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Original Article
Gastrointestinal cancer
Fecal Microbial Dysbiosis Is Associated with Colorectal Cancer Risk in a Korean Population
Jeongseon Kim, Madhawa Gunathilake, Hyun Yang Yeo, Jae Hwan Oh, Byung Chang Kim, Nayoung Han, Bun Kim, Hyojin Pyun, Mi Young Lim, Young-Do Nam, Hee Jin Chang
Cancer Res Treat. 2025;57(1):198-211.   Published online July 26, 2024
DOI: https://doi.org/10.4143/crt.2024.382
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The association between the fecal microbiota and colorectal cancer (CRC) risk has been suggested in epidemiologic studies. However, data from large-scale population-based studies are lacking.
Materials and Methods
In this case-control study, we recruited 283 CRC patients from the Center for Colorectal Cancer, National Cancer Center Hospital, Korea to perform 16S rRNA gene sequencing of fecal samples. A total of 283 age- and sex-matched healthy participants were selected from 890 cohort of healthy Koreans that are publicly available (PRJEB33905). The microbial dysbiosis index (MDI) was calculated based on the differentially abundant species. The association between MDI and CRC risk was observed using conditional logistic regression. Sparse Canonical Correlation Analysis was performed to integrate species data with microbial pathways obtained by PICRUSt2.
Results
There is a significant divergence of the microbial composition between CRC patients and controls (permutational multivariate analysis of variance p=0.001). Those who were in third tertile of the MDI showed a significantly increased risk of CRC in the total population (odds ratio [OR], 6.93; 95% confidence interval [CI], 3.98 to 12.06; p-trend < 0.001) compared to those in the lowest tertile. Similar results were found for men (OR, 6.28; 95% CI, 3.04 to 12.98; p-trend < 0.001) and women (OR, 7.39; 95% CI, 3.10 to 17.63; p-trend < 0.001). Bacteroides coprocola and Bacteroides plebeius species and 12 metabolic pathways were interrelated in healthy controls that explain 91% covariation across samples.
Conclusion
Dysbiosis in the fecal microbiota may be associated with an increased risk of CRC. Due to the potentially modifiable nature of the gut microbiota, our findings may have implications for CRC prevention among Koreans.
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Special Article
Guidelines for Cancer Care during the COVID-19 Pandemic in South Korea
Jii Bum Lee, Minkyu Jung, June Hyuk Kim, Bo Hyun Kim, Yeol Kim, Young Seok Kim, Byung Chang Kim, Jin Kim, Sung Ho Moon, Keon-Uk Park, Meerim Park, Hyeon Jin Park, Sung Hoon Sim, Hong Man Yoon, Soo Jung Lee, Eunyoung Lee, June Young Chun, Youn Kyung Chung, So-Youn Jung, Jinsoo Chung, Eun Sook Lee, Hyun Cheol Chung, Tak Yun, Sun Young Rha
Cancer Res Treat. 2021;53(2):323-329.   Published online March 15, 2021
DOI: https://doi.org/10.4143/crt.2020.1256
AbstractAbstract PDFPubReaderePub
At the end of 2019, the cause of pneumonia outbreaks in Wuhan, China, was identified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In February 2020, the World Health Organization named the disease cause by SARS-CoV-2 as coronavirus disease 2019 (COVID-19). In response to the pandemic, the Korean Cancer Association formed the COVID-19 task force to develop practice guidelines. This special article introduces the clinical practice guidelines for cancer patients which will help oncologists best manage cancer patients during the COVID-19 pandemic.

Citations

Citations to this article as recorded by  
  • Preoperative COVID-19 and Postoperative Mortality in Cancer Surgery: A South Korean Nationwide Study
    Jae-Woo Ju, Soo-Hyuk Yoon, Tak Kyu Oh, Ho-Jin Lee
    Annals of Surgical Oncology.2024; 31(10): 6394.     CrossRef
  • Impact of the COVID-19 Pandemic on Esophagogastroduodenoscopy and Gastric Cancer Claims in South Korea: A Nationwide, Population-Based Study
    Min Ah Suh, Su Bee Park, Min Seob Kwak, Jin Young Yoon, Jae Myung Cha
    Yonsei Medical Journal.2023; 64(9): 549.     CrossRef
  • The elderly population are more vulnerable for the management of colorectal cancer during the COVID-19 pandemic: a nationwide, population-based study
    Hong Sun Kang, Seung Hoon Jeon, Su Bee Park, Jin Young Youn, Min Seob Kwak, Jae Myung Cha
    Intestinal Research.2023; 21(4): 500.     CrossRef
  • Impact of Coronavirus Disease 2019 on Gastric Cancer Diagnosis and Stage: A Single-Institute Study in South Korea
    Moonki Hong, Mingee Choi, JiHyun Lee, Kyoo Hyun Kim, Hyunwook Kim, Choong-Kun Lee, Hyo Song Kim, Sun Young Rha, Gyu Young Pih, Yoon Jin Choi, Da Hyun Jung, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee, Minah Cho, Yoo Min Kim, Hyoung-Il Kim,
    Journal of Gastric Cancer.2023; 23(4): 574.     CrossRef
  • Health-Seeking Behavior Returning to Normalcy Overcoming COVID-19 Threat in Breast Cancer
    Eun-Gyeong Lee, Yireh Han, Dong-Eun Lee, Hyeong-Gon Moon, Hyoung Won Koh, Eun-Kyu Kim, So-Youn Jung
    Cancer Research and Treatment.2023; 55(4): 1222.     CrossRef
  • Adherence to Physical Distancing and Health Beliefs About COVID-19 Among Patients With Cancer
    Sajida Fawaz Hammoudi, Oli Ahmed, Hoyoung An, Youjin Hong, Myung Hee Ahn, Seockhoon Chung
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • To overcome medical gap in screening and surveillance of colorectal cancer during the COVID-19 pandemic
    Yoo Min Han
    Intestinal Research.2023; 21(4): 418.     CrossRef
  • COVID-19 pandemic: a new cause of unplanned interruption of radiotherapy in breast cancer patients
    Shiho Lee, Jaesung Heo
    Medical Oncology.2022;[Epub]     CrossRef
  • Impact of the COVID-19 Pandemic on Breast Cancer Management in Portugal: A Cross-Sectional Survey-Based Study of Medical Oncologists
    Diogo Alpuim Costa, José Guilherme Gonçalves Nobre, João Paulo Fernandes, Marta Vaz Batista, Ana Simas, Carolina Sales, Helena Gouveia, Leonor Abreu Ribeiro, Andreia Coelho, Margarida Brito, Mariana Inácio, André Cruz, Mónica Mariano, Joana Savva-Bordalo,
    Oncology and Therapy.2022; 10(1): 225.     CrossRef
  • Organisation of cancer care in troubling times: A scoping review of expert guidelines and their implementation during the COVID-19 pandemic
    Brenda Bogaert, Victoria Buisson, Zizis Kozlakidis, Pierre Saintigny
    Critical Reviews in Oncology/Hematology.2022; 173: 103656.     CrossRef
  • Surgical safety in the COVID-19 era: present and future considerations
    Young Il Kim, In Ja Park
    Annals of Surgical Treatment and Research.2022; 102(6): 295.     CrossRef
  • Effect of Cancer-Related Dysfunctional Beliefs About Sleep on Fear of Cancer Progression in the Coronavirus Pandemic
    Harin Kim, Inn-Kyu Cho, Dongin Lee, Kyumin Kim, Joohee Lee, Eulah Cho, C. Hyung Keun Park, Seockhoon Chung
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • Impact of the COVID-19 Pandemic on Gastric Cancer Screening in South Korea: Results From the Korean National Cancer Screening Survey (2017–2021)
    Kyeongmin Lee, Mina Suh, Jae Kwan Jun, Kui Son Choi
    Journal of Gastric Cancer.2022; 22(4): 297.     CrossRef
  • Changes in cancer screening before and during COVID‐19: findings from the Korean National Cancer Screening Survey 2019 and 2020
    Thao Thi Kim Trinh, Yun Yeong Lee, Mina Suh, Jae Kwan Jun, Kui Son Choi
    Epidemiology and Health.2022; 44: e2022051.     CrossRef
  • Treatment decision for cancer patients with fever during the coronavirus disease 2019 (COVID-19) pandemic
    In Hee Lee, Sung Ae Koh, Soo Jung Lee, Sun Ah Lee, Yoon Young Cho, Ji Yeon Lee, Jin Young Kim
    Yeungnam University Journal of Medicine.2021; 38(4): 344.     CrossRef
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Original Articles
Nomogram Development and External Validation for Predicting the Risk of Lymph Node Metastasis in T1 Colorectal Cancer
Jung Ryul Oh, Boram Park, Seongdae Lee, Kyung Su Han, Eui-Gon Youk, Doo-Han Lee, Do-Sun Kim, Doo-Seok Lee, Chang Won Hong, Byung Chang Kim, Bun Kim, Min Jung Kim, Sung Chan Park, Dae Kyung Sohn, Hee Jin Chang, Jae Hwan Oh
Cancer Res Treat. 2019;51(4):1275-1284.   Published online January 17, 2019
DOI: https://doi.org/10.4143/crt.2018.569
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Predicting lymph node metastasis (LNM) risk is crucial in determining further treatment strategies following endoscopic resection of T1 colorectal cancer (CRC). This study aimed to establish a new prediction model for the risk of LNM in T1 CRC patients.
Materials and Methods
The development set included 833 patients with T1 CRC who had undergone endoscopic (n=154) or surgical (n=679) resection at the National Cancer Center. The validation set included 722 T1 CRC patients who had undergone endoscopic (n=249) or surgical (n=473) resection at Daehang Hospital. A logistic regression model was used to construct the prediction model. To assess the performance of prediction model, discrimination was evaluated using the receiver operating characteristic (ROC) curves with area under the ROC curve (AUC), and calibration was assessed using the Hosmer-Lemeshow (HL) goodness-of-fit test.
Results
Five independent risk factors were determined in the multivariable model, including vascular invasion, high-grade histology, submucosal invasion, budding, and background adenoma. In final prediction model, the performance of the model was good that the AUC was 0.812 (95% confidence interval [CI], 0.770 to 0.855) and the HL chi-squared test statistic was 1.266 (p=0.737). In external validation, the performance was still good that the AUC was 0.771 (95% CI, 0.708 to 0.834) and the p-value of the HL chi-squared test was 0.040. We constructed the nomogram with the final prediction model.
Conclusion
We presented an externally validated new prediction model for LNM risk in T1 CRC patients, guiding decision making in determining whether additional surgery is required after endoscopic resection of T1 CRC.

Citations

Citations to this article as recorded by  
  • Risk stratification scores for lymph node metastases in T1 colorectal cancer—A systematic review
    Rakesh Quinn, Giuleta Jamsari, Ewan MacDermid
    Colorectal Disease.2025;[Epub]     CrossRef
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    Attila Ulkucu, Metincan Erkaya, Ekin Inal, Emre Gorgun
    The American Journal of Surgery.2025; 241: 116152.     CrossRef
  • Risk assessment in pT1 colorectal cancer
    Emma Jane Norton, Adrian C Bateman
    Journal of Clinical Pathology.2024; 77(4): 225.     CrossRef
  • Curative criteria for endoscopic treatment of colorectal cancer
    Lucille Quénéhervé, Mathieu Pioche, Jérémie Jacques
    Best Practice & Research Clinical Gastroenterology.2024; 68: 101883.     CrossRef
  • Commentary: An artificial intelligence prediction model outperforms conventional guidelines in predicting lymph node metastasis of T1 colorectal cancer
    Katsuro Ichimasa, Shin-ei Kudo, Khay Guan Yeoh
    Frontiers in Oncology.2024;[Epub]     CrossRef
  • Management after non-curative endoscopic resection of T1 rectal cancer
    Hao Dang, Daan A. Verhoeven, Jurjen J. Boonstra, Monique E. van Leerdam
    Best Practice & Research Clinical Gastroenterology.2024; 68: 101895.     CrossRef
  • A clinical-radiomics nomogram based on spectral CT multi-parameter images for preoperative prediction of lymph node metastasis in colorectal cancer
    Qian Li, Rui Hong, Ping Zhang, Liting Hou, Hailun Bao, Lin Bai, Jian Zhao
    Clinical & Experimental Metastasis.2024; 41(5): 639.     CrossRef
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    Kai Wang, Hui He, Yanyun Lin, Yanhong Zhang, Junguo Chen, Jiancong Hu, Xiaosheng He
    International Journal of Colorectal Disease.2024;[Epub]     CrossRef
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    Frontiers in Oncology.2024;[Epub]     CrossRef
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    Yunho Jung
    The Korean Journal of Internal Medicine.2024; 39(4): 563.     CrossRef
  • A Nomogram for Predicting Unplanned Intraoperative Hypothermia in Patients With Colorectal Cancer Undergoing Laparoscopic Colorectal Procedures
    Lupei Yan, Jingxing Tan, Hao Chen, Han Xiao, Yi Zhang, Qin Yao, Yuerong Li
    AORN Journal.2023;[Epub]     CrossRef
  • A proposal for grading the risk of lymph node metastasis after endoscopic resection of T1 colorectal cancer
    Zhenghua Piao, Rong Ge, Chunnian Wang
    International Journal of Colorectal Disease.2023;[Epub]     CrossRef
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    Gastrointestinal Endoscopy.2023; 97(6): 1119.     CrossRef
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    European Radiology.2023; 33(10): 6861.     CrossRef
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    Chao-Tao Tang, Jun Li, Peng Wang, You-Xiang Chen, Chun-Yan Zeng
    Surgical Endoscopy.2023; 37(10): 7444.     CrossRef
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    Karmele Saez de Gordoa, Maria Teresa Rodrigo-Calvo, Ivan Archilla, Sandra Lopez-Prades, Alba Diaz, Jordi Tarragona, Isidro Machado, Juan Ruiz Martín, Diana Zaffalon, Maria Daca-Alvarez, Maria Pellisé, Jordi Camps, Miriam Cuatrecasas
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    Pathology and Oncology Research.2022;[Epub]     CrossRef
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    Liselotte W. Zwager, Barbara A.J. Bastiaansen, Nahid S.M. Montazeri, Roel Hompes, Valeria Barresi, Katsuro Ichimasa, Hiroshi Kawachi, Isidro Machado, Tadahiko Masaki, Weiqi Sheng, Shinji Tanaka, Kazutomo Togashi, Chihiro Yasue, Paul Fockens, Leon M.G. Moo
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    Gastrointestinal Endoscopy.2022; 96(6): 1036.     CrossRef
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    Frontiers in Oncology.2021;[Epub]     CrossRef
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    Katsuro Ichimasa, Shin-ei Kudo, Hideyuki Miyachi, Yuta Kouyama, Masashi Misawa, Yuichi Mori
    Gut and Liver.2021; 15(6): 818.     CrossRef
  • Supervised Learning Based Systemic Inflammatory Markers Enable Accurate Additional Surgery for pT1NxM0 Colorectal Cancer: A Comparative Analysis of Two Practical Prediction Models for Lymph Node Metastasis
    Jinlian Jin, Haiyan Zhou, Shulin Sun, Zhe Tian, Haibing Ren, Jinwu Feng
    Cancer Management and Research.2021; Volume 13: 8967.     CrossRef
  • Risk factors and predictors of lymph nodes metastasis and distant metastasis in newly diagnosed T1 colorectal cancer
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    Cancer Medicine.2020; 9(14): 5095.     CrossRef
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    Shaobo Mo, Zheng Zhou, Weixing Dai, Wenqiang Xiang, Lingyu Han, Long Zhang, Renjie Wang, Sanjun Cai, Qingguo Li, Guoxiang Cai
    Clinical and Translational Medicine.2020; 10(1): 275.     CrossRef
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    Qing-Wei Zhang, Long-Ci Sun, Chao-Tao Tang, Qian Liang, Yang-Yang Zhou, Hui-Min Chen, Yun-Jie Gao, Zhi-Zheng Ge
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    Adriana Vaz Safatle-Ribeiro
    Digestive and Liver Disease.2020; 52(8): 918.     CrossRef
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    Wei Xu, Yazhou He, Yuming Wang, Xue Li, Jane Young, John P. A. Ioannidis, Malcolm G. Dunlop, Evropi Theodoratou
    BMC Medicine.2020;[Epub]     CrossRef
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  • 41 Web of Science
  • 39 Crossref
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Endoscopic Criteria for Evaluating Tumor Stage after Preoperative Chemoradiation Therapy in Locally Advanced Rectal Cancer
Kyung Su Han, Dae Kyung Sohn, Dae Yong Kim, Byung Chang Kim, Chang Won Hong, Hee Jin Chang, Sun Young Kim, Ji Yeon Baek, Sung Chan Park, Min Ju Kim, Jae Hwan Oh
Cancer Res Treat. 2016;48(2):567-573.   Published online September 22, 2015
DOI: https://doi.org/10.4143/crt.2015.195
AbstractAbstract PDFPubReaderePub
Purpose
Local excision may be an another option for selected patients with markedly down-staged rectal cancer after preoperative chemoradiation therapy (CRT), and proper evaluation of post-CRT tumor stage (ypT) is essential prior to local excision of these tumors. This study was designed to determine the correlations between endoscopic findings and ypT of rectal cancer.
Materials and Methods
In this study, 481 patients with locally advanced rectal cancer who underwent preoperative CRT followed by surgical resection between 2004 and 2013 at a single institution were evaluated retrospectively. Pathological good response (p-GR) was defined as ypT ≤ 1, and pathological minimal or no response (p-MR) as ypT ≥ 2. The patients were randomly classified according to two groups, a testing (n=193) and a validation (n=288) group. Endoscopic criteria were determined from endoscopic findings and ypT in the testing group and used in classifying patients in the validation group as achieving or not achieving p-GR.
Results
Based on findings in the testing group, the endoscopic criteria for p-GR included scarring, telangiectasia, and erythema, whereas criteria for p-MR included nodules, ulcers, strictures, and remnant tumors. In the validation group, the kappa statistic was 0.965 (p < 0.001), and the sensitivity, specificity, positive predictive value, and negative predictive value were 0.362, 0.963, 0.654, and 0.885, respectively.
Conclusion
The endoscopic criteria presented are easily applicable for evaluation of ypT after preoperative CRT for rectal cancer. These criteria may be used for selection of patients for local excision of down-staged rectal tumors, because patients with p-MR could be easily ruled out.

Citations

Citations to this article as recorded by  
  • The value of multimodality MR in T staging evaluation after neoadjuvant therapy for rectal cancer
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  • Oncologic Risk of Rectal Preservation Against Medical Advice After Chemoradiotherapy for Rectal Cancer: A Multicenter Comparative Cross‐Sectional Study with Rectal Preservation as Supported by Surgeon
    Kwang‐Seop Song, Sung Chan Park, Dae Kyung Sohn, Jae Hwan Oh, Min Jung Kim, Ji Won Park, Seung‐Bum Ryoo, Seung‐Yong Jeong, Kyu Joo Park, Heung‐Kwon Oh, Duck‐Woo Kim, Sung‐Bum Kang
    World Journal of Surgery.2019; 43(12): 3216.     CrossRef
  • Endoscopic assessment of tumor regression after preoperative chemoradiotherapy as a prognostic marker in locally advanced rectal cancer
    Dae Kyung Sohn, Kyung Su Han, Byung Chang Kim, Chang Won Hong, Hee Jin Chang, Ji Yeon Baek, Min Ju Kim, Sung Chan Park, Jae Hwan Oh, Dae Yong Kim
    Surgical Oncology.2017; 26(4): 453.     CrossRef
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    Rutger CH. Stijns, Mike-Stephen R. Tromp, Niek Hugen, Johannes HW de Wilt
    European Journal of Surgical Oncology.2017;[Epub]     CrossRef
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  • 9 Web of Science
  • 7 Crossref
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