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Original Article
Impact of Pulmonary Tuberculosis on the EGFR Mutational Status and Clinical Outcome in Patients with Lung Adenocarcinoma
In Kyoung Hwang, Seung Sook Paik, Seung Hyeun Lee
Cancer Res Treat. 2019;51(1):158-168.   Published online April 2, 2018
DOI: https://doi.org/10.4143/crt.2018.084
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Although it has been suggested that pulmonary tuberculosis (TB) is associated with increased risk of lung cancer, the exact mechanism is not clearly identified. We investigated the effect of pulmonary TB on the epidermal growth factor receptor (EGFR) mutational status and clinical outcome in patients with pulmonary adenocarcinoma.
Materials and Methods
We reviewed data of patients diagnosed with pulmonary adenocarcinoma harboring EGFR mutations and treated at our institution from 2008 to 2015. We divided our population into two groups: patients with pre-existing TB lesions on chest computed tomography scan (TB group) and those without the lesions (non-TB group). We compared the differences in EGFR mutational status, response to tyrosine kinase inhibitors (TKIs) and survival between the two groups.
Results
A total of 477 patients with pulmonary adenocarcinoma were analyzed. One hundred eighty-three patients (39%) had EGFR-mutated tumors and 100 (21%) patients had pre-existing TB lesions. The frequency of EGFR mutation was significantly higher in the TB group compared with the non-TB group (56% vs. 34%, p=0.038). Pre-existing TB lesions were independently associated with more frequent EGFR mutations in multivariate analysis (odds ratio, 1.43). In addition, both the progression-free survival (9.1 months vs. 11.6 months, p=0.020) and the overall survival (19.4 months vs. 24.5 months, p=0.014) after first-line EGFR-TKIs were significantly shorter in the TB group than in the non-TB group.
Conclusion
Previous pulmonary TB may be associated with more frequent EGFR mutations and poorer treatment response to EGFR-TKIs in patients with pulmonary adenocarcinoma.

Citations

Citations to this article as recorded by  
  • A DNA Methylation Signature From Buccal Swabs to Identify Tuberculosis Infection
    Lovisa Karlsson, Isabelle Öhrnberg, Shumaila Sayyab, David Martínez-Enguita, Mika Gustafsson, Patricia Espinoza, Melissa Méndez-Aranda, Cesar Ugarte-Gil, Lameck Diero, Ronald Tonui, Jakob Paues, Maria Lerm
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  • Contagious illness of tuberculosis and correlation with various types of cancer
    Karthikeyan Sundaram, Venkataraman Prabhu
    Medicine in Microecology.2025; 24: 100123.     CrossRef
  • Coexistent Pulmonary Tuberculosis and Lung Cancer: An Analysis of Incidence Trends, Financial Burdens and Influencing Factors
    Fei Qi, Hongjie Yang, Yi Han, Yujie Dong, Fan Zhang, Yishuo Wang, Juan Du, Yuan Gao, Xueguang Hu, Liqun Zhang, Tongmei Zhang
    Cancer Innovation.2025;[Epub]     CrossRef
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    Chuan Wang, Rong-Qi Zou, Guo-Zhong He
    Frontiers in Immunology.2024;[Epub]     CrossRef
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    G. M. Agafonov, G. G. Kudriashov, U. S. Krylova, T. S. Zubareva, I. M. Kvetnoy, P. K. Yablonskiy
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  • Quantitative analysis of cell-free DNA by droplet digital PCR reveals the presence of EGFR mutations in non-malignant lung pathologies
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    Monaldi Archives for Chest Disease.2021;[Epub]     CrossRef
  • Concomitant Pulmonary Tuberculosis Impair Survival in Advanced Epidermal Growth Factor Receptor (EGFR) Mutant Lung Adenocarcinoma Patients Receiving EGFR-Tyrosine Kinase Inhibitor
    Yalin Xie, Ning Su, Wei Zhou, An Lei, Xiang Li, Weiwei Li, Zhan Huang, Wenchang Cen, Jinxing Hu
    Cancer Management and Research.2021; Volume 13: 7517.     CrossRef
  • A Case of Delayed Diagnostic Pulmonary Tuberculosis during Targeted Therapy in an EGFR Mutant Non-Small Cell Lung Cancer Patient
    Caibao Jin, Bin Yang
    Case Reports in Oncology.2021; 14(1): 659.     CrossRef
  • Follow‐up of an occult tuberculosis scar cancer after resection of metastatic lesions
    Mengyao Sun, Yinghui Xu, Xu Wang, Chao Sun, Ye Guo, Guoguang Shao, Zhiguang Yang, Yunpeng Liu, Peng Zhang, Shi Qiu, Kewei Ma
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Special Articles
Nationwide Cancer Incidence in Korea, 2003-2005
Young-Joo Won, Joohon Sung, Kyu-Won Jung, Hyun-Joo Kong, Sohee Park, Hai-Rim Shin, Eun-Cheol Park, Yoon-Ok Ahn, In Kyoung Hwang, Duk-Hee Lee, Jin-Su Choi, Woo-Cheol Kim, Tae-Yong Lee, Cheol-In Yoo, Jong-Myon Bae, Ok-Nam Kim, Woojin Chung, In-Sik Kong, Duk-Hyoung Lee, Jin-Soo Lee
Cancer Res Treat. 2009;41(3):122-131.   Published online September 28, 2009
DOI: https://doi.org/10.4143/crt.2009.41.3.122
AbstractAbstract PDFPubReaderePub
Purpose

To estimate the current cancer burden in Korea, newly diagnosed cancer cases and cancer incidence rates were calculated for the years 2003~2005.

Materials and Methods

The cancer incidence cases and rates were calculated from the Korea National Cancer Incidence Database. Crude and age-standardized incidence rates were calculated by gender for specified cancer sites in 5-year age groups.

Results

From 2003 to 2005, 398,824 cases of cancer were newly diagnosed in Korea (218,856 in men and 179,968 in women). For all sites combined, the crude incidence rate (CR) was 300.0 and 248.2 for men and women and the age-standardized incidence rate (ASR) was 297.0 and 191.2 per 100,000, respectively. Among men, five leading cancers were stomach (CR 66.0, ASR 64.2), lung (CR 48.5, ASR 50.3), liver (CR 44.9, ASR 42.1), colon and rectum (CR 37.9, ASR 37.2), and prostate cancer (CR 12.7, ASR 13.8). Among women, five leading cancers were breast (CR 37.3, ASR 29.0), thyroid (CR 36.2, ASR 28.8), stomach (CR 34.1, ASR 25.4), colon and rectum (CR 28.0, ASR 21.1), and lung cancer (CR 17.9, ASR 12.8). In the 0~14-year-old group, leukemia was the most common in both sexes; in the 15~34 group, the most common cancer was stomach cancer for men and thyroid cancer for women; in the 35~64 group, stomach cancer for men and breast cancer for women; among those 65 and over, lung cancer for men and stomach cancer, for women, respectively.

Conclusion

The cancer incidence rates have increased in recent years, and more cancers are expected to develop as Korea is quickly becoming an aged society. The cancer incidence statistics in this report can be used as an important source to effectively plan and evaluate the cancer control program in Korea.

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National Cancer Incidence for the Year 2002 in Korea
Hai-Rim Shin, Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Seon-Hee Yim, Joohon Sung, Sun-Won Seo, Ki-Young Kim, Sang-Yi Lee, In-Sik Kong, In Kyoung Hwang, Choong Won Lee, Ze-Hong Woo, Tae-Yong Lee, Jin-Su Choi, Cheol-In Yoo, Jong-Myon Bae, Keun-Young Yoo
Cancer Res Treat. 2007;39(4):139-149.   Published online December 31, 2007
DOI: https://doi.org/10.4143/crt.2007.39.4.139
AbstractAbstract PDFPubReaderePub
Purpose

Since the revised Cancer Act of October 2006, cancer registration was reactivated, based on the Statistics Law.

Materials and Methods

The incidence of cancer during 2002 was calculated on the basis of the information available from the National Cancer Incidence Database. Crude and age-standardized rates were calculated by gender for 18 age groups (0~4, 5~9, 10~14, every five years, 85 years and over).

Results

The overall crude incidence rates (CRs) were 269.2 and 212.8 per 100,000 for males and females, and the overall age-standardized incidence rates (ASRs) were 287.8 and 172.9 per 100,000, respectively. Among males, the five leading primary cancer sites were stomach (CR 62.4, ASR 65.7), lung (CR 45.4, ASR 51.0), liver (CR 43.2, ASR 43.7), colon and rectum (CR 30.7, ASR 32.7), and prostate (CR 8.0, ASR 9.6). Among females, the most common cancer sites were breast (CR 33.1, ASR 26.9), followed by stomach (CR 32.8, ASR 26.0), colon and rectum (CR 23.1, ASR 18.5), thyroid (CR 19.1, ASR 15.7), and uterine cervix (CR 18.2, ASR 14.7). In the 0~14 age group, leukemia was the most common cancer for both genders. For males, stomach cancer was the most common cancer in the 15~64 age-group, but lung cancer was more frequent in men 65 or older. For females, thyroid cancer among the 15~34 age-group, breast cancer among 35~64 age-group and stomach cancer in women 65 years or older were the most common forms of cancer for each age group. The quality indices for the percentage of deaths, by death certificate only, were 4.7% for males and 4.5% for females.

Conclusions

Since the National Cancer Incidence Database was started, the annual percent change of cancer cases increased by 4.8% (4.1% for males, 5.7% for females) during 1999~2002. This value reflects the increase in prostate cancer for males and breast and thyroid cancer in females during 2002. The timely reporting of improved quality of cancer registration is needed for evidence-based decisions regarding cancer control in Korea.

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  • Effect ofHelicobacter pyloriEradication on Subsequent Dysplasia Development after Endoscopic Resection of Gastric Dysplasia
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  • Thyroid Cancer is the Most Common Cancer in Women, Based on the Data from Population-based Cancer Registries, South Korea
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  • Clinico-epigenetic combination including quantitative methylation value of DKK3 augments survival prediction of the patient with cervical cancer
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    Journal of Cancer Research and Clinical Oncology.2013; 139(1): 97.     CrossRef
  • Reduced Expression of DKK3 Is Associated With Adverse Clinical Outcomes of Uterine Cervical Squamous Cell Carcinoma
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    International Journal of Gynecological Cancer.2013; 23(1): 134.     CrossRef
  • Genetic Alterations of K-ras, p53, c-erbB-2, and DPC4 in Pancreatic Ductal Adenocarcinoma and Their Correlation With Patient Survival
    Sang Hyun Shin, Song Cheol Kim, Seung-Mo Hong, Young Hoon Kim, Ki-Byung Song, Kwang-Min Park, Young-Joo Lee
    Pancreas.2013; 42(2): 216.     CrossRef
  • Comparing Endoscopy and Upper Gastrointestinal X-ray for Gastric Cancer Screening in South Korea: A Cost-utility Analysis
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    Asian Pacific Journal of Cancer Prevention.2012; 13(6): 2721.     CrossRef
  • Health and Economic Burden of Major Cancers Due to Smoking in Korea
    In-Hwan Oh, Seok-Jun Yoon, Tai-Young Yoon, Joong-Myung Choi, Bong-Keun Choe, Eun-Jung Kim, Young-Ae Kim, Hye-Young Seo, Yoon-Hyung Park
    Asian Pacific Journal of Cancer Prevention.2012; 13(4): 1525.     CrossRef
  • Cancer Control in the Asia Pacific Region: Current Status and Concerns
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  • Comparison of Surgical Outcomes between Robotic and Laparoscopic Gastrectomy for Gastric Cancer: The Learning Curve of Robotic Surgery
    Byung Hee Kang, Yi Xuan, Hoon Hur, Chang Wook Ahn, Yong Kwan Cho, Sang-Uk Han
    Journal of Gastric Cancer.2012; 12(3): 156.     CrossRef
  • Clinical Guidelines for the Treatment and Prevention of Opportunistic Infections in HIV-infected Koreans

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  • The comparison of clinicopathological characteristics in primary malignant mixed műllerian tumour with epithelial endometrial carcinoma
    Seo‐Yun TONG, Jong‐Min LEE, Young‐Joon CHOI, Jae‐Kwan LEE, Jao Weon KIM, Chi‐Heum CHO, Seok‐Mo KIM, Sang‐Yoon PARK, Chan‐Yong PARK, Ki‐Tae KIM
    Australian and New Zealand Journal of Obstetrics and Gynaecology.2012; 52(1): 44.     CrossRef
  • A Population-Based Cohort Study of HRT Use and Breast Cancer in Korea
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    Asia Pacific Journal of Public Health.2012; 24(2): 415.     CrossRef
  • CYP2A6 and ERCC1 polymorphisms correlate with efficacy of S-1 plus cisplatin in metastatic gastric cancer patients
    S R Park, S-Y Kong, B-H Nam, I J Choi, C G Kim, J Y Lee, S J Cho, Y W Kim, K W Ryu, J H Lee, J Rhee, Y-I Park, N K Kim
    British Journal of Cancer.2011; 104(7): 1126.     CrossRef
  • Correlation between immunocytochemistry of human papilloma virus L1 capsid protein and behavior of low‐grade cervical cytology in Korean women
    Sung Jong Lee, Ah Won Lee, Tae Jung Kim, Jin Hwi Kim, Jeong Hoon Bae, Chung Won Lee, Min Jong Song, Joo Hee Yoon, Soo Young Hur, Jong Sup Park
    Journal of Obstetrics and Gynaecology Research.2011; 37(9): 1222.     CrossRef
  • p53 codon 72 polymorphism and the risk of lung cancer in a Korean population
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    Lung Cancer.2011; 73(3): 264.     CrossRef
  • Increasing Nodal Ratio is a Poor Prognostic Factor for Survival in Stage III-IV (M0) Gastric Cancer Patients Who Received Curative Surgery Followed by Adjuvant Chemotherapy: A Retrospective Study
    J.-S. Kim, M.-A. Kim, D.-Y. Oh, S.-H. Lee, D.-W. Kim, S.-A. Im, W. H. Kim, H.-K. Yang, D. S. Heo, Y.-J. Bang, K.-U. Lee, T.-Y. Kim
    Japanese Journal of Clinical Oncology.2011; 41(2): 245.     CrossRef
  • Inequalities in adoption of cancer screening from a diffusion of innovation perspective: Identification of late adopters
    Myung-Il Hahm, Eun-Cheol Park, Kui Son Choi, Hoo-Yeon Lee, Jae-Hyun Park, Sohee Park
    Cancer Epidemiology.2011; 35(1): 90.     CrossRef
  • Phase II study of a triplet regimen of S-1 combined with irinotecan and oxaliplatin in patients with metastatic gastric cancer: clinical and pharmacogenetic results
    S.R. Park, S.-Y. Kong, J. Rhee, Y.-I. Park, K.W. Ryu, J.H. Lee, Y.-W. Kim, I.J. Choi, C.G. Kim, J.Y. Lee, S.-J. Cho, N.K. Kim
    Annals of Oncology.2011; 22(4): 890.     CrossRef
  • Phase II study of vinorelbine monotherapy in anthracycline and taxane pre-treated metastatic breast cancer
    Hee Yeon Seo, Hyun Joo Lee, Ok Hee Woo, Kyong Hwa Park, Sang Uk Woo, Dae Sik Yang, Ae-Ree Kim, Jae-Bok Lee, Eun Sook Lee, Yeul Hong Kim, Jun Suk Kim, Jae Hong Seo
    Investigational New Drugs.2011; 29(2): 360.     CrossRef
  • The peak‐standardized uptake value (P‐SUV) by preoperative positron emission tomography‐computed tomography (PET‐CT) is a useful indicator of lymph node metastasis in gastric cancer
    Hyeon Hwa Oh, Sang Eok Lee, In Seok Choi, Won Jun Choi, Dae Sung Yoon, Hyun Sik Min, Yu Mi Ra, Ju Ik Moon, Yun Hee Kang
    Journal of Surgical Oncology.2011; 104(5): 530.     CrossRef
  • No Association between PIK3CA Polymorphism and Lung Cancer Risk in the Korean Population
    Jae-Sook Sung, Kyong-Hwa Park, Seung-Tae Kim, Jae-Hong Seo, Sang-Won Shin, Jun-Suk Kim, Yeul-Hong Kim
    Genomics & Informatics.2010; 8(4): 194.     CrossRef
  • Genome‐wide identification of chemosensitive single nucleotide polymorphism markers in colorectal cancers
    Jin C. Kim, Seon Y. Kim, Dong H. Cho, Seon A. Roh, Eun Y. Choi, Yoon K. Jo, Sang H. Jung, Young S. Na, Tae W. Kim, Yong S. Kim
    Cancer Science.2010; 101(4): 1007.     CrossRef
  • Incidence, Epidemiology and Patterns of Progression of Prostate Cancer
    Se Joong Kim, Sun Il Kim
    Journal of the Korean Medical Association.2010; 53(2): 92.     CrossRef
  • Dietary Intake of Nitrate Relative to Antioxidant Vitamin in Relation to Breast Cancer Risk: A Case-Control Study
    Yoon Jung Yang, Se Hee Hwang, Hyun Ja Kim, Seok-Jin Nam, Gu Kong, Mi Kyung Kim
    Nutrition and Cancer.2010; 62(5): 555.     CrossRef
  • Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin
    Yoo Ri Kim, Ji Eun Oh, Min Sung Kim, Mi Ran Kang, Sang Wook Park, Ji Youn Han, Hyeon Seok Eom, Nam Jin Yoo, Sug Hyung Lee
    The Journal of Pathology.2010; 220(4): 446.     CrossRef
  • Genomic alterations of chromosome region 11p as predictive marker by array comparative genomic hybridization in lung adenocarcinoma patients
    Jae Sook Sung, Kyong Hwa Park, Yeul Hong Kim
    Cancer Genetics and Cytogenetics.2010; 198(1): 27.     CrossRef
  • Clinical Outcomes and Prognostic Factors of Metastatic Gastric Carcinoma Patients Who Experience Gastrointestinal Perforation During Palliative Chemotherapy
    Myoung Hee Kang, Shi Nae Kim, Noe Kyeong Kim, Young-Iee Park, Young-Woo Kim, Keun Won Ryu, Jun Ho Lee, Jong Seok Lee, Sook Ryun Park
    Annals of Surgical Oncology.2010; 17(12): 3163.     CrossRef
  • Combined effect of socioeconomic status, viral hepatitis, and lifestyles on hepatocelluar carcinoma risk in Korea
    E H Yun, M K Lim, J-K Oh, J H Park, A Shin, J Sung, E-C Park
    British Journal of Cancer.2010; 103(5): 741.     CrossRef
  • Efficacy of human papillomavirus vaccines including cross protection : A review of recent evidence
    Chan Joo Kim, Tae Chul Park, Jong Sup Park
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  • Prognostic Value of Preoperative Clinical Staging Assessed by Computed Tomography in Resectable Gastric Cancer Patients
    Sook Ryun Park, Min Ju Kim, Keun Won Ryu, Jun Ho Lee, Jong Seok Lee, Byung-Ho Nam, Il Ju Choi, Young-Woo Kim
    Annals of Surgery.2010; 251(3): 428.     CrossRef
  • Assessment of DNA methylation for the detection of cervical neoplasia in liquid-based cytology specimens
    Jo-Heon Kim, Yoo Duk Choi, Ji Shin Lee, Jae Hyuk Lee, Jong Hee Nam, Chan Choi
    Gynecologic Oncology.2010; 116(1): 99.     CrossRef
  • A case–control study on seaweed consumption and the risk of breast cancer
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    British Journal of Nutrition.2010; 103(9): 1345.     CrossRef
  • Epidermal growth factor receptor intron 1 CA dinucleotide repeat polymorphism and survival of advanced gastric cancer patients treated with cetuximab plus modified FOLFOX6
    Sae‐Won Han, Do‐Youn Oh, Seock‐Ah Im, Sook Ryun Park, Keun‐Wook Lee, Hong Suk Song, Nam‐Su Lee, Kyung Hee Lee, In Sil Choi, Moon Hee Lee, Min A Kim, Woo Ho Kim, Yung‐Jue Bang, Tae‐You Kim
    Cancer Science.2010; 101(3): 793.     CrossRef
  • Quantitative assessment of DNA methylation for the detection of cervical neoplasia in liquid-based cytology specimens
    Jo-Heon Kim, Yoo Duk Choi, Ji Shin Lee, Jae Hyuk Lee, Jong Hee Nam, Chan Choi, Sun-Seog Kweon, Mary Jo Fackler, Saraswati Sukumar
    Virchows Archiv.2010; 457(1): 35.     CrossRef
  • Role of body mass index as a risk and prognostic factor of endometrioid uterine cancer in Korean women
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    Gynecologic Oncology.2010; 118(1): 24.     CrossRef
  • Metastatic lymph node in gastric cancer; Is it a real distant metastasis?
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    BMC Cancer.2010;[Epub]     CrossRef
  • Upregulation of SPRR3 Promotes Colorectal Tumorigenesis
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  • Medications at the End of Life Care for Terminal Cancer Patients during Their Last Admission
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  • Functional polymorphism in manganese superoxide dismutase and antioxidant status: Their interactions on the risk of cervical intraepithelial neoplasia and cervical cancer
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  • A Validation of Estimating the National Cancer Incidence in Korea using the Databases of 7 Population-based Regional Cancer Registries except Seoul

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  • Prognostic Significance of Intraoperatively Estimated Surgical Stage in Curatively Resected Gastric Cancer Patients
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  • Developing an Institutional Protocol Guideline for Laparoscopy-Assisted Distal Gastrectomy
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    Annals of Surgical Oncology.2009; 16(8): 2231.     CrossRef
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  • No Association between Promoter Polymorphism of STK11 Gene and Lung Cancer Risk in the Korean Population
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    Cancer Research and Treatment.2009; 41(4): 211.     CrossRef
  • Annual Change of Clinicopathologic Characteristics after Radical Gastrectomy due to Gastric Cancer
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  • Cost‐Effectiveness of Eradication of Helicobacter pylori in Gastric Cancer Survivors After Endoscopic Resection of Early Gastric Cancer
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  • Technical feasibility and safety of laparoscopy‐assisted total gastrectomy in gastric cancer: A comparative study with laparoscopy‐assisted distal gastrectomy
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    World Journal of Gastroenterology.2009; 15(40): 5086.     CrossRef
  • Human Papillomavirus Infection and Cervical Cancer Prevention in Japan and Korea
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    Vaccine.2008; 26: M30.     CrossRef
  • Global Activity of Cancer Registries and Cancer Control and Cancer Incidence Statistics in Korea
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  • Diagnostic Accuracy of Cervicovaginal Cytology in the Detection of Squamous Epithelial Lesions of the Uterine Cervix; Cytologic/Histologic Correlation of 481 Cases
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    The Korean Journal of Cytopathology.2008; 19(2): 111.     CrossRef
  • Association of Single Nucleotide Polymorphisms in PIM-1 Gene with the Risk of Korean Lung Cancer
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    Cancer Research and Treatment.2008; 40(4): 190.     CrossRef
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