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Original Article
- Gastrointestinal cancer
- Radiofrequency Ablation versus Stereotactic Body Radiation Therapy in the Treatment of Colorectal Cancer Liver Metastases
- Jesang Yu, Dong Hwan Kim, Jungbok Lee, Yong Moon Shin, Jong Hoon Kim, Sang Min Yoon, Jinhong Jung, Jin Cheon Kim, Chang Sik Yu, Seok-Byung Lim, In Ja Park, Tae Won Kim, Yong Sang Hong, Sun Young Kim, Jeong Eun Kim, Jin-hong Park, So Yeon Kim
- Cancer Res Treat. 2022;54(3):850-859. Published online October 13, 2021
- DOI: https://doi.org/10.4143/crt.2021.674
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Abstract
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Supplementary Material
PubReader
ePub - Purpose
This study aimed to compare the treatment outcomes of radiofrequency ablation (RFA) and stereotactic body radiation therapy (SBRT) for colorectal cancer liver metastases (CRLM) and to determine the favorable treatment modality according to tumor characteristics.
Materials and Methods
We retrospectively analyzed the records of 222 colorectal cancer patients with 330 CRLM who underwent RFA (268 tumors in 178 patients) or SBRT (62 tumors in 44 patients) between 2007 and 2014. Kaplan–Meier method and Cox models were used by adjusting with inverse probability of treatment weighting (IPTW).
Results
The median follow-up duration was 30.5 months. The median tumor size was significantly smaller in the RFA group than in the SBRT group (1.5 cm vs 2.3 cm, p<0.001). In IPTW-adjusted analysis, difference in treatment modality was not associated with significant differences in 1-year and 3-year recurrence-free survival (35% vs 43%, 22% vs 23%; p=0.198), overall survival (96% vs 91%, 58% vs 56%; p=0.508), and freedom from local progression (FFLP; 90% vs 72%, 78% vs 60%; p=0.106). Significant interaction effect between the treatment modality and tumor size was observed for FFLP (p=0.001). In IPTW-adjusted subgroup analysis of patients with tumor size >2 cm, the SBRT group had a higher FFLP compared with the RFA group (HR, 0.153; p<0.001).
Conclusion
SBRT and RFA showed similar local control in the treatment of patients with CRLM. Tumor size was an independent prognostic factor for local control and SBRT may be preferred for larger tumors. -
Citations
Citations to this article as recorded by
- Ablative techniques in colorectal liver metastases: A systematic review, descriptive summary of practice, and recommendations for optimal data reporting
Wee Han Ng, Catarina Machado, Alice Rooney, Robert Jones, Jonathan Rees, Samir Pathak
European Journal of Surgical Oncology.2025; 51(2): 109487. CrossRef - Effects of maximum dose on local control after stereotactic body radiotherapy for oligometastatic tumors of colorectal cancer
Su Jin Kang, Jongmoo Park, Gyu-Seog Choi, Jong Gwang Kim, Jun Seok Park, Hye Jin Kim, Jin Ho Baek, Byung Woog Kang, An Na Seo, Shin-Hyung Park, Bong Kyung Bae, Min Kyu Kang, Soo Yeun Park, Devarati Mitra
PLOS ONE.2025; 20(1): e0313438. CrossRef - Role of Radiotherapy in Liver Tumors: Recent Update
Vito Filbert Jayalie, Merinda, Herryanto Lumbantobing, Sudibio, Julius Oentario, Hendriyo, Sry Suryani Widjaja
Forum of Clinical Oncology.2025;[Epub] CrossRef - Treatment of Oligometastatic GI Cancers
Clayton T. Marcinak, Patrick B. Schwartz, Mustafa M. Basree, Newton Hurst, Michael Bassetti, Jeremy D. Kratz, Nataliya V. Uboha
American Society of Clinical Oncology Educational Book.2024;[Epub] CrossRef - Stereotactic radiotherapy for liver oligometastases: a pooled analysis following the estro/eortc consensus recommendations
D. Pezzulla, G. Chiloiro, E. M. Lima, G. Macchia, C. Romano, S. Reina, G. Panza, S. Cilla, A. G. Morganti, F. Cellini, M. A. Gambacorta, F. Deodato
Clinical & Experimental Metastasis.2024; 41(5): 667. CrossRef - Interventionelle Therapieoptionen bei oligometastasierten Tumoren
Max Seidensticker
Forum.2024; 39(5): 340. CrossRef - Efficacy and safety of B-ultrasound-guided radiofrequency ablation in the treatment of primary liver cancer: Systematic review and meta-analysis
Xiong Zhang, Hong-Yi Zhu, Ming Yuan
World Journal of Gastrointestinal Surgery.2024; 16(9): 2986. CrossRef - Analysis of alkaline phosphatase and γ-glutamyltransferase after radiofrequency ablation of primary liver cancer: A retrospective study
Wen-Yu Huang, Sheng Zheng, Dan Zhu, Ying-Lang Zeng, Juan Yang, Xue-Li Zeng, Pei Liu, Shun-Ling Zhang, Ming Yuan, Zhi-Xia Wang
World Journal of Gastrointestinal Surgery.2024; 16(9): 2860. CrossRef - Evidence-based clinical recommendations for hypofractionated radiotherapy: exploring efficacy and safety - Part 4: Liver and locally recurrent rectal cancer
Hwa Kyung Byun, Gyu Sang Yoo, Soo-Yoon Sung, Jin-Ho Song, Byoung Hyuck Kim, Yoo-Kang Kwak, Yeon Joo Kim, Yeon-Sil Kim, Kyung Su Kim
Radiation Oncology Journal.2024; 42(4): 247. CrossRef - Recent trends in radiotherapy use for major cancers in Korea
Kyungmi Yang, Jeong Eun Lee, Won Park, Yong Chan Ahn, Seung Jae Huh
Japanese Journal of Clinical Oncology.2023; 53(12): 1177. CrossRef - Combination of endoscopic ultrasound-guided radiofrequency ablation and adaptive radiation therapy for the treatment of lymph node metastases from colon adenocarcinoma: A case report
Federica Borrelli de Andreis, Maria Alessandra Calegari, Angela Romano, Maria Gabriella Brizi, Luigi Sofo, Ivo Boskoski, Guido Costamagna, Fabia Attili
Current Problems in Cancer: Case Reports.2023; 9: 100216. CrossRef - Comparison of radiofrequency ablation and ablative external radiotherapy for the treatment of intrahepatic malignancies: A hybrid meta-analysis
Chai Hong Rim, Jung Sue Lee, Soo Yeon Kim, Jinsil Seong
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Gyu Sang Yoo, Chai Hong Rim, Won Kyung Cho, Jae-Uk Jeong, Eui Kyu Chie, Hyeon-Min Cho, Jun Won Um, Yong Chan Ahn, Jong Hoon Lee
Cancer Research and Treatment.2023; 55(3): 707. CrossRef - Local Control Following Stereotactic Body Radiation Therapy for Liver Oligometastases: Lessons from a Quarter Century
Sara Mheid, Stefan Allen, Sylvia S. W. Ng, William A. Hall, Nina N. Sanford, Todd A. Aguilera, Ahmed M. Elamir, Rana Bahij, Martijn P. W. Intven, Ganesh Radhakrishna, Issa Mohamad, Jeremy De Leon, Hendrick Tan, Shirley Lewis, Cihan Gani, Teo Stanecu, Vero
Current Oncology.2023; 30(10): 9230. CrossRef - Evidence on percutaneous radiofrequency and microwave ablation for liver metastases over the last decade
Koji Tomita, Yusuke Matsui, Mayu Uka, Noriyuki Umakoshi, Takahiro Kawabata, Kazuaki Munetomo, Shoma Nagata, Toshihiro Iguchi, Takao Hiraki
Japanese Journal of Radiology.2022; 40(10): 1035. CrossRef
- Ablative techniques in colorectal liver metastases: A systematic review, descriptive summary of practice, and recommendations for optimal data reporting
- 9,647 View
- 305 Download
- 13 Web of Science
- 15 Crossref
Erratum
- ERRATUM: Prognostic Implications of Extranodal Extension in Relation to Colorectal Cancer Location
- Chan Wook Kim, Jihun Kim, Yangsoon Park, Dong-Hyung Cho, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
- Cancer Res Treat. 2021;53(3):893-893. Published online June 8, 2021
- DOI: https://doi.org/10.4143/crt.2018.392.E
- Corrects: Cancer Res Treat 2019;51(3):1135
- 3,799 View
- 70 Download
Original Articles
- Association of Body Composition with Long-Term Survival in Non-metastatic Rectal Cancer Patients
- Jin Soo Han, Hyoseon Ryu, In Ja Park, Kyung Won Kim, Yongbin Shin, Sun Ok Kim, Seok-Byung Lim, Chan Wook Kim, Yong Sik Yoon, Jong Lyul Lee, Chang Sik Yu, Jin Cheon Kim
- Cancer Res Treat. 2020;52(2):563-572. Published online December 3, 2019
- DOI: https://doi.org/10.4143/crt.2019.249
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Abstract
PDFPubReaderePub
- Purpose
We evaluated the association of body composition with long-term oncologic outcomes in non-metastatic rectal cancer patients.
Methods
We included 1,384 patients with stage(y)0-III rectal cancer treated at Asan Medical Center between January 2005 and December 2012. Body composition at diagnosis was measured using abdomino-pelvic computed tomography (CT). Sarcopenia, visceral obesity (VO), and sarcopenic obesity (SO) were defined using CT measured parameters such as skeletal muscle index (total abdominal muscle area, TAMA), visceral fat area (VFA), and VFA/TAMA. Inflammatory status was defined as a neutrophil-lymphocyte ratio of ≥3. Obesity was categorized by body mass index (≥ 25 kg/m2).
Results
Among the 1,384 patients, 944 (68.2%) had sarcopenia and 307 (22.2%) had SO. The 5-year overall survival (OS) rate was significantly lower in sarcopenic patients (no sarcopenia vs. sarcopenia; 84% vs. 78%, p=0.003) but the 5-year recurrence-free survival (RFS) rate was not different (77.3% vs. 77.9% p=0.957). Patients with SO showed lower 5-year OS (79.1% vs. 75.5% p=0.02) but no difference in 5-year RFS (p=0.957). Sarcopenia, SO, VO, and obesity were not associated with RFS. However, obesity, SO, age, sex, inflammatory status, and tumor stage were confirmed as independent factors associated with OS on multivariate analysis. In subgroup analysis, association of SO with OS was more prominent in patients with (y)p stage 0-2 and no inflammatory status.
Conclusion
The presence of SO and a low body mass index at diagnosis are negatively associated with OS in non-metastatic rectal cancer patients. -
Citations
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- 48 Web of Science
- 50 Crossref
- Prognostic Implications of Extranodal Extension in Relation to Colorectal Cancer Location
- Chan Wook Kim, Jihun Kim, Yangsoon Park, Dong-Hyung Cho, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
- Cancer Res Treat. 2019;51(3):1135-1143. Published online November 29, 2018
- DOI: https://doi.org/10.4143/crt.2018.392
- Correction in: Cancer Res Treat 2021;53(3):893
-
Abstract
PDFPubReaderePub
- Purpose
Extranodal extension (ENE) is closely associated with the aggressiveness of both colon and rectal cancer. This study evaluated the clinicopathologic significance and prognostic impact of ENE in separate populations of patients with colon and rectal cancers.
Materials and Methods
The medical records of 2,346 patients with colorectal cancer (CRC) who underwent curative surgery at our institution between January 2003 and December 2011 were clinically and histologically reviewed.
Results
ENE was associated with younger age, advanced tumor stage, lymphovascular invasion (LVI), and perineural invasion (PNI) in both colon and rectal cancer. ENE rates differed significantly in patients with right colon (36.9%), left colon (42.6%), and rectal (48.7%) cancers (right vs. left, p=0.037; left vs. rectum, p=0.009). The 5-year disease-free survival (DFS) rate according to ENE status and primary tumor site differed significantly in patients with ENE-negative colon cancer (80.5%), ENE-negative rectal cancer (77.4%), ENE-positive colon cancer (68.6%), and ENE-positive rectal cancer (64.2%) (p<0.001). Multivariate analysis showed that advanced tumor stage, ENE, LVI, PNI, and absence of adjuvant chemotherapy were independently prognostic of reduced DFS in colon and rectal cancer patients.
Conclusion
ENE is closely associated with the aggressiveness of colon and rectal cancers, with its frequency increasing from the right colon to the left colon to the rectum. ENE status is a significant independent predictor of DFS in CRC patients irrespective of tumor location. ENE might be more related with distally located CRC. -
Citations
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- Paired Primary and Metastatic Tumor Analysis of Somatic Mutations in Synchronous and Metachronous Colorectal Cancer
- Kyu-pyo Kim, Jeong-Eun Kim, Yong Sang Hong, Sung-Min Ahn, Sung Min Chun, Seung-Mo Hong, Se Jin Jang, Chang Sik Yu, Jin Cheon Kim, Tae Won Kim
- Cancer Res Treat. 2017;49(1):161-167. Published online July 4, 2016
- DOI: https://doi.org/10.4143/crt.2015.490
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Although the mutation status of KRAS is highly concordant in primary and metastatic lesions, it has not been generalized to other major pathway genes.
Materials and Methods
In this study, 41 genes were evaluated and the mutational profiles were compared in 46 colorectal cancer patients with paired surgical specimens of primary and metastatic lesions: synchronous (n=27) and metachronous (n=19) lesions. A high-throughput mass spectrometry-based genotyping platform validated by orthogonal chemistry, OncoMap v.4.4, was used to evaluate the formalin-fixed, paraffin-embedded surgical specimens. The patients’ demographics, tumor characteristics, and microsatellite instability status were analyzed by a retrospective chart review.
Results
In this study,with OncoMap, mutationswere identified in 80.4% of patientswith the following frequency: KRAS (39.1%), TP53 (28.3%), APC (28.3%), PIK3CA (6.5%), BRAF (6.5%), and NRAS (4.3%). Although 19.6% (9/46) of the patients showed no gene mutations, 43.5% (20/46) and 37.0% (17/46) had mutations in one and two or more genes, respectively. The synchronous and metachronous lesions showed similar mutational profiles. Paired samples between primary and metastatic tumors differed in 7.4% (2/27) and 10.5% (2/19) for synchronous and metachronous according to OncoMap.
Conclusion
These findings indicate the major pathway genes, including KRAS, TP53, APC, PIK3CA, BRAF, and NRAS, are often concordant between the primary and metastatic lesions regardless of the temporal relationship of metastasis. -
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- Preliminary Suggestion about Staging of Anorectal Malignant Melanoma May Be Used to Predict Prognosis
- Won Young Chae, Jong Lyul Lee, Dong-Hyung Cho, Chang Sik Yu, Jin Roh, Jin Cheon Kim
- Cancer Res Treat. 2016;48(1):240-249. Published online March 6, 2015
- DOI: https://doi.org/10.4143/crt.2014.305
-
Abstract
PDFPubReaderePub
- Purpose
Anorectal malignant melanomas (AMM) are rare and have poor survival. The study aims to evaluate the clinicopathologic characteristics and outcomes of patients with AMM, and to devise a staging system predictive of survival outcome.
Materials and Methods
This was a retrospective study of 28 patients diagnosed with, and treated for AMM. Patients classified by clinical staging of mucosal melanoma (MM) were reclassified via rectal and anal TNM staging. Survival outcomes were compared among patients grouped by the three different staging systems.
Results
The three staging systems were equated with similar figures for 5-year overall survival (OS) and 5-year disease-free survival (DFS) of patients diagnosed with stage I disease. Patients (n=19) diagnosed with MM stage II disease were reclassified by rectal TNM staging into three subgroups: IIIA, IIIB, and IIIC. For these patients, both 5-year OS and 5-year DFS differed significantly between the subgroups IIIA and IIIC (OS: IIIA vs. IIIC, 66.7% vs. 0%, p=0.002; DFS: IIIA vs. IIIC, 51.4% vs. 0%, p < 0.001).
Conclusion
The accuracy of prognosis in patients diagnosed with AMM and lymph node metastasis has improved by using rectal TNM staging, which includes information regarding the number of lymph node metastases. -
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Fan Zhang, Boqi Xu, Yao Peng, Runda Wu, Shan Tong, Zhongqi Mao
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Yu Du, Xiaona Chang, Xiangxiang Li, Shugang Xing
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Raluca Cristina Apostu, Elena Stefanescu, Radu Razvan Scurtu, Gabriel Kacso, Radu Drasovean
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Mireia Merichal Resina, Carlos Cerdan Santacruz, Enrique Sierra Grañón, Jordi Antoni Tarragona Foradada, Jorge Juan Olsina Kissler
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Correspondence
- Reply to Commentary on “Clinical Characteristics and Adequate Treatment of Familial Adenomatous Polyposis Combined with Desmoid Tumors”
- Jin Cheon Kim
- Cancer Res Treat. 2015;47(2):341-341. Published online February 26, 2015
- DOI: https://doi.org/10.4143/crt.2015.050
- 8,831 View
- 62 Download
Original Articles
- Clinical Characteristics and Adequate Treatment of Familial Adenomatous Polyposis Combined with Desmoid Tumors
- Won Beom Jung, Chan Wook Kim, Jin Cheon Kim
- Cancer Res Treat. 2014;46(4):366-373. Published online August 25, 2014
- DOI: https://doi.org/10.4143/crt.2013.185
-
Abstract
PDFPubReaderePub
- Purpose
The objective of this study was to examine the clincopathologic characteristics and outcomes of familial adenomatous polyposis (FAP) patients with and without desmoid tumors (DTs), including the risk factors for progression of FAP-related DTs. Materials and Methods We reviewed the medical records and database of all patients with FAP who were treated between January 1993 and December 2011. Results Of 75 FAP patients, 18 (24%) were FAP with DTs. Seventeen of these had intra-abdominal DTs and one had intra- and extra-abdominal DTs. We divided the patients into two groups according to type of resection; the R0 or R1 resection group, referred to as the curative resection group (eight patients), and the R2 resection/palliative operation/medical treatment group, referred to as the palliative resection group (10 patients). Two patients in the curative resection group and two patients in the palliative group had progressed to tumor growth by the follow-up (p=0.800). In univariate analysis, DT diagnosis before or simultaneously with FAP diagnosis (DTs unrelated to surgical trauma) was a significant risk factor for tumor progression at final follow-up. Conclusion A multidisciplinary approach to DT treatment is needed, including nonsteroidal antiinflammatory drugs, anti-estrogens, cytotoxic agents, and surgery. However, the role of surgery in resectable and complicated tumors may be limited. DT unrelated to surgical trauma has a relatively poor prognosis. -
Citations
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Surgical Oncology Insight.2024; 1(2): 100053. CrossRef - Adenomatous Polyposis Coli Gene Mutations, Risk Factors, and Long-term Outcomes Associated With Desmoid Tumors in Patients With Familial Adenomatous Polyposis After Colectomy in Japan
Tadahiro Kojima, Kiyotaka Kurachi, Moriya Iwaizumi, Kyota Tatsuta, Kosuke Sugiyama, Toshiya Akai, Mayu Sakata, Yoshifumi Morita, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Hiroya Takeuchi
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Edoardo Virgilio, Francesca Di Gregorio, Genoveffa Balducci
Cancer Research and Treatment.2015; 47(2): 339. CrossRef - Reply to Commentary on “Clinical Characteristics and Adequate Treatment of Familial Adenomatous Polyposis Combined with Desmoid Tumors”
Jin Cheon Kim
Cancer Research and Treatment.2015; 47(2): 341. CrossRef - Optimal therapy for desmoid tumors: current options and challenges for the future
Mushriq Al-Jazrawe, Magdalene Au, Benjamin Alman
Expert Review of Anticancer Therapy.2015; 15(12): 1443. CrossRef
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- Clinicopathologic Characteristics, Surgical Treatment and Outcomes for Splenic Flexure Colon Cancer
- Chan Wook Kim, Ui Sup Shin, Chang Sik Yu, Jin Cheon Kim
- Cancer Res Treat. 2010;42(2):69-76. Published online June 30, 2010
- DOI: https://doi.org/10.4143/crt.2010.42.2.69
-
Abstract
PDFPubReaderePub
Purpose This current study examined the clinicopathologic characteristics of patients with splenic flexure (SF) colon cancer and the association with the surgical outcomes to find the optimal procedure to treat this malady.
Materials and Methods A total of 167 operated patients with SF colon cancer were consecutively recruited between 1993 and 2003. The clinicopathological, operative and survival data was reviewed and analyzed.
Results For the SF colon cancer patients, the proportion of males was higher than that for the right-sided colon patients or the sigmoid-descending junction & sigmoid (SD & S) colon patients (p≤0.05, respectively) and the age at the time of diagnosis was younger (p≤0.05). Obstruction was more frequent in the patients with SF colon cancer than that for the patients with colon cancer at other sites (p≤0.001). The incidence of mucinous adenocarcinoma for the SF patients was similar to that for the patients with right-sided colon cancer, but it was higher than that for the patients with SD & S colon cancer (11.4% vs. 6.5%, p=0.248 or 2.5%, respectively, p=0.001). Disease-free and overall survival did not differ between the patients who underwent a left hemicolectomy and extended surgery such as combined splenectomy or subtotal colectomy. Multivariate analysis showed that old age (≥60 years) and a N1-2 and M1 status were the independent risk factors for overall survival.
Conclusion The SF colon cancers exhibited exclusively different characteristics as compared to colon cancers at other site colon cancers. It appears that left hemicolectomy was generally sufficient for a satisfactory oncological outcome, obviating concurrent splenectomy.
-
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G. Lisi, G. M. Garbarino, R. Del Giudice, D. Spoletini, M. Carlini
Colorectal Disease.2019; 21(9): 1090. CrossRef - Treatment of splenic flexure colon cancer: a comparison of three different surgical procedures: Experience of a high volume cancer center
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Scientific Reports.2019;[Epub] CrossRef - Intracorporeal Versus Extracorporeal Anastomosis for Laparoscopic Resection of the Splenic Flexure Colon Cancer: A Multicenter Propensity Score Analysis
Michele Grieco, Diletta Cassini, Domenico Spoletini, Enrica Soligo, Emanuela Grattarola, Gianandrea Baldazzi, Silvio Testa, Massimo Carlini
Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2019; 29(6): 483. CrossRef - Analysis of prognosis, genome, microbiome, and microbial metabolome in different sites of colorectal cancer
Yang Xi, Pan Yuefen, Wu Wei, Qi Quan, Zhuang Jing, Xu Jiamin, Han Shuwen
Journal of Translational Medicine.2019;[Epub] CrossRef - Subtotal colectomy versus left hemicolectomy for the elective treatment of splenic flexure colonic neoplasia
Marc Beisani, Francesc Vallribera, Albert García, Laura Mora, Sebastiano Biondo, Jaime Lopez-Borao, Ramon Farrés, Júlia Gil, Eloy Espin
The American Journal of Surgery.2018; 216(2): 251. CrossRef - Lymphatic Drainage of the Splenic Flexure Defined by Intraoperative Scintigraphic Mapping
Carolyn E. Vasey, Siraj Rajaratnam, Gregory O’Grady, Mike Hulme-Moir
Diseases of the Colon & Rectum.2018; 61(4): 441. CrossRef - Robotic left colectomy with complete mesocolectomy for splenic flexure and descending colon cancer, compared with a laparoscopic procedure
Jin Cheon Kim, Jong Lyul Lee, Yong Sik Yoon, Chan Wook Kim, In Ja Park, Seok‐Byeong Lim
The International Journal of Medical Robotics and Computer Assisted Surgery.2018;[Epub] CrossRef - Propensity score analysis of postoperative and oncological outcomes after surgical treatment for splenic flexure colon cancer
J. Martín Arévalo, D. Moro-Valdezate, S. A. García-Botello, V. Pla-Martí, M. Garcés-Albir, L. Pérez Santiago, A. Vargas-Durán, A. Espí-Macías
International Journal of Colorectal Disease.2018; 33(9): 1201. CrossRef - How we do it: totally laparoscopic complete mesocolon excision for splenic flexure cancer
Paolo Panaccio, Tommaso Grottola, Marco Ricciardiello, Pierluigi di Sebastiano, F. Francesco di Mola
Langenbeck's Archives of Surgery.2018; 403(6): 769. CrossRef - Long-term oncologic outcomes of laparoscopic surgery for splenic flexure colon cancer are comparable to conventional open surgery
Min Ki Kim, In Kyu Lee, Won-Kyung Kang, Hyeon-Min Cho, Bong-Hyeon Kye, Heba Essam Jalloun, Jun-Gi Kim
Annals of Surgical Treatment and Research.2017; 93(1): 35. CrossRef - Surgical Treatment of Colon Cancer of the Splenic Flexure: A Systematic Review and Meta-analysis
Aleix Martínez-Pérez, Francesco Brunetti, Giulio C. Vitali, Solafah Abdalla, Frédéric Ris, Nicola de’Angelis
Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2017; 27(5): 318. CrossRef - Laparoscopic extended right colectomy versus laparoscopic left colectomy for carcinoma of the splenic flexure: a matched case–control study
Nicola de’Angelis, Elisabeth Hain, Mara Disabato, Cristiana Cordun, Maria Clotilde Carra, Daniel Azoulay, Francesco Brunetti
International Journal of Colorectal Disease.2016; 31(3): 623. CrossRef - Laparoscopic resection of splenic flexure tumors
Massimo Carlini, Domenico Spoletini, Fabio Castaldi, Cristiano Giovannini, Umberto Passaro
Updates in Surgery.2016; 68(1): 77. CrossRef - Operative Method for Transverse Colon Carcinoma: Transverse Colectomy Versus Extended Colectomy
Choon Seng Chong, Jung Wook Huh, Bo Young Oh, Yoon Ah Park, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee
Diseases of the Colon & Rectum.2016; 59(7): 630. CrossRef - Optimum Level of Vessel Ligation in Splenic Flexure Cancer
Kim Nam Kyu
Journal of Surgery and Surgical Research.2016; : 055. CrossRef - Splenic flexure colon cancers: minimally invasive treatment
Valentino Fiscon, Giuseppe Portale, Giovanni Migliorini, Flavio Frigo
Updates in Surgery.2015; 67(1): 55. CrossRef - Laparoscopic colonic resection for splenic flexure cancer: our experience
Andrea Pisani Ceretti, Nirvana Maroni, Matteo Sacchi, Stefano Bona, Maria Rachele Angiolini, Paolo Bianchi, Enrico Opocher, Marco Montorsi
BMC Gastroenterology.2015;[Epub] CrossRef - The short- and long-term outcomes for patients with splenic flexure tumours treated by left versus extended right colectomy are comparable: a retrospective analysis
Manfred Odermatt, Najaf Siddiqi, Rose Johns, Danilo Miskovic, Omar Khan, Jim Khan, Amjad Parvaiz
Surgery Today.2014; 44(11): 2045. CrossRef - Elective subtotal colectomy with ileosigmoid anastomosis for colon cancer preserves bowel function and quality of life
G. Manceau, E. d'Annunzio, M. Karoui, S. Breton, G. Rousseau, A. S. Blanchet, J. C. Vaillant, L. Hannoun
Colorectal Disease.2013; 15(9): 1078. CrossRef - Totally laparoscopic resection of the splenic flexure for tumor
Francesco Roscio, Camillo Bertoglio, Antonio De Luca, Paolo Frattini, Federico Clerici, Ildo Scandroglio
Updates in Surgery.2012; 64(3): 185. CrossRef - Does the outcome of colonic flexure cancers differ from the other colonic sites?
Irshad A. Shaikh, Stuart A. Suttie, Mary Urquhart, Amin I. Amin, Thomas Daniel, Satheesh Yalamarthi
International Journal of Colorectal Disease.2012; 27(1): 89. CrossRef - Colon Cancer in the Splenic Flexure
Masayuki Nakashima, Takashi Akiyoshi, Masashi Ueno, Yosuke Fukunaga, Satoshi Nagayama, Yoshiya Fujimoto, Tsuyoshi Konishi, Rota Noaki, Keiko Yamakawa, Yasutomo Nagasue, Hiroya Kuroyanagi, Toshiharu Yamaguchi
Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2011; 21(6): 415. CrossRef
- Surgical approach to splenic flexure adenocarcinoma of the colon: Less is more?
- 12,877 View
- 98 Download
- 59 Crossref
- Optimal Timing for the Administration of Capecitabine with Preoperative Chemoradiation for Locally Advanced Rectal Cancer
- Young Ju Noh, Won Sik Choi, Jong Hoon Kim, Jin Cheon Kim, Chang Sik Yu, Hee Cheol Kim, Tae Won Kim, Heung Moon Chang, Min Hee Ryu, Seung Do Ahn, Sang-wook Lee, Seong Soo Shin, Jung Eun Lee, Eun Kyung Choi
- Cancer Res Treat. 2006;38(1):30-34. Published online February 28, 2006
- DOI: https://doi.org/10.4143/crt.2006.38.1.30
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Abstract
PDFPubReaderePub
Purpose Capecitabine is an oral fluoropyrimidine carbamate and it is known as an effective radiosensitizer. Capecitabine and its metabolite reach their peak concentration in the plasma at 1~2 hours after a single oral administration of capecitabine and the levels fall rapidly thereafter. To verify the radiosensitizing effect of capecitabine that is based on such pharmacokinetic characteristics, we performed a retrospective analysis on the optimal timing of capecitabine administration with performing preoperative chemoradiation for locally advanced rectal cancer.
Materials and Methods Among 171 patients who were treated with preoperative radiotherapy and concurrent capecitabine administration for rectal cancer, 56 patients were administered capecitabine at 1~2 hours before radiotherapy (group A), and at other time in the other 115 patients (group B). Total mesorectal excision was done at 4 to 6 weeks after the completion of chemoradiation. The radiosensitizing effect of capecitabine was evaluated on the basis of the pathological response.
Results Complete pathological regression of the primary tumor was observed in 12 patients (21.4%) for group A and in 11 patients (9.6%) for group B (p=0.031). Residual disease less than 0.5 cm (a good response) was observed in 19 patients (33.9%) for group A and in 23 patients (20.0%) for group B (p=0.038). On multivariate analysis, the capecitabine ingestion time showed marginal significance.
Conclusion When performing preoperative chemoradiation for locally advanced rectal cancer, the radiosensitizing effect of capecitabine was enhanced when it was administered 1 hour before radiotherapy.
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Citations
Citations to this article as recorded by- Systematic review of treatment intensification using novel agents for chemoradiotherapy in rectal cancer
R Clifford, N Govindarajah, J L Parsons, S Gollins, N P West, D Vimalachandran
British Journal of Surgery.2018; 105(12): 1553. CrossRef
- Systematic review of treatment intensification using novel agents for chemoradiotherapy in rectal cancer
- 9,423 View
- 50 Download
- 1 Crossref
Case Report
- Lymph Node Metastases of Prostatic Adenocarcinoma in the Mesorectum in Patients with Rectal Cancer
- In Ja Park, Hee Cheol Kim, Chang Sik Yu, Choung Soo Kim, Jung Sun Kim, Jin Cheon Kim
- Cancer Res Treat. 2005;37(2):129-132. Published online April 30, 2005
- DOI: https://doi.org/10.4143/crt.2005.37.2.129
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Abstract
PDFPubReaderePub
Lymph node involvement is the most important prognostic factor of rectal cancer. Cancer originating from sites other than the rectum rarely metastasizes to the mesorectal lymph node. We report a rectal cancer patient with a synchronous metastatic prostatic carcinoma to the mesorectal lymph node.
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Citations
Citations to this article as recorded by- A Case of Prostate Cancer Diagnosed by the Discovery of Pararectal Lymph Node Metastases during Sigmoid Colon Cancer Surgery
Daiki KATO, Chieko KITAMURA, Jun YAMADA
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2023; 84(9): 1515. CrossRef - A Case of Rectal Cancer with Lymph Node Metastasis of Prostate Cancer in the Mesorectum after Radical Prostatectomy
Teruhisa UDAGAWA, Yu SUZUKI, Yasushi ITO, Yoshihisa TAMATE, Naoki YANAGAWA, Takashi KAMEI
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2022; 83(4): 775. CrossRef - Two Cases of Colorectal Cancer with Mesenteric Lymph Node Metastasis Derived from Prostatic Cancer
Fumitaka Asahara, Hirotoshi Hasegawa, Shutaro Suda, Emima Bekku, Kazuhiko Hashimoto, Aya Sasaki, Junichi Matsui
The Japanese Journal of Gastroenterological Surgery.2020; 53(1): 61. CrossRef - Metastasization of mesorectal lymph nodes by a prostatic adenocarcinoma
J.J. Arenal, A. Torres, C. Tinoco, M.A. Citores, C. Benito, B. Madrigal, A. Vara
Human Pathology: Case Reports.2015; 2(2): 42. CrossRef
- A Case of Prostate Cancer Diagnosed by the Discovery of Pararectal Lymph Node Metastases during Sigmoid Colon Cancer Surgery
- 9,715 View
- 104 Download
- 4 Crossref
Original Articles
- Responsiveness of CPT-11 in Respect to hMLH1 and hMSH2 Protein Expression in the Primary Colorectal Cancer
- In Ja Park, Hee Cheol Kim, Chang Sik Yu, Heung Moon Chang, Jea Hwan Lee, Jong Hoon Kim, Tae Won Kim, Jung Sun Kim, Jin Cheon Kim
- Cancer Res Treat. 2004;36(6):360-366. Published online December 31, 2004
- DOI: https://doi.org/10.4143/crt.2004.36.6.360
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Abstract
PDFPubReaderePub
Purpose The aim of this study was to evaluate the responsiveness to CPT-11 with respect to hMLH1 and hMSH2 protein expressions in primary colorectal tumors.
Materials and Methods 91 patients with colorectal cancer treated having undergone surgery and postoperative CPT-11-based adjuvant chemotherapy, between 1997 and 2002, were prospectively recruited. Tumor samples were immunohistochemically analyzed for the expressions of hMLH1, hMSH2, p53 and CEA proteins.
Results Of the 91 tumors, 6 (6.6%) and 4 (4.4%) showed loss of hMLH1 and hMSH2 protein expressions, respectively. The response rate of patients with tumors not expressing either hMLH1 or hMSH2 was higher than that of those expressing either of these proteins (p=0.026). Patients with tumors not expressing hMLH1 showed a significantly better response to CPT-11 (p=0.04). The responsiveness was not associated with the expressions of hMSH2, p53 or CEA. There were no correlations between drug toxicity and the expressions of hMLH1, hMSH2 or p53. The overall survival was better in patients responsive to CPT-11-based chemotherapy compared to non-responders.
Conclusion The immunohistochemical determination of loss of hMLH1 and hMSH2 expressions may be used in determining the responsiveness to CPT-11-based chemotherapy. Our results suggest that hMLH1 protein expression may be a predictor for CPT-11 responsiveness in patients with colorectal cancer.
- 7,089 View
- 29 Download
- Prospective Phase II Study of Preoperative Chemoradiation with Capecitabine in Locally Advanced Rectal Cancer
- Jin-hong Park, Jong Hoon Kim, Seung Do Ahn, Sang-wook Lee, Seong Soo Shin, Jin Cheon Kim, Chang Sik Yu, Hee Cheol Kim, Yoon-Koo Kang, Tae Won Kim, Heung Moon Chang, Min Hee Ryu, Eun Kyung Choi
- Cancer Res Treat. 2004;36(6):354-359. Published online December 31, 2004
- DOI: https://doi.org/10.4143/crt.2004.36.6.354
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Abstract
PDFPubReaderePub
Purpose Capecitabine is an attractive oral chemotherapeutic agent that has a radiosensitizing effect and tumor-selectivity. This study was performed to evaluate the efficacy and toxicity of preoperative chemoradiation therapy, when used with oral capecitabine, for locally advanced rectal cancer.
Materials and Methods A prospective phase II trial of preoperative chemoradiation for locally advanced adenocarcinomas of the lower two-thirds of the rectum was conducted. A radiation dose of 50 Gy over five weeks and a daily dose of 1650 mg/m2 capecitabine in two potions was administered during the entire course of radiation therapy. Surgery was performed with standardized total mesorectal excision four to six weeks after completion of the chemoradiation.
Results Between January 2002 and September 2003, 61 patients were enrolled onto this prospective phase II trial. The pretreatment clinical stages were T3 in 64% (n=39), T4 in 36% (n=22) and N1-2 in 82% (n=50) of these patients. Fifty-six (92%) patients completed the chemoradiation as initially planned and a complete resection performed in 58 (95%). Down-staging was observed in 45 patients (74%) and a pathologic complete response in 6 (10%). Among the 37 patients with tumors located within 5 cm from the anal verge on colonoscopy, 27 (73%) underwent a sphincter-preserving procedure. No grade 3 and 4 proctitis or hematological toxicities were observed.
Conclusion Preoperative chemoradiation therapy with capecitabine achieved encouraging rates of tumor downstaging and sphincter preservation, with a low toxicity profile. This combined modality can be regarded as a safe and effective treatment for locally advanced rectal cancer.
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Citations
Citations to this article as recorded by- MRI for Rectal Cancer: Staging, mrCRM, EMVI, Lymph Node Staging and Post-Treatment Response
David D.B. Bates, Maria El Homsi, Kevin J. Chang, Neeraj Lalwani, Natally Horvat, Shannon P. Sheedy
Clinical Colorectal Cancer.2022; 21(1): 10. CrossRef - MRI of Rectal Cancer: An Overview and Update on Recent Advances
Kartik S. Jhaveri, Hooman Hosseini-Nik
American Journal of Roentgenology.2015; 205(1): W42. CrossRef - Current Controversies in Neoadjuvant Chemoradiation of Rectal Cancer
P. Terry Phang, Xiaodong Wang
Surgical Oncology Clinics of North America.2014; 23(1): 79. CrossRef - Tailored rectal cancer treatment – a time for implementing contemporary prognostic factors?
A. Wibe, W. L. Law, V. Fazio, C. P. Delaney
Colorectal Disease.2013; 15(11): 1333. CrossRef - Oncologic Outcome After Preoperative Chemoradiotherapy in Patients With Pathologic T0 (ypT0) Rectal Cancer
Tae Young Jang, Chang Sik Yu, Yong Sik Yoon, Seok-Byung Lim, Seung-Mo Hong, Tae Won Kim, Jong Hoon Kim, Jin Cheon Kim
Diseases of the Colon & Rectum.2012; 55(10): 1024. CrossRef - Phase II study of concurrent chemoradiotherapy with capecitabine and cisplatin in patients with locally advanced squamous cell carcinoma of the head and neck
J G Kim, S K Sohn, D H Kim, J H Baek, S B Jeon, Y S Chae, K B Lee, J S Park, J H Sohn, J C Kim, I K Park
British Journal of Cancer.2005; 93(10): 1117. CrossRef - Preoperative Concurrent Chemoradiotherapy with Oral Fluoropyrimidine in Locally Advanced Rectal Cancer: How Good Is Good Enough?
Hyun Cheol Chung
Cancer Research and Treatment.2004; 36(6): 341. CrossRef
- MRI for Rectal Cancer: Staging, mrCRM, EMVI, Lymph Node Staging and Post-Treatment Response
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- 53 Download
- 7 Crossref
Case Report
- Isolated Diaphragmatic Metastasis Originated from Adenocarcinoma of the Colon
- Kang Hong Lee, Chang Sik Yu, Hwan Namgung, Hee Cheol Kim, Jin Cheon Kim
- Cancer Res Treat. 2004;36(2):157-159. Published online April 30, 2004
- DOI: https://doi.org/10.4143/crt.2004.36.2.157
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Abstract
PDFPubReaderePub
Isolated diaphragmatic metastasis arising from colorectal cancer has been reported only one case in the literature presently. Here, we presented a new case and discussed the possible pathogenesis and the treatment options. A 42-year-old male patient had received anterior resection for sigmoid colon cancer. Although the increased serum CEA level was detected 20 months after the surgery, metastatic lesion could not be detected by repeated colonoscopy, CT scan, bone scan or PET scan for 35 months. We could detect a suspicious metastatic lesion on the liver by CT scan at 56 month after the surgery. During a second-look operation, we found a solitary metastasis on the diaphragm and removed it along with the 1 cm tumor-free resection margin. Although the prognosis associated with skeletal metastasis is poor, the complete resection of isolated diaphragmatic metastasis and subsequent appropriate adjuvant chemotherapy may achieve a cure the disease provided that other metastatic lesions are absent.
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Citations
Citations to this article as recorded by- Metastasis of endometrial cancer to right hemidiaphragm: A case report
Ivan Sergeevich Gruzdev, Ivan Andreevich Blokhin, Aleksey Nikolaevich Lednev, Aleksey Aleksandrovich Pechetov, Maksim Aleksandrovich Makov, Yuriy Sergeevich Esakov, Artem Garrievich Arevin, Andrey Vyacheslavovich Glotov, Grigory Grigorievich Kаrmаzаnovsky
International Journal of Surgery Case Reports.2019; 60: 363. CrossRef - Successful diagnosis of an occult fallopian tube carcinoma detected from the diaphragm metastasis
Takahide Toyoda, Hidemi Suzuki, Takahiro Nakajima, Takekazu Iwata, Ayumu Matsuoka, Kyoko Nishikimi, Yoko Yonemori, Makio Shozu, Yukio Nakatani, Ichiro Yoshino
General Thoracic and Cardiovascular Surgery.2018; 66(8): 484. CrossRef - A Rare Case of Diaphragmatic Mass: The Key to Diagnosis of a Lung Adenocarcinoma
Cláudia Rocha, Vera Clérigo, Lígia Fernandes, André Rodrigues, Dora Sargento, Glória Silva
Advances in Lung Cancer.2014; 03(03): 62. CrossRef - A Case Report of Diaphragmatic and Splenic Metastases from Descending Colon Cancer
Hiroaki FUJI, Yoshio KADOKAWA, Takafumi MACHIMOTO, Yoshito ASAO, Hiroaki FURUYAMA, Tsunehiro YOSHIMURA
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2014; 75(1): 128. CrossRef - A Case of a Solitaly Metastatic Diaphragmatic Tumor Resected from Rectal Cancer
Kazuhiro FUJII, Kunio KAMEDA, Yasuhiro SHIMIZU, Hidetaka SHIMA, Kentarou SEKIZAWA, Akira KUBO, Yoshinori TAKEKAWA
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2013; 74(10): 2829. CrossRef - A case of solitary diaphragmatic metastasis originating from a sigmoid colon cancer resected during thoracoscopic surgery
Kazuo MOTOYAMA, Kenta KOBAYASHI, Naoki ENOMOTO, Yoshihiro UEDA, Ryo OHNO
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2012; 73(5): 1080. CrossRef
- Metastasis of endometrial cancer to right hemidiaphragm: A case report
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- 60 Download
- 6 Crossref
Original Articles
- Patterns of Failure and Prognostic Factors in Anal Cancer Treated with Radiotherapy
- Kyoung Ju Kim, Jong Hoon Kim, Eun Kyung Choi, Seung Do Ahn, Sang Wook Lee, Jin Cheon Kim, Chang Sik Yu, Hee Cheol Kim, Je Hwan Lee, Tae Won Kim
- Cancer Res Treat. 2003;35(2):141-147. Published online April 30, 2003
- DOI: https://doi.org/10.4143/crt.2003.35.2.141
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Abstract
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- PURPOSE
To analyze the patterns of failure and prognostic factors affecting the local control and survivals in anal cancer treated with definitive radiotherapy, and to find the most effective treatment modality. MATERIALS AND METHODS: Thirty consecutive patients, with primary cancers of the anal canal, were treated using radiotherapy, both with and without 5-FU based concurrent chemotherapy. According to the AJCC tumor stage, six patients hadwere stage I, 11 had stage II, 2 had stage IIIA, and 11 had stage IIIB tumors. The median radiation dose was 45 Gy (30-72 Gy), and with 23 patients receivinged concurrent chemotherapy (5-FU and mitomycin C in 12 patients, 5-FU and cisplatin in 7, and other drugs in 4). The Mmedian follow up period was 43 months, (ranginge, from 8- to 99 months). RESULTS: Among the 1630 patients who16 were treated without surgical resection beforeprior to the radiotherapy, and a complete remission was observed in 12 patients (75%), a partial remission in 3 (19%), and a local progression in the other one patient. The Llocal failures, including persistent disease, were observed in 10 (33%), and the patients with higher T-stages (T3-4) had higher rates of local failure rates (T1-2, 21% vs. T3-4, 72%, p=0.03). Distant metastases were found in 4 patients (13%). The five year survival and disease free survival rates were 64% and 53%, respectively. The factors which affectinged the 5 year local relapse free survival were T-stage (74.9% in T1-2 vs. 28.6% in T3-4, p=0.01), and the existence of a gross tumor beforeprior to radiotherapy (84.6%, no residual vs. 45.1% with residual, p=0.03).
CONCLUSION
A Llocal recurrence was the major failure pattern in anal cancers, and the factors affecting a local failure were the T-stage and tumor volume beforeprior to radiotherapy. A Rradiation dose around 45 Gy was sufficient to control tumors of the earlier T stage tumors, but a higher dose should be considered for with more advanced lesions.
- 6,426 View
- 29 Download
- Somatic Mutations of APC Presenting Polymorphisms in the Hamartomatous Polyps of the Colon
- Jin Cheon Kim, Seon Ae Roh, Hee Cheol Kim, Chang Sik Yu, Nichoias E Beck, Walter F Bodmer
- J Korean Cancer Assoc. 1999;31(6):1288-1296.
- 2,178 View
- 13 Download
- In Vitro Chemosensitivity Test for the Evaluation of Efficiency of Hyperthermia in Gastrointestinal Cancer Cell Lines
- Jeong Hwan Yook, Byeong Yul Ahn, Geum Hee Koo, Hun Seo, Choon Sik Jeong, Sung Tae Oh, Byung Sik Kim, Kun Chun Park, Jin Cheon Kim
- J Korean Cancer Assoc. 1999;31(5):931-938.
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Abstract
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- PURPOSE
This study was designed to establish the experimental background of intra- peritoneal hyperthermo-chemotherapy in gastrointestinal cancer.
MATERIALS AND METHODS
We established stomach cancer cell lines; KATO-III, MKN45, AMC1 and colon cancer cell lines; AMC5, AMC6, CloneA, CCL188, C106, KM-12C. We performed chemosensitivity test by using MTT assay and calculated ICso of each chemotherapeutic agent. We confirmed antitumor effect of hyperthermia at 40C and 43C and antitumor synergistic effect with each chemotherapeutic agent at 40C and 43C.
RESULTS
The ICso was calculated in 7 (78%) of 9 cell lines for 5-FU, 6 (67%) for MMC, 5 (56%) for ADM, 1 (11%) for CDDP and VP-16. Antitumor effect of hyperthermia at 40C was not found, but, that at 43C was found except KATO-III and AMC6. In stomach cancer cell lines, antitumor synergistic effect of hyperthermia with anticancer drugs at 43C was found in VP-16 for MKN45 and KATO-III and in all of 5 drugs for AMC1. In colon cancer cell lines, this effect at 43C was found in all of 5 drugs for CCL188, in S-FU, CDDP, ADM for AMC5, in 5-FU, MMC, ADM, VP-16 for CloneA, KM-12C, and in 5-FU, CDDP, MMC, ADM for C106.
CONCLUSION
Hyperthermia itself had antitumor effect at 43C. Hyperthermo-chemotherapy had antitumor synergistic effect, especially at 43C.
- 2,599 View
- 21 Download
- Treatment of Hepatic Metastasis of Colorectal Cancer: A Retrospective Analysis of the Outcome in 99 Patients
- Jin Cheon Kim, Chang Nam Kim, Chang Sik Yu, Han Il Lee, Sang We Kim, Je Hwan Lee, Woo Kun Kim, Gyeong Hoon Kang, Moon Kyu Lee
- J Korean Cancer Assoc. 1998;30(6):1175-1183.
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Abstract
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- PURPOSE
Among various modalities of treatment in hepatic metastasis of colorectal cancer, hepatic resection has been proven to be the most effective treatment. This analysis was intended to determine important prognostic parameters and to understand clinically significant factors during hepatic resection and follow-up period in patients with hepatic metastasis from colorectal cancer.
MATERIALS AND METHODS
Among 1,022 colorectal cancer patients treated at Asan Medical Center from July 1989 to December 1995, 99 patients were found to have liver metastasis at the time of first diagnosis or during follow-up period. These 99 patients were the subject of analysis in this retrospective clinical study. Surgical resection with curative intent was done in 35 patients and chemotherapy in 46 patients. Eighteen patients were with no treatment or misssed during follow-up. Survival rate was analysed according to clinicopathological parameters: sex, age, location of primary tumor, preoperative serum CEA level, TNM staging of primary tumor, number of hepatic metastasis, distribution, synchronous or metachronous lesions, diesase free interval, mode of treatment, type of resection, tumor free resection margin.
RESULTS
Overall survival of the patients with hepatic metastasis was significantly related with numbers of metastasis (<4 vs. >4), distribution (unilobar vs. bilobar), synchronous or metachronous lesions, disease free interval ( < 12 vs. > 12 months), mode of treatment (hepatic resection vs. chemotherapy vs, no treatment, p<0.01. A multivariate analysis showed a significant association of survival with mode of treatment (p<0.01). Survival of patients with hepatic resection was significantly related with resection margin (positive vs. < 1 cm vs. > 1 cm), TNM staging of primary tumor (II vs. III), number of hepatic metastasis (p<0.01), disease free interval (p<0.05). A multivariate analysis showed a significant correlation with survival for tumor free resection margin (p<0.01).
CONCLUSION
An aggressive approach of hepatic resection in the colorectal liver metastasis will improve survival, if the lesion pennits. In patients with hepatic resection, tumor free resection margin was the most important prognostic parameter by the uniand multivariate analysis. Therefore, every effort should be made to ensure that the clear margin be kept at least more than 1 cm during hepatic resection.
- 2,872 View
- 14 Download
- Genomic Identification of N-Trminal Domail Exons of Carcinoembryonic Antigen in Human Colon Carcinoma
- Jin Cheon Kim, Sun Ae Noh, Kun Choon Park, In Kwon Jung
- J Korean Cancer Assoc. 1998;30(4):675-682.
- 2,214 View
- 12 Download
- Multiple Primary Malignant Neoplasm with Colorectal Cancer
- Hee Chul Kim, Chang Nam Kim, Chun Sik Jung, Chang Sik Yu, Jin Cheon Kim
- J Korean Cancer Assoc. 1998;30(4):668-674.
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Abstract
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- PURPOSE
The incidence of multiple primary malignant neoplasm has increased in recent decades. The etiologies and epidemiologies of multiple primary malignant neoplasm are still remained to be verified. A group of patients with multiple primary malignant neoplasms accompanied by colorectal cancer was analyzed to determine the relationship between certain cancers and colorectal cancer.
MATERIALS AND METHODS
From Jan. 1989 to Jun 1997, there were 56 patients with colorectal cancers accompanied by cancers of another organs. The retrospective analysis was done on the basis of cancer origin and intervals between the cancers.
RESULTS
The male-to-female ratio was 25 to 31. The characteristics of colorectal cancers in multiple primary malignant neoplasm were similar to the colorectal cancers without other cancers. Among 56 patients, 50 patients had the double primaries and 6 had the triple primaries. In the patients with double primaries, extracolonic cancers were found in the stomach(16), hepatobiliary system(12), urologic system(6), gynecologic organ(6) and others. In the patients with triple primaries, extracolic cancers were found in the stomach(5), uterus(2), lung(2) and others. The patients with family history of malignancy were 10 cases and the rate in the triple primaries seemed to be higher than double primaries.
CONCLUSION
It could be desirable to follow-up and work-up the patients with colorectal cancer keeping in mind that the malignancy in other organs especially stomach might be present.
- 2,490 View
- 14 Download
- Primary Signet Ring Cell Carcinoma of the Colon and Rectum
- Hee Chul Kim, Chang Nam Kim, Choon Sik Jeong, Chang Sik Yu, Byung Sik Kim, Hun Kyung Lee, Jin Cheon Kim
- J Korean Cancer Assoc. 1998;30(3):521-526.
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Abstract
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- PURPOSE
Signet ring cell carcinoma is a rare type of adenocarcinoma in the colon and rectum. We evaluated the differences of clinical features between colorectal signet ring cell carcinoma and ordinary adenocarcinoma.
MATERIALS AND METHODS
The clincopathologic data of 13 cases with primary colorectal signet ring cell carcinoma were reviewed. The primary colorectal signet ring cell carcinoma was diagnosed when following criteria were met: 1) the tumor was primary; 2) histologic material was adequate; 3) signet ring cells represented more than 50% of the cancer.
RESULTS
Patients ranged in age from 20 to 68 (median, 45) years; 7 were male, and 6 were female. Three tumors were located in the proximal colon, 3 in the distal colon, and 7 in the rectum. There was no case that had family history. Most cases (77%) were stage III, one was stage II, and two were stage IV with peritoneal seeding. There were 9 cases that showed local recurrence or distant metastases during follow-up periods 6 cases with peritoneal seeding, 3 with bone metastases, 2 with brain metastases and 1 with pelvic recurrence (two cases had either bone and brain metastasis, and one case had bone and peritoneal seeding). Prognosis was extremely poor, and overall two years survival rate was 25%. CONCLUSION: Early onset, mode of metastasis and poor prognosis may imply the different biologic behavior of signet ring cell carcinoma, compared with ordinary adenocarcinoma. To improve outcome, early diagnosis and radical operation should be stressed.
- 4,716 View
- 97 Download
- Microvessel Count and Overexpression of p53 in Early Colorectal Cancer
- Young Min Kim, Gyeong Hoon Kang, Suk Kyun Yang, Chang Sik Yu, Jin Cheon Kim
- J Korean Cancer Assoc. 1998;30(1):80-88.
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Abstract
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- PURPOSE
Angiogenesis, playing a critical role in tumor growth, development, and metastatic process, is alleged to be related to the prognostic factors and patient's survival of the colo-rectal cancer. The p53 gene, present in short arm of chromosome 17, is involved in multistep colo-rectal carcinogenesis. The correlation of p53 gene and angiogenesis has been recently reported. So, we designed to assess (1) the rate of p53 overexpression, (2) the prognostic significance of microvessel count, and (3) the relationship of p53 overexpression and angiogenesis in early colo-rectal cancer(ECC) patients. MATERIAL AND METHODS: The study material included 68 ECC from 65 patients, 40 mucosal (m-ECC) and 28 submucosal ECCs (sm-ECC). Immunostainings against p53 and factor VIII-related antigen were done and the results were analyzed with respect to tumor depth, site, and differentiation. And also the correlation between p53 overexpression and microvessel counts(MVC) was performed.
RESULT
The rate of p53 overexpression was higher in sm-ECC than in m-ECC (p < 0.05). The rate of p53 overexpression was highest in sigmoid colon and statistically significantly different compared with other sites. The differentiation of the tumor was closely correlated with p53 overexpression and the poorer the differentiation, the more overexpression of p53 (p<0.05). There was no significant difference between MVCs of m-ECC and sm-ECC (27.2+/-5.5 and 29.8 +/-6.0,respectively). However, MVC were higher in sigmoid colon than in any other sites (p<0.05). MVC did not show significant correlation with tumor differentiation or p53 overexpression.
CONCLUSION
These data indicate that p53 overexpression is correlated with tumor depth and differentiation but not MVC. The significance of higher MVC and p53 overexpression in sigmoid colon are reserved for further studies.
- 2,537 View
- 13 Download
- A Case of the Pancreatic Pseudocyst due to Metastatic Malignant Melanoma
- Bong Soo Chung, Jin Cheon Kim, Chang Sik Yu, Han Il Lee, Chang Nam Kim, Duck Jong Han, Gyeong Hoon Kang
- J Korean Cancer Assoc. 1997;29(3):528-533.
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Abstract
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- Malignant melanoma constitutes approximately 1% of all cancer (1,2). As the biologic behavior seems to be unpredictable, variation in the metastatic spread are not infrequently met. The common sites of metastasis are lymph nodes, lung, liver, brain, bone, heart, adrenal glands, and gastrointestinal tract in descending order (2). However multiple organ involvement is a common feature at the advanced stage. A 38-year-old male had developed pancreatic pseudocyst during the course of malignant melanoma at right sole. It was proven to be from matastatic malignant melanoma.
- 2,693 View
- 16 Download
- Hepatic Intraarterial Chemotherapy in Unresectable Hepatic Metastases of Colorectal Cancer
- Jin Cheon Kim, Han Il Lee, Chang Sik Yu, Hee Won Chung, Sang Wee Kim, Jeong Sin Lee, Kun Choon Park
- J Korean Cancer Assoc. 1997;29(2):227-234.
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Abstract
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- PURPOSE
Unresectable hepatic metastases of colorectal cancer does not seem to be amenable to the various treatment modalities. We modified hepatic intraarterial chemotherapy by different installation of port and regimen.
MATERIALS AND METHODS
Between July 1989 to December 1995, 27 patients of colorectal cancer with unresectable liver metastases were randomly allocated into either hepatic intraarterial (HA, 11 patients) or systemic intravenous (IV, 16 patients) chemotherapy after primary tumor resection. Chemo-port was installed with preservation of hepatic arterial flow. One cycle of HA regimen included 5-fluorouracil (5-FU) and mitomycin-C (MMC) with or without leucovorin (LV) for 14 days every month. The IV regimen included 5-FU and LV for 5 days every month. Both HA and IV chemotherapy were continued from 6 to 12 cycles.
RESULTS
The response exceeding partial remission was experienced in six patients (55%) among 11 patients in the HA group, while only two (13%) patients showed response among sixteen patients in the IV group. One year survival was not different between two groups. Although lethal toxicity was not found, patients showed marked increase of the performance scale (ECOG) in both groups.
CONCLUSION
Although survival benefit was not prominent, higher response rate with tolerable complication was found in the HA group. Prudent selection of effective drugs and combination of systemic chemotherapy are needed to improve the survival with minimal complication.
- 2,784 View
- 14 Download
- Changes of serum carcinoembryonic antigen in patients with colorectal cancer
- Jin Cheon Kim, Dae Yong Hwang, Byung Sik Kim, Young Il Min, Myung Hae Lee, Kun Choon Park
- J Korean Cancer Assoc. 1992;24(6):880-884.
- 2,796 View
- 14 Download
- Applicability of DMH-induced colorectal tumor model in respect to carcinogenesis
- Jin Cheon Kim, Gyeong Yeop Gong, Kyoo Yeon Park, Byung Sik Kim, Kun Choon Park, In Chul Lee
- J Korean Cancer Assoc. 1992;24(2):239-248.
- 2,337 View
- 13 Download
- Initial results of adenoma culture for adenoma-carcinoma continuum in the colorectal tumor
- Jin Cheon Kim, Kyoo Yeon Park, Kun Choon Park, Jae Dam Lee
- J Korean Cancer Assoc. 1992;24(2):218-226.
- 2,197 View
- 13 Download
- Consecutive DNA measurements in synchronous colorectal adenoma and adenocarcinoma
- Jin Cheon Kim, Gyoung Yeop Gong, Kun Choon Park, Suk Koo Kim, Jin Hyang Park, In Chul Lee
- J Korean Cancer Assoc. 1991;23(4):693-700.
- 2,112 View
- 13 Download
- Perineal pagent's disease involving the inguinoscrotal area
- Jin Cheon Kim, Kun Choon Park, Kyung Suck Koh, Eun Sil Yu, Kyung Jeh Sung
- J Korean Cancer Assoc. 1991;23(2):465-469.
- 2,137 View
- 14 Download
- An Autoradiographic Study on the Progress of 1 , 2-Dimethylhydrazine - Induced Colonic Carcinogenesis in Rats
- Jin Cheon Kim, Hye Sung Lee
- J Korean Cancer Assoc. 1989;21(2):317-328.
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Abstract
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- 1,2-dimethylhydrazine induced colonic carcinogenesis was performed to examine colsely the preneoplastic changes and progress of colonic carcinoma in rats. Rats were grouped into 5 by differences of chow in their properties of cellulose-composition. For the purpose of reducing the artificial errors, the metabvlic and energy balances among groups were homogenized by the control of metabolic energy and fixation of several nutrients of chow significantly affecting colonic carcinogenesis. At the same time, low-dose and high-frequency injection of DMH was applied for the approximation of natural carcinogenesis. The results were analysed by autoradiography using tritiated thymidine on 18 weeks after start of l)K1H-injection. As compared to the controi, 2 to 27 fold-increase of crypt height, labeled cells, and labeling index were identified in the l)MH-injected. The loss of body weight as well as these findings of significant increase in hyperplastic celis should reveal the preneoplastic changes during that period. Among the cloinic segments, the labeling results showed the highest in the ascending colon and it coincided with thc highest incidence of adenocarcinomn in the same segment. The distributing pattern of labeled cells showed that the lower 1/3 predominated over the middle and upper 1/3 with significant difference, in other words. downward migratory pattern was found. De novo formation rif colonic carcinoma in DMH-induced culonic carcinogenesis in rats was highly suspected clue tv clownward migratory pattern of labeled cells and no adenoma-carcinoma sequence in uur histopathologic results. Incidcnce of colonic adenocarcinoma reduced significantly in the group fed on 20%-cellulose containing group compared to the non-fiber group and the lowest labeling in the 5%-cellulose group might be due to the protective effects of cellulose.
- 2,587 View
- 14 Download
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