Cancer Research and Treatment

Original Article

Pediatric cancer

Long-term Outcomes of Protocol-Based Treatment for Newly Diagnosed Medulloblastoma: Won Kee Ahn, Seung Min Hahn, Hong In Yoon, Jeongshim Lee, Eun Kyung Park, Kyu Won Shim, Dong Seok Kim, Chang-Ok Suh, Se Hoon Kim, Chuhl Joo Lyu, Jung Woo Han; Cancer Res Treat. 2024;56(2):652-664. Published online November 30, 2023; DOI: https://doi.org/10.4143/crt.2023.865

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Purpose
The Korean Society of Pediatric Neuro-Oncology (KSPNO) conducted treatment strategies for children with medulloblastoma (MB) by using alkylating agents for maintenance chemotherapy or tandem high-dose chemotherapy (HDC) with autologous stem cell rescue (ASCR) according to the risk stratification. The purpose of the study was to assess treatment outcomes and complications based on risk-adapted treatment and HDC.
Materials and Methods
Fifty-nine patients diagnosed with MB were enrolled in this study. Patients in the standard-risk (SR) group received radiotherapy (RT) after surgery and chemotherapy using the KSPNO M051 regimen. Patients in the high-risk (HR) group received two and four chemotherapy cycles according to the KSPNO S081 protocol before and after reduced RT for age following surgery and two cycles of tandem HDC with ASCR consolidation treatment.
Results
In the SR group, 24 patients showed 5-year event-free survival (EFS) and overall survival (OS) estimates of 86.7% (95% confidence interval [CI], 73.6 to 100) and 95.8% (95% CI, 88.2 to 100), respectively. In the HR group, more infectious complications and mortality occurred during the second HDC than during the first. In the HR group, the 5-year EFS and OS estimates were 65.5% (95% CI, 51.4 to 83.4) and 72.3% (95% CI, 58.4 to 89.6), respectively.
Conclusion
High intensity of alkylating agents for SR resulted in similar outcomes but with a high incidence of hematologic toxicity. Tandem HDC with ASCR for HR induced favorable EFS and OS estimates compared to those reported previously. However, infectious complications and treatment-related mortalities suggest that a reduced chemotherapy dose is necessary, especially for the second HDC.

Citations

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Ferroptosis Transcriptional Regulation and Prognostic Impact in Medulloblastoma Subtypes Revealed by RNA-Seq
Christophe Desterke, Yuanji Fu, Jenny Bonifacio-Mundaca, Claudia Monge, Pascal Pineau, Jorge Mata-Garrido, Raquel Francés
Antioxidants.2025; 14(1): 96. CrossRef

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Case Reports

Diagnostic Laparoscopy of Patient with Deep Vein Thrombosis before Diagnosis of Ovarian Cancer : A Case Report: Jae Eun Ha, Yong Seok Lee, Hae Nam Lee, Eun Kyung Park; Cancer Res Treat. 2010;42(1):48-52. Published online March 31, 2010; DOI: https://doi.org/10.4143/crt.2010.42.1.48

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Venous thromboembolism (VTE) is a common complication in patients with malignant disease. Epidemiological studies have demonstrated an increased risk of subsequent cancer in the patients who are diagnosed with idiopathic venous thrombosis. Cancers of the breast, lung and ovary in women and adenocarcinomas of an unknown primary cancer are most strongly associated with thrombosis. Mucin-producing cancers are most often associated with VTE and the highest rates of VTE were found for cases of ovarian cancer, but the absolute risk of cancer after thrombosis is relatively low (about 2% over the first year) and so the benefit of screening for cancer in thrombosis patients seems limited. But as this case, the association between thrombosis and occult cancer shows the importance of this association for patients who have thrombosis that is unresponsive to anticoagulant therapy. Especially, we should recognize that such patients can undergo investigation for an underlying malignancy. Diagnostic laparoscopy of an adnexal mass for confirming cancer in the acute setting of deep vein thrombosis (DVT) was performed for our patient. We report here on a case of a patient with DVT in the upper and lower extremities before the diagnosis of ovarian cancer, and we briefly review of the relevant literature.

Citations

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Analysis of the Preventive Action of Rivaroxaban against Lower Extremity Deep Venous Thrombosis in Patients after Laparoscopic Radical Gastrectomy
Qinhui Dong, Xiayin Zhu, Yafen Gao, Zhengrong Wang, Dexing Zheng, Jian Zhu, Pan Zheng
Computational and Mathematical Methods in Medicine.2022; 2022: 1. CrossRef
Increase in Carbohydrate Antigen 19-9 Levels without Tumor Progression after Polaprezinc Administration that Induced Deep Vein Thrombosis in a Colon Cancer Patient
Masahito Naito, Ryota Torii, Yuki Hashimoto, Yuki Kawamoto, Kenichi Hayashi, Hiroaki Shinoda, Yumiko Honjo, Motoki Hiroyoshi
Chemotherapy.2019; 64(3): 163. CrossRef
Optimal cytoreductive surgery for underlying ovarian cancer associated with deep venous thrombosis without placement of inferior vena cava filter: A case report and literature review
HONGWEI SHEN, JIANHONG SHANG, GANG NIU, JUN LIU, ZESHAN YOU, SHANYANG HE
Oncology Letters.2015; 10(4): 2579. CrossRef

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Primary Carcinoma of the Fallopian Tube: Report of Two Cases with Literature Review: In Cheul Jeung, Yong Seok Lee, Hae Nam Lee, Eun Kyung Park; Cancer Res Treat. 2009;41(2):113-116. Published online June 30, 2009; DOI: https://doi.org/10.4143/crt.2009.41.2.113

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Primary fallopian tube carcinoma (PFTC) is a rare tumor that histologically and clinically resembles epithelial ovarian cancer. PFTC has a worse prognosis than ovarian cancer as it is not routinely suspected and so treatment may be delayed. The early clinical manifestations and a prompt investigation can often lead to a correct diagnosis at an early stage. The preoperative diagnosis is usually difficult, and most patients with PFTC undergo laparotomy with the presumed diagnosis of ovarian carcinoma according to the presence of an adnexal mass. PFTC can present preoperatively as a tubo-ovarian abscess and it should be considered in the differential diagnosis of acute pelvic peritonitis. PFTC should be suspected by clinicians even if the presenting symptoms are atypical. We report here on two cases of PFTC along with a brief review of the literature.

Citations

Citations to this article as recorded by

Isolated splenic metastasis from primary fallopian tube carcinoma and the application of laparoscopic splenectomy: a case report and literature review
Dongxue Kang, Danyang Zhao, Xiaodi Jiang, Deming Li
Frontiers in Oncology.2023;[Epub] CrossRef
Primary Fallopian Tube Carcinoma: An Extremely Rare Gynecological Cancer Misdiagnosed Intraoperatively as Benign Ovarian Neoplasm: A Case Report
Efthymia Thanasa, Dimitra Stamouli, Ektoras-Evangelos Gerokostas, Konstantina Balafa, Nikoleta Koutalia, Ioannis Thanasas
Clinics and Practice.2022; 12(3): 253. CrossRef
HE4 is associated with clinical risk prognostic factors and survival outcome in primary fallopian tube carcinoma patients
Dong Mi, Yuexiang Zhang, Shuqin Chen
Journal of Obstetrics and Gynaecology Research.2022; 48(7): 1897. CrossRef
Primary Fallopian Tube Cancer in an 89-Year-Old Patient
Emmanuel N. Kontomanolis, Antonios Koutras, Thomas Ntounis, Michail Diakosavvas, Kyveli Angelou, Athina A. Samara, Themistoklis Grigoriadis, Pelagia Kadari, Ioannis Tsirkas, Marianna Theodora, Zacharias Fasoulakis, Cem Ficicioglu
Case Reports in Obstetrics and Gynecology.2021; 2021: 1. CrossRef
Problems of primary fallopian tube cancer diagnostics during and after surgery
D.G. Sumtsov, I.Z. Gladchuk, G.O. Sumtsov, N.I. Hyriavenko, M.S. Lyndin, V.V. Sikora, V.M. Zaporozhan
REPRODUCTIVE ENDOCRINOLOGY.2021; (59): 66. CrossRef
Tubal cancer in a young woman camouflaged as bilateral salpingitis
Victoria Psomiadou, Christos Iavazzo, Athanasios Douligeris, Anastasia Prodromidou, Elpis Galati, Natasa Novkovic, Loukas Karelis, Emmanouil Oikonomidis, Evgenia Karavioti, George Vorgias, Nikolaos Kalinoglou
Journal of Obstetrics and Gynaecology.2020; 40(8): 1178. CrossRef
Primary Fallopian Tube Carcinoma: A Case Report and Literature Review
Meral Rexhepi, Elizabeta Trajkovska, Hysni Ismaili, Florin Besimi, Nagip Rufati
Open Access Macedonian Journal of Medical Sciences.2017; 5(3): 344. CrossRef
BILATERAL FALLOPIAN TUBE ADENOCARCINOMA
Anuradha Calicut Kini Rao, Archana Shivamurthy, Vidya Monappa
Journal of Evolution of Medical and Dental Sciences.2015; 4(33): 5757. CrossRef
Primary Fallopian-Tube Carcinoma
Soumyesh Ghosh, Prashant Goyal, Shelly Sehgal, Pritish Shukla, Awanindra Kumar, Sompal Singh
Journal of Gynecologic Surgery.2014; 30(2): 111. CrossRef
Carcinoma de las trompas de Falopio
R. Albalat, J. Jiménez, F. Márquez, C. Lizarralde
Clínica e Investigación en Ginecología y Obstetricia.2012; 39(2): 86. CrossRef

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Original Article

Photogem Induces Necrosis in Various Uterine Cervical Cancer Cell Lines by PDT: Su Mi Bae, Seung Won Huh, Eun Kyung Park, Keun Ho Lee, Joon Mo Lee, Sung Eun Namkoong, Sei Jun Han, Chong Kook Kim, Jong Ki Kim, Yong Wan Kim, Woong Shick Ahn; Cancer Res Treat. 2003;35(6):549-556. Published online December 31, 2003; DOI: https://doi.org/10.4143/crt.2003.35.6.549

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PURPOSE
In order to elucidate the antitumor effect of photodynamic therapy (PDT), using a derivative of the photosensitizing agent hematoporphyrin (Photogem) and a diode laser, the cell death of uterine cancer cell lines (CaSki, HT3, HeLa, and SKOV-3), and mice transplanted with TC-1 lung cancer cells, were evaluated. MATERIALS AND METHODS: The morphological changes, MTT assay, flow cytometry, cytotoxicity and tumor growth inhibition study were evaluated at various time intervals after the PDT.
RESULTS
The results showed that the survival rates of each cell line decreased with time and dose response after performing the PDT. Also, the PDT-induced damage of cancer cells was almost entirely confined to necrosis of the tumor cells in the early time courses. The irradiation of CaSki cells in the presence of Photogem induced plasma membrane disruption and cell shrinkage, indicating the plasma membrane as the main target for Photogem. In the in vivo experiment, significantly longer survival and a significantly smaller tumor size were seen over the time courses of the Photogem with irradiation compared to the untreated control groups; resorption of the tumor was also observed after the PDT treatment. CONCLUSION: Collectively, our results indicated that Photogem possesses anti-tumor effects, and necrosis-like death, with plasma membrane damage, was postulated to be the principal mechanism of the antitumor effect of the PDT using Photogem.

Citations

Citations to this article as recorded by

Therapeutic effects of systemic photodynamic therapy in a leukemia animal model using A20 cells
Lan Ying Wen, Su-Mi Bae, Heung-Jae Chun, Kye-Shin Park, Woong Shick Ahn
Lasers in Medical Science.2012; 27(2): 445. CrossRef
Shift from Apoptotic to Necrotic Cell Death during Human Papillomavirus-induced Transformation of Keratinocytes
Nataly Kravchenko-Balasha, Sarit Mizrachy-Schwartz, Shoshana Klein, Alexander Levitzki
Journal of Biological Chemistry.2009; 284(17): 11717. CrossRef
Photodynamic Effects of Radachlorin® on Cervical Cancer Cells
Su-Mi Bae, Yong-Wook Kim, Joon-Mo Lee, Sung-Eun Namkoong, Sei-Jun Han, Jong-Ki Kim, Chang-Hee Lee, Heung-Jae Chun, Hyun-Sun Jin, Woong-Shick Ahn
Cancer Research and Treatment.2004; 36(6): 389. CrossRef

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