Cancer Research and Treatment

Original Articles

Gastrointestinal Cancer

Double Tract Reconstruction Reduces Reflux Esophagitis and Improves Quality of Life after Radical Proximal Gastrectomy for Patients with Upper Gastric or Esophagogastric Adenocarcinoma: Xin Ji, Chenggen Jin, Ke Ji, Ji Zhang, Xiaojiang Wu, Ziyu Jia, Zhaode Bu, Jiafu Ji; Cancer Res Treat. 2021;53(3):784-794. Published online December 29, 2020; DOI: https://doi.org/10.4143/crt.2020.1064

Purpose
The aim of the present study was to compare the difference between double tract reconstruction and esophagogastrostomy.
Materials and Methods
Patients who underwent radical proximal gastrectomy with esophagogastrostomy or double tract reconstruction were included in this study.
Results
Sixty-four patients were included in this study and divided into two groups according to reconstruction method. The two groups were well balanced in perioperative safety and 3-year overall survival (OS). The rates of postoperative reflux esophagitis in the double tract reconstruction group and esophagogastrostomy group were 8.0% and 30.8%, respectively (p=0.032). Patients in the double tract reconstruction group had a better global health status (p < 0.001) and emotional functioning (p < 0.001), and complained less about nausea and vomiting (p < 0.001), pain (p=0.039), insomnia (p=0.003), and appetite loss (p < 0.001) based on the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire. Regarding the EORTC QLQ-STO22 questionnaire, patients in the double tract reconstruction group complained less about dysphagia (p=0.030), pain (p=0.008), reflux (p < 0.001), eating (p < 0.001), anxiety (p < 0.001), dry mouth (p=0.007), and taste (p=0.001). The multiple linear regression analysis showed that reconstruction method, postoperative complications, reflux esophagitis, and operation duration had a linear relationship with the global health status score.
Conclusion
Double tract reconstruction could better prevent reflux esophagitis and improve quality of life without scarifying perioperative safety or 3-year OS.

Citations

Citations to this article as recorded by

Function Preserving Gastrectomy and Quality of Life
Jeesun Kim, Hyuk-Joon Lee
Journal of Gastric Cancer.2025; 25(1): 247. CrossRef
Comparative study of clinical efficacy of laparoscopic proximal gastrectomy with double-channel anastomosis and tubular gastroesophageal anastomosis
Mian Wang, Li-Li Zhang, Gang Wang, Yong-Chang Miao, Tao Zhang, Lei Qiu, Gui-Da Fang, Feng Lu, Da-Lai Xu, Peng Yu
World Journal of Gastrointestinal Surgery.2025;[Epub] CrossRef
Comparison of the efficacy, safety and postoperative quality of life between modified side overlap anastomosis and double-tract anastomosis after laparoscopic proximal gastrectomy
Chu-Ying Wu, Wen-Jin Zhong, Kai Ye
Updates in Surgery.2024; 76(6): 2255. CrossRef
Study of Short-Term and Long-Term Outcomes Between Esophagogastrostomy and Double-Tract Reconstruction After Proximal Gastrectomy
Tsuyoshi Hasegawa, Naoshi Kubo, Katsunobu Sakurai, Junya Nishimura, Yasuhito Iseki, Takafumi Nishii, Sadatoshi Shimizu, Toru Inoue, Yukio Nishiguchi, Kiyoshi Maeda
Journal of Gastrointestinal Cancer.2024; 55(3): 1089. CrossRef
Comparative analysis of two digestive tract reconstruction methods in total laparoscopic radical total gastrectomy
Tian-Xiang Dong, Dong Wang, Qun Zhao, Zhi-Dong Zhang, Xue-Feng Zhao, Bi-Bo Tan, Yu Liu, Qing-Wei Liu, Pei-Gang Yang, Ping-An Ding, Tao Zheng, Yong Li, Zi-Jing Liu
World Journal of Gastrointestinal Surgery.2024; 16(4): 1109. CrossRef
Differences in glycemic trends due to reconstruction methods after proximal gastrectomy from the perspective of continuous glucose-monitoring
Katsutoshi Shoda, Takeshi Kubota, Yoshihiko Kawaguchi, Hidenori Akaike, Suguru Maruyama, Yudai Higuchi, Takashi Nakayama, Ryo Saito, Koichi Takiguchi, Shinji Furuya, Kensuke Shiraishi, Hidetake Amemiya, Hiromichi Kawaida, Daisuke Ichikawa
Surgery Today.2024; 54(9): 1104. CrossRef
The Short‐Term and Long‐Term Outcomes of Laparoscopy‐Assisted Proximal Gastrectomy with Double‐Tract Reconstruction versus Laparoscopy‐Assisted Total Gastrectomy with Roux‐en‐Y Reconstruction for Adenocarcinoma of the Esophagogastric Junction: A Multicent
Zhiwen Xu, Wei Lin, Su Yan, Shaoqin Chen, Jinping Chen, Qingqi Hong, Hexin Lin, Liangbin Xiao, Jingtao Zhu, Haoyu Bai, Xuejun Yu, Jun You, Eiji Sakai
Gastroenterology Research and Practice.2024;[Epub] CrossRef
Double tract reconstruction improves the quality of life and better maintain the BMI of patients with proximal gastric cancer
Zi jian Wang, Zi yao Xu, Zi jie Huang, Li Li, Da Guan, Yun he Gao, Xin xin Wang
BMC Surgery.2024;[Epub] CrossRef
Short-term outcomes and quality of life of esophagogastrostomy versus the double-tract reconstruction after laparoscopic proximal gastrectomy
Yong Sun, Chao Chen, Lei Hou, Enhong Zhao
BMC Cancer.2024;[Epub] CrossRef
Uncut interposed jejunum pouch versus esophago-gastrostomy and double anastomoses of jejunum to the esophagus and residual stomach: An innovative method of digestive tract reconstruction following proximal gastrectomy
JiaQing Gong, Xia Liu, GuangLan Wang, Wei Li, GuoDe Luo, Yan Lin, Bin Zhang, ChuanDong Chen
Asian Journal of Surgery.2023; 46(10): 4196. CrossRef
Safety and efficacy of laparoscopic proximal gastrectomy with SOFY versus laparoscopic total gastrectomy with Roux-en-Y for treating cT1-2 Siewert II/III adenocarcinoma of the esophagogastric junction: a single-center prospective cohort study
Haiqiao Zhang, Zhi Zheng, Xiaoye Liu, Chenglin Xin, Yong Huang, Yuan Li, Jie Yin, Jun Zhang
Langenbeck's Archives of Surgery.2023;[Epub] CrossRef
Research Progress and Thinking on the Surgical Treatment of Siewert Type II Adenocarcinoma of the Esophagogastric Junction
宏宇谢
Advances in Clinical Medicine.2023; 13(02): 1914. CrossRef
The comparison of long-term oncological outcomes and complications after proximal gastrectomy with double tract reconstruction versus total gastrectomy for proximal gastric cancer
Keming Ying, Weisong Bai, Guiru Yan, Ziseng Xu, Shenheng Du, Chengxue Dang
World Journal of Surgical Oncology.2023;[Epub] CrossRef
The clinical outcomes of laparoscopic proximal gastrectomy with double-tract reconstruction versus tube-like stomach reconstruction in patients with adenocarcinoma of the esophagogastric junction based on propensity score-matching: a multicenter cohort st
Zhiwen Xu, Jinping Chen, Shaoqin Chen, Hexin Lin, Kang Zhao, Changyue Zheng, Huibin Liu, Zhihua Chen, Yongan Fu, Qingqi Hong, Wei Lin, Su Yan, Jun You
Frontiers in Oncology.2023;[Epub] CrossRef
A novel trans hiatal esophago-gastrostomy with anti-reflux triangle-valve for laparoscope assisted lower esophagectomy and proximal gastrectomy for Siewert type II/III adenocarcinoma of the esophagogastric junction: a three-year retrospective cohort study
Yongshun Gao, Jiangang Sun, Peng Chen
European Surgery.2023; 55(5-6): 124. CrossRef
Surgical outcomes of laparoscopic proximal gastrectomy for upper-third gastric cancer: esophagogastrostomy, gastric tube reconstruction, and double-tract reconstruction
Jianhua Chen, Fei Wang, Shuyang Gao, Yapeng Yang, Ziming Zhao, Jiahao Shi, Liuhua Wang, Jun Ren
BMC Surgery.2023;[Epub] CrossRef
Minimally invasive surgery for gastro-oesophageal junction adenocarcinoma: Current evidence and future perspectives
Rodica Bîrlă, Petre Hoara, Florin Achim, Valeriu Dinca, Diana Ciuc, Silviu Constantinoiu, Adrian Constantin
World Journal of Gastrointestinal Oncology.2023; 15(10): 1675. CrossRef
Comparison of proximal gastrectomy with double-flap technique and double-tract reconstruction for proximal early gastric cancer: a meta-analysis
Qiao-zhen Huang, Peng-cheng Wang, Yan-xin Chen, Shu Lin, Kai Ye
Updates in Surgery.2023; 75(8): 2117. CrossRef
Comparison of the prognosis of four different surgical strategies for proximal gastric cancer: a network meta-analysis
Ling Tan, Meng-ni Ran, Zi-lin Liu, Ling-han Tang, Zhou Ma, Zhou He, Zhou Xu, Fang-han Li, Jiang-wei Xiao
Langenbeck's Archives of Surgery.2022; 407(1): 63. CrossRef
Protocol for Comparing the Efficacy of Three Reconstruction Methods of the Digestive Tract (Kamikawa Versus Double-Tract Reconstruction Versus Tube-Like Stomach) After Proximal Gastrectomy
Wei Dong Wang, Rui Qi Gao, Tong Chen, Dan Hong Dong, Qin Chuan Yang, Hai Kun Zhou, Jiang Peng Wei, Peng Fei Yu, Xi Sheng Yang, Xiao Hua Li, Gang Ji
Frontiers in Surgery.2022;[Epub] CrossRef
A review on double tract reconstruction after proximal gastrectomy for proximal gastric cancer
Tricia S. Lewis, YongDong Feng
Annals of Medicine and Surgery.2022; 79: 103879. CrossRef
Clinical Comparison of Proximal Gastrectomy With Double-Tract Reconstruction Versus Total Gastrectomy With Roux-en-Y Anastomosis for Siewert Type II/III Adenocarcinoma of the Esophagogastric Junction
Xiaoming Ma, Mingzuo Zhao, Jian Wang, Haixing Pan, Jianqiang Wu, Chungen Xing
Journal of Gastric Cancer.2022; 22(3): 220. CrossRef
Surgical considerations and outcomes of minimally invasive approaches for gastric cancer resection
Cecilia T. Ong, Jason L. Schwarz, Kevin K. Roggin
Cancer.2022; 128(22): 3910. CrossRef

6,922 View
191 Download
26 Web of Science
23 Crossref

Gastrointestinal cancer

An Innovative Prognostic Model Based on Four Genes in Asian Patient with Gastric Cancer: Jiahui Chen, Anqiang Wang, Jun Ji, Kai Zhou, Zhaode Bu, Guoqing Lyu, Jiafu Ji; Cancer Res Treat. 2021;53(1):148-161. Published online August 31, 2020; DOI: https://doi.org/10.4143/crt.2020.424

Abstract PDF Supplementary Material PubReader ePub

Purpose
Gastric cancer (GC) has substantial biological differences between Asian and non-Asian populations, which makes it difficult to have a unified predictive measure for all people. We aimed to identify novel prognostic biomarkers to help predict the prognosis of Asian GC patients.
Materials and Methods
We investigated the differential gene expression between GC and normal tissues of GSE66229. Univariate, multivariate and Lasso Cox regression analyses were conducted to establish a four-gene-related prognostic model based on the risk score. The risk score was based on a linear combination of the expression levels of individual genes multiplied by their multivariate Cox regression coefficients. Validation of the prognostic model was conducted using The Cancer Genome Atlas (TCGA) database. A nomogram containing clinical characteristics and the prognostic model was established to predict the prognosis of Asian GC patients.
Results
Four genes (RBPMS2, RGN, PLEKHS1, and CT83) were selected to establish the prognostic model, and it was validated in the TCGA Asian cohort. Receiver operating characteristic analysis confirmed the sensitivity and specificity of the prognostic model. Based on the prognostic model, a nomogram containing clinical characteristics and the prognostic model was established, and Harrell’s concordance index of the nomogram for evaluating the overall survival significantly higher than the model only focuses on the pathologic stage (0.74 vs. 0.64, p < 0.001).
Conclusion
The four-gene-related prognostic model and the nomogram based on it are reliable tools for predicting the overall survival of Asian GC patients.

Citations

Citations to this article as recorded by

Nivolumab plus anlotinib hydrochloride in advanced gastric adenocarcinoma and esophageal squamous cell carcinoma: the phase II OASIS trial
Jing Wu, Shilong Zhang, Shan Yu, Guo An, Yi Wang, Yiyi Yu, Li Liang, Yan Wang, Xiaojing Xu, YanShi Xiong, Di Shao, Zhun Shi, Nannan Li, Jingyuan Wang, Dawei Jin, Tianshu Liu, Yuehong Cui
Nature Communications.2024;[Epub] CrossRef
An integrated analysis of prognostic mRNA signature in early- and progressive-stage gastric adenocarcinoma
Xiaoling Hong, Kai Zhuang, Na Xu, Jiang Wang, Yong Liu, Siqi Tang, Junzhang Zhao, Zunnan Huang
Frontiers in Molecular Biosciences.2023;[Epub] CrossRef
Analysis and application of RNA binding protein gene pairs to predict the prognosis of gastric cancer
Zhi-kun Ning, Hua-kai Tian, Jiang Liu, Ce-gui Hu, Zi-tao Liu, Hui Li, Zhen Zong
Heliyon.2023; 9(7): e18242. CrossRef
PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
Tamara A.M. Chessa, Piotr Jung, Arqum Anwar, Sabine Suire, Karen E. Anderson, David Barneda, Anna Kielkowska, Barzan A. Sadiq, Ieng Wai Lai, Sergio Felisbino, Daniel J. Turnham, Helen B. Pearson, Wayne A. Phillips, Junko Sasaki, Takehiko Sasaki, David Oxl
Molecular Cell.2023; 83(16): 2991. CrossRef
Evaluation of vital genes correlated with CD8 + T cell infiltration as prognostic biomarkers in stomach adenocarcinoma
Dun Pan, Hui Chen, Jiaxiang Xu, Xin Lin, Liangqing Li
BMC Gastroenterology.2023;[Epub] CrossRef
Bayesian hierarchical lasso Cox model: A 9-gene prognostic signature for overall survival in gastric cancer in an Asian population
Jiadong Chu, Na Sun, Wei Hu, Xuanli Chen, Nengjun Yi, Yueping Shen, Andy T. Y. Lau
PLOS ONE.2022; 17(4): e0266805. CrossRef
Three Prognostic Biomarkers Correlate with Immune Checkpoint Blockade Response in Bladder Urothelial Carcinoma
Ya Guo, Yin Bin Zhang, Yi Li, Wang Hui Su, Shan He, Shu Pei Pan, Kun Xu, Wei Hua Kou, Luca Falzone
International Journal of Genomics.2022; 2022: 1. CrossRef
KK-LC-1 may be an effective prognostic biomarker for gastric cancer
Jun Ji, Jiahui Chen, Anqiang Wang, Wei Zhang, Hongge Ju, Yang Liu, Leping Li
BMC Cancer.2021;[Epub] CrossRef
Multiomics analysis reveals CT83 is the most specific gene for triple negative breast cancer and its hypomethylation is oncogenic in breast cancer
Chen Chen, Dan Gao, Jinlong Huo, Rui Qu, Youming Guo, Xiaochi Hu, Libo Luo
Scientific Reports.2021;[Epub] CrossRef
Integrative analysis-based identification and validation of a prognostic immune cell infiltration-based model for patients with advanced gastric cancer
Siwei Pan, Qi Gao, Qingchuan Chen, Pengfei Liu, Yuen Tan, Funan Liu, Huimian Xu
International Immunopharmacology.2021; 101: 108258. CrossRef

9,141 View
184 Download
12 Web of Science
10 Crossref

First
Prev
Page of 1
Next
Last

Search