Cancer Research and Treatment

Original Article

Clinicopathological Features of Low-Grade Thyroid-like Nasopharyngeal Papillary Adenocarcinoma: Minhua Li, Jiangguo Wei, Xiaofei Yao, Cheng Wang; Cancer Res Treat. 2017;49(1):213-218. Published online July 4, 2016; DOI: https://doi.org/10.4143/crt.2016.195

Purpose
Primary low-grade thyroid-like papillary adenocarcinomas are extremely rare neoplasms that generally originate in the nasopharynx. Here, we describe a novel case of a 15-year-old Chinese girl who was diagnosed with low-grade thyroid-like papillary adenocarcinoma, including a brief review of the literature to reveal the clinicopathological features of low-grade thyroid-like nasopharyngeal papillary adenocarcinoma.
Materials and Methods
Immunohistochemistry was used to evaluate the expression of pan-cytokeratin (CKpan), cytokeratin (CK) 7, thyroid transcription factor 1 (TTF-1), vimentin, epithelial membrane antigen (EMA), thyroglobulin, CD15, S100, P40, CK20, CDX-2, glial fibrillary acidic protein (GFAP), and Ki-67. Additionally, in situ hybridization investigation was utilized to identify the presence of small Epstein-Barr virus (EBV)–encoded RNA.
Results
Histopathological analysis revealed florid proliferation of papillary structures lined by columnar epithelial cells with fibrovascular cores. Immunohistochemically, the neoplastic cells were positive for CKpan, CK7, TTF-1, vimentin, and EMA, but negative for thyroglobulin, CD15, S100, P40, CK20, CDX-2, and GFAP. The Ki-67–labeling index reached 5% in the most concentrated spot. In situ hybridization for EBV was negative.
Conclusion
Due to the distinct rarity of low-grade thyroid-like papillary adenocarcinomaswith a favorable clinical outcome, a nationwide effort to raise public awareness of this neoplasm is required.

Citations

Citations to this article as recorded by

Clinicopathologic features of thyroid-like low-grade nasopharyngeal papillary adenocarcinoma
Weiwei Chen, Jing Zhao
Asian Journal of Surgery.2024; 47(5): 2433. CrossRef
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: a clinicopathological and molecular study of four cases
Lei Wang, Xiao-tong Wang, Yuan Fang, Wei Qiu, Qiu-yuan Xia, Ru Fang, Qiu Rao, Hong-lin Yin
Human Pathology.2023; 134: 66. CrossRef
Epstein–Barr virus-associated poorly differentiated nasopharyngeal adenocarcinoma: a case report and literature review
Shuai Zhang, Xiao-Peng Huang, Hai-Hong Li, Ze-Tan Chen
Journal of International Medical Research.2023;[Epub] CrossRef
Nasopharyngeal Papillary Adenocarcinoma: A Cotton Swab Appearance on Computer Tomography
Jae-Hoon Lee, Jung-Hun Kown
Ear, Nose & Throat Journal.2022; 101(1): NP28. CrossRef
Cribriform adenocarcinoma of minor salivary glands presented as a nasopharyngeal tumor: A case report highlighting the significance of cytology
Olga Kuczkiewicz-Siemion, Emilia Wnuk, Monika Durzyńska
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2022; 133(4): e91. CrossRef
Genetic profile identification and clinicopathologic characteristics analysis of the thyroid-like low-grade nasopharyngeal papillary adenocarcinoma
Tiansheng Wang, Xinrong Liu, Wentao Yu, Lin Gao, Wenzhi Deng, Qiongzhi He, Feifei Liao, Ling Chu
Pathology - Research and Practice.2022; 236: 153980. CrossRef
A Rare Case of Low-grade Nasopharyngeal Papillary Adenocarcinoma in a Young Adult Woman
Yasir Nuhu Jibril, Abubakar Danjuma Salisu, Muhammad Inuwa Mustapha, Olatunde Olaniyi Abiodun Oluwafemi
Journal of West African College of Surgeons.2022; 12(1): 107. CrossRef
Endoscopic Low-Temperature Plasma Radiofrequency Ablation for Primary Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma
Qing-Yao Zhong, Qiang Sun, Zhao-Hui Liu
Ear, Nose & Throat Journal.2021; 100(7): 563. CrossRef
A novel low‐grade nasopharyngeal adenocarcinoma characterized by a GOLGB1‐BRAF fusion gene
Justin Bubola, Cristina R. Antonescu, Ilan Weinreb, David Swanson, John R. De Almeida, Christina M. MacMillan, Brendan C. Dickson
Genes, Chromosomes and Cancer.2021; 60(1): 49. CrossRef
Low-Grade Nasopharyngeal Papillary Adenocarcinoma: A Review of 28 Patients in a Single Institution
Yuting Lai, Wanpeng Li, Changwen Zhai, Xiaole Song, Jingyi Yang, Xicai Sun, Dehui Wang
Cancer Management and Research.2021; Volume 13: 1271. CrossRef
Patología del tabique nasal (a excepción de la desviación septal)
D. Malinvaud, P. Bonfils
EMC - Otorrinolaringología.2021; 50(3): 1. CrossRef
Patologia del setto nasale (deviazione del setto esclusa)
D. Malinvaud, P. Bonfils
EMC - Otorinolaringoiatria.2021; 20(3): 1. CrossRef
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma with squamous differentiation in the posterior nasal septum
Li Yi, Honglei Liu
Medicine.2021; 100(51): e28349. CrossRef
A Case of Thyroid-like Low Grade Nasopharyngeal Papillary Adenocarcinoma of the Posterior Nasal Septum
Arisa Oguchi, Takumi Kumai, Kan Kishibe, Miki Takahara, Akihiro Katada, Tatsuya Hayashi, Yasuaki Harabuchi
Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology).2021; 60(4): 495. CrossRef
Pathologie du septum nasal (déviation septale exclue)
D. Malinvaud, P. Bonfils
EMC - Oto-rhino-laryngologie.2021; 36(2): 1. CrossRef
Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma with Biphasic Histology
Rusella Mirza, Nestor Dela Cruz, Guillermo A. Herrera
Case Reports in Pathology.2020; 2020: 1. CrossRef
Primary papillary epithelial tumour of the sella: expanding the spectrum of TTF‐1‐positive sellar lesions
F. Roncaroli, D. Chatterjee, C. Giannini, M. Pereira, S. La Rosa, J. P. Brouland, K. Gnanalingham, C. Galli, B. Fernandes, A. Lania, B. Radotra
Neuropathology and Applied Neurobiology.2020; 46(5): 493. CrossRef
Primary thyroid-like low-grade nasopharyngeal papillary adenocarcinoma in a 11-year-old male patient: The first case report in Indonesia
Emilia Theresia, Ery Kus Dwianingsih, Hanggoro Tri Rinonce, Rita Cempaka, Camelia Herdini, Irianiwati
Human Pathology: Case Reports.2020; 21: 200392. CrossRef
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma
Li Maocai, Liu Fuxing, Li Lianqing, Gong Lili, Duan WenChao, Liu ShouZhou
Medicine.2020; 99(33): e21599. CrossRef
A Case of Low Grade Thyroid Like Nasopharyngeal Papillary Adenocarcinoma in Posterior Nasal Septum
Chang Lok Ji, Geun Hyung Park, Soo Kweon Koo, Hwaseon Lee
Journal of Clinical Otolaryngology Head and Neck Surgery.2020; 31(1): 70. CrossRef
Biphasic Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma with a Prominent Spindle Cell Component: A Case Report
Sang Hwa Lee, Hyunjin Kim, Min Ju Kim, Byungwha Kim, Hyun-Soo Kim
Diagnostics.2020; 10(5): 323. CrossRef
Clinicopathological Features of Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma: A Case Report and Review of the Literature
Hiromasa Takakura, Takeru Hamashima, Hirohiko Tachino, Akira Nakazato, Hiroshi Minato, Masakiyo Sasahara, Hideo Shojaku
Frontiers in Surgery.2020;[Epub] CrossRef
Nasopharyngeal Papillary Adenocarcinoma as a Second Head and Neck Malignancy
Aanchal Kakkar, Pirabu Sakthivel, Swati Mahajan, Alok Thakar
Head and Neck Pathology.2019; 13(4): 699. CrossRef
Thyroid-like low-grade papillary adenocarcinoma of nasopharynx
Ainaz Sourati, Mona Malekzadeh, Azadeh Rakhshan
BMJ Case Reports.2019; 12(6): e226949. CrossRef
Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma
Fengbo Huang, Xueping Xiang, Bo Hong, Jie Min, Jinfan Li
American Journal of Clinical Pathology.2019; 152(5): 582. CrossRef
Progressive Bilateral Nasal Obstruction Due to Nasopharyngeal Mass
Hyun Jin Min, Kyung Soo Kim
JAMA Otolaryngology–Head & Neck Surgery.2019; 145(10): 971. CrossRef
Clinicopathologic Characteristics of Thyroid-like Low-grade Nasopharyngeal Papillary Adenocarcinoma: A Case Report
Liang Li, Fengjuan Zhou, Fanzhong Lin, Cuihong Han
Applied Immunohistochemistry & Molecular Morphology.2019; 27(8): e81. CrossRef
The specific immunophenotypic features of nasopharyngeal carcinoma
G. A. Demyashkin, I. V. Kastyro, A. V. Sidorin, Ya. S. Borisov
Vestnik otorinolaringologii.2018; 83(5): 40. CrossRef
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma with squamous differentiation: a novel histological finding
Takashi Oide, Osamu Kadosono, Jun Matsushima, Di Wu, Hiroaki Nagashima, Hideto Saigusa, Atsuko Masunaga, Yukio Nakatani, Kenzo Hiroshima
Human Pathology.2017; 70: 43. CrossRef
Primary thyroid-like low-grade nasopharyngeal papillary adenocarcinoma
Wan-Lin Zhang, Shuang Ma, Lauren Havrilla, Lin Cai, Cheng-Qian Yu, Shuai Shen, Hong-Tao Xu, Liang Wang, Juan-Han Yu, Xu-Yong Lin, Endi Wang, Lian-He Yang
Medicine.2017; 96(47): e8851. CrossRef

11,733 View
241 Download
29 Web of Science
30 Crossref

First
Prev
Page of 1
Next
Last

Search