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- Volume 52(2); April 2020
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Special Articles
- Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2017
- Seri Hong, Young-Joo Won, Young Ran Park, Kyu-Won Jung, Hyun-Joo Kong, Eun Sook Lee, The Community of Population-Based Regional Cancer Registries
- Cancer Res Treat. 2020;52(2):335-350. Published online March 16, 2020
- DOI: https://doi.org/10.4143/crt.2020.206
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Abstract
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ePub - Purpose
This study reports the cancer statistics and temporal trends in Korea on a nationwide scale, including incidence, survival, prevalence, and mortality in 2017.
Materials and Methods
The incidence, survival, and prevalence rates of cancer were evaluated using data from the Korea National Cancer Incidence Database from 1999 to 2017 with follow-up until December 31, 2018. Deaths from cancer were assessed using cause-of-death data from 1983 to 2017, obtained from Statistics Korea. Crude and age-standardized rates (ASRs) for incidence, mortality, and prevalence, and 5-year relative survival rates were calculated and trend analysis was performed.
Results
In 2017, newly diagnosed cancer cases and deaths from cancer numbered 232,255 (ASR, 264.4 per 100,000) and 78,863 (ASR, 76.6 per 100,000), respectively. The overall cancer incidence rates increased annually by 3.5% from 1999 to 2011 and decreased by 2.7% annually thereafter. Cancer mortality rates have been decreasing since 2002, by 2.8% annually. The 5-year relative survival rate for all patients diagnosed with cancer between 2013 and 2017 was 70.4%, which contributed to a prevalence of approximately 1.87 million cases by the end of 2017.
Conclusion
The burden of cancer measured by incidence and mortality rates have improved in Korea, with the exception of a few particular cancers that are associated with increasing incidence or mortality rates. However, cancer prevalence is increasing rapidly, with the dramatic improvement in survival during the past several years. Comprehensive cancer control strategies and efforts should continue, based on the changes of cancer statistics. -
Citations
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Journal of the American Medical Directors Association.2022; 23(10): 1634. CrossRef - Cognitive impairment in women newly diagnosed with thyroid cancer before treatment
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Maturitas.2022; 166: 35. CrossRef - Decreased Preoperative Serum AGR as a Diagnostic Marker of Poor Prognosis after Radical Surgery of Upper Urinary Tract and Bladder Cancers from a Pooled Analysis of 9,002 Patients
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Cancers.2022; 14(19): 4615. CrossRef - Identification of Biomarkers Associated with Liver Metastasis Progression from Colorectal Cancer Using Exosomal RNA Profiling
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Cancers.2022; 14(19): 4723. CrossRef - Fear of Cancer Recurrence and Its Negative Impact on Health-Related Quality of Life in Long-term Breast Cancer Survivors
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International Journal of Environmental Research and Public Health.2022; 20(1): 16. CrossRef - Clinical utilization of radiation therapy in Korea between 2017 and 2019
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Epidemiology and Health.2022; 44: e2022072. CrossRef - Clinical Spectrum of Uveal Metastasis in Korean Patients Based on Primary Tumor Origin
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Ophthalmology Retina.2021; 5(6): 543. CrossRef - Environmental exposure to cadmium and risk of thyroid cancer from national industrial complex areas: A population-based cohort study
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Chemosphere.2021; 268: 128819. CrossRef - Conditional relative survival of cervical cancer: a Korean National Cancer Registry Study
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JMIR Medical Informatics.2021; 9(3): e25635. CrossRef - Conditional Relative Survival and Competing Mortality of Patients with Prostate Cancer in Korea: A Nationwide Cohort Study
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Cancer Epidemiology, Biomarkers & Prevention.2021; 30(2): 326. CrossRef - MicroRNA Profile for Diagnostic and Prognostic Biomarkers in Thyroid Cancer
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Cancers.2021; 13(4): 876. CrossRef - Different effects of p53 protein overexpression on the survival of gastric cancer patients according to Lauren histologic classification: a retrospective study
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Journal of Breast Cancer.2021; 24(1): 97. CrossRef - Therapeutic Status and Available Strategies in Pancreatic Ductal Adenocarcinoma
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Biomedicines.2021; 9(2): 178. CrossRef - Changes in Metabolic Syndrome Status and Breast Cancer Risk: A Nationwide Cohort Study
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Cancers.2021; 13(5): 1177. CrossRef - Comparing short-term outcomes after totally laparoscopic distal gastrectomy and laparoscopy-assisted distal gastrectomy with Billroth I anastomosis: early experience of a single institution
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The Journal of Minimally Invasive Surgery.2021; 24(1): 26. CrossRef - Association Rules of Comorbidities in Patients Hospitalized for Lung Cancer
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Journal of Health Informatics and Statistics.2021; 46(1): 100. CrossRef - Clinical outcomes of liposomal irinotecan plus fluorouracil/leucovorin for metastatic pancreatic adenocarcinoma in patients previously treated with conventional irinotecan-containing chemotherapy
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Therapeutic Advances in Medical Oncology.2021;[Epub] CrossRef - MicroRNA-552 expression in colorectal cancer and its clinicopathological significance
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Journal of Pathology and Translational Medicine.2021; 55(2): 125. CrossRef - Forearm Muscle Activity Patterns during Open Thyroidectomy Using 8-Channel Surface Electromyography
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Journal of Liver Cancer.2021; 21(1): 69. CrossRef - Nuclear Factor Erythroid 2-related Factor 2 Knockout Suppresses the Development of Aggressive Colorectal Cancer Formation Induced by Azoxymethane/Dextran Sulfate Sodium-Treatment in Female Mice
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Journal of Cancer Prevention.2021; 26(1): 41. CrossRef - Prediction of Cancer Incidence and Mortality in Korea, 2021
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Cancer Research and Treatment.2021; 53(2): 316. CrossRef - The mediating effect of resilience on happiness of advanced lung cancer patients
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Supportive Care in Cancer.2021; 29(11): 6217. CrossRef - Analysis of HPV Prevalence in Pairs of Cervical and Urine Samples from the Same Woman
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Biomedical Science Letters.2021; 27(1): 28. CrossRef - Second Primary Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancers after Breast Cancer Diagnosis: Korea Central Cancer Registry
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PLOS ONE.2021; 16(4): e0250716. CrossRef - Risk of female-specific cancers according to obesity and menopausal status in 2•7 million Korean women: Similar trends between Korean and Western women
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Cancer Medicine.2021; 10(10): 3249. CrossRef - Clinical Implication of Liquid Biopsy in Colorectal Cancer Patients Treated with Metastasectomy
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Yonsei Medical Journal.2021; 62(6): 479. CrossRef - Long-term effect of simplified dietary education on the nutritional status of patients after a gastrectomy
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Occupational and Environmental Medicine.2021; 78(12): 876. CrossRef - Endoscopic Screening and Surveillance for Gastric Cancer
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Gastrointestinal Endoscopy Clinics of North America.2021; 31(3): 489. CrossRef - Metastatic gastric cancer of the testis diagnosed through urine cytology
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International Journal of Environmental Research and Public Health.2021; 18(12): 6409. CrossRef - Is time-to-treatment associated with higher mortality in Korean elderly lung cancer patients?
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Health Policy.2021; 125(8): 1047. CrossRef - Patterns of Locoregional Recurrence after Radical Cystectomy for Stage T3-4 Bladder Cancer: A Radiation Oncologist's Point of View
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Korean Journal of Adult Nursing.2021; 33(3): 259. CrossRef - Changes in Korean National Healthcare Insurance Policy and Breast Cancer Surgery Trend in Korea
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Cancer Research and Treatment.2021; 53(3): 650. CrossRef - Clinicopathologic features of cutaneous metastases from internal malignancies
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Frontiers in Oncology.2021;[Epub] CrossRef - Stepwise-Hierarchical Pooled Analysis for Synergistic Interpretation of Meta-analyses Involving Randomized and Observational Studies: Methodology Development
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Scandinavian Journal of Gastroenterology.2021; 56(10): 1182. CrossRef - 3 Cases of Cancer Patients Whose Natural Killer Cell Activity Improved with Traditional Korean Medicine Treatment: A Case Series
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The Journal of Internal Korean Medicine.2021; 42(3): 444. CrossRef - The prognostic value of the pretreatment serum albumin to globulin ratio for predicting adverse pathology in patients undergoing radical prostatectomy for prostate cancer
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Cancer Epidemiology.2021; 74: 102000. CrossRef - Seasonal variations in the diagnosis of the top 10 cancers in Korea: A nationwide population‐based study using a common data model
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European Journal of Oncology Nursing.2021; 54: 102014. CrossRef - Microsatellite Instability and Effectiveness of Adjuvant Treatment in pT1N1 Gastric Cancer: A Multicohort Study
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Cancer Control.2021;[Epub] CrossRef - Association of Multifocality With Prognosis of Papillary Thyroid Carcinoma
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JAMA Otolaryngology–Head & Neck Surgery.2021; 147(10): 847. CrossRef - Characteristics of Patients Presenting to a Psycho-Oncology Outpatient Clinic
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Psychiatry Investigation.2021; 18(8): 743. CrossRef - Insomnia, Anxiety, and Depression in Patients First Diagnosed With Female Cancer
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Psychiatry Investigation.2021; 18(8): 755. CrossRef - Cost-Effectiveness Analysis of Active Surveillance Compared to Early Surgery in Small Papillary Thyroid Cancer: A Systemic Review
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Cancer Management and Research.2021; Volume 13: 6721. CrossRef - Patient-Level Cancer Prediction Models From a Nationwide Patient Cohort: Model Development and Validation
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JMIR Medical Informatics.2021; 9(8): e29807. CrossRef - International comparison of trends in cancer mortality: Japan has fallen behind in screening-related cancers
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International Journal of Environmental Research and Public Health.2021; 18(17): 9247. CrossRef - Metabolic Effects of Gastrectomy and Duodenal Bypass in Early Gastric Cancer Patients with T2DM: A Prospective Single-Center Cohort Study
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Journal of Clinical Medicine.2021; 10(17): 4008. CrossRef - Elevated Neutrophil-to-Lymphocyte Ratio in Perioperative Periods is Suggestive of Poor Prognosis in Patients with Colorectal Cancer
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Journal of Inflammation Research.2021; Volume 14: 4457. CrossRef - Single Surgeon Experience with 500 Cases of the Robotic Bilateral Axillary Breast Approach (BABA) for Thyroid Surgery Using the Da-Vinci Xi System
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Journal of Clinical Medicine.2021; 10(18): 4048. CrossRef - Comparison of clinicopathological characteristics and prognosis in breast cancer patients with different Breast Imaging Reporting and Data System categories
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Annals of Surgical Treatment and Research.2021; 101(3): 131. CrossRef - Characterization of Circulating IL-7R Positive Cell Populations for Early Detection of Pancreatic Ductal Adenocarcinoma
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Journal of Clinical Medicine.2021; 10(18): 4157. CrossRef - A nationwide study of patients with monoclonal gammopathy of undetermined significance with a 10-year follow-up in South Korea
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Scientific Reports.2021;[Epub] CrossRef - The incidence and survival of cervical, ovarian, and endometrial cancer in Korea, 1999-2017: Korea Central Cancer Registry
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Obstetrics & Gynecology Science.2021; 64(5): 444. CrossRef - Ramucirumab plus paclitaxel as second-line treatment in patients with advanced gastric or gastroesophageal junction adenocarcinoma: a nationwide real-world outcomes in Korea study (KCSG-ST19-16)
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Therapeutic Advances in Medical Oncology.2021;[Epub] CrossRef - Mobile Phone Use and Time Trend of Brain Cancer Incidence Rate in Korea
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Bioelectromagnetics.2021; 42(8): 629. CrossRef - Trends in the Incidence and Survival Rates of Colorectal Signet-Ring Cell Carcinoma in the South Korean Population: Analysis of the Korea Central Cancer Registry Database
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Journal of Clinical Medicine.2021; 10(18): 4258. CrossRef - Clinical Outcomes of Endoscopic Submucosal Dissection for Early Gastric Cancer in Patients with Comorbidities
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Gynecologic Oncology.2021; 163(3): 506. CrossRef - Barriers and strategies for cervical cancer screening: What do female university students know and want?
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PLOS ONE.2021; 16(10): e0257529. CrossRef - Analysis of the Occurrence of Diseases Following Gastrectomy for Early Gastric Cancer: a Nationwide Claims Study
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Asian Oncology Nursing.2021; 21(3): 173. CrossRef - Pulmonary Metastasectomy in Colorectal Cancer: A Population-Based Retrospective Cohort Study Using the Korean National Health Insurance Database
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Cancer Research and Treatment.2021; 53(4): 1104. CrossRef - Genomic Instability of Circulating Tumor DNA as a Prognostic Marker for Pancreatic Cancer Survival: A Prospective Cohort Study
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Cancers.2021; 13(21): 5466. CrossRef - Epidemiologic trends in cancer-related emergency department utilization in Korea from 2015 to 2019
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Scientific Reports.2021;[Epub] CrossRef - Screening Plasma Exosomal RNAs as Diagnostic Markers for Cervical Cancer: An Analysis of Patients Who Underwent Primary Chemoradiotherapy
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Biomolecules.2021; 11(11): 1691. CrossRef - Spatial epidemiologic analysis of the liver cancer and gallbladder cancer incidence and its determinants in South Korea
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BMC Public Health.2021;[Epub] CrossRef - Temporal trend of gastric cancer burden along with its risk factors in China from 1990 to 2019, and projections until 2030: comparison with Japan, South Korea, and Mongolia
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Biomarker Research.2021;[Epub] CrossRef - Inhibition of the bromodomain and extra-terminal family of epigenetic regulators as a promising therapeutic approach for gastric cancer
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- Prediction of Cancer Incidence and Mortality in Korea, 2020
- Kyu-Won Jung, Young-Joo Won, Seri Hong, Hyun-Joo Kong, Eun Sook Lee
- Cancer Res Treat. 2020;52(2):351-358. Published online March 16, 2020
- DOI: https://doi.org/10.4143/crt.2020.203
-
Abstract
PDFPubReaderePub
- Purpose
This study aimed to report the projected cancer incidence and mortality for the year 2020 to estimate Korea’s current cancer burden.
Materials and Methods
Cancer incidence data from 1999 to 2017 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2018 were acquired from Statistics Korea. Cancer incidence and mortality were projected by fitting a linear regression model to observed age-specific cancer rates against observed years and then by multiplying the projected age-specific rates by the age-specific population. A Joinpoint regression model was used to determine the year in which the linear trend changed significantly; we only used the data of the latest trend.
Results
In total, 243,263 new cancer cases and 80,546 cancer deaths are expected to occur in Korea in 2020. The most common cancer site is expected to be the lung, followed by the stomach, thyroid, colon/rectum, and breast. These five cancers types are expected to represent half of the overall burden of cancer in Korea. The most common type of cancer among people who die is expected to be lung cancer, followed by liver, colon/rectal, pancreatic, and stomach cancers.
Conclusion
The incidence rates for all types of cancer in Korea are estimated to decrease gradually. These up-to-date estimates of the cancer burden in Korea could be an important resource for planning and evaluating cancer-control programs. -
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Original Articles
- Clinical Characteristics and Treatment Outcomes of Pediatric Patients with Non-Hodgkin Lymphoma in East Asia
- Jin Kyung Suh, Yi-Jin Gao, Jing-Yan Tang, Shiann-Tarng Jou, Dong-Tsamn Lin, Yoshiyuki Takahashi, Seiji Kojima, Ling Jin, Yonghong Zhang, Jong Jin Seo
- Cancer Res Treat. 2020;52(2):359-368. Published online July 29, 2019
- DOI: https://doi.org/10.4143/crt.2019.219
-
Abstract
PDFPubReaderePub
- Purpose
The presentations and geographic incidence of pediatric non-Hodgkin lymphoma (NHL) differ from those of adults. This study delineated the characteristics and outcomes of pediatric NHL in East Asia.
Materials and Methods
Medical records of 749 pediatric patients with NHL treated at participating institutions in mainland China, Japan, Korea, and Taiwan from January 2008 to December 2013 were reviewed. Demographic and clinical features, survival outcomes, and putative prognostic factors were analyzed.
Results
Five hundred thirty patients (71%) were male. The most common pathologic subtypes were Burkitt lymphoma (BL) (36%). Six hundred seven patients (81%) had advanced diseases at diagnosis. The 5-year overall survival and event-free survival (EFS) rates were 89% and 84%. The 5-year EFS rates of BL, lymphoblastic lymphoma, and diffuse large B-cell lymphoma were 88%, 88%, and 89%, and those of anaplastic large cell lymphoma (ALCL) and peripheral T-cell lymphoma (PTCL) were 71% and 56% (p < 0.001). Central nervous system involvement, high lactate dehydrogenase level (> 250 IU/mL), and advanced disease at diagnosis (≥ stage III) were associated with poor outcomes (p < 0.05). ALCL and PTCL relapsed more frequently than other pathologic subtypes (p < 0.001).
Conclusion
In East Asia, PTCL was more frequent than in Western countries, and bone marrow involvement did not affect treatment outcome. This international study should motivate future collaborative study on NHL in East Asia. -
Citations
Citations to this article as recorded by- Evaluation of NHL subtypes, staging, and prognostic factors: A single-centric retrospective cohort study
Ulfat A. Wani, Umeek Jeelani, Sheikh A. Aziz, Bashrat Ara Wani, Gul M. Bhat, Kaneez Fatima, Shaheen N. Lone, Asifa Andleeb
Journal of Cancer Research and Therapeutics.2025; 21(1): 34. CrossRef - Hemoglobinopathies, merozoite surface protein-2 gene polymorphisms, and acquisition of Epstein Barr virus among infants in Western Kenya
Perez K. Olewe, Shehu Shagari Awandu, Elly O. Munde, Samuel B. Anyona, Evans Raballah, Asito S. Amolo, Sidney Ogola, Erick Ndenga, Clinton O. Onyango, Rosemary Rochford, Douglas J. Perkins, Collins Ouma
BMC Cancer.2023;[Epub] CrossRef - iTRAQ-Based Proteomic Analysis Reveals Potential Serum Biomarkers for Pediatric Non-Hodgkin’s Lymphoma
Runhong Yu, Linna Cheng, Shiwei Yang, Yufeng Liu, Zunmin Zhu
Frontiers in Oncology.2022;[Epub] CrossRef
- Evaluation of NHL subtypes, staging, and prognostic factors: A single-centric retrospective cohort study
- 9,275 View
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- 3 Crossref
- Body Mass Index and Risk of Gastric Cancer in Asian Adults: A Meta-Epidemiological Meta-Analysis of Population-Based Cohort Studies
- Jong-Myon Bae
- Cancer Res Treat. 2020;52(2):369-373. Published online August 12, 2019
- DOI: https://doi.org/10.4143/crt.2019.241
-
Abstract
PDFPubReaderePub
- Purpose
A previous meta-analysis (MA) published in 2009 reported that excess body weight was associated with an increased risk of gastric cancer in non-Asians, but not in Asians. The aim was to conduct a meta-epidemiological MA (MEMA) to evaluate association between excess body weight and the risk of gastric cancer in Asian adults with using the proposed classification of weight by body mass index (BMI) in Asian adults.
Materials and Methods
The selection criteria were population-based prospective cohort studies that measured BMI of cohort participants and evaluated a risk of gastric cancer. Overweight group (OW) and obesity group (OB) were defined as 23.0-24.9 and ≥ 25.0, respectively. A group only showing results for BMI over 23.0 was defined as overweight and obesity group (OWB). Random effect model was applied if I2 value was over 50%.
Results
After four new studies were added through citation discovery tools, seven cohort studies with 21 datasets were selected finally for MEMA. The I2 value of OW, OB, and OWB were 76.1%, 83.5%, and 97.1%, respectively. Only OWB in men had a I2 value below 50% (22.5%) and showed a statistical significance with inverse association (summary relative risk, 0.79; 95% confidence interval, 0.77 to 0.81).
Conclusion
This MEMA supported the hypothesis that OW might be a protective factor in gastric cancer risk in Asian adults. It will be necessary to conduct additional cohort studies with lengthening follow-up periods and re-analyzing the effect of overweight and obesity classified by the Asian criteria. -
Citations
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Frontiers in Pharmacology.2022;[Epub] CrossRef - Metabolic syndrome, obesity and cancer risk
Federico Belladelli, Francesco Montorsi, Alberto Martini
Current Opinion in Urology.2022; 32(6): 594. CrossRef - Obesity as a Risk Factor for Different Cancers: Systematic Review
Abdelrahman Mohamed Ahmed Abukanna, Ziyad Mubarak S Alanazi, Amer Meshal H Alanazi, Atheer Humaidy S Alenazi, Abdulrahman Obaid A Alanazi, Khaloud Attaulla Alenezi, Gharam Mahmood Alsalmi
Clinical Cancer Investigation Journal.2022; 11(6): 45. CrossRef - Esophagogastric junction adenocarcinoma shares characteristics with gastric adenocarcinoma: Literature review and retrospective multicenter cohort study
Yu Imamura, Masayuki Watanabe, Eiji Oki, Masaru Morita, Hideo Baba
Annals of Gastroenterological Surgery.2021; 5(1): 46. CrossRef - Body composition and risk of gastric cancer: A population‐based prospective cohort study
An‐Ran Liu, Qiang‐Sheng He, Wen‐Hui Wu, Jian‐Liang Du, Zi‐Chong Kuo, Bin Xia, Yan Tang, Peng Yun, Eddie C. Cheung, You‐Zhen Tang, Yu‐Long He, Chang‐Hua Zhang, Jin‐Qiu Yuan, Gang Sun
Cancer Medicine.2021; 10(6): 2164. CrossRef - Gastric Cancer Epidemiology
Aaron P. Thrift, Theresa H. Nguyen
Gastrointestinal Endoscopy Clinics of North America.2021; 31(3): 425. CrossRef - Healthy Lifestyle Factors, Cancer Family History, and Gastric Cancer Risk: A Population-Based Case-Control Study in China
Jinyu Man, Yingchun Ni, Xiaorong Yang, Tongchao Zhang, Ziyu Yuan, Hui Chen, Xingdong Chen, Ming Lu, Weimin Ye
Frontiers in Nutrition.2021;[Epub] CrossRef
- Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts
- 7,286 View
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- 17 Web of Science
- 17 Crossref
- Efficacy of Brentuximab Vedotin in Relapsed or Refractory High-CD30–Expressing Non-Hodgkin Lymphomas: Results of a Multicenter, Open-Labeled Phase II Trial
- Seok Jin Kim, Dok Hyun Yoon, Jin Seok Kim, Hye Jin Kang, Hye Won Lee, Hyeon-Seok Eom, Jung Yong Hong, Junhun Cho, Young Hyeh Ko, Jooryung Huh, Woo-Ick Yang, Weon Seo Park, Seung-Sook Lee, Cheolwon Suh, Won Seog Kim
- Cancer Res Treat. 2020;52(2):374-387. Published online August 13, 2019
- DOI: https://doi.org/10.4143/crt.2019.198
-
Abstract
PDFPubReaderePub
- Purpose
The treatment outcome of brentuximab vedotin (BV) has not been related with CD30 expression in previous studies enrolling patients with a wide range of CD30 expression level. Thus, this study explored the efficacy of BV in high-CD30–expressing non-Hodgkin lymphoma (NHL) patients most likely to benefit.
Materials and Methods
This phase II study (Clinicaltrials.gov: NCT02280785) enrolled relapsed or refractory high-CD30–expressing NHL, with BV administered intravenously at 1.8 mg/kg every 3 weeks. The primary endpoint was > 40% disease control rate, consisting of complete response (CR), partial response (PR), or stable disease. We defined high CD30 expression as ≥ 30% tumor cells positive for CD30 by immunohistochemistry.
Results
High-CD30-expressing NHL patients (n=33) were enrolled except anaplastic large cell lymphoma. The disease control rate was 48.5% (16/33) including six CR and six PR; six patients (4CR, 2PR) maintained their response over 16 completed cycles. Response to BV and survival were not associated with CD30 expression levels. Over a median of 29.2 months of follow-up, the median progression-free and overall survival rates were 1.9 months and 6.1 months, respectively. The most common adverse events were fever (39%), neutropenia (30%), fatigue (24%), and peripheral sensory neuropathy (27%). In a post-hoc analysis for the association of multiple myeloma oncogene 1 (MUM1) on treatment outcome, MUM1- negative patients showed a higher response (55.6%, 5/9) than MUM1-positive patients (13.3%, 2/15).
Conclusion
BV performance as a single agent was acceptable in terms of disease control rates and toxicity profiles, especially MUM1-negative patients. -
Citations
Citations to this article as recorded by- Therapeutic Monoclonal Antibodies for Non-Hodgkin Lymphoma: A
Literature Review
Mohammad Sadegh Fallahi, Nasibeh Zerangian, Atousa Ghorbani, Gisou Erabi, Melika Shirali, Elaheh Shabani, Foad Rommasi, Mahsa Mohammadi Najafabadi, Shima Karbasi, Samaneh Toutounchian, Ramin Ahangar-Sirous, Ava Motaghy, Mahsa Heidari, Niloofar Deravi
Current Cancer Therapy Reviews.2024; 20(1): 53. CrossRef - Phase I/II clinical trial of brentuximab vedotin for pretreated Japanese patients with CD30‐positive cutaneous T‐cell lymphoma
Yoji Hirai, Jun Sakurai, Shiho Yoshida, Takashi Kikuchi, Toshiharu Mitsuhashi, Tomoko Miyake, Taku Fujimura, Riichiro Abe, Hiroki Fujikawa, Hikari Boki, Hiraku Suga, Sayaka Shibata, Tomomitsu Miyagaki, Takatoshi Shimauchi, Eiji Kiyohara, Yoshio Kawakami,
The Journal of Dermatology.2024; 51(8): 1037. CrossRef - Brentuximab vedotin therapy followed by autologous peripheral stem cell transplantation as a viable treatment option for an older adult with transformed lymphoma: a case report and literature review
Jiewen Tan, Jinman Zhong, Wanzhen Hu, Guobiao Wu, Chong Zeng, Dan Xiong
Journal of International Medical Research.2024;[Epub] CrossRef - Belantamab mafodotin concentration–QTc relationships in patients with relapsed or refractory multiple myeloma from the DREAMM‐1 and ‐2 studies
Roxanne C. Jewell, Richard J. Mills, Colm Farrell, Sandra A. G. Visser
British Journal of Clinical Pharmacology.2024;[Epub] CrossRef - Resistance mechanisms and potential therapeutic strategies in relapsed or refractory natural killer/T cell lymphoma
Chengji Wang, Liang Wang
Chinese Medical Journal.2024; 137(19): 2308. CrossRef - Research progress on EBV-associated NK/T cell lymphoma
Jun CAI, Yi CAO, LiYun QIU, Yan GAO, HuiQiang HUANG, QingQing CAI
SCIENTIA SINICA Vitae.2024; 54(12): 2363. CrossRef - Treatment of extranodal NK/T-cell lymphoma: From past to future
Zheng Yan, Shuna Yao, Zhizhong Wang, Wenping Zhou, Zhihua Yao, Yanyan Liu
Frontiers in Immunology.2023;[Epub] CrossRef - Rational Targets of Therapy in Extranodal NK/T-Cell Lymphoma
Ajay Major, Pierluigi Porcu, Bradley M. Haverkos
Cancers.2023; 15(5): 1366. CrossRef - Safety of Concurrent Radiation Therapy With Brentuximab Vedotin in the Treatment of Lymphoma
Susan Y. Wu, Penny Q. Fang, Ethan B. Wang, Sairah Ahmed, Madeleine Duvic, Preetesh Jain, Luis E. Malpica Castillo, Ranjit Nair, Raphael E. Steiner, Paolo Strati, Auris O. Huen, Swaminathan P. Iyer, Chelsea C. Pinnix, Bouthaina S. Dabaja, Jillian R. Gunthe
Advances in Radiation Oncology.2023; 8(6): 101279. CrossRef - Novel target and treatment agents for natural killer/T-cell lymphoma
Xiao-Peng Tian, Yi Cao, Jun Cai, Yu-Chen Zhang, Qi-Hua Zou, Jin-Ni Wang, Yu Fang, Jia-Hui Wang, Song-Bin Guo, Qing-Qing Cai
Journal of Hematology & Oncology.2023;[Epub] CrossRef - Treatment‐related adverse events of antibody‐drug conjugates in clinical trials: A systematic review and meta‐analysis
Jinming Li, Guoshuang Shen, Zhen Liu, Yaobang Liu, Miaozhou Wang, Fuxing Zhao, Dengfeng Ren, Qiqi Xie, Zitao Li, Zhilin Liu, Yi Zhao, Fei Ma, Xinlan Liu, Zhengbo Xu, Jiuda Zhao
Cancer Innovation.2023; 2(5): 346. CrossRef - Advances and challenges of immunotherapies in NK/T cell lymphomas
Ling He, Na Chen, Lei Dai, Xingchen Peng
iScience.2023; 26(11): 108192. CrossRef - Brentuximab vedotin in treating Chinese patients with lymphoma: A multicenter, real‐world study
Xudong Zhang, Honghan Qiao, Xiaofei Chai, Xue Gao, Rongjun Ma, Yufu Li, Zunmin Zhu, Mingzhi Zhang
Cancer Medicine.2023; 12(24): 21725. CrossRef - A multi-center and non-interventional registry of brentuximab vedotin in patients with relapsed or refractory CD30-positive lymphoma: the CISL1803/BRAVO study
Seok Jin Kim, Young Rok Do, Ho-Sup Lee, Won-Sik Lee, Jee Hyun Kong, Jae-Yong Kwak, Hyeon-Seok Eom, Joon Ho Moon, Jun Ho Yi, Jeong-Ok Lee, Jae-Cheol Jo, Deok-Hwan Yang
Blood Research.2023; 58(4): 194. CrossRef - Update on Molecular Diagnosis in Extranodal NK/T-Cell Lymphoma and Its Role in the Era of Personalized Medicine
Ka-Hei (Murphy) Sun, Yin-Ting (Heylie) Wong, Ka-Man (Carmen) Cheung, Carmen (Michelle) Yuen, Yun-Tat (Ted) Chan, Wing-Yan (Jennifer) Lai, Chun (David) Chao, Wing-Sum (Katie) Fan, Yuen-Kiu (Karen) Chow, Man-Fai Law, Ho-Chi (Tommy) Tam
Diagnostics.2022; 12(2): 409. CrossRef - Phase 1/dose expansion trial of brentuximab vedotin and lenalidomide in relapsed or refractory diffuse large B-cell lymphoma
Jeffrey P. Ward, Melissa M. Berrien-Elliott, Felicia Gomez, Jingqin Luo, Michelle Becker-Hapak, Amanda F. Cashen, Nina D. Wagner-Johnston, Kami Maddocks, Matthew Mosior, Mark Foster, Kilannin Krysiak, Alina Schmidt, Zachary L. Skidmore, Sweta Desai, Marcu
Blood.2022; 139(13): 1999. CrossRef - Monoclonal Antibodies in the Treatment of Diffuse Large B-Cell Lymphoma: Moving beyond Rituximab
Sotirios G. Papageorgiou, Thomas P. Thomopoulos, Athanasios Liaskas, Theodoros P. Vassilakopoulos
Cancers.2022; 14(8): 1917. CrossRef - Basic immunohistochemistry for lymphoma diagnosis
Junhun Cho
Blood Research.2022; 57(S1): S55. CrossRef - Extranodal Natural Killer/T-Cell Lymphomas: Current Approaches and Future Directions
John C. Reneau, Polina Shindiapina, Zachary Braunstein, Youssef Youssef, Miguel Ruiz, Saira Farid, Walter Hanel, Jonathan E. Brammer
Journal of Clinical Medicine.2022; 11(10): 2699. CrossRef - CD30 + Primary intestinal T-cell lymphoma (unclassified) masquerading as chronic inflammation: a case report
Kashif Osmani, Eshana Shah, Bradley Drumheller, Shaun Webb, Manmeet Singh, Paul Rubinstein, John Patrick Galvin, Megan S. Lim, Carlos Murga-Zamalloa
Diagnostic Pathology.2022;[Epub] CrossRef - EBV-associated NK and T-cell lymphoid neoplasms
Hiroshi Kimura, Laurence de Leval, Qingqing Cai, Won Seog Kim
Current Opinion in Oncology.2022; 34(5): 422. CrossRef - Intravascular NK/T-Cell Lymphoma: What We Know about This Diagnostically Challenging, Aggressive Disease
Magda Zanelli, Paola Parente, Francesca Sanguedolce, Maurizio Zizzo, Andrea Palicelli, Alessandra Bisagni, Illuminato Carosi, Domenico Trombetta, Luca Mastracci, Linda Ricci, Saverio Pancetti, Giovanni Martino, Giuseppe Broggi, Rosario Caltabiano, Alberto
Cancers.2022; 14(21): 5458. CrossRef - Extranodal natural killer/T-cell lymphoma: An overview on pathology and clinical management
Eric Tse, Christopher P. Fox, Alexander Glover, Sang Eun Yoon, Won Seog Kim, Yok-Lam Kwong
Seminars in Hematology.2022; 59(4): 198. CrossRef - Primary Mediastinal B-Cell Lymphoma: Novel Precision Therapies and Future Directions
Huan Chen, Tao Pan, Yizi He, Ruolan Zeng, Yajun Li, Liming Yi, Hui Zang, Siwei Chen, Qintong Duan, Ling Xiao, Hui Zhou
Frontiers in Oncology.2021;[Epub] CrossRef - NK-/T-cell lymphomas
Hua Wang, Bi-bo Fu, Robert Peter Gale, Yang Liang
Leukemia.2021; 35(9): 2460. CrossRef - The landscape of new drugs in extranodal NK/T-cell lymphoma
Liang Wang, Lin-Rong Li, Luo Zhang, Jing-Wen Wang
Cancer Treatment Reviews.2020; 89: 102065. CrossRef - Molecular insights into pathogenesis and targeted therapy of peripheral T cell lymphoma
Caiqin Xie, Xian Li, Hui Zeng, Wenbin Qian
Experimental Hematology & Oncology.2020;[Epub] CrossRef - New agents and regimens for diffuse large B cell lymphoma
Liang Wang, Lin-rong Li, Ken H. Young
Journal of Hematology & Oncology.2020;[Epub] CrossRef - A Phase II Study of Brentuximab Vedotin in Patients with Relapsed or Refractory Epstein-Barr Virus-Positive- and CD30-Positive Lymphomas
Miso Kim, Jeong-Ok Lee, Jiwon Koh, Tae Min Kim, Ji Yun Lee, Yoon Kyung Jeon, Bhumsuk Keam, Dong-Wan Kim, Jong Seok Lee, Dae Seog Heo
SSRN Electronic Journal .2020;[Epub] CrossRef
- Therapeutic Monoclonal Antibodies for Non-Hodgkin Lymphoma: A
Literature Review
- 10,384 View
- 633 Download
- 29 Web of Science
- 29 Crossref
- Displacement of Surgical Clips in Patients with Human Acellular Dermal Matrix in the Excision Cavity during Whole Breast Irradiation Following Breast-Conserving Surgery
- Wonguen Jung, Kyubo Kim, Nam Sun Paik
- Cancer Res Treat. 2020;52(2):388-395. Published online August 13, 2019
- DOI: https://doi.org/10.4143/crt.2019.213
-
Abstract
PDFPubReaderePub
- Purpose
The purpose of this study was to investigate the displacement of surgical clips in the excision cavity during whole breast irradiation following breast-conserving surgery (BCS) with or without acellular dermal matrix (ADM) insertion, and to analyze clinicopathologic factors associated with the displacement of surgical clips.
Materials and Methods
From 2016 to 2017, 100 consecutive breast cancer patients who underwent BCS with the placement of surgical clips (superior, inferior, medial, lateral, and deep sides) in the tumor bed were included in this study. All patients took first planning computed tomography (CT) scan (CT 1) before whole breast irradiation and second CT scan (CT 2) before boost irradiation. Between two sets of planning CT, the displacement of surgical clips was calculated from the ΔX (lateral–medial), ΔY (anterior–posterior), ΔZ (superior–inferior), and three-dimensional (3D) directions. Patients were divided into two groups according to the breast volume replacement with ADM: group A with ADM and group B without ADM.
Results
The means and 1 standard deviations of 3D displacement for superior, inferior, medial, lateral and deep clips were 5.2±2.9, 5.2±3.2, 5.6±4.5, 5.6±4.3, and 4.9±4.9 mm in entire cohort (n=100); 5.6±2.6, 6.0±3.5, 6.7±5.8, 6.7±5.7, and 6.1±7.4 mm in group A (n=38); 4.9±3.1, 4.8±3.0, 5.0±3.5, 5.0±2.9, and 4.3±2.8 mm in group B (n=62), respectively. The 3D displacements of group A were longer than those of group B, but only significant difference was observed in lateral clip (p=0.047).
Conclusion
This study demonstrated displacement of surgical clips during whole breast irradiation in patients with ADM insertion. For patients who had breast volume replacement using ADM, adaptive boost planning should be considered. -
Citations
Citations to this article as recorded by- Interobserver variability of clinical target volume delineation in patients undergoing breast-conserving surgery without surgical clips: a pilot study on preoperative magnetic resonance simulation
Shuning Jiao, Yiqing Wang, Jiabin Ma, Jing Shen, Xi-Qian Zhang, Bing Zhou, Xiansong Sun, Haoran Xu, Xia Liu, Ke Hu, Fuquan Zhang, Xiaorong Hou, Jie Qiu
BMC Cancer.2024;[Epub] CrossRef - What Should We Know in Postoperative Surveillance Imaging After Oncoplastic Breast-Conserving Surgery with Pellet-Type Acellular Dermal Matrix?
Yeong Yi An, Hyejung Hwang, Young Jin Suh
Academic Radiology.2023; 30: S16. CrossRef - Imaging surveillance for the detection of ipsilateral local tumor recurrence in patients who underwent oncoplastic breast-conserving surgery with acellular dermal matrix: abbreviated MRI versus conventional mammography and ultrasonography
Mi Young Kim, Young Jin Suh, Yeong Yi An
World Journal of Surgical Oncology.2021;[Epub] CrossRef
- Interobserver variability of clinical target volume delineation in patients undergoing breast-conserving surgery without surgical clips: a pilot study on preoperative magnetic resonance simulation
- 6,056 View
- 175 Download
- 3 Web of Science
- 3 Crossref
- Type-Specific Viral Load and Physical State of HPV Type 16, 18, and 58 as Diagnostic Biomarkers for High-Grade Squamous Intraepithelial Lesions or Cervical Cancer
- Jongseung Kim, Bu Kyung Kim, Dongsoo Jeon, Chae Hyeong Lee, Ju-Won Roh, Joo-Young Kim, Sang-Yoon Park
- Cancer Res Treat. 2020;52(2):396-405. Published online August 28, 2019
- DOI: https://doi.org/10.4143/crt.2019.152
-
Abstract
PDF
Supplementary MaterialPubReaderePub - Purpose
High rate of false-positive tests is a major obstacle to use human papillomavirus (HPV) detection as a diagnostic tool for high-grade squamous intraepithelial lesions or cervical cancer (HSIL+). We investigated whether type-specific viral load or physical state of HPV 16, 18, and 58 are useful biomarkers for HSIL+.
Materials and Methods
Type-specific viral loads of E6 and E2 genes in cervical cells from 240, 83, and 79 HPV 16–, 18–, and 58–infected women, respectively, were determined using real-time polymerase chain reaction. Viral loads were normalized to cellular DNA (copy/cell). Total and integrated viral loads and physical state were compared between HSIL+ and controls, and diagnostic value was determined using receiver operating characteristic analysis.
Results
Viral loads of HPV 16, 18, and 58 were significantly different in lesions in the same pathologic grade. High type-specific total viral loads were significantly associated with HSIL+ (odds ratio [OR], 14.065, 39.472, and 7.103 for HPV 16, 18, and 58, respectively). High integrated viral load was related to HSIL+ in women with HPV 16 (OR, 8.242), and integrated state was associated with HSIL+ in women with HPV 18 (OR, 9.443). Type-specific total viral load was significantly associated with HSIL+ (area under curve, 0.914, 0.937, and 0.971 for HPV 16, 18, and 58, respectively), indicating an excellent performance in detecting HSIL+.
Conclusion
Type-specific total viral load may be a powerful diagnostic marker for HSIL+ in HPV 16–, 18–, and 58–infected HSIL+ lesions. If demonstrated in all other high-risk HPV types, this method can lead to a paradigm shift in the strategy of equivocal cytologic abnormalities. -
Citations
Citations to this article as recorded by- Correlation of different HPV genotype viral loads and cervical lesions: A retrospective analysis of 1585 cases
Yilu Zhou, Jiaxin Liu, Shuai Chen, Xianzhen Xin, Mohan Xiao, Xian Qiang, Lina Zhang
Cancer Cytopathology.2025;[Epub] CrossRef - Analysis of HPV-16 viral load, integration status, and p16 expression in relation to EBV co-infection and cervical lesion severity
Azam Khamseh, Ali Farhadi, Somayeh Jalilvand, Fariba Yarandi, Narges Izadi-Mood, Saied Ghorbani, Hassan Saadati, Elham Shirali, Seyed Mohammad Jazayeri, Jamal Sarvari
Scientific Reports.2025;[Epub] CrossRef - Progress in the Study of Cervical Cancer Screening Methods
祺 孙
Advances in Clinical Medicine.2025; 15(03): 1989. CrossRef - Electrochemical Duplex Detection of E2 and E6 Genes of Human Papillomavirus Type 16 and Determination of Physical Status in High‐Risk Cervical Carcinoma
Sinthu Karunaithas, Thanyarat Chaibun, Patutong Chatchawal, Chamras Promptmas, Waranun Buajeeb, Lee Su Yin, Patcharee Jearanaikoon, Benchaporn Lertanantawong
Journal of Medical Virology.2025;[Epub] CrossRef - HPV vaccination status and effectiveness in Korean women with HPV16/18 infection (2010–2021): a retrospective study
Yoo Jin Na, Oeuk Jeong, Jaehyun Seong, JeongGyu Lee, So Young Lee, Sooyoung Hur, Sangmi Ryou
Journal of Gynecologic Oncology.2024;[Epub] CrossRef - Evaluation of human papillomavirus type 16 viral load and genome physical status in Iranian women with cervical disease
Shadi Setayeshi, Ali Hasanzadeh, Yousef Yahyapour, Ahad Alizadeh, Hossein Ghorbani, Fahimeh Nokhostin, Meghdad Bagheri, Farzin Sadeghi
Molecular Biology Reports.2024;[Epub] CrossRef - Biomarkers in the Screening and Management of Cervical Cancer
Pallavi Punhani, Charanjeet Ahluwalia
Journal of Colposcopy and Lower Genital Tract Pathology.2024; 2(1): 6. CrossRef - Prevalence of Carcinogenic Genotypes of HPV-Infected Women in a Ten-Year Period (2014–2023) in Vojvodina, Serbia
Natasa Nikolic, Branka Basica, Mirjana Strbac, Lidija Terzic, Aleksandra Patic, Gordana Kovacevic, Radmila Velicki, Dusan Petrovic, Aljosa Mandic, Vladimir Petrovic
Medicina.2024; 60(6): 922. CrossRef - Increased human papillomavirus viral load is correlated to higher severity of cervical disease and poorer clinical outcome: A systematic review
Seth‐Frerich Fobian, Xionge Mei, Johannes Crezee, Barbara C. Snoek, Renske D. M. Steenbergen, Jiafen Hu, Timo L. M. ten Hagen, Louis Vermeulen, Lukas J. A. Stalpers, Arlene L. Oei
Journal of Medical Virology.2024;[Epub] CrossRef - The Diagnostic Significance of Combined Screening and Human Papillomavirus 16 and 18 Cycle Threshold Values for CIN2+ Cervical Lesions
Xue Bai, Ya-Kun Liu, Ya-Jing Jia, Dao-Juan Li, Nai-Yi Du
International Journal of Women's Health.2024; Volume 16: 1959. CrossRef - Evaluation of Human Papilloma Virus (HPV) Genotyping and Viral Load Determination as Diagnostic Biomarkers of Cervical Cancer Risk
Marianna Martinelli, Chiara Giubbi, Laura Saderi, Rosario Musumeci, Federica Perdoni, Biagio Eugenio Leone, Robert Fruscio, Fabio Landoni, Andrea Piana, Giovanni Sotgiu, Clementina Elvezia Cocuzza
International Journal of Molecular Sciences.2023; 24(2): 1320. CrossRef - Implications of viral infections and oncogenesis in uterine cervical carcinoma etiology and pathogenesis
Daming Chu, Tengteng Liu, Yuan Yao
Frontiers in Microbiology.2023;[Epub] CrossRef - Prevalence and Risk Factors for High-Risk Human Papillomavirus Infection and Cervical Disorders: Baseline Findings From an Human Papillomavirus Cohort Study
Paula Saldaña-Rodríguez, Margarita Bahena-Román, Karina Delgado-Romero, Vicente Madrid-Marina, Kirvis Torres-Poveda
Cancer Control.2023;[Epub] CrossRef - A Review of the Application of Heterostructure Catalysts in Hydrogen Evolution Reaction
Shizhi Dong, Yanshuai Li, Zhilong Zhao, Ruichuan Li, Jiaqi He, Jinpeng Yin, Bing Yan, Xing Zhang
ChemistrySelect.2022;[Epub] CrossRef - The frequency of infection with high-risk human papilloma virus types on the cervix uteri of women of reproductive age
Jovana Prelić, Aleksandra Knežević
Medicinski podmladak.2022; 73(1): 55. CrossRef - Influence of Lacidophilin Vaginal Capsules plus rh-IFN-α2b on Efficacy, Vaginal Microecology, and Safety of Patients with HPV Infection
Yan Sun, Jianqun Xu, Hongya Zhou, Lina You, Yan Zhu, Shoib Baba
Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1. CrossRef - Comparison of cycle threshold values of the Cobas HPV test and viral loads of the BMRT HPV test in cervical cancer screening
Qing Yang, Hui Du, Xinfeng Qu, Wenkui Dai, Liming Gui, Changzhong Li, Chun Wang, Chunlei Guo, Yi Zhang, Lihui Wei, J. L. Belinson, Ruifang Wu
Frontiers in Public Health.2022;[Epub] CrossRef - EGFR Protein Expression Relates with Tumor Histology, Methylation Status of EGFR and HPV16 E6 Viral Load in Oropharyngeal Carcinoma
Yo Suzuki, Yuki Fukumura, Miki Asahina, Mitsuhisa Fujimaki, Shinichi Ohba, Fumihiko Matsumoto, Isao Kurahayashi, Takashi Yao, Katsuhisa Ikeda
Head and Neck Pathology.2021; 15(3): 743. CrossRef - Detection of 14 High-Risk Human Papillomaviruses Using Digital LAMP Assays on a Self-Digitization Chip
Jiasi Wang, Jeannette P. Staheli, Andrew Wu, Jason E. Kreutz, Qiongzheng Hu, Jingang Wang, Thomas Schneider, Bryant S. Fujimoto, Yuling Qin, Gloria S. Yen, Bob Weng, Kara Shibley, Halia Haynes, Rachel L. Winer, Qinghua Feng, Daniel T. Chiu
Analytical Chemistry.2021; 93(6): 3266. CrossRef - Viral load and high prevalence of HR-HPV52 and 58 types in black women from rural communities
Lays Paula Bondi Volpini, Jerusa Araújo Dias, Luciana Bueno de Freitas, Maria Carmen Lopes Ferreira Silva, Angélica Espinosa Miranda, Liliana Cruz Spano
BMC Infectious Diseases.2021;[Epub] CrossRef - Significance of HPV16 Viral Load Testing in Anal Cancer
Ewa Małusecka, Ewa Chmielik, Rafał Suwiński, Monika Giglok, Dariusz Lange, Tomasz Rutkowski, Agnieszka M. Mazurek
Pathology & Oncology Research.2020; 26(4): 2191. CrossRef - Cervical cancer risk profiling: molecular biomarkers predicting the outcome of hrHPV infection
Mariano A Molina, Ludovica Carosi Diatricch, Marina Castany Quintana, Willem JG Melchers, Karolina M Andralojc
Expert Review of Molecular Diagnostics.2020; 20(11): 1099. CrossRef - MicroRNA-Based Fingerprinting of Cervical Lesions and Cancer
Justyna Pisarska, Katarzyna Baldy-Chudzik
Journal of Clinical Medicine.2020; 9(11): 3668. CrossRef
- Correlation of different HPV genotype viral loads and cervical lesions: A retrospective analysis of 1585 cases
- 10,689 View
- 311 Download
- 20 Web of Science
- 23 Crossref
- Apatinib Combined with Local Irradiation Leads to Systemic Tumor Control via Reversal of Immunosuppressive Tumor Microenvironment in Lung Cancer
- Li-jun Liang, Chen-xi Hu, Yi-xuan Wen, Xiao-wei Geng, Ting Chen, Guo-qing Gu, Lei Wang, You-you Xia, Yong Liu, Jia-yan Fei, Jie Dong, Feng-hua Zhao, Yiliyar Ahongjiang, Kai-yuan Hui, Xiao-dong Jiang
- Cancer Res Treat. 2020;52(2):406-418. Published online September 3, 2019
- DOI: https://doi.org/10.4143/crt.2019.296
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
This study aimed to investigate the potential systemic antitumor effects of stereotactic ablative radiotherapy (SABR) and apatinib (a novel vascular endothelial growth factor receptor 2 inhibitor) via reversing the immunosuppressive tumor microenvironment for lung carcinoma.
Materials and Methods
Lewis lung cancer cells were injected into C57BL/6 mice in the left hindlimb (primary tumor; irradiated) and in the right flank (secondary tumor; nonirradiated). When both tumors grew to the touchable size, mice were randomly divided into eight treatment groups. These groups received normal saline or three distinct doses of apatinib (50 mg/kg, 150 mg/kg, and 200 mg/kg) daily for 7 days, in combination with a single dose of 15 Gy radiotherapy or not to the primary tumor. The further tumor growth/regression of mice were followed and observed.
Results
For the single 15 Gy modality, tumor growth delay could only be observed at the primary tumor. When combining SABR and apatinib 200 mg/kg, significant retardation of both primary and secondary tumor growth could be observed, indicated an abscopal effect was induced. Mechanism analysis suggested that programmed death-ligand 1 expression increased with SABR was counteract by additional apatinib therapy. Furthermore, when apatinib was combined with SABR, the composition of immune cells could be changed. More importantly, this two-pronged approach evoked tumor antigen–specific immune responses and the mice were resistant to another tumor rechallenge, finally, long-term survival was improved.
Conclusion
Our results suggested that the tumor microenvironment could be managed with apatinib, which was effective in eliciting an abscopal effect induced by SABR. -
Citations
Citations to this article as recorded by- Antiangiogenic Treatment Facilitates the Abscopal Effect of Radiation Therapy Combined With Anti-PD-1 in Hepatocellular Carcinoma
Hailong Sheng, Yongyi Luo, Liting Zhong, Zhiyi Wang, Zhichao Sun, Xinna Gao, Xinrong He, Zhenru Zhu, Dehua Wu, Jingyuan Sun, Chuanhui Cao
International Journal of Radiation Oncology*Biology*Physics.2025; 121(2): 534. CrossRef - Interactions between radiotherapy resistance mechanisms and the tumor microenvironment
Dengxiong Li, Jie Wang, Xinrui Li, Zhipeng Wang, Qingxin Yu, Siang Boon Koh, Ruicheng Wu, Luxia Ye, Yiqing Guo, Uzoamaka Okoli, Alisha Pati-Alam, Eduardo Mota, Wuran Wei, Koo Han Yoo, William C. Cho, Dechao Feng, Susan Heavey
Critical Reviews in Oncology/Hematology.2025; 210: 104705. CrossRef - Combination of potassium oxonate with anti-PD-1 for the treatment of colorectal cancer
Yuanyuan Wang, Chenxi Hu, Tianpeng Du, Jiawen Li, Kaiyuan Hui, Xiaodong Jiang
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K. Shao, Y. Hao, M. Xu, Z. Shi, G. Lin, C. Xu, Y. Zhang, Z. Song
Clinical Oncology.2024; 36(11): 710. CrossRef - Immune effect and prognosis of transcatheter arterial chemoembolization and tyrosine kinase inhibitors therapy in patients with hepatocellular carcinoma
Yuan Guo, Ru-Chun Li, Wei-Li Xia, Xiong Yang, Wen-Bo Zhu, Fang-Ting Li, Hong-Tao Hu, Hai-Liang Li
World Journal of Gastrointestinal Oncology.2024; 16(7): 3256. CrossRef - A disintegrin and metalloproteinase domain 10 expression inhibition by the small molecules adenosine, cordycepin and N6, N6-dimethyladenosine and immune regulation in malignant cancers
Wenqian Zhang, Jiewen Fu, Jiaman Du, Xiaoyan Liu, Jingliang Cheng, Chunli Wei, Youhua Xu, Junjiang Fu
Frontiers in Immunology.2024;[Epub] CrossRef - Low‐ dose Apatinib promotes vascular normalization and hypoxia reduction and sensitizes radiotherapy in lung cancer
Shanshan Jiang, Yue Zhou, Liqing Zou, Li Chu, Xiao Chu, Jianjiao Ni, Yida Li, Tiantian Guo, Xi Yang, Zhengfei Zhu
Cancer Medicine.2023; 12(4): 4434. CrossRef - Local Destruction of Tumors and Systemic Immune Effects
Karl-Göran Tranberg
Frontiers in Oncology.2021;[Epub] CrossRef - A novel role for apatinib in enhancing radiosensitivity in non-small cell lung cancer cells by suppressing the AKT and ERK pathways
Lin Li, Yuexian Li, Huawei Zou
PeerJ.2021; 9: e12356. CrossRef
- Antiangiogenic Treatment Facilitates the Abscopal Effect of Radiation Therapy Combined With Anti-PD-1 in Hepatocellular Carcinoma
- 9,964 View
- 362 Download
- 10 Web of Science
- 9 Crossref
- Changes of End of Life Practices for Cancer Patients and Their Association with Hospice Palliative Care Referral over 2009-2014: A Single Institution Study
- Hyun Jung Jho, Eun Jung Nam, Il Won Shin, Sun Young Kim
- Cancer Res Treat. 2020;52(2):419-425. Published online September 3, 2019
- DOI: https://doi.org/10.4143/crt.2018.648
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Abstract
PDFPubReaderePub
- Purpose
In Korea, hospice palliative care (HPC) provision for cancer patients has increased recently. However, whether end of life (EoL) care practices have improved along with the development of HPC is unclear. We intended to investigate the changes in EoL care practices and their association with HPC referral. Materials and Methods Retrospective medical record review of adult cancer patients who died at National Cancer Center Korea from 1 January 2009 to 31 December 2014 was performed. Changes of EoL practices including chemotherapy within 2 weeks from death, death in intensive care unit (ICU), documentation of “do not resuscitate (DNR)” within 7 days from death and referral to HPC from 2009 to 2014 were analyzed as well as the association between referral to HPC and other practices.
Results
A total of 2,377 cases were included in the analysis. Between 2009 and 2014, referral to HPC increased and DNR documentation within 7 days from death decreased significantly. Cases for chemotherapy within 2 weeks from death and death in ICU didn’t change over the study period. Patients referred to HPC were less likely to receive chemotherapy within 2 weeks from death, die in ICU and document DNR within 7 days from death. Conclusion During the study period, EoL practices among cancer patients partly changed toward less aggressive in our institution. HPC referral was associated with less aggressive cancer care at the EoL. Policies to promote EoL discussion are necessary to improve the EoL practices of cancer patients. -
Citations
Citations to this article as recorded by- Decreased aggressive care at the end of life among advanced cancer patients in the Republic of Korea: a nationwide study from 2012 to 2018
Sara Kwon, Kyuwoong Kim, Bohyun Park, So-Jung Park, Hyun Jung Jho, Jin Young Choi
BMC Palliative Care.2024;[Epub] CrossRef - Symptom burden, palliative care knowledge, and palliative care needs in advanced gynecological cancer patients in Korea
Eungil Ko, Yaelim Lee
Supportive Care in Cancer.2024;[Epub] CrossRef - End-of-Life Decision Making in Patients with Advanced Dementia: The Perspectives of the Korean General Population and Clinicians
So Yeon Jeon, Shin Hye Yoo, Jung Lee, In Gyu Song, Min Sun Kim, Hye Yoon Park
Psychiatry Investigation.2024; 21(10): 1137. CrossRef - Advance Care Planning in South Korea
Yu Jung Kim, Sun-Hyun Kim
Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen.2023; 180: 68. CrossRef - Public awareness of advance care planning and hospice palliative care: a nationwide cross-sectional study in Korea
Boram Kim, Junyong Lee, Youn Seon Choi
BMC Palliative Care.2023;[Epub] CrossRef - Prevalence and related factors of do-not-resuscitate orders among in-hospital cardiac arrest patients
Tangxing Jiang, Yanyan Ma, Jiaqi Zheng, Chunyi Wang, Kai Cheng, Chuanbao Li, Feng Xu, Yuguo Chen
Heart & Lung.2022; 51: 9. CrossRef - Discussing POLST-facilitated hospice care enrollment in patients with terminal cancer
Ho Jung An, Hyun Jeong Jeon, Sang Hoon Chun, Hyun Ae Jung, Hee Kyung Ahn, Kyung Hee Lee, Min-ho Kim, Ju Hee Kim, Jaekyung Cheon, Su-Jin Koh
Supportive Care in Cancer.2022; 30(9): 7431. CrossRef - A National Study of Life-Sustaining Treatments in South Korea: What Factors Affect Decision-Making?
So-Youn Park, Bomyee Lee, Jeong Yeon Seon, In-Hwan Oh
Cancer Research and Treatment.2021; 53(2): 593. CrossRef - Difficulties Doctors Experience during Life-Sustaining Treatment Discussion after Enactment of the Life-Sustaining Treatment Decisions Act: A Cross-Sectional Study
Shin Hye Yoo, Wonho Choi, Yejin Kim, Min Sun Kim, Hye Yoon Park, Bhumsuk Keam, Dae Seog Heo
Cancer Research and Treatment.2021; 53(2): 584. CrossRef - Changes in decision-making process for life-sustaining treatment in patients with advanced cancer after the life-sustaining treatment decisions-making act
Hyeyeong Kim, Hyeon-Su Im, Kyong Og Lee, Young Joo Min, Jae-Cheol Jo, Yunsuk Choi, Yoo Jin Lee, Daseul Kang, Changyoung Kim, Su-Jin Koh, Jaekyung Cheon
BMC Palliative Care.2021;[Epub] CrossRef - Consent for withholding life-sustaining treatment in cancer patients: a retrospective comparative analysis before and after the enforcement of the Life Extension Medical Decision law
Yu Jin Chung, Incheol Park, Junho Cho, Jin Ho Beom, Ji Eun Lee
BMC Medical Ethics.2021;[Epub] CrossRef - Implication of the Life-Sustaining Treatment Decisions Act on End-of-Life Care for Korean Terminal Patients
Jung Sun Kim, Shin Hye Yoo, Wonho Choi, Yejin Kim, Jinui Hong, Min Sun Kim, Hye Yoon Park, Bhumsuk Keam, Dae Seog Heo
Cancer Research and Treatment.2020; 52(3): 917. CrossRef
- Decreased aggressive care at the end of life among advanced cancer patients in the Republic of Korea: a nationwide study from 2012 to 2018
- 6,526 View
- 177 Download
- 13 Web of Science
- 12 Crossref
- Outcomes of Pregnancy after Breast Cancer in Korean Women: A Large Cohort Study
- Moo Hyun Lee, Young Ae Kim, Jin Hyuk Hong, So-Youn Jung, Sunmi Lee, Sun-Young Kong, Boyoung Park, Eun Sook Lee
- Cancer Res Treat. 2020;52(2):426-437. Published online September 3, 2019
- DOI: https://doi.org/10.4143/crt.2018.382
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Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
The purpose of this study was to determine the rate and outcomes of pregnancies subsequent to breast cancer in Korea, and the effect of such pregnancies on the prognosis of women who survived breast cancer and subsequently conceived. Materials and Methods We followed a total of 31,761 Korean women 45 years of age or younger who were treated for primary breast cancer from 2002 to 2010. We also included follow-up surveys that were conducted through December 2011. We identified recurrence and mortality from breast cancer using data linked to the Korea National Health Insurance database. We used propensity score matching of the study cohort to analyze the risks of recurrence and mortality from breast cancer depending on pregnancy.
Results
Within our sample, 992 women (3.1%) became pregnant after receiving treatment for breast cancer. Of those, 622 (67.5%) successfully delivered; the remaining 370 (32.5%) failed to deliver. After propensity score matching, we found that the women who became pregnant after breast cancer did not have a different risk of recurrence (hazard ratio [HR], 0.503; 95% confidence interval [CI], 0.434 to 0.584) and death (HR, 0.520; 95% CI, 0.397 to 0.681), compared with those who did not conceive after breast cancer treatment. Conclusion Our study is the first to report outcomes for Korean women who survived breast cancer and subsequently conceived. Women who survived breast cancer and subsequently became pregnant did not show a poorer survival outcome, compared with those who did not become pregnant. -
Citations
Citations to this article as recorded by- Reproduction outcomes and prognostic significance of pregnancy after nasopharyngeal carcinoma treatment
Meijuan Luo, Liting Liu, Zhenchong Yang, Yujing Liang, Dongxiang Wen, Sailan Liu, Xiaoyun Li, Chuanmiao Xie, Linquan Tang, Qiuyan Chen, Shanshan Guo, Haiqiang Mai
Annals of Medicine.2025;[Epub] CrossRef - Conception and pregnancy among women with a live birth after breast cancer treatment: A survey study of young breast cancer survivors
Kimia Sorouri, Tal Sella, Shoshana M. Rosenberg, Maggie Loucks, Gregory Kirkner, Craig Snow, Kathryn J. Ruddy, Shari I. Gelber, Rulla M. Tamimi, Jeffrey M. Peppercorn, Lidia Schapira, Virginia F. Borges, Steven E. Come, Ellen Warner, Ann H. Partridge
Cancer.2024; 130(4): 517. CrossRef - Safe and successful pregnancy following breast cancer treatment in young patients 35 years old or under without invasive fertility preservation: a retrospective study
Ji Hye Kim, Yong Yeup Kim, Jai Hyun Chung, Woo Young Kim, Jae Bok Lee, Sang Uk Woo
Annals of Surgical Treatment and Research.2024; 106(4): 189. CrossRef - Female reproductive health in pediatric, adolescent, and young adult cancer survivors
Holly R. Hoefgen, Janie Benoit, Serena Chan, Yasmin Jayasinghe, Maryam Lustberg, Victoria Pohl, Amanda Saraf, Deb Schmidt, Leslie Coker Appiah
Pediatric Blood & Cancer.2023;[Epub] CrossRef - Pregnancy rate, maternal and neonatal outcomes among breast cancer survivors: A systematic review
Marzieh Azizi, Elham Ebrahimi, Zahra Behboodi Moghadam, Zohreh Shahhosseini, Maryam Modarres
Nursing Open.2023; 10(10): 6690. CrossRef - Breast Cancer in Pregnancy
Natalie Levey, Iris Krishna
Obstetrics and Gynecology Clinics of North America.2022; 49(1): 181. CrossRef - Prognosis of pregnancy after breast cancer diagnosis according to the type of treatment: A population-based study in Korea by the SMARTSHIP group
Soo Youn Bae, Jihyoun Lee, Ji Sung Lee, Jae Sun Yoon, Ku Sang Kim, Yoo Seok Kim, Zisun Kim, Jun Won Min, Eun-Jung Shim, Ilkyun Lee, Min Hyuk Lee, Sungmin Park
The Breast.2022; 63: 46. CrossRef - Update on Pregnancy Following Breast Cancer Diagnosis and Treatment
Marta Perachino, Francesca Poggio, Luca Arecco, Eva Blondeaux, Stefano Spinaci, Camilla Marrocco, Alessia Levaggi, Matteo Lambertini
The Cancer Journal.2022; 28(3): 176. CrossRef - Survival outcomes following pregnancy or assisted reproductive technologies after breast cancer: A population‐based study
J. Alejandro Rauh‐Hain, Jose Zubizarreta, Roni Nitecki, Alexander Melamed, Shuangshuang Fu, Kirsten Jorgensen, Paula C. Brady, Valerie L. Baker, Mariana Chavez‐MacGregor, Sharon H. Giordano, Nancy L. Keating
Cancer.2022; 128(17): 3243. CrossRef - Survival after breast cancer in women with a subsequent live birth: Influence of age at diagnosis and interval to subsequent pregnancy
Richard A. Anderson, Matteo Lambertini, Peter S. Hall, W. Hamish Wallace, David S. Morrison, Tom W. Kelsey
European Journal of Cancer.2022; 173: 113. CrossRef - Pregnancy After Breast Cancer: A Systematic Review and Meta-Analysis
Matteo Lambertini, Eva Blondeaux, Marco Bruzzone, Marta Perachino, Richard A. Anderson, Evandro de Azambuja, Philip D. Poorvu, Hee Jeong Kim, Cynthia Villarreal-Garza, Barbara Pistilli, Ines Vaz-Luis, Cristina Saura, Kathryn J. Ruddy, Maria Alice Franzoi,
Journal of Clinical Oncology.2021; 39(29): 3293. CrossRef
- Reproduction outcomes and prognostic significance of pregnancy after nasopharyngeal carcinoma treatment
- 7,801 View
- 337 Download
- 11 Web of Science
- 11 Crossref
- Loss of Heterozygosity at Chromosome 16q Is a Negative Prognostic Factor in Korean Pediatric Patients with Favorable Histology Wilms Tumor: A Report of the Korean Pediatric Hematology Oncology Group (K-PHOG)
- Jun Eun Park, O Kyu Noh, Yonghee Lee, Hyoung Soo Choi, Jung Woo Han, Seung Min Hahn, Chuhl Joo Lyu, Ji Won Lee, Keon Hee Yoo, Hong Hoe Koo, Seon-Yong Jeong, Ki Woong Sung
- Cancer Res Treat. 2020;52(2):438-445. Published online September 10, 2019
- DOI: https://doi.org/10.4143/crt.2019.313
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Abstract
PDFPubReaderePub
- Purpose
Loss of heterozygosity (LOH) at chromosomes 1p and 16q is a poor prognostic factor in favorable histology Wilms tumor (FHWT). This study investigated the prevalence of LOH at 1p and 16q and evaluated its prognostic value in Korean children with FHWT. Materials and Methods We analyzed 101 FHWT patients who were diagnosed between 1996 and 2016 in Korean Society of Pediatric Hematology Oncology Group hospitals. Using paraffin-embedded kidney tissue samples sent from each center, we reviewed LOH at 1p and 16q in each patient and assessed the prognostic value of LOH status for clinical parameters affecting event-free survival (EFS).
Results
Of the 101 patients, 12 (11.9%) experienced recurrence; the 3-year EFS was 87.6%. LOH at 1p or 16q was detected in 19 patients (18.8%), with five having LOH at both 1q and 16q. The frequency of LOH at 1p was higher among younger patients (p=0.049), but there was no difference in LOH prevalence according to tumor stage. In the multivariate analysis, LOH at 16q was a significant negative prognostic factor affecting EFS (3-year EFS, 73.7% vs. 91.1%; hazard ratio, 3.95; p=0.037), whereas LOH at 1p was not (p=0.786). Conclusion LOH at 16q was a significant negative prognostic factor affecting outcome in Korean pediatric FHWT patients. Due to the small sample size of this study, large-scale multicenter trials are warranted to investigate the prognostic value of LOH at 1p and 16q in Korean children with FHWT. -
Citations
Citations to this article as recorded by- Loss of heterozygosity for chromosomes 16q in Wilms tumors predicts outcomes: A meta-analysis
Yuan-Hua Song, Wen-Ling Li, Zhen Yang, Yan Gao, Zhi-Ping Feng
World Journal of Gastrointestinal Oncology.2024; 16(5): 2159. CrossRef - Inter-Ethnic Variations in the Clinical, Pathological, and Molecular Characteristics of Wilms Tumor
Kia Teng Lim, Amos H. P. Loh
Cancers.2024; 16(17): 3051. CrossRef - Characterization of malignant kidney tumors in childhood by 18F-FDG PET/CT
Jinyu Gou, Xueli Ji, Shuqi Wu, Hui Wang, Suyun Chen
World Journal of Urology.2024;[Epub] CrossRef - Epidemiologic and Clinical Outcomes of Pediatric Renal Tumors in Korea: A Retrospective Analysis of The Korean Pediatric Hematology and Oncology Group (KPHOG) Data
Kyung-Nam Koh, Jung Woo Han, Hyoung Soo Choi, Hyoung Jin Kang, Ji Won Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo, Kyung Taek Hong, Jung Yoon Choi, Sung Han Kang, Hyery Kim, Ho Joon Im, Seung Min Hahn, Chuhl Joo Lyu, Hee-Jo Baek, Hoon Kook, Kyung Mi Pa
Cancer Research and Treatment.2023; 55(1): 279. CrossRef - Research Advances of Prognostic Risk Factors of Wilms Tumor
建宇 汪
World Journal of Cancer Research.2023; 13(02): 51. CrossRef - Current Challenges of Asian National Children's Cancer Study Groups on Behalf of Asian Pediatric Hematology and Oncology Group
Chi-kong Li, Purna Kurkure, Ramandeep Singh Arora, Bow Wen Chen, Kirill Kirgizov, Yasuhiro Okamoto, Panya Seksarn, Yongmin Tang, Keon Hee Yoo, Bharat Agarwal, Godfrey C.F. Chan, Rashmi Dalvi, Hiroki Hori, Muhammad Saghir Khan, Alice Yu, Akira Nakagawara
JCO Global Oncology.2023;[Epub] CrossRef
- Loss of heterozygosity for chromosomes 16q in Wilms tumors predicts outcomes: A meta-analysis
- 6,753 View
- 252 Download
- 5 Web of Science
- 6 Crossref
- Carcinoembryonic Antigen Improves the Performance of Magnetic Resonance Imaging in the Prediction of Pathologic Response after Neoadjuvant Chemoradiation for Patients with Rectal Cancer
- Gyu Sang Yoo, Hee Chul Park, Jeong Il Yu, Doo Ho Choi, Won Kyung Cho, Young Suk Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Woo Yong Lee, Hee Cheol Kim, Seong Hyeon Yun, Yong Beom Cho, Yoon Ah Park, Kyoung Doo Song, Seok-Hyung Kim, Sang Yun Ha
- Cancer Res Treat. 2020;52(2):446-454. Published online September 25, 2019
- DOI: https://doi.org/10.4143/crt.2019.261
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Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
The purpose of this study was to investigate the role of carcinoembryonic antigen (CEA) levels in improving the performance of magnetic resonance imaging (MRI) for the prediction of pathologic response after the neoadjuvant chemoradiation (NCRT) for patients with rectal cancer.
Materials and Methods
We retrospectively reviewed the medical records of 524 rectal cancer patients who underwent NCRT and total mesorectal excision between January 2009 and December 2014. The performances of MRI with or without CEA parameters (initial CEA and CEA dynamics) for prediction of pathologic tumor response grade (pTRG) were compared by receiver-operating characteristic analysis with DeLong’s method. Cox regression was used to identify the independent factors associated to pTRG and disease-free survival (DFS) after NCRT.
Results
The median follow-up was 64.0 months (range, 3.0 to 113.0 months). On multivariate analysis, poor tumor regression grade on MRI (mrTRG; p < 0.001), initial CEA (p < 0.001) and the mesorectal fascia involvement on MRI before NCRT (mrMFI; p=0.054) showed association with poor pTRG. The mrTRG plus CEA parameters showed significantly improved performances in the prediction of pTRG than mrTRG alone. All of mrTRG, mrMFI, and initial CEA were also identified as independent factors associated with DFS. The initial CEA further discriminated DFS in the subgroups with good mrTRG or that without mrMFI.
Conclusion
The CEA parameters significantly improved the performance of MRI in the prediction of pTRG after NCRT for patients with rectal cancer. The DFS was further discriminated by initial CEA level in the groups with favorable MRI parameters. -
Citations
Citations to this article as recorded by- Clinical outcomes of neoadjuvant chemoradiotherapy followed by total mesorectal excision in locally advanced rectal cancer with mesorectal fascia involvement
Jeong Ha Lee, Nalee Kim, Jeong Il Yu, Gyu Sang Yoo, Hee Chul Park, Woo-Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Yong Beom Cho, Jung Wook Huh, Yoon Ah Park, Jung Kyong Shin, Joon Oh Park, Seung Tae Kim, Young Suk Park, Jeeyun Lee, Won Ki Kang
Radiation Oncology Journal.2024; 42(2): 130. CrossRef - Predicting the response to neoadjuvant chemoradiation for rectal cancer using nomograms based on MRI tumour regression grade
S. Qin, Y. Chen, K. Liu, Y. Li, Y. Zhou, W. Zhao, P. Xin, Q. Wang, S. Lu, H. Wang, N. Lang
Cancer/Radiothérapie.2024; 28(4): 341. CrossRef - Body composition parameters combined with blood biomarkers and magnetic resonance imaging predict responses to neoadjuvant chemoradiotherapy in locally advanced rectal cancer
Jianguo Yang, Qican Deng, Zhenzhou Chen, Yajun Chen, Zhongxue Fu
Frontiers in Oncology.2023;[Epub] CrossRef - Pretreatment blood biomarkers combined with magnetic resonance imaging predict responses to neoadjuvant chemoradiotherapy in locally advanced rectal cancer
Xinyu Shi, Min Zhao, Bo Shi, Guoliang Chen, Huihui Yao, Junjie Chen, Daiwei Wan, Wen Gu, Songbing He
Frontiers in Oncology.2022;[Epub] CrossRef - Clinical implication and management of rectal cancer with clinically suspicious lateral pelvic lymph node metastasis: A radiation oncologist’s perspective
Gyu Sang Yoo, Hee Chul Park, Jeong Il Yu
Frontiers in Oncology.2022;[Epub] CrossRef - High-Resolution T2-Weighted MRI to Evaluate Rectal Cancer: Why Variations Matter
Kirsten L Gormly
Korean Journal of Radiology.2021; 22(9): 1475. CrossRef - MRI Assessment of Complete Response to Preoperative Chemoradiation Therapy for Rectal Cancer: 2020 Guide for Practice from the Korean Society of Abdominal Radiology
Seong Ho Park, Seung Hyun Cho, Sang Hyun Choi, Jong Keon Jang, Min Ju Kim, Seung Ho Kim, Joon Seok Lim, Sung Kyoung Moon, Ji Hoon Park, Nieun Seo
Korean Journal of Radiology.2020; 21(7): 812. CrossRef
- Clinical outcomes of neoadjuvant chemoradiotherapy followed by total mesorectal excision in locally advanced rectal cancer with mesorectal fascia involvement
- 7,249 View
- 183 Download
- 7 Web of Science
- 7 Crossref
- Validation of the 8th Edition of the American Joint Committee on Cancer Staging System for Gallbladder Cancer and Implications for the Follow-up of Patients without Node Dissection
- You-Na Sung, Minjeong Song, Jae Hoon Lee, Ki Byung Song, Dae Wook Hwang, Chul-Soo Ahn, Shin Hwang, Seung-Mo Hong
- Cancer Res Treat. 2020;52(2):455-468. Published online October 17, 2019
- DOI: https://doi.org/10.4143/crt.2019.271
-
Abstract
PDFPubReaderePub
- Purpose
The 8th edition of gallbladder cancer staging in the American Joint Committee on Cancer (AJCC) staging system changed the T and N categories.
Materials and Methods
In order to validate the new staging system, a total of 348 surgically resected gallbladder cancers were grouped based on the 8th edition of the T and N categories and compared with patients’ survival.
Results
Significant differences were noted between T1b-T2a (p=0.003) and T2b-T3 (p < 0.001) tumors, but not between Tis-T1a, T1a-T1b, and T2a-T2b tumors. However, significant survival differences were observed both by the overall and pair-wise (T1-T2, T2-T3) comparisons (all, p < 0.001) without dividing T1/T2 subcategories. When cases with ≥ 6 examined lymph nodes were evaluated, significant survival differences were observed among the entire comparison (p < 0.001) and pair-wise comparisons of N0-N1 (p=0.001) and N1-N2 (p=0.039) lesions. When cases without nodal dissection (NX) were additionally compared, significant survival differences were observed between patients with N0-NX (p=0.001) and NX-N1 (p < 0.001) lesions.
Conclusion
The T category in the 8th edition of the AJCC staging system did not completely stratify the prognosis of patients with gallbladder cancer. Modification by eliminating T subcategories can better stratify the prognosis. In contrast, the N category clearly determines patients’ survival with ≥ 6 examined lymph nodes. The survival time in patients of gallbladder cancers without nodal dissection is between N0 and N1 cases. Therefore, close postoperative followed up is recommended for those patients. -
Citations
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Montserrat Chavez, Xabier de Aretxabala, Hector Losada, Norberto Portillo, Felipe Castillo, Luis Bustos, Ivan Roa
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Clinical & Experimental Metastasis.2025;[Epub] CrossRef - Stage Evaluation of Cystic Duct Cancer
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The American Surgeon™.2024; 90(6): 1133. CrossRef - DNMT3A Cooperates with YAP/TAZ to Drive Gallbladder Cancer Metastasis
Sunwang Xu, Zhiqing Yuan, Cen Jiang, Wei Chen, Qiwei Li, Tao Chen
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Nunzio F Franco, Ngee-Soon Lau, Wai M Liu, Aadil Rahim, Mitali Fadia, Yu Jo Chua, Ankit Jain, Desmond Yip, Sivakumar Gananadha
Langenbeck's Archives of Surgery.2024;[Epub] CrossRef - Case and Management Considerations of Low‐Grade Cystic Duct Stump Dysplasia after Laparoscopic Cholecystectomy
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Giacomo C. Waller, Umut Sarpel
Surgical Clinics of North America.2024; 104(6): 1263. CrossRef - Robotic resection for gallbladder cancer: Superior lymphadenectomy does not equal better survival
Michela Fabricius, Amika Ekanem, Allison N. Martin
Surgery.2024; 176(4): 1016. CrossRef - Comparison of Prognostic Performance of 8th and 7th Edition of AJCC Staging System for Patients With Gallbladder Cancer Undergoing Curative Intent Surgery
Sameer Gupta, Abhishek Verma, Arun Chaturvedi, Puneet Prakash, Vijay Kumar, Sanjeev Misra, Naseem Akhtar, Shiv Rajan, Preeti Agarwal, Lynette Smith, Makayla Schissel, Chandrakanth Are
Journal of Surgical Oncology.2024;[Epub] CrossRef - Prognostic utility of the modified albumin-bilirubin score among patients undergoing curative-intent surgery for gallbladder cancer
Odysseas P. Chatzipanagiotou, Diamantis I. Tsilimigras, Giovanni Catalano, Andrea Ruzzenente, Federico Aucejo, Hugo P. Marques, Vincent Lam, Nazim Bhimani, Shishir K. Maithel, Itaru Endo, Minoru Kitago, Timothy M. Pawlik
Journal of Gastrointestinal Surgery.2024; 28(12): 2075. CrossRef - A Single-Center Analysis of Patient Characteristics and Overall Survival in Patients with Resectable Gallbladder Cancer
N. Begüm Öztürk, Artem Dadamyan, Laith H. Jamil
Healthcare.2024; 12(20): 2091. CrossRef - Survival Predictors of Resectable Gallbladder Carcinoma: An Analysis of the Surveillance, Epidemiology, and End Results Database
Jisheng Zhu, Yunxiang Wu, Weidong Xiao, Yong Li
The American Surgeon™.2023; 89(5): 1629. CrossRef - Reappraisal of T1b gallbladder cancer (GBC): clinicopathologic analysis of 473 in situ and invasive GBCs and critical review of the literature highlights its rarity, and that it has a very good prognosis
Burcin Pehlivanoglu, Gizem Akkas, Bahar Memis, Olca Basturk, Michelle D. Reid, Burcu Saka, Nevra Dursun, Pelin Bagci, Serdar Balci, Juan Sarmiento, Shishir K. Maithel, Sudeshna Bandyopadhyay, Oscar Tapia Escalona, Juan Carlos Araya, Hector Losada, Michael
Virchows Archiv.2023; 482(2): 311. CrossRef - Subserosal vascular density predicts oncological features of T2 gallbladder cancer
Miho Akabane, Junichi Shindoh, Kei Kohno, Satoshi Okubo, Masaru Matsumura, Yutaka Takazawa, Masaji Hashimoto
Langenbeck's Archives of Surgery.2023;[Epub] CrossRef - Standardized lymph node dissection for gallbladder cancer under laparoscopy: en-bloc resection technique
Jian Cheng, Jie Liu, Chang-Wei Dou, Zhong-Chun Xie, Bing-Fu Fan, Li-Ming Jin, Lei Liang, Cheng-Wu Zhang
Langenbeck's Archives of Surgery.2023;[Epub] CrossRef - Development and validation of an online dynamic prognostic nomogram for incidental gallbladder adenocarcinoma patients without distant metastasis after surgery: a population-based study
Jie Chen, Yehong Han
Frontiers in Medicine.2023;[Epub] CrossRef - Effects of Cystic Duct Margin Involvement on the Survival Rates of Patients With Gallbladder Cancer: A Propensity Score-Matched Case-Control Study
Vasistha Jajal, Phani K Nekarakanti, Sugumaran K, Hirdaya Nag
Cureus.2023;[Epub] CrossRef - Laparoskopik Kolesistektomi Yapılan Hastalarda Rastlantısal Safra Kesesi Kanseri Sıklığı
Serkan ERKAN, Hakan YABANOĞLU
Harran Üniversitesi Tıp Fakültesi Dergisi.2023; 20(3): 593. CrossRef - Utility of 18-Flurodeoxyglucose Positron Emission Tomography-Computed Tomography (18FDG PET-CT) in Gallbladder Cancer: Experience from a Tertiary Care Hospital
Niharika Bisht, Nishant Lohia, Sankalp Singh, Arti Sarin, Abhishek Mahato, Dharmesh Paliwal, Indranil Sinha, Sharad Bhatnagar
World Journal of Nuclear Medicine.2023; 22(04): 276. CrossRef - Lymphadenectomy in gallbladder adenocarcinoma: Are we doing enough?
Marianna V. Papageorge, Susanna W.L. de Geus, Alison P. Woods, Sing Chau Ng, F. Thurston Drake, Andrea Merrill, Michael R. Cassidy, David McAneny, Jennifer F. Tseng, Teviah E. Sachs
The American Journal of Surgery.2022; 224(1): 423. CrossRef - Systematic review and meta-analysis of survival outcomes in T2a and T2b gallbladder cancers
Wasfi Alrawashdeh, Sivesh K. Kamarajah, Rohan R. Gujjuri, William A. Cambridge, Shailesh V. Shrikhande, Alice C. Wei, Mohamed Abu Hilal, Steve A. White, Sanjay Pandanaboyana
HPB.2022; 24(6): 789. CrossRef - Examination of the characteristics of long-term survivors among patients with gallbladder cancer with liver metastasis who underwent surgical treatment: a retrospective multicenter study (ACRoS1406)
Ryota Higuchi, Hiroaki Ono, Ryusei Matsuyama, Yusuke Takemura, Shinjiro Kobayashi, Takehito Otsubo, Yuta Abe, Itaru Endo, Minoru Tanabe, Masakazu Yamamoto
BMC Gastroenterology.2022;[Epub] CrossRef - Development and validation of a prognostic nomogram for gallbladder cancer patients after surgery
Xinsen Xu, Min He, Hui Wang, Ming Zhan, Linhua Yang
BMC Gastroenterology.2022;[Epub] CrossRef - Transcription factor 4 expression and correlation with tumor progression in gallbladder cancer
Kaushik Neogi, Mallika Tewari, Ashish Kumar Singh, Kavyanjali Sharma, Gullanki Naga Venkata Charan Tej, Sumit Singh Verma, Subash Chandra Gupta, Prasanta Kumar Nayak
Journal of Cancer Research and Therapeutics.2022; 18(3): 668. CrossRef - Postsurgical radiotherapy in stage IIIB gallbladder cancer patients with one to three lymph nodes metastases: A propensity score matching analysis
Yu-Long Cai, Yi-Xin Lin, Xian-Ze Xiong, Hui Ye, Fu-Yu Li, Nan-Sheng Cheng
The American Journal of Surgery.2021; 221(3): 642. CrossRef - S100P as a marker for poor survival and advanced stage in gallbladder carcinoma
Alka Mary Mathai, Jacob Alexander, Hsuan-Ying Huang, Chien-Feng Li, Yung-Ming Jeng, Kar-Ming Fung, William P. Harris, Paul E. Swanson, Camtu Truong, Matthew M. Yeh
Annals of Diagnostic Pathology.2021; 52: 151736. CrossRef - The 8th Edition American Joint Committee on Cancer Staging for Hepato-pancreato-biliary Cancer: A Review and Update
Xiaoyan Liao, Dongwei Zhang
Archives of Pathology & Laboratory Medicine.2021; 145(5): 543. CrossRef - Expression of HER2 and Mismatch Repair Proteins in Surgically Resected Gallbladder Adenocarcinoma
You-Na Sung, Sung Joo Kim, Sun-Young Jun, Changhoon Yoo, Kyu-Pyo Kim, Jae Hoon Lee, Dae Wook Hwang, Shin Hwang, Sang Soo Lee, Seung-Mo Hong
Frontiers in Oncology.2021;[Epub] CrossRef - Prognostic Significance of Tumor Location in T2 Gallbladder Cancer: A Systematic Review and Meta-Analysis
Hyun Kang, Yoo Shin Choi, Suk-Won Suh, Geunjoo Choi, Jae Hyuk Do, Hyoung-Chul Oh, Hong Jin Kim, Seung Eun Lee
Journal of Clinical Medicine.2021; 10(15): 3317. CrossRef - A Clinical-Radiomics Nomogram for Preoperative Prediction of Lymph Node Metastasis in Gallbladder Cancer
Xingyu Liu, Xiaoyuan Liang, Lingxiang Ruan, Sheng Yan
Frontiers in Oncology.2021;[Epub] CrossRef - Manejo endoscópico de adenocarcinoma de vesícula biliar. Presentación de caso
Cristina Fernández-González de la Vega, Víctor Hugo Hernández-Lozada
Revista Mexicana de Cirugía Endoscópica.2021; 22(1): 28. CrossRef
- T1b gallbladder cancer: is extended resection warranted?
- 9,830 View
- 217 Download
- 33 Web of Science
- 32 Crossref
- An Integrated Nomogram Combining Clinical Factors and Microtubule-Associated Protein 1 Light Chain 3B Expression to Predict Postoperative Prognosis in Patients with Intrahepatic Cholangiocarcinoma
- Liang Chen, Hongyuan Fu, Tongyu Lu, Jianye Cai, Wei Liu, Jia Yao, Jinliang Liang, Hui Zhao, Jiebin Zhang, Jun Zheng, Yingcai Zhang, Yang Yang
- Cancer Res Treat. 2020;52(2):469-480. Published online October 7, 2019
- DOI: https://doi.org/10.4143/crt.2019.423
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Microtubule-associated protein 1 light chain 3B (LC3B) serves as a key component of autophagy, which is associated with the progression of carcinoma. Yet, it is still unclear whether LC3B is also an independent risk factor for intrahepatic cholangiocarcinoma (ICC). We aim to explore the predictive value of LC3B on prognosis of ICC, and to establish a novel and available nomogram to predict relapse-free survival (RFS) and overall survival (OS) for these patients after curative-intent hepatectomy.
Materials and Methods
From August 2004 to March 2017, 105 ICC patients were eligibly enrolled in the Third Affiliated Hospital of Sun Yat-sen University. Preoperative clinical information of enrolled patients was collected. Expression LC3B in the ICC specimen was detected by immunohistochemistry.
Results
The 5-year RFS and OS in this cohort were 15.7% and 29.6%, respectively. On multivariate Cox regression analysis, independent risk factors for 5-year OS were cancer antigen 125, microvascular invasion, LC3B expression and lymph node metastasis. Except for the above 4 factors, neutrophil/lymphocyte ratio and tumor differentiation were independent factors for 5-year RFS. The area under the curve of nomograms for OS and RFS were 0.820 and 0.747, respectively.
Conclusion
The nomograms based on LC3B can be considered as effective models to predict postoperative survival for ICC patients. -
Citations
Citations to this article as recorded by- Lymph node metastasis of intrahepatic cholangiocarcinoma: the present and prospect of detection and dissection
Ruoyu Zhang, Yunfei Tan, Mei Liu, Liming Wang
European Journal of Gastroenterology & Hepatology.2024; 36(12): 1359. CrossRef - Active Autophagy Is Associated with Favorable Outcome in Patients with Surgically Resected Cholangiocarcinoma
Katrin Bankov, Falko Schulze, Steffen Gretser, Henning Reis, Nada Abedin, Fabian Finkelmeier, Jörg Trojan, Stefan Zeuzem, Andreas A. Schnitzbauer, Dirk Walter, Peter J. Wild, Maximilian N. Kinzler
Cancers.2023; 15(17): 4322. CrossRef - The role and implication of autophagy in cholangiocarcinoma
Hayat Khizar, Yufei Hu, Yanhua Wu, Jianfeng Yang
Cell Death Discovery.2023;[Epub] CrossRef - Immunogenomics of cholangiocarcinoma
Virag Gehl, Colm J. O’Rourke, Jesper B. Andersen
Hepatology.2023;[Epub] CrossRef - Multiparametric MRI‐Based Radiomic Signature for Preoperative Evaluation of Overall Survival in Intrahepatic Cholangiocarcinoma After Partial Hepatectomy
Yang Yang, Xianlun Zou, Wei Zhou, Guanjie Yuan, Daoyu Hu, Dong Kuang, Yaqi Shen, Qingguo Xie, Qingpeng Zhang, Xuemei Hu, Zhen Li
Journal of Magnetic Resonance Imaging.2022; 56(3): 739. CrossRef - A Myeloid Signature-Based Nomogram Predicts the Postoperative Recurrence of Intrahepatic Cholangiocarcinoma
Jing Liang, Hui Zhou, Xiang-Qi Huang, Yan-Fei Liu, Lei Zhang, Dan He, Yongmei Cui, Jinrui Guo, Kunpeng Hu, Chong Wu
Frontiers in Molecular Biosciences.2021;[Epub] CrossRef - Therapeutic Potential of Autophagy Modulation in Cholangiocarcinoma
Hector Perez-Montoyo
Cells.2020; 9(3): 614. CrossRef
- Lymph node metastasis of intrahepatic cholangiocarcinoma: the present and prospect of detection and dissection
- 8,092 View
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- 8 Web of Science
- 7 Crossref
- Prevalence and Clinicopathological Significance of MET Overexpression and Gene Amplification in Patients with Gallbladder Carcinoma
- Yeseul Kim, Seong Sik Bang, Seungyun Jee, Sungeon Park, Su-Jin Shin, Kiseok Jang
- Cancer Res Treat. 2020;52(2):481-491. Published online October 24, 2019
- DOI: https://doi.org/10.4143/crt.2019.370
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Mesenchymal epithelial transition (MET) is a proto-oncogene that encodes a heterodimeric transmembrane receptor tyrosine kinase for the hepatocyte growth factor. Aberrant MET signaling has been described in several solid tumors—especially non-small cell lung cancer— and is associated with tumor progression and adverse prognosis. As MET is a potential therapeutic target, information regarding its prevalence and clinicopathological relevance is crucial.
Materials and Methods
We investigated MET expression and gene amplification in 113 gallbladder cancers using tissue microarray. Immunohistochemistry was used to evaluate MET overexpression, and silver/fluorescence in situ hybridization (ISH) was used to assess gene copy number.
Results
MET overexpression was found in 37 cases of gallbladder carcinoma (39.8%), and gene amplification was present in 17 cases (18.3%). MET protein expression did not correlate with MET amplification. MET amplification was significantly associated with aggressive clinicopathological features, including high histological grade, advanced pT category, lymph node metastasis, and advanced American Joint Committee on Cancer stage. There was no significant correlation between any clinicopathological factors and MET overexpression. No difference in survival was found with respect to MET overexpression and amplification status.
Conclusion
Our data suggested that MET might be a potential therapeutic target for targeted therapy in gallbladder cancer, because MET amplification was found in a subset of tumors associated with adverse prognostic factors. Detection of MET amplification by ISH might be a useful predictive biomarker test for anti-MET therapy. -
Citations
Citations to this article as recorded by- Genomic and molecular landscape of gallbladder cancer elucidating pathogenic mechanisms novel therapeutic targets and clinical implications
Manishankar Kumar, Arun Kumar, Abhinav Srivastav, Ashok Ghosh, Dhruv Kumar
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.2025; 830: 111896. CrossRef - Structure based multi-targeted screening, docking, DFT and simulation of anticancer natural compounds against gallbladder cancer
Suchitra Singh, Janhavi Yadav, Surbhi Singh, Sumanta Kumar Sahu, Puneet Puneet, Royana Singh
In Silico Pharmacology.2025;[Epub] CrossRef - MET alterations detection platforms and clinical implications in solid tumors: a comprehensive review of literature
Pei Yuan, Xuemin Xue, Tian Qiu, Jianming Ying
Therapeutic Advances in Medical Oncology.2024;[Epub] CrossRef - EGFR, HER2, and MET gene amplification and protein expression profiles in biliary tract cancer and their prognostic significance
Yeseul Kim, Seungyun Jee, Hyunsung Kim, Seung Sam Paik, Dongho Choi, Su Hyun Yoo, Su-Jin Shin
The Oncologist.2024; 29(8): e1051. CrossRef - Mesenchymal-epithelial transition factor amplification correlates with adverse pathological features and poor clinical outcome in colorectal cancer
Qiu-Xiao Yu, Ping-Ying Fu, Chi Zhang, Li Li, Wen-Ting Huang
World Journal of Gastrointestinal Surgery.2024; 16(5): 1395. CrossRef - Which therapy in biliary tract cancer? Review of main concerns in diagnosis and choice of therapy in advanced setting, current standard, and new options
Ester Oneda, Serena Astore, Laura Gandolfi, Laura Melocchi, Alberto Zaniboni
Expert Opinion on Pharmacotherapy.2024; 25(13): 1807. CrossRef - Acquired MET amplification in non-small cell lung cancer is highly associated with the exposure of EGFR inhibitors and may not affect patients' outcome
Wei Yin, Wei Liu, Ming Guo, Zhenya Tang, Gokce Toruner, Melissa Robinson, Joanne Cheng, Shimin Hu, L. Jeffrey Medeiros, Guilin Tang
Experimental and Molecular Pathology.2021; 118: 104572. CrossRef - Novel biomarkers for the diagnosis and prognosis of gallbladder cancer
Hong Ze Lin, Tao Zhang, Ming Yu Chen, Ji Liang Shen
Journal of Digestive Diseases.2021; 22(2): 62. CrossRef - A case report of response to crizotinib in chemotherapy-refractory metastatic gallbladder cancer with met amplification and acquired resistance resulting from the loss of MET amplification
Hongna Sun, Xiaofen Li, Shuang Dai, Xudong Shen, Meng Qiu
Precision Clinical Medicine.2021; 4(3): 209. CrossRef - Molecular Targets and Emerging Therapies for Advanced Gallbladder Cancer
Matteo Canale, Manlio Monti, Ilario Giovanni Rapposelli, Paola Ulivi, Francesco Giulio Sullo, Giulia Bartolini, Elisa Tiberi, Giovanni Luca Frassineti
Cancers.2021; 13(22): 5671. CrossRef - Testing for ROS1, ALK, MET, and HER2 rearrangements and amplifications in a large series of biliary tract adenocarcinomas
Jeremy Augustin, Caroline Gabignon, Aurélie Scriva, Laëtitia Menu, Claire Calmel, Olivier Scatton, François Paye, Jean-François Fléjou, Françoise Praz, Pascale Cervera, Dominique Wendum
Virchows Archiv.2020; 477(1): 33. CrossRef - Targeted-gene sequencing of an undifferentiated gallbladder carcinoma: a case report
Ying Xiao, Canhong Xiang, Di Yang, Benqi Zhao, Yong Li, Hongfang Yin
Diagnostic Pathology.2020;[Epub] CrossRef - Overview of current targeted therapy in gallbladder cancer
Xiaoling Song, Yunping Hu, Yongsheng Li, Rong Shao, Fatao Liu, Yingbin Liu
Signal Transduction and Targeted Therapy.2020;[Epub] CrossRef
- Genomic and molecular landscape of gallbladder cancer elucidating pathogenic mechanisms novel therapeutic targets and clinical implications
- 10,958 View
- 224 Download
- 13 Web of Science
- 13 Crossref
- EBV-miR-BHRF1-1 Targets p53 Gene: Potential Role in Epstein-Barr Virus Associated Chronic Lymphocytic Leukemia
- Dan-Min Xu, Yi-Lin Kong, Li Wang, Hua-Yuan Zhu, Jia-Zhu Wu, Yi Xia, Yue Li, Shu-Chao Qin, Lei Fan, Jian-Yong Li, Jin-Hua Liang, Wei Xu
- Cancer Res Treat. 2020;52(2):492-504. Published online October 29, 2019
- DOI: https://doi.org/10.4143/crt.2019.457
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
The purpose of this study was to investigate the prognostic impact of Epstein-Barr virus (EBV)–microRNA (miRNA, miR)-BHRF1-1 with chronic lymphocytic leukemia (CLL) as well as role of EBV-miR-BHRF1-1 in p53 gene.
Materials and Methods
Quantitative reverse transcription–polymerase chain reaction and western blotting were used to quantify EBV-miR-BHRF1-1 and p53 expression in cultured CLL.
Results
p53 aberration was associated with the higher expression level of EBV-miR-BHRF1-1 (p < 0.001) which was also an independent prognostic marker for overall survival (p=0.028; hazard ratio, 5.335; 95% confidence interval, 1.193 to 23.846) in 97 newly-diagnosed CLL patients after adjusted with International Prognostic Index for patients with CLL. We identified EBV-miR-BHRF1-1 as a viral miRNA regulator of p53. EBV-miR-BHRF1-1 repressed luciferase reporter activity by specific interaction with the seed region within the p53 3′- untranslated region. Discordance of p53 messenger RNA and protein expression was associated with high EBV-miR-BHRF1-1 levels in CLL patients and cell lines. EBV-miR-BHRF1- 1 inhibition upregulated p53 protein expression, induced cell cycle arrest and apoptosis and decreased cell proliferation in cell lines. EBV-miR-BHRF1-1 mimics downregulated p53 protein expression, decreased cell cycle arrest and apoptosis, and induced cell proliferation in cell lines.
Conclusion
This study supported the role of EBV-miR-BHRF1-1 in p53 regulation in vitro. Our results support the potential of EBV-miR-BHRF1-1 as a therapeutic target in EBV-associated CLL with p53 gene aberration. -
Citations
Citations to this article as recorded by- A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection
Seyedeh Zahra Bahojb Mahdavi, Asiyeh Jebelli, Parisa Shiri Aghbash, Behzad Baradaran, Mohammad Amini, Fatemeh Oroojalian, Nasser Pouladi, Hossein Bannazadeh Baghi, Miguel de la Guardia, Amir Ali Mokhtarzadeh
Medicinal Research Reviews.2025; 45(2): 349. CrossRef - USP7 Inhibitors Destabilize EBNA1 and Suppress Epstein‐Barr Virus Tumorigenesis
Christopher Chen, Kush Addepalli, Samantha S. Soldan, Leonardo Josue Castro‐ Munoz, Sarah Preston‐Alp, Rishi J. Patel, Coltin J. Albitz, Hsin‐Yao Tang, Italo Tempera, Paul M. Lieberman
Journal of Medical Virology.2025;[Epub] CrossRef - Longitudinal analysis of the impact of rituximab on circulating EBV miRNAs in three paediatric kidney transplant recipients
Jaythoon Hassan, Gabriel Gonzalez, Maria Stack, Niamh Dolan, Clodagh Sweeney, Cillian De Gascun, Jeff Connell, Atif Awan, Michael Riordan
Journal of Clinical Virology Plus.2024; 4(1): 100171. CrossRef - Epstein-Barr virus deubiquitinating enzyme BPLF1 is involved in EBV carcinogenesis by affecting cellular genomic stability
Hantao Wu, Bo-Wei Han, Tiancai Liu, Min Zhang, Yingsong Wu, Jing Nie
Neoplasia.2024; 55: 101012. CrossRef - The Emerging Role of Ferroptosis in EBV-Associated Cancer: Implications for Cancer Therapy
Shan He, Cheng Luo, Feng Shi, Jianhua Zhou, Li Shang
Biology.2024; 13(7): 543. CrossRef - From virus to cancer: Epstein–Barr virus miRNA connection in Burkitt's lymphoma
Shahram Jalilian, Mohammad-Navid Bastani
Infectious Agents and Cancer.2024;[Epub] CrossRef - MicroRNAs: Small but Key Players in Viral Infections and Immune Responses to Viral Pathogens
Anais N. Bauer, Niska Majumdar, Frank Williams, Smit Rajput, Lok R. Pokhrel, Paul P. Cook, Shaw M. Akula
Biology.2023; 12(10): 1334. CrossRef - Viral Encoded miRNAs in Tumorigenesis: Theranostic Opportunities in Precision Oncology
Rodney Hull, Rahaba Marima, Mohammed Alaouna, Demetra Demetriou, Rui Manuel Reis, Thulo Molefi, Zodwa Dlamini
Microorganisms.2022; 10(7): 1448. CrossRef - MicroRNAs: Tiny Regulators of Gene Expression with Pivotal Roles in Normal B-Cell Development and B-Cell Chronic Lymphocytic Leukemia
Katerina Katsaraki, Paraskevi Karousi, Pinelopi I. Artemaki, Andreas Scorilas, Vasiliki Pappa, Christos K. Kontos, Sotirios G. Papageorgiou
Cancers.2021; 13(4): 593. CrossRef - Metabolic Control by DNA Tumor Virus-Encoded Proteins
Martin A. Prusinkiewicz, Joe S. Mymryk
Pathogens.2021; 10(5): 560. CrossRef - Non-Coding RNAs: Strategy for Viruses’ Offensive
Alessia Gallo, Matteo Bulati, Vitale Miceli, Nicola Amodio, Pier Giulio Conaldi
Non-Coding RNA.2020; 6(3): 38. CrossRef - EBV-Positive Gastric Cancer: Current Knowledge and Future Perspectives
Keran Sun, Keqi Jia, Huifang Lv, Sai-Qi Wang, Yan Wu, Huijun Lei, Xiaobing Chen
Frontiers in Oncology.2020;[Epub] CrossRef
- A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection
- 7,454 View
- 210 Download
- 16 Web of Science
- 12 Crossref
- Concurrent and Adjuvant Temozolomide for Newly Diagnosed Grade III Gliomas without 1p/19q Co-deletion: A Randomized, Open-Label, Phase 2 Study (KNOG-1101 Study)
- Kihwan Hwang, Tae Min Kim, Chul-Kee Park, Jong Hee Chang, Tae-Young Jung, Jin Hee Kim, Do-Hyun Nam, Se-Hyuk Kim, Heon Yoo, Yong-Kil Hong, Eun-Young Kim, Dong-Eun Lee, Jungnam Joo, Yu Jung Kim, Gheeyoung Choe, Byung Se Choi, Seok-Gu Kang, Jeong Hoon Kim, Chae-Yong Kim
- Cancer Res Treat. 2020;52(2):505-515. Published online October 28, 2019
- DOI: https://doi.org/10.4143/crt.2019.421
-
Abstract
PDFPubReaderePub
- Purpose
We investigated the efficacy of temozolomide during and after radiotherapy in Korean adults with anaplastic gliomas without 1p/19q co-deletion.
Materials and Methods
This was a randomized, open-label, phase 2 study and notably the first multicenter trial for Korean grade III glioma patients. Eligible patients were aged 18 years or older and had newly diagnosed non-co-deleted anaplastic glioma with an Eastern Cooperative Oncology Group performance status of 0-2. Patients were randomized 1:1 to receive radiotherapy alone (60 Gy in 30 fractions of 2 Gy) (control group, n=44) or to receive radiotherapy with concurrent temozolomide (75 mg/m2/day) followed by adjuvant temozolomide (150-200 mg/m2/day for 5 days during six 28-day cycles) (treatment group, n=40). The primary end-point was 2-year progression-free survival (PFS). Seventy patients (83.3%) were available for the analysis of the isocitrate dehydrogenase 1 gene (IDH1) mutation status.
Results
The two-year PFS was 42.2% in the treatment group and 37.2% in the control group. Overall survival (OS) did not reach to significant difference between the groups. In multivariable analysis, age was a significant risk factor for PFS (hazard ratio [HR], 2.08; 95% confidence interval [CI], 1.04 to 4.16). The IDH1 mutation was the only significant prognostic factor for PFS (HR, 0.28; 95% CI, 0.13 to 0.59) and OS (HR, 0.19; 95% CI, 0.07 to 0.50). Adverse events over grade 3 were seen in 16 patients (40.0%) in the treatment group and were reversible.
Conclusion
Concurrent and adjuvant temozolomide in Korean adults with newly diagnosed non-co- deleted anaplastic gliomas showed improved 2-year PFS. The survival benefit of this regimen needs further analysis with long-term follow-up at least more than 10 years. -
Citations
Citations to this article as recorded by- Impact of upfront adjuvant chemoradiation on survival in patients with molecularly defined oligodendroglioma: the benefits of PCV over TMZ
Jordina Rincon-Torroella, Maureen Rakovec, Anita L. Kalluri, Kelly Jiang, Carly Weber-Levine, Megan Parker, Divyaansh Raj, Josh Materi, Sadra Sepehri, Abel Ferres, Karisa C. Schreck, Iban Aldecoa, Calixto-Hope G. Lucas, Haris I. Sair, Kristin J. Redmond,
Journal of Neuro-Oncology.2025; 171(1): 35. CrossRef - Multidisciplinary Management of Isocitrate Dehydrogenase–Mutated Gliomas in a Contemporary Molecularly Defined Era
Rupesh Kotecha, David Schiff, Arnab Chakravarti, Jessica L. Fleming, Paul D. Brown, Vinay K. Puduvalli, Michael A. Vogelbaum, Vinai Gondi, Marco Gallus, Hideho Okada, Minesh P. Mehta
Journal of Clinical Oncology.2024; 42(21): 2588. CrossRef - The IDH paradox: Meta-analysis of alkylating chemotherapy in IDH-wild type and -mutant lower grade gliomas
Connor J Kinslow, Soumyajit Roy, Fabio M Iwamoto, Paul D Brown, David M DeStephano, Peter D Canoll, Summer S Qureshi, Matthew Gallito, Michael B Sisti, Jeffrey N Bruce, David P Horowitz, Lisa A Kachnic, Alfred I Neugut, James B Yu, Minesh P Mehta, Simon K
Neuro-Oncology.2024; 26(10): 1839. CrossRef - The Role of Systemic Therapies in the Treatment of Grades 1-4 Gliomas
Jan Stepka, Mariusz Dotka, Maciej Kosiński, Piotr Suchecki, Maciej Hobot, Igor Piotrowski
Cureus.2024;[Epub] CrossRef - Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline
Nimish A. Mohile, Hans Messersmith, Na Tosha Gatson, Andreas F. Hottinger, Andrew Lassman, Jordan Morton, Douglas Ney, Phioanh Leia Nghiemphu, Adriana Olar, Jeffery Olson, James Perry, Jana Portnow, David Schiff, Anne Shannon, Helen A. Shih, Roy Strowd, M
Journal of Clinical Oncology.2022; 40(4): 403. CrossRef - Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline
Nimish A Mohile, Hans Messersmith, Na Tosha N Gatson, Andreas F Hottinger, Andrew B Lassman, Jordan Morton, Douglas Ney, Phioanh Leia Nghiemphu, Adriana Olar, Jeffery Olson, James Perry, Jana Portnow, David Schiff, Anne Shannon, Helen A Shih, Roy Strowd,
Neuro-Oncology.2022; 24(3): 358. CrossRef - Executive summary of American Radium Society’s appropriate use criteria for the postoperative management of lower grade gliomas
Martin C. Tom, Michael T. Milano, Samuel T. Chao, Scott G. Soltys, Jonathan P.S. Knisely, Arjun Sahgal, Seema Nagpal, Simon S. Lo, Siavash Jabbari, Tony J.C. Wang, Manmeet S. Ahluwalia, Marian Simonson, Joshua D. Palmer, Melanie Hayden Gephart, Lia M. Hal
Radiotherapy and Oncology.2022; 170: 79. CrossRef - Influence of Concurrent and Adjuvant Temozolomide on Health-Related Quality of Life of Patients with Grade III Gliomas: A Secondary Analysis of a Randomized Clinical Trial (KNOG-1101 Study)
Grace S. Ahn, Kihwan Hwang, Tae Min Kim, Chul Kee Park, Jong Hee Chang, Tae-Young Jung, Jin Hee Kim, Do-Hyun Nam, Se-Hyuk Kim, Heon Yoo, Yong-Kil Hong, Eun-Young Kim, Dong-Eun Lee, Jungnam Joo, Yu Jung Kim, Gheeyoung Choe, Byung Se Choi, Seok-Gu Kang, Jeo
Cancer Research and Treatment.2022; 54(2): 396. CrossRef - The Risk of Heart Disease-Related Death Among Anaplastic Astrocytoma Patients After Chemotherapy: A SEER Population-Based Analysis
Qi Lin, Jia-Hao Bao, Fei Xue, Jia-Jun Qin, Zhen Chen, Zhong-Rong Chen, Chao Li, Yi-Xuan Yan, Jin Fu, Zhao-Li Shen, Xian-Zhen Chen
Frontiers in Oncology.2022;[Epub] CrossRef - Association between a prior cancer history and prognosis in adult patients with high‑grade glioma
Dongjie He, Peiwen Wu, Gaiyan Li, Siying Zhu, Qiming Wang, Qiuju Shao, Hao Chang
Journal of Clinical Neuroscience.2022; 106: 20. CrossRef
- Impact of upfront adjuvant chemoradiation on survival in patients with molecularly defined oligodendroglioma: the benefits of PCV over TMZ
- 9,807 View
- 635 Download
- 10 Web of Science
- 10 Crossref
- Pretreatment Lymph Node Metastasis as a Prognostic Significance in Cervical Cancer: Comparison between Disease Status
- Soo Young Jeong, Hyea Park, Myeong Seon Kim, Jun Hyeok Kang, E Sun Paik, Yoo-Young Lee, Tae Joong Kim, Jeong Won Lee, Byoung-Gie Kim, Duk Soo Bae, Chel Hun Choi
- Cancer Res Treat. 2020;52(2):516-523. Published online October 29, 2019
- DOI: https://doi.org/10.4143/crt.2019.328
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Lymph node metastasis (LNM) is the most significant prognostic factor in cervical cancer that was recently incorporated into the International Federation of Gynecology and Obstetrics (FIGO) staging system. This study was performed to evaluate whether the prognostic significance of LNM differs according to disease status.
Materials and Methods
Patients with FIGO stage IB or higher cervical cancer who had pretreatment computed tomography and/or magnetic resonance imaging studies as well as long-term follow-up were enrolled in this retrospective study. The hazard ratio (HR) of Cox regression was used to determine the prognostic significance of LNM. The HRs were compared between the different tumor groups (based on stage, histology, tumor size, primary treatment, age, parametrium involvement, and lymphovascular space invasion).
Results
A total of 970 patients treated between January 1999 and December 2007 were included. The pretreatment LNM had prognostic significance in patients with stage IB1/IIA (HR for progression-free survival 2.10, p=0.001; HR for overall survival 1.99, p=0.005). However, the significance gradually decreased or disappeared with advancing stages. Similarly, the prognostic significance of the pretreatment LNM decreased with advancing disease status, including old age, parametrial involvement or lymphovascular space involvement. In contrast, the tumor size was associated with the prognostic significance of LNM with advancing status. The significance of the clinical LNM did not reflect the significance of the clinical stage. In contrast, the tumor size, parametrial involvement, and significance of the pathologic LNM reflected the clinical stage.
Conclusion
In patients with cervical cancer, pretreatment LNM on imaging has different clinical significance depending on the tumor status. -
Citations
Citations to this article as recorded by- Development of cervical intraepithelial neoplasia and invasive cervical cancer due to oxidative stress
Amir Asotić, Memić Asotić, Muhamed Memić, Kerim Asotić, Amra Asotić
Sanamed.2024; 19(1): 39. CrossRef - Investigating and Analyzing Prognostic Factors and Their Impact on Recurrent Cervical Cancers
Ashish Uke, Shweta B Dahake, Anurag Luharia, Monika Luharia, Gaurav V Mishra, Chanrashekhar Mahakalkar
Cureus.2024;[Epub] CrossRef - Based on 3D-PDU and clinical characteristics nomogram for prediction of lymph node metastasis and lymph-vascular space invasion of early cervical cancer preoperatively
Shuang Dong, Yan-Qing Peng, Ya-Nan Feng, Xiao-Ying Li, Li-Ping Gong, Shuang Zhang, Xiao-Shan Du, Li-Tao Sun
BMC Women's Health.2024;[Epub] CrossRef - Recent Advances in Cervical Cancer Management: A Review on Novel Prognostic Factors in Primary and Recurrent Tumors
Angela Santoro, Frediano Inzani, Giuseppe Angelico, Damiano Arciuolo, Emma Bragantini, Antonio Travaglino, Michele Valente, Nicoletta D’Alessandris, Giulia Scaglione, Stefania Sfregola, Alessia Piermattei, Federica Cianfrini, Paola Roberti, Gian Franco Za
Cancers.2023; 15(4): 1137. CrossRef - Identification of lymph node metastasis in pre‐operation cervical cancer patients by weakly supervised deep learning from histopathological whole‐slide biopsy images
Qingqing Liu, Nan Jiang, Yiping Hao, Chunyan Hao, Wei Wang, Tingting Bian, Xiaohong Wang, Hua Li, Yan zhang, Yanjun Kang, Fengxiang Xie, Yawen Li, XuJi Jiang, Yuan Feng, Zhonghao Mao, Qi Wang, Qun Gao, Wenjing Zhang, Baoxia Cui, Taotao Dong
Cancer Medicine.2023; 12(17): 17952. CrossRef - Roles of DWI and T2-weighted MRI volumetry in the evaluation of lymph node metastasis and lymphovascular invasion of stage IB–IIA cervical cancer
Y. Wang, X. Chen, H. Pu, Y. Yuan, S. Li, G. Chen, Y. Liu, H. Li
Clinical Radiology.2022; 77(3): 224. CrossRef - Risk Factor Assessment of Lymph Node Metastasis in Patients With FIGO Stage IB1 Cervical Cancer
Mu Xu, Xiaoyan Xie, Liangzhi Cai, Yongjin Xie, Qiao Gao, Pengming Sun
Frontiers in Oncology.2022;[Epub] CrossRef - Intravoxel Incoherent Motion (IVIM) MR Quantification in Locally Advanced Cervical Cancer (LACC): Preliminary Study on Assessment of Tumor Aggressiveness and Response to Neoadjuvant Chemotherapy
Miriam Dolciami, Silvia Capuani, Veronica Celli, Alessandra Maiuro, Angelina Pernazza, Innocenza Palaia, Violante Di Donato, Giusi Santangelo, Stefania Maria Rita Rizzo, Paolo Ricci, Carlo Della Rocca, Carlo Catalano, Lucia Manganaro
Journal of Personalized Medicine.2022; 12(4): 638. CrossRef - The prognostic significance of pretreatment squamous cell carcinoma antigen levels in cervical cancer patients treated by concurrent chemoradiation therapy and a comparison of dosimetric outcomes and clinical toxicities between tomotherapy and volumetric
Yuan-Kai Cheng, Shih-Hsun Kuo, Heng-Hsuan Yen, Jing-Hu Wu, Yu-Chieh Chen, Ming-Yii Huang
Radiation Oncology.2022;[Epub] CrossRef - What MRI-based tumor size measurement is best for predicting long-term survival in uterine cervical cancer?
Njål Lura, Kari S. Wagner-Larsen, David Forsse, Jone Trovik, Mari K. Halle, Bjørn I. Bertelsen, Øyvind Salvesen, Kathrine Woie, Camilla Krakstad, Ingfrid S. Haldorsen
Insights into Imaging.2022;[Epub] CrossRef - Clinical value of MRI, serum SCCA, and CA125 levels in the diagnosis of lymph node metastasis and para-uterine infiltration in cervical cancer
Chao Ran, Jian Sun, Yunhui Qu, Na Long
World Journal of Surgical Oncology.2021;[Epub] CrossRef - A Novel Four-Gene Prognostic Signature as a Risk Biomarker in Cervical Cancer
Jun Wang, Hua Zheng, Yatian Han, Geng Wang, Yanbin Li, Cuida Meng
International Journal of Genomics.2020; 2020: 1. CrossRef
- Development of cervical intraepithelial neoplasia and invasive cervical cancer due to oxidative stress
- 10,413 View
- 223 Download
- 14 Web of Science
- 12 Crossref
- Interim Tumor Progression and Volumetric Changes of Surgical Cavities during the Surgery-to-Radiotherapy Interval in Anaplastic Gliomas: Implications for Additional Pre-radiotherapy Magnetic Resonance Imaging
- Chan Woo Wee, Il Han Kim, Chul-Kee Park, Jin Wook Kim
- Cancer Res Treat. 2020;52(2):524-529. Published online October 31, 2019
- DOI: https://doi.org/10.4143/crt.2019.520
-
Abstract
PDFPubReaderePub
- Purpose
This study was designed to investigate the incidence of interim disease progression (IPD) and volumetric changes of the surgical cavity (SC) during the surgery-to-radiotherapy interval (SRI), and eventually assess the value of magnetic resonance imaging (MRI) at the time of radiotherapy (RT) planning in newly diagnosed anaplastic gliomas.
Materials and Methods
Among 195 anaplastic glioma patients who underwent RT, 121 were evaluable with two separate MRIs during SRI. The presence of IPD was determined using the updated Response Assessment in Neuro-Oncology size criteria. In 84 patients who underwent surgical resection, each SC was contoured by a radiation oncologist and the volumetric changes of the SCs were calculated between the two separate MRIs. Daily rate of change in the SC volume was calculated assuming an exponential and linear change.
Results
Five of 121 patients (4.13%) demonstrated IPD during SRI, and the incidence was significantly higher in patients undergoing biopsy (vs. surgical resection, 12.9% vs. 1.1%, p=0.015) and in patients with remnant contrast-enhancing tumor after surgery (15.8 vs. 2.0%, p=0.027). The mean daily rate of absolute change in SC was 1.06% (95% confidence interval [CI], 0.89 to 1.23) and 0.89% (95% CI, 0.77 to 1.02) according to the exponential and linear model, respectively. The expected mean volumetric change at 2 weeks were 16.64% (95% CI, 13.77 to 19.52) and 12.51% (95% CI, 10.77 to 14.26), respectively.
Conclusion
IPD during the SRI is rare in surgically resected anaplastic gliomas. However, pre-RT MRI is essential for accurate RT-target delineation and disease evaluation for patients initiating RT beyond postoperative 2 weeks and undergoing biopsy, respectively. -
Citations
Citations to this article as recorded by- Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial
Stefan Dietzsch, Annett Braesigk, Clemens Seidel, Julia Remmele, Ralf Kitzing, Tina Schlender, Martin Mynarek, Dirk Geismar, Karolina Jablonska, Rudolf Schwarz, Montserrat Pazos, Damien C. Weber, Silke Frick, Kristin Gurtner, Christiane Matuschek, Semi Be
Strahlentherapie und Onkologie.2022; 198(3): 282. CrossRef - Effect of 3D Slicer Preoperative Planning and Intraoperative Guidance with Mobile Phone Virtual Reality Technology on Brain Glioma Surgery
Jun Liu, Xiaodong Li, Xueping Leng, Bo Zhong, Yanhong Liu, Liang Liu, Mohammad Farukh Hashmi
Contrast Media & Molecular Imaging.2022;[Epub] CrossRef
- Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial
- 5,713 View
- 165 Download
- 2 Web of Science
- 2 Crossref
- A Radiosensitivity Gene Signature and PD-L1 Status Predict Clinical Outcome of Patients with Glioblastoma Multiforme in The Cancer Genome Atlas Dataset
- Bum-Sup Jang, In Ah Kim
- Cancer Res Treat. 2020;52(2):530-542. Published online November 20, 2019
- DOI: https://doi.org/10.4143/crt.2019.440
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Combination of radiotherapy and immune checkpoint blockade such as programmed death- 1 (PD-1) or programmed death-ligand 1 (PD-L1) blockade is being actively tested in clinical trial. We aimed to identify a subset of patients that could potentially benefit from this strategy using The Cancer Genome Atlas (TCGA) dataset for glioblastoma (GBM).
Materials and Methods
A total of 399 cases were clustered into radiosensitive versus radioresistant (RR) groups based on a radiosensitivity gene signature and were also stratified as PD-L1 high versus PD-L1 low groups by expression of CD274 mRNA. Differential and integrated analyses with expression and methylation data were performed. CIBERSORT was used to enumerate the immune repertoire that resulted from transcriptome profiles.
Results
We identified a subset of GBM, PD-L1-high-RR group which showed worse survival compared to others. In PD-L1-high-RR, differentially expressed genes (DEG) were highly enriched for immune response and mapped into activation of phosphoinositide 3-kinase–AKT and mitogen-activated protein kinase (MAPK) signaling pathways. Integration of DEG and differentially methylated region identified that the kinase MAP3K8-involved in T-cell receptor signaling was upregulated and BAI1, a factor which inhibits angiogenesis, was silenced. CIBERSORT showed that a higher infiltration of the immune repertoire, which included M2 macrophages and regulatory T cells.
Conclusion
Taken together, PD-L1-high-RR group could potentially benefit from radiotherapy combined with PD-1/PD-L1 blockade and angiogenesis inhibition. -
Citations
Citations to this article as recorded by- Clinical Biomarkers of Tumour Radiosensitivity and Predicting Benefit from Radiotherapy: A Systematic Review
Christopher W. Bleaney, Hebatalla Abdelaal, Mark Reardon, Carmel Anandadas, Peter Hoskin, Ananya Choudhury, Laura Forker
Cancers.2024; 16(10): 1942. CrossRef - A retrospective cohort study of neoadjuvant chemoradiotherapy combined with immune checkpoint inhibitors in locally advanced rectal cancer
Zhuo Chen, Zhuoling Zou, Min Qian, Qin Xu, Guojuan Xue, Juan Yang, Tinglan Luo, Lianjie Hu, Bin Wang
Translational Oncology.2024; 44: 101955. CrossRef - Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives
Hao Lin, Chaxian Liu, Ankang Hu, Duanwu Zhang, Hui Yang, Ying Mao
Journal of Hematology & Oncology.2024;[Epub] CrossRef - PSF-lncRNA interaction as a target for novel targeted anticancer therapies
Ren Liu, Xiaojing Wang, Min Zhou, Jingfang Zhai, Jie Sun
Biomedicine & Pharmacotherapy.2024; 180: 117491. CrossRef - Bladder Cancer Treatments in the Age of Personalized Medicine: A Comprehensive Review of Potential Radiosensitivity Biomarkers
Charbel Feghaly, Rafka Challita, Hanine Bou Hadir, Tala Mobayed, Tarek Al Bitar, Mohammad Harbi, Hala Ghorayeb, Rana El-Hassan, Larry Bodgi
Biomarker Insights.2024;[Epub] CrossRef - Improving the efficacy of combined radiotherapy and immunotherapy: focusing on the effects of radiosensitivity
Zhiru Gao, Qian Zhao, Yiyue Xu, Linlin Wang
Radiation Oncology.2023;[Epub] CrossRef - In Vivo Evaluation of Near-Infrared Fluorescent Probe for TIM3 Targeting in Mouse Glioma
Michael Zhang, Quan Zhou, Chinghsin Huang, Carmel T. Chan, Wei Wu, Gordon Li, Michael Lim, Sanjiv S. Gambhir, Heike E. Daldrup-Link
Molecular Imaging and Biology.2022; 24(2): 280. CrossRef - Relationship between Macrophage and Radiosensitivity in Human Primary and Recurrent Glioblastoma: In Silico Analysis with Publicly Available Datasets
Bum-Sup Jang, In Ah Kim
Biomedicines.2022; 10(2): 292. CrossRef - Optimal management of recurrent and metastatic upper tract urothelial carcinoma: Implications of intensity modulated radiation therapy
Mi Sun Kim, Woong Sub Koom, Jae Ho Cho, Se-Young Kim, Ik Jae Lee
Radiation Oncology.2022;[Epub] CrossRef - Translational landscape of glioblastoma immunotherapy for physicians: guiding clinical practice with basic scientific evidence
Daniel Kreatsoulas, Chelsea Bolyard, Bill X. Wu, Hakan Cam, Pierre Giglio, Zihai Li
Journal of Hematology & Oncology.2022;[Epub] CrossRef - The Next Frontier in Health Disparities—A Closer Look at Exploring Sex Differences in Glioma Data and Omics Analysis, from Bench to Bedside and Back
Maria Diaz Rosario, Harpreet Kaur, Erdal Tasci, Uma Shankavaram, Mary Sproull, Ying Zhuge, Kevin Camphausen, Andra Krauze
Biomolecules.2022; 12(9): 1203. CrossRef - Immunosuppression in Gliomas via PD-1/PD-L1 Axis and Adenosine Pathway
Thamiris Becker Scheffel, Nathália Grave, Pedro Vargas, Fernando Mendonça Diz, Liliana Rockenbach, Fernanda Bueno Morrone
Frontiers in Oncology.2021;[Epub] CrossRef - The Combination of Radiotherapy With Immunotherapy and Potential Predictive Biomarkers for Treatment of Non-Small Cell Lung Cancer Patients
Lu Meng, Jianfang Xu, Ying Ye, Yingying Wang, Shilan Luo, Xiaomei Gong
Frontiers in Immunology.2021;[Epub] CrossRef - Explore association of genes in PDL1/PD1 pathway to radiotherapy survival benefit based on interaction model strategy
Junjie Shen, Jingfang Liu, Huijun Li, Lu Bai, Zixuan Du, Ruirui Geng, Jianping Cao, Peng Sun, Zaixiang Tang
Radiation Oncology.2021;[Epub] CrossRef - Combination of Radiosensitivity Gene Signature and PD-L1 Status Predicts Clinical Outcome of Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma: A Study Based on The Cancer Genome Atlas Dataset
Dongjun Dai, Yinglu Guo, Yongjie Shui, Jinfan Li, Biao Jiang, Qichun Wei
Frontiers in Molecular Biosciences.2021;[Epub] CrossRef Prognostic Values of Radiosensitivity Genes and CD19 Status in Gastric Cancer: A Retrospective Study Using TCGA Database
Li-Bo Liang, Xin-Yan Huang, He He, Ji-Yan Liu
Pharmacogenomics and Personalized Medicine.2020; Volume 13: 365. CrossRef- Gene signature based on B cell predicts clinical outcome of radiotherapy and immunotherapy for patients with lung adenocarcinoma
Linzhi Han, Hongjie Shi, Yuan Luo, Wenjie Sun, Shuying Li, Nannan Zhang, Xueping Jiang, Yan Gong, Conghua Xie
Cancer Medicine.2020; 9(24): 9581. CrossRef
- Clinical Biomarkers of Tumour Radiosensitivity and Predicting Benefit from Radiotherapy: A Systematic Review
- 7,827 View
- 261 Download
- 19 Web of Science
- 17 Crossref
- Detection of Targetable Genetic Alterations in Korean Lung Cancer Patients: A Comparison Study of Single-Gene Assays and Targeted Next-Generation Sequencing
- Eunhyang Park, Hyo Sup Shim
- Cancer Res Treat. 2020;52(2):543-551. Published online November 8, 2019
- DOI: https://doi.org/10.4143/crt.2019.305
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), and ROS proto-oncogene 1 (ROS1) are ‘must-test’ biomarkers in the molecular diagnostics of advanced-stage lung cancer patients. Although single-gene assays are currently considered the gold standard for these genes, next-generation sequencing (NGS) tests are being introduced to clinical practices. We compared the results of current diagnostics and aimed to suggest timely effective guidance for their clinical use.
Materials and Methods
Patients with lung cancer who received both conventional single-gene assays and subsequent targeted NGS testing were enrolled, and the results of their tests were compared.
Results
A total of 241 patients were enrolled, and the EGFR real-time polymerase chain reaction, ALK fluorescence in situ hybridization (FISH), and ROS1 FISH assays exhibited 92.9%, 99.6%, and 99.5% concordance with the NGS tests, respectively. The discordant cases were mostly false-negatives of the single-gene assays, probably due to technical limitation. Of 158 cases previously designated as wild-type, EGFR, ALK, and ROS1 alterations were identified in 10.1%, 1.9%, and 1.3%, respectively, and other targetable alterations were identified in 36.1% of the cases. Of patients with additionally identified actionable alterations, 32.6% (31/95) received matched therapy with a clinical benefit of 48.4% (15/31).
Conclusion
Even though the conventional and NGS methods were concordant in the majority of cases, NGS testing still revealed a considerable number of additional EGFR, ALK, and ROS1 alterations, as well as other targetable alterations, in Korean advanced-stage lung cancer patients. Given the high frequency of EGFR and other targetable mutations identified in the present study, NGS testing is highly recommended in the diagnosis of Korean lung cancer patients. -
Citations
Citations to this article as recorded by- Clinical Impact of Genomic and Pathway Alterations in Stage I EGFR-Mutant Lung Adenocarcinoma
Jae Seok Lee, Eun Kyung Kim, Kyung A Kim, Hyo Sup Shim
Cancer Research and Treatment.2024; 56(1): 104. CrossRef - Prognostic value of preoperative circulating tumor DNA in non-small cell lung cancer: a systematic review and meta-analysis
Jiamin Lu, Yuqian Feng, Kaibo Guo, Leitao Sun, Shanming Ruan, Kai Zhang
Journal of Cancer Research and Clinical Oncology.2024;[Epub] CrossRef - Cost-effectiveness of next-generation sequencing for advanced EGFR/ALK-negative non-small cell lung cancer
Dong-Won Kang, Sun-Kyeong Park, Sokbom Kang, Eui-Kyung Lee
Lung Cancer.2024; 197: 107970. CrossRef - Upfront liquid next-generation sequencing in treatment-naïve advanced non-small cell lung cancer patients: A prospective randomised study in the Taiwanese health system
Ching-Yao Yang, Jin-Yuan Shih, Wei-Yu Liao, Chao-Chi Ho, Chia-Lin Hsu, Tzu-Hsiu Tsai, Shang-Gin Wu, Yen-Ting Lin, Wei-Hsun Hsu, Suyog Jain, Steve Olsen, James Chih-Hsin Yang, Chong-Jen Yu, Pan-Chyr Yang
European Journal of Cancer.2023; 193: 113310. CrossRef - Clinicopathological Characteristics of NRG1 Fusion–Positive Solid Tumors in Korean Patients
Yoon Jin Cha, Chung Lee, Bio Joo, Kyung A Kim, Choong-kun Lee, Hyo Sup Shim
Cancer Research and Treatment.2023; 55(4): 1087. CrossRef - Differences in genomic profile of high-grade urothelial carcinoma according to tumor location
Cheol Keun Park, Nam Hoon Cho
Urologic Oncology: Seminars and Original Investigations.2022; 40(3): 109.e1. CrossRef - Comparison of the Data of a Next-Generation Sequencing Panel from K-MASTER Project with That of Orthogonal Methods for Detecting Targetable Genetic Alterations
Yoon Ji Choi, Jung Yoon Choi, Ju Won Kim, Ah Reum Lim, Youngwoo Lee, Won Jin Chang, Soohyeon Lee, Jae Sook Sung, Hee-Joon Chung, Jong Won Lee, Eun Joo Kang, Jung Sun Kim, Taekyu Lim, Hye Sook Kim, Yu Jung Kim, Mi Sun Ahn, Young Saing Kim, Ji Hyun Park, Se
Cancer Research and Treatment.2022; 54(1): 30. CrossRef - Increased Radiosensitivity of Solid Tumors Harboring ATM and BRCA1/2 Mutations
Kyung Hwan Kim, Han Sang Kim, Seung-seob Kim, Hyo Sup Shim, Andrew Jihoon Yang, Jason Joon Bock Lee, Hong In Yoon, Joong Bae Ahn, Jee Suk Chang
Cancer Research and Treatment.2022; 54(1): 54. CrossRef - Utility of Single-Gene Testing in Cancer Specimens
Mehenaz Hanbazazh, Diana Morlote, Alexander C. Mackinnon, Shuko Harada
Clinics in Laboratory Medicine.2022; 42(3): 385. CrossRef - Landscape of EGFR mutations in lung adenocarcinoma: a single institute experience with comparison of PANAMutyper testing and targeted next-generation sequencing
Jeonghyo Lee, Yeon Bi Han, Hyun Jung Kwon, Song Kook Lee, Hyojin Kim, Jin-Haeng Chung
Journal of Pathology and Translational Medicine.2022; 56(5): 249. CrossRef - Plasma tumor mutation burden is associated with clinical benefit in patients with non-small cell lung cancer treated with anti-programmed death-1 monotherapy
Jii Bum Lee, Hyung Soon Park, Su Jin Choi, Seong Gu Heo, Ho Jung An, Hye Ryun Kim, Min Hee Hong, Sun Min Lim, Kyle Chang, Katie Quinn, Justin Odegaard, Byoung Yong Shim, Byoung Chul Cho
Therapeutic Advances in Medical Oncology.2022;[Epub] CrossRef - Afatinib treatment in a lung adenocarcinoma patient harboring a rare EGFR L747P mutation
Jisheng Li, Liping Zhu, Justin Stebbing, Ling Peng
Journal of Cancer Research and Therapeutics.2022; 18(5): 1436. CrossRef - Lung cancer pathogenesis and poor response to therapy were dependent on driver oncogenic mutations
Xin Sun, Kai Li, Rui Zhao, Ye Sun, Jie Xu, Zi-Yang Peng, Run-Dong Song, Hong Ren, Shou-Ching Tang
Life Sciences.2021; 265: 118797. CrossRef - Patient-Specific Multi-Omics Models and the Application in Personalized Combination Therapy
August John, Bo Qin, Krishna R Kalari, Liewei Wang, Jia Yu
Future Oncology.2020; 16(23): 1737. CrossRef - Genetic Markers in Lung Cancer Diagnosis: A Review
Katarzyna Wadowska, Iwona Bil-Lula, Łukasz Trembecki, Mariola Śliwińska-Mossoń
International Journal of Molecular Sciences.2020; 21(13): 4569. CrossRef
- Clinical Impact of Genomic and Pathway Alterations in Stage I EGFR-Mutant Lung Adenocarcinoma
- 8,767 View
- 269 Download
- 16 Web of Science
- 15 Crossref
- Impact of Prior Cancer History on the Clinical Outcomes in Advanced Breast Cancer: A Propensity Score–Adjusted, Population-Based Study
- Caijin Lin, Jiayi Wu, Shuning Ding, Chihwan Goh, Lisa Andriani, Kunwei Shen, Li Zhu
- Cancer Res Treat. 2020;52(2):552-562. Published online November 18, 2019
- DOI: https://doi.org/10.4143/crt.2019.210
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Despite the rapid growing of cancer survivors, prior cancer history is a commonly adopted exclusion criterion. Whether prior cancer will impact the survival of patients with advanced breast cancer (ABC) remains uncertain.
Materials and Methods
Patients with ABC diagnosed between 2004 and 2010 were identified using Surveillance, Epidemiology, and End Results (SEER) database. Timing, stage, and type were used to characterize prior cancer. Multivariable analyses using propensity score–adjusted Cox regression and competing risk regression were conducted to evaluate the prognostic effect of prior cancer on overall survival (OS) and breast cancer-specific survival (BCSS).
Results
A total of 14,176 ABC patients were identified, of whom 10.5% carried a prior cancer history. The most common type of prior cancer was female genital cancer (32.4%); more than half (51.7%) were diagnosed at localized stage; most were diagnosed more than 5 years (42.9%) or less than 1 year (28.3%) prior to the index cancer. In multivariate analyses, patients with prior cancer presented a slightly worse OS (hazard ratio, 1.18; 95% confidence interval [CI], 1.07 to 1.30; p=0.001) but a better BCSS (subdistribution hazard ratio, 0.64; 95% CI, 0.56 to 0.74; p < 0.001). In subset analyses, no survival detriment was observed in patients with prior malignancy from head and neck or endocrine system, at in situ or localized stage, or diagnosed more than 4 years.
Conclusion
Prior cancer provides an inferior OS but a superior BCSS for patients with ABC. It does not affect the survival adversely in some subgroups and these patients should not be excluded from clinical trials. -
Citations
Citations to this article as recorded by- Impact of childhood/adolescent cancer history on prognosis in parotid mucoepidermoid carcinoma
Hefeng Gu, Sunyi Tu, Lan Ma, Kuiwei Su, Yeqing Zhou
British Journal of Oral and Maxillofacial Surgery.2024; 62(7): 612. CrossRef - Medical history of thyroid cancer does not impair prognosis in non-metastatic breast cancer patients: an analysis study based on SEER database and external cohort
Shuai Li, Xiaosong Chen, Kunwei Shen
Frontiers in Oncology.2024;[Epub] CrossRef - Clinical characteristics and prostate-cancer-specific mortality of competitive risk nomogram in the second primary prostate cancer
Chaojie Xu, Dongchen Pei, Yi Liu, Jianhua Guo, Nan Liu, Qian Wang, Yang Yu, Zhengjun Kang
Frontiers in Oncology.2023;[Epub] CrossRef - The Impact of a History of Different Other Cancers on the Long-Term Outcomes of Patients with Gallbladder Cancer: A Propensity Score–Adjusted, Population-Based Study
Jing Wang, Chan Zhang, Dong Yan
Technology in Cancer Research & Treatment.2023;[Epub] CrossRef - Second primary malignancies in oral tongue cancer: A Surveillance, Epidemiology, and End Result–based analysis evaluating the basic characteristics, survival outcomes, and predictive factors
Zicheng Xu, Jianxing Wang, Hongzhou Cai, Feng Qi, Qing Zou
Precision Medical Sciences.2022; 11(1): 4. CrossRef - Better Prognosis and Survival in Esophageal Cancer Survivors After Comorbid Second Primary Malignancies: A SEER Database-Based Study
Jiayue Ye, Sheng Hu, Wenxiong Zhang, Deyuan Zhang, Yang Zhang, Dongliang Yu, Jinhua Peng, Jianjun Xu, Yiping Wei
Frontiers in Surgery.2022;[Epub] CrossRef - [Retracted] Effect of Previous Cancer History on Survival of Patients with Different Subtypes of Breast Cancer
Weixun Lin, Yaokun Chen, Zeqi Ji, Lingzhi Chen, Jinyao Wu, Yexi Chen, Zhiyang Li, Nauman Rahim Khan
BioMed Research International.2022;[Epub] CrossRef - Association between a prior cancer history and prognosis in adult patients with high‑grade glioma
Dongjie He, Peiwen Wu, Gaiyan Li, Siying Zhu, Qiming Wang, Qiuju Shao, Hao Chang
Journal of Clinical Neuroscience.2022; 106: 20. CrossRef - Impact of prior cancer history on survival of patients with gastric cancer
Li Wen, Kun Yu, Hongjiang Lu, Guansheng Zhong
European Journal of Surgical Oncology.2021; 47(9): 2286. CrossRef - Effect of prior cancer on survival outcomes for patients with advanced prostate cancer
Yechen Wu, Xi Chen, Duocheng Qian, Wei Wang, Yiping Zhang, Jinxin Hu, Jun Zhu, Qiang Wu, Tinghu Cao
BMC Urology.2021;[Epub] CrossRef - Survival of women diagnosed with breast cancer and who have survived a previous cancer
Sandi L. Pruitt, Hong Zhu, Daniel F. Heitjan, Asal Rahimi, Bhumika Maddineni, Anna Tavakkoli, Ethan A. Halm, David E. Gerber, Danyi Xiong, Caitlin C. Murphy
Breast Cancer Research and Treatment.2021; 187(3): 853. CrossRef - Trends in the proportion of second or later primaries among all newly diagnosed malignant cancers
Chelsea Anderson, Deborah K. Mayer, Hazel B. Nichols
Cancer.2021; 127(15): 2736. CrossRef - Survival analysis of patients with primary breast duct carcinoma and lung adenocarcinoma: a population-based study from SEER
Fengyuan Lv, Mingliang Cheng, Liang Jiang, Xiaoping Zhao
Scientific Reports.2021;[Epub] CrossRef - Research on Effectiveness of Prior Cancer on Survival Outcomes for Patients with Nonmetastatic Triple-Negative Breast Cancer: A Competing Risk Analysis and Propensity Score Matching Analysis of the SEER Database
Heyan Chen, Lutong Yan, Shengyu Pu, Lizhe Zhu, Huimin Zhang, Can Zhou, Raffaele Palmirotta
Journal of Oncology.2021; 2021: 1. CrossRef - Risk of breast cancer-related death in women with a prior cancer
Fei Ji, Ci-Qiu Yang, Xiao-Ling Li, Liu-Lu Zhang, Mei Yang, Jie-Qing Li, Hong-Fei Gao, Teng Zhu, Min-Yi Cheng, Wei-Ping Li, Si-Yan Wu, Ai-Ling Zhong, Kun Wang
Aging.2020; 12(7): 5894. CrossRef
- Impact of childhood/adolescent cancer history on prognosis in parotid mucoepidermoid carcinoma
- 8,305 View
- 178 Download
- 18 Web of Science
- 15 Crossref
- Association of Body Composition with Long-Term Survival in Non-metastatic Rectal Cancer Patients
- Jin Soo Han, Hyoseon Ryu, In Ja Park, Kyung Won Kim, Yongbin Shin, Sun Ok Kim, Seok-Byung Lim, Chan Wook Kim, Yong Sik Yoon, Jong Lyul Lee, Chang Sik Yu, Jin Cheon Kim
- Cancer Res Treat. 2020;52(2):563-572. Published online December 3, 2019
- DOI: https://doi.org/10.4143/crt.2019.249
-
Abstract
PDFPubReaderePub
- Purpose
We evaluated the association of body composition with long-term oncologic outcomes in non-metastatic rectal cancer patients.
Methods
We included 1,384 patients with stage(y)0-III rectal cancer treated at Asan Medical Center between January 2005 and December 2012. Body composition at diagnosis was measured using abdomino-pelvic computed tomography (CT). Sarcopenia, visceral obesity (VO), and sarcopenic obesity (SO) were defined using CT measured parameters such as skeletal muscle index (total abdominal muscle area, TAMA), visceral fat area (VFA), and VFA/TAMA. Inflammatory status was defined as a neutrophil-lymphocyte ratio of ≥3. Obesity was categorized by body mass index (≥ 25 kg/m2).
Results
Among the 1,384 patients, 944 (68.2%) had sarcopenia and 307 (22.2%) had SO. The 5-year overall survival (OS) rate was significantly lower in sarcopenic patients (no sarcopenia vs. sarcopenia; 84% vs. 78%, p=0.003) but the 5-year recurrence-free survival (RFS) rate was not different (77.3% vs. 77.9% p=0.957). Patients with SO showed lower 5-year OS (79.1% vs. 75.5% p=0.02) but no difference in 5-year RFS (p=0.957). Sarcopenia, SO, VO, and obesity were not associated with RFS. However, obesity, SO, age, sex, inflammatory status, and tumor stage were confirmed as independent factors associated with OS on multivariate analysis. In subgroup analysis, association of SO with OS was more prominent in patients with (y)p stage 0-2 and no inflammatory status.
Conclusion
The presence of SO and a low body mass index at diagnosis are negatively associated with OS in non-metastatic rectal cancer patients. -
Citations
Citations to this article as recorded by- Prognostic Impact of Sarcopenic Obesity on Postoperative Outcomes in Colorectal Cancer Patients Undergoing Surgery: A Systematic Review and Meta-Analysis
Tuba Nur Yıldız Kopuz, Hanifi Furkan Yıldız, Sadettin Er, Mehmet Fisunoğlu
Nutrition and Cancer.2025; 77(3): 360. CrossRef - Effect of sarcopenic obesity on treatment results in patients with malignant tumors of the gastrointestinal tract: systematic review
T. S. Boldyreva, V. K. Lyadov
Supportive Therapy in Oncology.2025; 1(3): 26. CrossRef - Radiological Assessment of Sarcopenia and Its Clinical Impact in Patients with Hepatobiliary, Pancreatic, and Gastrointestinal Diseases: A Comprehensive Review
Shameema Farook, Saumya Soni, Arpit Shantagiri, Pankaj Gupta, Anindita Sinha, Mahesh Prakash
Journal of Gastrointestinal and Abdominal Radiology.2024; 07(01): 027. CrossRef - Landscape and research trends of sarcopenic obesity research: A bibliometric analysis
Huiyu Tang, Rongna Lian, Runjie Li, Jiaojiao Jiang, Ming Yang
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Qiutong Su, Jia Shen, Zubing Mei
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Constantinos Simillis, Beth Taylor, Ayesha Ahmad, Nikhil Lal, Thalia Afxentiou, Michael P. Powar, Elizabeth C. Smyth, Nicola S. Fearnhead, James Wheeler, Richard J. Davies
European Journal of Cancer.2022; 172: 237. CrossRef - Sarcobesity Index Predicts Poor Disease-Specific Survival After Resection for Colorectal Cancer
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Journal of Surgical Research.2022; 279: 398. CrossRef - Sarcopenic obesity and therapeutic outcomes in gastrointestinal surgical oncology: A meta-analysis
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Frontiers in Nutrition.2022;[Epub] CrossRef - Adiposity and cancer survival: a systematic review and meta-analysis
En Cheng, Jocelyn Kirley, Elizabeth M. Cespedes Feliciano, Bette J. Caan
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Young Il Kim, In Ja Park, Chan Wook Kim, Yong Sik Yoon, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim, Yura Lee, Harin Kim, Seockhoon Chung, Chang-Min Choi, Hui Jeong Lee, Kyung Won Kim, Yousun Ko, Sung-Cheol Yun, Min-Woo Jo, Jong Won Lee
Medicine.2022; 101(41): e31264. CrossRef - Serial Changes in Body Composition and the Association with Disease Activity during Treatment in Patients with Crohn’s Disease
Ji Young Lee, Kyung Won Kim, Yousun Ko, Chi Hyuk Oh, Bo Hyun Kim, Seong Jin Park, Myung-Won You
Diagnostics.2022; 12(11): 2804. CrossRef - Sarcopenia as a Prognostic Marker in Elderly Head and Neck Squamous Cell Carcinoma Patients Undergoing (Chemo-)Radiation
Erik Haehl, Luisa Alvino, Alexander Rühle, Jiadai Zou, Alexander Fabian, Anca-Ligia Grosu, Nils H. Nicolay
Cancers.2022; 14(22): 5536. CrossRef - Marked loss of adipose tissue during neoadjuvant therapy as a predictor for poor prognosis in patients with gastric cancer: A retrospective cohort study
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Journal of Human Nutrition and Dietetics.2021; 34(3): 585. CrossRef - Sarcopenia predicts worse postoperative outcomes and decreased survival rates in patients with colorectal cancer: a systematic review and meta-analysis
Mario Trejo-Avila, Katya Bozada-Gutiérrez, Carlos Valenzuela-Salazar, Jesús Herrera-Esquivel, Mucio Moreno-Portillo
International Journal of Colorectal Disease.2021; 36(6): 1077. CrossRef - Prognostic and predictive value of neutrophil-to-lymphocyte ratio after curative rectal cancer resection: A systematic review and meta-analysis
Hytham K.S. Hamid, George N. Davis, Mario Trejo-Avila, Patrick O. Igwe, Andrés Garcia-Marín
Surgical Oncology.2021; 37: 101556. CrossRef - The Role of Sarcopenic Obesity in Cancer and Cardiovascular Disease: A Synthesis of the Evidence on Pathophysiological Aspects and Clinical Implications
Erika Aparecida Silveira, Rômulo Roosevelt da Silva Filho, Maria Claudia Bernardes Spexoto, Fahimeh Haghighatdoost, Nizal Sarrafzadegan, Cesar de Oliveira
International Journal of Molecular Sciences.2021; 22(9): 4339. CrossRef - Influence of Postoperative Changes in Sarcopenia on Long-Term Survival in Non-Metastatic Colorectal Cancer Patients
Chungyeop Lee, In-Ja Park, Kyung-Won Kim, Yongbin Shin, Seok-Byung Lim, Chan-Wook Kim, Yong-Sik Yoon, Jong-Lyul Lee, Chang-Sik Yu, Jin-Cheon Kim
Cancers.2021; 13(10): 2410. CrossRef - Preoperative computed tomography-assessed sarcopenia as a predictor of complications and long-term prognosis in patients with colorectal cancer: a systematic review and meta-analysis
Hailun Xie, Lishuang Wei, Mingxiang Liu, Guanghui Yuan, Shuangyi Tang, Jialiang Gan
Langenbeck's Archives of Surgery.2021; 406(6): 1775. CrossRef - Methodology, clinical applications, and future directions of body composition analysis using computed tomography (CT) images: A review
Antti Tolonen, Tomppa Pakarinen, Antti Sassi, Jere Kyttä, William Cancino, Irina Rinta-Kiikka, Said Pertuz, Otso Arponen
European Journal of Radiology.2021; 145: 109943. CrossRef - Skeletal muscle gauge as a prognostic factor in patients with colorectal cancer
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Cancer Medicine.2021; 10(23): 8451. CrossRef - Sarcopenia as a predictor of mortality in women with breast cancer: a meta-analysis and systematic review
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BMC Cancer.2020;[Epub] CrossRef - Sarcopenia Is Associated With Hematologic Toxicity During Chemoradiotherapy in Patients With Anal Carcinoma
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Frontiers in Oncology.2020;[Epub] CrossRef
- Prognostic Impact of Sarcopenic Obesity on Postoperative Outcomes in Colorectal Cancer Patients Undergoing Surgery: A Systematic Review and Meta-Analysis
- 9,929 View
- 325 Download
- 47 Web of Science
- 49 Crossref
- A Modified NHL-BFM-95 Regimen Produces Better Outcome Than HyperCVAD in Adult Patients with T-Lymphoblastic Lymphoma, a Two-Institution Experience
- Chun Li, Zhi-Jun Wuxiao, Xiaoqin Chen, Guanjun Chen, Yue Lu, Zhongjun Xia, Yang Liang, Hua Wang
- Cancer Res Treat. 2020;52(2):573-585. Published online December 6, 2019
- DOI: https://doi.org/10.4143/crt.2019.542
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Lymphoblastic lymphoma (LBL) is an invasive neoplasm of precursor T-cell or B-cell lineage. A broadly accepted standard treatment for adult LBL has not yet been defined.
Materials and Methods
To address this issue, we compared two chemotherapy regimens: a modified non-Hodgkin lymphoma Berlin–Frankfurt–Münster-95 (NHL-BFM-95) regimen and HyperCVAD/MA. This retrospective study consecutively enrolled 207 adult LBL patients at two hospitals from 2000 to 2018. Univariate and multivariate analysis were used to assess prognostic factors.
Results
In the present study, most clinical characteristics were similar between the two treatment groups except for age and lactate dehydrogenase (LDH) level. Patients treated with modified NHL-BFM-95 regimen tended to be younger and with elevated LDH level. The modified NHL-BFM- 95 regimen produced better treatment outcomes than those with HyperCVAD/MA in patients with T-LBL or patients < 40 years. Treatment with HyperCVAD/MA, high Eastern Cooperative Oncology Group scores, and bone marrow involvement were independent risk factors in T-LBL. No patients interrupted treatment for severe adverse events.
Conclusion
The results suggested that the modified regimen is well-tolerated and can produce the promising outcomes in patients with T-LBL or patients < 40 years. -
Citations
Citations to this article as recorded by- Optimal timing and impact of allogeneic peripheral blood stem cell transplantation in adult T-cell lymphoblastic lymphoma: insights from a large cohort multi-center real-world study in Shanghai
Fangfang Yu, Jiahua Niu, Jianmin Yang, Jian Hou, Siguo Hao, Aibin Liang, Hong Xiong, Qi Zhu, Ligen Liu, Jun Shi, Juan Du, Bobin Chen, Rong Wei, Wenli Zhao, Lihua Sun, Yunhua Hou, Rong Tao, Xianmin Song
Bone Marrow Transplantation.2025; 60(3): 380. CrossRef - Cutaneous Involvement in a Case of T-lymphoblastic Lymphoma: A Rare Presentation
Priyanka Kowe, Madhusmita Sethy, Biswanath Behera, Pritinanda Mishra, Ashutosh Panigrahi
Indian Dermatology Online Journal.2025; 16(2): 326. CrossRef - The Efficacy of Pediatric‐Inspired Regimens vs. Hyper‐CVAD in the Treatment of Adolescents and Young Adults With Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis
Wenqing Su, Melisa Stricherz, Alison Martin, Jonathan Belsey, Eric Kemadjou, Daniel J. DeAngelo
American Journal of Hematology.2025; 100(5): 847. CrossRef - Superiority of allo-SCT to auto-SCT in high-risk T-cell lymphoblastic lymphoma/leukemia patients with aaIPI ≥3: insights from a retrospective, multicenter analysis
Xiaodan Luo, Zhiping Fan, Runhui Zheng, Fen Huang, Na Xu, Pengfei Qin, Jingren Lin, Chunyan Wang, Huiqiang Huang, Huo Tan, Qifa Liu
Blood Science.2025; 7(2): e00222. CrossRef - Subcutaneous panniculitis‐like T‐cell lymphoma in a young girl presenting with periorbital edema and fever: A case report
Seyed Mohamad Kazem Nourbakhsh, Mohammad Bahadoram, Farid Kosari, Mehrdad Jafari, Nahid Aslani, Shakiba Hassanzadeh
Clinical Case Reports.2022;[Epub] CrossRef - Comprehensive view on genetic features, therapeutic modalities and prognostic models in adult T-cell lymphoblastic lymphoma
Qihua Zou, Shuyun Ma, Xiaopeng Tian, Qingqing Cai
Blood Science.2022; 4(3): 155. CrossRef - Total Body Irradiation–Based Conditioning Regimen Improved the Survival of Adult Patients With T-Cell Lymphoblastic Lymphoma After Allogeneic Peripheral Blood Stem Cell Transplantation
Jiahua Niu, Zhixiao Chen, Jie Gao, Huiying Qiu, Liping Wan, Ying Wang, Wenwei Wang, Yin Tong, Chongmei Huang, Yu Cai, Xiaowei Xu, Kun Zhou, Ying Zhang, Xinxin Xia, Chang Shen, Yu Wei, Tingfeng Chen, Xianmin Song, Jun Yang
Cell Transplantation.2022;[Epub] CrossRef - Characteristics of growth disturbances in patients with intracranial germinomas of different origins
Bo Li, Jiayi Wang, Jiongxian Yang, Yanong Li, Yanwei Liu, Shuai Liu, Xiaoguang Qiu
Child's Nervous System.2021; 37(8): 2531. CrossRef - Event-free survival at 24 months is a robust surrogate endpoint for long-term survival in pediatric, adolescent, and adult T cell lymphoblastic lymphoma
Haizhu Chen, Yan Qin, Jianliang Yang, Peng Liu, Changgong Zhang, Xiaohui He, Shengyu Zhou, Sheng Yang, Lin Gui, Liqiang Zhou, Yan Sun, Yuankai Shi
Annals of Hematology.2020; 99(12): 2847. CrossRef
- Optimal timing and impact of allogeneic peripheral blood stem cell transplantation in adult T-cell lymphoblastic lymphoma: insights from a large cohort multi-center real-world study in Shanghai
- 8,421 View
- 168 Download
- 8 Web of Science
- 9 Crossref
- Risk Factors for Cognitive Impairment in High-Grade Glioma Patients Treated with Postoperative Radiochemotherapy
- Qiang Wang, Fengxia Xiao, Fei Qi, Xiaopeng Song, Yonghua Yu
- Cancer Res Treat. 2020;52(2):586-593. Published online December 12, 2019
- DOI: https://doi.org/10.4143/crt.2019.242
-
Abstract
PDFPubReaderePub
- Purpose
Fractionated radiotherapy as well as concomitant and adjuvant chemotherapy such as temozolomide for postoperative high-grade glioma (HGG) patients improves progression-free survival and overall survival. Multiple factors such as chemotherapy, radiotherapy, tumor grade, residual tumor volume, and genetic modifications might play a role in the formation of cognitive impairment. The risk factors of cognitive impairment in postoperative patients with HGG receiving radiotherapy and chemotherapy remains a concern in this population. The purpose of this study was to identify risk factors for cognitive impairment in patients of postoperative HGG.
Materials and Methods
A total of 229 patients with HGG who underwent surgery were analyzed. Cognitive impairment was defined as a decrease of Cognitive Assessment Montreal (MoCA)’s score in at least two cognitive domains or any MoCA’s score of less than 26 points at the time of study compared with baseline level. Multiple potential risk factors including methylated status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter, glioma World Health Organization (WHO) grade, residual tumor volume, education, and sex were analyzed. Cox univariate and multivariate regression analysis was used to detect the significant risk factors for cognitive impairment.
Results
At the end of follow-up among the 229 patients, 147 patients (67%) developed cognitive impairment. 82 patients (36%) remained in normal cognitive condition. In multivariate analysis, unmethylated MGMT promoter (hazard ratio [HR], 1.679; 95% confidence interval [CI], 1.212 to 2.326; p=0.002), glioblastoma (HR, 1.550; 95% CI, 1.117 to 2.149; p=0.009), and residual tumor volume > 5.58 cm3 (HR, 1.454; 95% CI, 1.047 to 2.020; p=0.026) were independent risk factors for cognitive impairment.
Conclusion
Methylated status of the MGMT promoter, glioma WHO grade, and residual tumor volume might be risk factors for the cognitive impairment in postoperative patients with HGG. -
Citations
Citations to this article as recorded by- The relationship between social participation and cognitive function early after surgery of glioma patients
Yinglian Xiao, Jing Tan, Guo Cheng, Yanhong Deng, Ryota Tamura
PLOS ONE.2025; 20(2): e0319220. CrossRef - BTK Expression Level Prediction and the High-Grade Glioma Prognosis Using Radiomic Machine Learning Models
Chenggang Jiang, Chen Sun, Xi Wang, Shunchang Ma, Wang Jia, Dainan Zhang
Journal of Imaging Informatics in Medicine.2024; 37(4): 1359. CrossRef - Epigenome-Wide Analysis of DNA Methylation and Optimism in Women and Men
Cuicui Wang, Dawn L. DeMeo, Eric S. Kim, Andres Cardenas, Kelvin C. Fong, Lewina O. Lee, Avron Spiro, Eric A. Whitsel, Steve Horvath, Lifang Hou, Andrea A. Baccarelli, Yun Li, James D. Stewart, JoAnn E. Manson, Francine Grodstein, Laura D. Kubzansky, Joel
Psychosomatic Medicine.2023; 85(1): 89. CrossRef - Factors affecting cognitive functions of patients with high-grade gliomas: a systematic review
Rabeet Tariq, Nowal Hussain, Muhammad Waqas Saeed Baqai
Neurological Sciences.2023; 44(6): 1917. CrossRef - Cognitive functioning in a cohort of high-grade glioma patients
Andreja Cirila Skufca Smrdel, Anja Podlesek, Marija Skoblar Vidmar, Jana Markovic, Jana Jereb, Manja Kuzma Okorn, Uros Smrdel
Radiology and Oncology.2023; 57(2): 201. CrossRef - Cognitive outcomes after multimodal treatment in adult glioma patients: A meta-analysis
Laurien De Roeck, Céline R Gillebert, Robbie C M van Aert, Amber Vanmeenen, Martin Klein, Martin J B Taphoorn, Karin Gehring, Maarten Lambrecht, Charlotte Sleurs
Neuro-Oncology.2023; 25(8): 1395. CrossRef - Factors Associated With Neurocognitive Impairment Following Chemoradiotherapy in Patients With High-Grade Glioma: Results of a Prospective Trial
Prashasti Sharma, Partha Pratim Medhi, Apurba Kumar Kalita, Mouchumee Bhattacharyya, Jyotiman Nath, Gautam Sarma, Yanpothung Yanthan
Brain Tumor Research and Treatment.2023; 11(3): 183. CrossRef - Knockdown of TRIM32 inhibits tumor growth and increases the therapeutic sensitivity to temozolomide in glioma in a p53-dependent and -independent manner
Yu Cai, Wei Ting Gu, Kang Cheng, Pei Feng Jia, Feng Li, Ming Wang, Wei Feng Zhang, Ji Ting Qiu, Zhe Bao Wu, Wei Guo Zhao
Biochemical and Biophysical Research Communications.2021; 550: 134. CrossRef - Sensitivity of the Montreal Cognitive Assessment in screening for cognitive impairment in patients with newly diagnosed high-grade glioma
Monica Ribeiro, Thomas Durand, Martine Roussel, Loïc Feuvret, Julian Jacob, Dimitri Psimaras, Georges Noel, Audrey Keller, Flavie Bompaire, Khê Hoang-Xuan, Marie-Odile Bernier, Olivier Godefroy, Damien Ricard
Journal of Neuro-Oncology.2020; 148(2): 335. CrossRef
- The relationship between social participation and cognitive function early after surgery of glioma patients
- 7,614 View
- 173 Download
- 12 Web of Science
- 9 Crossref
- Efficacy and Safety of Pembrolizumab in Patients with Refractory Advanced Biliary Tract Cancer: Tumor Proportion Score as a Potential Biomarker for Response
- Junho Kang, Jae Ho Jeong, Hee-Sang Hwang, Sang Soo Lee, Do Hyun Park, Dong Wook Oh, Tae Jun Song, Ki-Hun Kim, Shin Hwang, Dae Wook Hwang, Song Cheol Kim, Jin-hong Park, Seung-Mo Hong, Kyu-pyo Kim, Baek-Yeol Ryoo, Changhoon Yoo
- Cancer Res Treat. 2020;52(2):594-603. Published online December 18, 2019
- DOI: https://doi.org/10.4143/crt.2019.493
-
Abstract
PDFPubReaderePub
- Purpose
The current standard chemotherapy for advanced biliary tract cancer (BTC) has limited benefit, and novel therapies need to be investigated.
Materials and Methods
In this prospective cohort study, programmed death ligand-1 (PD-L1)–positive BTC patients who progressed on first-line gemcitabine plus cisplatin were enrolled. Pembrolizumab 200 mg was administered intravenously every 3 weeks.
Results
Between May 2018 and February 2019, 40 patients were enrolled. Pembrolizumab was given as second-line (47.5%) or ≥ third-line therapy (52.5%). The objective response rate was 10% and 12.5% by Response Evaluation Criteria in Solid Tumor (RECIST) v1.1 and immune- modified RECIST (imRECIST) and median duration of response was 6.3 months. Among patients with progressive disease as best response, one patient (1/20, 5.0%) achieved complete response subsequently. The median progression-free survival (PFS) and overall survival (OS) were 1.5 months (95% confidence interval [CI], 0.0 to 3.0) and 4.3 months (95% CI, 3.5 to 5.1), respectively, and objective response per imRECIST was significantly associated with PFS (p < 0.001) and OS (p=0.001). Tumor proportion score ≥ 50% was significantly associated with higher response rates including the response after pseudoprogression (vs. < 50%; 37.5% vs. 6.5%; p=0.049).
Conclusion
Pembrolizumab showed modest anti-tumor activity in heavily pretreated PD-L1–positive BTC patients. In patients who showed objective response, durable response could be achieved. -
Citations
Citations to this article as recorded by- Camrelizumab combined with gemcitabine and apatinib in treating advanced PD‐L1‐positive biliary tract cancers
Yitong Tian, Changxian Li, Ke Jin, Ling Ma, Jiaguang Zhang, Xinyi Zhang, Wei You, Haoyang Shen, Yuting Ding, Hao Qian, Xiangcheng Li, Xiaofeng Chen
Cancer Science.2025; 116(1): 204. CrossRef -
Ex vivo liver resection and auto-transplantation and special systemic therapy in perihilar cholangiocarcinoma treatment
Konstantin Y Tchilikidi
World Journal of Gastrointestinal Surgery.2024; 16(3): 635. CrossRef - The predictive value of PD-L1 expression in response to anti-PD-1/PD-L1 therapy for biliary tract cancer: a systematic review and meta-analysis
Seung Bae Yoon, Sang Myung Woo, Jung Won Chun, Dong Uk Kim, Jaihwan Kim, Joo Kyung Park, Hoonsub So, Moon Jae Chung, In Rae Cho, Jun Heo
Frontiers in Immunology.2024;[Epub] CrossRef - Unveiling the promise of PD1/PD-L1: A new dawn in immunotherapy for cholangiocarcinoma
Fei Chen, Jian Sheng, Xiaoping Li, Zhaofeng Gao, Siqi Zhao, Lingyu Hu, Minjie Chen, Jianguo Fei, Zhengwei Song
Biomedicine & Pharmacotherapy.2024; 175: 116659. CrossRef - Clinical outcomes of immune checkpoint inhibitor combined with other targeted or immunological therapy regimens for the treatment of advanced bile tract cancer: a systematic review and meta-analysis
Jianpeng Zhou, Jia Li, Zhongqi Fan, Guoyue Lv, Guangyi Wang
Frontiers in Immunology.2024;[Epub] CrossRef - The Immune Landscape and Its Potential for Immunotherapy in Advanced Biliary Tract Cancer
Andry Santoso, Iris Levink, Rille Pihlak, Ian Chau
Current Oncology.2024; 32(1): 24. CrossRef - Emerging pharmaceutical therapies for targeting cholangiocarcinoma microenvironment and chemokine pathways
ARMAND N. YAZDANI, MICHAELA PLETSCH, ABRAHAM CHORBAJIAN, DAVID ZITSER, VIKRANT RAI
BIOCELL.2024; 48(12): 1683. CrossRef - Anti-PD-1-based immunotherapy plus lenvatinib to treat advanced gallbladder cancer in the elderly: a case series and review of current literature
Lantian Wang, Kezhong Tang, Xiawei Li, Wenjie Lu
Journal of Cancer Research and Clinical Oncology.2023; 149(3): 941. CrossRef - A prospective multicenter phase II study of FOLFIRINOX as a first-line treatment for patients with advanced and recurrent biliary tract cancer
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- Activation of Tyrosine Metabolism in CD13+ Cancer Stem Cells Drives Relapse in Hepatocellular Carcinoma
- Li Sun, Lin Zhang, Jun Chen, Chaoqun Li, Hongqin Sun, Jiangrong Wang, Hong Xiao
- Cancer Res Treat. 2020;52(2):604-621. Published online December 27, 2019
- DOI: https://doi.org/10.4143/crt.2019.444
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Cancer stem cells (CSCs) are naturally resistant to chemotherapy, explaining why tumor relapse frequently occurs after initial regression upon administration of chemotherapeutic agents in most cases. A CSC population characterized by CD13 expression has been identified in hepatocellular carcinoma (HCC). In the current study, we aimed to clarify the molecular mechanism by which it escapes conventional therapies. Materials and Methods Here, we used flow cytometry to examine the percentage of CD13+ CSCs in HepG2 and HuH7 cells after chemotherapy. Using in vitro isotope labeling technique, we compared metabolic pathways between CD13+ and CD13– subpopulations. Using co-immunoprecipitation and western blotting, we determined the target expressions in protein levels under different conditions. We also performed immunohistochemistry to detect the target proteins under different conditions. Animal models were constructed to verify the potential role of tyrosine metabolism in post-chemotherapeutic relapse in vivo.
Results
We observed that quiescent CD13+ CSCs are enriched after chemotherapy in HCCs, and serve as a reservoir for recurrence. Mechanistically, CD13+ CSCs were dependent on aerobic metabolism of tyrosine rather than glucose as energy source. Tyrosine metabolism also generated nuclear acetyl-CoA to acetylate and stabilize Foxd3, thereby allowing CD13+ CSCs cells to sustain quiescence and resistance to chemotherapeutic agents.
Conclusion
These findings encourage further exploration of eliminating CD13+ cells by targeting specific metabolic pathways to prevent recurrence in HCCs. -
Citations
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Shuai Cheng, Jian Yu, Meiling Cui, Hongmin Su, Yang Cao
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- CXCL-13 Regulates Resistance to 5-Fluorouracil in Colorectal Cancer
- Guolin Zhang, Xin Luo, Wei Zhang, Engeng Chen, Jianbin Xu, Fei Wang, Gaoyang Cao, Zhenyu Ju, Dongai Jin, Xuefeng Huang, Wei Zhou, Zhangfa Song
- Cancer Res Treat. 2020;52(2):622-633. Published online December 31, 2019
- DOI: https://doi.org/10.4143/crt.2019.593
-
Abstract
PDFPubReaderePub
- Purpose
5-Fluorouracil (5-Fu) is used as a conventional chemotherapy drug in chemotherapy for patients with advanced colorectal cancer, but many patients still suffer from treatment failure due to 5-Fu resistance. Emerging observations revealed the important role of chemokine (C-X-C motif) ligand 13 (CXCL-13) in tumor microenvironment and its relationship with prognosis in patients with colorectal cancer. This study is designed to reveal the important role of CXCL-13 in causing colorectal cancer resistance to 5-Fu.
Materials and Methods
CXCL-13 levels of patient's serum or cell culture supernatants were measured separately by enzyme-linked immunosorbent assay. In cell assays, cell viability is detected by Cell Counting Kit-8. Therefore, the recombinant human CXCL-13 was used to simulate its high expression in cells while its antibody and siRNA were used to reduce CXCL-13 expression in cells.
Results
In this study, we demonstrated that CXCL-13 is associated with 5-Fu resistance by culture medium exchange experiments and cytokine arrays of colorectal cancer resistant and nonresistant cells. Clinical studies showed that CXCL-13 is highly expressed in the serum of 5-Fu–resistant patients. High levels of serum CXCL-13 also predict a worse clinical outcome. The addition of recombinant CXCL-13 cytokine resulted in 5-Fu resistance, while its antibody overcame 5-Fu resistance, and knockdown of CXCL-13 expression by siRNA also reduced 5-Fu resistance, which can be saved by added recombination CXCL-13.
Conclusion
These results not only identify a CXCL-13 mediated 5-Fu resistance mechanism but also provide a novel target for 5-Fu–resistant colorectal cancer in prevention and treatment strategies. -
Citations
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Asian Journal of Pharmaceutical Sciences.2022; 17(3): 385. CrossRef - Potential Role of CXCL13/CXCR5 Signaling in Immune Checkpoint Inhibitor Treatment in Cancer
Ching-Hung Hsieh, Cheng-Zhe Jian, Liang-In Lin, Guan-Sian Low, Ping-Yun Ou, Chiun Hsu, Da-Liang Ou
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Xiaonan Zhou, Shizhu Guo, Yonghong Shi
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Haili Wu, Jin’e Du, Chenglu Li, Hanqing Li, Huiqin Guo, Zhuoyu Li
International Journal of Molecular Sciences.2022; 23(7): 3544. CrossRef - Chemokines and chemokine receptors in colorectal cancer; multifarious roles and clinical impact
Maria Braoudaki, Mohammed Saqif Ahmad, Denis Mustafov, Sara Seriah, Mohammad Naseem Siddiqui, Shoib Sarwar Siddiqui
Seminars in Cancer Biology.2022; 86: 436. CrossRef - Bioinformatics Analysis of Prognostic Significance and Immune Characteristics of CXC Chemokine Family in Patients with Lung Adenocarcinoma
Dachen Bian, Yanhua Chen, Ahmed Faeq Hussein
Computational and Mathematical Methods in Medicine.2022; 2022: 1. CrossRef - Chemokines in progression, chemoresistance, diagnosis, and prognosis of colorectal cancer
Qian Zou, Xue Lei, Aijing Xu, Ziqi Li, Qinglian He, Xiujuan Huang, Guangxian Xu, Faqing Tian, Yuanlin Ding, Wei Zhu
Frontiers in Immunology.2022;[Epub] CrossRef - CXCL13-CXCR5 axis: Regulation in inflammatory diseases and cancer
Binhan Wang, Manni Wang, Danyi Ao, Xiawei Wei
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2022; 1877(5): 188799. CrossRef - A novel oxidative stress- and ferroptosis-related gene prognostic signature for distinguishing cold and hot tumors in colorectal cancer
Xu Wang, Yuanmin Xu, Longfei Dai, Zhen Yu, Ming Wang, Shixin Chan, Rui Sun, Qijun Han, Jiajie Chen, Xiaomin Zuo, Zhenglin Wang, Xianyu Hu, Yang Yang, Hu Zhao, Kongwang Hu, Huabing Zhang, Wei Chen
Frontiers in Immunology.2022;[Epub] CrossRef - Identification of necroptosis-related subtypes, development of a novel signature, and characterization of immune infiltration in colorectal cancer
Mengyu Sun, Xiaoyu Ji, Meng Xie, Xiaoping Chen, Bixiang Zhang, Xiangyuan Luo, Yangyang Feng, Danfei Liu, Yijun Wang, Yiwei Li, Bifeng Liu, Limin Xia, Wenjie Huang
Frontiers in Immunology.2022;[Epub] CrossRef - Recent Updates on Mechanisms of Resistance to 5-Fluorouracil and Reversal Strategies in Colon Cancer Treatment
Shamin Azwar, Heng Fong Seow, Maha Abdullah, Mohd Faisal Jabar, Norhafizah Mohtarrudin
Biology.2021; 10(9): 854. CrossRef - CXCL2-mediated ATR/CHK1 signaling pathway and platinum resistance in epithelial ovarian cancer
Sipei Nie, Yicong Wan, Hui Wang, Jinhui Liu, Jing Yang, Rui Sun, Huangyang Meng, Xiaolin Ma, Yi Jiang, Wenjun Cheng
Journal of Ovarian Research.2021;[Epub] CrossRef - The CXCL Family Contributes to Immunosuppressive Microenvironment in Gliomas and Assists in Gliomas Chemotherapy
Zeyu Wang, Yuze Liu, Yuyao Mo, Hao Zhang, Ziyu Dai, Xun Zhang, Weijie Ye, Hui Cao, Zhixiong Liu, Quan Cheng
Frontiers in Immunology.2021;[Epub] CrossRef - Multifaceted roles of CCL20 (C-C motif chemokine ligand 20): mechanisms and communication networks in breast cancer progression
Louis Boafo Kwantwi, Shujing Wang, Youjing Sheng, Qiang Wu
Bioengineered.2021; 12(1): 6923. CrossRef - CXCL13 in Cancer and Other Diseases: Biological Functions, Clinical Significance, and Therapeutic Opportunities
San-Hui Gao, Sheng-Zhi Liu, Gui-Zhen Wang, Guang-Biao Zhou
Life.2021; 11(12): 1282. CrossRef - Therapeutic Influence on Important Targets Associated with Chronic Inflammation and Oxidative Stress in Cancer Treatment
Margarita Neganova, Junqi Liu, Yulia Aleksandrova, Sergey Klochkov, Ruitai Fan
Cancers.2021; 13(23): 6062. CrossRef - Chemoresistance Mechanisms in Colon Cancer: Focus on Conventional Chemotherapy
Klara Mladenić , Mirela Sedić
Clinical Cancer Drugs.2021; 8(2): 67. CrossRef
- Nucleotide metabolism-associated drug resistance gene NDUFA4L2 promotes colon cancer progression and 5-FU resistance
- 12,664 View
- 347 Download
- 30 Web of Science
- 29 Crossref
- Clinical Impact of Somatic Variants in Homologous Recombination Repair-Related Genes in Ovarian High-Grade Serous Carcinoma
- Min Chul Choi, Sohyun Hwang, Sewha Kim, Sang Geun Jung, Hyun Park, Won Duk Joo, Seung Hun Song, Chan Lee, Tae-Heon Kim, Haeyoun Kang, Hee Jung An
- Cancer Res Treat. 2020;52(2):634-644. Published online January 6, 2020
- DOI: https://doi.org/10.4143/crt.2019.207
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
In this study, we investigated the frequencies of mutations in DNA damage repair genes including BRCA1, BRCA2, homologous recombination genes and TP53 gene in ovarian high-grade serous carcinoma, alongside those of germline and somatic BRCA mutations, with the aim of improving the identification of patients suitable for treatment with poly(ADP-ribose) polymerase inhibitors.
Materials and Methods
Tissue samples from 77 Korean patients with ovarian high-grade serous carcinoma were subjected to next-generation sequencing. Pathogenic alterations of 38 DNA damage repair genes and TP53 gene and their relationships with patient survival were examined. Additionally, we analyzed BRCA germline variants in blood samples from 47 of the patients for comparison.
Results
BRCA1, BRCA2, and TP53 mutations were detected in 28.6%, 5.2%, and 80.5% of the 77 patients, respectively. Alterations in RAD50, ATR, MSH6, MSH2, and FANCA were also identified. At least one mutation in a DNA damage repair gene was detected in 40.3% of patients (31/77). Germline and somatic BRCA mutations were found in 20 of 47 patients (42.6%), and four patients had only somatic mutations without germline mutations (8.5%, 4/47). Patients with DNA damage repair gene alterations with or without TP53mutation, exhibited better disease-free survival than those with TP53 mutation alone.
Conclusion
DNA damage repair genes were mutated in 40.3% of patients with high-grade serous carcinoma, with somatic BRCA mutations in the absence of germline mutation in 8.5%. Somatic variant examination, along with germline testing of DNA damage repair genes, has potential to detect additional candidates for PARP inhibitor treatment. -
Citations
Citations to this article as recorded by- Genomic instability in ovarian cancer: Through the lens of single nucleotide polymorphisms
Harshavardhani Canchi Sistla, Srikanth Talluri, Taruna Rajagopal, Sivaramakrishnan Venkatabalasubramanian, Nageswara Rao Dunna
Clinica Chimica Acta.2025; 565: 119992. CrossRef - BRCA1, BRCA2, and TP53 germline and somatic variants and clinicopathological characteristics of Brazilian patients with epithelial ovarian cancer
Caroline Stahnke Richau, Nicole de Miranda Scherer, Bruna Palma Matta, Elvismary Molina de Armas, Fábio Carvalho de Barros Moreira, Anke Bergmann, Claudia Bessa Pereira Chaves, Mariana Boroni, Anna Claudia Evangelista dos Santos, Miguel Angelo Martins Mor
Cancer Medicine.2024;[Epub] CrossRef - Proteomic landscape of epithelial ovarian cancer
Liujia Qian, Jianqing Zhu, Zhangzhi Xue, Yan Zhou, Nan Xiang, Hong Xu, Rui Sun, Wangang Gong, Xue Cai, Lu Sun, Weigang Ge, Yufeng Liu, Ying Su, Wangmin Lin, Yuecheng Zhan, Junjian Wang, Shuang Song, Xiao Yi, Maowei Ni, Yi Zhu, Yuejin Hua, Zhiguo Zheng, Ti
Nature Communications.2024;[Epub] CrossRef - T-Cell Receptor Repertoire Characteristics Associated with Prognostic Significance in High-Grade Serous Ovarian Carcinoma
Ju-Won Kim, Sewha Kim, So-Yun Yang, Je-Gun Joung, Sohyun Hwang
Genes.2023; 14(4): 785. CrossRef - Potential prognostic role of somatic mutations in a set of cancer susceptibility genes in ovarian carcinoma: A follow-up multicentric study from Pakistan
Atika Masood, Rahat Sarfaraz, Saima Zaki, Amira Shami, Saba Khaliq, Nadia Naseem
Cancer Biomarkers.2023; 36(3): 207. CrossRef - Deleterious and ethnic-related BRCA1/2 mutations in tissue and blood of Egyptian colorectal cancer patients and its correlation with human papillomavirus
Amira Salah El-Din Youssef, Abdel Rahman N. Zekri, Marwa Mohanad, Samah A. Loutfy, Nasra F. Abdel Fattah, Mostafa H. Elberry, Asmaa A. El Leithy, Ahmed El-Touny, Ahmed Samy Rabie, Mohamed Shalaby, Ayman Hanafy, Mai M. Lotfy, Enas R. El-sisi, Gharieb S. El
Clinical and Experimental Medicine.2023; 23(8): 5063. CrossRef - SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA‐deficient cells
Ka‐Kui Chan, Zahi Abdul‐Sater, Aditya Sheth, Dana K. Mitchell, Richa Sharma, Donna M. Edwards, Ying He, Grzegorz Nalepa, Steven D. Rhodes, D. Wade Clapp, Elizabeth A. Sierra Potchanant
Molecular Oncology.2022; 16(4): 860. CrossRef - Somatic genomic landscape of East Asian epithelial ovarian carcinoma and its clinical implications from prospective clinical sequencing: A Korean Gynecologic Oncology Group study (KGOG 3047)
Jason K. Sa, Jihye Kim, Sokbom Kang, Sang Wun Kim, Taejong Song, Seung‐Hyuk Shim, Min Chul Choi, Jae Hong No, Jae‐Yun Song, Deokhoon Kim, Yong‐Man Kim, Jae‐Hoon Kim, Jeong‐Won Lee
International Journal of Cancer.2022; 151(7): 1086. CrossRef - Analysis of Novel Variants Associated with Three Human Ovarian Cancer
Cell Lines
Venugopala Reddy Mekala, Jan-Gowth Chang, Ka-Lok Ng
Current Bioinformatics.2022; 17(4): 380. CrossRef - Genomic profiling of platinum-resistant ovarian cancer: The road into druggable targets
Alexandre André Balieiro Anastácio da Costa, Glauco Baiocchi
Seminars in Cancer Biology.2021; 77: 29. CrossRef - The Prognostic and Predictive Role of Somatic BRCA Mutations in Ovarian Cancer: Results from a Multicenter Cohort Study
Angela Toss, Claudia Piombino, Elena Tenedini, Alessandra Bologna, Elisa Gasparini, Vittoria Tarantino, Maria Elisabetta Filieri, Luca Cottafavi, Filippo Giovanardi, Stefano Madrigali, Monica Civallero, Luigi Marcheselli, Isabella Marchi, Federica Domati,
Diagnostics.2021; 11(3): 565. CrossRef - USP19 and RPL23 as Candidate Prognostic Markers for Advanced-Stage High-Grade Serous Ovarian Carcinoma
Haeyoun Kang, Min Chul Choi, Sewha Kim, Ju-Yeon Jeong, Ah-Young Kwon, Tae-Hoen Kim, Gwangil Kim, Won Duk Joo, Hyun Park, Chan Lee, Seung Hun Song, Sang Geun Jung, Sohyun Hwang, Hee Jung An
Cancers.2021; 13(16): 3976. CrossRef - Summary of BARD1 Mutations and Precise Estimation of Breast and Ovarian Cancer Risks Associated with the Mutations
Malwina Suszynska, Piotr Kozlowski
Genes.2020; 11(7): 798. CrossRef - Prevalence of pathogenic variants in actionable genes in advanced ovarian cancer: a next-generation sequencing analysis of a nationwide registry study
Sokbom Kang, Ye L. Yu, Soo Y. Cho, Seog-Yun Park
European Journal of Cancer.2020; 141: 185. CrossRef - PARP Inhibition Increases the Reliance on ATR/CHK1 Checkpoint Signaling Leading to Synthetic Lethality—An Alternative Treatment Strategy for Epithelial Ovarian Cancer Cells Independent from HR Effectiveness
Patrycja Gralewska, Arkadiusz Gajek, Agnieszka Marczak, Michał Mikuła, Jerzy Ostrowski, Agnieszka Śliwińska, Aneta Rogalska
International Journal of Molecular Sciences.2020; 21(24): 9715. CrossRef
- Genomic instability in ovarian cancer: Through the lens of single nucleotide polymorphisms
- 10,683 View
- 295 Download
- 15 Web of Science
- 15 Crossref
- Impact of Angiotensin Receptor Blockers, Beta Blockers, Calcium Channel Blockers and Thiazide Diuretics on Survival of Ovarian Cancer Patients
- Min Ae Cho, Soo Young Jeong, Insuk Sohn, Myeong-Seon Kim, Jun Hyeok Kang, E Sun Paik, Yoo-Young Lee, Chel Hun Choi
- Cancer Res Treat. 2020;52(2):645-654. Published online January 16, 2020
- DOI: https://doi.org/10.4143/crt.2019.509
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
We investigated the impact of four types of antihypertensive medications, angiotensin receptor blockers (ARBs), beta blockers (BBs; both selective and non-selective), calcium channel blockers (CCBs), and thiazide diuretics (TDs) on survival outcomes in epithelial ovarian cancer (EOC).
Materials and Methods
A single-institutional retrospective chart review of 878 patients with EOC was performed. Survival was compared according to use of the four antihypertensive medications during primary treatment. Propensity score matching (ratio 1:3) was performed to control possible associated covariates, such as age, International Federation of Gynecology and Obstetrics stage, residual status after primary debulking surgery, and co-morbidity.
Results
Among 878 patients, 56 patients (6.4%) were ARB users, 62 (7.1%) were BB users, 107 (12.2%) were CCBs users and 32 (3.6%) used TDs. Median progression-free survival (PFS) for ARB, BB, and CCB users was 37.8, 27.2, and 23.6 months compared with 33.6 months for non-users. ARB was associated with 35% decreased risk of disease progression (hazard ratio [HR], 0.65; 95% confidence interval [CI], 0.42 to 0.99; p=0.046) in multivariate analysis. After propensity score matching, median PFS for ARB users was 37.8 months and ARB use remained to be associated with lower recurrence rate in univariate (p=0.035) and multivariate analysis (HR, 0.60; 95% CI, 0.39 to 0.93; p=0.022).
Conclusion
In this study, ARBs use during primary treatment is associated with lower recurrence in EOC patients. However, CCBs, BBs, and TDs did not show beneficial impact. -
Citations
Citations to this article as recorded by- Evaluation of antihypertensive medications use and survival in patients with ovarian cancer: a population-based retrospective cohort study
Rūta Everatt, Irena Kuzmickienė, Birutė Brasiūnienė, Ieva Vincerževskienė, Birutė Intaitė, Saulius Cicėnas, Ingrida Lisauskienė
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Nhi Thi Hong Nguyen, Phung-Anh Nguyen, Chih-Wei Huang, Ching-Huan Wang, Ming-Chin Lin, Min-Huei Hsu, Hoang Bui Bao, Shuo-Chen Chien, Hsuan-Chia Yang
International Journal of Molecular Sciences.2023; 24(4): 3814. CrossRef - Association of Hypertension and Breast Cancer: Antihypertensive Drugs as an Effective Adjunctive in Breast Cancer Therapy
Yuanyuan Fan, Nazeer Hussain Khan, Muhammad Farhan Ali Khan, MD Faysal Ahammad, Tayyaba Zulfiqar, Razia Virk, Enshe Jiang
Cancer Management and Research.2022; Volume 14: 1323. CrossRef - The effect of angiotensin receptor blockers and angiotensin-converting enzyme inhibitors on progression of gastric cancer: systematic review and meta-analysis
Seyed Ali Mehrdad, Farshad Mirzavi, Seyed Mohammad Reza Seyedi, Ahmad Asoodeh
Anti-Cancer Drugs.2022; 33(10): 983. CrossRef - Repurposing approved drugs for cancer therapy
Catherine H Schein
British Medical Bulletin.2021; 137(1): 13. CrossRef - Norepinephrine inhibits migration and invasion of human glioblastoma cell cultures possibly via MMP-11 inhibition
Jing Zhong, Weiran Shan, Zhiyi Zuo
Brain Research.2021; 1756: 147280. CrossRef - Antihypertensive Drug Use and the Risk of Ovarian Cancer Death among Finnish Ovarian Cancer Patients—A Nationwide Cohort Study
Eerik E. E. Santala, Miia Artama, Eero Pukkala, Kala Visvanathan, Synnöve Staff, Teemu J. Murtola
Cancers.2021; 13(9): 2087. CrossRef - The Use of Antihypertensive Drugs as Coadjuvant Therapy in Cancer
José A. Carlos-Escalante, Marcela de Jesús-Sánchez, Alejandro Rivas-Castro, Pavel S. Pichardo-Rojas, Claudia Arce, Talia Wegman-Ostrosky
Frontiers in Oncology.2021;[Epub] CrossRef - Post-Diagnostic Beta Blocker Use and Prognosis of Ovarian Cancer: A Systematic Review and Meta-Analysis of 11 Cohort Studies With 20,274 Patients
Zhao-Yan Wen, Song Gao, Ting-Ting Gong, Yu-Ting Jiang, Jia-Yu Zhang, Yu-Hong Zhao, Qi-Jun Wu
Frontiers in Oncology.2021;[Epub] CrossRef - Stress Hormones: Emerging Targets in Gynecological Cancers
Guoqiang Chen, Lei Qiu, Jinghai Gao, Jing Wang, Jianhong Dang, Lingling Li, Zhijun Jin, Xiaojun Liu
Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef - The Effect of Local Renin Angiotensin System in the Common Types of Cancer
Moudhi Almutlaq, Abir Abdullah Alamro, Hassan S. Alamri, Amani Ahmed Alghamdi, Tlili Barhoumi
Frontiers in Endocrinology.2021;[Epub] CrossRef - Does sympathetic nervous system modulate tumor progression? A narrative review of the literature
Ioannis Stavropoulos, Angelos Sarantopoulos, Anastasios Liverezas
Journal of Drug Assessment.2020; 9(1): 106. CrossRef
- Evaluation of antihypertensive medications use and survival in patients with ovarian cancer: a population-based retrospective cohort study
- 14,262 View
- 163 Download
- 18 Web of Science
- 14 Crossref
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