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34 "Jin Cheon Kim"
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Original Article
Gastrointestinal cancer
Radiofrequency Ablation versus Stereotactic Body Radiation Therapy in the Treatment of Colorectal Cancer Liver Metastases
Jesang Yu, Dong Hwan Kim, Jungbok Lee, Yong Moon Shin, Jong Hoon Kim, Sang Min Yoon, Jinhong Jung, Jin Cheon Kim, Chang Sik Yu, Seok-Byung Lim, In Ja Park, Tae Won Kim, Yong Sang Hong, Sun Young Kim, Jeong Eun Kim, Jin-hong Park, So Yeon Kim
Cancer Res Treat. 2022;54(3):850-859.   Published online October 13, 2021
DOI: https://doi.org/10.4143/crt.2021.674
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
This study aimed to compare the treatment outcomes of radiofrequency ablation (RFA) and stereotactic body radiation therapy (SBRT) for colorectal cancer liver metastases (CRLM) and to determine the favorable treatment modality according to tumor characteristics.
Materials and Methods
We retrospectively analyzed the records of 222 colorectal cancer patients with 330 CRLM who underwent RFA (268 tumors in 178 patients) or SBRT (62 tumors in 44 patients) between 2007 and 2014. Kaplan–Meier method and Cox models were used by adjusting with inverse probability of treatment weighting (IPTW).
Results
The median follow-up duration was 30.5 months. The median tumor size was significantly smaller in the RFA group than in the SBRT group (1.5 cm vs 2.3 cm, p<0.001). In IPTW-adjusted analysis, difference in treatment modality was not associated with significant differences in 1-year and 3-year recurrence-free survival (35% vs 43%, 22% vs 23%; p=0.198), overall survival (96% vs 91%, 58% vs 56%; p=0.508), and freedom from local progression (FFLP; 90% vs 72%, 78% vs 60%; p=0.106). Significant interaction effect between the treatment modality and tumor size was observed for FFLP (p=0.001). In IPTW-adjusted subgroup analysis of patients with tumor size >2 cm, the SBRT group had a higher FFLP compared with the RFA group (HR, 0.153; p<0.001).
Conclusion
SBRT and RFA showed similar local control in the treatment of patients with CRLM. Tumor size was an independent prognostic factor for local control and SBRT may be preferred for larger tumors.

Citations

Citations to this article as recorded by  
  • Ablative techniques in colorectal liver metastases: A systematic review, descriptive summary of practice, and recommendations for optimal data reporting
    Wee Han Ng, Catarina Machado, Alice Rooney, Robert Jones, Jonathan Rees, Samir Pathak
    European Journal of Surgical Oncology.2025; 51(2): 109487.     CrossRef
  • Effects of maximum dose on local control after stereotactic body radiotherapy for oligometastatic tumors of colorectal cancer
    Su Jin Kang, Jongmoo Park, Gyu-Seog Choi, Jong Gwang Kim, Jun Seok Park, Hye Jin Kim, Jin Ho Baek, Byung Woog Kang, An Na Seo, Shin-Hyung Park, Bong Kyung Bae, Min Kyu Kang, Soo Yeun Park, Devarati Mitra
    PLOS ONE.2025; 20(1): e0313438.     CrossRef
  • Role of Radiotherapy in Liver Tumors: Recent Update
    Vito Filbert Jayalie, Merinda, Herryanto Lumbantobing, Sudibio, Julius Oentario, Hendriyo, Sry Suryani Widjaja
    Forum of Clinical Oncology.2025;[Epub]     CrossRef
  • Treatment of Oligometastatic GI Cancers
    Clayton T. Marcinak, Patrick B. Schwartz, Mustafa M. Basree, Newton Hurst, Michael Bassetti, Jeremy D. Kratz, Nataliya V. Uboha
    American Society of Clinical Oncology Educational Book.2024;[Epub]     CrossRef
  • Stereotactic radiotherapy for liver oligometastases: a pooled analysis following the estro/eortc consensus recommendations
    D. Pezzulla, G. Chiloiro, E. M. Lima, G. Macchia, C. Romano, S. Reina, G. Panza, S. Cilla, A. G. Morganti, F. Cellini, M. A. Gambacorta, F. Deodato
    Clinical & Experimental Metastasis.2024; 41(5): 667.     CrossRef
  • Interventionelle Therapieoptionen bei oligometastasierten Tumoren
    Max Seidensticker
    Forum.2024; 39(5): 340.     CrossRef
  • Efficacy and safety of B-ultrasound-guided radiofrequency ablation in the treatment of primary liver cancer: Systematic review and meta-analysis
    Xiong Zhang, Hong-Yi Zhu, Ming Yuan
    World Journal of Gastrointestinal Surgery.2024; 16(9): 2986.     CrossRef
  • Analysis of alkaline phosphatase and γ-glutamyltransferase after radiofrequency ablation of primary liver cancer: A retrospective study
    Wen-Yu Huang, Sheng Zheng, Dan Zhu, Ying-Lang Zeng, Juan Yang, Xue-Li Zeng, Pei Liu, Shun-Ling Zhang, Ming Yuan, Zhi-Xia Wang
    World Journal of Gastrointestinal Surgery.2024; 16(9): 2860.     CrossRef
  • Evidence-based clinical recommendations for hypofractionated radiotherapy: exploring efficacy and safety - Part 4: Liver and locally recurrent rectal cancer
    Hwa Kyung Byun, Gyu Sang Yoo, Soo-Yoon Sung, Jin-Ho Song, Byoung Hyuck Kim, Yoo-Kang Kwak, Yeon Joo Kim, Yeon-Sil Kim, Kyung Su Kim
    Radiation Oncology Journal.2024; 42(4): 247.     CrossRef
  • Recent trends in radiotherapy use for major cancers in Korea
    Kyungmi Yang, Jeong Eun Lee, Won Park, Yong Chan Ahn, Seung Jae Huh
    Japanese Journal of Clinical Oncology.2023; 53(12): 1177.     CrossRef
  • Combination of endoscopic ultrasound-guided radiofrequency ablation and adaptive radiation therapy for the treatment of lymph node metastases from colon adenocarcinoma: A case report
    Federica Borrelli de Andreis, Maria Alessandra Calegari, Angela Romano, Maria Gabriella Brizi, Luigi Sofo, Ivo Boskoski, Guido Costamagna, Fabia Attili
    Current Problems in Cancer: Case Reports.2023; 9: 100216.     CrossRef
  • Comparison of radiofrequency ablation and ablative external radiotherapy for the treatment of intrahepatic malignancies: A hybrid meta-analysis
    Chai Hong Rim, Jung Sue Lee, Soo Yeon Kim, Jinsil Seong
    JHEP Reports.2023; 5(1): 100594.     CrossRef
  • Metastasis-Directed Local Therapy of Hepatic Oligometastasis from Colorectal Cancer and Future Perspective in Radiation Therapy
    Gyu Sang Yoo, Chai Hong Rim, Won Kyung Cho, Jae-Uk Jeong, Eui Kyu Chie, Hyeon-Min Cho, Jun Won Um, Yong Chan Ahn, Jong Hoon Lee
    Cancer Research and Treatment.2023; 55(3): 707.     CrossRef
  • Local Control Following Stereotactic Body Radiation Therapy for Liver Oligometastases: Lessons from a Quarter Century
    Sara Mheid, Stefan Allen, Sylvia S. W. Ng, William A. Hall, Nina N. Sanford, Todd A. Aguilera, Ahmed M. Elamir, Rana Bahij, Martijn P. W. Intven, Ganesh Radhakrishna, Issa Mohamad, Jeremy De Leon, Hendrick Tan, Shirley Lewis, Cihan Gani, Teo Stanecu, Vero
    Current Oncology.2023; 30(10): 9230.     CrossRef
  • Evidence on percutaneous radiofrequency and microwave ablation for liver metastases over the last decade
    Koji Tomita, Yusuke Matsui, Mayu Uka, Noriyuki Umakoshi, Takahiro Kawabata, Kazuaki Munetomo, Shoma Nagata, Toshihiro Iguchi, Takao Hiraki
    Japanese Journal of Radiology.2022; 40(10): 1035.     CrossRef
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Erratum
ERRATUM: Prognostic Implications of Extranodal Extension in Relation to Colorectal Cancer Location
Chan Wook Kim, Jihun Kim, Yangsoon Park, Dong-Hyung Cho, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
Cancer Res Treat. 2021;53(3):893-893.   Published online June 8, 2021
DOI: https://doi.org/10.4143/crt.2018.392.E
Corrects: Cancer Res Treat 2019;51(3):1135
PDFPubReaderePub
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Original Articles
Association of Body Composition with Long-Term Survival in Non-metastatic Rectal Cancer Patients
Jin Soo Han, Hyoseon Ryu, In Ja Park, Kyung Won Kim, Yongbin Shin, Sun Ok Kim, Seok-Byung Lim, Chan Wook Kim, Yong Sik Yoon, Jong Lyul Lee, Chang Sik Yu, Jin Cheon Kim
Cancer Res Treat. 2020;52(2):563-572.   Published online December 3, 2019
DOI: https://doi.org/10.4143/crt.2019.249
AbstractAbstract PDFPubReaderePub
Purpose
We evaluated the association of body composition with long-term oncologic outcomes in non-metastatic rectal cancer patients.
Methods
We included 1,384 patients with stage(y)0-III rectal cancer treated at Asan Medical Center between January 2005 and December 2012. Body composition at diagnosis was measured using abdomino-pelvic computed tomography (CT). Sarcopenia, visceral obesity (VO), and sarcopenic obesity (SO) were defined using CT measured parameters such as skeletal muscle index (total abdominal muscle area, TAMA), visceral fat area (VFA), and VFA/TAMA. Inflammatory status was defined as a neutrophil-lymphocyte ratio of ≥3. Obesity was categorized by body mass index (≥ 25 kg/m2).
Results
Among the 1,384 patients, 944 (68.2%) had sarcopenia and 307 (22.2%) had SO. The 5-year overall survival (OS) rate was significantly lower in sarcopenic patients (no sarcopenia vs. sarcopenia; 84% vs. 78%, p=0.003) but the 5-year recurrence-free survival (RFS) rate was not different (77.3% vs. 77.9% p=0.957). Patients with SO showed lower 5-year OS (79.1% vs. 75.5% p=0.02) but no difference in 5-year RFS (p=0.957). Sarcopenia, SO, VO, and obesity were not associated with RFS. However, obesity, SO, age, sex, inflammatory status, and tumor stage were confirmed as independent factors associated with OS on multivariate analysis. In subgroup analysis, association of SO with OS was more prominent in patients with (y)p stage 0-2 and no inflammatory status.
Conclusion
The presence of SO and a low body mass index at diagnosis are negatively associated with OS in non-metastatic rectal cancer patients.

Citations

Citations to this article as recorded by  
  • Prognostic Impact of Sarcopenic Obesity on Postoperative Outcomes in Colorectal Cancer Patients Undergoing Surgery: A Systematic Review and Meta-Analysis
    Tuba Nur Yıldız Kopuz, Hanifi Furkan Yıldız, Sadettin Er, Mehmet Fisunoğlu
    Nutrition and Cancer.2025; 77(3): 360.     CrossRef
  • Effect of sarcopenic obesity on treatment results in patients with malignant tumors of the gastrointestinal tract: systematic review
    T. S. Boldyreva, V. K. Lyadov
    Supportive Therapy in Oncology.2025; 1(3): 26.     CrossRef
  • Impact of visceral obesity on postoperative outcomes in colorectal cancer: a systematic review and meta-analysis
    Yulong Wang, Xijuan Liu, Xiao Feng, Xing Jiang, Lili Huang
    Frontiers in Oncology.2025;[Epub]     CrossRef
  • Radiological Assessment of Sarcopenia and Its Clinical Impact in Patients with Hepatobiliary, Pancreatic, and Gastrointestinal Diseases: A Comprehensive Review
    Shameema Farook, Saumya Soni, Arpit Shantagiri, Pankaj Gupta, Anindita Sinha, Mahesh Prakash
    Journal of Gastrointestinal and Abdominal Radiology.2024; 07(01): 027.     CrossRef
  • Landscape and research trends of sarcopenic obesity research: A bibliometric analysis
    Huiyu Tang, Rongna Lian, Runjie Li, Jiaojiao Jiang, Ming Yang
    Heliyon.2024; 10(2): e24696.     CrossRef
  • Predictive role of preoperative sarcopenia for long-term survival in rectal cancer patients: A meta-analysis
    Qiutong Su, Jia Shen, Zubing Mei
    PLOS ONE.2024; 19(5): e0303494.     CrossRef
  • Sarcopenic obesity in cancer
    Mihaela Jurdana, Maja Cemazar
    Radiology and Oncology.2024; 58(1): 1.     CrossRef
  • Negative impact of sarcopenia on survival in elderly patients with colorectal cancer receiving surgery: A propensity‑score matched analysis
    Takeshi Nishikawa, Tetsuro Taira, Nao Kakizawa, Riki Ohno, Toshiya Nagasaki
    Oncology Letters.2024;[Epub]     CrossRef
  • Impact of body composition parameters on radiation therapy compliance in locally advanced rectal cancer: A retrospective observational analysis
    Giuditta Chiloiro, Marco Cintoni, Marta Palombaro, Angela Romano, Sara Reina, Gabriele Pulcini, Barbara Corvari, Silvia Di Franco, Elisa Meldolesi, Gabriele Egidi, Futura Grassi, Pauline Raoul, Emanuele Rinninella, Antonio Gasbarrini, Maria Cristina Mele,
    Clinical and Translational Radiation Oncology.2024; 47: 100789.     CrossRef
  • Post‐diagnosis adiposity and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis
    Nerea Becerra‐Tomás, Georgios Markozannes, Margarita Cariolou, Katia Balducci, Rita Vieira, Sonia Kiss, Dagfinn Aune, Darren C. Greenwood, Laure Dossus, Ellen Copson, Andrew G. Renehan, Martijn Bours, Wendy Demark‐Wahnefried, Melissa M. Hudson, Anne M. Ma
    International Journal of Cancer.2024; 155(3): 400.     CrossRef
  • Sarcopenia diagnosis in patients with colorectal cancer: a review of computed tomography-based assessments and emerging ways to enhance practicality
    Hye Jung Cho, Jeonghyun Kang
    Annals of Surgical Treatment and Research.2024; 106(6): 305.     CrossRef
  • Serum tumor marker and CT body composition scoring system predicts outcomes in colorectal cancer surgical patients
    Mingming Song, Zhihao Liu, Feihong Wu, Tong Nie, Yixin Heng, Jiaxin Xu, Ning Huang, Xiaoyu Wu, Yinghao Cao, Gang Hu
    European Radiology.2024; 34(12): 7596.     CrossRef
  • Computed tomography-measured body composition can predict long-term outcomes for stage I-III colorectal cancer patients
    Han Zhou, Lei Tian, Yiting Wu, Sibin Liu
    Frontiers in Oncology.2024;[Epub]     CrossRef
  • Prognostic significance of serum creatinine and sarcopenia for 5-year overall survival in patients with colorectal cancer in Korea: a comparative study
    Jiahn Choi, Hye Sun Lee, Jeonghyun Kang
    Annals of Clinical Nutrition and Metabolism.2024; 16(2): 66.     CrossRef
  • Age as a modifier of the effects of sarcopenia on survival among colon cancer patients after surgery
    Wen‐Li Lin, Li‐Min Wu, Wen‐Tsung Huang, How‐Ran Guo, Jyh‐Jou Chen
    Journal of Surgical Oncology.2023; 128(7): 1121.     CrossRef
  • Associations of muscle and adipose tissue parameters with long-term outcomes in middle and low rectal cancer: a retrospective cohort study
    Jiyang Liu, Xiongfeng Yu, Xueqing Huang, Qingquan Lai, Jieyun Chen
    Cancer Imaging.2023;[Epub]     CrossRef
  • Associations of Total Body Fat Mass and Skeletal Muscle Index with All-Cause and Cancer-Specific Mortality in Cancer Survivors
    Livingstone Aduse-Poku, Shama D. Karanth, Meghann Wheeler, Danting Yang, Caretia Washington, Young-Rock Hong, Todd M. Manini, Jesus C. Fabregas, Ting-Yuan David Cheng, Dejana Braithwaite
    Cancers.2023; 15(4): 1081.     CrossRef
  • Prognostic effect of sarcopenia in patients undergoing laparoscopic rectal cancer resection
    Giuseppe Portale, Matteo Zuin, Ylenia Camilla Spolverato, Patrizia Bartolotta, Dario Gregori, Carlo Rettore, Luca Cancian, Alberto Morabito, Teodoro Sava, Valentino Fiscon
    ANZ Journal of Surgery.2023; 93(6): 1631.     CrossRef
  • Nomogram for predicting the overall survival of underweight patients with colorectal cancer: a clinical study
    Jun Woo Bong, Younghyun Na, Yeonuk Ju, Chinock Cheong, Sanghee Kang, Sun Il Lee, Byung Wook Min
    BMC Gastroenterology.2023;[Epub]     CrossRef
  • Prognostic role of platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte, and lymphocyte-to-monocyte ratio in operated rectal cancer patients: systematic review and meta-analysis
    Giuseppe Portale, Patrizia Bartolotta, Danila Azzolina, Dario Gregori, Valentino Fiscon
    Langenbeck's Archives of Surgery.2023;[Epub]     CrossRef
  • The effects of muscle mass and quality on mortality of patients with acute kidney injury requiring continuous renal replacement therapy
    Jiyun Jung, Jangwook Lee, Jeong-Hoon Lim, Yong Chul Kim, Tae Hyun Ban, Woo Yeong Park, Kyeong Min Kim, Kipyo Kim, Sung Woo Lee, Sung Joon Shin, Seung Seok Han, Dong Ki Kim, Yousun Ko, Kyung Won Kim, Hyosang Kim, Jae Yoon Park
    Scientific Reports.2023;[Epub]     CrossRef
  • Sarcopenic Obesity Is a Risk Factor for Worse Oncological Long-Term Outcome in Locally Advanced Rectal Cancer Patients: A Retrospective Single-Center Cohort Study
    Peter Tschann, Markus P. Weigl, Patrick Clemens, Philipp Szeverinski, Christian Attenberger, Matthias Kowatsch, Tarkan Jäger, Klaus Emmanuel, Thomas Brock, Ingmar Königsrainer
    Nutrients.2023; 15(11): 2632.     CrossRef
  • Association between Computed Tomography-Determined Loss of Muscle Mass and Impaired Three-Month Survival in Frail Older Adults with Cancer
    Antti Tolonen, Hanna Kerminen, Kaisa Lehtomäki, Heini Huhtala, Maarit Bärlund, Pia Österlund, Otso Arponen
    Cancers.2023; 15(13): 3398.     CrossRef
  • Diagnosis and prevalence of sarcopenic obesity in patients with colorectal cancer: A scoping review
    Yoko Saino, Fumiya Kawase, Ayano Nagano, Junko Ueshima, Haruko Kobayashi, Kenta Murotani, Tatsuro Inoue, Shinsuke Nagami, Mizue Suzuki, Keisuke Maeda
    Clinical Nutrition.2023; 42(9): 1595.     CrossRef
  • Sarcopenia as a prognostic indicator in colorectal cancer: an updated meta-analysis
    Jie He, Wei Luo, Yuanyuan Huang, Lingmeng Song, Yang Mei
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Sarcopenia, Precardial Adipose Tissue and High Tumor Volume as Outcome Predictors in Surgically Treated Pleural Mesothelioma
    Oliver Guido Verhoek, Lisa Jungblut, Olivia Lauk, Christian Blüthgen, Isabelle Opitz, Thomas Frauenfelder, Katharina Martini
    Diagnostics.2022; 12(1): 99.     CrossRef
  • Skeletal muscle wasting and long-term prognosis in patients undergoing rectal cancer surgery without neoadjuvant therapy
    Alessandro Giani, Simone Famularo, Alessandro Fogliati, Luca Riva, Nicolò Tamini, Davide Ippolito, Luca Nespoli, Marco Braga, Luca Gianotti
    World Journal of Surgical Oncology.2022;[Epub]     CrossRef
  • Value-added Opportunistic CT Screening: State of the Art
    Perry J. Pickhardt
    Radiology.2022; 303(2): 241.     CrossRef
  • Sarcopenic obesity: What about in the cancer setting?
    Gianluca Gortan Cappellari, Caterina Brasacchio, Daniela Laudisio, Carla Lubrano, Francesca Pivari, Luigi Barrea, Giovanna Muscogiuri, Silvia Savastano, Annamaria Colao
    Nutrition.2022; 98: 111624.     CrossRef
  • CT-Derived Body Composition Assessment as a Prognostic Tool in Oncologic Patients: From Opportunistic Research to Artificial Intelligence–Based Clinical Implementation
    David D. B. Bates, Perry J. Pickhardt
    American Journal of Roentgenology.2022; 219(4): 671.     CrossRef
  • Prevalence and prognostic value of sarcopenic obesity in patients with cancer: A systematic review and meta-analysis
    Qianqian Gao, Kaiyan Hu, Jing Gao, Yi Shang, Fan Mei, Li Zhao, Fei Chen, Bin Ma
    Nutrition.2022; 101: 111704.     CrossRef
  • Prognostic value of sarcopenia in patients with rectal cancer: A meta-analysis
    Yueli Zhu, Xiaoming Guo, Qin Zhang, Yunmei Yang, Zubing Mei
    PLOS ONE.2022; 17(6): e0270332.     CrossRef
  • A systematic review and meta-analysis assessing the impact of body mass index on long-term survival outcomes after surgery for colorectal cancer
    Constantinos Simillis, Beth Taylor, Ayesha Ahmad, Nikhil Lal, Thalia Afxentiou, Michael P. Powar, Elizabeth C. Smyth, Nicola S. Fearnhead, James Wheeler, Richard J. Davies
    European Journal of Cancer.2022; 172: 237.     CrossRef
  • Sarcobesity Index Predicts Poor Disease-Specific Survival After Resection for Colorectal Cancer
    Cristian Conti, Giulia Turri, Gabriele Gecchele, Simone Conci, Giulia A. Zamboni, Andrea Ruzzenente, Alfredo Guglielmi, Corrado Pedrazzani
    Journal of Surgical Research.2022; 279: 398.     CrossRef
  • Sarcopenic obesity and therapeutic outcomes in gastrointestinal surgical oncology: A meta-analysis
    Peiyu Wang, Shaodong Wang, Yi Ma, Haoran Li, Zheng Liu, Guihu Lin, Xiao Li, Fan Yang, Mantang Qiu
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Adiposity and cancer survival: a systematic review and meta-analysis
    En Cheng, Jocelyn Kirley, Elizabeth M. Cespedes Feliciano, Bette J. Caan
    Cancer Causes & Control.2022; 33(10): 1219.     CrossRef
  • Obesity may not be related to pathologic response in locally advanced rectal cancer following neoadjuvant chemoradiotherapy
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  • Lifestyle interventions after colorectal cancer surgery using a mobile digital device: A study protocol for a randomized controlled trial
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  • Serial Changes in Body Composition and the Association with Disease Activity during Treatment in Patients with Crohn’s Disease
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  • Sarcopenia as a Prognostic Marker in Elderly Head and Neck Squamous Cell Carcinoma Patients Undergoing (Chemo-)Radiation
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    Cancers.2022; 14(22): 5536.     CrossRef
  • Marked loss of adipose tissue during neoadjuvant therapy as a predictor for poor prognosis in patients with gastric cancer: A retrospective cohort study
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    Journal of Human Nutrition and Dietetics.2021; 34(3): 585.     CrossRef
  • Sarcopenia predicts worse postoperative outcomes and decreased survival rates in patients with colorectal cancer: a systematic review and meta-analysis
    Mario Trejo-Avila, Katya Bozada-Gutiérrez, Carlos Valenzuela-Salazar, Jesús Herrera-Esquivel, Mucio Moreno-Portillo
    International Journal of Colorectal Disease.2021; 36(6): 1077.     CrossRef
  • Prognostic and predictive value of neutrophil-to-lymphocyte ratio after curative rectal cancer resection: A systematic review and meta-analysis
    Hytham K.S. Hamid, George N. Davis, Mario Trejo-Avila, Patrick O. Igwe, Andrés Garcia-Marín
    Surgical Oncology.2021; 37: 101556.     CrossRef
  • The Role of Sarcopenic Obesity in Cancer and Cardiovascular Disease: A Synthesis of the Evidence on Pathophysiological Aspects and Clinical Implications
    Erika Aparecida Silveira, Rômulo Roosevelt da Silva Filho, Maria Claudia Bernardes Spexoto, Fahimeh Haghighatdoost, Nizal Sarrafzadegan, Cesar de Oliveira
    International Journal of Molecular Sciences.2021; 22(9): 4339.     CrossRef
  • Influence of Postoperative Changes in Sarcopenia on Long-Term Survival in Non-Metastatic Colorectal Cancer Patients
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    Cancers.2021; 13(10): 2410.     CrossRef
  • Preoperative computed tomography-assessed sarcopenia as a predictor of complications and long-term prognosis in patients with colorectal cancer: a systematic review and meta-analysis
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  • Sarcopenia Is Associated With Hematologic Toxicity During Chemoradiotherapy in Patients With Anal Carcinoma
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Prognostic Implications of Extranodal Extension in Relation to Colorectal Cancer Location
Chan Wook Kim, Jihun Kim, Yangsoon Park, Dong-Hyung Cho, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
Cancer Res Treat. 2019;51(3):1135-1143.   Published online November 29, 2018
DOI: https://doi.org/10.4143/crt.2018.392
Correction in: Cancer Res Treat 2021;53(3):893
AbstractAbstract PDFPubReaderePub
Purpose
Extranodal extension (ENE) is closely associated with the aggressiveness of both colon and rectal cancer. This study evaluated the clinicopathologic significance and prognostic impact of ENE in separate populations of patients with colon and rectal cancers.
Materials and Methods
The medical records of 2,346 patients with colorectal cancer (CRC) who underwent curative surgery at our institution between January 2003 and December 2011 were clinically and histologically reviewed.
Results
ENE was associated with younger age, advanced tumor stage, lymphovascular invasion (LVI), and perineural invasion (PNI) in both colon and rectal cancer. ENE rates differed significantly in patients with right colon (36.9%), left colon (42.6%), and rectal (48.7%) cancers (right vs. left, p=0.037; left vs. rectum, p=0.009). The 5-year disease-free survival (DFS) rate according to ENE status and primary tumor site differed significantly in patients with ENE-negative colon cancer (80.5%), ENE-negative rectal cancer (77.4%), ENE-positive colon cancer (68.6%), and ENE-positive rectal cancer (64.2%) (p<0.001). Multivariate analysis showed that advanced tumor stage, ENE, LVI, PNI, and absence of adjuvant chemotherapy were independently prognostic of reduced DFS in colon and rectal cancer patients.
Conclusion
ENE is closely associated with the aggressiveness of colon and rectal cancers, with its frequency increasing from the right colon to the left colon to the rectum. ENE status is a significant independent predictor of DFS in CRC patients irrespective of tumor location. ENE might be more related with distally located CRC.

Citations

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  • Tumour deposits are associated with worse survival than extranodal extension; a network meta‐analysis on tumour nodules in colorectal cancer
    Nelleke P M Brouwer, Shannon van Vliet, Joanna IntHout, Johannes H W De Wilt, Femke Simmer, Niek Hugen, Iris D Nagtegaal
    Histopathology.2025; 86(4): 485.     CrossRef
  • Assessment of prognostic indicators and KRAS mutations in rectal cancer using a fractional-order calculus MR diffusion model: whole tumor histogram analysis
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  • Prediction of Postoperative Survival Nomogram of Colorectal Cancer Patients based on Lymph Node Classification: a Study based on a SEER Population
    Xuefei Zhang, Lanxin Hu, Junfeng Du, Chen Su, Xiang Xu
    Journal of Contemporary Medical Practice.2024; 6(12): 188.     CrossRef
  • MRI-based multiregional radiomics for predicting lymph nodes status and prognosis in patients with resectable rectal cancer
    Hang Li, Xiao-li Chen, Huan Liu, Tao Lu, Zhen-lin Li
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Prognostic significance of extranodal extension of nodal metastasis in adenocarcinoma of the ampulla of Vater
    Jihyun Chun, Yeon Wook Kim, Seo-rin Jeong, Hyung Jun Cho, Kyu-Pyo Kim, Dae Wook Hwang, Seung-Mo Hong
    Human Pathology.2023; 137: 36.     CrossRef
  • Dissimilar survival and clinicopathological characteristics of mucinous adenocarcinoma located in pancreatic head and body/tail
    Zheng Li, Xiao-Jie Zhang, Chong-Yuan Sun, Ze-Feng Li, He Fei, Dong-Bing Zhao
    World Journal of Gastrointestinal Surgery.2023; 15(6): 1178.     CrossRef
  • Effect of visceral fat area on the accuracy of preoperative CT-N staging of colorectal cancer
    Meizhen Xie, Gangyi Liu, Yan Dong, Lan Yu, Rui Song, Wei Zhang, Ying Zhang, Shafei Huang, Jiaqian He, Yunping Xiao, Liling Long
    European Journal of Radiology.2023; 168: 111131.     CrossRef
  • Prognostic Value of the N1c in Stage III and IV Colorectal Cancer: A Propensity Score Matching Study Based on the Surveillance, Epidemiology, and End Results (SEER) Database
    Chongshun Liu, Mengxiang Tian, Haiping Pei, Fengbo Tan, Yuqiang Li
    Journal of Investigative Surgery.2022; 35(4): 850.     CrossRef
  • Tumor Deposits and Perineural Invasion had Comparable Impacts on the Survival of Patients With Non-metastatic Colorectal Adenocarcinoma: A Population-Based Propensity Score Matching and Competing Risk Analysis
    Bin Luo, Xianzhe Chen, Guanfu Cai, Weixian Hu, Yong Li, Junjiang Wang
    Cancer Control.2022;[Epub]     CrossRef
  • The application of apparent diffusion coefficients derived from intratumoral and peritumoral zones for assessing pathologic prognostic factors in rectal cancer
    Yi Yuan, Xiao-li Chen, Zhen-lin Li, Guang-wen Chen, Hao Liu, Yi-Sha Liu, Ming-hui Pang, Si-yun Liu, Hong Pu, Hang Li
    European Radiology.2022; 32(8): 5106.     CrossRef
  • Beyond N staging in colorectal cancer: Current approaches and future perspectives
    Gianluca Arrichiello, Mario Pirozzi, Bianca Arianna Facchini, Sergio Facchini, Fernando Paragliola, Valeria Nacca, Antonella Nicastro, Maria Anna Canciello, Adele Orlando, Marianna Caterino, Davide Ciardiello, Carminia Maria Della Corte, Morena Fasano, St
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Clinical Implication of Perineural and Lymphovascular Invasion in Rectal Cancer Patients Who Underwent Surgery After Preoperative Chemoradiotherapy
    Young Il Kim, Chan Wook Kim, Jong Hoon Kim, Jihun Kim, Jun-Soo Ro, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
    Diseases of the Colon & Rectum.2022; 65(11): 1325.     CrossRef
  • Prognostic Impact of Extranodal Extension in Rectal Cancer Patients Undergoing Radical Resection After Preoperative Chemoradiotherapy
    Young Il Kim, Haeyon Cho, Chan Wook Kim, Yangsoon Park, Jihun Kim, Jun-Soo Ro, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
    Clinical Colorectal Cancer.2021; 20(1): e35.     CrossRef
  • Analysis of the Clinicopathological Characteristics of Stage I–III Colorectal Cancer Patients Deficient in Mismatch Repair Proteins
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    OncoTargets and Therapy.2021; Volume 14: 2203.     CrossRef
  • Clinical significance of extranodal extension in sentinel lymph node positive breast cancer
    Xia Yang, XiaoXi Ma, Wentao Yang, Ruohong Shui
    Scientific Reports.2020;[Epub]     CrossRef
  • 9,041 View
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  • 17 Web of Science
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Paired Primary and Metastatic Tumor Analysis of Somatic Mutations in Synchronous and Metachronous Colorectal Cancer
Kyu-pyo Kim, Jeong-Eun Kim, Yong Sang Hong, Sung-Min Ahn, Sung Min Chun, Seung-Mo Hong, Se Jin Jang, Chang Sik Yu, Jin Cheon Kim, Tae Won Kim
Cancer Res Treat. 2017;49(1):161-167.   Published online July 4, 2016
DOI: https://doi.org/10.4143/crt.2015.490
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Although the mutation status of KRAS is highly concordant in primary and metastatic lesions, it has not been generalized to other major pathway genes.
Materials and Methods
In this study, 41 genes were evaluated and the mutational profiles were compared in 46 colorectal cancer patients with paired surgical specimens of primary and metastatic lesions: synchronous (n=27) and metachronous (n=19) lesions. A high-throughput mass spectrometry-based genotyping platform validated by orthogonal chemistry, OncoMap v.4.4, was used to evaluate the formalin-fixed, paraffin-embedded surgical specimens. The patients’ demographics, tumor characteristics, and microsatellite instability status were analyzed by a retrospective chart review.
Results
In this study,with OncoMap, mutationswere identified in 80.4% of patientswith the following frequency: KRAS (39.1%), TP53 (28.3%), APC (28.3%), PIK3CA (6.5%), BRAF (6.5%), and NRAS (4.3%). Although 19.6% (9/46) of the patients showed no gene mutations, 43.5% (20/46) and 37.0% (17/46) had mutations in one and two or more genes, respectively. The synchronous and metachronous lesions showed similar mutational profiles. Paired samples between primary and metastatic tumors differed in 7.4% (2/27) and 10.5% (2/19) for synchronous and metachronous according to OncoMap.
Conclusion
These findings indicate the major pathway genes, including KRAS, TP53, APC, PIK3CA, BRAF, and NRAS, are often concordant between the primary and metastatic lesions regardless of the temporal relationship of metastasis.

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  • Analysis of Shared Variants between Cancer Biospecimens
    Michael B. Foote, James Robert White, Walid K. Chatila, Guillem Argilés, Steve Lu, Benoit Rousseau, Oliver Artz, Paul Johannet, Henry Walch, Mitesh Patel, Michelle F. Lamendola-Essel, David Casadevall, Somer Abdelfattah, Shrey Patel, Rona Yaeger, Andrea C
    Clinical Cancer Research.2025; 31(2): 376.     CrossRef
  • Mutation characteristics and molecular evolution of ovarian metastasis from gastric cancer and potential biomarkers for paclitaxel treatment
    Pengfei Yu, Can Hu, Guangyu Ding, Xiaoliang Shi, Jingli Xu, Yang Cao, Xiangliu Chen, Wei Wu, Qi Xu, Jingquan Fang, Xingmao Huang, Shaohua Yuan, Hui Chen, Zhizheng Wang, Ling Huang, Fei Pang, Yian Du, Xiangdong Cheng
    Nature Communications.2024;[Epub]     CrossRef
  • The varied clonal trajectory of liver and lung metastases of colorectal cancer
    Ofer N. Gofrit, Ben Gofrit, S. Nahum Goldberg, Aron Popovtzer, Jacob Sosna, Ayala Hubert
    Advances in Cancer Biology - Metastasis.2024; 11: 100122.     CrossRef
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    Jaspreet Kaur, Darshan S. Chandrashekar, Zsuzsanna Varga, Bettina Sobottka, Emiel Janssen, Khanjan Gandhi, Jeanne Kowalski, Umay Kiraz, Sooryanarayana Varambally, Ritu Aneja
    Genes.2023; 14(9): 1690.     CrossRef
  • The different clonal origins of metachronous and synchronous metastases
    Ofer N. Gofrit, Ben Gofrit, Yuval Roditi, Aron Popovtzer, Steve Frank, Jacob Sosna, Marina Orevi, S. Nahum Goldberg
    Journal of Cancer Research and Clinical Oncology.2023; 149(13): 11085.     CrossRef
  • Inoperable de novo metastatic colorectal cancer with primary tumour in situ: Evaluating discordant responses to upfront systemic therapy of the primary tumours and metastatic sites and complications arising from primary tumours (experiences from an Irish
    Ruba Hamed, Sam Marks, Helen Mcelligott, Roshni Kalachand, Hawa Ibrahim, Said Atyani, Greg Korpanty, Nemer Osman
    Molecular and Clinical Oncology.2021;[Epub]     CrossRef
  • Association of DNA repair gene polymorphisms with colorectal cancer risk and treatment outcomes
    Fawaz N. Al-Shaheri, Kamal M. Al-Shami, Eshrak H. Gamal, Amjad A. Mahasneh, Nehad M. Ayoub
    Experimental and Molecular Pathology.2020; 113: 104364.     CrossRef
  • High Concordance and Negative Prognostic Impact of RAS/BRAF/PIK3CA Mutations in Multiple Resected Colorectal Liver Metastases
    Tuva Høst Brunsell, Anita Sveen, Bjørn Atle Bjørnbeth, Bård I. Røsok, Stine Aske Danielsen, Kristoffer Watten Brudvik, Kaja C.G. Berg, Bjarne Johannessen, Vanja Cengija, Andreas Abildgaard, Marianne Grønlie Guren, Arild Nesbakken, Ragnhild A. Lothe
    Clinical Colorectal Cancer.2020; 19(1): e26.     CrossRef
  • Case report: recurrent pituitary adenoma has increased load of somatic variants
    Raitis Peculis, Inga Balcere, Ilze Radovica-Spalvina, Ilze Konrade, Olivija Caune, Kaspars Megnis, Vita Rovite, Janis Stukens, Jurijs Nazarovs, Austra Breiksa, Aigars Kiecis, Ivars Silamikelis, Valdis Pirags, Janis Klovins
    BMC Endocrine Disorders.2020;[Epub]     CrossRef
  • Transcriptomic analysis by RNA sequencing characterises malignant progression of canine insulinoma from normal tissue to metastatic disease
    Y. Capodanno, F. O. Buishand, L. Y. Pang, J. Kirpensteijn, J. A. Mol, R. Elders, D. J. Argyle
    Scientific Reports.2020;[Epub]     CrossRef
  • Genetic Alterations of Metastatic Colorectal Cancer
    Ugo Testa, Germana Castelli, Elvira Pelosi
    Biomedicines.2020; 8(10): 414.     CrossRef
  • Prognostic impact of the Fusobacterium nucleatum status in colorectal cancers
    Yanglong Chen, Ying Lu, Yuting Ke, Yanling Li
    Medicine.2019; 98(39): e17221.     CrossRef
  • Microsatellite Instability: Diagnosis, Heterogeneity, Discordance, and Clinical Impact in Colorectal Cancer
    Camille Evrard, Gaëlle Tachon, Violaine Randrian, Lucie Karayan-Tapon, David Tougeron
    Cancers.2019; 11(10): 1567.     CrossRef
  • Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: implications for therapeutic targeting
    William Hankey, Wendy L. Frankel, Joanna Groden
    Cancer and Metastasis Reviews.2018; 37(1): 159.     CrossRef
  • Colorectal Cancer: Genetic Abnormalities, Tumor Progression, Tumor Heterogeneity, Clonal Evolution and Tumor-Initiating Cells
    Ugo Testa, Elvira Pelosi, Germana Castelli
    Medical Sciences.2018; 6(2): 31.     CrossRef
  • Comparison of genetic profiles among primary lung tumor, metastatic lymph nodes and circulating tumor DNA in treatment-naïve advanced non-squamous non-small cell lung cancer patients
    Fangfang Xie, Yujun Zhang, Xiaowei Mao, Xiaoxuan Zheng, Han Han-Zhang, Junyi Ye, Ruiying Zhao, Xueyan Zhang, Jiayuan Sun
    Lung Cancer.2018; 121: 54.     CrossRef
  • Association of BRAF Mutations With Survival and Recurrence in Surgically Treated Patients With Metastatic Colorectal Liver Cancer
    Georgios Antonios Margonis, Stefan Buettner, Nikolaos Andreatos, Yuhree Kim, Doris Wagner, Kazunari Sasaki, Andrea Beer, Christoph Schwarz, Inger Marie Løes, Maria Smolle, Carsten Kamphues, Jin He, Timothy M. Pawlik, Klaus Kaczirek, George Poultsides, Per
    JAMA Surgery.2018; 153(7): e180996.     CrossRef
  • Heterogeneity in Colorectal Cancer: A Challenge for Personalized Medicine?
    Chiara Molinari, Giorgia Marisi, Alessandro Passardi, Laura Matteucci, Giulia De Maio, Paola Ulivi
    International Journal of Molecular Sciences.2018; 19(12): 3733.     CrossRef
  • 10,876 View
  • 279 Download
  • 21 Web of Science
  • 18 Crossref
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Preliminary Suggestion about Staging of Anorectal Malignant Melanoma May Be Used to Predict Prognosis
Won Young Chae, Jong Lyul Lee, Dong-Hyung Cho, Chang Sik Yu, Jin Roh, Jin Cheon Kim
Cancer Res Treat. 2016;48(1):240-249.   Published online March 6, 2015
DOI: https://doi.org/10.4143/crt.2014.305
AbstractAbstract PDFPubReaderePub
Purpose
Anorectal malignant melanomas (AMM) are rare and have poor survival. The study aims to evaluate the clinicopathologic characteristics and outcomes of patients with AMM, and to devise a staging system predictive of survival outcome.
Materials and Methods
This was a retrospective study of 28 patients diagnosed with, and treated for AMM. Patients classified by clinical staging of mucosal melanoma (MM) were reclassified via rectal and anal TNM staging. Survival outcomes were compared among patients grouped by the three different staging systems.
Results
The three staging systems were equated with similar figures for 5-year overall survival (OS) and 5-year disease-free survival (DFS) of patients diagnosed with stage I disease. Patients (n=19) diagnosed with MM stage II disease were reclassified by rectal TNM staging into three subgroups: IIIA, IIIB, and IIIC. For these patients, both 5-year OS and 5-year DFS differed significantly between the subgroups IIIA and IIIC (OS: IIIA vs. IIIC, 66.7% vs. 0%, p=0.002; DFS: IIIA vs. IIIC, 51.4% vs. 0%, p < 0.001).
Conclusion
The accuracy of prognosis in patients diagnosed with AMM and lymph node metastasis has improved by using rectal TNM staging, which includes information regarding the number of lymph node metastases.

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  • Survival and Prognosis for Patients with Rectal Melanomas in the United States: A SEER-Based Study
    Fan Zhang, Boqi Xu, Yao Peng, Runda Wu, Shan Tong, Zhongqi Mao
    Journal of Investigative Surgery.2024;[Epub]     CrossRef
  • Incidence and survival of patients with primary gastrointestinal melanoma: a population-based study
    Yu Du, Xiaona Chang, Xiangxiang Li, Shugang Xing
    International Journal of Colorectal Disease.2023;[Epub]     CrossRef
  • Melanoma anorrectal primario: reporte de un caso y revisión de una neoplasia infrecuente
    Hernando Marulanda Fernández, Felipe Vera-Polanía, Juan Antonio Trejos Naranjo, Julian Ernesto Parga Bermudez, William Otero Regino
    Revista colombiana de Gastroenterología.2023; 38(4): 504.     CrossRef
  • A New Anorectal Melanoma Cell Line Derived from a Primary Human Rectal Tumor
    Seiichi Shinji, Yuuki Shichi, Takeshi Yamada, Goro Takahashi, Ryo Ohta, Hiromichi Sonoda, Akihisa Matsuda, Kazuhide Yonaga, Takuma Iwai, Kohki Takeda, Koji Ueda, Sho Kuriyama, Toshimitsu Miyasaka, Yoshibumi Ueda, Norihiko Sasaki, Kimimasa Takahashi, Ryuji
    Journal of Nippon Medical School.2022; 89(4): 368.     CrossRef
  • Difficulties in diagnosing anorectal melanoma: A case report and review of the literature
    Raluca Cristina Apostu, Elena Stefanescu, Radu Razvan Scurtu, Gabriel Kacso, Radu Drasovean
    World Journal of Clinical Cases.2021; 9(36): 11369.     CrossRef
  • Outcomes of Surgical Treatment for Patients with Anorectal Malignant Melanoma; Results of Nine Cases in a Single Institution
    Tomoyuki Nagaoka, Toshiya Nagasaki, Takashi Akiyoshi, Toshiki Mukai, Tomohiro Yamaguchi, Eiji Shinozaki, Yosuke Fukunaga
    Journal of the Anus, Rectum and Colon.2021; 5(2): 192.     CrossRef
  • Management and outcomes of primary anorectal melanoma in the United States
    Hari Menon, Roshal R Patel, Taylor R Cushman, Arya Amini, Steven N Seyedin, Anngela C Adams, Chi Lin, Vivek Verma
    Future Oncology.2020; 16(8): 329.     CrossRef
  • Melanoma anal, una patología radicalmente distinta al melanoma cutáneo, con un pronóstico infausto
    Mireia Merichal Resina, Carlos Cerdan Santacruz, Enrique Sierra Grañón, Jordi Antoni Tarragona Foradada, Jorge Juan Olsina Kissler
    Cirugía Española.2020; 98(8): 491.     CrossRef
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    Mireia Merichal Resina, Carlos Cerdan Santacruz, Enrique Sierra Grañón, Jordi Antoni Tarragona Foradada, Jorge Juan Olsina Kissler
    Cirugía Española (English Edition).2020; 98(8): 491.     CrossRef
  • Beyond adenocarcinoma: MRI of uncommon rectal neoplasms and mimickers
    David D. B. Bates, Maria Clara Fernandes de Paula, Natally Horvat, Shannon Sheedy, Chandana Lall, Zahra Kassam, Perry Pickhardt, Neeraj Lalwani, Dhakshinamoorthy Ganeshan, Iva Petkovska
    Abdominal Radiology.2019; 44(11): 3581.     CrossRef
  • Prognostic factors in primary anorectal melanoma: a clinicopathological study of 60 cases in China
    Min Ren, Yawen Lu, Jiaojie Lv, Xuxia Shen, Jincheng Kong, Bo Dai, Yunyi Kong
    Human Pathology.2018; 79: 77.     CrossRef
  • 16,294 View
  • 191 Download
  • 10 Web of Science
  • 11 Crossref
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Correspondence
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Original Articles
Clinical Characteristics and Adequate Treatment of Familial Adenomatous Polyposis Combined with Desmoid Tumors
Won Beom Jung, Chan Wook Kim, Jin Cheon Kim
Cancer Res Treat. 2014;46(4):366-373.   Published online August 25, 2014
DOI: https://doi.org/10.4143/crt.2013.185
AbstractAbstract PDFPubReaderePub
Purpose
The objective of this study was to examine the clincopathologic characteristics and outcomes of familial adenomatous polyposis (FAP) patients with and without desmoid tumors (DTs), including the risk factors for progression of FAP-related DTs. Materials and Methods We reviewed the medical records and database of all patients with FAP who were treated between January 1993 and December 2011. Results Of 75 FAP patients, 18 (24%) were FAP with DTs. Seventeen of these had intra-abdominal DTs and one had intra- and extra-abdominal DTs. We divided the patients into two groups according to type of resection; the R0 or R1 resection group, referred to as the curative resection group (eight patients), and the R2 resection/palliative operation/medical treatment group, referred to as the palliative resection group (10 patients). Two patients in the curative resection group and two patients in the palliative group had progressed to tumor growth by the follow-up (p=0.800). In univariate analysis, DT diagnosis before or simultaneously with FAP diagnosis (DTs unrelated to surgical trauma) was a significant risk factor for tumor progression at final follow-up. Conclusion A multidisciplinary approach to DT treatment is needed, including nonsteroidal antiinflammatory drugs, anti-estrogens, cytotoxic agents, and surgery. However, the role of surgery in resectable and complicated tumors may be limited. DT unrelated to surgical trauma has a relatively poor prognosis.

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  • The language of palliative surgery: A scoping review
    K.E. Kopecky, O. Monton, C. Arbaugh, J. Purchla, L. Rosman, S. Seal, F.M. Johnston
    Surgical Oncology Insight.2024; 1(2): 100053.     CrossRef
  • Adenomatous Polyposis Coli Gene Mutations, Risk Factors, and Long-term Outcomes Associated With Desmoid Tumors in Patients With Familial Adenomatous Polyposis After Colectomy in Japan
    Tadahiro Kojima, Kiyotaka Kurachi, Moriya Iwaizumi, Kyota Tatsuta, Kosuke Sugiyama, Toshiya Akai, Mayu Sakata, Yoshifumi Morita, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Hiroya Takeuchi
    Journal of Clinical Gastroenterology.2024;[Epub]     CrossRef
  • Giant desmoid tumour mimicking recurrent uterine myoma in a nulliparous young Nigerian: a case report
    Obinna Chukwunwike Njoku, Chisara Cyprian Umezurike
    Journal of Medical Case Reports.2022;[Epub]     CrossRef
  • Entirely Robot-assisted Total Colectomy/Total Proctocolectomy Compared With a Laparoscopic Approach
    Jin Cheon Kim, Jong Lyul Lee, Yong Sik Yoon, Hyung Min Kim, Chan Wook Kim, In Ja Park, Abdulmohsin Fawzi Aldilaijan, Seok-Byung Lim
    Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2021; 31(4): 428.     CrossRef
  • Caring for a patient with a desmoid tumor
    Janette O'Sullivan, Margaret Vanderbeek-Warren
    Nursing.2018; 48(6): 27.     CrossRef
  • Genetic profile, risk factors and therapeutic approach of desmoid tumors in familial adenomatous polyposis
    Ana Catarina Ribeiro Freitas, Laura Elisabete Ribeiro Barbosa
    Journal of Coloproctology.2017; 37(02): 163.     CrossRef
  • Tumeurs desmoïdes dans le cadre d’une polypose adénomateuse familiale chez une adolescente
    M. Creuzé, P. Afchain, A. Munck, J. Viala, A. Bonnard, V. Bertrand
    Archives de Pédiatrie.2016; 23(11): 1141.     CrossRef
  • Clinicopathological features of familial adenomatous polyposis in Korean patients
    Sung Min Jung, Yong Sik Yoon, Seok-Byeong Lim, Chang Sik Yu, Jin Cheon Kim
    World Journal of Gastroenterology.2016; 22(17): 4380.     CrossRef
  • Commentary on “Clinical Characteristics and Adequate Treatment of Familial Adenomatous Polyposis Combined with Desmoid Tumors”
    Edoardo Virgilio, Francesca Di Gregorio, Genoveffa Balducci
    Cancer Research and Treatment.2015; 47(2): 339.     CrossRef
  • Reply to Commentary on “Clinical Characteristics and Adequate Treatment of Familial Adenomatous Polyposis Combined with Desmoid Tumors”
    Jin Cheon Kim
    Cancer Research and Treatment.2015; 47(2): 341.     CrossRef
  • Optimal therapy for desmoid tumors: current options and challenges for the future
    Mushriq Al-Jazrawe, Magdalene Au, Benjamin Alman
    Expert Review of Anticancer Therapy.2015; 15(12): 1443.     CrossRef
  • 13,120 View
  • 79 Download
  • 9 Web of Science
  • 11 Crossref
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Clinicopathologic Characteristics, Surgical Treatment and Outcomes for Splenic Flexure Colon Cancer
Chan Wook Kim, Ui Sup Shin, Chang Sik Yu, Jin Cheon Kim
Cancer Res Treat. 2010;42(2):69-76.   Published online June 30, 2010
DOI: https://doi.org/10.4143/crt.2010.42.2.69
AbstractAbstract PDFPubReaderePub
Purpose

This current study examined the clinicopathologic characteristics of patients with splenic flexure (SF) colon cancer and the association with the surgical outcomes to find the optimal procedure to treat this malady.

Materials and Methods

A total of 167 operated patients with SF colon cancer were consecutively recruited between 1993 and 2003. The clinicopathological, operative and survival data was reviewed and analyzed.

Results

For the SF colon cancer patients, the proportion of males was higher than that for the right-sided colon patients or the sigmoid-descending junction & sigmoid (SD & S) colon patients (p≤0.05, respectively) and the age at the time of diagnosis was younger (p≤0.05). Obstruction was more frequent in the patients with SF colon cancer than that for the patients with colon cancer at other sites (p≤0.001). The incidence of mucinous adenocarcinoma for the SF patients was similar to that for the patients with right-sided colon cancer, but it was higher than that for the patients with SD & S colon cancer (11.4% vs. 6.5%, p=0.248 or 2.5%, respectively, p=0.001). Disease-free and overall survival did not differ between the patients who underwent a left hemicolectomy and extended surgery such as combined splenectomy or subtotal colectomy. Multivariate analysis showed that old age (≥60 years) and a N1-2 and M1 status were the independent risk factors for overall survival.

Conclusion

The SF colon cancers exhibited exclusively different characteristics as compared to colon cancers at other site colon cancers. It appears that left hemicolectomy was generally sufficient for a satisfactory oncological outcome, obviating concurrent splenectomy.

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  • Surgical approach to splenic flexure adenocarcinoma of the colon: Less is more?
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    Surgical Oncology Insight.2024; 1(2): 100039.     CrossRef
  • Laparoscopic extended right colectomy with complete mesocolic excision and en bloc splenectomy for a distal transverse colon cancer—A video vignette
    Javier Vela, Christophe Riquoir, Juan Alvarado, Nicolás Besser, José Tomás Larach
    Colorectal Disease.2024; 26(7): 1485.     CrossRef
  • Extended procedure has no oncological benefits over segmental resection in the treatment of non-metastatic splenic flexure colon cancer, a population-based cohort study and a single center’s decade-long experience
    Xiaojie Wang, Yangyang Wang, Zhifang Zheng, Zhiping Chen, Zhongdong Xie, Xingrong Lu, Shenghui Huang, Ying Huang, Pan Chi
    Updates in Surgery.2024; 76(4): 1289.     CrossRef
  • Splenic flexure adenocarcinoma: A national cohort analysis of extent of surgical resection and outcomes
    Julia F. Kohn, Sonja Boatman, Qi Wang, Schelomo Marmor, Imran Hassan, Robert D. Madoff, Wolfgang B. Gaertner, Paolo Goffredo
    Colorectal Disease.2024; 26(11): 1883.     CrossRef
  • Minimally invasive vs. open segmental resection of the splenic flexure for cancer: a nationwide study of the Italian Society of Surgical Oncology-Colorectal Cancer Network (SICO-CNN)
    Maurizio Degiuli, Monica Ortenzi, Mariano Tomatis, Lucia Puca, Desiree Cianflocca, Daniela Rega, Annalisa Maroli, Ugo Elmore, Francesca Pecchini, Marco Milone, Roberta La Mendola, Erica Soligo, Simona Deidda, Domenico Spoletini, Diletta Cassini, Alessandr
    Surgical Endoscopy.2023; 37(2): 977.     CrossRef
  • Short and long-term oncologic outcomes of patients with colon cancer of the splenic flexure
    Chi Zhang, Esteban Calderon, Yu Hui Chang, Ga-ram Han, Scott R. Kelley, Amit Merchea, Justin T. Brady, Tonia M. Young-Fadok, David A. Etzioni, Nitin Mishra
    The American Journal of Surgery.2023; 226(1): 77.     CrossRef
  • Splenic flexure cancer survival: a 25‐year experience and implications for complete mesocolic excision (CME) and central vascular ligation (CVL)
    Krishanth Naidu, Pierre H. Chapuis, Kilian G. M. Brown, Charles Chan, Matthew J. F. X. Rickard, Kheng‐Seong Ng
    ANZ Journal of Surgery.2023; 93(7-8): 1861.     CrossRef
  • The impact of laparoscopic, open, extended right, and left colectomy on clinical outcomes of splenic flexure colon cancer: A meta-analysis
    Hefei Cheng, Minjian Zhou, Lianlei Yang, Ziqi Sui
    Medicine.2023; 102(19): e33742.     CrossRef
  • Standardization of the Definition and Surgical Management of Splenic Flexure Carcinoma by an International Expert Consensus Using the Delphi Technique: Room for Improvement?
    Cigdem Benlice, Amjad Parvaiz, Bilgi Baca, Werner Hohenberger, Danilo Miskovic, Luca Stocchi, Scott Steele, Seon-Hahn Kim, Torbjörn Holm, Antonino Spinelli, Ismail Gogenur, Yves Panis, Hirotoshi Hasegawa, Alexey Karachun, Juan C. Patron Uriburu, Masaki It
    Diseases of the Colon & Rectum.2023; 66(6): 805.     CrossRef
  • Laparoscopic complete mesocolic excision with central vascular ligation for splenic flexure colon cancer: short- and long-term outcomes
    Kazuki Ueda, Koji Daito, Hokuto Ushijima, Yoshinori Yane, Yasumasa Yoshioka, Tadao Tokoro, Masayoshi Iwamoto, Toshiaki Wada, Yusuke Makutani, Junichiro Kawamura
    Surgical Endoscopy.2022; 36(4): 2661.     CrossRef
  • Laparoscopic versus open surgery for left flexure colon cancer: A propensity score matched analysis from an international cohort
    Corrado Pedrazzani, Giulia Turri, Soo Yeun Park, Koya Hida, Yudai Fukui, Jacopo Crippa, Giovanni Ferrari, Matteo Origi, Gaya Spolverato, Matteo Zuin, Sung Uk Bae, Seong Kyu Baek, Andrea Costanzi, Dario Maggioni, Gyung Mo Son, Andrea Scala, Timothy Rockall
    Colorectal Disease.2022; 24(2): 177.     CrossRef
  • Emergency surgery for obstructive splenic flexure colon cancer: results of a multicentric study of the French Surgical Association (AFC)
    Camélia Labiad, Gilles Manceau, Diane Mege, Antoine Cazelles, Thibault Voron, Valérie Bridoux, Zaher Lakkis, Solafah Abdalla, Mehdi Karoui, Aurélien Venara, Mehdi Ouaissi, Charles Sabbagh, Tatiana Codjia, Marie Dazza, Guillaume Gagnat, Servane Hamel, Laur
    Updates in Surgery.2022; 74(1): 107.     CrossRef
  • What Is the Optimal Elective Colectomy for Splenic Flexure Cancer: End of the Debate? A Multicenter Study From the GRECCAR Group With a Propensity Score Analysis
    Gilles Manceau, Arnaud Alves, Hélène Meillat, Léonor Benhaïm, Mehdi Ouaïssi, Yves H. Panis, Jean-Jacques Tuech, Bertrand Dousset, Cécile Brigand, Eddy Cotte, Zaher Lakkis, Bogdan Badic, Frédéric Marchal, Charles Sabbagh, Momar Diouf, Mehdi Karoui
    Diseases of the Colon & Rectum.2022; 65(1): 55.     CrossRef
  • Segmental resection of splenic flexure colon cancers provides an adequate lymph node harvest and is a safe operative approach – an analysis of the ACS-NSQIP database
    Allison J. Pang, Daniel Marinescu, Nancy Morin, Carol-Ann Vasilevsky, Marylise Boutros
    Surgical Endoscopy.2022; 36(8): 5652.     CrossRef
  • A Comparison between Different Management Surgical Approaches in the Treatment of Splenic Flexure Colon Cancer
    Elsayed I. El-Hendawy, Mohamed Farouk Amin, Ahmed M. Fahmy, Ahmed Z. Alattar, Shereen Elshorbagy, Ola A. Harb, Ahmed Fathy Gomaa, Ahmed Embaby, Ahmed M. Elsayed, Gamal Osman, Ramadan M. Ali
    Journal of Coloproctology.2022; 42(01): 047.     CrossRef
  • Comparison of laparoscopic and open colectomy for splenic flexure colon cancer: a systematic review and meta-analysis
    Jini Wu, Bo Li, Shiliang Tu, Boan Zheng, Bingchen Chen
    International Journal of Colorectal Disease.2022; 37(4): 757.     CrossRef
  • Surgical Treatment of SplenicFlexure Colon Cancer: Analysisof Short-Term and Long-Term Outcomes of Three DifferentSurgical Procedures
    Mingjin Huang, Xiaojie Wang, Yu Shao, Shenghui Huang, Ying Huang, Pan Chi
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Extended right colectomy, left colectomy, or segmental left colectomy for splenic flexure carcinomas: a European multicenter propensity score matching analysis
    Nicola de’Angelis, Aleix Martínez-Pérez, Des C. Winter, Filippo Landi, Giulio Cesare Vitali, Bertrand Le Roy, Federico Coccolini, Francesco Brunetti, Valerio Celentano, Salomone Di Saverio, Frederic Ris, David Fuks, Eloy Espin
    Surgical Endoscopy.2021; 35(2): 661.     CrossRef
  • Segmental versus extended colectomy for tumours of the transverse colon: a systematic review and meta‐analysis
    Stefan Morarasu, Cillian Clancy, Catherine T Cronin, Takeru Matsuda, Helen M Heneghan, Desmond C Winter
    Colorectal Disease.2021; 23(3): 625.     CrossRef
  • Laparoscopic Colectomy for Splenic Flexure Cancer Approached from Four Directions
    Hiroki Hashida, Masato Kondo, Ryosuke Kita, Koji Kitamura, Kenji Uryuhara, Hiroyuki Kobayashi, Satoshi Kaihara
    Journal of Laparoendoscopic & Advanced Surgical Techniques.2021; 31(9): 1014.     CrossRef
  • Bowel function recovery after laparoscopic transverse colectomy within an ERAS program: a comparison to right and left colectomy
    Raffaello Roesel, Francesco Mongelli, Costanza Ajani, Fabiano Iaquinandi, Diana Celio, Dimitri Christoforidis
    Langenbeck's Archives of Surgery.2021; 406(5): 1563.     CrossRef
  • Emergency surgery for splenic flexure cancer: results of the SFC Study Group database
    Nicola de’Angelis, Eloy Espin, Frederic Ris, Filippo Landi, Bertrand Le Roy, Federico Coccolini, Valerio Celentano, Angela Gurrado, Denis Pezet, Giorgio Bianchi, Riccardo Memeo, Giulio C. Vitali, Alejandro Solis, Christine Denet, Salomone Di Saverio, Gian
    World Journal of Emergency Surgery.2021;[Epub]     CrossRef
  • Primary tumor resection improves prognosis of unresectable carcinomas of the transverse colon including flexures with liver metastasis: a preliminary population-based analysis
    Jiefeng Zhao, Jinfeng Zhu, Rui Sun, Chao Huang, Rongfa Yuan, Zhengming Zhu
    BMC Cancer.2021;[Epub]     CrossRef
  • Short- and long-term outcomes of laparoscopic segmental left colectomy for splenic flexure colon cancer: comparison with propensity score matching
    Moon Jin Kim, Ji Hoon Kim, Yoon Suk Lee, Bong Hyeon Kye, Hyeon Min Cho, Hyung Jin Kim, Won Kyung Kang
    Annals of Surgical Treatment and Research.2021; 101(5): 274.     CrossRef
  • Surgical treatment of a colon neoplasm of the splenic flexure: a multicentric study of short‐term outcomes
    G. A. Binda, A. Amato, G. Alberton, M. Bruzzone, P. Secondo, J. Lòpez‐Borao, R. Giudicissi, A. Falato, C. Fucini, F. Bianco, S. Biondo
    Colorectal Disease.2020; 22(2): 146.     CrossRef
  • Laparoscopic resection with complete mesocolic excision for splenic flexure cancer: long-term follow-up data from a multicenter retrospective study
    Umberto Bracale, Giovanni Merola, Giusto Pignata, Francesco Corcione, Felice Pirozzi, Diego Cuccurullo, Giovanni Domenico De Palma, Elisa Cassinotti, Antonio Sciuto, Luigi Boni
    Surgical Endoscopy.2020; 34(7): 2954.     CrossRef
  • Elective surgery for tumours of the splenic flexure: a French inter-group (AFC, SFCD, FRENCH, GRECCAR) survey
    G. Manceau, S. Benoist, Y. Panis, A. Rault, M. Mathonnet, D. Goere, J. J. Tuech, D. Collet, C. Penna, M. Karoui
    Techniques in Coloproctology.2020; 24(2): 191.     CrossRef
  • Laparoscopic segmental left colectomy for splenic flexure carcinoma: a single institution experience
    Q. Chenevas-Paule, B. Trilling, P. Y. Sage, E. Girard, J. L. Faucheron
    Techniques in Coloproctology.2020; 24(1): 41.     CrossRef
  • Mid-transverse colon cancer and extended versus transverse colectomy: Results of the Italian society of surgical oncology colorectal cancer network (SICO CCN) multicenter collaborative study
    M. Milone, M. Degiuli, M.E. Allaix, C.A. Ammirati, G. Anania, A. Barberis, A. Belli, P.P. Bianchi, F. Bianco, C. Bombardini, M. Burati, D. Cavaliere, C. Coco, A. Coratti, R. De Luca, G. De Manzoni, P. De Nardi, M. De Rosa, P. Delrio, A. Di Cataldo, A. Di
    European Journal of Surgical Oncology.2020; 46(9): 1683.     CrossRef
  • Which is more important in the management of splenic flexure colon cancer: strict central lymph node dissection or adequate bowel resection margin?
    Y. Yamaoka, A. Shiomi, H. Kagawa, H. Hino, S. Manabe, S. Kato, M. Hanaoka
    Techniques in Coloproctology.2020; 24(8): 873.     CrossRef
  • Laparoscopic left hemicolectomy with regional lymph node navigation and intracorporeal anastomosis for splenic flexure colon cancer
    Yoshiro Itatani, Kenji Kawada, Koya Hida, Yasunori Deguchi, Nobu Oshima, Rei Mizuno, Toshiaki Wada, Tomoaki Okada, Yoshiharu Sakai
    International Cancer Conference Journal.2020; 9(4): 170.     CrossRef
  • Comparison of extended right hemicolectomy, left hemicolectomy and segmental colectomy for splenic flexure colon cancer: a systematic review and meta‐analysis
    S. Hajibandeh, S. Hajibandeh, I. Hussain, A. Zubairu, F. Akbar, A. Maw
    Colorectal Disease.2020; 22(12): 1885.     CrossRef
  • Segmental Colonic Resection Is a Safe and Effective Treatment Option for Colon Cancer of the Splenic Flexure: A Nationwide Retrospective Study of the Italian Society of Surgical Oncology–Colorectal Cancer Network Collaborative Group
    Maurizio Degiuli, Rossella Reddavid, Fulvio Ricceri, Francesca Di Candido, Monica Ortenzi, Ugo Elmore, Claudio Belluco, Riccardo Rosati, Marco Guerrieri, Antonino Spinelli
    Diseases of the Colon & Rectum.2020; 63(10): 1372.     CrossRef
  • Clinical–Pathologic Characteristics and Long-term Outcomes of Left Flexure Colonic Cancer: A Retrospective Analysis of an International Multicenter Cohort
    Corrado Pedrazzani, Giulia Turri, Soo Yeun Park, Koya Hida, Yudai Fukui, Jacopo Crippa, Giovanni Ferrari, Matteo Origi, Gaya Spolverato, Matteo Zuin, Sung Uk Bae, Seong Kyu Baek, Andrea Costanzi, Dario Maggioni, Gyung Mo Son, Andrea Scala, Timothy Rockall
    Diseases of the Colon & Rectum.2020; 63(12): 1593.     CrossRef
  • Short- and long-term outcomes after transverse versus extended colectomy for transverse colon cancer. A systematic review and meta-analysis
    Marco Milone, Michele Manigrasso, Ugo Elmore, Francesco Maione, Nicola Gennarelli, Fabio Rondelli, Nunzio Velotti, Giovanni Domenico De Palma
    International Journal of Colorectal Disease.2019; 34(2): 201.     CrossRef
  • Non-anatomical colonic resections: splenic flexure and transverse colectomy. Central vascular ligation is crucial for survival
    Rossella Reddavid, Laura Esposito, Andrea Evangelista, Silvia Sofia, Maurizio Degiuli
    Minerva Chirurgica.2019;[Epub]     CrossRef
  • Is Segmental Colon Resection an Alternative Treatment for Splenic Flexure Cancer?
    Refik Bademci, Jesus Bollo, C. Martinez Sanchez, Pilar Hernadez, Eduardo Maria Targarona
    Journal of Laparoendoscopic & Advanced Surgical Techniques.2019; 29(5): 621.     CrossRef
  • Laparoscopic resection of splenic flexure colon cancer – a video vignette
    G. Lisi, G. M. Garbarino, R. Del Giudice, D. Spoletini, M. Carlini
    Colorectal Disease.2019; 21(9): 1090.     CrossRef
  • Treatment of splenic flexure colon cancer: a comparison of three different surgical procedures: Experience of a high volume cancer center
    Daniela Rega, Ugo Pace, Dario Scala, Paolo Chiodini, Vincenza Granata, Andrea Fares Bucci, Biagio Pecori, Paolo Delrio
    Scientific Reports.2019;[Epub]     CrossRef
  • Intracorporeal Versus Extracorporeal Anastomosis for Laparoscopic Resection of the Splenic Flexure Colon Cancer: A Multicenter Propensity Score Analysis
    Michele Grieco, Diletta Cassini, Domenico Spoletini, Enrica Soligo, Emanuela Grattarola, Gianandrea Baldazzi, Silvio Testa, Massimo Carlini
    Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2019; 29(6): 483.     CrossRef
  • Analysis of prognosis, genome, microbiome, and microbial metabolome in different sites of colorectal cancer
    Yang Xi, Pan Yuefen, Wu Wei, Qi Quan, Zhuang Jing, Xu Jiamin, Han Shuwen
    Journal of Translational Medicine.2019;[Epub]     CrossRef
  • Subtotal colectomy versus left hemicolectomy for the elective treatment of splenic flexure colonic neoplasia
    Marc Beisani, Francesc Vallribera, Albert García, Laura Mora, Sebastiano Biondo, Jaime Lopez-Borao, Ramon Farrés, Júlia Gil, Eloy Espin
    The American Journal of Surgery.2018; 216(2): 251.     CrossRef
  • Lymphatic Drainage of the Splenic Flexure Defined by Intraoperative Scintigraphic Mapping
    Carolyn E. Vasey, Siraj Rajaratnam, Gregory O’Grady, Mike Hulme-Moir
    Diseases of the Colon & Rectum.2018; 61(4): 441.     CrossRef
  • Robotic left colectomy with complete mesocolectomy for splenic flexure and descending colon cancer, compared with a laparoscopic procedure
    Jin Cheon Kim, Jong Lyul Lee, Yong Sik Yoon, Chan Wook Kim, In Ja Park, Seok‐Byeong Lim
    The International Journal of Medical Robotics and Computer Assisted Surgery.2018;[Epub]     CrossRef
  • Propensity score analysis of postoperative and oncological outcomes after surgical treatment for splenic flexure colon cancer
    J. Martín Arévalo, D. Moro-Valdezate, S. A. García-Botello, V. Pla-Martí, M. Garcés-Albir, L. Pérez Santiago, A. Vargas-Durán, A. Espí-Macías
    International Journal of Colorectal Disease.2018; 33(9): 1201.     CrossRef
  • How we do it: totally laparoscopic complete mesocolon excision for splenic flexure cancer
    Paolo Panaccio, Tommaso Grottola, Marco Ricciardiello, Pierluigi di Sebastiano, F. Francesco di Mola
    Langenbeck's Archives of Surgery.2018; 403(6): 769.     CrossRef
  • Long-term oncologic outcomes of laparoscopic surgery for splenic flexure colon cancer are comparable to conventional open surgery
    Min Ki Kim, In Kyu Lee, Won-Kyung Kang, Hyeon-Min Cho, Bong-Hyeon Kye, Heba Essam Jalloun, Jun-Gi Kim
    Annals of Surgical Treatment and Research.2017; 93(1): 35.     CrossRef
  • Surgical Treatment of Colon Cancer of the Splenic Flexure: A Systematic Review and Meta-analysis
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    Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2017; 27(5): 318.     CrossRef
  • Laparoscopic extended right colectomy versus laparoscopic left colectomy for carcinoma of the splenic flexure: a matched case–control study
    Nicola de’Angelis, Elisabeth Hain, Mara Disabato, Cristiana Cordun, Maria Clotilde Carra, Daniel Azoulay, Francesco Brunetti
    International Journal of Colorectal Disease.2016; 31(3): 623.     CrossRef
  • Laparoscopic resection of splenic flexure tumors
    Massimo Carlini, Domenico Spoletini, Fabio Castaldi, Cristiano Giovannini, Umberto Passaro
    Updates in Surgery.2016; 68(1): 77.     CrossRef
  • Operative Method for Transverse Colon Carcinoma: Transverse Colectomy Versus Extended Colectomy
    Choon Seng Chong, Jung Wook Huh, Bo Young Oh, Yoon Ah Park, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee
    Diseases of the Colon & Rectum.2016; 59(7): 630.     CrossRef
  • Optimum Level of Vessel Ligation in Splenic Flexure Cancer
    Kim Nam Kyu
    Journal of Surgery and Surgical Research.2016; : 055.     CrossRef
  • Splenic flexure colon cancers: minimally invasive treatment
    Valentino Fiscon, Giuseppe Portale, Giovanni Migliorini, Flavio Frigo
    Updates in Surgery.2015; 67(1): 55.     CrossRef
  • Laparoscopic colonic resection for splenic flexure cancer: our experience
    Andrea Pisani Ceretti, Nirvana Maroni, Matteo Sacchi, Stefano Bona, Maria Rachele Angiolini, Paolo Bianchi, Enrico Opocher, Marco Montorsi
    BMC Gastroenterology.2015;[Epub]     CrossRef
  • The short- and long-term outcomes for patients with splenic flexure tumours treated by left versus extended right colectomy are comparable: a retrospective analysis
    Manfred Odermatt, Najaf Siddiqi, Rose Johns, Danilo Miskovic, Omar Khan, Jim Khan, Amjad Parvaiz
    Surgery Today.2014; 44(11): 2045.     CrossRef
  • Elective subtotal colectomy with ileosigmoid anastomosis for colon cancer preserves bowel function and quality of life
    G. Manceau, E. d'Annunzio, M. Karoui, S. Breton, G. Rousseau, A. S. Blanchet, J. C. Vaillant, L. Hannoun
    Colorectal Disease.2013; 15(9): 1078.     CrossRef
  • Totally laparoscopic resection of the splenic flexure for tumor
    Francesco Roscio, Camillo Bertoglio, Antonio De Luca, Paolo Frattini, Federico Clerici, Ildo Scandroglio
    Updates in Surgery.2012; 64(3): 185.     CrossRef
  • Does the outcome of colonic flexure cancers differ from the other colonic sites?
    Irshad A. Shaikh, Stuart A. Suttie, Mary Urquhart, Amin I. Amin, Thomas Daniel, Satheesh Yalamarthi
    International Journal of Colorectal Disease.2012; 27(1): 89.     CrossRef
  • Colon Cancer in the Splenic Flexure
    Masayuki Nakashima, Takashi Akiyoshi, Masashi Ueno, Yosuke Fukunaga, Satoshi Nagayama, Yoshiya Fujimoto, Tsuyoshi Konishi, Rota Noaki, Keiko Yamakawa, Yasutomo Nagasue, Hiroya Kuroyanagi, Toshiharu Yamaguchi
    Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2011; 21(6): 415.     CrossRef
  • 12,877 View
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Optimal Timing for the Administration of Capecitabine with Preoperative Chemoradiation for Locally Advanced Rectal Cancer
Young Ju Noh, Won Sik Choi, Jong Hoon Kim, Jin Cheon Kim, Chang Sik Yu, Hee Cheol Kim, Tae Won Kim, Heung Moon Chang, Min Hee Ryu, Seung Do Ahn, Sang-wook Lee, Seong Soo Shin, Jung Eun Lee, Eun Kyung Choi
Cancer Res Treat. 2006;38(1):30-34.   Published online February 28, 2006
DOI: https://doi.org/10.4143/crt.2006.38.1.30
AbstractAbstract PDFPubReaderePub
Purpose

Capecitabine is an oral fluoropyrimidine carbamate and it is known as an effective radiosensitizer. Capecitabine and its metabolite reach their peak concentration in the plasma at 1~2 hours after a single oral administration of capecitabine and the levels fall rapidly thereafter. To verify the radiosensitizing effect of capecitabine that is based on such pharmacokinetic characteristics, we performed a retrospective analysis on the optimal timing of capecitabine administration with performing preoperative chemoradiation for locally advanced rectal cancer.

Materials and Methods

Among 171 patients who were treated with preoperative radiotherapy and concurrent capecitabine administration for rectal cancer, 56 patients were administered capecitabine at 1~2 hours before radiotherapy (group A), and at other time in the other 115 patients (group B). Total mesorectal excision was done at 4 to 6 weeks after the completion of chemoradiation. The radiosensitizing effect of capecitabine was evaluated on the basis of the pathological response.

Results

Complete pathological regression of the primary tumor was observed in 12 patients (21.4%) for group A and in 11 patients (9.6%) for group B (p=0.031). Residual disease less than 0.5 cm (a good response) was observed in 19 patients (33.9%) for group A and in 23 patients (20.0%) for group B (p=0.038). On multivariate analysis, the capecitabine ingestion time showed marginal significance.

Conclusion

When performing preoperative chemoradiation for locally advanced rectal cancer, the radiosensitizing effect of capecitabine was enhanced when it was administered 1 hour before radiotherapy.

Citations

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  • Systematic review of treatment intensification using novel agents for chemoradiotherapy in rectal cancer
    R Clifford, N Govindarajah, J L Parsons, S Gollins, N P West, D Vimalachandran
    British Journal of Surgery.2018; 105(12): 1553.     CrossRef
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Case Report
Lymph Node Metastases of Prostatic Adenocarcinoma in the Mesorectum in Patients with Rectal Cancer
In Ja Park, Hee Cheol Kim, Chang Sik Yu, Choung Soo Kim, Jung Sun Kim, Jin Cheon Kim
Cancer Res Treat. 2005;37(2):129-132.   Published online April 30, 2005
DOI: https://doi.org/10.4143/crt.2005.37.2.129
AbstractAbstract PDFPubReaderePub

Lymph node involvement is the most important prognostic factor of rectal cancer. Cancer originating from sites other than the rectum rarely metastasizes to the mesorectal lymph node. We report a rectal cancer patient with a synchronous metastatic prostatic carcinoma to the mesorectal lymph node.

Citations

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  • A Case of Prostate Cancer Diagnosed by the Discovery of Pararectal Lymph Node Metastases during Sigmoid Colon Cancer Surgery
    Daiki KATO, Chieko KITAMURA, Jun YAMADA
    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2023; 84(9): 1515.     CrossRef
  • A Case of Rectal Cancer with Lymph Node Metastasis of Prostate Cancer in the Mesorectum after Radical Prostatectomy
    Teruhisa UDAGAWA, Yu SUZUKI, Yasushi ITO, Yoshihisa TAMATE, Naoki YANAGAWA, Takashi KAMEI
    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2022; 83(4): 775.     CrossRef
  • Two Cases of Colorectal Cancer with Mesenteric Lymph Node Metastasis Derived from Prostatic Cancer
    Fumitaka Asahara, Hirotoshi Hasegawa, Shutaro Suda, Emima Bekku, Kazuhiko Hashimoto, Aya Sasaki, Junichi Matsui
    The Japanese Journal of Gastroenterological Surgery.2020; 53(1): 61.     CrossRef
  • Metastasization of mesorectal lymph nodes by a prostatic adenocarcinoma
    J.J. Arenal, A. Torres, C. Tinoco, M.A. Citores, C. Benito, B. Madrigal, A. Vara
    Human Pathology: Case Reports.2015; 2(2): 42.     CrossRef
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Original Articles
Responsiveness of CPT-11 in Respect to hMLH1 and hMSH2 Protein Expression in the Primary Colorectal Cancer
In Ja Park, Hee Cheol Kim, Chang Sik Yu, Heung Moon Chang, Jea Hwan Lee, Jong Hoon Kim, Tae Won Kim, Jung Sun Kim, Jin Cheon Kim
Cancer Res Treat. 2004;36(6):360-366.   Published online December 31, 2004
DOI: https://doi.org/10.4143/crt.2004.36.6.360
AbstractAbstract PDFPubReaderePub
Purpose

The aim of this study was to evaluate the responsiveness to CPT-11 with respect to hMLH1 and hMSH2 protein expressions in primary colorectal tumors.

Materials and Methods

91 patients with colorectal cancer treated having undergone surgery and postoperative CPT-11-based adjuvant chemotherapy, between 1997 and 2002, were prospectively recruited. Tumor samples were immunohistochemically analyzed for the expressions of hMLH1, hMSH2, p53 and CEA proteins.

Results

Of the 91 tumors, 6 (6.6%) and 4 (4.4%) showed loss of hMLH1 and hMSH2 protein expressions, respectively. The response rate of patients with tumors not expressing either hMLH1 or hMSH2 was higher than that of those expressing either of these proteins (p=0.026). Patients with tumors not expressing hMLH1 showed a significantly better response to CPT-11 (p=0.04). The responsiveness was not associated with the expressions of hMSH2, p53 or CEA. There were no correlations between drug toxicity and the expressions of hMLH1, hMSH2 or p53. The overall survival was better in patients responsive to CPT-11-based chemotherapy compared to non-responders.

Conclusion

The immunohistochemical determination of loss of hMLH1 and hMSH2 expressions may be used in determining the responsiveness to CPT-11-based chemotherapy. Our results suggest that hMLH1 protein expression may be a predictor for CPT-11 responsiveness in patients with colorectal cancer.

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Prospective Phase II Study of Preoperative Chemoradiation with Capecitabine in Locally Advanced Rectal Cancer
Jin-hong Park, Jong Hoon Kim, Seung Do Ahn, Sang-wook Lee, Seong Soo Shin, Jin Cheon Kim, Chang Sik Yu, Hee Cheol Kim, Yoon-Koo Kang, Tae Won Kim, Heung Moon Chang, Min Hee Ryu, Eun Kyung Choi
Cancer Res Treat. 2004;36(6):354-359.   Published online December 31, 2004
DOI: https://doi.org/10.4143/crt.2004.36.6.354
AbstractAbstract PDFPubReaderePub
Purpose

Capecitabine is an attractive oral chemotherapeutic agent that has a radiosensitizing effect and tumor-selectivity. This study was performed to evaluate the efficacy and toxicity of preoperative chemoradiation therapy, when used with oral capecitabine, for locally advanced rectal cancer.

Materials and Methods

A prospective phase II trial of preoperative chemoradiation for locally advanced adenocarcinomas of the lower two-thirds of the rectum was conducted. A radiation dose of 50 Gy over five weeks and a daily dose of 1650 mg/m2 capecitabine in two potions was administered during the entire course of radiation therapy. Surgery was performed with standardized total mesorectal excision four to six weeks after completion of the chemoradiation.

Results

Between January 2002 and September 2003, 61 patients were enrolled onto this prospective phase II trial. The pretreatment clinical stages were T3 in 64% (n=39), T4 in 36% (n=22) and N1-2 in 82% (n=50) of these patients. Fifty-six (92%) patients completed the chemoradiation as initially planned and a complete resection performed in 58 (95%). Down-staging was observed in 45 patients (74%) and a pathologic complete response in 6 (10%). Among the 37 patients with tumors located within 5 cm from the anal verge on colonoscopy, 27 (73%) underwent a sphincter-preserving procedure. No grade 3 and 4 proctitis or hematological toxicities were observed.

Conclusion

Preoperative chemoradiation therapy with capecitabine achieved encouraging rates of tumor downstaging and sphincter preservation, with a low toxicity profile. This combined modality can be regarded as a safe and effective treatment for locally advanced rectal cancer.

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  • MRI for Rectal Cancer: Staging, mrCRM, EMVI, Lymph Node Staging and Post-Treatment Response
    David D.B. Bates, Maria El Homsi, Kevin J. Chang, Neeraj Lalwani, Natally Horvat, Shannon P. Sheedy
    Clinical Colorectal Cancer.2022; 21(1): 10.     CrossRef
  • MRI of Rectal Cancer: An Overview and Update on Recent Advances
    Kartik S. Jhaveri, Hooman Hosseini-Nik
    American Journal of Roentgenology.2015; 205(1): W42.     CrossRef
  • Current Controversies in Neoadjuvant Chemoradiation of Rectal Cancer
    P. Terry Phang, Xiaodong Wang
    Surgical Oncology Clinics of North America.2014; 23(1): 79.     CrossRef
  • Tailored rectal cancer treatment – a time for implementing contemporary prognostic factors?
    A. Wibe, W. L. Law, V. Fazio, C. P. Delaney
    Colorectal Disease.2013; 15(11): 1333.     CrossRef
  • Oncologic Outcome After Preoperative Chemoradiotherapy in Patients With Pathologic T0 (ypT0) Rectal Cancer
    Tae Young Jang, Chang Sik Yu, Yong Sik Yoon, Seok-Byung Lim, Seung-Mo Hong, Tae Won Kim, Jong Hoon Kim, Jin Cheon Kim
    Diseases of the Colon & Rectum.2012; 55(10): 1024.     CrossRef
  • Phase II study of concurrent chemoradiotherapy with capecitabine and cisplatin in patients with locally advanced squamous cell carcinoma of the head and neck
    J G Kim, S K Sohn, D H Kim, J H Baek, S B Jeon, Y S Chae, K B Lee, J S Park, J H Sohn, J C Kim, I K Park
    British Journal of Cancer.2005; 93(10): 1117.     CrossRef
  • Preoperative Concurrent Chemoradiotherapy with Oral Fluoropyrimidine in Locally Advanced Rectal Cancer: How Good Is Good Enough?
    Hyun Cheol Chung
    Cancer Research and Treatment.2004; 36(6): 341.     CrossRef
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Case Report
Isolated Diaphragmatic Metastasis Originated from Adenocarcinoma of the Colon
Kang Hong Lee, Chang Sik Yu, Hwan Namgung, Hee Cheol Kim, Jin Cheon Kim
Cancer Res Treat. 2004;36(2):157-159.   Published online April 30, 2004
DOI: https://doi.org/10.4143/crt.2004.36.2.157
AbstractAbstract PDFPubReaderePub

Isolated diaphragmatic metastasis arising from colorectal cancer has been reported only one case in the literature presently. Here, we presented a new case and discussed the possible pathogenesis and the treatment options. A 42-year-old male patient had received anterior resection for sigmoid colon cancer. Although the increased serum CEA level was detected 20 months after the surgery, metastatic lesion could not be detected by repeated colonoscopy, CT scan, bone scan or PET scan for 35 months. We could detect a suspicious metastatic lesion on the liver by CT scan at 56 month after the surgery. During a second-look operation, we found a solitary metastasis on the diaphragm and removed it along with the 1 cm tumor-free resection margin. Although the prognosis associated with skeletal metastasis is poor, the complete resection of isolated diaphragmatic metastasis and subsequent appropriate adjuvant chemotherapy may achieve a cure the disease provided that other metastatic lesions are absent.

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Original Articles
Patterns of Failure and Prognostic Factors in Anal Cancer Treated with Radiotherapy
Kyoung Ju Kim, Jong Hoon Kim, Eun Kyung Choi, Seung Do Ahn, Sang Wook Lee, Jin Cheon Kim, Chang Sik Yu, Hee Cheol Kim, Je Hwan Lee, Tae Won Kim
Cancer Res Treat. 2003;35(2):141-147.   Published online April 30, 2003
DOI: https://doi.org/10.4143/crt.2003.35.2.141
AbstractAbstract PDF
PURPOSE
To analyze the patterns of failure and prognostic factors affecting the local control and survivals in anal cancer treated with definitive radiotherapy, and to find the most effective treatment modality. MATERIALS AND METHODS: Thirty consecutive patients, with primary cancers of the anal canal, were treated using radiotherapy, both with and without 5-FU based concurrent chemotherapy. According to the AJCC tumor stage, six patients hadwere stage I, 11 had stage II, 2 had stage IIIA, and 11 had stage IIIB tumors. The median radiation dose was 45 Gy (30-72 Gy), and with 23 patients receivinged concurrent chemotherapy (5-FU and mitomycin C in 12 patients, 5-FU and cisplatin in 7, and other drugs in 4). The Mmedian follow up period was 43 months, (ranginge, from 8- to 99 months). RESULTS: Among the 1630 patients who16 were treated without surgical resection beforeprior to the radiotherapy, and a complete remission was observed in 12 patients (75%), a partial remission in 3 (19%), and a local progression in the other one patient. The Llocal failures, including persistent disease, were observed in 10 (33%), and the patients with higher T-stages (T3-4) had higher rates of local failure rates (T1-2, 21% vs. T3-4, 72%, p=0.03). Distant metastases were found in 4 patients (13%). The five year survival and disease free survival rates were 64% and 53%, respectively. The factors which affectinged the 5 year local relapse free survival were T-stage (74.9% in T1-2 vs. 28.6% in T3-4, p=0.01), and the existence of a gross tumor beforeprior to radiotherapy (84.6%, no residual vs. 45.1% with residual, p=0.03).
CONCLUSION
A Llocal recurrence was the major failure pattern in anal cancers, and the factors affecting a local failure were the T-stage and tumor volume beforeprior to radiotherapy. A Rradiation dose around 45 Gy was sufficient to control tumors of the earlier T stage tumors, but a higher dose should be considered for with more advanced lesions.
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Somatic Mutations of APC Presenting Polymorphisms in the Hamartomatous Polyps of the Colon
Jin Cheon Kim, Seon Ae Roh, Hee Cheol Kim, Chang Sik Yu, Nichoias E Beck, Walter F Bodmer
J Korean Cancer Assoc. 1999;31(6):1288-1296.
AbstractAbstract PDF
No abstract available.
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In Vitro Chemosensitivity Test for the Evaluation of Efficiency of Hyperthermia in Gastrointestinal Cancer Cell Lines
Jeong Hwan Yook, Byeong Yul Ahn, Geum Hee Koo, Hun Seo, Choon Sik Jeong, Sung Tae Oh, Byung Sik Kim, Kun Chun Park, Jin Cheon Kim
J Korean Cancer Assoc. 1999;31(5):931-938.
AbstractAbstract PDF
PURPOSE
This study was designed to establish the experimental background of intra- peritoneal hyperthermo-chemotherapy in gastrointestinal cancer.
MATERIALS AND METHODS
We established stomach cancer cell lines; KATO-III, MKN45, AMC1 and colon cancer cell lines; AMC5, AMC6, CloneA, CCL188, C106, KM-12C. We performed chemosensitivity test by using MTT assay and calculated ICso of each chemotherapeutic agent. We confirmed antitumor effect of hyperthermia at 40C and 43C and antitumor synergistic effect with each chemotherapeutic agent at 40C and 43C.
RESULTS
The ICso was calculated in 7 (78%) of 9 cell lines for 5-FU, 6 (67%) for MMC, 5 (56%) for ADM, 1 (11%) for CDDP and VP-16. Antitumor effect of hyperthermia at 40C was not found, but, that at 43C was found except KATO-III and AMC6. In stomach cancer cell lines, antitumor synergistic effect of hyperthermia with anticancer drugs at 43C was found in VP-16 for MKN45 and KATO-III and in all of 5 drugs for AMC1. In colon cancer cell lines, this effect at 43C was found in all of 5 drugs for CCL188, in S-FU, CDDP, ADM for AMC5, in 5-FU, MMC, ADM, VP-16 for CloneA, KM-12C, and in 5-FU, CDDP, MMC, ADM for C106.
CONCLUSION
Hyperthermia itself had antitumor effect at 43C. Hyperthermo-chemotherapy had antitumor synergistic effect, especially at 43C.
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Treatment of Hepatic Metastasis of Colorectal Cancer: A Retrospective Analysis of the Outcome in 99 Patients
Jin Cheon Kim, Chang Nam Kim, Chang Sik Yu, Han Il Lee, Sang We Kim, Je Hwan Lee, Woo Kun Kim, Gyeong Hoon Kang, Moon Kyu Lee
J Korean Cancer Assoc. 1998;30(6):1175-1183.
AbstractAbstract PDF
PURPOSE
Among various modalities of treatment in hepatic metastasis of colorectal cancer, hepatic resection has been proven to be the most effective treatment. This analysis was intended to determine important prognostic parameters and to understand clinically significant factors during hepatic resection and follow-up period in patients with hepatic metastasis from colorectal cancer.
MATERIALS AND METHODS
Among 1,022 colorectal cancer patients treated at Asan Medical Center from July 1989 to December 1995, 99 patients were found to have liver metastasis at the time of first diagnosis or during follow-up period. These 99 patients were the subject of analysis in this retrospective clinical study. Surgical resection with curative intent was done in 35 patients and chemotherapy in 46 patients. Eighteen patients were with no treatment or misssed during follow-up. Survival rate was analysed according to clinicopathological parameters: sex, age, location of primary tumor, preoperative serum CEA level, TNM staging of primary tumor, number of hepatic metastasis, distribution, synchronous or metachronous lesions, diesase free interval, mode of treatment, type of resection, tumor free resection margin.
RESULTS
Overall survival of the patients with hepatic metastasis was significantly related with numbers of metastasis (<4 vs. >4), distribution (unilobar vs. bilobar), synchronous or metachronous lesions, disease free interval ( < 12 vs. > 12 months), mode of treatment (hepatic resection vs. chemotherapy vs, no treatment, p<0.01. A multivariate analysis showed a significant association of survival with mode of treatment (p<0.01). Survival of patients with hepatic resection was significantly related with resection margin (positive vs. < 1 cm vs. > 1 cm), TNM staging of primary tumor (II vs. III), number of hepatic metastasis (p<0.01), disease free interval (p<0.05). A multivariate analysis showed a significant correlation with survival for tumor free resection margin (p<0.01).
CONCLUSION
An aggressive approach of hepatic resection in the colorectal liver metastasis will improve survival, if the lesion pennits. In patients with hepatic resection, tumor free resection margin was the most important prognostic parameter by the uniand multivariate analysis. Therefore, every effort should be made to ensure that the clear margin be kept at least more than 1 cm during hepatic resection.
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Genomic Identification of N-Trminal Domail Exons of Carcinoembryonic Antigen in Human Colon Carcinoma
Jin Cheon Kim, Sun Ae Noh, Kun Choon Park, In Kwon Jung
J Korean Cancer Assoc. 1998;30(4):675-682.
AbstractAbstract PDF
No abstract available.
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Multiple Primary Malignant Neoplasm with Colorectal Cancer
Hee Chul Kim, Chang Nam Kim, Chun Sik Jung, Chang Sik Yu, Jin Cheon Kim
J Korean Cancer Assoc. 1998;30(4):668-674.
AbstractAbstract PDF
PURPOSE
The incidence of multiple primary malignant neoplasm has increased in recent decades. The etiologies and epidemiologies of multiple primary malignant neoplasm are still remained to be verified. A group of patients with multiple primary malignant neoplasms accompanied by colorectal cancer was analyzed to determine the relationship between certain cancers and colorectal cancer.
MATERIALS AND METHODS
From Jan. 1989 to Jun 1997, there were 56 patients with colorectal cancers accompanied by cancers of another organs. The retrospective analysis was done on the basis of cancer origin and intervals between the cancers.
RESULTS
The male-to-female ratio was 25 to 31. The characteristics of colorectal cancers in multiple primary malignant neoplasm were similar to the colorectal cancers without other cancers. Among 56 patients, 50 patients had the double primaries and 6 had the triple primaries. In the patients with double primaries, extracolonic cancers were found in the stomach(16), hepatobiliary system(12), urologic system(6), gynecologic organ(6) and others. In the patients with triple primaries, extracolic cancers were found in the stomach(5), uterus(2), lung(2) and others. The patients with family history of malignancy were 10 cases and the rate in the triple primaries seemed to be higher than double primaries.
CONCLUSION
It could be desirable to follow-up and work-up the patients with colorectal cancer keeping in mind that the malignancy in other organs especially stomach might be present.
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Primary Signet Ring Cell Carcinoma of the Colon and Rectum
Hee Chul Kim, Chang Nam Kim, Choon Sik Jeong, Chang Sik Yu, Byung Sik Kim, Hun Kyung Lee, Jin Cheon Kim
J Korean Cancer Assoc. 1998;30(3):521-526.
AbstractAbstract PDF
PURPOSE
Signet ring cell carcinoma is a rare type of adenocarcinoma in the colon and rectum. We evaluated the differences of clinical features between colorectal signet ring cell carcinoma and ordinary adenocarcinoma.
MATERIALS AND METHODS
The clincopathologic data of 13 cases with primary colorectal signet ring cell carcinoma were reviewed. The primary colorectal signet ring cell carcinoma was diagnosed when following criteria were met: 1) the tumor was primary; 2) histologic material was adequate; 3) signet ring cells represented more than 50% of the cancer.
RESULTS
Patients ranged in age from 20 to 68 (median, 45) years; 7 were male, and 6 were female. Three tumors were located in the proximal colon, 3 in the distal colon, and 7 in the rectum. There was no case that had family history. Most cases (77%) were stage III, one was stage II, and two were stage IV with peritoneal seeding. There were 9 cases that showed local recurrence or distant metastases during follow-up periods 6 cases with peritoneal seeding, 3 with bone metastases, 2 with brain metastases and 1 with pelvic recurrence (two cases had either bone and brain metastasis, and one case had bone and peritoneal seeding). Prognosis was extremely poor, and overall two years survival rate was 25%. CONCLUSION: Early onset, mode of metastasis and poor prognosis may imply the different biologic behavior of signet ring cell carcinoma, compared with ordinary adenocarcinoma. To improve outcome, early diagnosis and radical operation should be stressed.
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Microvessel Count and Overexpression of p53 in Early Colorectal Cancer
Young Min Kim, Gyeong Hoon Kang, Suk Kyun Yang, Chang Sik Yu, Jin Cheon Kim
J Korean Cancer Assoc. 1998;30(1):80-88.
AbstractAbstract PDF
PURPOSE
Angiogenesis, playing a critical role in tumor growth, development, and metastatic process, is alleged to be related to the prognostic factors and patient's survival of the colo-rectal cancer. The p53 gene, present in short arm of chromosome 17, is involved in multistep colo-rectal carcinogenesis. The correlation of p53 gene and angiogenesis has been recently reported. So, we designed to assess (1) the rate of p53 overexpression, (2) the prognostic significance of microvessel count, and (3) the relationship of p53 overexpression and angiogenesis in early colo-rectal cancer(ECC) patients. MATERIAL AND METHODS: The study material included 68 ECC from 65 patients, 40 mucosal (m-ECC) and 28 submucosal ECCs (sm-ECC). Immunostainings against p53 and factor VIII-related antigen were done and the results were analyzed with respect to tumor depth, site, and differentiation. And also the correlation between p53 overexpression and microvessel counts(MVC) was performed.
RESULT
The rate of p53 overexpression was higher in sm-ECC than in m-ECC (p < 0.05). The rate of p53 overexpression was highest in sigmoid colon and statistically significantly different compared with other sites. The differentiation of the tumor was closely correlated with p53 overexpression and the poorer the differentiation, the more overexpression of p53 (p<0.05). There was no significant difference between MVCs of m-ECC and sm-ECC (27.2+/-5.5 and 29.8 +/-6.0,respectively). However, MVC were higher in sigmoid colon than in any other sites (p<0.05). MVC did not show significant correlation with tumor differentiation or p53 overexpression.
CONCLUSION
These data indicate that p53 overexpression is correlated with tumor depth and differentiation but not MVC. The significance of higher MVC and p53 overexpression in sigmoid colon are reserved for further studies.
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A Case of the Pancreatic Pseudocyst due to Metastatic Malignant Melanoma
Bong Soo Chung, Jin Cheon Kim, Chang Sik Yu, Han Il Lee, Chang Nam Kim, Duck Jong Han, Gyeong Hoon Kang
J Korean Cancer Assoc. 1997;29(3):528-533.
AbstractAbstract PDF
Malignant melanoma constitutes approximately 1% of all cancer (1,2). As the biologic behavior seems to be unpredictable, variation in the metastatic spread are not infrequently met. The common sites of metastasis are lymph nodes, lung, liver, brain, bone, heart, adrenal glands, and gastrointestinal tract in descending order (2). However multiple organ involvement is a common feature at the advanced stage. A 38-year-old male had developed pancreatic pseudocyst during the course of malignant melanoma at right sole. It was proven to be from matastatic malignant melanoma.
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Hepatic Intraarterial Chemotherapy in Unresectable Hepatic Metastases of Colorectal Cancer
Jin Cheon Kim, Han Il Lee, Chang Sik Yu, Hee Won Chung, Sang Wee Kim, Jeong Sin Lee, Kun Choon Park
J Korean Cancer Assoc. 1997;29(2):227-234.
AbstractAbstract PDF
PURPOSE
Unresectable hepatic metastases of colorectal cancer does not seem to be amenable to the various treatment modalities. We modified hepatic intraarterial chemotherapy by different installation of port and regimen.
MATERIALS AND METHODS
Between July 1989 to December 1995, 27 patients of colorectal cancer with unresectable liver metastases were randomly allocated into either hepatic intraarterial (HA, 11 patients) or systemic intravenous (IV, 16 patients) chemotherapy after primary tumor resection. Chemo-port was installed with preservation of hepatic arterial flow. One cycle of HA regimen included 5-fluorouracil (5-FU) and mitomycin-C (MMC) with or without leucovorin (LV) for 14 days every month. The IV regimen included 5-FU and LV for 5 days every month. Both HA and IV chemotherapy were continued from 6 to 12 cycles.
RESULTS
The response exceeding partial remission was experienced in six patients (55%) among 11 patients in the HA group, while only two (13%) patients showed response among sixteen patients in the IV group. One year survival was not different between two groups. Although lethal toxicity was not found, patients showed marked increase of the performance scale (ECOG) in both groups.
CONCLUSION
Although survival benefit was not prominent, higher response rate with tolerable complication was found in the HA group. Prudent selection of effective drugs and combination of systemic chemotherapy are needed to improve the survival with minimal complication.
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Changes of serum carcinoembryonic antigen in patients with colorectal cancer
Jin Cheon Kim, Dae Yong Hwang, Byung Sik Kim, Young Il Min, Myung Hae Lee, Kun Choon Park
J Korean Cancer Assoc. 1992;24(6):880-884.
AbstractAbstract PDF
No abstract available.
  • 2,796 View
  • 14 Download
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Applicability of DMH-induced colorectal tumor model in respect to carcinogenesis
Jin Cheon Kim, Gyeong Yeop Gong, Kyoo Yeon Park, Byung Sik Kim, Kun Choon Park, In Chul Lee
J Korean Cancer Assoc. 1992;24(2):239-248.
AbstractAbstract PDF
No abstract available.
  • 2,337 View
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Initial results of adenoma culture for adenoma-carcinoma continuum in the colorectal tumor
Jin Cheon Kim, Kyoo Yeon Park, Kun Choon Park, Jae Dam Lee
J Korean Cancer Assoc. 1992;24(2):218-226.
AbstractAbstract PDF
No abstract available.
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Consecutive DNA measurements in synchronous colorectal adenoma and adenocarcinoma
Jin Cheon Kim, Gyoung Yeop Gong, Kun Choon Park, Suk Koo Kim, Jin Hyang Park, In Chul Lee
J Korean Cancer Assoc. 1991;23(4):693-700.
AbstractAbstract PDF
No abstract available.
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Perineal pagent's disease involving the inguinoscrotal area
Jin Cheon Kim, Kun Choon Park, Kyung Suck Koh, Eun Sil Yu, Kyung Jeh Sung
J Korean Cancer Assoc. 1991;23(2):465-469.
AbstractAbstract PDF
No abstract available.
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An Autoradiographic Study on the Progress of 1 , 2-Dimethylhydrazine - Induced Colonic Carcinogenesis in Rats
Jin Cheon Kim, Hye Sung Lee
J Korean Cancer Assoc. 1989;21(2):317-328.
AbstractAbstract PDF
1,2-dimethylhydrazine induced colonic carcinogenesis was performed to examine colsely the preneoplastic changes and progress of colonic carcinoma in rats. Rats were grouped into 5 by differences of chow in their properties of cellulose-composition. For the purpose of reducing the artificial errors, the metabvlic and energy balances among groups were homogenized by the control of metabolic energy and fixation of several nutrients of chow significantly affecting colonic carcinogenesis. At the same time, low-dose and high-frequency injection of DMH was applied for the approximation of natural carcinogenesis. The results were analysed by autoradiography using tritiated thymidine on 18 weeks after start of l)K1H-injection. As compared to the controi, 2 to 27 fold-increase of crypt height, labeled cells, and labeling index were identified in the l)MH-injected. The loss of body weight as well as these findings of significant increase in hyperplastic celis should reveal the preneoplastic changes during that period. Among the cloinic segments, the labeling results showed the highest in the ascending colon and it coincided with thc highest incidence of adenocarcinomn in the same segment. The distributing pattern of labeled cells showed that the lower 1/3 predominated over the middle and upper 1/3 with significant difference, in other words. downward migratory pattern was found. De novo formation rif colonic carcinoma in DMH-induced culonic carcinogenesis in rats was highly suspected clue tv clownward migratory pattern of labeled cells and no adenoma-carcinoma sequence in uur histopathologic results. Incidcnce of colonic adenocarcinoma reduced significantly in the group fed on 20%-cellulose containing group compared to the non-fiber group and the lowest labeling in the 5%-cellulose group might be due to the protective effects of cellulose.
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