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- Lung and Thoracic cancer
- The Profile of Gut Microbiota in Carcinogenesis Driven by Mutant EGFR in Non–Small Cell Lung Cancer
- Da-Som Kim, Eun Hye Kim, Ji Yong Kim, Dong Ha Kim, Yun Jung Choi, Jaeyi Jeong, Young Hoon Sung, Dong-Cheol Woo, Chong Jai Kim, Jae Cheol Lee, Miyong Yun, Jin-Yong Jeong, Jin Kyung Rho
- Cancer Res Treat. 2026;58(1):115-127. Published online March 4, 2025
- DOI: https://doi.org/10.4143/crt.2024.1177
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Abstract
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PubReader
ePub - Purpose
Accumulating evidence has clarified that gut dysbiosis is involved in lung cancer development and progression. Although the relationship between tumors and gut microbiota has been extensively studied using clinical samples, no studies have examined the association between mutant epidermal growth factor receptor (EGFR)–induced lung carcinogenesis and dysbiosis in gut microbiota. Therefore, we investigated the gut microbiota profiles in stool samples from human lung-specific conditional EGFR-mutant transgenic mice during lung tumor carcinogenesis.
Materials and Methods
Stool samples were collected before tamoxifen treatment (V1) and at each time point following mutant EGFR expression in lung tissue (V2) and lung tumor appearance (V3). Fecal 16S rRNA taxonomy was analyzed to assess microbial diversity, composition, and dynamic changes at each time point.
Results
We found that microbiota richness and diversity were significantly elevated when tumors developed and grew in the lung. Phylogenetic analysis of the microbial community revealed that Lachnospiraceae, Ruminococcaceae, Porphyromonadaceae, Rhodospirillaceae, Odoribacteraceae, and Desulfovibrionaceae showed a significant increase at the V3 stage compared to the V1 stage at the family level. In contrast, Lactobacillaceae, Bacteroidaceae, Muribaculaceae, Coriobacteriaceae, and Rikenellaceae significantly decreased at the V3 stage compared to the V1 stage. Furthermore, Lactobacillus species, also known as short chain fatty acid-producing bacteria, were relatively abundant at the V1 stage but were depleted with the occurrence of lung tumors at the V3 stage.
Conclusion
Changes in gut microbiota, such as Lactobacillus species, may be a predictive factor for the emergence and progression of tumors in an animal model of lung adenocarcinoma induced by mutant EGFR. -
Citations
Citations to this article as recorded by
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Microbiome and
EGFR
-mutant non-small cell lung cancer: a complex interplay
Serena Eccher, Marco Sposito, Ilaria Mariangela Scaglione, Luca Pasqualin, Michele Rota, Adele Bonato, Lucia Longo, Alice Avancini, Ilaria Trestini, Daniela Tregnago, Jessica Insolda, Michele Milella, Sara Pilotto, Lorenzo Belluomini
Expert Review of Clinical Immunology.2026; 22(3): 295. CrossRef - Hericium erinaceus Extracts Exert Gastroprotective Effects Through Modulation of the Gut Microbiota and Metabolites
Ruixin Bei, Lifan Yu, Zhonghua Lu, Tingxuan Zong, Yanfang Sun
Food Science & Nutrition.2026;[Epub] CrossRef - Gut microbiota and metabolites: emerging prospects in the treatment of non-small cell lung cancer
Jing-Mian Jiao, Chen-Guang Liu, Dan Zang, Jun Chen
Frontiers in Immunology.2025;[Epub] CrossRef - Study on the Impact of Changes in Intestinal Microbiota Structure of Lung Cancer Patients on the Efficacy of Immune Checkpoint Inhibitors
静 鲁
Advances in Clinical Medicine.2025; 15(11): 744. CrossRef
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Microbiome and
EGFR
-mutant non-small cell lung cancer: a complex interplay
- 5,438 View
- 166 Download
- 4 Web of Science
- 4 Crossref
- Contribution of Enhanced Locoregional Control to Improved Overall Survival with Consolidative Durvalumab after Concurrent Chemoradiotherapy in Locally Advanced Non–Small Cell Lung Cancer: Insights from Real-World Data
- Jeong Yun Jang, Si Yeol Song, Young Seob Shin, Ha Un Kim, Eun Kyung Choi, Sang-We Kim, Jae Cheol Lee, Dae Ho Lee, Chang-Min Choi, Shinkyo Yoon, Su Ssan Kim
- Cancer Res Treat. 2024;56(3):785-794. Published online January 16, 2024
- DOI: https://doi.org/10.4143/crt.2023.1014
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Abstract
PDF
Supplementary MaterialPubReaderePub - Purpose
This study aimed to assess the real-world clinical outcomes of consolidative durvalumab in patients with unresectable locally advanced non–small cell lung cancer (LA-NSCLC) and to explore the role of radiotherapy in the era of immunotherapy.
Materials and Methods
This retrospective study assessed 171 patients with unresectable LA-NSCLC who underwent concurrent chemoradiotherapy (CCRT) with or without consolidative durvalumab at Asan Medical Center between May 2018 and May 2021. Primary outcomes included freedom from locoregional failure (FFLRF), distant metastasis-free survival (DMFS), progression-free survival (PFS), and overall survival (OS).
Results
Durvalumab following CCRT demonstrated a prolonged median PFS of 20.9 months (p=0.048) and a 3-year FFLRF rate of 57.3% (p=0.008), compared to 13.7 months and 38.8%, respectively, with CCRT alone. Furthermore, the incidence of in-field recurrence was significantly greater in the CCRT-alone group compared to the durvalumab group (26.8% vs. 12.4%, p=0.027). While median OS was not reached with durvalumab, it was 35.4 months in patients receiving CCRT alone (p=0.010). Patients positive for programmed cell death ligand 1 (PD-L1) expression showed notably better outcomes, including FFLRF, DMFS, PFS, and OS. Adherence to PACIFIC trial eligibility criteria identified 100 patients (58.5%) as ineligible. The use of durvalumab demonstrated better survival regardless of eligibility criteria.
Conclusion
The use of durvalumab consolidation following CCRT significantly enhanced locoregional control and OS in patients with unresectable LA-NSCLC, especially in those with PD-L1–positive tumors, thereby validating the role of durvalumab in standard care. -
Citations
Citations to this article as recorded by- A Real-World, Single-Center, Observational Retrospective Experience of Durvalumab Treatment After Concomitant Chemoradiation for Unresectable Stage III Non-Small Cell Lung Cancer
Agnieszka Wojskowicz, Piotr Skalij, Dominika Hempel, Łukasz Zalewski, Monika Konopka-Filippow, Iwona Sidorkiewicz, Agnieszka Krzystyniak, Ewa Sierko
Cancers.2026; 18(6): 1044. CrossRef - Targeting the METTL14/Wnt9a/β-catenin pathway with pharmacological inhibitors enhances radiotherapy and immunotherapy efficacy in non-small cell lung cancer
Kaifeng Ji, Rong Yu, Wei Zhang, Hao Yang, Longtai You, Zhijun Li
European Journal of Pharmacology.2026; 1032: 179195. CrossRef - Efficacy and adverse events of immune checkpoint inhibitors: evidence from non-small cell lung cancer and gastric cancer in Korea and Japan
Mc Neil Valencia, Zeeshan Abbas, Seung Won Lee
Precision and Future Medicine.2025; 9(1): 15. CrossRef - Effect of interleukin-6 and interleukin-8 levels on pathogenic bacteria types in patients with advanced lung cancer and pulmonary infection during chemotherapy
Xiaodan Zheng
American Journal of Translational Research.2025; 17(6): 4723. CrossRef - Therapeutic effect of induction therapy including nab-paclitaxel followed by surgical resection for the patients with locally advanced non-small-cell lung cancer
Hidetaka Uramoto, Nozomu Motono, Shun Iwai
Journal of Cardiothoracic Surgery.2024;[Epub] CrossRef
- A Real-World, Single-Center, Observational Retrospective Experience of Durvalumab Treatment After Concomitant Chemoradiation for Unresectable Stage III Non-Small Cell Lung Cancer
- 8,228 View
- 195 Download
- 7 Web of Science
- 5 Crossref
- General
- Impact of Patient Sex on Adverse Events and Unscheduled Utilization of Medical Services in Cancer Patients Undergoing Adjuvant Chemotherapy: A Multicenter Retrospective Cohort Study
- Songji Choi, Seyoung Seo, Ju Hyun Lee, Koung Jin Suh, Ji-Won Kim, Jin Won Kim, Se Hyun Kim, Yu Jung Kim, Keun-Wook Lee, Jwa Hoon Kim, Tae Won Kim, Yong Sang Hong, Sun Young Kim, Jeong Eun Kim, Sang-We Kim, Dae Ho Lee, Jae Cheol Lee, Chang-Min Choi, Shinkyo Yoon, Su-Jin Koh, Young Joo Min, Yongchel Ahn, Hwa Jung Kim, Jin Ho Baek, Sook Ryun Park, Jee Hyun Kim
- Cancer Res Treat. 2024;56(2):404-413. Published online November 7, 2023
- DOI: https://doi.org/10.4143/crt.2023.784
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Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
The female sex is reported to have a higher risk of adverse events (AEs) from cytotoxic chemotherapy. Few studies examined the sex differences in AEs and their impact on the use of medical services during adjuvant chemotherapy. This sub-study aimed to compare the incidence of any grade and grade ≥ 3 AEs, healthcare utilization, chemotherapy completion rate, and dose intensity according to sex.
Materials and Methods
This is a sub-study of a multicenter cohort conducted in Korea that evaluated the impact of healthcare reimbursement on AE evaluation in patients who received adjuvant chemotherapy between September 2013 and December 2016 at four hospitals in Korea.
Results
A total of 1,170 patients with colorectal, gastric, or non–small cell lung cancer were included in the study. Female patients were younger, had fewer comorbidities, and experienced less postoperative weight loss of > 10%. Females had significantly higher rates of any grade AEs including nausea, abdominal pain, stomatitis, vomiting, and neutropenia, and experienced more grade ≥ 3 neutropenia, nausea, and vomiting. The dose intensity of chemotherapy was significantly lower in females, and they also experienced more frequent dose reduction after the first cycle. Moreover, female patients receiving platinum-containing regimens had significantly higher rates of unscheduled outpatient visits.
Conclusion
Our study found that females experienced a higher incidence of multiple any-grade AEs and severe neutropenia, nausea, and vomiting, across various cancer types, leading to more frequent dose reductions. Physicians should be aware of sex differences in AEs for chemotherapy decisions. -
Citations
Citations to this article as recorded by- Survival benefit of adjuvant chemotherapy for perihilar cholangiocarcinoma: Impact of log odds of metastatic lymph node count
Jun Kawashima, Miho Akabane, Odysseas P. Chatzipanagiotou, Diamantis I. Tsilimigras, Zayed Rashid, Mujtaba Khalil, Abdullah Altaf, Yutaka Endo, Kota Sahara, Federico Aucejo, Hugo P. Marques, Beatriz Chumbinho, Tom Hugh, Shishir K. Maithel, Bas Groot Koerk
Surgery.2026; 191: 109913. CrossRef - Sex-based prognosis in industry-sponsored advanced solid tumor trials: an individual participant data meta-analysis of survival and adverse events
Rakchha Chhetri, Natansh D Modi, Bradley D Menz, Erik Cornelisse, David Postma, Nicole M Kuderer, Gary H Lyman, Sandra M Swain, Lee X Li, Ahmad Y Abuhelwa, Ross A McKinnon, Sina Vatandoust, Ganessan Kichenadasse, Andrew Rowland, Michael J Sorich, Ashley M
JNCI: Journal of the National Cancer Institute.2026; 118(7): 1219. CrossRef - Chemotherapy-Induced Neutropenia in Palestinian Patients with Solid Malignancies: Patient Characteristics, Severity Risk Factors, and Management Patterns
Natalie Khamashta, Ahmad Dalal, Mo’men Alashwas, Musab Hamdan, Fuad Al-Rimawi, Yousef Sahoury
Cancer Research Communications.2026; 6(7): 1714. CrossRef - Developing and Validating a Risk Model for Severe Bone Marrow Suppression in Esophageal Cancer Treated with Radiotherapy or Chemoradiotherapy: A Retrospective Cohort Study
Linlin Guo, Qian Zhang, Mengmei Zhang, Xiaohang Zhong, Yadong Song, Yongcheng Fu, Zhaorui Wang, Haozhe Zhang, Youfu He, Chao Li
Technology in Cancer Research & Treatment.2026;[Epub] CrossRef - Toxicidad del esquema FOLFOX-6, asociado o no a bolo de 5-fluorouracilo, en cáncer colorrectal metastásico
María Teresa Garrido Martínez, María Rodríguez Jorge, Ignacio García Giménez, María Isabel Guzmán Ramos, Salvador Grutzmancher Sáiz, Victoria Aviñó Tarazona
Farmacia Hospitalaria.2025; 49(3): 154. CrossRef - Cancer care for transgender and gender‐diverse people: Practical, literature‐driven recommendations from the Multinational Association of Supportive Care in Cancer
Elizabeth J. Cathcart‐Rake, Alexandre Chan, Alvaro Menendez, Denise Markstrom, Carla Schnitzlein, Yee Won Chong, Don S. Dizon
CA: A Cancer Journal for Clinicians.2025; 75(1): 68. CrossRef - Characterisation of the effects of the chemotherapeutic agent paclitaxel on neuropathic pain-related behaviour, anxiodepressive behaviour, cognition, and the endocannabinoid system in male and female rats
Chiara Di Marino, Álvaro Llorente-Berzal, Alba M. Diego, Ariadni Bella, Laura Boullon, Esther Berrocoso, Michelle Roche, David P. Finn
Frontiers in Pharmacology.2025;[Epub] CrossRef - [Translated article] Toxicity of the FOLFOX-6 regimen, with or without 5-fluorouracil bolus, in metastatic colorectal cancer
María Teresa Garrido Martínez, María Rodríguez Jorge, Ignacio García Giménez, María Isabel Guzmán Ramos, Salvador Grutzmancher Sáiz, Victoria Aviñó Tarazona
Farmacia Hospitalaria.2025; 49(3): T154. CrossRef - The Influence of Tumor Burden Score and Lymph Node Metastasis on the Survival Benefit of Adjuvant Chemotherapy in Intrahepatic Cholangiocarcinoma
Jun Kawashima, Yutaka Endo, Selamawit Woldesenbet, Mujtaba Khalil, Miho Akabane, François Cauchy, Feng Shen, Shishir Maithel, Irinel Popescu, Minoru Kitago, Matthew J. Weiss, Guillaume Martel, Carlo Pulitano, Luca Aldrighetti, George Poultsides, Andrea Ru
Annals of Surgical Oncology.2025; 32(6): 4341. CrossRef - Neurobehavioral manifestations in female rats after intermittent exposure to an anticancer agent, paclitaxel
Deepika Pathak, K.P. Singh
Behavioural Pharmacology.2025; 36(5): 276. CrossRef - Gender‐Affirming Hormone Therapy: Pharmacokinetic Considerations for Oncology in Transgender Patients
Anna Carollo, Lavinia Piazza, Alessio Provenzani
Clinical and Translational Science.2025;[Epub] CrossRef
- Survival benefit of adjuvant chemotherapy for perihilar cholangiocarcinoma: Impact of log odds of metastatic lymph node count
- 6,671 View
- 183 Download
- 10 Web of Science
- 11 Crossref
- Lung and Thoracic cancer
- The Real-World Outcome of First Line Atezolizumab in Extensive-Stage Small Cell Lung Cancer: A Multicenter Prospective Cohort Study
- Myeong Geun Choi, Yeon Joo Kim, Jae Cheol Lee, Wonjun Ji, In-Jae Oh, Sung Yong Lee, Seong Hoon Yoon, Shin Yup Lee, Jeong Eun Lee, Eun Young Kim, Chang-Min Choi
- Cancer Res Treat. 2024;56(2):422-429. Published online October 23, 2023
- DOI: https://doi.org/10.4143/crt.2023.913
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Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
The addition of immune checkpoint inhibitors to chemotherapy has improved survival outcomes in patients with extensive-stage small cell lung cancer (ES-SCLC). However, their real-world effectiveness remains unknown. Therefore, we investigated the effectiveness of atezolizumab plus chemotherapy in ES-SCLC in actual clinical settings.
Materials and Methods
In this multicenter prospective cohort study, patients with ES-SCLC receiving or scheduled to receive atezolizumab in combination with etoposide and carboplatin were enrolled between June 2021 and August 2022. The primary outcomes were progression-free survival (PFS) and the 1-year overall survival (OS) rate.
Results
A total of 100 patients with ES-SCLC were enrolled from seven centers. Median age was 69 years, and 6% had an Eastern Cooperative Oncology Group performance status (ECOG PS) ≥ 2. The median PFS was 6.0 months, the 1-year OS rate was 62.2%, and the median OS was 13.5 months. An ECOG PS of 2-3 and progressive disease as the best response were poor prognostic factors for PFS, while an ECOG PS of 2-3 and brain metastasis were associated with poor prognosis for OS. In addition, consolidative thoracic radiotherapy was found to be an independent favorable prognostic factor for OS (hazard ratio, 0.336; p=0.021). Grade ≥ 3 treatment-related adverse events were observed in 7% of patients, with treatment-related deaths occurring in 2% of patients.
Conclusion
We provided evidence of the favorable real-world effectiveness and safety of atezolizumab plus chemotherapy in ES-SCLC patients, including in the elderly and those with poor ECOG PS. Additional consolidative thoracic radiotherapy may also benefit ES-SCLC patients. -
Citations
Citations to this article as recorded by- Real-World Treatment Patterns and Clinical Outcomes in Patients With Extensive-Stage Small Cell Lung Cancer Treated With First-Line Platinum-Based Chemotherapy and ≥ 2 Subsequent Lines of Therapy in the United States
Kamya Sankar, Sudhir Unni, Marian Eberl, Hoa Le, Tara Herrmann, Boris Gorsh, Mei Tang, Friso Coerts, Sajid Ahmed
Advances in Therapy.2026; 43(1): 214. CrossRef - Atezolizumab in the first-line treatment of small cell lung cancer: Toxicity and safety in real-world clinical practice
Ju. S. Mansurova, M. A. Lyadova, E. A. Denisova, E. S. Kuzmina, V. К. Lyadov
Meditsinskiy sovet = Medical Council.2026; (21): 20. CrossRef - Atezolizumab plus platinum-based chemotherapy and etoposide as first-line treatment for metastatic small cell lung cancer: a retrospective multicenter observational study
Laura Moñino Domínguez, Laura Amaro Álvarez, Alicia Aguado Paredes, Isabel María Carrión Madroñal
Farmacia Hospitalaria.2026;[Epub] CrossRef - Real-World Evidence of Atezolizumab Efficacy as Part of First-Line Treatment for Extensive-Stage SCLC in Bulgaria
Manoela Manova, Boryana Ivanova, Rositsa Krasteva, Nikolay Conev, Tanya Zlatanova, Jeliazko Arabadjiev, Natalia Chilingirova, Mila Petrova, Assen Dudov, Bozhil Robev, Velko Minchev, Ivan Tonev, Krassimir Koynov, Daniel Penchev, Todor Georgiev, Antoan Rang
Cancers.2026; 18(7): 1129. CrossRef - [Artículo traducido] Atezolizumab más quimioterapia con platino y etopósido como tratamiento de primera línea en cáncer de pulmón microcítico metastásico: estudio multicéntrico observacional retrospectivo
Laura Moñino Domínguez, Laura Amaro Álvarez, Alicia Aguado Paredes, Isabel María Carrión Madroñal
Farmacia Hospitalaria.2026;[Epub] CrossRef - First-Line Serplulimab in Extensive-Stage Small Cell Lung Cancer
Jingjing Liu, Liang Han, Lin Wu, Jun Chen, Hongmei Sun, Guilan Wen, Yinghua Ji, Jianhua Shi, Zhijie Pan, Jinsheng Shi, Xicheng Wang, Yuansong Bai, Yueyin Pan, Xuhong Min, Maksym Viguro, Xingya Li, Yanqiu Zhao, Junquan Yang, Tamta Makharadze, Ekaterine Ark
JAMA Oncology.2026;[Epub] CrossRef - Personalized tumor-loaded monocyte-derived dendritic cell vaccination in combination with atezolizumab as maintenance treatment in extensive-stage small cell lung cancer (ES-SCLC): phase Ib-II VENEZOLUNG trial
Maria Gonzalez-Cao, Marta Sisteré-Oró, Teresa Moran, Noemi Reguart, Raquel Cabezon, Andres Aguilar Hernández, Ruth Roman, Miguel A Molina-Vila, Kürşat Birgin, Eva Domenjo-Vila, Gemma Piqué, Miquel Lozano, Paola Charry, Roxana Reyes, Irene Moya, Lluis Cire
Journal for ImmunoTherapy of Cancer.2026; 14(7): e015351. CrossRef - Multicenter retrospective study on the clinical profiles of patients with extensive-stage small-cell lung cancer who met the eligibility criteria for clinical trials
Tatsuya Yazaki, Kei Sonehara, Toshiharu Tsutsui, Shuhei Nozawa, Toshihiko Agatsuma, Manabu Yamamoto, Akemi Matsuo, Masanori Nakanishi, Tomoshige Chiaki, Akane Kato, Takashige Miyahara, Tsutomu Hachiya, Shintaro Kanda, Masayuki Hanaoka
Current Problems in Cancer.2026; 64: 101327. CrossRef - Significance of Platinum‐Based Chemotherapy With Programmed Death‐1 Blockade in Limited Disease Small Cell Lung Cancer: A Retrospective Study
Ayako Shiono, Hisao Imai, Kyoichi Kaira, Takanori Abe, Yuki Sato, Ken Yamamoto, Hiroki Watanabe, Yuko Tsuchiya‐Kawano, Akihiro Tamiya, Takashi Osaki, Noriko Yanagitani, Shigeru Tanzawa, Toshiyuki Sumi, Kohei Yoshimine, Yohei Matsui, Satoshi Endo, Kazuhiko
Thoracic Cancer.2025;[Epub] CrossRef - Impact of Treatment Duration in First-Line Atezolizumab Plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer: A Multicenter Real-World Retrospective Study
Mehmet Nuri Baser, Bilgin Demir, Gamze Serin Ozel, Gamze Gokoz Dogu, Serdar Karakaya, Mucahit Ugar, Naziye Ak, Ahmet Ozveren, Ufuk Camanlı, Olcun Umit Unal, Merve Turan, Esin Oktay
Medicina.2025; 61(7): 1230. CrossRef - Extended Follow‐Up Analysis of First‐Line Atezolizumab in Extensive‐Stage Small Cell Lung Cancer: A Real‐World Multicenter Prospective Cohort Study
Yechan Song, Myeong Geun Choi, Yeon Joo Kim, Jae Cheol Lee, Wonjun Ji, In‐Jae Oh, Sung Yong Lee, Seong Hoon Yoon, Shin Yup Lee, Jeong Eun Lee, Eun Young Kim, Ho Young Kim, Chang‐Min Choi
Thoracic Cancer.2025;[Epub] CrossRef
- Real-World Treatment Patterns and Clinical Outcomes in Patients With Extensive-Stage Small Cell Lung Cancer Treated With First-Line Platinum-Based Chemotherapy and ≥ 2 Subsequent Lines of Therapy in the United States
- 8,410 View
- 314 Download
- 10 Web of Science
- 11 Crossref
- Optimal Definition of Oligometastasis Showing Survival Benefits of Local Therapies during Tyrosine Kinase Inhibitor Treatment
- Yoon Jung Jang, Dong-gon Hyun, Wonjun Ji, Chang-Min Choi, Shinkyo Yoon, Dae Ho Lee, Sang-We Kim, Jae Cheol Lee
- Cancer Res Treat. 2023;55(2):468-478. Published online November 28, 2022
- DOI: https://doi.org/10.4143/crt.2022.1342
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Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
We aimed to investigate the feasibility of four criteria on oligometastasis (OM) concerning clear survival benefits of local therapy (LT) during tyrosine kinase inhibitor (TKI) treatment in non–small cell lung cancer (NSCLC).
Materials and Methods
This single-center, retrospective study included patients with advanced NSCLC who received LT because of OM during TKI treatment at Asan Medical Center from January 2011 to December 2020. At the application of LT OM was classified according to four criteria: TNM, European Organization for Research and Treatment of Cancer Lung Cancer Group (EORTC-LCG), National Comprehensive Network (NCCN), and ORGAN. We compared survival outcomes between patients with and without OM.
Results
The median overall survival of the 117 patients included in the analysis was 70.8 months (95% confidence interval [CI], 56.6 to 85.1). The patients with OM meeting all four criteria (hazard ratio [HR] with 95% CI of TNM criteria 0.24 with 0.10-0.57; p=0.001, EORTC-LCG criteria 0.34 with 0.17-0.67; p=0.002, NCCN criteria 0.41 with 0.20-0.86; p=0.018 and ORGAN criteria 0.33 with 0.18-0.60; p < 0.001) had significantly longer survival compared with patients who did not after adjusting for confounding factors. Furthermore, increasing the number of extra-thoracic metastatic organs to two or more were independent predictive factors for worse survival outcomes (2 organs: HR, 3.51; 95% CI, 1.01 to 12.14; p=0.048; 3 organs: HR, 4.31; 95% CI, 0.94 to 19.73; p=0.060; 4 organs: HR, 24.47; 95% CI, 5.08 to 117.80; p < 0.001).
Conclusion
Patients with OM defined by all four criteria showed prognostic benefits from LT during TKI therapy. -
Citations
Citations to this article as recorded by- The patterns of systemic metastasis in major salivary gland cancer and therapeutic implications
Subi Oh, Younghac Kim, Hyojun Kim, Eunhye Kim, Sook-young Woo, Nayeon Choi, Junhun Cho, Dongryul Oh, Yong-Chan Ahn, Sehhoon Park, Myung-Ju Ahn, Han-Sin Jeong
Oral Oncology.2025; 164: 107258. CrossRef - Surgery for Stage IV Disease—Is It Prime Time Yet?
Marianna V. Papageorge, Mara B. Antonoff
Surgical Oncology Clinics of North America.2025; 34(4): 489. CrossRef
- The patterns of systemic metastasis in major salivary gland cancer and therapeutic implications
- 6,924 View
- 126 Download
- 3 Web of Science
- 2 Crossref
- Real-World Study of Osimertinib in Korean Patients with Epidermal Growth Factor Receptor T790M Mutation–Positive Non–Small Cell Lung Cancer
- Jang Ho Lee, Eun Young Kim, Cheol-Kyu Park, Shin Yup Lee, Min ki Lee, Seong-Hoon Yoon, Jeong Eun Lee, Sang Hoon Lee, Seung Joon Kim, Sung Yong Lee, Jun Hyeok Lim, Tae-Won Jang, Seung Hun Jang, Kye Young Lee, Seung Hyeun Lee, Sei Hoon Yang, Dong Won Park, Chan Kwon Park, Hye Seon Kang, Chang Dong Yeo, Chang-Min Choi, Jae Cheol Lee
- Cancer Res Treat. 2023;55(1):112-122. Published online July 19, 2022
- DOI: https://doi.org/10.4143/crt.2022.381
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Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Although osimertinib is the standard-of-care treatment of epidermal growth factor receptor (EGFR) T790M mutation–positive non–small cell lung cancer, real-world evidence on the efficacy of osimertinib is not enough to reflect the complexity of the entire course of treatment. Herein, we report on the use of osimertinib in patients with EGFR T790M mutation–positive non–small cell lung cancer who had previously received EGFR tyrosine kinase inhibitor (TKI) treatment in Korea.
Materials and Methods
Patients with confirmed EGFR T790M after disease progression of prior EGFR-TKI were enrolled and administered osimertinib 80 mg daily. The primary effectiveness outcome was progression-free survival, with time-to-treatment discontinuation, treatment and adverse effects leading to treatment discontinuation, and overall survival being the secondary endpoints.
Results
A total of 558 individuals were enrolled, and 55.2% had investigator-assessed responses. The median progression-free survival was 14.2 months (95% confidence interval [CI], 13.0 to 16.4), and the median time-to-treatment discontinuation was 15.0 months (95% CI, 14.1 to 15.9). The median overall survival was 36.7 months (95% CI, 30.9 to not reached). The benefit with osimertinib was consistent regardless of the age, sex, smoking history, and primary EGFR mutation subtype. However, hepatic metastases at the time of diagnosis, the presence of plasma EGFR T790M, and the shorter duration of prior EGFR-TKI treatment were poor predictors of osimertinib treatment. Ten patients (1.8%), including three with pneumonitis, had to discontinue osimertinib due to severe adverse effects.
Conclusion
Osimertinib demonstrated its clinical effectiveness and survival benefit for EGFR T790M mutation–positive in Korean patients with no new safety signals. -
Citations
Citations to this article as recorded by- Germ-line exon 21 EGFR V831H mutation in advanced NSCLC resistance to almonertinib: a case report
Daxia Cai, Jian Lou, Yanyan Zhu, Yonghui Wang
Frontiers in Oncology.2026;[Epub] CrossRef - Clinical impact of local consolidative therapy in EGFR-mutant metastatic NSCLC: A propensity-matched multicenter analysis
Eun Hye Lee, Mi-Hyun Kim, Da Hyun Kang, Jisu Moon, Se Hyun Kwak, Jung Seop Eom, Jeong Eun Lee, Chi Young Kim, Yoon Soo Chang, Sang Hoon Lee, Eun Young Kim, Chang Young Lee, Jaeho Cho
Lung Cancer.2026; 217: 109423. CrossRef - Impact of chronic obstructive pulmonary disease on clinical outcomes of EGFR-mutated non–small cell lung cancer patients receiving osimertinib
Chiyo Ishikawa, Yuki Ikematsu, Hiroaki Ogata, Toshifumi Ninomiya, Takahiro Utsumi, Norio Yamamoto, Daisuke Shibahara, Kohei Otsubo, Yoshimasa Shiraishi, Eiji Iwama, Isamu Okamoto
International Journal of Lung Cancer.2026; 1(2): 100032. CrossRef - Osimertinib in EGFR-mutated non-small cell lung cancer: a comprehensive narrative review of clinical evidence
Xiumei Tang, Yuan Zhu, Jiayi Yan, Haoying Wu, Yanmei Chen, Yuan Liu, Huairong Tang, Wenzhao Wang, Zhoufeng Wang
Journal of Translational Genetics and Genomics.2026; 10(2): 228. CrossRef - Molecular testing, treatment patterns, and outcomes in EGFR-mutated non-small cell lung cancer: the PISCES study
Panwen Tian, Lin Wu, Chengzhi Zhou, Jie Tan, Ke Wang, Feng Luo, Yongmei Liu, Yubiao Guo, Yinyin Li, Zhe Liu, Youling Gong, Yongsheng Wang, Jinghong Xian, Weimin Li
Future Oncology.2025; 21(19): 2537. CrossRef - Safety of osimertinib in Chinese patients with non-small cell lung cancer: a multi-center, prospective, observational study
Hua Zhong, Shunjun Jiang, Wenxiu Yao, Xia Song, Dongqing Lv, Dan Zhu, Yubiao Guo, Cuimin Ding, Yingjie Xue, Xiuli Bai, Liguo Xiao, Peifeng Chen, Yan Wang, Panwen Tian, Gen Lin, Wen Li, Jun Chen, Yanping Hu, Bing Xia, Ziping Wang, Hao Long, Weirong Yao, Ha
Future Oncology.2025; 21(28): 3639. CrossRef - Real-world treatment outcomes in South Korean patients with epidermal growth factor receptor-mutant non-small cell lung cancer
Young Saing Kim, Eun Young Lee, Hyun Woo Lee, Jin-Hyuk Choi, Tae-Hwan Kim, Yong Won Choi, Mi Sun Ahn
The Korean Journal of Internal Medicine.2025; 40(6): 1029. CrossRef - The importance of re-biopsy in the era of molecular therapy for lung cancer
Nensi Lalic, Daliborka Bursac, Marko Bojovic, Marko Nemet, Ivan Ergelasev
Srpski arhiv za celokupno lekarstvo.2024; 152(3-4): 209. CrossRef - Detection of EGFR exon 20 insertion mutations in non-small cell lung cancer: implications for consistent nomenclature in precision medicine
Jieun Park, Boram Lee, Ji-Young Song, Minjung Sung, Mi Jeong Kwon, Chae Rin Kim, Sangjin Lee, Young Kee Shin, Yoon-La Choi
Pathology.2024; 56(5): 653. CrossRef - Real‐world study of lazertinib as second‐line or greater treatment in advanced non‐small cell lung cancer
Jeong Uk Lim, Kyuhwan Kim, Kyu Yean Kim, Hye Seon Kang, Ah. Young Shin, Chang Dong Yeo, Sung Kyoung Kim, Chan Kwon Park, Sang Haak Lee, Seung Joon Kim
Thoracic Cancer.2024; 15(19): 1513. CrossRef - Comparative effectiveness of lazertinib in patients with EGFR T790M-positive non-small-cell lung cancer using a real-world external control
Ha-Lim Jeon, Meesong Kwak, Sohee Kim, Hye-Yeon Yu, Ju-Young Shin, Hyun Ae Jung
Scientific Reports.2024;[Epub] CrossRef - A Randomized, Multi-Center, Open Label Study to Compare the Safety and Efficacy between Afatinib Monotherapy and Combination Therapy with HAD-B1 for the Locally Advanced or Metastatic NSCLC Patients with EGFR Mutations
Eunbin Kwag, Soo-Dam Kim, Seong-Hoon Shin, Chulho Oak, So-Jung Park, Jun-Yong Choi, Seong Hoon Yoon, In-Cheol Kang, Mi-Kyung Jeong, Hyun Woo Lee, Sun-Hwi Bang, Ji Woong Son, Sanghun Lee, Seung Joon Kim, Hwa-Seung Yoo
Integrative Cancer Therapies.2024;[Epub] CrossRef - Clinical utility of repeated rebiopsy for EGFR T790M mutation detection in non-small cell lung cancer
Eun Hye Lee, Se Hyun Kwak, Kyeong Yeon Kim, Chi Young Kim, Sang Hoon Lee, Seok-Jae Heo, Yoon Soo Chang, Eun Young Kim
Frontiers in Oncology.2024;[Epub] CrossRef - Real-world evidence of osimertinib in Chinese patients with EGFR T790M-positive non-small cell lung cancer: a subgroup analysis from ASTRIS study
Qing Zhou, He-Long Zhang, Li-Yan Jiang, Yuan-Kai Shi, Yuan Chen, Jin-Ming Yu, Cai-Cun Zhou, Yong He, Yan-Ping Hu, Zong-An Liang, Yue-Yin Pan, Wen-Lei Zhuo, Yong Song, Gang Wu, Gong-Yan Chen, You Lu, Cui-Ying Zhang, Yi-Ping Zhang, Ying Cheng, Shun Lu, Chan
Journal of Cancer Research and Clinical Oncology.2023; 149(12): 10771. CrossRef
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- A Phase I/IIa Randomized Trial Evaluating the Safety and Efficacy of SNK01 Plus Pembrolizumab in Patients with Stage IV Non-Small Cell Lung Cancer
- Eo Jin Kim, Yong-Hee Cho, Dong Ha Kim, Dae-Hyun Ko, Eun-Ju Do, Sang-Yeob Kim, Yong Man Kim, Jae Seob Jung, Yoonmi Kang, Wonjun Ji, Myeong Geun Choi, Jae Cheol Lee, Jin Kyung Rho, Chang-Min Choi
- Cancer Res Treat. 2022;54(4):1005-1016. Published online December 3, 2021
- DOI: https://doi.org/10.4143/crt.2021.986
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
The aim of this study is to evaluate the safety and efficacy of ex vivo activated and expanded natural killer (NK) cell therapy (SNK01) plus pembrolizumab in a randomized phase I/IIa clinical trial.
Materials and Methods
Overall, 18 patients with advanced non–small cell lung cancer (NSCLC) and a programmed death ligand 1 tumor proportion score of 1% or greater who had a history of failed frontline platinum-based therapy were randomized (2:1) to receive pembrolizumab every 3 weeks +/– 6 weekly infusions of SNK01 at either 2×109 or 4×109 cells per infusion (pembrolizumab monotherapy vs. SNK01 combination). The primary endpoint was safety, whereas the secondary endpoints were the objective response rate (ORR), progression-free survival (PFS), overall survival, and quality of life.
Results
Since no dose-limiting toxicity was observed, the maximum tolerated dose was determined as SNK01 4×109 cells/dose. The safety data did not show any new safety signals when SNK01 was combined with pembrolizumab. The ORR and the 1-year survival rate in the NK combination group were higher than those in patients who underwent pembrolizumab monotherapy (ORR, 41.7% vs. 0%; 1-year survival rate, 66.7% vs. 50.0%). Furthermore, the median PFS was higher in the SNK01 combination group (6.2 months vs. 1.6 months, p=0.001).
Conclusion
Based on the findings of this study, the NK cell combination therapy may consider as a safe treatment method for stage IV NSCLC patients who had a history of failed platinum-based therapy without an increase in adverse events. -
Citations
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Journal for ImmunoTherapy of Cancer.2026; 14(1): e013396. CrossRef - NK cell infusion is well-tolerated and shows preliminary efficacy in patients with recurrent hepatocellular carcinoma post-liver transplantation : a phase I trial
Fan Yang, Yihang Gong, Xiaofang Zheng, Beibei Ni, Jianxi Lu, Xiaoyan Chen, Jintao Cheng, Panlong Li, Cong Du, Yunhao Chen, Yingcai Zhang, Shuhong Yi, Guoying Wang, Qi Zhang, Yang Yang, Wenjie Chen
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Alzheimer's Research & Therapy.2025;[Epub] CrossRef - Adopting tomorrow’s therapies today: a perspective review of adoptive cell therapy in lung cancer
Faith Abodunrin, Daniel J Olson, Oluwatosin Emehinola, Christine M Bestvina
Therapeutic Advances in Medical Oncology.2025;[Epub] CrossRef - Preclinical investigation of anti-tumor efficacy of allogeneic natural killer cells combined with cetuximab for head and neck squamous cell carcinoma
Chaeyeon Kim, Mina Han, Gamin Kim, Wonrak Son, Jeongah Kim, Minchan Gil, Yong-Hee Rhee, Nam Suk Sim, Chang Gon Kim, Hye Ryun Kim
Cancer Immunology, Immunotherapy.2025;[Epub] CrossRef - Harnessing Immune Rejuvenation: Advances in Overcoming T Cell Senescence and Exhaustion in Cancer Immunotherapy
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Aging Cell.2025;[Epub] CrossRef - Cytokines in Focus: IL-2 and IL-15 in NK Adoptive Cell Cancer Immunotherapy
Bryan Marr, Donghyeon Jo, Mihue Jang, Seung-Hwan Lee
Immune Network.2025;[Epub] CrossRef - The updated network meta-analysis of the therapeutic efficacies of lung cancer: A systematic review and meta-analysis
Chuan-Hsin Chang, Chih-Cheng Chien, Yue-Cune Chang
Tzu Chi Medical Journal.2025; 37(3): 339. CrossRef - Synergistic Anti-Tumor Efficacy of Modified FOLFIRINOX and NK Cell Therapy in Pancreatic Ductal Adenocarcinoma
Hye-Seong Park, Jun Eul Hwang, Je-Jung Lee, Woo Kyun Bae
Cancers.2025; 17(17): 2785. CrossRef - Machine learning-based development of a cytotoxicity prediction model for NK cell therapy in cancers
Jie Ma, Jingjing Yue, Yangyang Li, Yutong Li, Hongbo Dong, Fang Fang, Weihua Xiao
Cellular Oncology.2025; 48(6): 1837. CrossRef - Efficacy and safety of natural killer cell therapy for the treatment of advanced non-small cell lung cancer: A meta-analysis and systematic review
Zhengnan Li, Xiu’e Wang, Shaoqing Chen, Ping Zhang, Xiujuan Wang, Xinye Ni, Chunlin Mou
Immunologic Research.2025;[Epub] CrossRef - Safety and efficacy of SNK01 (autologous natural killer cells) in combination with cytotoxic chemotherapy and/or cetuximab after failure of prior tyrosine kinase inhibitor in non-small cell lung cancer: non-clinical mouse model and phase I/IIa clinical st
Myeong Geun Choi, Gun Woo Son, Mi Young Choi, Jae Seob Jung, Jin Kyung Rho, Wonjun Ji, Byeong Gon Yoon, Jong-Min Jo, Yong Man Kim, Dae-Hyun Ko, Jae Cheol Lee, Chang-Min Choi
Journal for ImmunoTherapy of Cancer.2024; 12(3): e008585. CrossRef - Disruption of TGF-β signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cells
Jaya Lakshmi Thangaraj, Michael Coffey, Edith Lopez, Dan S. Kaufman
Cell Stem Cell.2024; 31(9): 1327. CrossRef - Strategies to enhance the therapeutic efficacy of anti-PD-1 antibody, anti-PD-L1 antibody and anti-CTLA-4 antibody in cancer therapy
Xin Su, Jian Li, Xiao Xu, Youbao Ye, Cailiu Wang, Guanglong Pang, Wenxiu Liu, Ang Liu, Changchun Zhao, Xiangyong Hao
Journal of Translational Medicine.2024;[Epub] CrossRef - Epigenetic regulation of NKG2D ligand and the rise of NK cell-based immunotherapy for cancer treatment
Raj Kumar, Romi Gupta
Frontiers in Oncology.2024;[Epub] CrossRef - Efficacy and safety of natural killer cell therapy in patients with solid tumors: a systematic review and meta-analysis
Heesook Park, Gyurin Kim, Najin Kim, Sungyoen Ha, Hyeonwoo Yim
Frontiers in Immunology.2024;[Epub] CrossRef - Next-generation immunotherapy: igniting new hope for lung cancer
Molly S. C. Li, Andrew L. S. Chan, Kevin K. S. Mok, Landon L. Chan, Tony S. K. Mok
Therapeutic Advances in Medical Oncology.2024;[Epub] CrossRef - Engineered Cellular Therapies for the Treatment of Thoracic Cancers
Spencer M. Erickson, Benjamin M. Manning, Akhilesh Kumar, Manish R. Patel
Cancers.2024; 17(1): 35. CrossRef - Cellular Therapy in NSCLC: Between Myth and Reality
Martina Imbimbo, Laureline Wetterwald, Alex Friedlaender, Kaushal Parikh, Alfredo Addeo
Current Oncology Reports.2023; 25(10): 1161. CrossRef - NK cell activity and methylated HOXA9 ctDNA as prognostic biomarkers in patients with non-small cell lung cancer treated with PD-1/PD-L1 inhibitors
Sara Witting Christensen Wen, Line Nederby, Rikke Fredslund Andersen, Torben Schjødt Hansen, Christa Haugaard Nyhus, Ole Hilberg, Anders Jakobsen, Torben Frøstrup Hansen
British Journal of Cancer.2023; 129(1): 135. CrossRef - Harnessing Natural Killer Cells for Lung Cancer Therapy
Shoubao Ma, Michael A. Caligiuri, Jianhua Yu
Cancer Research.2023; 83(20): 3327. CrossRef - Natural killer cells: the next wave in cancer immunotherapy
Xin Chen, Lei Jiang, Xuesong Liu
Frontiers in Immunology.2022;[Epub] CrossRef
- Cell therapy in sarcoma: current landscape and future directions
- 16,973 View
- 635 Download
- 25 Web of Science
- 25 Crossref
- Lung Cancer
- Prognostic Factor and Clinical Outcome in Stage III Non-Small Cell Lung Cancer: A Study Based on Real-World Clinical Data in the Korean Population
- Ho Cheol Kim, Wonjun Ji, Jae Cheol Lee, Hyeong Ryul Kim, Si Yeol Song, Chang-Min Choi, Korean Association for Lung Cancer, Korea Central Cancer Registry
- Cancer Res Treat. 2021;53(4):1033-1041. Published online February 16, 2021
- DOI: https://doi.org/10.4143/crt.2020.1350
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
The optimal treatment for patients with stage III non-small cell lung cancer (NSCLC) remains controversial. This study aimed to investigate prognostic factors and clinical outcome in stage III NSCLC using real-world clinical data in the Korean population.
Materials and Methods
Among 8,110 patients with lung cancer selected from 52 hospitals in Korea during 2014-2016, only patients with stage III NSCLC were recruited and analyzed. A standardized protocol was used to collect clinical information and cox proportional hazards models were used to identify risk factors for mortality.
Results
A total of 1,383 patients (46.5% had squamous cell carcinoma and 40.9% had adenocarcinoma) with stage III NSCLC were enrolled, and their median age was 70 years. Regarding clinical stage, 548 patients (39.6%) had stage IIIA, 517 (37.4%) had stage IIIB, and 318 (23.0%) had stage IIIC. Pertaining to the initial treatment method, the surgery group (median survival period: 36 months) showed better survival outcomes than the non-surgical treatment group (median survival period: 18 months, p=0.001) in patients with stage IIIA. Moreover, among patients with stage IIIB and stage IIIC, those who received concurrent chemotherapy and radiation therapy (CCRT, median survival period: 24 months) showed better survival outcomes than those who received chemotherapy (median survival period: 11 months), or radiation therapy (median survival period: 10 months, p<0.001).
Conclusion
While surgery might be feasible as the initial treatment option in patients with stage IIIA NSCLC, CCRT showed a beneficial role in patients with stage IIIB and IIIC NSCLC. -
Citations
Citations to this article as recorded by- Combining the prognostic values of entropy-based heterogeneity features from 18F-fluorodeoxyglucose PET and transmission computed tomography using machine learning in patients with lung adenocarcinoma undergoing curative surgery
Kun-Han Lue, Yu-Hung Chen, Sung-Chao Chu, Chih-Bin Lin, Bee-Song Chang, Pau-Yuan Chang, Shu-Hsin Liu
Nuclear Medicine Communications.2026; 47(4): 479. CrossRef - Development and validation of a novel nomogram model for predicting postoperative survival of T4N0M0 NSCLC: a population-based survival analysis
Tianjian Lu, Nan Chen, Zhe Wang, Weiping Lu
International Journal of Surgery.2026; 112(1): 1139. CrossRef - A long-term survival prediction model for non-small cell lung cancer based on blood inflammatory biomarkers
Yuxia Du, Weihong Qiu, Fei He, Zhibin Zhou, Weimin Ye
Discover Oncology.2026;[Epub] CrossRef - Development and validation of a nomogram for predicting overall survival in primary pulmonary lymphoepithelial carcinoma: a multicenter, large population-based study
Liqiang Wang, Chulan Zhan, Qiying Huang, Haonan Gao, Tong Lin, Jianhui Wu, Jili Zhuang, Xinqing Lin, Maolin Zhou, Shuxi Zhuo, Qingchuang Lin, Lingliang Huang, Ni Sun, Ying Chen, Xiaohong Xie, Chengzhi Zhou
European Journal of Medical Research.2026;[Epub] CrossRef - Incidence Patterns and Prognostic Impact of Lung‐Involving Multiple Primary Cancers: A 10‐Year Hospital‐Based Cohort Study
Hayoung Kim, Jin‐Hee Kwon, Heyjin Kim, Jin Kyung Lee, Young Jun Hong, Hye‐Ryoun Kim
Thoracic Cancer.2026;[Epub] CrossRef - The impact of sarcopenia on short-term efficacy, toxic and adverse reactions, and prognosis in patients with non-small cell lung cancer undergoing concurrent chemoradiotherapy
Yin Yuan, Zhao Yu, Yanchen Ma, Kaining Wang, Jianming Ding, Zelai He, Gengming Wang
Frontiers in Nutrition.2026;[Epub] CrossRef - The value of 18F-FDG PET/CT combined with 3D quantitative technology and clinicopathological features in predicting prognosis of NSCLC
Yuling Su, Siwen Qiu, Jinyu Wang
Frontiers in Oncology.2025;[Epub] CrossRef - Impact of tumor size by clinical N subclassification and histology in trimodality-treated N2 non-small cell lung cancer
Junghee Lee, Jin Lee, Yun Soo Hong, Genehee Lee, Jiyoun Park, Yeong Jeong Jeon, Seong-Yong Park, Jong Ho Cho, Yong Soo Choi, Jhingook Kim, Young Mog Shim, Eliseo Guallar, Juhee Cho, Hong Kwan Kim
Scientific Reports.2025;[Epub] CrossRef - Development and evaluation of tumor-targeting curcumin-loaded magnetic nanoparticles based on PEG-PLGA and transferrin for anti-lung cancer therapy
Gengsheng Shi, Wenqin Yin, Jing Luo, Song Lin, Linluo Zhang, Yuan He, Hui Ding
Materials Today Communications.2025; 47: 113050. CrossRef - Real‐world treatment patterns and clinical outcomes in patients with stage III NSCLC in Korea: The KINDLE study
Jiyun Lee, Hee Kyung Ahn, Sang‐We Kim, Ji‐Youn Han, Sung Sook Lee, Hyung Soon Park, Hyun Woo Lee, Joo‐Hang Kim, Eunhan Cho, Reto Huggenberger, Byoung Chul Cho
Cancer Medicine.2024;[Epub] CrossRef - Contribution of Enhanced Locoregional Control to Improved Overall Survival with Consolidative Durvalumab after Concurrent Chemoradiotherapy in Locally Advanced Non–Small Cell Lung Cancer: Insights from Real-World Data
Jeong Yun Jang, Si Yeol Song, Young Seob Shin, Ha Un Kim, Eun Kyung Choi, Sang-We Kim, Jae Cheol Lee, Dae Ho Lee, Chang-Min Choi, Shinkyo Yoon, Su Ssan Kim
Cancer Research and Treatment.2024; 56(3): 785. CrossRef - Risk factors in depression in oncology patients. Dr. Julio Villacreses Colmont Hospital
Mayra Viviana Zambrano Escobar, Julia Teresa Espinel García
Seminars in Medical Writing and Education.2024; 3: 660. CrossRef - Glucose metabolic heterogeneity correlates with pathological features and improves survival stratification of resectable lung adenocarcinoma
Yu-Hung Chen, Yen-Chang Chen, Kun-Han Lue, Sung-Chao Chu, Bee-Song Chang, Ling-Yi Wang, Ming-Hsun Li, Chih-Bin Lin
Annals of Nuclear Medicine.2023; 37(2): 139. CrossRef - The combined tumor-nodal glycolytic entropy improves survival stratification in nonsmall cell lung cancer with locoregional disease
Yu-Hung Chen, Kun-Han Lue, Sung-Chao Chu, Bee-Song Chang, Chih-Bin Lin
Nuclear Medicine Communications.2023; 44(1): 100. CrossRef - Prognostic value of pretherapeutic FDG PET/CT in non-small cell lung cancer with pulmonary lymphangitic carcinomatosis
Yong-Jin Park, Yunjoo Im, O. Jung Kwon, Joungho Han, Myung-Ju Ahn, Jhingook Kim, Sang-Won Um, Joon Young Choi
Scientific Reports.2023;[Epub] CrossRef - A Propensity-Matched Retrospective Comparative Study with Historical Control to Determine the Real-World Effectiveness of Durvalumab after Concurrent Chemoradiotherapy in Unresectable Stage III Non-Small Cell Lung Cancer
Cheol-Kyu Park, Nakyung Jeon, Hwa-Kyung Park, Hyung-Joo Oh, Young-Chul Kim, Ha-Lim Jeon, Yong-Hyub Kim, Sung-Ja Ahn, In-Jae Oh
Cancers.2023; 15(5): 1606. CrossRef - Association between clinical outcomes and local treatment in stage IV non‐small cell lung cancer patients with single extrathoracic metastasis
Jeong Uk Lim, Hye Seon Kang, Ah Young Shin, Chang Dong Yeo, Chan Kwon Park, Sang Haak Lee, Seung Joon Kim
Thoracic Cancer.2022; 13(9): 1349. CrossRef - Conversion therapy from unresectable stage IIIC non-small-cell lung cancer to radical surgery via anti-PD-1 immunotherapy combined with chemotherapy and anti-angiogenesis: A case report and literature review
Guohua Jia, Shuimei Zhou, Tangpeng Xu, Yabing Huang, Xiangpan Li
Frontiers in Oncology.2022;[Epub] CrossRef - A phase II, multicenter study of lazertinib as consolidation therapy in patients with locally advanced, unresectable, EGFR mutation‐positive non‐small cell lung cancer (stage III) who have not progressed following definitive, platinum‐based, chemoradiatio
Juwhan Choi, Jeong Eun Lee, Chang‐Min Choi, In‐Jae Oh, Kye Young Lee, Tae Won Jang, Seung Hyeun Lee, Eun Young Kim, Dong Won Park, Sun Hyo Park, Sung Yong Lee
Thoracic Cancer.2022; 13(23): 3431. CrossRef - Prognostic Value of Combing Primary Tumor and Nodal Glycolytic–Volumetric Parameters of 18F-FDG PET in Patients with Non-Small Cell Lung Cancer and Regional Lymph Node Metastasis
Yu-Hung Chen, Sung-Chao Chu, Ling-Yi Wang, Tso-Fu Wang, Kun-Han Lue, Chih-Bin Lin, Bee-Song Chang, Dai-Wei Liu, Shu-Hsin Liu, Sheng-Chieh Chan
Diagnostics.2021; 11(6): 1065. CrossRef
- Combining the prognostic values of entropy-based heterogeneity features from 18F-fluorodeoxyglucose PET and transmission computed tomography using machine learning in patients with lung adenocarcinoma undergoing curative surgery
- 12,428 View
- 251 Download
- 20 Web of Science
- 20 Crossref
- Lung cancer
- Active Treatment Improves Overall Survival in Extremely Older Non–Small Cell Lung Cancer Patients: A Multicenter Retrospective Cohort Study
- Su Yeon Lee, Yoon-Ki Hong, Wonjun Ji, Jae Cheol Lee, Chang Min Choi, Korean Association for Lung Cancer, Korea Central Cancer Registry
- Cancer Res Treat. 2021;53(1):104-111. Published online October 5, 2020
- DOI: https://doi.org/10.4143/crt.2020.894
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
As the aging of society progresses, the proportion of extremely older lung cancer patients has also increased; However, studies of these patients with non–small cell lung cancer are limited. Therefore, we investigated the initial treatment modalities and survival outcomes for patients aged 80 years or over.
Materials and Methods
We included a multicenter retrospective cohort from the Korean Association for Lung Cancer Registry, which surveys 10% of the newly diagnosed lung cancer patients across 52 hospitals in Korea. We analyzed and compared the 2014–2016 data of the non–small cell lung cancer patients aged ≥ 80 years and those aged < 80 years.
Results
Of the 6,576 patients reviewed, 780 patients were aged ≥ 80 years, and 5,796 patients were aged < 80 years. In the patients aged ≥ 80 years, surgery and radiation therapy resulted in longer patient survival among those with a resectable tumor (stage I–II) than the best supportive care (median survival, not reached [surgery] vs. 32.2 months [radiation therapy] vs. 11.43 months [best supportive care]). The duration of survival in patients with advanced-stage (IV) lung cancers was higher after chemotherapy than after the best supportive care (median survival, 8.63 months vs. 2.5 months). Patients with stage IV adenocarcinoma who received targeted therapy had better survival than those who did not (median survival, 9.0 months vs. 4.3 months).
Conclusion
Even in extremely older patients, active treatments, such as surgery, radiation therapy, and chemotherapy, can result in better survival outcomes than the best supportive care. -
Citations
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Cancers.2025; 17(12): 2017. CrossRef - The delayed cancer treatment and economic inequality in Korea: results of common cancers by the time-to-surgery
Noorhee Son, Woo-Ri Lee, Dong-Woo Choi, Kyu-Tae Han
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Jeong Uk Lim, Hye Seon Kang, Ah Young Shin, Chang Dong Yeo, Chan Kwon Park, Sang Haak Lee, Seung Joon Kim
Thoracic Cancer.2022; 13(9): 1349. CrossRef - Characteristics and clinical outcomes of patients with nonsmoking small cell lung cancer in Korea
Hye Seon Kang, Jung Uk Lim, Chang Dong Yeo, Chan Kwon Park, Sang Haak Lee, Seung Joon Kim, Ho Cheol Kim, Chang Min Choi, Chi Young Jung, Deog Gon Cho, Jae Hyun Jeon, Jeong Eun Lee, Jin Seok Ahn, Yeongdae Kim, Yoo-Duk Choi, Yang-Gun Suh, Jung-Eun Kim, Youn
BMC Pulmonary Medicine.2022;[Epub] CrossRef
- Changes in Cancer Care for Patients Aged 80 and Above: A Cohort Study from Samsung Comprehensive Cancer Center in South Korea
- 10,365 View
- 165 Download
- 5 Web of Science
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Review Article
- Treatment of Non-small Cell Lung Carcinoma after Failure of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
- Jae Cheol Lee, Seung Hun Jang, Kye Young Lee, Young-Chul Kim
- Cancer Res Treat. 2013;45(2):79-85. Published online June 30, 2013
- DOI: https://doi.org/10.4143/crt.2013.45.2.79
-
Abstract
PDFPubReaderePub
- Since the first description of non-small cell lung cancer (NSCLC) with activating epidermal growth factor receptor (EGFR) mutation as a distinct clinical entity, studies have proved EGFR tyrosine kinase inhibitors (TKIs) as a first choice of treatment. The median response duration of TKIs as a first-line treatment for EGFR mutant tumors ranges from 11 to 14 months. However, acquired resistance to EGFR-TKIs is inevitable due to various mechanisms, such as T790M, c-Met amplification, activation of alternative pathways (IGF-1, HGF, PI3CA, AXL), transformation to mesenchymal cell or small cell features, and tumor heterogeneity. Until development of a successful treatment strategy to overcome such acquired resistance, few options are currently available. Here we provide a summary of the therapeutic options after failure of first line EGFR-TKI treatment for NSCLC.
-
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Tuberculosis and Respiratory Diseases.2017; 80(2): 187. CrossRef - Acquired Resistance to Erlotinib in EGFR Mutation-Positive Lung Adenocarcinoma among Hispanics (CLICaP)
Andrés F. Cardona, Oscar Arrieta, Martín Ignacio Zapata, Leonardo Rojas, Beatriz Wills, Noemí Reguart, Niki Karachaliou, Hernán Carranza, Carlos Vargas, Jorge Otero, Pilar Archila, Claudio Martín, Luis Corrales, Mauricio Cuello, Carlos Ortiz, Luis E. Pino
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