Cancer Research and Treatment

Original Articles

The Use of CD44 Variant 9 and Ki-67 Combination Can Predicts Prognosis Better Than Their Single Use in Early Gastric Cancer: Se-Il Go, Gyung Hyuck Ko, Won Sup Lee, Jeong-Hee Lee, Sang-Ho Jeong, Young-Joon Lee, Soon Chan Hong, Woo Song Ha; Cancer Res Treat. 2019;51(4):1411-1419. Published online February 25, 2019; DOI: https://doi.org/10.4143/crt.2018.663

Abstract PDF Supplementary Material PubReader ePub

Purpose
We previously demonstrated that CD44v9 and Ki-67 played an important role in predicting poor prognosis of early gastric cancer (EGC). However, little is known about combined use of both biomarkers as prognostic biomarker. The present study was performed to investigate the significance of CD44v9 and Ki-67 expression as a combination biomarker for EGC.
Materials and Methods
With tissue microarray for 158 EGC tissues, we performed immunohistochemical staining for CD44v9 and Ki-67. The whole patients were divided into three groups (group A, CD44v9- negative/Ki-67–low; group B, neither group A or C; and group C, CD44v9-positive/Ki-67– high). Its clinical significance was re-analyzed with adjustment via propensity score matching (PSM). For validation, we performed bootstrap resampling.
Results
The median follow-up duration was 90.4 months (range, 3.7 to 120.4 months). In the comparison according to CD44v9/Ki-67 expression, the combined use of the two biomarker clearly separated the three groups by 5-year survival rates (5-YSR, 96.3%, 89.8%, and 76.8% in group A, B, and C, respectively; p=0.009). After PSM, 5-YSR were 97.7% and 76.8% in group A+B and group C, respectively (p=0.002). Multivariable analysis demonstrated that group C had independently poor prognosis (hazard ratio, 9.137; 95% confidence interval, 1.187 to 70.366; p=0.034) compared with group A. Bootstrap resampling internally validated this result (p=0.016).
Conclusion
This study suggests that both positive CD44v9 and high Ki-67 expression are associated with poor prognosis in EGC, and the combined use of these markers provides better prognostic stratification than the single use of them.

Citations

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The Prognostic Importance of Ki-67 in Gastrointestinal Carcinomas: A Meta-analysis and Multi-omics Approach
Mahdieh Razmi, Fatemeh Tajik, Farideh Hashemi, Ayna Yazdanpanah, Fatemeh Hashemi-Niasari, Adeleh Divsalar
Journal of Gastrointestinal Cancer.2024; 55(2): 599. CrossRef
Impact of Alcian blue and periodic acid Schiff expression on the prognosis of gastric signet ring cell carcinoma
Juan Lin, Zhu-Feng Chen, Guo-Dong Guo, Xin Chen
World Journal of Gastrointestinal Oncology.2024; 16(3): 687. CrossRef
Significance of concurrent evaluation of HER2 gene amplification and p53 and Ki67 expression in gastric cancer tissues
Su-nan Wang, Yang-kun Wang, Chao-ya Zhu, Bo Jiang, Dong-feng Ge, Ying-ying Li
Clinical and Translational Oncology.2024; 27(1): 126. CrossRef
Downregulation of MTHFD2 Inhibits Proliferation and Enhances Chemosensitivity in Hepatocellular Carcinoma via PI3K/AKT Pathway
Jie Wang, Ze Yu, Yixiao Jiang, Ting Le, Yixin Wu, Ziqi Li, Guoqiang Zhang, Feiyue Wu, Haijie Ma
Frontiers in Bioscience-Landmark.2024;[Epub] CrossRef
Analysis of risk factors for lymph node metastasis and prognosis study in patients with early gastric cancer: A SEER data-based study
Jinzhou Li, Ting Cui, Zeping Huang, Yanxi Mu, Yalong Yao, Wei Xu, Kang Chen, Haipeng Liu, Wenjie Wang, Xiao Chen
Frontiers in Oncology.2023;[Epub] CrossRef
Revisiting therapeutic strategies for ovarian cancer by focusing on redox homeostasis (Review)
Hiroshi Kobayashi, Shogo Imanaka, Hiroshi Shigetomi
Oncology Letters.2022;[Epub] CrossRef
Cyclin D1 Serves as a Poor Prognostic Biomarker in Stage I Gastric Cancer
Se-Il Go, Gyung Hyuck Ko, Won Sup Lee, Jeong-Hee Lee, Sang-Ho Jeong, Young-Joon Lee, Soon Chan Hong, Woo Song Ha
Current Issues in Molecular Biology.2022; 44(3): 1395. CrossRef
Analysis of Endoscopy Findings to Identify Early Gastric Cancers with Tumor Budding: A Retrospective Study
Lanqing Cao, Zhaoyong Wang, Liwei Duan, Lijuan Wei
Journal of Gastrointestinal Surgery.2021; 25(7): 1706. CrossRef
Clinical significance of circulating tumour cells and Ki-67 in renal cell carcinoma
Jinbo Song, Zhe Yu, Bingqi Dong, Mingkai Zhu, Xiaofeng Guo, Yongkang Ma, Shiming Zhao, Tiejun Yang
World Journal of Surgical Oncology.2021;[Epub] CrossRef
Fascin‑1 is associated with recurrence in solitary fibrous tumor/hemangiopericytoma
Yumiko Yamamoto, Yoshihiro Hayashi, Hideyuki Sakaki, Ichiro Murakami
Molecular and Clinical Oncology.2021;[Epub] CrossRef
Identification of novel biomarkers, MUC5AC, MUC1, KRT7, GAPDH, CD44 for gastric cancer
Jie Yang
Medical Oncology.2020;[Epub] CrossRef
Roles of Proteoglycans and Glycosaminoglycans in Cancer Development and Progression
Jinfen Wei, Meiling Hu, Kaitang Huang, Shudai Lin, Hongli Du
International Journal of Molecular Sciences.2020; 21(17): 5983. CrossRef

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14 Web of Science
12 Crossref

Population-Based Regional Cancer Incidence in Korea: Comparison between Urban and Rural Areas: Haa-Na Song, Se-Il Go, Won Sup Lee, Yire Kim, Hye Jung Choi, Un Seok Lee, Myoung Hee Kang, Gyeong-Won Lee, Hoon-Gu Kim, Jung Hun Kang, Yune Sik Kang, Jeong-Hee Lee, Jin-Myung Jung, Soon Chan Hong; Cancer Res Treat. 2016;48(2):789-797. Published online July 14, 2015; DOI: https://doi.org/10.4143/crt.2015.062

Abstract PDF PubReader ePub

Purpose
The purpose of this study is to investigate differences in organ-specific cancer incidence according to the region and population size in Korea.
Materials and Methods
We reviewed the data of the cancer registration program of Gyeongnam Regional Cancer Center between 2008 and 2011. Age-standardized rates of cancer incidence were analyzed according to population size of the region and administrative zone.
Results
Incidence of thyroid cancer has been increasing rapidly in both urban and rural areas. However, the thyroid cancer incidence was much lower in rural areas than in urban areas and megalopolis such as Seoul. Gastric cancer was relatively more common in rural areas, in megalopolis near the sea (Ulsan, Busan, and Incheon), and other southern provinces (Chungcheongnam-do, Gyeongsangbuk-do, and Gyeongsangnam-do). A detailed analysis in Gyeongsangnam-do revealed that rural areas have relatively low incidence of thyroid and colorectal cancer, and relatively high incidence of gastric and lung cancer compared to urban areas.
Conclusion
This study suggests that there are some differences in cancer incidence by population size. Thyroid and colorectal cancer incidence was increasing, and gastric and lung cancer was slightly decreasing in urban areas, whereas gastric and lung cancer incidence still remains high in rural areas.

Citations

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Choy‐Lye Chei, Sho Nakamura, Kaname Watanabe, Ryo Watanabe, Akio Kurokawa, Taizo Iwane, Sayaka Itoh, Hiroto Narimatsu
Cancer Science.2025; 116(2): 488. CrossRef
Preliminary reports of lung cancer screening with low-dose computed tomography: a nationwide performance on the Korean population in 2019–2020
Horim A. Hwang, Dong Jun Kim, Nan-He Yoon, Jae Kwan Jun, Mina Suh, Sunhwa Lee, Seongju Kim, Seung Eun Jung, Hooyeon Lee
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Urban Scaling of Health Outcomes: a Scoping Review
Edwin M. McCulley, Pricila H. Mullachery, Ana F. Ortigoza, Daniel A. Rodríguez, Ana V. Diez Roux, Usama Bilal
Journal of Urban Health.2022; 99(3): 409. CrossRef
Loss of Novel Diversity in Human Gut Microbiota Associated with Ongoing Urbanization in China
Shan Sun, Huijun Wang, Annie Green Howard, Jiguo Zhang, Chang Su, Zhihong Wang, Shufa Du, Anthony A. Fodor, Penny Gordon-Larsen, Bing Zhang, Emily B. Graham
mSystems.2022;[Epub] CrossRef
Deciphering the impact of urban built environment density on respiratory health using a quasi-cohort analysis of 5495 non-smoking lung cancer cases
Lan Wang, Wenyao Sun, Anne Vernez Moudon, Yong-Guan Zhu, Jinfeng Wang, Pingping Bao, Xiaojing Zhao, Xiaoming Yang, Yinghui Jia, Surong Zhang, Shuang Wu, Yuxi Cai
Science of The Total Environment.2022; 850: 158014. CrossRef
Difference in medical service use among Korean gastric cancer survivors according to regional healthcare vulnerabilities: a cohort study
Sung Hoon Jeong, Jae Hong Joo, Minah Park, Choa Yun, Soo Hyun Kang, Eun-Cheol Park, Yoon Dae Han, Sung-In Jang
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Apoptotic Effects of Anthocyanins from Vitis coignetiae Pulliat Are Enhanced by Augmented Enhancer of the Rudimentary Homolog (ERH) in Human Gastric Carcinoma MKN28 Cells
Cheol Park, Won Sup Lee, Se-Il Go, Sang-Ho Jeong, Jiyun Yoo, Hee-Jae Cha, Young-Joon Lee, Heui-Soo Kim, Sun-Hee Leem, Hye Jung Kim, Gon Sup Kim, Soon-Chan Hong, Yung Hyun Choi
International Journal of Molecular Sciences.2021; 22(6): 3030. CrossRef
Current therapeutic options for gastric adenocarcinoma
C.R. Akshatha, Smitha Bhat, R. Sindhu, Dharini Shashank, Sarana Rose Sommano, Wanaporn Tapingkae, Ratchadawan Cheewangkoon, Shashanka K. Prasad
Saudi Journal of Biological Sciences.2021; 28(9): 5371. CrossRef
Impact of Rurality on National Trends in Thyroid Cancer Incidence and Long‐Term Survival
Alexandria D. McDow, Whitney E. Zahnd, Peter Angelos, John D. Mellinger, Sabha Ganai
The Journal of Rural Health.2020; 36(3): 326. CrossRef
Predicted Future Mortality Attributed to Increases in Temperature and PM10 Concentration under Representative Concentration Pathway Scenarios
Jiyun Jung, Jae Young Lee, Hyewon Lee, Ho Kim
International Journal of Environmental Research and Public Health.2020; 17(7): 2600. CrossRef
Polyphenols Extracted from Artemisia annua L. Exhibit Anti-Cancer Effects on Radio-Resistant MDA-MB-231 Human Breast Cancer Cells by Suppressing Stem Cell Phenotype, β-Catenin, and MMP-9
Young Shin Ko, Eun Joo Jung, Se-il Go, Bae Kwon Jeong, Gon Sup Kim, Jin-Myung Jung, Soon Chan Hong, Choong Won Kim, Hye Jung Kim, Won Sup Lee
Molecules.2020; 25(8): 1916. CrossRef
Temporal and geographical variations in colorectal cancer incidence in Northern Iran 2004–2013
Susan Hasanpour-Heidari, Abdolreza Fazel, Shahryar Semnani, Seyyed-Reza Khandoozi, Taghi Amiriani, SeyedMehdi Sedaghat, Reza Hosseinpoor, Ramin Azarhoush, Mohammad Poorabbasi, Mohammad Naeimi-Tabiei, Gholamreza Roshandel, Freddie Bray, Elisabete Weiderpas
Cancer Epidemiology.2019; 59: 143. CrossRef
Regional Differences in Years of Life Lost in Korea from 1997 to 2015
Dun-Sol Go, Young-Eun Kim, Munkhzul Radnaabaatar, Yunsun Jung, Jaehun Jung, Seok-Jun Yoon
Journal of Korean Medical Science.2019;[Epub] CrossRef
Morin enhances auranofin anticancer activity by up‐regulation of DR4 and DR5 and modulation of Bcl‐2 through reactive oxygen species generation in Hep3B human hepatocellular carcinoma cells
Hyun Hwang‐Bo, Won Sup Lee, Arulkumar Nagappan, Hong Jae Kim, Radha Panchanathan, Cheol Park, Seong‐Hwan Chang, Nam Deuk Kim, Sun‐Hee Leem, Young‐Chae Chang, Taeg Kyu Kwon, Jae Hun Cheong, Gon Sup Kim, Jin‐Myung Jung, Sung Chul Shin, Soon Chan Hong, Yung
Phytotherapy Research.2019; 33(5): 1384. CrossRef
The Use of CD44 Variant 9 and Ki-67 Combination Can Predicts Prognosis Better Than Their Single Use in Early Gastric Cancer
Se-Il Go, Gyung Hyuck Ko, Won Sup Lee, Jeong-Hee Lee, Sang-Ho Jeong, Young-Joon Lee, Soon Chan Hong, Woo Song Ha
Cancer Research and Treatment.2019; 51(4): 1411. CrossRef
Cancer Incidence Trend in the Hebei Spirit Oil Spill Area, from 1999 to 2014: An Ecological Study
Kyung-Hwa Choi, Myung-Sook Park, Mina Ha, Jong-Il Hur, Hae-Kwan Cheong
International Journal of Environmental Research and Public Health.2018; 15(5): 1006. CrossRef
Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization
Huan Li, Tongtong Li, Xiangzhen Li, Guanhong Wang, Qiang Lin, Jiapeng Qu
Frontiers in Microbiology.2018;[Epub] CrossRef
Regional Differences in Years of Life Lost in Korea from 1997 to 2015
Dun-Sol Go, Young-Eun Kim, Munkhzul Radnaabaatar, Yunsun Jung, Jaehun Jung, Seok-Jun Yoon
Journal of Korean Medical Science.2018;[Epub] CrossRef
Estimation of the Incidence of Hepatocellular Carcinoma and Cholangiocarcinoma in Songkhla, Thailand, 1989-2013, Using Multiple Imputation Method
Seesai Yeesoonsang, Surichai Bilheem, Edward McNeil, Sophon Iamsirithaworn, Chuleeporn Jiraphongsa, Hutcha Sriplung
Cancer Research and Treatment.2017; 49(1): 54. CrossRef
Prognostic impact of Ki-67 in patients with gastric cancer—the importance of depth of invasion and histologic differentiation
Gyung Hyuck Ko, Se-Il Go, Won Sup Lee, Jeong-Hee Lee, Sang-Ho Jeong, Young-Joon Lee, Soon Chan Hong, Woo Song Ha
Medicine.2017; 96(25): e7181. CrossRef
Recent urbanization in China is correlated with a Westernized microbiome encoding increased virulence and antibiotic resistance genes
Kathryn Winglee, Annie Green Howard, Wei Sha, Raad Z. Gharaibeh, Jiawu Liu, Donghui Jin, Anthony A. Fodor, Penny Gordon-Larsen
Microbiome.2017;[Epub] CrossRef

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111 Download
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CD44 Variant 9 Serves as a Poor Prognostic Marker in Early Gastric Cancer, But Not in Advanced Gastric Cancer: Se-Il Go, Gyung Hyuck Ko, Won Sup Lee, Rock Bum Kim, Jeong-Hee Lee, Sang-Ho Jeong, Young-Joon Lee, Soon Chan Hong, Woo Song Ha; Cancer Res Treat. 2016;48(1):142-152. Published online March 17, 2015; DOI: https://doi.org/10.4143/crt.2014.227

Abstract PDF PubReader ePub

Purpose
The present study is to investigate the significance of CD44 variant 9 (CD44v9) expression as a biomarker in primary gastric cancer.
Materials and Methods
With various gastric tissues, we performed immunohistochemical staining for CD44v9.
Results
The positive expression rates for CD44v9 in tumor, including adenoma, early gastric cancer (EGC), and advanced gastric cancer (AGC), were higher than those in non-tumor tissues (p = 0.003). In addition, the higher expression for CD44v9 was observed as the tissue becomes malignant. In the analysis of 333 gastric cancer tissues, we found that positive expression rates for CD44v9 were higher in the intestinal type or well differentiated gastric cancer than in the diffuse type or poorly differentiated gastric cancer. Interestingly, the positive expression indicated poor prognosis in EGC (5-YSR in stage I, 81.7% vs 95.2%; p = 0.013), but not in AGC (5-YSR in stage II, 66.9% vs 62.2%; p = 0.821, 5-YSR in stage III, 34.5% vs 32.0%; p = 0.929). Moreover, strong positive expression (3+) showed a trend suggesting worse prognosis only in EGC, and it appeared to be associated with lymph node metastasis.
Conclusion
This study suggests that CD44v9 may be a good biomarker for prognosis prediction and for chemoprevention or biomarker-driven therapies only for EGC.

Citations

Citations to this article as recorded by

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Cyclin D1 Serves as a Poor Prognostic Biomarker in Stage I Gastric Cancer
Se-Il Go, Gyung Hyuck Ko, Won Sup Lee, Jeong-Hee Lee, Sang-Ho Jeong, Young-Joon Lee, Soon Chan Hong, Woo Song Ha
Current Issues in Molecular Biology.2022; 44(3): 1395. CrossRef
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C.R. Akshatha, Smitha Bhat, R. Sindhu, Dharini Shashank, Sarana Rose Sommano, Wanaporn Tapingkae, Ratchadawan Cheewangkoon, Shashanka K. Prasad
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The Use of CD44 Variant 9 and Ki-67 Combination Can Predicts Prognosis Better Than Their Single Use in Early Gastric Cancer
Se-Il Go, Gyung Hyuck Ko, Won Sup Lee, Jeong-Hee Lee, Sang-Ho Jeong, Young-Joon Lee, Soon Chan Hong, Woo Song Ha
Cancer Research and Treatment.2019; 51(4): 1411. CrossRef
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125 Download
38 Web of Science
34 Crossref

Case Report

Cyclosporine A as a Primary Treatment for Panniculitis-like T Cell Lymphoma: A Case with a Long-Term Remission: Won Sup Lee, Ji-Hyen Hwang, Moon Jin Kim, Se-Il Go, Anna Lee, Haa-Na Song, Min Jeong Lee, Myung Hee Kang, Hoon-Gu Kim, Jeong-Hee Lee; Cancer Res Treat. 2014;46(3):312-316. Published online July 15, 2014; DOI: https://doi.org/10.4143/crt.2014.46.3.312

Abstract PDF PubReader ePub

Subcutaneous panniculitis-like T cell lymphoma (SPTL) is a distinctive cutaneous lymphoma characterized by an infiltration of subcutaneous tissue by neoplastic T cells, similar to panniculitis. It is well-established that patients who are diagnosed with SPTL usually respond poorly to chemotherapy, showing fatal outcome. As a first line treatment for SPTL, anthracycline-based chemotherapy was most frequently used. For the treatment of SPTL, the efficacy of cyclosporine A has been recently reported in relapsed SPTL after anthracycline-based chemotherapy. However, it is still not clear whether cyclosporine A can be used as a first-line treatment against SPTL. Here, we report a case of SPTL, which achieved complete remission for nine years after first-line cyclosporine A therapy. This study suggests that cyclosporine A can induce a complete long-term remission as a first-line treatment.

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En‐Cheng Lin, Jia‐Bin Liao, Yu‐Han Fang, Chien‐Hui Hong
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