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- Gynecologic cancer
- Nationwide Comparison of Surgical and Oncologic Outcomes in Endometrial Cancer Patients Undergoing Robotic, Laparoscopic, and Open Surgery: A Population-Based Cohort Study
- Kyung-Jin Eoh, Eun-Ji Nam, Sang-Wun Kim, Minkyung Shin, Stella J-H Kim, Jung-Ae Kim, Yong-Tae Kim
- Cancer Res Treat. 2021;53(2):549-557. Published online October 22, 2020
- DOI: https://doi.org/10.4143/crt.2020.802
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Abstract
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Supplementary Material
PubReader
ePub - Purpose
Population-based comparisons between minimally invasive surgery (MIS) (robotic surgery [RS] and laparoscopic surgery [LS]) and open surgery (OS) for managing endometrial cancer are lacking. This study aimed to compare surgical and oncologic outcomes between endometrial cancer patients who underwent surgical staging via MIS or OS.
Materials and Methods
A population-based retrospective cohort study was performed using claims data from the Korean National Health Insurance database from January 2012 to December 2016. All patients who underwent hysterectomy under diagnosis of endometrial cancer were identified. Patients were classified into RS, LS, and OS groups. Operative and oncologic outcomes were compared among the three groups after adjustments for age group, risk group (adjuvant therapy status), modified Charlson comorbidity index, income level, insurance type, and index year using propensity scores obtained via the inverse probability of treatment weighted method.
Results
After adjustment, 5,065 patients (RS, n=315; LS, n=3,248; OS, n=1,503) were analyzed. Patient demographics were comparable. Hospital stay, postoperative complications, and cost were more favorable in the RS and LS groups than in the OS group (all p < 0.001). Five-year overall survival was significantly longer in the RS and LS groups than in the OS group (94.8%, 91.9%, and 86.9%, respectively; p < 0.001). Moreover, the survival benefit of RS was shown in the subgroup analysis of low-risk endometrial cancer patients.
Conclusion
Our study provides further evidence for the RS being a safe surgical alternative to the LS and OS, especially in low-risk endometrial cancer patients, offering surgical and oncologic outcomes equivalent to other surgical approaches. -
Citations
Citations to this article as recorded by
- Robot-assisted pelvic and renal surgery compared with laparoscopic or open surgery: Literature review of cost-effectiveness and clinical outcomes
Thomas Davidson, Rune Sjödahl, Åke Aldman, Claes Lennmarken, Ann-Sofi Kammerlind, Elvar Theodorsson
Scandinavian Journal of Surgery.2024; 113(1): 13. CrossRef - Progress of Research on the Application of Robotic Surgical System in Gynecologic Malignancies
璐 余
Advances in Clinical Medicine.2024; 14(03): 327. CrossRef - Sociodemographic, clinical characteristics, and treatment patterns of endometrial cancer cases in Puerto Rico during the period 2009 to 2015: A retrospective study
Yisel Pagán Santana, Maira Castañeda Ávila, Ruth Ríos Motta, Karen J. Ortiz Ortiz, Asmerom Tesfamariam Sengal
PLOS ONE.2024; 19(5): e0302253. CrossRef - Comparison of Long-Term Outcomes in Early-Stage Endometrial Cancer: Robotic Single-Site vs. Multiport Laparoscopic Surgery
Heeju Kang, Hyewon Chung, Seungmee Lee, Tae-Kyu Jang, So-Jin Shin, Sang-Hoon Kwon, Chi-Heum Cho
Journal of Personalized Medicine.2024; 14(6): 601. CrossRef - Impact of Robotic Assistance on Minimally Invasive Surgery for Type II Endometrial Cancer: A National Cancer Database Analysis
Kelly Lamiman, Michael Silver, Nicole Goncalves, Michael Kim, Ioannis Alagkiozidis
Cancers.2024; 16(14): 2584. CrossRef - Clinical Relevance of Uterine Manipulation on Oncologic Outcome in Robot-Assisted versus Open Surgery in the Management of Endometrial Cancer
Kyung Jin Eoh, Yoo-Na Kim, Eun Ji Nam, Sang Wun Kim, Young Tae Kim
Journal of Clinical Medicine.2023; 12(5): 1950. CrossRef - Trend and characteristics of minimally invasive surgery for patients with endometrial cancer in Japan
Hiroshi Yoshida, Hiroko Machida, Koji Matsuo, Yoshito Terai, Takuma Fujii, Masaki Mandai, Kei Kawana, Hiroaki Kobayashi, Mikio Mikami, Satoru Nagase
Journal of Gynecologic Oncology.2023;[Epub] CrossRef - Clinical Relevance of Red Blood Cell Distribution Width (RDW) in Endometrial Cancer: A Retrospective Single-Center Experience from Korea
Kyung-Jin Eoh, Tae-Kyung Lee, Eun-Ji Nam, Sang-Wun Kim, Young-Tae Kim
Cancers.2023; 15(15): 3984. CrossRef - Robot-Assisted Surgery in the Treatment of Gynecological Carcinoma and Malignancies: Introduction to the da Vinci Robotic Surgery System
Arnav Goel, Soumya Pamnani, Ashish Anjankar
Cureus.2023;[Epub] CrossRef - Robot-assisted versus conventional laparoscopic surgery for endometrial cancer: long-term comparison of outcomes
Kyung Jin Eoh, Tae-Joong Kim, Jeong-Yeol Park, Hee Seung Kim, Jiheum Paek, Young Tae Kim
Frontiers in Oncology.2023;[Epub] CrossRef - Comparison of Single-Port Laparoscopy with Other Surgical Approaches in Endometrial Cancer Surgical Staging: Propensity-Score-Matched Analysis
Sang Hyun Cho, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Young Tae Kim, Sang Wun Kim
Cancers.2023; 15(22): 5322. CrossRef - Short-Term Outcome of Robotic versus Laparoscopic Hysterectomy for Endometrial Cancer in Women with Diabetes: Analysis of the US Nationwide Inpatient Sample
Huang-Pin Shen, Chih-Jen Tseng
Journal of Clinical Medicine.2023; 12(24): 7713. CrossRef - Laparoscopic vs. open procedure for intermediate‑ and high‑risk endometrial cancer: a minimum 4-year follow-up analysis
Xing Zhou, Sitian Wei, Qingchun Shao, Jun Zhang, Rong Zhao, Rui Shi, Wei Zhang, Kejun Dong, Wan Shu, Hongbo Wang
BMC Cancer.2022;[Epub] CrossRef - Oncologic safety of laparoscopic surgery for women with apparent early‐stage uterine serous carcinoma: A multi‐institutional retrospective cohort study
Yu Xu, Juan Shen, Qianwen Zhang, Yuedong He, Cheng Chen, Yong Tian
International Journal of Gynecology & Obstetrics.2022; 158(1): 162. CrossRef - Impact of lymphadenectomy on short- and long-term complications in patients with endometrial cancer
Louisa Proppe, Ibrahim Alkatout, Ricarda Koch, Sascha Baum, Christos Kotanidis, Achim Rody, Lars C. Hanker, Georgios Gitas
Archives of Gynecology and Obstetrics.2022; 306(3): 811. CrossRef - Survival Analysis in Endometrial Carcinomas by Type of Surgical Approach: A Matched-Pair Study
Pluvio J. Coronado, Agnieszka Rychlik, Laura Baquedano, Virginia García-Pineda, Maria A. Martínez-Maestre, Denis Querleu, Ignacio Zapardiel
Cancers.2022; 14(4): 1081. CrossRef - Robot-assisted versus laparoscopic minimally invasive surgery for the treatment of stage I endometrial cancer
Peter A. Argenta, Jordan Mattson, Colleen L. Rivard, Elizabeth Luther, Alexandra Schefter, Rachel I. Vogel
Gynecologic Oncology.2022; 165(2): 347. CrossRef - Effects of Quantitative Nursing Combined with Psychological Intervention in Operating Room on Stress Response, Psychological State, and Prognosis of Patients Undergoing Laparoscopic Endometrial Cancer Surgery
Xiaojing Chen, Huiyan Li, Shouyan Wang, Yu Wang, Li Zhang, Dandan Yao, Li Li, Ge Gao, Shakeel Ahmad
Computational and Mathematical Methods in Medicine.2022; 2022: 1. CrossRef - Increased HSF1 Promotes Infiltration and Metastasis in Cervical Cancer via Enhancing MTDH-VEGF-C Expression
Xueyan Shi, Zhenghao Deng, Shouman Wang, Shuai Zhao, Lan Xiao, Jiang Zou, Tao Li, Sichuang Tan, SipAin Tan, Xianzhong Xiao
OncoTargets and Therapy.2021; Volume 14: 1305. CrossRef - Surgical and Patient Outcomes of Robotic Versus Conventional Laparoscopic Hysterectomy: A Systematic Review
Khadija Alshowaikh, Katarzyna Karpinska-Leydier, Jashvini Amirthalingam , Gokul Paidi, Anuruddhika I Iroshani Jayarathna, Divya Bala Anthony Manisha R Salibindla, Huseyin Ekin Ergin
Cureus.2021;[Epub] CrossRef - Surgical outcomes of robotic-assisted surgery in endometrial cancer:comparison with laparoscopic surgery and laparotomy
Yoshitsugu Chigusa, Sae Yu, Naoki Horikawa, Haruko Okamoto, Masumi Sunada, Ukita Masayo, Koji Yamanoi, Ken Yamaguchi, Akihito Horie, Masaki Mandai
JAPANESE JOURNAL OF GYNECOLOGIC AND OBSTETRIC ENDOSCOPY.2021; 37(2): 10. CrossRef
- Robot-assisted pelvic and renal surgery compared with laparoscopic or open surgery: Literature review of cost-effectiveness and clinical outcomes
- 7,255 View
- 218 Download
- 20 Web of Science
- 21 Crossref
- Analysis of BRIP1 Variants among Korean Patients with BRCA1/2 Mutation-Negative High-Risk Breast Cancer
- Haeyoung Kim, Dae-Yeon Cho, Doo Ho Choi, Gee Hue Jung, Inkyung Shin, Won Park, Seung Jae Huh, Seok Jin Nam, Jeong Eon Lee, Won Ho Gil, Seok Won Kim
- Cancer Res Treat. 2016;48(3):955-961. Published online January 19, 2016
- DOI: https://doi.org/10.4143/crt.2015.191
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Abstract
PDFPubReaderePub
- Purpose
The aim of the current study is to assess the spectrum of genetic variation in the BRIP1 gene among Korean high-risk breast cancer patients who tested negative for the BRCA1/2 mutation.
Materials and Methods
Overall, 235 Korean patientswith BRCA1/2 mutation–negative high-risk breast cancerwere screened for BRIP1 mutations. The entire BRIP1 gene was analyzed using fluorescent-conformation sensitive gel electrophoresis. In silico analysis of BRIP1 variants was performed using PolyPhen-2 and SIFT.
Results
A total of 20 sequence alterations including 12 exonic and eight intronic variantswere found. Among the 12 exonic variants, 10 were missense and two were silent mutations. No protein-truncating mutation was found among the tested patients. Among the 10 missense variants, four (p.L263F, p.L340F, p.L474P, and p.R848H) were predicted to be pathogenic by both PolyPhen-2 and SIFT, and these variants were found in five patients. Of the four missense variants, p.L263F, p.L474P, and p.R848H localize to regions between the helicase motifs, while p.L340F resides in an iron-sulfur domain of BRIP1.
Conclusion
No protein-truncating mutation in BRIP1 was found among the tested patients. The contribution of BRIP1 variants is thought to be minor in Korean non-BRCA1/2 high-risk breast cancer. -
Citations
Citations to this article as recorded by- Identification of pathogenic germline variants in a large Chinese lung cancer cohort by clinical sequencing
Zhe Yu, Zirui Zhang, Jun Liu, Xiaoying Wu, Xiaojun Fan, Jiaohui Pang, Hua Bao, Jiani Yin, Xue Wu, Yang Shao, Zhengcheng Liu, Fang Liu
Molecular Oncology.2024; 18(5): 1301. CrossRef - Iron–Sulfur Clusters: Assembly and Biological Roles
Nunziata Maio
Inorganics.2024; 12(8): 216. CrossRef - Evaluation of 17 genetic variants in association with leukemia in the north Indian population using MassARRAY Sequenom
Amrita Bhat, Gh. Rasool Bhat, Sonali Verma, Bhanu Sharma, Divya Bakshi, Deepak Abrol, Supinder Singh, Raies Ahmed Qadri, Ruchi Shah, Rakesh Kumar
Journal of Biochemical and Molecular Toxicology.2021;[Epub] CrossRef - Cancer-associated mutations in the iron-sulfur domain of FANCJ affect G-quadruplex metabolism
Diana C. Odermatt, Wei Ting C. Lee, Sebastian Wild, Stanislaw K. Jozwiakowski, Eli Rothenberg, Kerstin Gari, Andrew Deans
PLOS Genetics.2020; 16(6): e1008740. CrossRef - Helicase-inactivating BRIP1 mutation yields Fanconi anemia with microcephaly and other congenital abnormalities
Lara Kamal, Sarah B. Pierce, Christina Canavati, Amal Abu Rayyan, Tamara Jaraysa, Orit Lobel, Suhair Lolas, Barbara M. Norquist, Grace Rabie, Fouad Zahdeh, Ephrat Levy-Lahad, Mary-Claire King, Moien N. Kanaan
Molecular Case Studies.2020; 6(5): a005652. CrossRef - Variants of cancer susceptibility genes in Korean BRCA1/2 mutation-negative patients with high risk for hereditary breast cancer
Ji Soo Park, Seung-Tae Lee, Eun Ji Nam, Jung Woo Han, Jung-Yun Lee, Jieun Kim, Tae Il Kim, Hyung Seok Park
BMC Cancer.2018;[Epub] CrossRef - Mutation status of RAD51C,PALB2 and BRIP1 in 100 Japanese familial breast cancer cases without BRCA1 and BRCA2 mutations
Katsutoshi Sato, Mio Koyasu, Sachio Nomura, Yuri Sato, Mizuho Kita, Yuumi Ashihara, Yasue Adachi, Shinji Ohno, Takuji Iwase, Dai Kitagawa, Eri Nakashima, Reiko Yoshida, Yoshio Miki, Masami Arai
Cancer Science.2017; 108(11): 2287. CrossRef - Mutational analysis of FANCJ helicase
Manhong Guo, Venkatasubramanian Vidhyasagar, Tanu Talwar, Ahmad Kariem, Yuliang Wu
Methods.2016; 108: 118. CrossRef
- Identification of pathogenic germline variants in a large Chinese lung cancer cohort by clinical sequencing
- 14,095 View
- 240 Download
- 8 Web of Science
- 8 Crossref
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