Cancer Research and Treatment

Original Articles

Gastrointestinal cancer

Predictive Value of the nProfiler 1 Assay for the Efficacy of Adjuvant S-1–Based Doublet Chemotherapy in Stage III Gastric Cancer: A Post-Hoc Analysis of a Randomized Phase III Trial: Dong Ki Lee, Choong-kun Lee, Hyo Song Kim, Sun Jin Sym, Dae Young Zang, Ki Hyang Kim, Joo Han Lim, Hae Su Kim, Kyung Hee Lee, Heon Yung Gee, Sun Young Rha, Hyunki Kim, Minkyu Jung; Cancer Res Treat. 2025;57(3):770-780. Published online November 12, 2024; DOI: https://doi.org/10.4143/crt.2024.705

Abstract PDF Supplementary Material PubReader ePub: Purpose
The nProfiler 1 Stomach Cancer Assay (nProfiler1), designed to predict responses to fluorouracil-based adjuvant chemotherapy, measures the expression of four gastric cancer target genes (GZMB, WARS, SFRP4, and CDX1). The randomized phase III POST trial aimed to compare the efficacies of two adjuvant S-1-based doublet chemotherapies: S-1 plus cisplatin (SP) and S-1 plus docetaxel (DS). This study aimed to validate the nProfiler1 assay using a distinct cohort from the POST trial.
Materials and Methods
The nProfiler1 assay stratifies patients into three groups (low-risk, intermediate-risk, and high-risk) using the prognostic single-patient classifier and two groups (chemotherapy-benefit and no-benefit) using the predictive single-patient classifier. The nProfiler1 assay was applied to formalin-fixed paraffin-embedded slides obtained from the POST trial. Disease-free survival (DFS) and overall survival (OS), including 5-year survival rates, were calculated for the enrolled patients.
Results
Of the 153 patients in the POST trial, 118 were included in the post-hoc analysis. With a median follow-up of 57.9 months, no significant difference in DFS or OS was observed between the SP and DS groups. The prognostic single-patient classifier predicted the OS in the SP group (p=0.043) but not in the DS group (p=0.594). The chemotherapy-benefit group exhibited numerically longer DFS than the no-benefit group in the SP and DS groups.
Conclusion
The nProfiler1 assay offers valuable insights into the prognosis and efficacy of adjuvant chemotherapy based on fluorouracil plus platinum doublet regimens but not docetaxel-containing regimens. Further validation with larger patient cohorts and different regimens is warranted.

3,893 View
156 Download

Prognostic Factors and Scoring Model for Survival in Metastatic Biliary Tract Cancer: Hyung Soon Park, Ji Soo Park, You Jin Chun, Yun Ho Roh, Jieun Moon, Hong Jae Chon, Hye Jin Choi, Joon Seong Park, Dong Ki Lee, Se-Joon Lee, Dong Sup Yoon, Hei-Cheul Jeung; Cancer Res Treat. 2017;49(4):1127-1139. Published online February 6, 2017; DOI: https://doi.org/10.4143/crt.2016.538

Abstract PDF Supplementary Material PubReader ePub

Purpose
Metastatic biliary tract cancer (mBTC) has a dismal prognosis. In this study, an independent dataset of patients with mBTC was used to implement and validate a routine clinico-laboratory parameter-based scoring model for risk group identification.
Materials and Methods
From September 2006 to February 2015, 482 patients with mBTC were assigned randomly (ratio, 7:3) into investigational (n=340) and validation datasets (n=142). The continuous variables were dichotomized using a normal range or the best cutoff values determined using the Contal and O'Quigley statistical methods. Following a Cox’s proportional hazard model, the scoring model was derived by summing the rounded chi-square scores for the factors identified by multivariate analysis.
Results
The performance status (Eastern Cooperative Oncology Group 3-4), hypoalbuminemia (< 3.4 mg/dL), carcinoembryonic antigen (≥ 9 ng/mL), neutrophil-to-lymphocyte ratio (≥ 3.0), and carbohydrate antigen 19-9 (≥ 120 U/mL) were identified as independent prognosticators (Harrell’s C index, 0.682; integrated area under the curve, 0.653). Survival was clearly correlated with the risk groups (low, intermediate, and high, 14.0, 7.3, and 2.3 months, respectively; p < 0.001). The prognosis was also discriminative in the validation data set (median survival, 16.7, 7.5, and 1.9 months, respectively; p < 0.001). Chemotherapy did not offer any survival benefits for high-risk patients.
Conclusion
These proposed prognostic criteria for mBTC can facilitate accurate patient risk stratification and treatment-related decision-making.

Citations

Citations to this article as recorded by

Integrated CT-based assessment of muscle and adiposity for risk stratification in advanced pancreatobiliary cancer
Se Eung Oh, Sang Uk Han, Ye Seul Seong, Yoo Eun Yoon, Yeon Gil Jeong, Ji Soo Park, Ik Jae Lee, Hei-Cheul Jeung
Frontiers in Nutrition.2026;[Epub] CrossRef
Prognostic impact of neutrophil-to-lymphocyte ratio (NLR) in patients with unresectable biliary tract cancer treated with gemcitabine, cisplatin, and durvalumab
Satoshi Mii, Hiroyuki Kato, Takeshi Takahara, Masayuki Kojima, Yutaro Kato, Zenichi Morise, Akihiko Horiguchi, Koichi Suda
World Journal of Surgical Oncology.2025;[Epub] CrossRef
Comparison of clinical features by primary site in patients with biliary tract cancer who received gemcitabine-based chemotherapy: an exploratory analysis of JCOG1113
Yuko Suzuki, Masafumi Ikeda, Junki Mizusawa, Yusuke Sano, Chigusa Morizane, Takuji Okusaka, Satoshi Kobayashi, Hiroshi Imaoka, Takeshi Terashima, Naohiro Okano, Haruo Miwa, Akiko Todaka, Satoshi Shimizu, Nobumasa Mizuno, Sohei Satoi, Keiji Sano, Kazutoshi
International Journal of Clinical Oncology.2025; 30(10): 2053. CrossRef
A Single-Arm Phase II Study of Nab-Paclitaxel Plus Gemcitabine and Cisplatin for Locally Advanced or Metastatic Biliary Tract Cancer
Ting Liu, Qing Li, Zhen Lin, Chunhua Liu, Wei Pu, Shasha Zeng, Jun Lai, Xuebin Cai, Lisha Zhang, Shuyang Wang, Miao Chen, Wei Cao, Hongfeng Gou, Qing Zhu
Cancer Research and Treatment.2024; 56(2): 602. CrossRef
Novel Prognostic Model Construction of Tongue Squamous Cell Carcinoma Based on Apigenin-Associated Genes
Jianfei Lai, Chen Fang, Guohua Zhang, Chao Shi, Feng Yu, Weiguo Gu, Jianxiong Deng, Jingbiao Xu, Chaoxing Liu, Feng Qiu
Frontiers in Bioscience-Landmark.2024;[Epub] CrossRef
Survival Analysis of 1140 Patients with Biliary Cancer and Benefit from Concurrent Renin-Angiotensin Antagonists, Statins, or Aspirin with Systemic Therapy
Valerie Gunchick, Rachel L McDevitt, Elizabeth Choi, Katherine Winslow, Mark M Zalupski, Vaibhav Sahai
The Oncologist.2023; 28(6): 531. CrossRef
Development of a nomogram to predict survival in advanced biliary tract cancer
Hiroshi Imaoka, Masafumi Ikeda, Shogo Nomura, Chigusa Morizane, Takuji Okusaka, Masato Ozaka, Satoshi Shimizu, Kentaro Yamazaki, Naohiro Okano, Kazuya Sugimori, Hirofumi Shirakawa, Nobumasa Mizuno, Sohei Satoi, Hironori Yamaguchi, Rie Sugimoto, Kunihito G
Scientific Reports.2023;[Epub] CrossRef
Prognostic Role of a New Index Tested in European and Korean Advanced Biliary Tract Cancer Patients: the PECS Index
Giulia Rovesti, Francesco Leone, Giovanni Brandi, Lorenzo Fornaro, Mario Scartozzi, Monica Niger, Changhoon Yoo, Francesco Caputo, Roberto Filippi, Mariaelena Casagrande, Nicola Silvestris, Daniele Santini, Luca Faloppi, Andrea Palloni, Massimo Aglietta,
Journal of Gastrointestinal Cancer.2022; 53(2): 289. CrossRef
Clinical insights and prognostic factors from an advanced biliary tract cancer case series: a real-world analysis
Roberto Filippi, Francesco Leone, Lorenzo Fornaro, Giuseppe Aprile, Andrea Casadei-Gardini, Nicola Silvestris, Andrea Palloni, Maria Antonietta Satolli, Mario Scartozzi, Marco Russano, Stefania Eufemia Lutrino, Pasquale Lombardi, Giorgio Frega, Silvio Ken
Journal of Chemotherapy.2022; 34(2): 123. CrossRef
Cell-Free Tumor DNA Dominant Clone Allele Frequency Is Associated With Poor Outcomes in Advanced Biliary Cancers Treated With Platinum-Based Chemotherapy
Pedro Luiz Serrano Uson Junior, Umair Majeed, Jun Yin, Gehan Botrus, Mohamad Bassam Sonbol, Daniel H. Ahn, Jason S. Starr, Jeremy C. Jones, Hani Babiker, Samantha R. Inabinett, Natasha Wylie, Ashton W.R. Boyle, Tanios S. Bekaii-Saab, Gregory J. Gores, Ror
JCO Precision Oncology.2022;[Epub] CrossRef
Pre-treatment Nutritional Risk Assessment by NRS-2002 Predicts Prognosis in Patients With Advanced Biliary Tract Cancer: A Single Center Retrospective Study
Se Eung Oh, Juong Soon Park, Hei-Cheul Jeung
Clinical Nutrition Research.2022; 11(3): 183. CrossRef
Clinical epidemiology of gallbladder cancer in North-Central India and association of immunological markers, NLR, MLR and PLR in the diagnostic/prognostic prediction of GBC
Jyotsna Singh, Durgesh Shukla, Sanjiv Gupta, Braj Raj Shrivastav, Pramod Kumar Tiwari
Cancer Treatment and Research Communications.2021; 28: 100431. CrossRef
A prognostic model in patients with advanced biliary tract cancer receiving first-line chemotherapy
Roberto Filippi, Francesco Montagnani, Pasquale Lombardi, Lorenzo Fornaro, Giuseppe Aprile, Andrea Casadei-Gardini, Luca Faloppi, Andrea Palloni, Maria Antonietta Satolli, Mario Scartozzi, Fabrizio Citarella, Stefania Eufemia Lutrino, Caterina Vivaldi, Ni
Acta Oncologica.2021; 60(10): 1317. CrossRef
Second-line therapies in advanced biliary tract cancers
Sri Harsha Tella, Anuhya Kommalapati, Mitesh J Borad, Amit Mahipal
The Lancet Oncology.2020; 21(1): e29. CrossRef
The neonatal Fc receptor in cancer FcRn in cancer
Diana Cadena Castaneda, Guillaume Brachet, Caroline Goupille, Lobna Ouldamer, Valérie Gouilleux‐Gruart
Cancer Medicine.2020; 9(13): 4736. CrossRef
Prognostic Significance of Sarcopenia in Advanced Biliary Tract Cancer Patients
Byung min Lee, Yeona Cho, Jun Won Kim, Hei Cheul Jeung, Ik Jae Lee
Frontiers in Oncology.2020;[Epub] CrossRef
Construction of a Five-Super-Enhancer-Associated-Genes Prognostic Model for Osteosarcoma Patients
Zhanbo Ouyang, Guohua Li, Haihong Zhu, Jiaojiao Wang, Tingting Qi, Qiang Qu, Chao Tu, Jian Qu, Qiong Lu
Frontiers in Cell and Developmental Biology.2020;[Epub] CrossRef
Predictive factors of the treatment outcome in patients with advanced biliary tract cancer receiving gemcitabine plus cisplatin as first-line chemotherapy
Yuko Suzuki, Motoyasu Kan, Gen Kimura, Kumiko Umemoto, Kazuo Watanabe, Mitsuhito Sasaki, Hideaki Takahashi, Yusuke Hashimoto, Hiroshi Imaoka, Izumi Ohno, Shuichi Mitsunaga, Masafumi Ikeda
Journal of Gastroenterology.2019; 54(3): 281. CrossRef
Therapeutic outcomes and prognostic factors in unresectable gallbladder cancer treated with gemcitabine plus cisplatin
Min su You, Ji Kon Ryu, Young Hoon Choi, Jin Ho Choi, Gunn Huh, Woo Hyun Paik, Sang Hyub Lee, Yong-Tae Kim
BMC Cancer.2019;[Epub] CrossRef
Significance of serum ferritin as a prognostic factor in advanced hepatobiliary cancer patients treated with Korean medicine: a retrospective cohort study
Anna Song, Wankyu Eo, Sehyun Kim, Bumsang Shim, Sookyung Lee
BMC Complementary and Alternative Medicine.2018;[Epub] CrossRef
Platelet to lymphocyte ratio in biliary tract cancer: Review and meta-analysis
Lin-hua Zhou, Xiao-feng Luo
Clinica Chimica Acta.2017; 474: 102. CrossRef

14,216 View
264 Download
20 Web of Science
21 Crossref

Prognostic Scoring Index for Patients with Metastatic Pancreatic Adenocarcinoma: Hyung Soon Park, Hye Sun Lee, Ji Soo Park, Joon Seong Park, Dong Ki Lee, Se-Joon Lee, Dong Sup Yoon, Min Goo Lee, Hei-Cheul Jeung; Cancer Res Treat. 2016;48(4):1253-1263. Published online February 3, 2016; DOI: https://doi.org/10.4143/crt.2015.400

Abstract PDF PubReader ePub

Purpose
This study focused on implementation of a prognostic scoring index based on clinico-laboratory parameters measured routinely on admission in metastatic pancreatic cancer patients.
Materials and Methods
Records from 403 patients of metastatic disease were analyzed retrospectively. Continuous variables were dichotomized according to the normal range or the best cut-off values statistically determined by Contal and O’Quigley method, and then analyzed in association with prognosis—overall survival (OS), using Cox’s proportional hazard model. Scores were calculated by summing the rounded chi-square scores for the factors that emerged in the multivariate analysis.
Results
Performance status, hemoglobin, leucocyte count, neutrophil-lymphocyte ratio, and carcinoembryonic antigen were independent factors for OS. When patients were divided into three risk groups according to these factors, median survival was 11.7, 6.2, and 1.3 months for the low, intermediate, and high-risk groups, respectively (p < 0.001). Palliative chemotherapy has a significant survival benefit for low and intermediate-risk patients (median OS; 12.5 months vs. 5.9 months, p < 0.001 and 8.0 months vs. 2.0 months, p < 0.001, respectively).
Conclusion
We advocate the use of a multivariable approach with continuous variables for prognostic modeling. Our index is helpful in accurate patient risk stratification and may aid in treatment selection.

Citations

Citations to this article as recorded by

Glucose-to-Lymphocyte Ratio (GLR) as an Independent Prognostic Factor in Patients with Resected Pancreatic Ductal Adenocarcinoma—Cohort Study
Su-Hyeong Park, In-Cheon Kang, Seung-Soo Hong, Ha-Yan Kim, Ho-Kyoung Hwang, Chang-Moo Kang
Cancers.2024; 16(10): 1844. CrossRef
Clinical Outcomes of Proton Beam Therapy for Unresectable Locally Advanced Pancreatic Cancer: A Single-Center Retrospective Study
Ichiro Seto, Hisashi Yamaguchi, Yoshiaki Takagawa, Yusuke Azami, Kanako Takayama, Motohisa Suzuki, Masanori Machida, Yuntao Dai, Nor Shazrina Binti Sulaiman, Yasuhiro Kikuchi, Takahiro Kato, Noriyuki Nishino, Yasushi Teranishi, Masao Murakami
Advances in Radiation Oncology.2024; 9(10): 101577. CrossRef
Predictors of Mortality in Patients with Advanced Cancer—A Systematic Review and Meta-Analysis
Catherine Owusuaa, Simone A. Dijkland, Daan Nieboer, Agnes van der Heide, Carin C. D. van der Rijt
Cancers.2022; 14(2): 328. CrossRef
Prognostic models to predict survival in patients with pancreatic cancer: a systematic review
Liane J. Ioannou, Ashika D. Maharaj, John R. Zalcberg, Jesse T. Loughnan, Daniel G. Croagh, Charles H. Pilgrim, David Goldstein, James G. Kench, Neil D. Merrett, Arul Earnest, Elizabeth A. Burmeister, Kate White, Rachel E. Neale, Sue M. Evans
HPB.2022; 24(8): 1201. CrossRef
Development of a Clinical–Biological Model to Assess Tumor Progression in Metastatic Pancreatic Cancer: Post Hoc Analysis of the PRODIGE4/ACCORD11 Trial
Julie Egea, Julia Salleron, Sophie Gourgou, Ahmet Ayav, Valérie Laurent, Béata Juzyna, Alexandre Harlé, Thierry Conroy, Aurélien Lambert
Cancers.2022; 14(20): 5068. CrossRef
Systemic Immune-Inflammation Index and Changes of Neutrophil-Lymphocyte Ratio as Prognostic Biomarkers for Patients With Pancreatic Cancer Treated With Immune Checkpoint Blockade
Jin Shang, Xiao Han, Haoran Zha, Haitao Tao, Xiaoyan Li, Fang Yuan, Guangying Chen, Lijie Wang, Junxun Ma, Yi Hu
Frontiers in Oncology.2021;[Epub] CrossRef
71/m in reduziertem Allgemeinzustand mit Sklerenikterus
M. Schönrock, M. Sinn
Der Onkologe.2021; 27(S1): 109. CrossRef
Inflammatory Biomarker Score Identifies Patients with Six-Fold Increased Risk of One-Year Mortality after Pancreatic Cancer
Alisa D. Kjaergaard, Inna M. Chen, Astrid Z. Johansen, Børge G. Nordestgaard, Stig E. Bojesen, Julia S. Johansen
Cancers.2021; 13(18): 4599. CrossRef
Peripheral Blood Cell Variables Related to Systemic Inflammation in Patients With Unresectable or Metastatic Pancreatic Cancer
Giuseppe Colloca, Antonella Venturino
Pancreas.2021; 50(8): 1131. CrossRef
The Neutrophil-to-Lymphocyte Ratio is a Prognostic Biomarker in An Ethnically Diverse Patient Population with Advanced Pancreatic Cancer
Michael Shusterman, Erin Jou, Andreas Kaubisch, Jennifer W. Chuy, Lakshmi Rajdev, Santiago Aparo, Justin Tang, Nitin Ohri, Abdissa Negassa, Sanjay Goel
Journal of Gastrointestinal Cancer.2020; 51(3): 868. CrossRef
Predicting mortality and adverse events in patients with advanced pancreatic cancer treated with palliative gemcitabine-based chemotherapy in a multicentre phase III randomized clinical trial: the APC-SAKK risk scores
Piera Gargiulo, Daniel Dietrich, Richard Herrmann, György Bodoky, Thomas Ruhstaller, Werner Scheithauer, Bengt Glimelius, Simona Berardi, Sandro Pignata, Peter Brauchli
Therapeutic Advances in Medical Oncology.2019;[Epub] CrossRef
Prognostic role of the neutrophil-to-lymphocyte ratio in pancreatic cancer: A meta-analysis containing 8252 patients
Yongping Zhou, Qian Wei, Junsheng Fan, Sijin Cheng, Wenzhou Ding, Zhiyuan Hua
Clinica Chimica Acta.2018; 479: 181. CrossRef
A Contemporary Review of the Treatment Landscape and the Role of Predictive and Prognostic Biomarkers in Pancreatic Adenocarcinoma
Irene S. Yu, Winson Y. Cheung
Canadian Journal of Gastroenterology and Hepatology.2018; 2018: 1. CrossRef
Declined Preoperative Aspartate Aminotransferase to Neutrophil Ratio Index Predicts Poor Prognosis in Patients with Intrahepatic Cholangiocarcinoma after Hepatectomy
Lingyun Liu, Wei Wang, Yi Zhang, Jianting Long, Zhaohui Zhang, Qiao Li, Bin Chen, Shaoqiang Li, Yunpeng Hua, Shunli Shen, Baogang Peng
Cancer Research and Treatment.2018; 50(2): 538. CrossRef
Preoperative Neutrophil-Lymphocyte and Lymphocyte-Monocyte Ratios Reflect Immune Cell Population Rearrangement in Resectable Pancreatic Cancer
Marek Sierzega, Marzena Lenart, Magdalena Rutkowska, Marta Surman, Bozenna Mytar, Andrzej Matyja, Maciej Siedlar, Jan Kulig
Annals of Surgical Oncology.2017; 24(3): 808. CrossRef
Overall Survival Prediction and Usefulness of Second-Line Chemotherapy in Advanced Pancreatic Adenocarcinoma
Angélique Vienot, Guillaume Beinse, Christophe Louvet, Louis de Mestier, Aurélia Meurisse, Francine Fein, Bruno Heyd, Denis Cleau, Christelle d’Engremont, Anne-Claire Dupont-Gossart, Zaher Lakkis, Christophe Tournigand, Olivier Bouché, Benoît Rousseau, Ci
JNCI: Journal of the National Cancer Institute.2017;[Epub] CrossRef
Current and future biomarkers for pancreatic adenocarcinoma
Sven H Loosen, Ulf P Neumann, Christian Trautwein, Christoph Roderburg, Tom Luedde
Tumor Biology.2017; 39(6): 101042831769223. CrossRef
Neutrophil-to-lymphocyte ratio as prognostic indicator in gastrointestinal cancers: a systematic review and meta-analysis
Randy C. Bowen, Nancy Ann B. Little, Joshua R. Harmer, Junjie Ma, Luke G. Mirabelli, Kyle D. Roller, Andrew Mackay Breivik, Emily Signor, Alec B. Miller, Hung T. Khong
Oncotarget.2017; 8(19): 32171. CrossRef

16,422 View
208 Download
16 Web of Science
18 Crossref

Gemcitabine Combined with Capecitabine Compared to Gemcitabine with or without Erlotinib as First-Line Chemotherapy in Patients with Advanced Pancreatic Cancer: Jae Yun Lim, Jang Ho Cho, Se Joon Lee, Dong Ki Lee, Dong Sup Yoon, Jae Yong Cho; Cancer Res Treat. 2015;47(2):266-273. Published online August 29, 2014; DOI: https://doi.org/10.4143/crt.2013.158

Abstract PDF PubReader ePub

Purpose
The purpose of this study is to retrospectively compare the efficacy and tolerability between three regimens for first-line chemotherapy—gemcitabine plus capecitabine (GEM-X), gemcitabine plus erlotinib (GEM-T), and gemcitabine monotherapy (GEM)—in patients with advanced pancreatic cancer. Materials and Methods There was a total of 127 patients who underwent chemotherapy for pancreatic cancer between January 2007 and November 2011 at our institution. Patients were treated with either GEM (gemcitabine 1,000 mg/m2 on days 1, 8, and 15 every 4 weeks), GEM-T (gemcitabine 1,000 mg/m2 on days 1 and 8 every 3 weeks and erlotinib 100 mg daily), or GEM-X (gemcitabine 1,000 mg/m2 on days 1 and 8 every 3 weeks and capecitabine 850 mg/m2 twice daily for 2 weeks followed by 1 week’s rest) as the first-line treatment. Progression-free survival (PFS), overall survival (OS), objective response rate (ORR), and toxicity were evaluated. Results The patient population was divided into groups depending on their first-line treatment: GEM (n=47), GEM-T (n=44), and GEM-X (n=36). GEM-X significantly improved ORR (21.2% vs. 12.7% and 15.9%), PFS (8.9 vs. 5.2 and 3.9 months; p < 0.001), and OS (12.1 vs. 10.4 and 9.9 months; p = 0.03) compared to GEM and GEM-T, respectively. There were higher incidences of some non-hematologic adverse events with GEM-X and GEM-T compared to GEM, but most were grade 1 or 2. Conclusion GEM-X presented better clinical efficacy and acceptable tolerability than GEM-T and GEM in advanced pancreatic cancers. It is worthy to further investigate which agent has a clinical advantage as a combination drug with gemcitabine in pancreatic cancer and to explore the predictive markers leading to personalize anti-cancer treatment.

Citations

Citations to this article as recorded by

Gemcitabine/nab-paclitaxel plus S-1 combination compared with gemcitabine/nab-paclitaxel in advanced pancreatic ductal adenocarcinoma: a retrospective study
Kuan-Yu Tseng, Chiann-Yi Hsu, Cheng-Han Wu, Yu-Hsuan Shih, Hsin-Chen Lin
Therapeutic Advances in Medical Oncology.2026;[Epub] CrossRef
Therapeutic pancreatic cancer biomarkers and pharmacogenetics
Ales Langer, Pavel Soucek, Veronika Vymetalkova, Cosmeri Rizzato, Stefania Bunduc, Ilias P. Nikas, Viktor Hlavac, Michal Kroupa, Riccardo Farinella, Daniele Campa, Beatrice Mohelnikova-Duchonova
Seminars in Cancer Biology.2025; 116: 31. CrossRef
Clinical efficacy and safety of erlotinib combined with chemotherapy in the treatment of advanced pancreatic cancer: A meta-analysis
Xiao-Yan Liu, Hong-Nian Pan, Yue Yu
World Journal of Gastrointestinal Surgery.2024; 16(3): 921. CrossRef
A Systematic Study of Novel Drug Delivery Mechanisms and Treatment Strategies for Pancreatic Cancer
Umme Hani, Riyaz Ali M. Osmani, Ayesha Siddiqua, Shadma Wahab, Sadia Batool, Hissana Ather, Norhan Shereba, Ali Alqahtani
Journal of Drug Delivery Science and Technology.2021; : 102539. CrossRef
Pharmacoeconomic Evaluation of Erlotinib for the Treatment of Pancreatic Cancer
Kunxi Bao, Xiaobing Li, Xiaojing He, Lingyan Jian
Clinical Therapeutics.2021; 43(6): 1107. CrossRef
Are ENT1/ENT1, NOTCH3, and miR-21 Reliable Prognostic Biomarkers in Patients with Resected Pancreatic Adenocarcinoma Treated with Adjuvant Gemcitabine Monotherapy?
Lucie Jiraskova, Ales Ryska, Erik Jurjen Duintjer Tebbens, Helena Hornychova, Filip Cecka, Frantisek Staud, Lukas Cerveny
Cancers.2019; 11(11): 1621. CrossRef
Gemcitabine–erlotinib versus gemcitabine–erlotinib–capecitabine in the first-line treatment of patients with metastatic pancreatic cancer: Efficacy and safety results of a phase IIb randomised study from the Spanish TTD Collaborative Group
Antonio Irigoyen, Javier Gallego, Carmen Guillén Ponce, Ruth Vera, Vega Iranzo, Inmaculada Ales, Sara Arévalo, Aleydis Pisa, Marta Martín, Antonieta Salud, Esther Falcó, Alberto Sáenz, José Luis Manzano Mozo, Gema Pulido, Joaquina Martínez Galán, Roberto
European Journal of Cancer.2017; 75: 73. CrossRef
New targeted therapies in pancreatic cancer
Andrada Seicean
World Journal of Gastroenterology.2015; 21(20): 6127. CrossRef

18,128 View
87 Download
16 Web of Science
8 Crossref

Hepatocelluar Carcinomas Presenting as Bone Metastasis: Jun Myeong Kim, Woo Ick Jang, Sa Joon Hong, Jong Inn Lee, Kwang Seon Song, Dong Ki Lee, Sang Ok Kwon, Young Hak Shim; J Korean Cancer Assoc. 1994;26(1):41-46.

Abstract PDF: We report here five cases of hepatocellular carcinoma with symptomatic bone meatastasis as initial presentation. All patients were men ranging from 60 to 73 years of age. Initial presentations were the result of pelvic mass(l case), chest wall mass(1 case), spinal cord compression (2 case) and pathologic fracture of femur(l case). Of these 5 cases, bone metastasis commonly involved in ribs(5 cases) and in spine(4 cases). Actually, hepatocellular carcinoma presented as symptomatic bone metastasis is extremely rare, eventhough bone metastasis from hepatocellular carcinoma is found in 3% to 20% at autopsy. Prognosis is generally poor but palliative treatment with surgery and/or radiation can be considered.

2,767 View
12 Download

First
Prev
Page of 1
Next
Last

Search