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1 "Chang-Hyun Kang"
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Original Article
Role of Postoperative Radiotherapy for Microscopic Margin Involvement in the Squamous Cell Carcinoma of Esophagus
Sanghyuk Song, Eui Kyu Chie, Hak Jae Kim, Chang-Hyun Kang, Young Tae Kim, Joo Hyun Kim, Charn Il Park
Cancer Res Treat. 2013;45(3):202-209.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.202
AbstractAbstract PDFPubReaderePub
PURPOSE
The objective of this study was to assess the effect of postoperative radiotherapy on the outcome of esophageal cancer with microscopically positive resection margin by comparing the results with those of patients with negative resection margin.
MATERIALS AND METHODS
Medical records of 88 patients treated with macroscopic resection followed by postoperative radiotherapy for stage II or III squamous cell carcinoma of the esophagus from June 1984 to March 2008 were reviewed. Twelve patients had received chemotherapy. Patients were classified into two groups based on resection margin status: negative resection margin (group A, n=66) and microscopically positive resection margin (group B, n=22). Median follow-up duration of living patients was 68 months (range, 18 to 115 months). Median total radiation dose of group A and group B was 51.5 Gy (range, 45 to 69 Gy) and 52.1 Gy (range, 45 to 64 Gy), respectively.
RESULTS
Median overall survival and disease-free survival were 15 and 10 months, respectively. The five-year overall survival, disease-free survival, and local control rates for group A and group B were 15.9% and 16.4%, 13.5% and 9.1%, and 76.3% and 69.6%, respectively. No statistically significant difference in terms of overall survival, disease-free survival, and local control (p=0.295, p=0.209, and p=0.731, respectively) was observed between group A and group B. Seven patients experienced toxicity of grade 3 or higher.
CONCLUSION
A significant portion of patients with margin involvement reached long term survival after addition of postoperative radiotherapy. These results suggest a potential role of postoperative radiotherapy, especially for patients with margin involvement.

Citations

Citations to this article as recorded by  
  • Efficacy of postoperative radiotherapy in esophageal squamous cell carcinoma patients with positive circumferential resection margin
    Reiko Otake, Akihiko Okamura, Kotaro Yamashita, Yu Imamura, Jun Kanamori, Ryotaro Kozuki, Keita Takahashi, Tasuku Toihata, Noriko Yamamoto, Takao Asari, Shinji Mine, Masayuki Watanabe
    Esophagus.2021; 18(2): 288.     CrossRef
  • The Impact of Adjuvant Postoperative Radiation Therapy and Chemotherapy on Survival After Esophagectomy for Esophageal Carcinoma
    Andrew T. Wong, Meng Shao, Justin Rineer, Anna Lee, David Schwartz, David Schreiber
    Annals of Surgery.2017; 265(6): 1146.     CrossRef
  • Alpha linolenic acid and oleic acid additively down-regulate malignant potential and positively cross-regulate AMPK/S6 axis in OE19 and OE33 esophageal cancer cells
    Hyun-Seuk Moon, Saime Batirel, Christos S. Mantzoros
    Metabolism.2014; 63(11): 1447.     CrossRef
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