health.2022;[Epub] CrossRef
Anaplastic Meningioma: Clinical Characteristics, Prognostic Factors and Survival Outcome Dong Ok Seo, Sang Woo Song, Young-Hoon Kim, Chang-Ki Hong, Jeong Hoon Kim Brain Tumor Research and Treatment.2022; 10(4): 244. CrossRef
Classification and Diagnosis of Adult Glioma: A Scoping Review Yoon Hwan Byun, Chul-Kee Park Brain & Neurorehabilitation.2022;[Epub] CrossRef
The epidemiology series of brain-related disorders in Mongolia: nationwide registry-based epidemiological study on CNS tumours in Mongolia, 2015–2019 Tuvshingerel Sandagdorj, Undarmaa Tudev, Otgonbold Jamiyandorj, Takakazu Oka, Battuvshin Lkhagvasuren Journal of Integrative Neuroscience.2022;[Epub] CrossRef
Depression and mortality after craniotomy for brain tumor removal: A Nationwide cohort study in South Korea Tak Kyu Oh, In-Ae Song, Hye Yoon Park, Young-Tae Jeon Journal of Affective Disorders.2021; 295: 291. CrossRef
Purpose
Malignant central nervous system (CNS) germ cell tumors (GCTs), although rare, are thought to occur more frequently among Asians. However, a recent population-based study revealed no differences in GCT incidence between Asians and Caucasians. Therefore, this study was conducted to determine the incidence and survival rates of CNS GCTs using the national cancer incidence database, and to compare these rates to those in the United States and Japan.
Materials and Methods
We extracted CNS GCT patients diagnosed between 2005 and 2012 from the Korea Central Cancer Registry database. Age-standardized rates (ASRs), annual percentage change, and the male-female incidence rate ratios (IRRs) were calculated. To estimate the survival rate, we used data for patients diagnosed between 2005 and 2010 and followed their cases until December 31, 2013.
Results
The ASR for CNS GCT between 2005 and 2012 was 0.179 per 100,000 (95% confidence interval, 0.166 to 0.193), with an overall male-to-female (M:F) IRR of 2.95:1. However, when stratified by site, the M:F IRR was 13.62:1 for tumors of the pineal region and 1.87:1 for those located in nonpineal regions. The most frequent histologic type was germinoma (76.0%), and the most frequent location was the suprasellar region (48.5%). The 5-year survival rate of germinoma patients was 95.3%.
Conclusion
The incidence rate of CNS GCTs in Korea during 2005-2012 was 0.179 per 100,000, which was similar to that of the Asian/Pacific Islander subpopulation in the United States. Moreover, the CNS GCT survival rate in Korea was similar to rates in Japan and the United States.
Citations
Citations to this article as recorded by
Pediatric sellar teratoma – Case report and review of the literature Katja Kürner, Ladina Greuter, Michel Roethlisberger, Yves Brand, Stephan Frank, Raphael Guzman, Jehuda Soleman Child's Nervous System.2024; 40(4): 1259. CrossRef
Novel molecular subtypes of intracranial germ cell tumors expand therapeutic opportunities Bo Li, Shuang Zhao, Shouwei Li, Chunde Li, Wei Liu, Lin Li, Bowen Cui, Xing Liu, Huiyuan Chen, Jing Zhang, Yin Ren, Fei Liu, Ming Yang, Tao Jiang, Yu Liu, Xiaoguang Qiu Neuro-Oncology.2024; 26(7): 1335. CrossRef
Effect of delayed diagnosis on neuroendocrine function in individuals with suprasellar germ cell tumors Tao Tong, Jian Xu, Han Chen, Caiyan Mo, Dan Liang, Liyong Zhong Frontiers in Endocrinology.2024;[Epub] CrossRef
A deep learning model for differentiating paediatric intracranial germ cell tumour subtypes and predicting survival with MRI: a multicentre prospective study Yanong Li, Zhizheng Zhuo, Jinyuan Weng, Sven Haller, Harrison X. Bai, Bo Li, Xing Liu, Mingwang Zhu, Zheng Wang, Jane Li, Xiaoguang Qiu, Yaou Liu BMC Medicine.2024;[Epub] CrossRef
High detection rate of circulating-tumor DNA from cerebrospinal fluid of children with central nervous system germ cell tumors Yoshiko Nakano, Ian Burns, Liana Nobre, Robert Siddaway, Mansuba Rana, Cody Nesvick, Andrew Bondoc, Michelle Ku, Richard Yuditskiy, Dennis T. L. Ku, Matthew M. K. Shing, Kevin K. F. Cheng, Ho-Keung Ng, Anirban Das, Julie Bennett, Vijay Ramaswamy, Annie Hu Acta Neuropathologica Communications.2024;[Epub] CrossRef
The global prevalence of primary central nervous system tumors: a systematic review and meta-analysis Nader Salari, Hooman Ghasemi, Reza Fatahian, Kamran Mansouri, Sadat Dokaneheifard, Mohammad hossain Shiri, Mahvan Hemmati, Masoud Mohammadi European Journal of Medical Research.2023;[Epub] CrossRef
Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management Natalia Kremenevski, Michael Buchfelder, Nirjhar Hore Current Oncology Reports.2023; 25(7): 765. CrossRef
Diagnostik der Keimzelltumoren Armin Bachhuber Die Radiologie.2023; 63(8): 598. CrossRef
Methionine metabolism and endocrine function of the pituitary gland in patients with suprasellar germinoma Hwanhee Lee, Ji Won Lee, Hee Won Cho, Yearn Seong Choe, Kyung-Han Lee, Joon Young Choi, Ki Woong Sung, Seung Hwan Moon, Liza Das PLOS ONE.2023; 18(7): e0288528. CrossRef
The role of neoadjuvant chemotherapy in the management of metastatic central nervous system germinoma: A meta‐analysis Mohammad H. Abu‐Arja, Margaret S. Shatara, M. Fatih Okcu, Susan L. McGovern, Jack M. Su, Mohamed S. Abdelbaki Pediatric Blood & Cancer.2023;[Epub] CrossRef
Treatment outcomes for response-based radiotherapy in children and adolescents with central nervous system germinoma: a prospective study Chenggong Zeng, Qunying Yang, Zhuoran Li, Zhiqing Wei, Tingting Chen, Meiling Deng, Jian Wang, Juan Wang, Feifei Sun, Junting Huang, Suying Lu, Jia Zhu, Xiaofei Sun, Zijun Zhen Journal of Neuro-Oncology.2023; 164(3): 643. CrossRef
Intracranial Germ Cell Tumors Teri Danielle You Ying Yeoh, Vincent Nga, Miriam Kimpo, Simon S. Lo, Balamurugan Vellayappan Seminars in Neurology.2023; 43(06): 897. CrossRef
A Pineal Germinoma with Rapid Enlargement following Tumor Resection Chia-Jung Hsu, Hsiang-Chih Liao, Dueng-Yuan Hueng, Kuan-Yin Tseng Diagnostics.2023; 13(23): 3579. CrossRef
Survival outcomes, hematologic complications and growth impairment after sequential chemoradiotherapy in intracranial NGGCTs: a retrospective study Lei Wen, Juan Li, Mingyao Lai, Zhaoming Zhou, Qingjun Hu, Guanhua Deng, Changguo Shan, Ruyu Ai, Hainan Li, Ming Lu, Liang Zhang, Taihua Wu, Dan Zhu, Yuanyuan Chen, Longhua Chen, Linbo Cai, Cheng Zhou Strahlentherapie und Onkologie.2022; 198(5): 458. CrossRef
Depression, anxiety and health-related quality of life in paediatric intracranial germ cell tumor survivors Wenyi Lv, Bo Li, Jin Feng, Li Chen, Xiaoguang Qiu, Shuai Liu Health and Quality of Life Outcomes.2022;[Epub] CrossRef
Hypothalamic syndrome Hermann L. Müller, Maithé Tauber, Elizabeth A. Lawson, Jale Özyurt, Brigitte Bison, Juan-Pedro Martinez-Barbera, Stephanie Puget, Thomas E. Merchant, Hanneke M. van Santen Nature Reviews Disease Primers.2022;[Epub] CrossRef
A GIANT GERMINOMA MIMICS HIGH-GRADE GLIOMA: A RARE FORM OF THALAMIC REGION TUMOR Dirga Rachmad Aprianto, Muhammad Arifin Parenrengi Wiadomości Lekarskie.2022; 75(8): 2036. CrossRef
Clinical Outcomes and Diagnostic Consistency of Serum and CSF Tumor Markers in Pediatric Intracranial Germ Cell Tumors in Thailand: A Multicenter Study Lalita Sathitsamitphong, Chalinee Monsereenusorn, Piti Techavichit, Kanjana Shotelersuk, Piradee Suwanpakdee, Piya Rujkijyanont, Pimlak Charoenkwan Global Pediatric Health.2022;[Epub] CrossRef
Neurological and endocrinological manifestations of 49 children with intracranial pure germinoma at initial diagnosis in Taiwan Hsin-Yuan Chang, Chiao-Fan Chiu, Shih-Ming Jung, Alex Mun-Ching Wong, Chieh-Tsai Wu, Fu-Sung Lo Pediatrics & Neonatology.2021; 62(1): 106. CrossRef
Management trends and outcomes of pineal germinoma in a multi-institutional Australian cohort Sean Stephens, Anna Kuchel, Robyn Cheuk, Hamish Alexander, Thomas Robertson, Thulasi Rajah, Quan Tran, Po-ling Inglis Journal of Clinical Neuroscience.2021; 90: 1. CrossRef
Characteristics of growth disturbances in patients with intracranial germinomas of different origins Bo Li, Jiayi Wang, Jiongxian Yang, Yanong Li, Yanwei Liu, Shuai Liu, Xiaoguang Qiu Child's Nervous System.2021; 37(8): 2531. CrossRef
A clinical approach to parasellar lesions in the transition age Emilia Sbardella, Giulia Puliani, Tiziana Feola, Riccardo Pofi, Rosa Pirchio, Franz Sesti, Federica Verdecchia, Daniele Gianfrilli, Daniel Moffat, Andrea M. Isidori, Ashley B. Grossman Journal of Neuroendocrinology.2021;[Epub] CrossRef
Incidence and outcomes of malignant ovarian germ cell tumors in Korea, 1999–2017 Meerim Park, Jiwon Lim, Jun Ah Lee, Hyeon Jin Park, Byung Kiu Park, Myong Cheol Lim, Sang-Yoon Park, Young-Joo Won Gynecologic Oncology.2021; 163(1): 79. CrossRef
Long-Term Outcomes and Sequelae Analysis of Intracranial Germinoma: Need to Reduce the Extended-Field Radiotherapy Volume and Dose to Minimize Late Sequelae Joo Ho Lee, Keun-Yong Eom, Ji Hoon Phi, Chul-Kee Park, Seung Ki Kim, Byung-Kyu Cho, Tae Min Kim, Dae Seog Heo, Kyung Taek Hong, Jung Yoon Choi, Hyoung Jin Kang, Hee Young Shin, Seung Hong Choi, Soon Tae Lee, Sung Hye Park, Kyu-Chang Wang, Il Han Kim Cancer Research and Treatment.2021; 53(4): 983. CrossRef
Symptom interval and treatment burden for patients with malignant central nervous system germ cell tumours James Hayden, Matthew J Murray, Ute Bartels, Thankamma Ajithkumar, Brinda Muthusamy, Anthony Penn, Gabriele Calaminus, James Nicholson Archives of Disease in Childhood.2020; 105(3): 247. CrossRef
Study Progress of Intracranial Germ Cell Tumors 晓红 高 Advances in Clinical Medicine.2020; 10(03): 270. CrossRef
Cerebrospinal fluid ctDNA and metabolites are informative biomarkers for the evaluation of CNS germ cell tumors Takeshi Takayasu, Mauli Shah, Antonio Dono, Yuanqing Yan, Roshan Borkar, Nagireddy Putluri, Jay-Jiguang Zhu, Seiji Hama, Fumiyuki Yamasaki, Hidetoshi Tahara, Kazuhiko Sugiyama, Kaoru Kurisu, Yoshua Esquenazi, Leomar Y. Ballester Scientific Reports.2020;[Epub] CrossRef
Canadian Pediatric Neuro-Oncology Standards of Practice Julie Bennett, Craig Erker, Lucie Lafay-Cousin, Vijay Ramaswamy, Juliette Hukin, Magimairajan I. Vanan, Sylvia Cheng, Hallie Coltin, Adriana Fonseca, Donna Johnston, Andrea Lo, Shayna Zelcer, Saima Alvi, Lynette Bowes, Josée Brossard, Janie Charlebois, Da Frontiers in Oncology.2020;[Epub] CrossRef
Critical review of the management of primary central nervous nongerminomatous germ cell tumors Mohammad H. Abu Arja, Eric Bouffet, Jonathan L. Finlay, Mohamed S. AbdelBaki Pediatric Blood & Cancer.2019;[Epub] CrossRef
Emergency irradiation of 3.4Gy/2f in pineal gland germinoma patients with symptomatic hydrocephalus Bo Li, Youqi Li, Chunde Li, Yanwei Liu, Shuai Liu, Xiaoguang Qiu, Shiqi Luo Chinese Neurosurgical Journal.2019;[Epub] CrossRef
A Nationwide, Population-Based Epidemiologic Study of Childhood Brain Tumors in Korea, 2005–2014: A Comparison with United States Data Ji-Man Kang, Johyun Ha, Eun Kyung Hong, Hee Young Ju, Byung Kiu Park, Sang-Hoon Shin, Young-Joo Won, Kyu-Won Jung, Hyeon Jin Park Cancer Epidemiology, Biomarkers & Prevention.2019; 28(2): 409. CrossRef
Central Nervous System Germ Cell Tumors: A Review of the Literature Ziren Kong, Yaning Wang, Congxin Dai, Yong Yao, Wenbin Ma, Yu Wang Journal of Child Neurology.2018; 33(9): 610. CrossRef
Purpose Primary central nervous system lymphoma (PCNSL) is an uncommon brain tumor accounting for 2%-5% of all primary brain tumors. Few population-based analyses of survival for patients with PCNSL have been conducted, particularly in Asian countries. Materials and Methods Using the Korea National Cancer Incidence Database, 1,062 cases of PCNSL newly diagnosed from 1999 to 2009 were analyzed. The crude rate, age-standardized rate (ASR), and annual percent change were calculated. To estimate the observed survival, we restricted the data to between 1999 and 2007 and followed the cases until December 2010. The overall survival was estimated using the Kaplan-Meier method, and piecewise Poisson regression model.
Results The ASR for PCNSL between 1999 and 2009 was 0.17 per 100,000, and the annual percent change from 1999 to 2009 was 8.8% (p < 0.001). The ASR of males was higher than that of females, and the older groups (60s or over) showed the largest increase in incidence rates. For all ages, the five-year survival from PCNSL was 29.9% between 1999 and 2007. Survival from PCNSL is known to show strong association with age at diagnosis. Conclusion These results are similar to those of previous studies. Our findings may be helpful to clinicians and patients in determining long-term prognoses for PCNSL.
Citations
Citations to this article as recorded by
All-cause and tumor-specific mortality trends in elderly primary central nervous system lymphoma (PCNSL) patients: a surveillance, epidemiology, and end results (SEER) analysis Taylor FURST, Haydn HOFFMAN, Lawrence S. CHIN Journal of Neurosurgical Sciences.2024;[Epub] CrossRef
Intrathecal IgM synthesis as a diagnostic marker in patients with suspected CNS lymphoma Raphael Reinecke, Kolja Jahnke, Martha Foltyn‐Dumitru, Karsten Lachner, Moritz Armbrust, Katharina J. Weber, Pia S. Zeiner, Marcus Czabanka, Uta Brunnberg, Sylvia Hartmann, Joachim P. Steinbach, Michael W. Ronellenfitsch Journal of Neurochemistry.2024; 168(6): 1157. CrossRef
Targeting the tumor microenvironment in primary central nervous system lymphoma: Implications for prognosis Han Shi, Xuefei Sun, Yuchen Wu, Qu Cui, Shengjun Sun, Nan Ji, Yuanbo Liu Journal of Clinical Neuroscience.2024; 124: 36. CrossRef
Defining MRI-based follow-up protocol for primary central nervous system lymphoma Inka K. Puhakka, Kaisa L. Sunela, Aino L. Rönkä, Aino M. Rajamäki, Ulla-Mari Arkko, Tuula M. Klaavuniemi, Milla E.L Kuusisto, Pekka A. Jäkälä, Tuomas A. Selander, Hanne K. Kuitunen, Anne-Mari Kantanen, Outi M. Kuittinen Annals of Hematology.2024;[Epub] CrossRef
Long term outcomes in older patients with primary central nervous system lymphoma: an analysis of the Texas Cancer Registry Ethan A. Burns, Cesar Gentille Sanchez, Sunil Mathur, Carlo Guerrero, Ibrahim N. Muhsen, Humaira Sarfraz, Chih-Chi Andrew Hu, Chih-Hang Anthony Tang, Shilpan S. Shah, Ivo W. Tremont, Bin Teh, Siddhartha Ganguly, Sai Ravi Kiran Pingali Annals of Hematology.2023; 102(5): 1111. CrossRef
Exosomal miR-200c and miR-141 as cerebrospinal fluid biopsy biomarkers for the response to chemotherapy in primary central nervous system lymphoma Yao Hu, Qingyun Zhang, Zhiyuan Wu, Kun Chen, Xiao Xu, Weizhe Ma, Bobin Chen, Limin Jin, Ming Guan Discover Oncology.2023;[Epub] CrossRef
Primary central nervous system lymphoma high incidence and poor survival in Finnish population-based analysis Inka Puhakka, Hanne Kuitunen, Pekka Jäkälä, Eila Sonkajärvi, Taina Turpeenniemi-Hujanen, Aino Rönkä, Tuomas Selander, Miika Korhonen, Outi Kuittinen BMC Cancer.2022;[Epub] CrossRef
Use of rituximab, temozolomide, and radiation in recurrent and refractory primary central nervous system lymphoma in the Philippines: a retrospective analysis Julette Marie F Batara, Almira Doreen Abigail O Apor, Christianne V Mojica, Mark Willy L Mondia Neuro-Oncology Advances.2022;[Epub] CrossRef
The International Vitreoretinal B-Cell Lymphoma Registry: a protocol paper Justine R Smith, Alexandra L Farrall, Janet L Davis, Joke H de Boer, Anthony J Hall, Manabu Mochizuki, H Nida Sen, Hiroshi Takase, Ninette H ten Dam-van Loon, Valérie Touitou, Daniel V Vasconcelos-Santos, David J Wilson, Steven Yeh, Mark H B Radford BMJ Open.2022; 12(7): e060701. CrossRef
Changing Incidence and Survival of Primary Central Nervous System Lymphoma in Australia: A 33-Year National Population-Based Study Alexandra L. Farrall, Justine R. Smith Cancers.2021; 13(3): 403. CrossRef
Eye involvement in primary central nervous system lymphoma Alexandra L. Farrall, Justine R. Smith Survey of Ophthalmology.2020; 65(5): 548. CrossRef
Characteristics, management and outcome of DLBCL patients, presenting with simultaneous systemic and CNS disease at diagnosis: A retrospective multicenter study Chava Perry, Sharon Ben Barouch, Neta Goldschmidt, Nadav Sarid, Yair Herishanu, Lev Shvidel, Osnat Bairey, Noa Lavi, Netanel Horowitz, Avraham Avigdor, Eyal Lebel, Orit Sofer, Ron Ram, Irit Avivi American Journal of Hematology.2019; 94(9): 992. CrossRef
Improved survival in primary central nervous system lymphoma up to age 70 only: a population-based study on incidence, primary treatment and survival in the Netherlands, 1989–2015 M van der Meulen, A G Dinmohamed, O Visser, J K Doorduijn, J E C Bromberg Leukemia.2017; 31(8): 1822. CrossRef
Role of radiation therapy in primary central nervous system lymphoma Hyeon Kang Koh, Il Han Kim, Tae Min Kim, Do Hoon Lim, Dongryul Oh, Jae Ho Cho, Woo-Chul Kim, Jin Hee Kim, Woong-Ki Chung, Bae-Kwon Jeong, Ki Mun Kang, Semie Hong, Chang-Ok Suh, In Ah Kim Journal of Neuro-Oncology.2017; 135(3): 629. CrossRef
Purpose Primary spinal cord and appendage tumors (PSCAT) originating from the spinal cord, spinal meninges, and cauda equina are uncommon. Worldwide, population-based cancer registry data are mostly based on malignant tumors only, which means few data are available on PSCATs, including non-malignant tumors. Therefore, the objective of this study was to provide information regarding the incidence of both non-malignant and malignant PSCATs in Korea on a national level. Materials and Methods Incidence of PSCATs was estimated from cases diagnosed between 2006 and 2010 using the National Cancer Incidence Database in Korea. Age-adjusted rates were calculated using the world standard population, and male-to-female rate ratios were calculated by histology type. Results Of all PSCATs registered (n=3,312), 86.6% were non-malignant. The overall age-adjusted incidence of PSCATs was 1.08 per 100,000 person-years, with an incidence of 0.99 per 100,000 in females and 1.15 in males. The most common site of PSCATs was the spinal cord (83.4%), followed by spinal meninges (16.1%) and cauda equina (0.5%). The most common histological type was neurilemmoma (41.3%), followed by meningiomas (20.1%) and ependymomas (7.6%). Men had significantly higher rates than women for ependymomas and lymphomas but had lower rates for meningiomas. Conclusion This study provides the first population-based analysis of PSCATs in Korea.
Citations
Citations to this article as recorded by
Surgical Strategy for Dumbbell-Shaped Cervical Schwannoma at the Vicinity of the Vertebral Artery: The Utilization of Anatomic Layer Hangeul Park, Sum Kim, Young-Rak Kim, Sung-Hye Park, John M. Rhee, Chun Kee Chung, Jun-Hoe Kim, Chang-Hyun Lee, Kyoung-Tae Kim, Chi Heon Kim Operative Neurosurgery.2025; 28(2): 165. CrossRef
Multiple Medullary Schwannoma Associated with Lumbar Disc Herniation and Cauda Equina Syndrome: Case Report Anibal Rodrigues Neto, Bianca Bicalho, Giovanna Maria Varandas, Adriano Torres Antonucci, Gabriel Gomes Freitas de Castro, Shiro Manoel Shimoakoishi de Arruda, Marcel Schiavini, Lutero Cleuler Moraes dos Santos, Márcio Francisco Lehmann, Francisco Spessat Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery.2024; 43(02): e117. CrossRef
Is laminectomy necessary for C1-C2 epidural schwannomas? Tae-Shin Kim, Woon Tak Yuh, Junghoon Han, Junhoe Kim, Chang-Hyun Lee, Chi Heon Kim, Chun Kee Chung Acta Neurochirurgica.2023; 165(10): 3065. CrossRef
Primary Benign Tumors of the Spinal Canal José Alberto Carlos-Escalante, Ángel Antonio Paz-López, Bernardo Cacho-Díaz, Guillermo Pacheco-Cuellar, Gervith Reyes-Soto, Talia Wegman-Ostrosky World Neurosurgery.2022; 164: 178. CrossRef
Spinal biopsies: a clinicopathologic review of 53 cases diagnosed between 2011 and 2018 at a tertiary hospital in Kampala, Uganda James J. Yahaya Egyptian Journal of Neurosurgery.2021;[Epub] CrossRef
Racial and Ethnic Disparities in the Inpatient Management of Primary Spinal Cord Tumors Ryan G. Chiu, Blake E. Murphy, Amy Zhu, Ankit I. Mehta World Neurosurgery.2020; 140: e175. CrossRef
Primary Central Nerve System Lymphoma Affecting the Lumbosacral Nerve Root: A Case Report Junhyung Kim, Bonggyu Ryu, Seung-Jae Hyun, Ki-Jeong Kim The Nerve.2020; 6(2): 110. CrossRef
Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI): an overview of initial enrollment and demographics Rachel E. Tsolinas, John F. Burke, Anthony M. DiGiorgio, Leigh H. Thomas, Xuan Duong-Fernandez, Mark H. Harris, John K. Yue, Ethan A. Winkler, Catherine G. Suen, Lisa U. Pascual, Adam R. Ferguson, J. Russell Huie, Jonathan Z. Pan, Debra D. Hemmerle, Vinee Neurosurgical Focus.2020; 48(5): E6. CrossRef
A Nation-Wide Epidemiological Study of Newly Diagnosed Primary Spine Tumor in the Adult Korean Population, 2009-2011 Seil Sohn, Jinhee Kim, Chun Kee Chung, Na Rae Lee, Moon Jun Sohn, Sung Hwan Kim Journal of Korean Neurosurgical Society.2017; 60(2): 195. CrossRef
Nationwide epidemiology and healthcare utilization of spine tumor patients in the adult Korean population, 2009–2012 Seil Sohn, Jinhee Kim, Chun Kee Chung, Na-Rye Lee, Eunjung Park, Ung-Kyu Chang, Moon Jun Sohn, Sung Hwan Kim Neuro-Oncology Practice.2015; 2(2): 93. CrossRef