Cancer Research and Treatment

Original Articles

Proximal Resection Margins: More Prognostic than Distal Resection Margins in Patients Undergoing Hilar Cholangiocarcinoma Resection: Tae Yoo, Sang-Jae Park, Sung-Sik Han, Seong Hoon Kim, Seung Duk Lee, Tae Hyun Kim, Soon-ae Lee, Sang Myung Woo, Woo Jin Lee, Eun Kyung Hong; Cancer Res Treat. 2018;50(4):1106-1113. Published online November 16, 2017; DOI: https://doi.org/10.4143/crt.2017.320

Purpose
Even though the therapeutic gold standard of hilar cholangiocarcinoma (HCCA) resection is cancer-free resection margin (RM), surgical treatment still remains challenging. This study evaluated the prognostic significance of RM status in resected HCCA patients and identified survival prognostic factors.
Materials and Methods
We reviewed records of 96 HCCA patients who underwent surgery from 2001 to 2012 and analyzed the RM status and prognostic factors that affecting survival.
Results
Negative RM (n=31, 33%) was significantly associated with better survival vs. positive RM (n=65, 67%) (mean survival time [MST], 33 months vs. 21 months; p=0.011). Margins with histological findings of non-dysplastic epithelium, low-grade dysplasia, and carcinoma in situ were not associated with survival differences (MST, 33 months vs. 33 months vs. 30 months; p=0.452), whereas positive margins were associated with poorer survival relative to carcinoma in situ (MST, 30 months vs. 21 months; p=0.050). Among patients with R0 resection, narrow (≤ 5 mm) and wide (> 5 mm) margins were not associated with survival differences (MST, 33 months vs. 30 months; p=0.234). Although positive proximal RM was associated with poorer survival compared to negative RM (MST, 19 vs. 33; p=0.002), no survival difference was observed between positive and negative distal RMs (MST, 30 vs. 33; p=0.628). Proximal RM positivity (hazard ratio [HR], 2.688; p=0.007) and nodal involvement (HR, 3.293; p < 0.001) were independent survival prognostic factors.
Conclusion
A clear RM, especially proximal RM status, was significant prognosticator, and proximal bile duct resection to the greatest technically feasible extent may be necessary, with careful consideration of the potential morbidity and oncologic outcomes after resection. However, an aggressive approach to obtain a negative distal RM might be controversial and should be considered carefully, depending on the patient's status.

Citations

Citations to this article as recorded by

Current advance in comprehensive management of hilar cholangiocarcinoma and navigation in surgery: non-systematic reviews
Man Luo, Jiapeng Yang, Kai Zhang, Ji Sun, Zhiyu Lu, Zhihao Wang, Yaowei Hu, Jianxin Zhai, Peng Xie, Tana Siqin, Mengran Lang, Xuan Meng, Hongguang Wang
International Journal of Surgery.2025; 111(2): 2131. CrossRef
Molecular profiling and prognostic analysis in Chinese cholangiocarcinoma: an observational, retrospective single-center study
Changkun Zhang, Xia You, Qin Zhang, Dong Wang
Investigational New Drugs.2024; 42(1): 24. CrossRef
Radiographic features predictive of recurrence and survival after surgical resection of perihilar cholangiocarcinoma
Julaluck Promsorn, Panjaporn Naknan, Aumkhae Sookprasert, Kosin Wirasorn, Jarin Chindaprasirt, Attapol Titapun, Piyapharom Intarawichian, Mukesh Harisinghani
Heliyon.2024; 10(7): e28805. CrossRef
Practice guidelines for managing extrahepatic biliary tract cancers
Hyung Sun Kim, Mee Joo Kang, Jingu Kang, Kyubo Kim, Bohyun Kim, Seong-Hun Kim, Soo Jin Kim, Yong-Il Kim, Joo Young Kim, Jin Sil Kim, Haeryoung Kim, Hyo Jung Kim, Ji Hae Nahm, Won Suk Park, Eunkyu Park, Joo Kyung Park, Jin Myung Park, Byeong Jun Song, Yong
Annals of Hepato-Biliary-Pancreatic Surgery.2024; 28(2): 161. CrossRef
Influence of Perineural (Pn), Lymphangio (L) and Vascular (V) Invasion on Survival after Resection of Perihilar Cholangiocarcinoma
Rabea Margies, Lisa-Katharina Gröger, Beate K. Straub, Fabian Bartsch, Hauke Lang
Cancers.2024; 16(20): 3463. CrossRef
Liver transplantation for unresectable Klatskin tumor: experience of two centers, first distant results
D. A. Granov, V. N. Zhuikov, I. I. Tileubergenov, A. V. Moiseenko, I. O. Rutkin, A. R. Sheraliev, A. A. Polikarpov, O. O. Rummo, A. E. Shcherba, I. P. Shturich, S. V. Korotkov, L. V. Kirkovsky, T. M. Chernishov
Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery.2024; 29(3): 70. CrossRef
Significance of dysplasia in bile duct resection margin in patients with extrahepatic cholangiocarcinoma: A retrospective analysis
Jung Wan Choe, Hyo Jung Kim, Jae Seon Kim
World Journal of Clinical Cases.2022; 10(10): 3078. CrossRef
Klatskin Tumor: A Survival Analysis According to Tumor Characteristics and Inflammatory Ratios
Vlad-Ionuţ Nechita, Emil Moiş, Luminiţa Furcea, Mihaela-Ancuţa Nechita, Florin Graur
Medicina.2022; 58(12): 1788. CrossRef
Impact of Remnant Carcinoma in Situ at the Ductal Stump on Long‐Term Outcomes in Patients with Distal Cholangiocarcinoma
Koya Yasukawa, Akira Shimizu, Hiroaki Motoyama, Koji Kubota, Tsuyoshi Notake, Kentaro Fukushima, Tomohiko Ikehara, Hikaru Hayashi, Akira Kobayashi, Yuji Soejima
World Journal of Surgery.2021; 45(1): 291. CrossRef
Comprehensive analysis of genomic alterations of Chinese hilar cholangiocarcinoma patients
Feiling Feng, Xiaobing Wu, Xiaoliang Shi, Qingxiang Gao, Yue Wu, Yong Yu, Qingbao Cheng, Bin Li, Bin Yi, Chen Liu, Qing Hao, Lin Zhang, Chunfang Gao, Xiaoqing Jiang
International Journal of Clinical Oncology.2021; 26(4): 717. CrossRef
Prognostic Impact of Perioperative CA19-9 Levels in Patients with Resected Perihilar Cholangiocarcinoma
Jong Woo Lee, Jae Hoon Lee, Yejong Park, Jaewoo Kwon, Woohyung Lee, Ki Byung Song, Dae Wook Hwang, Song Cheol Kim
Journal of Clinical Medicine.2021; 10(7): 1345. CrossRef
Prognostic Predictability of American Joint Committee on Cancer 8th Staging System for Perihilar Cholangiocarcinoma: Limited Improvement Compared with the 7th Staging System
Jong Woo Lee, Jae Hoon Lee, Yejong Park, Woohyung Lee, Jaewoo Kwon, Ki Byung Song, Dae Wook Hwang, Song Cheol Kim
Cancer Research and Treatment.2020; 52(3): 886. CrossRef
Comparative study of laparoscopic‐assisted and open total gastrectomy for Siewert Types II and III adenocarcinoma of the esophagogastric junction
Jianchu Wang, Jin‐Cheng Wang, Bin Song, Xu‐Dong Dai, Xiao‐Yu Zhang
Journal of Cellular Physiology.2019; 234(7): 11235. CrossRef
Surgical management of carcinoma in situ at ductal resection margins in patients with extrahepatic cholangiocarcinoma
Toshifumi Wakai, Jun Sakata, Tomohiro Katada, Yuki Hirose, Daiki Soma, Pankaj Prasoon, Kohei Miura, Takashi Kobayashi
Annals of Gastroenterological Surgery.2018; 2(5): 359. CrossRef

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Induction Chemotherapy with Gemcitabine and Cisplatin Followed by Simultaneous Integrated Boost–Intensity Modulated Radiotherapy with Concurrent Gemcitabine for Locally Advanced Unresectable Pancreatic Cancer: Results from a Feasibility Study: Sang Myung Woo, Min Kyeong Kim, Jungnam Joo, Kyong-Ah Yoon, Boram Park, Sang-Jae Park, Sung-Sik Han, Ju Hee Lee, Eun Kyung Hong, Yun-Hee Kim, Hae Moon, Sun-Young Kong, Tae Hyun Kim, Woo Jin Lee; Cancer Res Treat. 2017;49(4):1022-1032. Published online January 19, 2017; DOI: https://doi.org/10.4143/crt.2016.495

Abstract PDF Supplementary Material PubReader ePub

Purpose
This study assessed the feasibility and compliance of induction chemotherapy with gemcitabine and cisplatin followed by simultaneous integrated boost–intensity modulated radiotherapy (SIB-IMRT) with concurrent gemcitabine in patients with locally advanced unresectable pancreatic cancer.
Materials and Methods
In this trial, patients received induction chemotherapy consisting of gemcitabine (1,000 mg/m²) and cisplatin (25 mg/m2) on days 1, 8, and 15 of each treatment cycle. Patients were subsequently treated with gemcitabine (300 mg/m²/wk) during SIB-IMRT. The patients received total doses of 55 and 44 Gy in 22 fractions to planning target volume 1 and 2, respectively. As an ancillary study, digital polymerase chain reaction was performed to screen for the seven most common mutations in codons 12 and 13 of the KRAS oncogene of circulating cell free DNA (cfDNA).
Results
Forty-four patients were enrolled between 2012 and 2015. Of these, 33 (75%) completed the treatment. The most common toxicities during induction chemotherapy were grades 3 and 4 neutropenia (18.2%), grade 3 nausea (6.8%) and vomiting (6.8%). The most common toxicities during SIB-IMRT were grade 3 neutropenia (24.2%) and grade 3 anemia (12.1%). Ten patients (23%) underwent a curative resection after therapy. Median overall survival was significantly longer in patients who underwent curative resection (16.8 months vs. 11 months, p < 0.01). The median cfDNA concentration was significantly lower after treatment (108.5 ng/mL vs. 18.4 ng/mL, p < 0.001).
Conclusion
Induction chemotherapy with gemcitabine and cisplatin followed by concurrent SIB-IMRT was well tolerated and active.

Citations

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Executive Summary of the American Radium Society Appropriate Use Criteria for Neoadjuvant Therapy for Nonmetastatic Pancreatic Adenocarcinoma
Krishan R. Jethwa, Ed Kim, Jordan Berlin, Christopher J. Anker, Leila Tchelebi, Gerard Abood, Christopher L. Hallemeier, Salma Jabbour, Timothy Kennedy, Rachit Kumar, Percy Lee, Navesh Sharma, William Small, Vonetta Williams, Suzanne Russo
American Journal of Clinical Oncology.2024; 47(4): 185. CrossRef
Kinetics of plasma cell-free DNA as a prospective biomarker to predict the prognosis and radiotherapy effect of esophageal cancer
Y. Li, J. Wu, Y. Feng, D. Wang, H. Tao, J. Wen, F. Jiang, P. Qian, Y. Liu
Cancer/Radiothérapie.2024; 28(3): 242. CrossRef
Circulating tumor DNA: a help to guide therapeutic strategy in patients with borderline and locally advanced pancreatic adenocarcinoma?
Olivier Caliez, Daniel Pietrasz, Feryel Ksontini, Solène Doat, Jean-Marc Simon, Jean-Christophe Vaillant, Valerie Taly, Pierre Laurent-Puig, Jean-Baptiste Bachet
Digestive and Liver Disease.2022; 54(10): 1428. CrossRef
Circulating Tumor DNA Detection by Digital-Droplet PCR in Pancreatic Ductal Adenocarcinoma: A Systematic Review
Marisol Huerta, Susana Roselló, Luis Sabater, Ana Ferrer, Noelia Tarazona, Desamparados Roda, Valentina Gambardella, Clara Alfaro-Cervelló, Marina Garcés-Albir, Andrés Cervantes, Maider Ibarrola-Villava
Cancers.2021; 13(5): 994. CrossRef
Clinical Utility of Liquid Biopsy-Based Actionable Mutations Detected via ddPCR
Irina Palacín-Aliana, Noemí García-Romero, Adrià Asensi-Puig, Josefa Carrión-Navarro, Víctor González-Rumayor, Ángel Ayuso-Sacido
Biomedicines.2021; 9(8): 906. CrossRef
A review on the efficacy and safety of iodine-125 seed implantation in unresectable pancreatic cancers
Sheng-Nan Jia, Fu-Xing Wen, Ting-Ting Gong, Xin Li, Hui-Jie Wang, Ya-Min Sun, Ze-Cheng Yang
International Journal of Radiation Biology.2020; 96(3): 383. CrossRef
Efficacy and feasibility of proton beam radiotherapy using the simultaneous integrated boost technique for locally advanced pancreatic cancer
Tae Hyun Kim, Woo Jin Lee, Sang Myung Woo, Eun Sang Oh, Sang Hee Youn, Hye Young Jang, Sung-Sik Han, Sang-Jae Park, Yang-Gun Suh, Sung Ho Moon, Sang Soo Kim, Dae Yong Kim
Scientific Reports.2020;[Epub] CrossRef
Comprehensive Cancer Panel Sequencing Defines Genetic Diversity and Changes in the Mutational Characteristics of Pancreatic Cancer Patients Receiving Neoadjuvant Treatment
Kyong-Ah Yoon, Sang Myung Woo, Yun-Hee Kim, Sun-Young Kong, Min Kyoung Lee, Sung-Sik Han, Tae Hyun Kim, Woo Jin Lee, Sang-Jae Park
Gut and Liver.2019; 13(6): 683. CrossRef
Plasma Cell-Free DNA as a Predictive Marker after Radiotherapy for Hepatocellular Carcinoma
Sangjoon Park, Eun Jung Lee, Chai Hong Rim, Jinsil Seong
Yonsei Medical Journal.2018; 59(4): 470. CrossRef
Effectiveness and Safety of Simultaneous Integrated Boost-Proton Beam Therapy for Localized Pancreatic Cancer
Tae Hyun Kim, Woo Jin Lee, Sang Myung Woo, Hyunjung Kim, Eun Sang Oh, Ju Hee Lee, Sung-Sik Han, Sang-Jae Park, Yang-Gun Suh, Sung Ho Moon, Sang Soo Kim, Dae Yong Kim
Technology in Cancer Research & Treatment.2018;[Epub] CrossRef

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A New Cell Block Method for Multiple Immunohistochemical Analysis of Circulating Tumor Cells in Patients with Liver Cancer: Soo Jeong Nam, Hyun Yang Yeo, Hee Jin Chang, Bo Hyun Kim, Eun Kyung Hong, Joong-Won Park; Cancer Res Treat. 2016;48(4):1229-1242. Published online March 30, 2016; DOI: https://doi.org/10.4143/crt.2015.500

Abstract PDF PubReader ePub

Purpose
We developed a new method of detecting circulating tumor cells (CTCs) in liver cancer patients by constructing cell blocks from peripheral blood cells, including CTCs, followed by multiple immunohistochemical analysis.
Materials and Methods
Cell blockswere constructed from the nucleated cell pellets of peripheral blood afterremoval of red blood cells. The blood cell blocks were obtained from 29 patients with liver cancer, and from healthy donor blood spikedwith seven cell lines. The cell blocks and corresponding tumor tissues were immunostained with antibodies to seven markers: cytokeratin (CK), epithelial cell adhesion molecule (EpCAM), epithelial membrane antigen (EMA), CK18, α-fetoprotein (AFP), Glypican 3, and HepPar1.
Results
The average recovery rate of spiked SW620 cells from blood cell blocks was 91%. CTCs were detected in 14 out of 29 patients (48.3%); 11/23 hepatocellular carcinomas (HCC), 1/2 cholangiocarcinomas (CC), 1/1 combined HCC-CC, and 1/3 metastatic cancers. CTCs from 14 patients were positive for EpCAM (57.1%), EMA (42.9%), AFP (21.4%), CK18 (14.3%), Gypican3 and CK (7.1%, each), and HepPar1 (0%). Patients with HCC expressed EpCAM, EMA, CK18, and AFP in tissue and/or CTCs, whereas CK, HepPar1, and Glypican3 were expressed only in tissue. Only EMA was significantly associated with the expressions in CTC and tissue. CTC detection was associated with higher T stage and portal vein invasion in HCC patients.
Conclusion
This cell block method allows cytologic detection and multiple immunohistochemical analysis of CTCs. Our results show that tissue biomarkers of HCC may not be useful for the detection of CTC. EpCAM could be a candidate marker for CTCs in patients with HCC.

Citations

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Hydrogel-based technologies in liquid biopsy for the detection of circulating clinical markers: challenges and prospects
Young Jun Kim, Junhong Min
Analytical and Bioanalytical Chemistry.2024; 416(9): 2065. CrossRef
Diagnostic value of expressions of cancer stem cell markers for adverse outcomes of hepatocellular carcinoma and their associations with prognosis: A Bayesian network meta‑analysis
Zhengrong Ou, Shoushuo Fu, Jian Yi, Jingxuan Huang, Weidong Zhu
Oncology Letters.2024;[Epub] CrossRef
Finding the seed of recurrence: Hepatocellular carcinoma circulating tumor cells and their potential to drive the surgical treatment
Francesca Carissimi, Matteo Nazzareno Barbaglia, Livia Salmi, Cristina Ciulli, Linda Roccamatisi, Giuseppe Cordaro, Venkata Ramana Mallela, Rosalba Minisini, Biagio Eugenio Leone, Matteo Donadon, Guido Torzilli, Mario Pirisi, Fabrizio Romano, Simone Famul
World Journal of Gastrointestinal Surgery.2021; 13(9): 967. CrossRef
Fabrication of Formalin-Fixed, Paraffin-Embedded (FFPE) Circulating Tumor Cell (CTC) Block Using a Hydrogel Core-Mediated Method
Tae Hee Lee, Young Jun Kim, Woo Sun Rou, Hyuk Soo Eun
Micromachines.2021; 12(9): 1128. CrossRef
Isolation and morphology of circulating tumor cells by cell block technique in breast cancer
Nandini Agrawal, Rajpal S. Punia, Uma Handa, Ashok K. Attri
Indian Journal of Pathology and Microbiology.2021; 64(2): 329. CrossRef
Circulating tumor cells in the clinical cancer diagnosis
P. Zhang, H. Zhou, K. Lu, Y. Wang, T. Feng
Clinical and Translational Oncology.2020; 22(3): 279. CrossRef
A microfluidic system based on the monoclonal antibody BCMab1 specifically captures circulating tumor cells from bladder cancer patients
Yunchao Wang, Qing Liu, Tongyi Men, Ye Liang, Haitao Niu, Jianning Wang
Journal of Biomaterials Science, Polymer Edition.2020; 31(9): 1199. CrossRef
The Significance of Circulating Tumor Cells in Patients with Hepatocellular Carcinoma: Real-Time Monitoring and Moving Targets for Cancer Therapy
Feiyu Chen, Zhangfeng Zhong, Hor-Yue Tan, Ning Wang, Yibin Feng
Cancers.2020; 12(7): 1734. CrossRef
The Role of Proteoglycans in Cancer Metastasis and Circulating Tumor Cell Analysis
Theresa D. Ahrens, Sara R. Bang-Christensen, Amalie M. Jørgensen, Caroline Løppke, Charlotte B. Spliid, Nicolai T. Sand, Thomas M. Clausen, Ali Salanti, Mette Ø. Agerbæk
Frontiers in Cell and Developmental Biology.2020;[Epub] CrossRef
Efficient Detection and Single-Cell Extraction of Circulating Tumor Cells in Peripheral Blood
Rui Li, Zhiyi Gong, Kezhen Yi, Wei Li, Yichao Liu, Fubing Wang, Shi-shang Guo
ACS Applied Bio Materials.2020; 3(9): 6521. CrossRef
Downregulation of cytokeratin 18 induces cellular partial EMT and stemness through increasing EpCAM expression in breast cancer
Ruizan Shi, Linhong Liu, Fengge Wang, Yifan He, Yanan Niu, Chang Wang, Xuanping Zhang, Xiuli Zhang, Huifeng Zhang, Min Chen, Yan Wang
Cellular Signalling.2020; 76: 109810. CrossRef
Cell blocks in cytopathology: An update
Aruna Nambirajan, Deepali Jain
Cytopathology.2018; 29(6): 505. CrossRef
Cytopathological Study of the Circulating Tumor Cells filtered from the Cancer Patients’ Blood using Hydrogel-based Cell Block Formation
Yoon-Tae Kang, Young Jun Kim, Tae Hee Lee, Young-Ho Cho, Hee Jin Chang, Hyun-Moo Lee
Scientific Reports.2018;[Epub] CrossRef
Dual-patterned immunofiltration (DIF) device for the rapid efficient negative selection of heterogeneous circulating tumor cells
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Bcl-2 as a Predictive Factor for Biochemical Recurrence after Radical Prostatectomy: An Interim Analysis: In-Chang Cho, Han Soo Chung, Kang Su Cho, Jeong Eun Kim, Jae Young Joung, Ho Kyung Seo, Jinsoo Chung, Weon Seo Park, Eun Kyung Hong, Kang Hyun Lee; Cancer Res Treat. 2010;42(3):157-162. Published online September 30, 2010; DOI: https://doi.org/10.4143/crt.2010.42.3.157

Abstract PDF PubReader ePub

Purpose

The objective of this study was to determine Bcl-2 expression in localized prostate cancer and its potential role as a predictive factor for biochemical recurrence (BCR).

Materials and Methods

This study included 171 Korean patients with newly diagnosed adenocarcinoma of the prostate who underwent radical prostatectomy (RP) without neoadjuvant therapy at a single center between February 2005 and May 2009. RP specimens obtained from these patients were analyzed for the expression of Bcl-2 using tissue microarray. The values of Bcl-2 and other clinicopathologic factors were evaluated. Statistical analysis was performed with contingency table analysis, chi-square tests, and a Cox proportional hazard model.

Results

Bcl-2 expression was immunohistologically-confirmed in 42 patients (24.6%). Bcl-2 expression was not associated with conventional clinicopathologic factors. Bcl-2 negative patients had a significantly longer mean BCR-free survival than Bcl-2-positive patients (p=0.036). Among several variables, a high Gleason score in the RP specimen (≥8), extraprostatic extension, seminal vesicle invasion (SVI), lymphovascular invasion (LVI), and Bcl-2 expression were significant predictors of BCR based on univariate analysis. Multivariate Cox proportional hazards analysis revealed that BCR was significantly associated with a high prostate specific antigen level (p=0.047), SVI (p<0.001), a positive surgical margin (p=0.004) and Bcl-2 expression (p=0.012).

Conclusion

Bcl-2 expression in RP specimens is associated with a significantly worse outcome, suggesting a potential clinical role for Bcl-2. Post-operative Bcl-2 could be a significant predictor of outcome after RP.

Citations

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Association of Lymphovascular Invasion with Biochemical Recurrence and Adverse Pathological Characteristics of Prostate Cancer: A Systematic Review and Meta-analysis
Jakub Karwacki, Marcel Stodolak, Andrzej Dłubak, Łukasz Nowak, Adam Gurwin, Kamil Kowalczyk, Paweł Kiełb, Nazar Holdun, Wojciech Szlasa, Wojciech Krajewski, Agnieszka Hałoń, Anna Karwacka, Tomasz Szydełko, Bartosz Małkiewicz
European Urology Open Science.2024; 69: 112. CrossRef
Immunohistochemical Expression of MDM2, Bcl-2, SATB2 and Ki-67 in Histological Variants of Unicystic Ameloblastoma
Koustubh Amol Surana, Deepak Pandiar, Reshma Poothakulath Krishnan
Head and Neck Pathology.2024;[Epub] CrossRef
Targeting the Intrinsic Apoptosis Pathway: A Window of Opportunity for Prostate Cancer
Daniel Westaby, Juan M. Jimenez-Vacas, Ana Padilha, Andreas Varkaris, Steven P. Balk, Johann S. de Bono, Adam Sharp
Cancers.2021; 14(1): 51. CrossRef
miR-205: A Potential Biomedicine for Cancer Therapy
Neeraj Chauhan, Anupam Dhasmana, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
Cells.2020; 9(9): 1957. CrossRef
Bcl‐2 is a prognostic marker and its silencing inhibits recurrence in ameloblastomas
Jue Young Kim, Jinsun Kim, Shadavlonjid Bazarsad, In‐Ho Cha, Sung‐Won Cho, Jin Kim
Oral Diseases.2019; 25(4): 1158. CrossRef
Tumor-Specific Induction of the Intrinsic Apoptotic Pathway—A New Therapeutic Option for Advanced Prostate Cancer?
Philipp Wolf
Frontiers in Oncology.2019;[Epub] CrossRef
PI3K pathway and Bcl-2 family. Clinicopathological features in prostate cancer
Norelia Torrealba, Gonzalo Rodriguez-Berriguete, Benito Fraile, Gabriel Olmedilla, Pilar Martínez-Onsurbe, Manuel Sánchez-Chapado, Ricardo Paniagua, Mar Royuela
The Aging Male.2018; 21(3): 211. CrossRef
Positive surgical margin is associated with biochemical recurrence risk following radical prostatectomy: a meta-analysis from high-quality retrospective cohort studies
Lijin Zhang, Bin Wu, Zhenlei Zha, Hu Zhao, Yuefang Jiang, Jun Yuan
World Journal of Surgical Oncology.2018;[Epub] CrossRef
The impact of lymphovascular invasion in patients with prostate cancer following radical prostatectomy and its association with their clinicopathological features
Wei Jiang, Lijin Zhang, Bin Wu, Zhenlei Zha, Hu Zhao, Yuan Jun, Yuefang Jiang
Medicine.2018; 97(49): e13537. CrossRef
Bcl2 en cáncer avanzado de próstata y asociación con resistencia a la castración
R.F. Velázquez-Macías, F.E. De La Torre-Rendón, G. Ramos-Rodríguez, C.A. Calzada-Mendoza, R.M. Coral-Vázquez
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Application of a new technique, spiral tissue microarrays constructed using needle biopsy specimens, to prostate cancer research
AKIRA KOMIYA, TOMONORI KATO, TAKASHI HORI, JUNYA FUKUOKA, KENJI YASUDA, HIDEKI FUSE
International Journal of Oncology.2014; 44(1): 195. CrossRef
MicroRNA-205, a novel regulator of the anti-apoptotic protein Bcl2, is downregulated in prostate cancer
BERLINDA VERDOODT, MATTHIAS NEID, MARKUS VOGT, VIKTORIA KUHN, SVEN-THORSTEN LIFFERS, REIN-JÜRI PALISAAR, JOACHIM NOLDUS, ANDREA TANNAPFEL, ALIREZA MIRMOHAMMADSADEGH
International Journal of Oncology.2013; 43(1): 307. CrossRef

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Radiation-induced Necrosis Deteriorating Neurological Symptoms and Mimicking Progression of Brain Metastasis after Stereotactic-guided Radiotherapy: Young Zoon Kim, Dae Yong Kim, Heon Yoo, Hee Seok Yang, Sang Hoon Shin, Eun Kyung Hong, Kwan Ho Cho, Seung Hoon Lee; Cancer Res Treat. 2007;39(1):16-21. Published online March 31, 2007; DOI: https://doi.org/10.4143/crt.2007.39.1.16

Abstract PDF PubReader ePub

Purpose

Although radiation-induced necrosis (RIN) is not a tumor in itself, the lesion progressively enlarges with mass effects and diffuse peritumoral edema in a way that resembles neoplasm. To identify the RIN that mimics progression of brain metastasis, we performed surgical resections of symptomatic RIN lesions.

Meterials and Methods

From June 2003 to December 2005, 7 patients received stereotactic-guided radiotherapy (SRT) for metastatic brain tumor, and they later underwent craniotomy and tumor resection due to the progressive mass effects and the peritumoral edema that caused focal neurological deficit. On MR imaging, a ring-like enhanced single lesion with massive peritumoral edema could not be distinguished from progression of brain metastasis.

Results

Four patients had non-small cell lung cancer, 2 patients had colorectal cancer and 1 patient had renal cell carcinoma. The mean tumor volume was 8.7 ml (range: 3.0~20.7 ml). The prescribed dose of SRT was 30 Gy with 4 fractions for one patient, 18 Gy for two patients and 20 Gy for the other four patients. The four patients who received SRT with a dose of 20 Gy had RIN with or without microscopic residual tumor cells.

Conclusions

Early detection of recurrent disease after radiotherapy and identifying radiation-induced tissue damage are important for delivering adequate treatment. Therefore, specific diagnostic tools that can distinguish RIN from progression of metastatic brain tumor need to be developed.

Citations

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Nektarios Kostopoulos, Francesca Costabile, Elisavet Krimitza, Silvia Beghi, Denisa Goia, Renzo Perales-Linares, George Thyfronitis, Michael J. LaRiviere, Elise A. Chong, Stephen J. Schuster, Amit Maity, Constantinos Koumenis, John P. Plastaras, Andrea Fa
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Maximilian J. Schwendner, Nico Sollmann, Christian D. Diehl, Markus Oechsner, Bernhard Meyer, Sandro M. Krieg, Stephanie E. Combs
Frontiers in Oncology.2018;[Epub] CrossRef
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Alireza M. Mohammadi, Jason L. Schroeder, Lilyana Angelov, Samuel T. Chao, Erin S. Murphy, Jennifer S. Yu, Gennady Neyman, Xuefei Jia, John H. Suh, Gene H. Barnett, Michael A. Vogelbaum
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Nathan McDannold, Yongzhi Zhang, Natalia Vykhodtseva
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Hongqing Zhuang, Yi Zheng, Junjie Wang, Joe Y. Chang, Xiaoguang Wang, Zhiyong Yuan, Ping Wang
Oncotarget.2016; 7(7): 7773. CrossRef
Discriminating radiation necrosis from tumor progression in gliomas: a systematic review what is the best imaging modality?
Ashish H. Shah, Brian Snelling, Amade Bregy, Payal R. Patel, Danoushka Tememe, Rita Bhatia, Evelyn Sklar, Ricardo J. Komotar
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Aberrant Crypt Foci in the Background Mucosa of Colorectal Adenocarcinoma: Dong Hoon Kim, Eun Kyung Hong; Cancer Res Treat. 2001;33(3):216-224. Published online June 30, 2001; DOI: https://doi.org/10.4143/crt.2001.33.3.216

Abstract PDF

PURPOSE
This study was performed in order to determine the histologic features, incidence & frequency of the Aberrant Crypt Foci (ACFs) including mucosal abnormalities arising in the sporadic colonic cancer.
MATERIALS AND METHODS
We investigated the proximal and distal colonic mucosa surrounding the tumor in 22 cases (right colon 7 cases and left colon 15 cases) of resected colonic adenocarcinoma specimen. The methylene blue- stained colonic mucosa was examined in en face preparations and rolled totally. The rolled colonic mucosa was embedded in paraffin and examined by using 4micrometer thick serial sections.
RESULTS
We found one hundred twenty two ACFs. The 97 foci (78.7%) were simple hypertrophic foci (SH), composed of more elongated and larger crypts than normal with apical branching associated with goblet cell hyperplasia. The 17 foci (13.9%) were hyperplastic foci (HP) resembling hyperplastic polyp, and 7 (5.7%) were adeno matous foci (AD) while 2 (1.6%) were adenomatous foci with dysplasia (Dys). The mean number of ACFs/cm of the examined mucosa were 0.18+/-0.21 and were higher in the left colon than in the right colon (0.22+/-0.24 vs. 0.10+/-0.10). Immunohistochemical stains for p53 and Ki-67 in these foci revealed strong and upper cryptal staining patterns in AD and Dys of ACFs, like that of neoplasia or preneoplastic condition. However, the staining intensities in SH and HP of ACFs were equal to or lower than that of normal crypts.
CONCLUSION
These results suggest that grossly defined ACFs include reactive process and the majority of ACFs are induced by simple reactive alteration without preneoplastic potential; and two types of ACFs (AD and Dys) are more likely to be direct precursors of colon tumors than SH or HP.

Citations

Citations to this article as recorded by

Hemoglobin induces colon cancer cell proliferation by release of reactive oxygen species
Ryung-Ah Lee
World Journal of Gastroenterology.2006; 12(35): 5644. CrossRef

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A Case of Ovarian Mullerian Mucinous Papillary Cystadenoma of Borderline Malignancy: Jae Gyu Lee, Sam Hyun Cho, Seung Ryong Kim, Jung Bae Yoo, Kyung Tai Kim, Hyung Moon, Youn Yeoung Hwang, Seung Sam Paik, Eun Kyung Hong; J Korean Cancer Assoc. 1997;29(3):522-527.

Abstract PDF: Ovarian mucinous cystadenoma of borderline malignancy was consisted of intestinal mucinous cystadenomas of borderline malignancy and Mullerian mucinous papillary borderline tumors. Mullerian mucinous papillary tumors was lined by mucinous epithelium of endocervical type and characterized by papillae architecturally similar to those of serous borderline tumors. These tumors have clinical and pathologic differences from those of intestinal mucinous cystadenomas of borderline malignancy.We report a case of ovarian Mullerian mucinous papillary cystadenomas of borderline malignancy with review of literature.

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Clinical Trial

Anti-tumor Effect of the Complex of Acriflavine and Guanosine (AG60): Eun Kyung Hong, Hwan Mook Kim, Kyung Yung Lee, Young Shin Chung, Bo Im Yoo, Sang Geon Kim, E Tay Ahn, Young Bok Han; J Korean Cancer Assoc. 1997;29(1):29-37.

Abstract PDF: PURPOSE
The anti-tumor effect of the complex of acriflavine and guanosine (AG60) was investigated.
MATERIALS AND METHODS
In vitro cytotoxicity of AG60 was measured using SRB assay, and in vivo antitumor activity of AG60 was examined in CDF1 mice intraperitoneally inoculated with the P388 leukemic cells and in ICR mice inguinally implanted with S-180 cells. Tumor size and mean survival time were determined.
RESULTS
AG60 and acriflavine showed strong anti-tumor effect in vitro on lung cancer (A549), renal cancer (UO-31) and colon cancer (COLO205) cells. However, AG60 did not show the cytotoxicity against normal cell line, 3T3. The range of the IC50 of AG60 to the various tumor cell lines was 0.09 microgram/ml through 1.94 microgram/ml. The treatment of ascitic tumor bearing CDF1 mice with AG60 resulted in over 160% increases in the mean survival time. The most effective dose of AG60 was 30 mg/kg body weight in tumor implanted mice. In solid tumor bearing ICR mice tumor growth and progression were suppressed in response to the different doses at 30 days; 69.8% suppression of tumor size in response to acriflavine, 16.0% to guanosine, 87.7% to AG60 and 78.5% to doxorubicin. In addition, 35% increases were observed in the means survival time of AG60 treated group compared with control group.
CONCLUSION
The prominant anti-tumor effects of AG60 shown in this report would represent the possibility of the clinical trials.

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Original Articles

Chemiluminescence assay for the monitoring of phagocytic activity of HL-60 cells stimulated by retinoic acid: Eun Kyung Hong, Young Ho Cho, Kyung Won Seo, Chang Kyoo Kim, Jung Jo Moon, Kyung Young Lee, Jong Bae Kim; J Korean Cancer Assoc. 1993;25(3):423-428.

Abstract PDF: No abstract available.

2,301 View
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Clinico-pathologic characteristics of gastric adenocarcinoma with increased serum alpha-fetoprotein: Tejune Chung, Kun Hyung Sung, Joung Soon Jang, Jong Chul Lee, Eun Kyung Hong, Jung Dal Lee; J Korean Cancer Assoc. 1992;24(5):674-683.

Abstract PDF: No abstract available.

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Histopathologic Study on Skeletal Chondrosarcomas: Hyung Doo Kim, Jong Jin Kim, Youn Wha Kim, Eun Kyung Hong, Seung Hae Ahn, Yong Koo Park, Young Hi Park, Ju Hie Lee, Nam Hee Won, Jin Tae Suh, Hyun Sook Chi, Moon Ho Yang, Jung Dal Lee; J Korean Cancer Assoc. 1983;15(1):14-23.

Abstract PDF: Twelve consecutive cases of chondrosarcoma and its histologic variants are analyzed histo- pathologically and include seven cases of ordinary(classic) type, two cases of mesenchymal type, one case of clear cell type and two cases of peripheral secondary type arising from one of multiple osteochondromas. One of seven classic chondrosarcomas is classified as dedifferen- tiated chondrosarcoma, which recurred locally five vears after initial surgical removal. Histologic features of the variants are described in details, and differential points on histo- logic findings and clinical manifestation as well are discussed.

2,645 View
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