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- Volume 51(2); April 2019
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Obituary
- In Memoriam: Waun Ki Hong, M.D. (August 13, 1942-January 2, 2019)
- Hoon-Kyo Kim
- Cancer Res Treat. 2019;51(2):415-416. Published online March 18, 2019
- DOI: https://doi.org/10.4143/crt.2019.149
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- Waun Ki Hong, MD, D.M.Sc (Hon) (1942–2019): A Mentor Who Left Behind a Legacy for Generations to Come
Hyun Cheol Chung
Yonsei Medical Journal.2020; 61(7): 557. CrossRef
- Waun Ki Hong, MD, D.M.Sc (Hon) (1942–2019): A Mentor Who Left Behind a Legacy for Generations to Come
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Special Articles
- Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2016
- Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Eun Sook Lee, The Community of Population-Based Regional Cancer Registries
- Cancer Res Treat. 2019;51(2):417-430. Published online March 18, 2019
- DOI: https://doi.org/10.4143/crt.2019.138
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Abstract
PDFPubReaderePub - Purpose
This study presents the 2016 nationwide cancer statistics in Korea, including cancer incidence, survival, prevalence, and mortality.
Materials and Methods
Cancer incidence data from 1999 to 2016 were obtained from the Korea National Cancer Incidence Database and followed until December 31, 2017. Mortality data from 1983 to 2016 were obtained from Statistics Korea. The prevalence was defined as the number of cancer patients alive on January 1, 2017 among all cancer patients diagnosed since 1999. Crude and age-standardized rates (ASRs) for incidence, mortality, and prevalence and 5-year relative survivals were also calculated.
Results
Overall, 229,180 and 78,194 Koreans were newly diagnosed and died from cancer in 2016, respectively. The ASRs for cancer incidence and mortality in 2016 were 269.0 and 79.8 per 100,000 individuals, respectively. The all-cancer incidence rate increased significantly by 3.6% annually from 1999 to 2011 and started to decrease after 2011 (2011-2016; annual percent change, –3.1%). However, overall cancer mortality has decreased 2.7% annually since 2002. The 5-year relative survival rate for patients diagnosed with cancer between 2012 and 2016 was 70.6%, an improvement from the 41.2% for patients diagnosed between 1993 and 1995.
Conclusion
The cancer prevalence in Korea has increased very fast as survival has improved remarkably. The high prevalence of cancer emphasizes the need for comprehensive cancer control efforts in Korea. -
Citations
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Kyung-In Joung, Jong Hwa Song, Kangho Suh, Seung-Mi Lee, Ji Hyun Jun, Taehwan Park, Dong Churl Suh
BioDrugs.2021; 35(1): 61. CrossRef - Trends in Pediatric Thyroid Cancer Incidence, Treatment, and Clinical Course in Korea During 2004–2016: A Nationwide Population-Based Study
Young Ah Lee, Hyo Ri Yun, Juneyoung Lee, Hyemi Moon, Choong Ho Shin, Sin Gon Kim, Young Joo Park
Thyroid.2021; 31(6): 902. CrossRef - Differences in Dietary Patterns Identified by the Gaussian Graphical Model in Korean Adults With and Without a Self-Reported Cancer Diagnosis
Tung Hoang, Jeonghee Lee, Jeongseon Kim
Journal of the Academy of Nutrition and Dietetics.2021; 121(8): 1484. CrossRef - Physical and Mental Health Factors Associated with Poor Nutrition in Elderly Cancer Survivors: Insights from a Nationwide Survey
Mikyong Byun, Eunjung Kim, Jieun Kim
International Journal of Environmental Research and Public Health.2021; 18(17): 9313. CrossRef - Therapeutic Decision Making in Hepatocellular Carcinoma According to Age and Child–Pugh Class: A Nationwide Cohort Analysis in South Korea
Sunmin Park, Chai Hong Rim, Young Kul Jung, Won Sup Yoon, Alessandro Granito
Canadian Journal of Gastroenterology and Hepatology.2021; 2021: 1. CrossRef - Association of Aspirin, Metformin, and Statin Use with Gastric Cancer Incidence and Mortality: A Nationwide Cohort Study
Mi Hee Cho, Tae Gon Yoo, Su-Min Jeong, Dong Wook Shin
Cancer Prevention Research.2021; 14(1): 95. CrossRef - Multivariate analysis of early surgical management factors affecting posttraumatic penoscrotal avulsion injury: a level I trauma center study
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BMC Urology.2021;[Epub] CrossRef - Serum concentrations of persistent organic pollutants and colorectal cancer risk: A case-cohort study within Korean National Cancer Center Community (KNCCC) cohort
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Chemosphere.2021; 271: 129596. CrossRef - Association between changes in mammographic density category and the risk of breast cancer: A nationwide cohort study in East‐Asian women
Soyeoun Kim, Boyoung Park
International Journal of Cancer.2021; 148(11): 2674. CrossRef - Prospective evaluation of metabolic intratumoral heterogeneity in patients with advanced gastric cancer receiving palliative chemotherapy
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Scientific Reports.2021;[Epub] CrossRef - Clinical Application of Targeted Deep Sequencing in Metastatic Colorectal Cancer Patients: Actionable Genomic Alteration in K-MASTER Project
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Cancer Research and Treatment.2021; 53(1): 123. CrossRef - Adherence to the Recommended Intake of Calcium and Colorectal Cancer Risk in the HEXA Study
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Cancer Research and Treatment.2021; 53(1): 140. CrossRef - Characterizing the Anticancer Treatment Trajectory and Pattern in Patients Receiving Chemotherapy for Cancer Using Harmonized Observational Databases: Retrospective Study
Hokyun Jeon, Seng Chan You, Seok Yun Kang, Seung In Seo, Jeremy L Warner, Rimma Belenkaya, Rae Woong Park
JMIR Medical Informatics.2021; 9(4): e25035. CrossRef - A Nationwide, Population-Based Epidemiology Study of Primary Central Nervous System Tumors in Korea, 2007-2016: A Comparison with United States Data
Ho Kang, Sang Woo Song, Johyun Ha, Young-Joo Won, Chul-Kee Park, Heon Yoo, Kyu-Won Jung
Cancer Research and Treatment.2021; 53(2): 355. CrossRef - Anterolateral thigh free flaps and radial forearm free flaps in head and neck reconstruction: A 20-year analysis from a single institution
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Archives of Plastic Surgery.2021; 48(01): 49. CrossRef - Time trends of colorectal cancer incidence and associated lifestyle factors in South Korea
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Scientific Reports.2021;[Epub] CrossRef - Characteristics and Prognostic Factors of Recurrence after Hemithyroidectomy in Patients with Papillary Thyroid Microcarcinoma
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Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2021; 64(1): 19. CrossRef - Automated detection of colorectal tumors based on artificial intelligence
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BMC Medical Informatics and Decision Making.2021;[Epub] CrossRef - Development of Korean CARcinogen EXposure: An Initiative of the Occupational Carcinogen Surveillance System in Korea
Dong-Hee Koh, Ju-Hyun Park, Sang-Gil Lee, Hwan-Cheol Kim, Sangjun Choi, Hyejung Jung, Inah Kim, Donguk Park
Annals of Work Exposures and Health.2021; 65(5): 528. CrossRef - Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
Hyuna Sung, Jacques Ferlay, Rebecca L. Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie Bray
CA: A Cancer Journal for Clinicians.2021; 71(3): 209. CrossRef - The emergence of oral cavity cancer and the stabilization of oropharyngeal cancer: Recent contrasting epidemics in the South Korean population
Yuh‐Seog Jung, Jungirl Seok, Seri Hong, Chang Hwan Ryu, Junsun Ryu, Kyu‐Won Jung
Cancer.2021; 127(10): 1638. CrossRef - Bioengineered gold nanoparticles using Cynodon dactylon extract and its cytotoxicity and antibacterial activities
Ramachandran Vinayagam, Murali Santhoshkumar, Kyung Eun Lee, Ernest David, Sang Gu Kang
Bioprocess and Biosystems Engineering.2021; 44(6): 1253. CrossRef - The role of gonadotropin-releasing hormone agonists in female fertility preservation
Jae Hoon Lee, Young Sik Choi
Clinical and Experimental Reproductive Medicine.2021; 48(1): 11. CrossRef - Surtuin 1 as a potential prognostic biomarker in very elderly patients with colorectal cancer
Guk Jin Lee, Yun Hwa Jung, Tae-Jung Kim, Yosep Chong, Seo-Won Jeong, In Kyu Lee, In Sook Woo
The Korean Journal of Internal Medicine.2021; 36(Suppl 1): S235. CrossRef - Risk factors of advanced metachronous neoplasms in surveillance after colon cancer resection
Kwangwoo Nam, Jeong Eun Shin
The Korean Journal of Internal Medicine.2021; 36(2): 305. CrossRef - CDX-2 Protein and mRNA Expression in Canine Intestinal Adenocarcinoma
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Journal of Comparative Pathology.2021; 184: 24. CrossRef - Characteristics of interval gastric neoplasms detected within two years after negative screening endoscopy among Koreans
Joo Hyun Lim, Ji Hyun Song, Su Jin Chung, Goh Eun Chung, Joo Sung Kim
BMC Cancer.2021;[Epub] CrossRef - Metformin use in cancer survivors with diabetes reduces all-cause mortality, based on the Korean National Health Insurance Service between 2002 and 2015
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Medicine.2021; 100(11): e25045. CrossRef - Serum Testosterone Level as Possible Predictive Marker for Prognosis in Metastatic Castration-Resistant Prostate Cancer Patients Treated With Enzalutamide
Dong Hyeon An, Hwiwoo Kim, Donghyun Lee, In Gab Jeong, Dalsan You, Jun Hyuk Hong, Choung-Soo Kim, Hanjong Ahn
The Korean Journal of Urological Oncology.2021; 19(1): 60. CrossRef - Periodic Fluctuations in the Incidence of Gastrointestinal Cancer
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Frontiers in Oncology.2021;[Epub] CrossRef - Recent Trends of Lung Cancer in Korea
Jae Guk Lee, Ho Cheol Kim, Chang-Min Choi
Tuberculosis and Respiratory Diseases.2021; 84(2): 89. CrossRef - The Perspective of Therapeutic Antibody Marketing in Iran: Trend and Estimation by 2025
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Advances in Pharmacological and Pharmaceutical Sciences.2021; 2021: 1. CrossRef - De Novo Cancer Incidence after Cholecystectomy in Korean Population
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Journal of Clinical Medicine.2021; 10(7): 1445. CrossRef - Radiologic Evaluation for Resectability of Pancreatic Adenocarcinoma
Shin Hye Hwang, Mi-Suk Park
Journal of the Korean Society of Radiology.2021; 82(2): 315. CrossRef - Trends in Cancer Screening Rates among Korean Men and Women: Results of the Korean National Cancer Screening Survey, 2004–2018
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Cancer Research and Treatment.2021; 53(2): 330. CrossRef - A Modular Mobile Health App for Personalized Rehabilitation Throughout the Breast Cancer Care Continuum: Development Study
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JMIR Formative Research.2021; 5(4): e23304. CrossRef - Real-World Clinical Data of Palbociclib in Asian Metastatic Breast Cancer Patients: Experiences from Eight Institutions
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Cancer Research and Treatment.2021; 53(2): 409. CrossRef - Association between cancer stigma and job loss among cancer survivors
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British Journal of Cancer.2021; 125(1): 119. CrossRef - Implications of Radiotherapy Utilization in Korea from 2010 to 2019
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Frontiers in Oncology.2021;[Epub] CrossRef - Analyses of the Association between Thyroid Cancer and Osteoporosis/Fracture Histories: A Cross-Sectional Study Using KoGES HEXA Data
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International Journal of Environmental Research and Public Health.2021; 18(9): 4732. CrossRef - Association between long-term exposure to high levels of ambient air pollution and incidence of lung cancer in a population-based cohort
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Environmental Research.2021; 198: 111214. CrossRef - Real‐world utility of next‐generation sequencing for targeted gene analysis and its application to treatment in lung adenocarcinoma
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Cancer Medicine.2021; 10(10): 3197. CrossRef - The Impact of Primary Tumor Resection on Survival in Asymptomatic Colorectal Cancer Patients With Unresectable Metastases
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Annals of Coloproctology.2021; 37(2): 94. CrossRef - Decreasing trends in thyroid cancer incidence in South Korea: What happened in South Korea?
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Cancer Medicine.2021; 10(12): 4087. CrossRef - Trends in Childhood Thyroid Cancer incidence in Korea and Its Potential Risk Factors
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Frontiers in Endocrinology.2021;[Epub] CrossRef - Disparities in prostate cancer diagnosis, treatment, and survival among men with disabilities: Retrospective cohort study in South Korea
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Disability and Health Journal.2021; 14(4): 101125. CrossRef - Emerging treatments for bacillus Calmette–Guérin-unresponsive non-muscle-invasive bladder cancer
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Investigative and Clinical Urology.2021; 62(4): 361. CrossRef - Study on effects of miR-141-3p in proliferation, migration, invasion and apoptosis of colon cancer cells by inhibiting Bcl2
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Clinical and Translational Oncology.2021; 23(12): 2526. CrossRef - Association between gallstones and the risk of biliary tract cancer: a systematic review and meta-analysis
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Epidemiology and Health.2021; 43: e2021011. CrossRef - The impact of expanding health insurance coverage for anti‐cancer drugs on cancer survival in Korea
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Cancer Medicine.2021; 10(13): 4555. CrossRef - Analyses of the association between breast cancer and osteoporosis/fracture history: a cross-sectional study using KoGES HEXA data
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Archives of Osteoporosis.2021;[Epub] CrossRef - Efficacy of Intraoperative Neuromonitoring during Thyroidectomy with Transcutaneous Adhesive Skin Electrodes
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Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2021; 64(6): 416. CrossRef - Individual 5-Year Lung Cancer Risk Prediction Model in Korea Using a Nationwide Representative Database
Yohwan Yeo, Dong Wook Shin, Kyungdo Han, Sang Hyun Park, Keun-Hye Jeon, Jungkwon Lee, Junghyun Kim, Aesun Shin
Cancers.2021; 13(14): 3496. CrossRef - Genetic Susceptibility of ACE2 and TMPRSS2 in Six Common Cancers and Possible Impacts on COVID-19
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Cancer Research and Treatment.2021; 53(3): 650. CrossRef - Population Attributable Fraction of Helicobacter pylori Infection–Related Gastric Cancer in Korea: A Meta-Analysis
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Cancer Research and Treatment.2021; 53(3): 744. CrossRef - Application Research of Individualized Conditional Reprogramming System to Guide Treatment of Gastric Cancer
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Frontiers in Oncology.2021;[Epub] CrossRef - Fear of cancer recurrence in Korean women after breast cancer treatment: A mixed methods study
Se Jin Hong, Nah-Mee Shin
European Journal of Oncology Nursing.2021; 54: 102010. CrossRef - The Association between the Use of Dietary Supplement and Psychological Status of Cancer Survivors in Korea: A Cross-Sectional Study
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Korean Journal of Family Medicine.2021; 42(4): 317. CrossRef - Disparities in Cancer-Related Avoidable Mortality by the Level of Area Deprivation in South Korea
Woorim Kim, Seongkyeong Jang, Gangeun Lee, Yoon Jung Chang
International Journal of Environmental Research and Public Health.2021; 18(15): 7856. CrossRef - Validity and reliability of the Health-Related Quality of Life Instrument with 8 Items (HINT-8) in Korean breast cancer patients
Juyoung Kim, Min-Woo Jo, Hyeon-Jeong Lee, Sei-Hyun Ahn, Byung Ho Son, Jong Won Lee, Sae Byul Lee
Osong Public Health and Research Perspectives.2021; 12(4): 254. CrossRef - Risk of Cancer in Middle-aged Patients With Gout: A Nationwide Population-based Study in Korea
Jung Sun Lee, Jisun Myung, Hyun Ah Lee, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Ji Seon Oh, Yong-Gil Kim
The Journal of Rheumatology.2021; 48(9): 1465. CrossRef - Usage of Platinum Nanoparticles for Anticancer Therapy over Last Decade: A Review
Aditya Amrut Pawar, Jyotirmayee Sahoo, Aakash Verma, Abhijit Lodh, Jaya Lakkakula
Particle & Particle Systems Characterization.2021;[Epub] CrossRef - The incidence and survival of cervical, ovarian, and endometrial cancer in Korea, 1999-2017: Korea Central Cancer Registry
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Obstetrics & Gynecology Science.2021; 64(5): 444. CrossRef - Bacteria-Derived Extracellular Vesicles in Urine as a Novel Biomarker for Gastric Cancer: Integration of Liquid Biopsy and Metagenome Analysis
Jae-Yong Park, Chil-Sung Kang, Ho-Chan Seo, Jin-Chul Shin, Sung-Min Kym, Young-Soo Park, Tae-Seop Shin, Jae-Gyu Kim, Yoon-Keun Kim
Cancers.2021; 13(18): 4687. CrossRef - Physical Activity after Colorectal Cancer Diagnosis and Mortality in a Nationwide Retrospective Cohort Study
Meesun Lee, Yunseo Lee, Doeun Jang, Aesun Shin
Cancers.2021; 13(19): 4804. CrossRef - Development of Population-Based Cancer Indicators and a Measurement of Cancer Care Continuum Using a Modified Delphi Method
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Cancers.2021; 13(19): 4826. CrossRef - Comparison of Long-Term Efficacy in S-1 and Capecitabine With Oxaliplatin as Adjuvant Chemotherapy for Patients With Gastric Cancer After Curative Surgery: A Retrospective, Single-Center Observational Study
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Technology in Cancer Research & Treatment.2021;[Epub] CrossRef - Analysis of the Occurrence of Diseases Following Gastrectomy for Early Gastric Cancer: a Nationwide Claims Study
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Technology in Cancer Research & Treatment.2021;[Epub] CrossRef - The Role of Prostate Combination Biopsy Consisting of Targeted and Additional Systematic Biopsy
Chung Un Lee, Joongwon Choi, Si Hyun Sung, Jae Hoon Chung, Wan Song, Minyong Kang, Hyun Hwan Sung, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Hwang Gyun Jeon
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Tissue Engineering and Regenerative Medicine.2021; 19(2): 205. CrossRef - Physical Activity Interventions for Colorectal Cancer Survivors
Youjin Jung, Joohyun Chung, Heesook Son
Cancer Nursing.2021; 44(6): E414. CrossRef - New approach of prediction of recurrence in thyroid cancer patients using machine learning
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Medicine.2021; 100(42): e27493. CrossRef - Nonclinical Safety Pharmacology Study of the Herbal Product HAD-B1
Soo-Dam Kim, Jae-Ho Yang, Eun-Bin Kwag, Ji-Hye Park, So-Jung Park, Hwa-Seung Yoo, Francesca Mancianti
Evidence-Based Complementary and Alternative Medicine.2021; 2021: 1. CrossRef - Development and External Validation of Survival Prediction Model for Pancreatic Cancer Using Two Nationwide Databases: Surveillance, Epidemiology and End Results (SEER) and Korea Tumor Registry System-Biliary Pancreas (KOTUS-BP)
Jae Seung Kang, Lydia Mok, Jin Seok Heo, In Woong Han, Sang Hyun Shin, Yoo-Seok Yoon, Ho-Seong Han, Dae Wook Hwang, Jae Hoon Lee, Woo Jung Lee, Sang Jae Park, Joon Seong Park, Yonghoon Kim, Huisong Lee, Young-Dong Yu, Jae Do Yang, Seung Eun Lee, Il Young
Gut and Liver.2021; 15(6): 912. CrossRef - Impact of the different biliopancreatic limb length on diabetes and incretin hormone secretion following distal gastrectomy in gastric cancer patients
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Scientific Reports.2021;[Epub] CrossRef - ‘Trend in premature mortality from four major NCDs in Nanjing, China, 2007–2018’
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BMC Public Health.2021;[Epub] CrossRef - Supportive Care Needs and Health-Related Quality of Life of Esophageal Cancer Survivors
Eunju Choi, Soo H Kim, Young W Lee, Hwasoon Kim, Young M Shim, Genehee Lee, Deborah L Volker
Asia-Pacific Journal of Oncology Nursing.2021; 8(2): 164. CrossRef - The relationship between metabolic syndrome and the incidence of colorectal cancer
JungHyun Lee, Kun Sei Lee, Hyeongsu Kim, Hyoseon Jeong, Min-Jung Choi, Hai-Won Yoo, Tae-Hwa Han, Hyunjung Lee
Environmental Health and Preventive Medicine.2020;[Epub] CrossRef - Clinical utilization of radiation therapy in Korea, 2016
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Chang‐Mo Oh, Dahhay Lee, Hyun‐Joo Kong, Seokmin Lee, Young‐Joo Won, Kyu‐Won Jung, Hyunsoon Cho
Cancer Medicine.2020; 9(5): 1741. CrossRef - Comparison Study of Robotic Thyroidectomies Through a Bilateral Axillo-Breast Approach and a Transoral Approach
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Journal of Laparoendoscopic & Advanced Surgical Techniques.2020; 30(2): 175. CrossRef - Bridging the Gap between Evidence and Real-World Practice for Liver Cancer Screening in South Korea
Chang-Mo Oh
Gut and Liver.2020; 14(1): 5. CrossRef - Association Between Fatty Liver Index and Risk of Breast Cancer: A Nationwide Population-Based Study
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Clinical Breast Cancer.2020; 20(4): e450. CrossRef - Validity and reliability of a Korean version of the breast cancer survivors resilience scale
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Japan Journal of Nursing Science.2020;[Epub] CrossRef - Prognostic significance of body mass index and prognostic nutritional index in stage II/III gastric cancer
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European Journal of Surgical Oncology.2020; 46(4): 620. CrossRef - Prevalence and Clinicopathological Significance of MET Overexpression and Gene Amplification in Patients with Gallbladder Carcinoma
Yeseul Kim, Seong Sik Bang, Seungyun Jee, Sungeon Park, Su-Jin Shin, Kiseok Jang
Cancer Research and Treatment.2020; 52(2): 481. CrossRef - Combination versus single-agent as palliative chemotherapy for gastric cancer
Jin-Hyuk Choi, Yong Won Choi, Seok Yun Kang, Geum Sook Jeong, Hyun Woo Lee, Seong Hyun Jeong, Joon Seong Park, Mi Sun Ahn, Seung Soo Sheen
BMC Cancer.2020;[Epub] CrossRef - Fibroblast Growth Factor Receptor 1 (FGFR1) Amplification Detected by Droplet Digital Polymerase Chain Reaction (ddPCR) Is a Prognostic Factor in Colorectal Cancers
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Cancer Research and Treatment.2020; 52(1): 74. CrossRef - Parathyroid hormone is associated with prostate cancer
Won Tae Kim, Woo Jin Bang, Sung Pil Seo, Ho Won Kang, Young Joon Byun, Xuan-Mei Piao, Pildu Jeong, Kyung-Sub Shin, Song-Yi Choi, Ok-Jun Lee, Yong-June Kim, Sang Cheol Lee, Seok Joong Yun, Wun-Jae Kim
Prostate International.2020; 8(3): 116. CrossRef - Occupational Class and Cancer Survival in Korean Men: Follow-Up Study of Nation-Wide Working Population
Hye-Eun Lee, Masayoshi Zaitsu, Eun-A Kim, Ichiro Kawachi
International Journal of Environmental Research and Public Health.2020; 17(1): 303. CrossRef - Association of Screening by Thyroid Ultrasonography with Mortality in Thyroid Cancer: A Case–Control Study Using Data from Two National Surveys
Jae Kwan Jun, Soon-Young Hwang, Seri Hong, Mina Suh, Kui Son Choi, Kyu-Won Jung
Thyroid.2020; 30(3): 396. CrossRef - Acknowledging the Unsung Role of the Cancer Registry in Rare Cancers
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Annals of Coloproctology.2020; 36(1): 1. CrossRef - Female reproductive factors and the risk of lung cancer in postmenopausal women: a nationwide cohort study
Keun Hye Jeon, Dong Wook Shin, Kyungdo Han, Dahye Kim, Jung Eun Yoo, Su-Min Jeong, Jong ho Cho
British Journal of Cancer.2020; 122(9): 1417. CrossRef - Castration-Resistant Prostate Cancer Outcome Prediction Using Phased Long Short-Term Memory with Irregularly Sampled Serial Data
Jihwan Park, Mi Jung Rho, Hyong Woo Moon, Ji Youl Lee
Applied Sciences.2020; 10(6): 2000. CrossRef - Dietary Mixed Cereal Grains Ameliorate the Azoxymethane and Dextran Sodium Sulfate-Induced Colonic Carcinogenesis in C57BL/6J Mice
Jia-Le Song, Jung-Sook Lee, Hee-Young Kim, Byung-Jin Jeong, Jong-Sung Jeong, Tae-Gon Huh, Kun-Young Park
Journal of Medicinal Food.2020; 23(4): 440. CrossRef - Unmet Clinical Needs in the Treatment of Patients with Thyroid Cancer
Won Bae Kim, Min Ji Jeon, Won Gu Kim, Tae Yong Kim, Young Kee Shong
Endocrinology and Metabolism.2020; 35(1): 14. CrossRef - Regional nodal irradiation in pT1-2N1 breast cancer patients treated with breast-conserving surgery and whole breast irradiation
Shin-Hyung Park, Jae-Chul Kim
Radiation Oncology Journal.2020; 38(1): 44. CrossRef - Targeted Therapy for Non-Small Cell Lung Cancer
Jung Sun Kim, Eun Joo Kang
The Korean Journal of Medicine.2020; 95(2): 78. CrossRef - Prediction of Cancer Incidence and Mortality in Korea, 2020
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Cancer Research and Treatment.2020; 52(2): 351. CrossRef - Body Mass Index and Risk of Gastric Cancer in Asian Adults: A Meta-Epidemiological Meta-Analysis of Population-Based Cohort Studies
Jong-Myon Bae
Cancer Research and Treatment.2020; 52(2): 369. CrossRef - Impact of Angiotensin Receptor Blockers, Beta Blockers, Calcium Channel Blockers and Thiazide Diuretics on Survival of Ovarian Cancer Patients
Min Ae Cho, Soo Young Jeong, Insuk Sohn, Myeong-Seon Kim, Jun Hyeok Kang, E Sun Paik, Yoo-Young Lee, Chel Hun Choi
Cancer Research and Treatment.2020; 52(2): 645. CrossRef - Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2017
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- Prediction of Cancer Incidence and Mortality in Korea, 2019
- Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Eun Sook Lee
- Cancer Res Treat. 2019;51(2):431-437. Published online March 18, 2019
- DOI: https://doi.org/10.4143/crt.2019.139
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Abstract
PDFPubReaderePub
- Purpose
This study aimed to report on cancer incidence and mortality for the year 2019 to estimate Korea’s current cancer burden.
Materials and Methods
Cancer incidence data from 1999 to 2016 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2017 were acquired from Statistics Korea. Cancer incidence and mortality were projected by fitting a linear regression model to observed age-specific cancer rates against observed years, then multiplying the projected age-specific rates by the age-specific population. The Joinpoint regression model was used to determine at which year the linear trend changed significantly; we used only the data of the latest trend.
Results
A total of 221,347 new cancer cases and 82,344 cancer deaths are expected to occur in Korea in 2019. The most common cancer sites thus far have been the lung, followed by the stomach, colon and rectum, breast, and liver. These five cancers represent half of the overall burden of cancer in Korea. For cancer associated mortality, the most common sites were lung, followed by the liver, colon and rectum, stomach, and pancreas.
Conclusion
The incidence rate of all cancer in Korea is estimated to decrease gradually. These up-todate estimates of the cancer burden in Korea could be an important resource for planning and evaluating cancer-control programs. -
Citations
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Diagnostics.2022; 12(9): 2203. CrossRef - Colonic Chicken Skin Mucosa Surrounding Colon Polyps Is an Endoscopic Predictive Marker for Colonic Neoplastic Polyps
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Endocrine Journal.2020; 67(6): 577. CrossRef - Breast Cancer Risk Prediction in Korean Women: Review and Perspectives on Personalized Breast Cancer Screening
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Korean Journal of Women Health Nursing.2019; 25(4): 434. CrossRef - Female hormones and the risk of colorectal neoplasm
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Nutrients.2019; 11(8): 1949. CrossRef - Does Holding Back Cancer-Related Concern Affect Couples' Marital Relationship and Quality of Life of Patients with Lung Cancer? An Actor–Partner Interdependence Mediation Modeling Approach
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Ji Yun Baek, Tuy An Trinh, Wonsang Huh, Ji Hoon Song, Hyun Young Kim, Juhee Lim, Jinhee Kim, Hyun Jin Choi, Tae-Hun Kim, Ki Sung Kang
Biomolecules.2019; 9(10): 624. CrossRef - Conversion Surgery in Metastatic Gastric Cancer and Cancer Dormancy as a Prognostic Biomarker
Hun Jee Choe, Jin Won Kim, Song-Hee Han, Ju Hyun Lee, Sang-Hoon Ahn, Do Joong Park, Ji-Won Kim, Yu Jung Kim, Hye Seung Lee, Jee Hyun Kim, Hyung-Ho Kim, Keun-Wook Lee
Cancers.2019; 12(1): 86. CrossRef
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Original Articles
- Preclinical Efficacy of [V4 Q5 ]dDAVP, a Second Generation Vasopressin Analog, on Metastatic Spread and Tumor-Associated Angiogenesis in Colorectal Cancer
- Juan Garona, Natasha T. Sobol, Marina Pifano, Valeria I. Segatori, Daniel E. Gomez, Giselle V. Ripoll, Daniel F. Alonso
- Cancer Res Treat. 2019;51(2):438-450. Published online June 1, 2018
- DOI: https://doi.org/10.4143/crt.2018.040
-
Abstract
PDF
Supplementary MaterialPubReaderePub - Purpose
Control of metastatic spread of colorectal cancer (CRC) remains as a major therapeutic challenge. [V4 Q5 ]dDAVP is a vasopressin peptide analog with previously reported anticancer activity against carcinoma tumors. By acting as a selective agonist of arginine vasopressin type 2 membrane receptor (AVPR2) present in endothelial and tumor cells, [V4Q5]dDAVP is able to impair tumor aggressiveness and distant spread. Our aim was to evaluate the potential therapeutic benefits of [V4Q5]dDAVP on highly aggressive CRC disease using experimental models with translational relevance.
Materials and Methods
Murine CT-26 and human Colo-205 AVPR2-expressing CRC cell lines were used to test the preclinical efficacy of [V4Q5]dDAVP, both in vitro and in vivo.
Results
In syngeneic mice surgically implanted with CT-26 cells in the spleen, sustained intravenous treatment with [V4Q5]dDAVP (0.3 µg/kg) dramatically impaired metastatic progression to liver without overt signs of toxicity, and also reduced experimental lung colonization. The compound inhibited in vivo angiogenesis driven by Colo-205 cells in athymic mice, as well as in vitro endothelial cell migration and capillary tube formation. [V4Q5]dDAVP exerted AVPR2-dependent cytostatic activity in vitro (IC50 1.08 µM) and addition to 5-fluorouracil resulted in synergistic antiproliferative effects both in CT-26 and Colo-205 cells.
Conclusion
The present preclinical study establishes for the first time the efficacy of [V4Q5]dDAVP on CRC. These encouraging results suggest that the novel second generation vasopressin analog could be used for the management of aggressive CRC as an adjuvant agent during surgery or to complement standard chemotherapy, limiting tumor angiogenesis and metastasis and thus protecting the patient from CRC recurrence. -
Citations
Citations to this article as recorded by- Gastrointestinal digestion of food proteins: Anticancer, antihypertensive, anti-obesity, and immunomodulatory mechanisms of the derived peptides
Zheng Yan, Yang Gui, Chunhong Liu, Xiaohai Zhang, Chaoling Wen, Opeyemi Joshua Olatunji, Itthanan Suttikhana, Tolulope Joshua Ashaolu
Food Research International.2024; 189: 114573. CrossRef - AVPR2 is a potential prognostic biomarker and correlated with immune infiltration in head and neck squamous cell carcinoma
Linwei Mao, Zhiyong Pan, Wenzhi Chen, Weiqun Hu, Xiufen Chen, Huiting Dai
BMC Medical Genomics.2023;[Epub] CrossRef - Circulating Levels of the Cardiovascular Biomarkers ST2 and Adrenomedullin Predict Outcome within a Randomized Phase III Lung Cancer Trial (RASTEN)
Emelie Gezelius, Pär-Ola Bendahl, Widet Gallo, Kelin Gonçalves de Oliveira, Lars Ek, Bengt Bergman, Jan Sundberg, Olle Melander, Mattias Belting
Cancers.2022; 14(5): 1307. CrossRef - Vasopressin and Its Analogues: From Natural Hormones to Multitasking Peptides
Mladena Glavaš, Agata Gitlin-Domagalska, Dawid Dębowski, Natalia Ptaszyńska, Anna Łęgowska, Krzysztof Rolka
International Journal of Molecular Sciences.2022; 23(6): 3068. CrossRef - Identification of Hub Genes of Lung Adenocarcinoma Based on Weighted Gene Co-Expression Network in Chinese Population
Yuning Xie, Hongjiao Wu, Wenqian Hu, Hongmei Zhang, Ang Li, Zhi Zhang, Shuhua Ren, Xuemei Zhang
Pathology and Oncology Research.2022;[Epub] CrossRef - Propranolol blocks osteosarcoma cell cycle progression, inhibits angiogenesis and slows xenograft growth in combination with cisplatin-based chemotherapy
Luisina M. Solernó, Natasha T. Sobol, María F. Gottardo, Carla S. Capobianco, Maximiliano R. Ferrero, Liliana Vásquez, Daniel F. Alonso, Juan Garona
Scientific Reports.2022;[Epub] CrossRef - Genetic Determination of Regressive Pattern of Walker 256 Carcinosarcoma in Rats with Hypothalamic Diabetes Insipidus
I. I. Khegay
Bulletin of Experimental Biology and Medicine.2022; 173(4): 441. CrossRef - Vasopressin Receptors in Blood Vessels and Proliferation of Endotheliocytes
I. I. Khegay
Russian Journal of Bioorganic Chemistry.2021; 47(4): 815. CrossRef - Targeting the vasopressin type-2 receptor for renal cell carcinoma therapy
Sonali Sinha, Nidhi Dwivedi, Shixin Tao, Abeda Jamadar, Vijayakumar R. Kakade, Maura O’ Neil, Robert H. Weiss, Jonathan Enders, James P. Calvet, Sufi M. Thomas, Reena Rao
Oncogene.2020; 39(6): 1231. CrossRef - Administration of the vasopressin analog desmopressin for the management of bleeding in rectal cancer patients: results of a phase I/II trial
Soledad Iseas, Enrique L. Roca, Juan M. O’Connor, Martin Eleta, Analia Sanchez-Luceros, Daniela Di Leo, Marcelo Tinelli, Maria L. Fara, Eduardo Spitzer, Ignacio A. Demarco, Giselle V. Ripoll, Marina Pifano, Juan Garona, Daniel F. Alonso
Investigational New Drugs.2020; 38(5): 1580. CrossRef - The Anticancer Properties of Tanshinones and the Pharmacological Effects of Their Active Ingredients
Li Fu, Bing Han, Yang Zhou, Jie Ren, Wenzhi Cao, Gopal Patel, Guoyin Kai, Jun Zhang
Frontiers in Pharmacology.2020;[Epub] CrossRef - Potential Use of Desmopressin During Hepatic Resection for Colorectal Liver Metastases*
Juan Garona, Natasha T. Sobol, Luisina M. Solernó, Daniel F. Alonso
Journal of Surgical Research.2019; 237: 1. CrossRef
- Gastrointestinal digestion of food proteins: Anticancer, antihypertensive, anti-obesity, and immunomodulatory mechanisms of the derived peptides
- 9,828 View
- 280 Download
- 18 Web of Science
- 12 Crossref
- Pan-Pim Kinase Inhibitor AZD1208 Suppresses Tumor Growth and Synergistically Interacts with Akt Inhibition in Gastric Cancer Cells
- Miso Lee, Kyung-Hun Lee, Ahrum Min, Jeongeun Kim, Seongyeong Kim, Hyemin Jang, Jee Min Lim, So Hyeon Kim, Dong-Hyeon Ha, Won Jae Jeong, Koung Jin Suh, Yae-Won Yang, Tae Yong Kim, Do-Youn Oh, Yung-Jue Bang, Seock-Ah Im
- Cancer Res Treat. 2019;51(2):451-463. Published online June 6, 2018
- DOI: https://doi.org/10.4143/crt.2017.341
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Pim kinases are highly conserved serine/threonine kinases, and different expression patterns of each isoform (Pim-1, Pim-2, and Pim-3) have been observed in various types of human cancers, including gastric cancer. AZD1208 is a potent and selective inhibitor that affects all three isoforms of Pim. We investigated the effects of AZD1208 as a single agent and in combination with an Akt inhibitor in gastric cancer cells.
Materials and Methods
The antitumor activity of AZD1208 with/without an Akt inhibitor was evaluated in a large panel of gastric cancer cell lines through growth inhibition assays. The underlying mechanism was also examined by western blotting, immunofluorescence assay, and cell cycle analysis.
Results
AZD1208 treatment decreased gastric cancer cell proliferation rates and induced autophagy only in long-term culture systems. Light chain 3B (LC3B), a marker of autophagy, was increased in sensitive cells in a dose-dependent manner with AZD1208 treatment, which suggested that the growth inhibition effect of AZD1208 was achieved through autophagy, not apoptosis. Moreover, we found that cells damaged by Pim inhibition were repaired by activation of the DNA damage repair pathway, which promoted cell survival and led the cells to become resistant to AZD1208. We also confirmed that the combination of an Akt inhibitor with AZD1208 produced a highly synergistic effect in gastric cancer cell lines.
Conclusion
Treatment with AZD1208 alone induced considerable cell death through autophagy in gastric cancer cells. Moreover, the combination of AZD1208 with an Akt inhibitor showed synergistic antitumor effects through regulation of the DNA damage repair pathway. -
Citations
Citations to this article as recorded by- PIM1 attenuates cisplatin-induced AKI by inhibiting Drp1 activation
Yuzhen Li, Lang Shi, Fan Zhao, Yanwen Luo, Mingjiao Zhang, Xiongfei Wu, Jiefu Zhu
Cellular Signalling.2024; 113: 110969. CrossRef - Prognostic Model Construction of Disulfidptosis-Related Genes and Targeted Anticancer Drug Research in Pancreatic Cancer
Hongtao Duan, Li Gao, Aiminuer Asikaer, Lingzhi Liu, Kuilong Huang, Yan Shen
Molecular Biotechnology.2024;[Epub] CrossRef - PIM1 kinase and its diverse substrate in solid tumors
Rituparna Choudhury, Chandan Kumar Bahadi, Ipsa Pratibimbita Ray, Pragyanshree Dash, Isha Pattanaik, Suman Mishra, Soumya R. Mohapatra, Srinivas Patnaik, Kumar Nikhil
Cell Communication and Signaling.2024;[Epub] CrossRef - The evaluation of six genes combined value in glioma diagnosis and prognosis
Ping Lin, Lingyan He, Nan Tian, Xuchen Qi
Journal of Cancer Research and Clinical Oncology.2023; 149(13): 12413. CrossRef - Toxic effects of AZD1208 on mouse oocytes and its possible mechanisms
Feng‐Ze Yan, Ying‐Chun Ouyang, Tie‐Gang Meng, Hong‐Yong Zhang, Wei Yue, Xin‐Ran Zhang, Yue Xue, Zhen‐Bo Wang, Qing‐Yuan Sun
Journal of Cellular Physiology.2022; 237(9): 3661. CrossRef - Therapeutic targeting of PIM KINASE signaling in cancer therapy: Structural and clinical prospects
Aanchal Rathi, Dhiraj Kumar, Gulam Mustafa Hasan, Mohammad Mahfuzul Haque, Md Imtaiyaz Hassan
Biochimica et Biophysica Acta (BBA) - General Subjects.2021; 1865(11): 129995. CrossRef - TDP1 and TOP1 Modulation in Olaparib-Resistant Cancer Determines the Efficacy of Subsequent Chemotherapy
Jin Won Kim, Ahrum Min, Seock-Ah Im, Hyemin Jang, Yu Jin Kim, Hee-Jun Kim, Kyung-Hun Lee, Tae-Yong Kim, Keun Wook Lee, Do-Youn Oh, Jee-Hyun Kim, Yung-Jue Bang
Cancers.2020; 12(2): 334. CrossRef - PIM1 (Moloney Murine Leukemia Provirus Integration Site) Inhibition Decreases the Nonhomologous End-Joining DNA Damage Repair Signaling Pathway in Pulmonary Hypertension
Marie-Claude Lampron, Géraldine Vitry, Valérie Nadeau, Yann Grobs, Renée Paradis, Nolwenn Samson, Ève Tremblay, Olivier Boucherat, Jolyane Meloche, Sébastien Bonnet, Steeve Provencher, François Potus, Roxane Paulin
Arteriosclerosis, Thrombosis, and Vascular Biology.2020; 40(3): 783. CrossRef - Inhibition of PIM1 attenuates the stem cell–like traits of breast cancer cells by promoting RUNX3 nuclear retention
Hui Liu, Cheng Chen, Dongshen Ma, Yubing Li, Qianqian Yin, Qing Li, Chenxi Xiang
Journal of Cellular and Molecular Medicine.2020; 24(11): 6308. CrossRef - Antitumor effect of a WEE1 inhibitor and potentiation of olaparib sensitivity by DNA damage response modulation in triple-negative breast cancer
Dong-Hyeon Ha, Ahrum Min, Seongyeong Kim, Hyemin Jang, So Hyeon Kim, Hee-Jun Kim, Han Suk Ryu, Ja-Lok Ku, Kyung-Hun Lee, Seock-Ah Im
Scientific Reports.2020;[Epub] CrossRef - Pim kinase inhibitors in cancer: medicinal chemistry insights into their activity and selectivity
Soraya Alnabulsi, Enas A. Al-Hurani
Drug Discovery Today.2020; 25(11): 2062. CrossRef - New Mechanistic Insight on the PIM-1 Kinase Inhibitor AZD1208 Using Multidrug Resistant Human Erythroleukemia Cell Lines and Molecular Docking Simulations
Maiara Bernardes Marques, Michael González-Durruthy, Bruna Félix da Silva Nornberg, Bruno Rodrigues Oliveira, Daniela Volcan Almeida, Ana Paula de Souza Votto, Luis Fernando Marins
Current Topics in Medicinal Chemistry.2019; 19(11): 914. CrossRef - Recent Studies on Ponatinib in Cancers Other Than Chronic Myeloid Leukemia
Francesca Musumeci, Chiara Greco, Giancarlo Grossi, Alessio Molinari, Silvia Schenone
Cancers.2018; 10(11): 430. CrossRef
- PIM1 attenuates cisplatin-induced AKI by inhibiting Drp1 activation
- 11,841 View
- 362 Download
- 15 Web of Science
- 13 Crossref
- Combination Treatment of Stereotactic Body Radiation Therapy and Immature Dendritic Cell Vaccination for Augmentation of Local and Systemic Effects
- Chul Won Choi, Min Ho Jeong, You-Soo Park, Cheol-Hun Son, Hong-Rae Lee, Eun-Kyoung Koh
- Cancer Res Treat. 2019;51(2):464-473. Published online June 6, 2018
- DOI: https://doi.org/10.4143/crt.2018.186
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
The purpose of this study was to investigate the efficacy of stereotactic body radiation therapy (SBRT) as a tumor-associated antigen (TAA) presentation method for dendritic cell (DC) sensitization and evaluate its effect in combination with immunotherapy using an intratumoral injection of immature DCs (iDCs).
Methods
and Materials CT-26 colon carcinoma cell was used as a cancer cell line. Annexin V staining and phagocytosis assays were performed to determine the appropriate radiation dose and incubation time to generate TAAs. BALB/c mice were used for in vivo experiments. Cancer cells were injected into the right legs and left flanks to generate primary and metastatic tumors, respectively. The mice were subjected to radiation therapy (RT) alone, intradermal injection of electroporated DCs alone, or RT in combination with iDC intratumoral injection (RT/iDC). Tumor growth measurement and survival rate analysis were performed. Enzyme-linked immunospot and cytotoxicity assays were performed to observe the effect of different treatments on the immune system.
Results
Annexin V staining and phagocytosis assays showed that 15 Gy radiation dose and 48 hours of incubation was appropriate for subsequent experiments. Maximum DC sensitization and T-cell stimulation was observed with RT as compared to other TAA preparation methods. In vivo assays revealed statistically significant delay in the growth of both primary and metastatic tumors in the RT/iDC group. The overall survival rate was the highest in the RT/iDC group.
Conclusion
The combination of SBRT and iDC vaccination may enhance treatment effects. Clinical trials and further studies are warranted in the future. -
Citations
Citations to this article as recorded by- Neoadjuvant SBRT combined with immunotherapy in NSCLC: from mechanisms to therapy
Yanhong Shi, Xiaoyan Ma, Dan He, Bingwei Dong, Tianyun Qiao
Frontiers in Immunology.2023;[Epub] CrossRef - Therapeutic strategies for gastric cancer targeting immune cells: Future directions
Yan Zhao, Yuansong Bai, Meili Shen, Yapeng Li
Frontiers in Immunology.2022;[Epub] CrossRef - Recent Advances and Future Perspective of DC-Based Therapy in NSCLC
Iris A. E. van der Hoorn, Georgina Flórez-Grau, Michel M. van den Heuvel, I. Jolanda M. de Vries, Berber Piet
Frontiers in Immunology.2021;[Epub] CrossRef - Successful Treatment of Advanced Gastric Cancer with Brain Metastases through an Abscopal Effect by Radiation and Immune Checkpoint Inhibitor Therapy
Momotaro Muto, Hirotaka Nakata, Kenichi Ishigaki, Shion Tachibana, Moe Yoshida, Mizue Muto, Nobuyuki Yanagawa, Toshikatsu Okumura
Journal of Gastric Cancer.2021; 21(3): 319. CrossRef - Intelligent photothermal dendritic cells restart the cancer immunity cycle through enhanced immunogenic cell death
Zhihong Sun, Guanjun Deng, Xinghua Peng, Xiuli Xu, Lanlan Liu, Jiaofeng Peng, Yifan Ma, Pengfei Zhang, Austin Wen, Yifan Wang, Zhaogang Yang, Ping Gong, Wen Jiang, Lintao Cai
Biomaterials.2021; 279: 121228. CrossRef - Prediction and identification of novel HLA-A*0201-restricted cytotoxic T lymphocyte epitopes from endocan
Gaohai Shao, Qingjun Liu, Ling Yang, Guibo Feng, Wang Zhao, Zhongyan Huang, Zhao Yang
Journal of Inflammation.2020;[Epub] CrossRef HMGB1 in Radiotherapy: A Two Headed Signal Regulating Tumor Radiosensitivity and Immunity
Yin Liao, Shuya Liu, Shaozhi Fu, Jingbo Wu
OncoTargets and Therapy.2020; Volume 13: 6859. CrossRef- Immunotherapy as sensitizer for local radiotherapy
Ben G.L. Vanneste, Evert J Van Limbergen, Ludwig Dubois, Iryna V. Samarska, L. Wieten, M. J.B. Aarts, T. Marcelissen, Dirk De Ruysscher
OncoImmunology.2020;[Epub] CrossRef - Effective Combinations of Radiotherapy and Immunotherapy in the Treatment of Esophageal Squamous Cell Carcinoma
Yang Yang, Hong Ge
Future Oncology.2020; 16(31): 2537. CrossRef - Abscopal effect of stereotactic radiotherapy combined with anti‐PD‐1/PD‐L1 immunotherapy: Mechanisms, clinical efficacy, and issues
Hongqing Zhuang
Cancer Communications.2020; 40(12): 649. CrossRef - A Characterization of Dendritic Cells and Their Role in Immunotherapy in Glioblastoma: From Preclinical Studies to Clinical Trials
Siddhartha Srivastava, Christina Jackson, Timothy Kim, John Choi, Michael Lim
Cancers.2019; 11(4): 537. CrossRef - Current status of immune checkpoint inhibition in early-stage NSCLC
J. Vansteenkiste, E. Wauters, B. Reymen, C.J. Ackermann, S. Peters, D. De Ruysscher
Annals of Oncology.2019; 30(8): 1244. CrossRef - Local Irradiation Sensitized Tumors to Adoptive T Cell Therapy via Enhancing the Cross-Priming, Homing, and Cytotoxicity of Antigen-Specific CD8 T Cells
Jin-Zhi Lai, Yan-Yang Zhu, Mei Ruan, Ling Chen, Qiu-Yu Zhang
Frontiers in Immunology.2019;[Epub] CrossRef - Nutraceutical Compounds as Sensitizers for Cancer Treatment in Radiation Therapy
Marco Calvaruso, Gaia Pucci, Rosa Musso, Valentina Bravatà, Francesco P. Cammarata, Giorgio Russo, Giusi I. Forte, Luigi Minafra
International Journal of Molecular Sciences.2019; 20(21): 5267. CrossRef
- Neoadjuvant SBRT combined with immunotherapy in NSCLC: from mechanisms to therapy
- 8,793 View
- 262 Download
- 16 Web of Science
- 14 Crossref
- Long-term Outcomes of One Stage Surgery Using Transanal Colorectal Tube for Acute Colorectal Obstruction of Stage II/III Distal Colon Cancer
- Yusuke Okuda, Tomonori Yamada, Yoshikazu Hirata, Takaya Shimura, Ryuzo Yamaguchi, Eiji Sakamoto, Satoshi Sobue, Takahiro Nakazawa, Hiromi Kataoka, Takashi Joh
- Cancer Res Treat. 2019;51(2):474-482. Published online June 6, 2018
- DOI: https://doi.org/10.4143/crt.2018.059
-
Abstract
PDFPubReaderePub
- Purpose
Since oncological outcomes of transanal colorectal tube (TCT) placement, an endoscopic treatment for colorectal cancer (CRC) with acute colorectal obstruction (ACO), remain unknown, this study analyzed long-term outcomes of TCT placement for stage II/III CRC with ACO.
Materials and Methods
Data were retrospectively reviewed from consecutive patients with distal stage II/III CRC who underwent surgery between January 2007 and December 2011 at two Japanese hospitals. One hospital conducted emergency surgery and the other performed TCT placement as the standard treatment for all CRCs with ACO. Propensity score (PS) matching was used to adjust baseline characteristics between two groups.
Results
Among 754 patients with distal stage II/III CRC, 680 did not have ACO (non-ACO group) and 74 had ACO (ACO group). The PS matching between both hospitals identified 234 pairs in the non-ACO group and 23 pairs in the ACO group. In the non-ACO group, the surgical quality was equivalent between the two institutions, with no significant differences in overall survival (OS) and disease-free survival (DFS). In the ACO group, the rate of primary resection/anastomosis was higher in the TCT group than in the surgery group (87.0% vs. 26.1%, p < 0.001). No significant differences were noted between the surgery and the TCT groups in OS (5-year OS, 61.9% vs. 51.5%; p=0.490) and DFS (5-year DFS, 45.9% vs. 38.3%; p=0.658).
Conclusion
TCT placement can achieve similar long-term outcomes to emergency surgery, with a high rate of primary resection/anastomosis for distal stage II/III colon cancer with ACO. -
Citations
Citations to this article as recorded by- Which treatment strategy is optimal for acute left-sided malignant colonic obstruction? A Bayesian meta-analysis
Kaibo Ouyang, Zifeng Yang, Yuesheng Yang, Junjiang Wang, Deqing Wu, Yong Li
International Journal of Colorectal Disease.2023;[Epub] CrossRef - A multicenter case–control study of self-expanding metallic stent versus trans-anal colorectal tube for stage II/III non-right-sided obstructive colon cancer
Yusuke Okuda, Takaya Shimura, Konomu Uno, Tomonori Yamada, Takayuki Nukui, Takashi Mizushima, Yuya Takenaka, Keisuke Itoh, Yuki Inagaki, Takanori Ozeki, Kazuhiro Nagao, Masahide Ebi, Erika Uchida, Satoshi Nomura, Yu Nojiri, Shozo Togawa, Naomi Sugimura, S
Journal of Gastroenterology.2023; 58(3): 217. CrossRef - Long-term and short-term outcomes of laparoscopic versus open resection following tube decompression for obstructive colorectal cancer: a single-center retrospective study
Kiyoaki Sugiura, Yuki Seo, Hikaru Aoki, Yoshihiko Onishi, Yusuke Nishi, Norihiro Kishida, Motomu Tanaka, Yasuhiro Ito, Hideyuki Tokura, Takayuki Takahashi
Surgery Today.2022; 52(9): 1284. CrossRef - Comparison of the prognosis of four different treatment strategies for acute left malignant colonic obstruction: a systematic review and network meta-analysis
Ling Tan, Zi-lin Liu, Meng-ni Ran, Ling-han Tang, Yan-jun Pu, Yi-lei Liu, Zhou Ma, Zhou He, Jiang-wei Xiao
World Journal of Emergency Surgery.2021;[Epub] CrossRef - A nomogram model for predicting prognosis of obstructive colorectal cancer
Jian Lv, Yuan yuan Liu, Yi tao Jia, Jing li He, Guang yao Dai, Peng Guo, Zhao long Zhao, Yan ni Zhang, Zhong xin Li
World Journal of Surgical Oncology.2021;[Epub] CrossRef - The long non‐coding RNA HCG18 promotes the growth and invasion of colorectal cancer cells through sponging miR‐1271 and upregulating MTDH/Wnt/β‐catenin
Shunle Li, Tao Wu, Di Zhang, Xiaoli Sun, Xinwu Zhang
Clinical and Experimental Pharmacology and Physiology.2020; 47(4): 703. CrossRef - MicroRNA‐876‐5p represses the cell proliferation and invasion of colorectal cancer through suppressing YAP signalling via targeting RASAL2
Li Ren, Zhiyong Zhang, Yun Feng, Miaosha Luo, Zhiming Hao
Clinical and Experimental Pharmacology and Physiology.2020; 47(5): 867. CrossRef - Pathological impact of transanal colorectal tube for obstructive colorectal cancer
Yusuke Okuda, Takaya Shimura, Hiroyuki Kato, Tomonori Yamada, Yoshikazu Hirata, Makoto Natsume, Hiroyasu Iwasaki, Ryuzo Yamaguchi, Eiji Sakamoto, Satoru Takahashi, Hiromi Kataoka
Surgical Endoscopy.2020; 34(9): 4011. CrossRef
- Which treatment strategy is optimal for acute left-sided malignant colonic obstruction? A Bayesian meta-analysis
- 7,434 View
- 235 Download
- 9 Web of Science
- 8 Crossref
- The Lymphatic Drainage Pattern of Internal Mammary Sentinel Lymph Node Identified by Small Particle Radiotracer (99mTc-Dextran 40) in Breast
- Xiao-Shan Cao, Guo-Ren Yang, Bin-Bin Cong, Peng-Fei Qiu, Yong-Sheng Wang
- Cancer Res Treat. 2019;51(2):483-492. Published online June 11, 2018
- DOI: https://doi.org/10.4143/crt.2018.062
-
Abstract
PDFPubReaderePub
- Purpose
The purpose of this study was to detect the lymphatic drainage pattern of internal mammary area and verify the concept of internal mammary sentinel lymph node (IM-SLN) in breast.
Materials and Methods
A small particle radiotracer (99mTc-Dextran 40) was prepared and tested. 99mTc-Dextran 40 was injected into intraparenchyma at the sound breast by a modified radiotracer injection technique. Subsequently, dynamic single-photon emission computed tomography (SPECT), computed tomography (CT), and SPECT/CT combination images were performed to identify the radioactive lymph vessels and internal mammary lymph nodes (IMLNs). The direction of lymph drainage and the location of the IMLNs were identified in the SPECT/CT imaging.
Results
The radiochemical purity of 99mTc-Dextran 40 was > 95%. 99mTc-Dextran 40 could drainage into first, second, and third lymph node and the radioactive lymph node could be detected by the γ detector in the animal experiment. After 99mTc-Dextran 40 injecting into intraparenchyma, 50.0% cases (15/30) were identified the drainage lymphatic vessels and radioactive IMLNs by SPECT. The drainage lymphatic vessel was found from injection point to the first IMLN (IM-SLN) after 10.5±0.35 minutes radiotracer injection, and then 99mTc-Dextran 40 was accumulated into the IM-SLN. The combination imaging of SPECT/CT showed the second IMLN received the lymph drainage from the IM-SLN. The lymphatic drainage was step by step in the internal mammary area.
Conclusion
The lymph was identified to drain from different regions of the breast to IM-SLN, and then outward from IM-SLN to other IMLN consecutively. It demonstrated the concept of the IM-SLN and provided more evidences for the application of internal mammary sentinel lymph node biopsy. -
Citations
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Wenxin Chen, Yaodong Su, Hui Zhang, Yu Zhang, Lin Zhu, Mengbo Lin, Zhiyi Lin, Mingdian Yu, Shengping Yang, Yanmin Zhang
Frontiers in Oncology.2023;[Epub] CrossRef - Internal mammary lymph node metastasis in breast cancer patients based on anatomical imaging and functional imaging
Wei Wang, Pengfei Qiu, Jianbin Li
Breast Cancer.2022; 29(6): 933. CrossRef - The hypothesis of internal mammary lymph node drainage chain in breast cancer
Zhao Bi, Peng Chen, Xian-Rang Song, Yong-Sheng Wang
Future Oncology.2020; 16(21): 1489. CrossRef - Comparative research on 99mTc-Rituximab and 99mTc-sulfur colloid in sentinel lymph node imaging of breast cancer
Jing-Jie Zhang, Wan-Chun Zhang, Cai-Xia An, Xiao-Min Li, Le Ma
BMC Cancer.2019;[Epub] CrossRef
- 99mTc-rituximab tracer injection for guiding internal mammary sentinel lymph nodes biopsy in primary breast cancer: A prospective observational study
- 10,640 View
- 169 Download
- 5 Web of Science
- 4 Crossref
- EGFR Mutation Is Associated with Short Progression-Free Survival in Patients with Stage III Non-squamous Cell Lung Cancer Treated with Concurrent Chemoradiotherapy
- Song Ee Park, Jae Myoung Noh, You Jin Kim, Han Sang Lee, Jang Ho Cho, Sung Won Lim, Yong Chan Ahn, Hongryull Pyo, Yoon-La Choi, Joungho Han, Jong-Mu Sun, Se Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn
- Cancer Res Treat. 2019;51(2):493-501. Published online June 18, 2018
- DOI: https://doi.org/10.4143/crt.2018.125
-
Abstract
PDFPubReaderePub
- Purpose
This study was conducted to evaluate the relationship between epidermal growth factor receptor (EGFR) mutation and clinical outcomes in patients with stage III non-squamous cell lung cancer treated with definitive concurrent chemoradiotherapy (CCRT).
Materials and Methods
From January 2008 to December 2013, the medical records of 197 patients with stage III non- squamous non-small cell lung cancer treated with definitive CCRT were analyzed to determine progression-free survival (PFS) and overall survival (OS) according to EGFR mutation status.
Results
Among 197 eligible patients, 81 patients were EGFR wild type, 36 patients had an EGFR mutation (exon 19 Del, n=18; L858R, n=9, uncommon [G719X, L868, T790M], n=9), and 80 patients had unknown EGFR status. The median age was 59 years (range, 28 to 80 years) and 136 patients (69.0%) were male. The median follow-up duration was 66.5 months (range, 1.9 to 114.5 months). One hundred sixty-four patients (83.2%) experienced disease progression. Median PFS was 8.9 months for the EGFR mutation group, 11.8 months for EGFR wild type, and 10.5 months for the unknown EGFR group (p=0.013 and p=0.042, respectively). The most common site of metastasis in the EGFR mutant group was the brain. However, there was no significant difference in OS among the three groups (34.6 months for EGFR mutant group vs. 31.9 months for EGFR wild type vs. 22.6 months for EGFR unknown group; p=0.792 and p=0.284). A total of 29 patients (80.6%) with EGFR mutation were treated with EGFR tyrosine kinase inhibitor (gefitinib, n=24; erlotinib, n=3; afatinib, n=2) upon progression.
Conclusion
EGFR mutation is associatedwith short PFS and the brain is the most common site of distant metastasis in patients with stage III non- squamous cell lung cancer treated with CCRT. -
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- Efficacy and Safety of Afatinib for EGFR-mutant Non-small Cell Lung Cancer, Compared with Gefitinib or Erlotinib
- Youjin Kim, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park, Jong-Mu Sun
- Cancer Res Treat. 2019;51(2):502-509. Published online June 13, 2018
- DOI: https://doi.org/10.4143/crt.2018.117
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
We tried to evaluate whether there are any specific features in treatment outcomes of firstline afatinib in patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC), compared with gefitinib or erlotinib.
Materials and Methods
We analyzed patients treated with first-line afatinib, gefitinib, or erlotinib for advanced EGFR-mutant NSCLC at Samsung Medical Center between 2014 and 2016.
Results
In total, 467 patients received first-line afatinib (n=165), gefitinib (n=230), or erlotinib (n=72). Afatinib was used more often in patients with tumors harboring deletion in exon 19 (Del19), whereas the gefitinib group had more elderly, females, and never smokers. The median progression-free survival (PFS) time for afatinib, gefitinib, and erlotinib was 19.1 months, 13.7 months, and 14.0 months, respectively (p=0.001). The superior PFS of afatinib was more remarkable in subgroups of Del19 or uncommon EGFR mutations. Overall toxicity profiles of the three drugs were comparable, though more grade 3 or 4 toxicities were detected in afatinib (7.3%) compared with gefitinib (2.6%) or erlotinib (1.8%). The common grade 3 or 4 toxicities of afatinib included diarrhea (3.0%), paronychia (2.4%), and skin rash (1.8%). Dose modification was more frequently required in patients treated with afatinib (112/165, 68%), compared with gefitinib (5/230, 2%) and erlotinib (4/72, 6%). Interestingly, however, dose reduction in the afatinib group did not impair its efficacy in terms of PFS (dose reduction vs. no reduction group, 23.5 months vs. 12.4 months).
Conclusion
First-line afatinib showed satisfactory efficacy data and manageable toxicity profiles. -
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Sequential treatment with afatinib and osimertinib in patients with
EGFR
mutation-positive non-small-cell lung cancer: an observational study
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- 64 Crossref
- Phase I Dose-Finding Study of OPB-111077, a Novel STAT3 Inhibitor, in Patients with Advanced Hepatocellular Carcinoma
- Changhoon Yoo, Jihoon Kang, Ho Yeong Lim, Jee Hyun Kim, Myung-Ah Lee, Kyung-Hun Lee, Tae-You Kim, Baek-Yeol Ryoo
- Cancer Res Treat. 2019;51(2):510-518. Published online June 13, 2018
- DOI: https://doi.org/10.4143/crt.2018.226
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
The signal transducer and activator of transcription 3 (STAT3) signaling pathway might be a promising therapeutic target for hepatocellular carcinoma (HCC).
Materials and Methods
This study was a multicenter, open-label, non-comparative, dose escalating phase I study of OPB-111077, an oral STAT3 inhibitor, in patients with advanced HCC who failed on sorafenib. Continuous dosing (daily administration, 50 to 400 mg) and intermittent dosing (4-days on/3-days off administration: 300 to 900 mg) regimens were evaluated and the dose-limiting toxicities (DLTs), maximum tolerated dose (MTD), and recommended dose (RD) were the primary endpoints.
Results
A total of 33 patients (19 for continuous dosing and 14 for intermittent dosing) were enrolled. One patient experienced a DLT with grade 3 dizziness, but the MTD was identified in neither the continuous nor the intermittent dosing cohorts. The RDs were determined to be 250 mg for the continuous dosing regimen and 600 mg for the intermittent dosing regimen. There was no treatment-related death; five patients (15.2%) had grade 3-4 toxicities including thrombocytopenia (6%), fatigue (3%), and dizziness (3%). No patients achieved complete or partial responses and the median progression-free survival was 1.4 months (95% confidence interval, 0.8 to 2.8).
Conclusion
OPB-111077 was well tolerated in patients with advanced HCC after sorafenib failure, but only showed limited preliminary efficacy outcomes. Further investigation of the role of the STAT3 signaling pathway in HCC and the development of biomarkers for STAT3 inhibitors are warranted. -
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Divya Janjua, Kulbhushan Thakur, Nikita Aggarwal, Apoorva Chaudhary, Joni Yadav, Arun Chhokar, Tanya Tripathi, Udit Joshi, Anna Senrung, Alok Chandra Bharti
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Han‐Qi Wang, Qi‐Wen Man, Fang‐Yi Huo, Xin Gao, Hao Lin, Su‐Ran Li, Jing Wang, Fu‐Chuan Su, Lulu Cai,, Yi Shi, Bing Liu,, Lin‐Lin Bu
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Takehiro Hiraoka, Yasushi Hirota, Shizu Aikawa, Rei Iida, Chihiro Ishizawa, Tetsuaki Kaku, Tomoyuki Hirata, Yamato Fukui, Shun Akaeda, Mitsunori Matsuo, Ryoko Shimizu-Hirota, Norihiko Takeda, Yutaka Osuga
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European Journal of Medicinal Chemistry.2021; 216: 113333. CrossRef - NAFLD-Associated HCC: Progress and Opportunities
Daniel Geh, Quentin M Anstee, Helen L Reeves
Journal of Hepatocellular Carcinoma.2021; Volume 8: 223. CrossRef - The therapeutic potential of mitochondrial toxins
Manabu Kawada, Masahide Amemiya, Junjiro Yoshida, Tomokazu Ohishi
The Journal of Antibiotics.2021; 74(10): 696. CrossRef - Advances of Targeted Therapy for Hepatocellular Carcinoma
Mengke Niu, Ming Yi, Ning Li, Kongju Wu, Kongming Wu
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Robert A. Cerulli, Joshua A. Kritzer
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Alessia Virzì, Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger
Cold Spring Harbor Perspectives in Medicine.2020; 10(1): a037366. CrossRef - Quinazoline Ligands Induce Cancer Cell Death through Selective STAT3 Inhibition and G-Quadruplex Stabilization
Jan Jamroskovic, Mara Doimo, Karam Chand, Ikenna Obi, Rajendra Kumar, Kristoffer Brännström, Mattias Hedenström, Rabindra Nath Das, Almaz Akhunzianov, Marco Deiana, Kazutoshi Kasho, Sebastian Sulis Sato, Parham L. Pourbozorgi, James E. Mason, Paolo Medini
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Benedito A. Carneiro, Wafik S. El-Deiry
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Ethan L. Morgan, Andrew Macdonald
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Périne Millot, Carine San, Evangeline Bennana, Baptiste Porte, Nicolas Vignal, Jacques Hugon, Claire Paquet, Benoit Hosten, François Mouton-Liger
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Lara Brambilla, Tanaya Lahiri, Michael Cammer, David E. Levy
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- Targeting JAK2/STAT3 for the treatment of cancer: A review on recent advancements in molecular development using structural analysis and SAR investigations
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- 40 Web of Science
- 39 Crossref
- A Comprehensive Assessment of the Racial and Ethnic Disparities in the Incidence of Gastric Cancer in the United States, 1992-2014
- Qiang Yao, Xiaona Qi, Wen Cheng, Shao-Hua Xie
- Cancer Res Treat. 2019;51(2):519-529. Published online June 19, 2018
- DOI: https://doi.org/10.4143/crt.2018.146
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
This study aimed to evaluate the racial and ethnic disparities in the incidence of gastric cancer and their temporal trends in the United States.
Materials and Methods
Using data from 13 cancer registries in the Surveillance, Epidemiology, and End Results database, we assessed such disparities during 1992-2014 in the United States using a variety of disparity metrics.
Results
The age-standardized incidence rate of non-cardia gastric cancer was highest in Asian and Pacific Islanders, while the incidence of cardia gastric was highest in non-Hispanic whites in men and was similarly low in all groups in women. The incidence of non-cardia gastric cancer decreased in all groups over time, particularly in Asian and Pacific Islanders (on average by 3% per year). The incidence of cardia gastric remained relatively stable in virtually all racial/ethnic groups. The racial and ethnic disparities in gastric cancer incidence steadily decreased over time as measured on the absolute scale, which was mainly driven by the reduced disparities in non-cardia gastric cancer. The range difference in the incidence of gastric cancer decreased on average by 4.1% per year in men and by 2.6% per year in women from 1992 to 2014. The between group variance decreased by 5.6% per year in men and by 3.4% per year in women. The relative-scale disparity measures generally remained stable over time.
Conclusion
This study demonstrates decreased racial and ethnic disparities in the incidence of gastric cancer over time in the United States, particularly as measured on the absolute scale. -
Citations
Citations to this article as recorded by- Stomach Cancer Prediction Model (SCoPM): An approach to risk stratification in a diverse U.S. population
Bechien U. Wu, Elizabeth Y. Dong, Qiaoling Chen, Tiffany Q. Luong, Eva Lustigova, Christie Y. Jeon, Wansu Chen, Hee-Taik Kang
PLOS ONE.2024; 19(5): e0303153. CrossRef - Racial, Ethnic, and Sex Differences in Incidence-Based Mortality of Aggregate Upper Gastrointestinal Cancers
Alyyah Malick, Jennifer S. Ferris, Chin Hur, Julian A. Abrams, Ali Soroush
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Tajul Islam Mamun, Sabrina Younus, Md. Hashibur Rahman
Cancer Treatment and Research Communications.2024; 41: 100845. CrossRef - Racial/ethnic disparities in gastric cancer: A 15‐year population‐based analysis
Maria Gonzalez‐Pons, Carlos R. Torres‐Cintrón, Marievelisse Soto‐Salgado, Yimari Vargas‐Ramos, Luis Perez‐Portocarrero, Douglas R. Morgan, Marcia Cruz‐Correa
Cancer Medicine.2023; 12(2): 1860. CrossRef - The uneven decline of gastric cancer in the USA: epidemiology of a health disparity
Charles S. Rabkin
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Parkes Kendrick, Yekaterina O. Kelly, Mathew M. Baumann, Kelly Compton, Brigette F. Blacker, Farah Daoud, Zhuochen Li, Farah Mouhanna, Hasan Nassereldine, Chris Schmidt, Dillon O. Sylte, Lisa M. Force, Simon I. Hay, Erik J. Rodriquez, George A. Mensah, An
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Gene T. Yoshikawa, Nicholas Simon, Ryon K. Nakasone, Jared D. Acoba
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Yasuo Ohashi, Masataka Ikeda, Hideo Kunitoh, Mitsuru Sasako, Takuji Okusaka, Hirofumi Mukai, Keiichi Fujiwara, Mashio Nakamura, Mari S. Oba, Tetsuya Kimura, Kei Ibusuki, Atsushi Takita, Masato Sakon
Thrombosis Research.2022; 213: 203. CrossRef - Gastric Cancer
Dalton A. Norwood, Eleazar Montalvan-Sanchez, Ricardo L. Dominguez, Douglas R. Morgan
Gastroenterology Clinics of North America.2022; 51(3): 501. CrossRef - Current therapeutic options for gastric adenocarcinoma
C.R. Akshatha, Smitha Bhat, R. Sindhu, Dharini Shashank, Sarana Rose Sommano, Wanaporn Tapingkae, Ratchadawan Cheewangkoon, Shashanka K. Prasad
Saudi Journal of Biological Sciences.2021; 28(9): 5371. CrossRef - The presentation of Hispanic gastric cancer patients varies by location of patient ancestry
John D. Karalis, Michelle R. Ju, John C. Mansour, Patricio M. Polanco, Adam C. Yopp, Herbert J. Zeh, Matthew R. Porembka, Sam C. Wang
Journal of Surgical Oncology.2021; 124(7): 1051. CrossRef - Integrated cancer networks improve compliance with national guidelines and outcomes for resectable gastric cancer
Cornelius A. Thiels, Kristine T. Hanson, Elizabeth B. Habermann, Judy C. Boughey, Travis E. Grotz
Cancer.2020; 126(6): 1283. CrossRef - Disadvantages for non-Hispanic whites in gastric carcinoma survival in Florida
Jingxin Liu, Heidy Medina, Isildinha M. Reis, Daniel A. Sussman, Paulo S. Pinheiro
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Qiang Yao, Xiaona Qi, Shao-Hua Xie
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- Stomach Cancer Prediction Model (SCoPM): An approach to risk stratification in a diverse U.S. population
- 18,785 View
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- 17 Crossref
- Increased Risk of Osteoporosis in Gastric Cancer Survivors Compared to General Population Control: A Study with Representative Korean Population
- Su-Min Jeong, Dong Wook Shin, Ji Eun Lee, Sang-Man Jin, Sung Kim
- Cancer Res Treat. 2019;51(2):530-537. Published online June 27, 2018
- DOI: https://doi.org/10.4143/crt.2018.164
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Although several studies have suggested that osteoporosis is common in survivors of gastric cancer (GC), no study to date has directly assessed the risk for osteoporosis in GC survivors compared to matched controls. Thus, we aimed to investigate the relative risk for osteoporosis in survivors of GC compared to general population.
Materials and Methods
We used the Korea National Health and Nutrition Examination Survey data (2008-2011). Patients with a history of GC (n=94) were defined as case among 8,142 individuals over 50 years old who were evaluated by dual-energy X-ray absorptiometry. Controls (n=470) were matched to cases by age and sex in a 1:5 ratio. Osteopenia (–2.5 < T-score < –1.0) and osteoporosis (T-score ≤ –2.5) were defined.
Results
The prevalence of osteoporosis in GC survivors was 30.2%, which was significantly greater than that of controls (19.7%). In total, GC survivors had a 3.7-fold increased risk for osteoporosis compared to controls (p=0.021). In addition, the risk for osteoporosis of the total proximal femur total (TF) and femur neck (FN) was significantly increased among GC survivors compared to controls (adjusted relative risk, 4.64; 95% confidence interval, 1.16 to 18.6 in TF and adjusted relative risk, 3.58; 95% confidence interval, 1.19 to 10.8 in FN). Furthermore, we found sub-optimal daily calcium intake and mean serum levels of 25-hydroxy-vitamin D in both groups.
Conclusion
GC survivors are at significantly increased risk for osteoporosis, especially in the femur. Clinically, our finding supports the importance of screening bone health and adequate nutrient supplementation in survivors of GC. -
Citations
Citations to this article as recorded by- Senolytic treatment alleviates doxorubicin‐induced chemobrain
Vivekananda Budamagunta, Ashok Kumar, Asha Rani, Sahana Manohar Sindhu, Yang Yang, Daohong Zhou, Thomas C. Foster
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Soomin An, Wankyu Eo
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HyunJin Oh, Byung-Ho Yoon, Jung-Wee Park, Ye Jhin Jeon, Bit-Na Yoo, Jean Kyung Bak, Yong-Chan Ha, Young-Kyun Lee
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Daniela Merlotti, Christian Mingiano, Roberto Valenti, Guido Cavati, Marco Calabrese, Filippo Pirrotta, Simone Bianciardi, Alberto Palazzuoli, Luigi Gennari
International Journal of Molecular Sciences.2022; 23(5): 2713. CrossRef - Vitamin D—The Nutritional Status of Post-Gastrectomy Gastric Cancer Patients—Systematic Review
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Leon Fisher, Alexander Fisher, Paul N Smith
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Dong Wook Shin, Beomseok Suh, Hyunsun Lim, Yun-Suhk Suh, Yoon Jin Choi, Su-Min Jeong, Jae Moon Yun, Sun Ok Song, Youngmin Park
American Journal of Gastroenterology.2019; 114(11): 1735. CrossRef
- Senolytic treatment alleviates doxorubicin‐induced chemobrain
- 8,585 View
- 163 Download
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- 12 Crossref
- Diabetes Medication Use in Association with Survival among Patients of Breast, Colorectal, Lung, or Gastric Cancer
- Michelle L. Baglia, Yong Cui, Tao Zheng, Gong Yang, Honglan Li, Mingrong You, Liling Xu, Harvey Murff, Yu-Tang Gao, Wei Zheng, Yong-Bing Xiang, Xiao-Ou Shu
- Cancer Res Treat. 2019;51(2):538-546. Published online July 2, 2018
- DOI: https://doi.org/10.4143/crt.2017.591
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Studies suggest that regular use of metformin may decrease cancer mortality. We investigated the association between diabetes medication use and cancer survival.
Materials and Methods
The current study includes 633 breast, 890 colorectal, 824 lung, and 543 gastric cancer cases identified from participants of two population-based cohort studies in Shanghai. Information on diabetes medication use was obtained by linking to electronic medical records. The associations between diabetes medication use (metformin, sulfonylureas, and insulin) and overall and cancer-specific survival were evaluated using time-dependent Cox proportional hazards models.
Results
After adjustment for clinical characteristics and treatment factors, use of metformin was associated with better overall survival among colorectal cancer patients (hazards ratio [HR], 0.55; 95% confidence interval [CI], 0.34 to 0.88) and for all four types of cancer combined (HR, 0.75; 95% CI, 0.57 to 0.98). Ever use of insulin was associated with worse survival for all cancer types combined (HR, 1.89; 95% CI, 1.57 to 2.29) and for the four cancer types individually. Similar associations were seen for diabetic patients. Sulfonylureas use was associated with worse overall survival for breast or gastric cancer (HR, 2.87; 95% CI, 1.22 to 6.80 and HR, 2.05; 95% CI, 1.09 to 3.84, respectively) among diabetic patients. Similar association patterns were observed between diabetes medication use and cancer-specific survival.
Conclusion
Metformin was associated with improved survival among colorectal cancer cases, while insulin use was associated with worse survival among patients of four major cancers. Further investigation on the topic is needed given the potential translational impact of these findings. -
Citations
Citations to this article as recorded by- Effect of Metformin Use on Survival and Recurrence Rate of Gastric Cancer After Gastrectomy in Diabetic Patients: A Systematic Review and Meta-analysis of Observational Studies
Mansour Bahardoust, Safa Mousavi, Zahra Deylami Moezi, Mohsen Yarali, Ali Tayebi, Faranak Olamaeian, Adnan Tizmaghz
Journal of Gastrointestinal Cancer.2024; 55(1): 65. CrossRef - Antidiabetic Drugs in Breast Cancer Patients
Wojciech Garczorz, Agnieszka Kosowska, Tomasz Francuz
Cancers.2024; 16(2): 299. CrossRef - Association of metformin and statin uses with the prognosis of colon cancer: a meta-analysis
Yanyan Xu, Hao Che, Jiang Liu, Pingjiang Ye
European Journal of Cancer Prevention.2024; 33(5): 414. CrossRef - Metformin in combination with chemotherapy increases apoptosis in gastric cancer cells and counteracts senescence induced by chemotherapy
Katia Vázquez‑Ibarra, Josefina Sánchez López, Tomás Pineda Razo, José Cruz Lozano, Brenda Ortiz‑Tamayo, Luis Palafox‑Mariscal, Rosa González Arreola, Juan González‑García, Pablo Ortiz-Lazareno
Oncology Letters.2024;[Epub] CrossRef - A Mathematical Model of the Disruption of Glucose Homeostasis in Cancer Patients
Noah Salentine, Jonathan Doria, Chinh Nguyen, Gabriella Pinter, Shizhen Emily Wang, Peter Hinow
Bulletin of Mathematical Biology.2023;[Epub] CrossRef - Effect of Metformin on the Prognosis of Gastric Cancer Patients with Type 2 Diabetes Mellitus: A Meta-Analysis Based on Retrospective Cohort Studies
Lingna Li, Jianing Huang, Tongmin Huang, Jie Yao, Yeyuan Zhang, Meiling Chen, Haojie Shentu, Haiying Lou, Flavia Prodam
International Journal of Endocrinology.2023; 2023: 1. CrossRef - Shared Lifestyle-Related Risk Factors of Cardiovascular Disease and Cancer: Evidence for Joint Prevention
Farzad Masoudkabir, Noushin Mohammadifard, Arya Mani, Andrew Ignaszewski, Margot K. Davis, Golnaz Vaseghi, Marjan Mansourian, Christopher Franco, Carolyn Gotay, Nizal Sarrafzadegan, Francesco Giallauria
The Scientific World Journal.2023; 2023: 1. CrossRef - Diabetes Mellitus and Gastric Cancer: Correlation and Potential Mechanisms
Li Wang, Zhe Zhang, Eusebio Chiefari
Journal of Diabetes Research.2023; 2023: 1. CrossRef - Perspectives of metformin use in endometrial cancer and other gynaecological malignancies
Bartłomiej Barczyński, Karolina Frąszczak, Jan Kotarski
Journal of Drug Targeting.2022; 30(4): 359. CrossRef - Type 2 Diabetes and all-cause mortality among Spanish women with breast cancer
L. Fernández-Arce, N. Robles-Rodríguez, A. Fernández-Feito, A. Llaneza-Folgueras, A. I. Encinas-Muñiz, A. Lana
Cancer Causes & Control.2022; 33(2): 271. CrossRef - Diabetes and Colorectal Cancer Risk: Clinical and Therapeutic Implications
Guan-Hua Yu, Shuo-Feng Li, Ran Wei, Zheng Jiang, Eusebio Chiefari
Journal of Diabetes Research.2022; 2022: 1. CrossRef - Systemic Evaluation of the Effect of Diabetes Mellitus on Breast Cancer in a Mouse Model
Nana Wei, Jinmiao Lu, Zhibing Lin, Xiaoyu Wang, Mengmeng Cai, Shengyao Jiang, Xiaoyu Chen, Shilan Zhu, Dong Zhang, Li Cui
Frontiers in Oncology.2022;[Epub] CrossRef - The Association of Metformin, Other Antidiabetic Medications and Statins on the Prognosis of Rectal Cancer in Patients with Type 2 Diabetes: A Retrospective Cohort Study
Sami Erkinantti, Ari Hautakoski, Reijo Sund, Martti Arffman, Elina Urpilainen, Ulla Puistola, Esa Läärä, Arja Jukkola, Peeter Karihtala
Biomolecules.2022; 12(9): 1301. CrossRef - Metformin protects against diabetes-induced heart injury and dunning prostate cancer model
BB Bayrak, P Koroglu, O Karabulut Bulan, R Yanardag
Human & Experimental Toxicology.2021; 40(2): 297. CrossRef - Pharmacological inhibition of tumor anabolism and host catabolism as a cancer therapy
Alejandro Schcolnik-Cabrera, Alma Chavez-Blanco, Guadalupe Dominguez-Gomez, Mandy Juarez, Ariana Vargas-Castillo, Rafael Isaac Ponce-Toledo, Donna Lai, Sheng Hua, Armando R. Tovar, Nimbe Torres, Delia Perez-Montiel, Jose Diaz-Chavez, Alfonso Duenas-Gonzal
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Ademar Dantas Cunha Júnior, Arinilda Campos Bragagnoli, Felipe Osório Costa, José Barreto Campello Carvalheira
World Journal of Gastroenterology.2021; 27(17): 1883. CrossRef - Improved prognosis in gastric adenocarcinoma among metformin users in a population-based study
Jiaojiao Zheng, Giola Santoni, Shao-Hua Xie, Jesper Lagergren
British Journal of Cancer.2021; 125(2): 277. CrossRef - The Relationship between Diabetes Mellitus and Gastric Cancer and the Potential Benefits of Metformin: An Extensive Review of the Literature
Chin-Hsiao Tseng
Biomolecules.2021; 11(7): 1022. CrossRef - Potential intrinsic subtype dependence on the association between metformin use and survival in surgically resected breast cancer: a Korean national population-based study
Byoung Hyuck Kim, Moon-June Cho, Jeanny Kwon
International Journal of Clinical Oncology.2021; 26(11): 2004. CrossRef - Progress in understanding of relationship between diabetes and colorectal cancer
Guan-Hua Yu, Zheng Jiang
World Chinese Journal of Digestology.2021; 29(23): 1323. CrossRef - The effect of metformin on gastric cancer in patients with type 2 diabetes: a systematic review and meta-analysis
Y. Shuai, C. Li, X. Zhou
Clinical and Translational Oncology.2020; 22(9): 1580. CrossRef - The right place for metformin today
Guntram Schernthaner, Gerit-Holger Schernthaner
Diabetes Research and Clinical Practice.2020; 159: 107946. CrossRef - Suppressive effects of metformin on colorectal adenoma incidence and malignant progression
Min Deng, Siqin Lei, Dongdong Huang, Hui Wang, Shuli Xia, Enping Xu, Yihua Wu, Honghe Zhang
Pathology - Research and Practice.2020; 216(2): 152775. CrossRef Preventative and Therapeutic Effects of Metformin in Gastric Cancer: A New Contribution of an Old Friend
Jing Zhang, Liping Wen, Quan Zhou, Kuifeng He, Lisong Teng
Cancer Management and Research.2020; Volume 12: 8545. CrossRef- Does Roux-en-Y Construction Really Bring Benefit of Type 2 Diabetes Mellitus Remission After Gastrectomy in Patients with Gastric Cancer? A Systematic Review and Meta-Analysis
Dong Peng, Yu-Xi Cheng, Wei Zhang
Diabetes Therapy.2020; 11(12): 2863. CrossRef - Prognosis of Patients with Colorectal Cancer with Diabetes According to Medication Adherence: A Population-Based Cohort Study
Sunho Choe, Joonki Lee, Ji Won Park, Seung-Yong Jeong, Young Min Cho, Byung-Joo Park, Aesun Shin
Cancer Epidemiology, Biomarkers & Prevention.2020; 29(6): 1120. CrossRef - The combination of orlistat, lonidamine and 6‑diazo‑5‑oxo‑L‑norleucine induces a quiescent energetic phenotype and limits substrate flexibility in colon cancer cells
Alejandro Schcolnik‑Cabrera, Alma Chavez‑Blanco, Guadalupe Dominguez‑Gomez, Mandy Juarez, Donna Lai, Sheng Hua, Armando Tovar, Jose Diaz‑Chavez, Alfonso Duenas‑Gonzalez
Oncology Letters.2020; 20(3): 3053. CrossRef - Diabetes Mellitus and Colon Carcinogenesis: Expectation for Inhibition of Colon Carcinogenesis by Oral Hypoglycemic Drugs
Junichi Kato, Yohei Shirakami, Masahito Shimizu
Gastrointestinal Disorders.2019; 1(2): 273. CrossRef - Use of Antihypertensive Medications and Survival Rates for Breast, Colorectal, Lung, or Stomach Cancer
Yong Cui, Wanqing Wen, Tao Zheng, Honglan Li, Yu-Tang Gao, Hui Cai, Mingrong You, Jing Gao, Gong Yang, Wei Zheng, Yong-Bing Xiang, Xiao-Ou Shu
American Journal of Epidemiology.2019; 188(8): 1512. CrossRef - Effects of propofol and sevoflurane on blood glucose, hemodynamics, and inflammatory factors of patients with type�2 diabetes mellitus and gastric cancer
Jinhui Liu, Li Yang
Oncology Letters.2019;[Epub] CrossRef - A cohort study of antihyperglycemic medication exposure and survival in patients with gastric cancer
Audrius Dulskas, Ausvydas Patasius, Donata Linkeviciute-Ulinskiene, Lina Zabuliene, Giedre Smailyte
Aging.2019; 11(17): 7197. CrossRef
- Effect of Metformin Use on Survival and Recurrence Rate of Gastric Cancer After Gastrectomy in Diabetic Patients: A Systematic Review and Meta-analysis of Observational Studies
- 10,531 View
- 263 Download
- 37 Web of Science
- 31 Crossref
- Radiation Therapy Outcome and Clinical Features of Duodenal-Type Follicular Lymphoma
- Hansang Lee, Dongryul Oh, Kyungmi Yang, Young Hyeh Ko, Yong Chan Ahn, Won Seog Kim, Seok Jin Kim
- Cancer Res Treat. 2019;51(2):547-555. Published online July 10, 2018
- DOI: https://doi.org/10.4143/crt.2018.190
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Duodenal-type follicular lymphoma (FL) is a rare variant of FL. There is still no consensus on the initial treatment, and clinical features including endoscopic findings are not familiar to most physicians. The objective of this study was to evaluate the outcome of patients who were initially treated with radiation therapy for duodenal-type FL.
Materials and Methods
We retrospectively analyzed 20 patients who were consecutively diagnosed with duodenaltype FL between 2008 and 2017. All patients received radiation therapywith curative intent.
Results
The median age of the patients was 52 years (range, 26 to 66 years), and females were predominant. Most patients (n=18, 90%) had stage I disease, and were diagnosed by a regular health examination in an asymptomatic state. The histological grade was one in 19 patients (95%), and the endoscopic findings were diffuse nodular (n=8), whitish granular (n=8), and mixed pattern (n=4). Radiation therapy was delivered to 17 patients with 24 Gy in 12 fractions, and to three patients with 30.6-36 Gy in 18 fractions. All patients were evaluated with endoscopy for response to radiation therapy, and complete response was achieved in 19 patients (95%). At the time of analysis, all patients survived without any evidence of late toxicities related with radiation therapy.
Conclusion
Taken together, radiation therapy alone could be effective in controlling duodenal lesion. A further study with longer follow-up duration is warranted to confirm our findings. -
Citations
Citations to this article as recorded by- Recent updates on treatment options for primary follicular lymphoma of the gastrointestinal tract
Masaya Iwamuro, Takehiro Tanaka, Daisuke Ennishi, Motoyuki Otsuka
Expert Review of Gastroenterology & Hepatology.2024; 18(7): 367. CrossRef - Duodenal-type follicular lymphoma: comprehensive insights into disease characteristics and established treatment strategies
Ahmed Alnughmush, Riad El Fakih, Ruah Alyamany, Nasir Bakshi, Saud Alhayli, Mahmoud Aljurf
Current Opinion in Oncology.2024; 36(6): 577. CrossRef - Clinical characteristics and outcomes of Brazilian patients with duodenal-type follicular lymphoma: a multicenter retrospective study
Guilherme Duffles, Arthur Braga, Talita Silveira, Yana Novis, Celso Arrais, Luciana Tucunduva, Ana Rita Fonseca, Davimar Borducchi, Pedro Neffa, Fernando Blumm, Marianne de Castro Gonçalves, Frederico Moreira, Fabio Nucci, Eduardo Rego, Vanderson Rocha
Leukemia & Lymphoma.2024; : 1. CrossRef - Bridging clinicopathologic features and genetics in follicular lymphoma: Towards enhanced diagnostic accuracy and subtype differentiation
Jan Bosch-Schips, Xenia Parisi, Fina Climent, Francisco Vega
Human Pathology.2024; : 105676. CrossRef - Duodenal Polyposis: An Incidental Finding of Duodenal-Type Follicular Lymphoma
Rachael Hagen, Jasmine Tidwell, Emily Weng, Steven A Goldenberg, Anjiya Shaikh
Cureus.2024;[Epub] CrossRef - Increased Risk of Diabetes after Definitive Radiotherapy in Patients with Indolent Gastroduodenal Lymphoma
Jong Yun Baek, Do Hoon Lim, Dongryul Oh, Heerim Nam, Jae J Kim, Jun Haeng Lee, Byung-Hoon Min, Hyuk Lee
Cancer Research and Treatment.2022; 54(1): 294. CrossRef - Duodenal Follicular Lymphoma: Track or Treat?
M. Varanese, A. Lauro, I. Lattina, D. Tripodi, T. Daralioti, S. Khouzam, I. R. Marino, V. Stigliano, V. D’Andrea, S. Frattaroli, S. Sorrenti
Digestive Diseases and Sciences.2022; 67(5): 1733. CrossRef - Incidentally Found Mucosal Nodularity on the Second Portion of Duodenum
Joo Hyun Lim
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2022; 22(2): 163. CrossRef - Duodenal-type follicular lymphoma more than 10 years after treatment intervention: A retrospective single-center analysis
Makoto Saito, Akio Mori, Shihori Tsukamoto, Takashi Ishio, Emi Yokoyama, Koh Izumiyama, Masanobu Morioka, Takeshi Kondo, Hirokazu Sugino
World Journal of Gastrointestinal Oncology.2022; 14(8): 1552. CrossRef - Linfoma folicular duodenal primario: reporte de caso y revisión de la literatura
Lázaro Antonio Arango Molano, Andrés Sánchez Gil, Ileana Rocío Bautista Parada
Revista colombiana de Gastroenterología.2021; 36(4): 525. CrossRef - What do we know about duodenal‐type follicular lymphoma? From pathological definition to treatment options
Guilherme Duffles Amarante, Graham Collins, Vanderson Rocha
British Journal of Haematology.2020; 188(6): 831. CrossRef - Scientific Advances and the Evolution of Diagnosis, Subclassification and Treatment of Lymphoma
Judith A. Ferry
Archives of Medical Research.2020; 51(8): 749. CrossRef - Development of diffuse large B-cell lymphoma from duodenal type follicular lymphoma: a retrospective study of 23 cases
Masuho Saburi, Yoshiyuki Kondo, Masao Ogata, Yasuhiro Soga, Miyuki Abe, Kuniko Takano, Kazuhiro Kohno, Takayuki Nagai, Toshiyuki Nakayama
International Journal of Hematology.2020; 112(5): 658. CrossRef - Analysis of the response time to involved-field radiotherapy in primary gastrointestinal low-grade B-cell lymphoma
Kyu Hye Choi, Han Hee Lee, Seung-Eun Jung, Kyung-Sin Park, Joo-Hyun O, Young-Woo Jeon, Byung-Ock Choi, Seok-Goo Cho
Radiation Oncology.2020;[Epub] CrossRef
- Recent updates on treatment options for primary follicular lymphoma of the gastrointestinal tract
- 11,446 View
- 267 Download
- 11 Web of Science
- 14 Crossref
- Health-Related Quality of Life Changes in Prostate Cancer Patients after Radical Prostatectomy: A Longitudinal Cohort Study
- Dong Wook Shin, Sang Hyub Lee, Tae-Hwan Kim, Seok Joong Yun, Jong Kil Nam, Seung Hyun Jeon, Seung Chol Park, Seung Il Jung, Jong-Hyock Park, Jinsung Park
- Cancer Res Treat. 2019;51(2):556-567. Published online July 16, 2018
- DOI: https://doi.org/10.4143/crt.2018.221
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Health-related quality of life (HRQOL) information related to radical prostatectomy (RP) is valuable for prostate cancer (PC) patients needing to make treatment decisions. We aimed to investigate HRQOL change in PC patients who underwent three types of RP (open, laparoscopic, or robotic) and compared their HRQOL with that of general population.
Materials and Methods
Patients were prospectively recruited between October 2014 and December 2015. European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire (EORTC QLQ-C30) and PC-specific module (PR25) were administered before surgery (baseline) and at postoperative 3 and 12 months. At each time point, HRQOL was compared, and a difference of 10 out of 0-100 scale was considered clinically significant.
Results
Among 258 screened patients, 209 (41 open, 63 laparoscopic, and 105 robotic surgeries) were included. Compared to baseline, physical, emotional, and cognitive functioning improved at 12 months. Role functioning worsened at 3 months, but recovered to baseline at 12 months. Pain, insomnia, diarrhea, and financial difficulties also significantly improved at 12 months. Most PR25 scales excluding bowel symptoms deteriorated at 3 months. Urinary symptoms and incontinence aid recovered at 12 months, whereas sexual activity and sexual function remained poor at 12 months. Clinically meaningful differences in HRQOL were not observed according to RP modalities. Compared to the general population, physical and role functioning were significantly lower at 3 months, but recovered by 12 months. Social functioning did not recover.
Conclusion
Most HRQOL domains showed recovery within 12 months after RP, excluding sexual functioning and social functioning. Our findings may guide patients considering surgical treatment for PC. -
Citations
Citations to this article as recorded by- Quality of life after robotic versus conventional minimally invasive cancer surgery: a systematic review and meta-analysis
Russell Seth Martins, Asad Saulat Fatimi, Omar Mahmud, Muhammad Umar Mahar, Arshia Jahangir, Kinza Jawed, Shalni Golani, Ayra Siddiqui, Syed Roohan Aamir, Ali Ahmad
Journal of Robotic Surgery.2024;[Epub] CrossRef - The Effect of Discharge Education and Post-Discharge Telephone Counseling on Quality of Life in Patients Undergoing Radical Prostatectomy: A Randomized Controlled Study
İpek Köse Tosunöz, Sevgi Deniz Doğan, Şeyma Yurtseven, Sevban Arslan
Cukurova Anestezi ve Cerrahi Bilimler Dergisi.2024; 7(3): 205. CrossRef - Health‐related quality of life the first year after a prostate cancer diagnosis a systematic review
Louise Dorner Østergaard, Mads Hvid Poulsen, Malene Eiberg Jensen, Lars Lund, Malene Grubbe Hildebrandt, Birgitte Nørgaard
International Journal of Urological Nursing.2023; 17(1): 15. CrossRef - Quantitative Analysis of Quality of Life and Exploration of Influencing Factors in Patients Undergoing Radical Prostatectomy
Feiyang Wang, Jiajun Chen, Weihao Wang, Mengyao Li, Chao Peng, Shouhua Pan, Chuanchuan Zhan, Keyuan Zhao, Yulei Li, Lulu Zhang, Gang Xu, Jing Jin
Urology.2023; 181: 105. CrossRef - Effects of omega‐3 supplementation on psychological symptoms in men with prostate cancer: Secondary analysis of a double‐blind placebo‐controlled randomized trial
Josée Savard, Hanane Moussa, Jean‐François Pelletier, Pierre Julien, Louis Lacombe, Rabi Tiguert, Yves Caumartin, Thierry Dujardin, Paul Toren, Frédéric Pouliot, Michele Lodde, Yves Fradet, Karine Robitaille, Vincent Fradet
Cancer Medicine.2023; 12(19): 20163. CrossRef - Treatment Outcomes and Its Associated Factors Among Adult Patients with Selected Solid Malignancies at Kenyatta National Hospital: A Hospital-Based Prospective Cohort Study
Amsalu Degu, Ermias Mergia Terefe, Eliab Seroney Some, Gobezie T Tegegne
Cancer Management and Research.2022; Volume 14: 1525. CrossRef - A systematic review of supervised comprehensive functional physiotherapy after radical prostatectomy
B. Steenstrup, M. Cartier, F.X. Nouhaud, G. Kerdelhue, M. Gilliaux
Progrès en Urologie.2022; 32(7): 525. CrossRef - Perioperative psychological issues and nursing care among patients undergoing minimally invasive surgeries
Kehua Yang, Xu Shao, Xinghui Lv, Feimin Yang, Qunyan Shen, Jing Fang, Wei Chen
Laparoscopic, Endoscopic and Robotic Surgery.2022; 5(3): 92. CrossRef - A Survey on the Quality of Life of Prostate Cancer Patients in Korean Prostate Cancer Patients Association
Yun-Sok Ha, Kwang Taek Kim, Wook Nam, Hongzoo Park, Sangjun Yoo, Chan Ho Lee, Ho Seok Chung, Woo Suk Choi, Jiyoun Kim, Jaeeun Shin, Jeong Hyun Kim, Cheol Kwak
The Korean Journal of Urological Oncology.2022; 20(4): 265. CrossRef - Effects of leuprolide acetate on the quality of life of patients with prostate cancer: A prospective longitudinal cohort study
Myung Soo Kim, Seung Il Jung, Ho Seok Chung, Eu Chang Hwang, Dongdeuk Kwon
Prostate International.2021; 9(3): 132. CrossRef - Quality of life assessment using EORTC QLQ questionnaires in the prostate cancer population treated with radical prostatectomy: a systematic review
Tomasz Jurys, Jacek Durmala
Scandinavian Journal of Urology.2021; 55(2): 90. CrossRef - Évaluation de l’observance et de l’adhésion thérapeutique de deux protocoles de rééducation après prostatectomie
Benoit Steenstrup, Claire Breton, Guillaume Galliou, François-Xavier Nouhaud
Kinésithérapie, la Revue.2021; 21(234): 12. CrossRef - Metabolic syndrome, levels of androgens, and changes of erectile dysfunction and quality of life impairment 1 year after radical prostatectomy
Yann Neuzillet, Mathieu Rouanne, Jean-François Dreyfus, Jean-Pierre Raynaud, Marc Schneider, Morgan Roupret, Sarah Drouin, Marc Galiano, Xavier Cathelinau, Thierry Lebret, Henry Botto
Asian Journal of Andrology.2021; 23(4): 370. CrossRef - The Effect of Post-prostatectomy Urinary Incontinence on Health-related Quality of Life in Patients with Prostate Cancer
Jeong Hyun Kim, Yeon Soo Jang, Young Deuk Choi, Eui Geum Oh
Korean Journal of Adult Nursing.2019; 31(3): 293. CrossRef - Prostate-specific health-related quality of life and patient-physician communication — A 3.5-year follow-up
Nicole Ernstmann, Jan Herden, Lothar Weissbach, André Karger, Kira Hower, Lena Ansmann
Patient Education and Counseling.2019; 102(11): 2114. CrossRef
- Quality of life after robotic versus conventional minimally invasive cancer surgery: a systematic review and meta-analysis
- 9,954 View
- 292 Download
- 14 Web of Science
- 15 Crossref
- Verification of Low Risk for Perihippocampal Recurrence in Patients with Brain Metastases Who Received Whole-Brain Radiotherapy with Hippocampal Avoidance
- Youngkyong Kim, Sung Hwan Kim, Jong Hoon Lee, Dae Gyu Kang
- Cancer Res Treat. 2019;51(2):568-575. Published online July 16, 2018
- DOI: https://doi.org/10.4143/crt.2018.206
-
Abstract
PDFPubReaderePub
- Purpose
The purpose of this study was to analyze the patterns of failure and survival outcome in patients with brain metastases who received whole-brain radiotherapy (WBRT) with hippocampal avoidance (HA) using simultaneous integrated boost (SIB) on metastatic brain tumors.
Materials and Methods
We retrospectively reviewed 42 patients treated with HA-WBRT for brain metastases. A total of 25 Gy for whole brain and 35-55 Gy for gross tumors were delivered with 10 fractionations. Local tumor and intracranial progression were defined as a recurrence or tumor progression in SIB field and any recurrence or tumor progression within whole brain, respectively. Progression in HA zone was defined as the recurrence within the area expanded 5 mm from HA zone.
Results
Median follow-up duration was 10.0 months (range, 4.1 to 56.4 months). Intracranial progression was observed in 13 patients (31.0%) and the median duration from the start of HA-WBRT to progression was 10.6 months (range, 0.9 to 33.0 months). Local tumor progression and new metastasis outside SIB field occurred in 10 patients (23.8%) and nine patients (21.4%), respectively. There was no isolated hippocampal metastasis, except only one patient (2.4%) with multiple metastases inside and outside HA zone simultaneously. Median survival time and intracranial progression-free survival rate at 1 year were 19.4 months (95% confidence interval [CI], 9.6 to 29.2) and 71.5%, respectively, and those for overall survival were 26.5 months (95% CI, 15.4 to 37.5) and 67.9%, respectively.
Conclusion
HA-WBRT was associated with low risk of new metastasis in HA region in the patients with brain metastases. These findings would serve as useful guidance on applying HA-WBRT in clinical practice. -
Citations
Citations to this article as recorded by- Incidence of hippocampal and perihippocampal brain metastases and impact on hippocampal-avoiding radiotherapy: A systematic review and meta-analysis
Shari Wiegreffe, Gustavo Renato Sarria, Julian Philipp Layer, Egon Dejonckheere, Younèss Nour, Frederic Carsten Schmeel, Frank Anton Giordano, Leonard Christopher Schmeel, Ilinca Popp, Anca-Ligia Grosu, Eleni Gkika, Cas Stefaan Dejonckheere
Radiotherapy and Oncology.2024; 197: 110331. CrossRef - Recommendation for the contouring of limbic system in patients receiving radiation treatment: A pictorial review for the everyday practice and education
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- 5 Crossref
- Upregulation of PITX2 Promotes Letrozole Resistance Via Transcriptional Activation of IFITM1 Signaling in Breast Cancer Cells
- Ying-ying Xu, Hai-ru Yu, Jia-yi Sun, Zhao Zhao, Shuang Li, Xin-feng Zhang, Zhi-xuan Liao, Ming-ke Cui, Juan Li, Chan Li, Qiang Zhang
- Cancer Res Treat. 2019;51(2):576-592. Published online July 18, 2018
- DOI: https://doi.org/10.4143/crt.2018.100
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Although the interferon α (IFNα) signaling and the paired-like homeodomain transcription factor 2 (PITX2) have both been implicated in the progression of breast cancer (BCa), it remains obscure whether these two pathways act in a coordinated manner. We therefore aimed to elucidate the expression and function of PITX2 during the pathogenesis of endocrine resistance in BCa.
Materials and Methods
PITX2 expression was assessed in BCa tissues using quantitative reverse transcription polymerase chain reaction (RT-qPCR) and immunohistochemistry and in experimentally induced letrozole-resistant BCa cells using RT-qPCR and immunoblotting. Effects of PITX2 deregulation on BCa progression was determined by assessing MTT, apoptosis and xenograft model. Finally, using multiple assays, the transcriptional regulation of interferon-inducible transmembrane protein 1 (IFITM1) by PITX2 was studied at both molecular and functional levels.
Results
PITX2 expression was induced in letrozole-resistant BCa tissues and cells, and PITX2 induction by IFNα signaling powerfully protected BCa cells against letrozole insult and potentiated letrozole-resistance. Mechanistically, PITX2 enhanced IFNα-induced AKT activation by transactivating the transcription of IFITM1, thus rendering BCa cells unresponsive to letrozoleelicited cell death. Additionally, ablation of IFITM1 expression using siRNA substantially abolished IFNα-elicited AKT phosphorylation, even in the presence of PITX2 overexpression, thus sensitizing BCa cells to letrozole treatment.
Conclusion
These results demonstrate that constitutive upregulation of PITX2/IFITM1 cascade is an intrinsic adaptive mechanism during the pathogenesis of letrozole-resistance, and modulation of PITX2/IFITM1 level using different genetic and pharmacological means would thus have a novel therapeutic potential against letrozole resistance in BCa. -
Citations
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PROTEOMICS.2024;[Epub] CrossRef - The role and mechanism of IFITM1 in developing acquired cisplatin resistance in small cell lung cancer
Xuemei Wang, Haihong Qian, Ling Yang, Shuangli Yan, Hua Wang, Xiu Li, Donghai Yang
Heliyon.2024; 10(10): e30806. CrossRef - PITX2 functions as a transcription factor for GPX4 and protects pancreatic cancer cells from ferroptosis
Zhiliang Wang, Di Wu, Yue Zhang, Weibo Chen, Yang Yang, Yue Yang, Guangchen Zu, Yong An, Xianjun Yu, Yi Qin, Xiaowu Xu, Xuemin Chen
Experimental Cell Research.2024; 439(1): 114074. CrossRef - Chronic prostatitis/chronic pelvic pain syndrome impairs erectile function by inducing apoptosis in a rat model of experimental autoimmune prostatitis
Qi Gu, Jiaochen Luan, Mengchi Yu, Jiadong Xia, Zengjun Wang
International Journal of Impotence Research.2024;[Epub] CrossRef - Unveiling stem-like traits and chemoresistance mechanisms in ovarian cancer cells through the TGFβ1-PITX2A/B signaling axis
Sampurna Ghosh, Sk. Eashayan Tanbir, Tulika Mitra, Sib Sankar Roy
Biochemistry and Cell Biology.2024;[Epub] CrossRef - Oncogene‐mediated nuclear accumulation of lactate promotes epigenetic alterations to induce cancer cell proliferation
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Chenlu Wu, Jiafei Ying, Mei Dai, Jing Peng, Danhua Zhang
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Zining Liu, Weili Zhang, Biao Zhang, Shaomu Chen, Chunhua Ling
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Olivia K. Provance, Eric S. Geanes, Asona J. Lui, Anuradha Roy, Sean M. Holloran, Sumedha Gunewardena, Christy R. Hagan, Scott Weir, Joan Lewis-Wambi
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- Correlation of Androgen Deprivation Therapy with Cognitive Dysfunction in Patients with Prostate Cancer: A Nationwide Population-Based Study Using the National Health Insurance Service Database
- Bum Sik Tae, Byung Jo Jeon, Seung Hun Shin, Hoon Choi, Jae Hyun Bae, Jae Young Park
- Cancer Res Treat. 2019;51(2):593-602. Published online July 18, 2018
- DOI: https://doi.org/10.4143/crt.2018.119
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
The purpose of this study was to evaluate the association of androgen deprivation therapy (ADT) with cognitive dysfunction.
Materials and Methods
Using the National Health Insurance Service database of the entire Korean adult prostate cancer population (n=236,391), data on ADT and cognitive dysfunction between 2008 and 2015 were analyzed. We excluded patients previously diagnosed with cognitive dysfunction, dementia, or a cerebral event history. We tested the effect of ADT on the risk of cognitive dysfunction using propensity score–matched Cox proportional hazards regression models and Kaplan-Meier survival analysis. Our final cohort comprised of 35,401 individuals with prostate cancer, including 24,567 men (70.6%) who underwent ADT.
Results
During a mean follow-up period of 4.1 years, 4,741 patients were newly diagnosed with cognitive dysfunction. A statistically significant association was found between ADT and the risk of cognitive dysfunction (hazard ratio, 1.169; p=0.002). Meanwhile, age (≥ 70 years), diabetes, hypertension, cardiovascular history, and peripheral vascular disease were identified as factors that contribute to the increased risk of cognitive dysfunction. In contrast, the use of statins and aspirin was associated with a lower risk of cognitive dysfunction. Kaplan-Meier analysis demonstrated that patients aged 70 years or older who underwent ADT had the lowest cumulative probability of remaining cognitive dysfunction-free (log-rank p < 0.001).
Conclusion
Our results revealed an association between the use of ADT for the treatment of prostate cancer and an increased risk of cognitive dysfunction in a nationwide population-based study. This finding should be further evaluated in prospective studies. -
Citations
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Cancers.2023; 15(10): 2739. CrossRef - Androgen deprivation therapy and risk of cognitive dysfunction in men with prostate cancer: is there a possible link?
Myungsun Shim, Woo Jin Bang, Cheol Young Oh, Yong Seong Lee, Jin Seon Cho
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Charles Ryan, Jeffrey S. Wefel, Alicia K. Morgans
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- Feasibility of Selective Neck Irradiation with Lower Elective Radiation Dose in Treating Nasopharynx Cancer Patients
- Won Kyung Cho, Dongryul Oh, Eonju Lee, Tae Gyu Kim, Hyebin Lee, Heerim Nam, Jae Myoung Noh, Yong Chan Ahn
- Cancer Res Treat. 2019;51(2):603-610. Published online July 18, 2018
- DOI: https://doi.org/10.4143/crt.2018.240
-
Abstract
PDFPubReaderePub
- Purpose
This study aimed to report the clinical outcomes following selective neck irradiation (SNI) with lower elective radiation therapy (RT) dose in treating nasopharyngeal cancer (NPC) patients.
Materials and Methods
A total of 347 NPC patients received definitive RT according to our SNI policy and were retrospectively analyzed. The clinical target volumes (CTVs) were subdivided into CTV at high risk (CTV-HR) and CTV at low risk (CTV-LR). The typical doses to gross tumor volume (GTV), CTV-HR, and CTV-LR were 68.4-70.0 Gy, 54.0-60.0 Gy, and 36.0 Gy.
Results
With the median follow-up of 68.1 months (range, 2.3 to 197.1 months), the 5-year rates of loco-regional control and progression-free survival in all the patients were 85.0% and 70.8%, respectively. Thirty patients developed regional failure and the regional control rates at 3 and 5 years were 92.6% and 91.4%, respectively. The sites of regional failure in relation to the target volume were exclusively inside GTV/CTV-HR in 20, inside and outside GTV/CTVHR in three, and exclusively outside GTV/CTV-HR in seven, which were 5.7%, 0.9%, and 2.0% of total patients, respectively.
Conclusion
The clinical outcomes by the current SNI policy were feasible and comparable to those following classic elective nodal irradiation policy. -
Citations
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- 20 Crossref
- Comparison of Efficacy of Pembrolizumab between Epstein-Barr Virus‒Positive and ‒Negative Relapsed or Refractory Non-Hodgkin Lymphomas
- Seok-Jin Kim, Jiyeon Hyeon, Inju Cho, Young Hyeh Ko, Won Seog Kim
- Cancer Res Treat. 2019;51(2):611-622. Published online July 20, 2018
- DOI: https://doi.org/10.4143/crt.2018.191
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Pembrolizumab, a programmed cell death protein 1 (PD1) inhibitor inhibits the interplay between PD1 of T-cell and programmed cell death ligand 1 (PDL1) on tumor cells. Although pembrolizumab has been tried to various subtypes of non-Hodgkin lymphoma (NHL), realworld data about the efficacy of pembrolizumab in NHL patients are limited.
Materials and methods
We analyzed the outcome of 30 relapsed or refractory NHL patients treated with pembrolizumab, and compared the outcome between Epstein-Barr virus (EBV)‒positive and negative subtypes because EBV infection of tumor cells can upregulate PDL1 expression.
Results
Seven patients with EBV-positive NHL showed a response including NK/T-cell lymphoma (6/14, 44%) and primary mediastinal B-cell lymphoma (1/4, 25%) whereas EBV-negative subtypes did not respond such as diffuse large B-cell lymphoma and T-lymphoblastic lymphoma. We also evaluated PDL1 expression using tumor tissue of 76 patients. High PDL1 expression (positive staining of > 50% of tumor cells) was more frequent in NK/T-cell lymphoma and primary mediastinal B-cell lymphoma than other subtypes. Thus, PDL1 expression was significantly higher in EBV-positive (18/32, 56%) than EBV-negative NHL (4/38, 11%, p < 0.001). Furthermore, NK/T-cell lymphoma patients with high PDL1 expression showed a higher response (4/6, 67%) than those with low PDL1 expression (1/5, 20%).
Conclusion
Pembrolizumab could be useful as a salvage treatment for relapsed or refractory EBV-positive NHL, especially NK/T-cell lymphoma. However, its efficacy in EBV-negative NHL with low or absent PDL1 expression is still not clear although pembrolizumab could be a potential treatment option for relapsed or refractory NHL. -
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- Clinical Outcomes of EGFR Exon 20 Insertion Mutations in Advanced Non-small Cell Lung Cancer in Korea
- Seonggyu Byeon, Youjin Kim, Sung Won Lim, Jang Ho Cho, Sehoon Park, Jiyun Lee, Jong-Mu Sun, Yoon-La Choi, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn
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- DOI: https://doi.org/10.4143/crt.2018.151
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Epidermal growth factor receptor (EGFR) exon 20 insertion mutations account for approximately 4% of all EGFR mutations. Given the rarity of this mutation, its clinical outcomes are not fully established.
Materials and Methods
Between 2009 and 2017, non-small cell lung cancer (NSCLC) patients who showed an exon 20 insertion were retrospectively reviewed for clinical characteristics and outcomes, including responses to chemotherapy (CTx) or targeted therapy.
Results
Of 3,539 NSCLC patients who harbored an activating EGFR mutation, 56 (1.6%) had an exon 20 insertion. Of the advanced NSCLC patients, 27 of 1,479 (1.8%) had an exon 20 insertion. The median overall survival was 29.4 months (95% confidence interval 9.3 to 49.6) for 27 advancedNSCLC patients. The 22 patientswho received systemic CTx achieved a 50.0% response rate and a 77.2% disease control rate, with 4.2 months of progressionfree survival. Six patients received EGFR tyrosine kinase inhibitors (TKIs). Three of the four patients that had only an exon 20 insertion showed progressive disease, while one showed stable disease. The othertwo patients had an exon 20 insertion and another EGFR mutation and achieved a partial response.
Conclusion
The incidence of an exon 20 insertion mutation is rare in Korea and occasionally accompanied by other common EGFR mutations. Although the response to systemic CTx. in these patients is comparable to that of patients with other mutations, the response rate to firstor second-generation EGFR TKIs is quite low. Therefore, the development of a more efficient agent is urgently needed. -
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- Effect of Estradiol in an Azoxymethane/Dextran Sulfate Sodium-Treated Mouse Model of Colorectal Cancer: Implication for Sex Difference in Colorectal Cancer Development
- Hee Jin Son, Sung Hwa Sohn, Nayoung Kim, Ha-Na Lee, Sun Min Lee, Ryoung Hee Nam, Ji Hyun Park, Chin-Hee Song, Eun Shin, Hee Young Na, Joo Sung Kim, Dong Ho Lee, Young-Joon Surh
- Cancer Res Treat. 2019;51(2):632-648. Published online August 1, 2018
- DOI: https://doi.org/10.4143/crt.2018.060
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
This study demonstrates that estradiol downregulates inflammation and inhibits colorectal cancer (CRC) development in azoxymethane/dextran sulfate sodium (AOM/DSS) mouse model.
Materials and Methods
AOM/DSS-treated male and female mice were sacrificed at weeks 2, 10, and 16, to assess estrogen effects on colitis and carcinogenesis. Macroscopic and histologic severity of colitis and Western blot and quantitative real-time polymerase chain reaction were evaluated, to measure inflammatory mediators and cytokines.
Results
Compared with AOM/DSS-treated male mice (M-AOM/DSS group), AOM/DSS-treated male mice with estradiol administration (M-AOM/DSS+estr group) displayed at week 2 significantly decreased severity of colitis. At weeks 10 and 16, AOM/DSS-treated female mice (F-AOM/DSS group) and the M-AOM/DSS+estr group showed significantly lower tumor multiplicity compared with the M-AOM/DSS group. At week 2, F-AOM/DSS group had a lower level of nuclear factor-κB (NF-κB) expression and higher level of nuclear factor erythroid 2-related factor 2 (Nrf2) expression, compared to the M-AOM/DSS group. At week 2, expression levels of NF-κB and its related mediators decreased in the M-AOM/DSS+estr group, while levels of Nrf2 and Nrf2-related anti-oxidant enzymes increased. In addition, estradiol significantly increased Nod-like receptor protein 3 (NLRP3) inflammasome expressions in AOM/DSS-treated male mice. In contrast, at weeks 10 and 16, Nrf2 and its-related anti-oxidant enzymes and NLRP3 inflammasome were highly expressed in M-AOM/DSS group and in F-AOM/DSS group, who developed cancer.
Conclusion
The data suggest that estradiol inhibits the initiation of CRC by regulating Nrf2-related pathways. Moreover, these imply the dual role of Nrf2 and NLRP3 inflammasome, including promotion of tumor progression upon tumor initiation. -
Citations
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- Prognostic Role and Clinical Association of Tumor-Infiltrating Lymphocyte, Programmed Death Ligand-1 Expression with Neutrophil-Lymphocyte Ratio in Locally Advanced Triple-Negative Breast Cancer
- Jieun Lee, Dong-Min Kim, Ahwon Lee
- Cancer Res Treat. 2019;51(2):649-663. Published online July 31, 2018
- DOI: https://doi.org/10.4143/crt.2018.270
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Tumor-infiltrating lymphocyte (TIL), programmed death-ligand 1 (PD-L1) expression and neutrophil-to-lymphocyte ratio (NLR) is associated to immunogenicity and prognosis of breast cancer. We analyzed baseline NLR, changes of NLR, TIL, and PD-L1 during neoadjuvant chemotherapy (NAC) and their clinical implication in triple-negative breast cancer (TNBC).
Materials and Methods
Between January 2008 to December 2015, 358 TNBC patients were analyzed. Baseline NLR, 50 paired NLR (initial diagnosis, after completion of NAC) and 34 paired tissues (initial diagnosis, surgical specimen after completion of NAC) were collected. Changes of TIL, CD4, CD8, forkhead box P3 (FOXP3), and PD-L1 expression were assessed with immunohistochemical stain.
Results
Low NLR (≤ 3.16) was associated to superior survival (overall survival: 41.83 months vs. 36.5 months, p=0.002; disease-free survival [DFS]: 37.85 months vs. 32.14 months, p=0.032). Modest NLR change after NAC (–30% < NLR change < 100%) showed prolonged DFS (38.37 months vs. 22.37 months, p=0.015). During NAC, negative or negative conversion of tumor PD-L1 expression was associated to poor DFS (34.77 months vs. 16.03 months, p=0.037), and same or increased TIL showed trends for superior DFS, but without statistical significance. Positive tumor PD-L1 expression (H-score ≥ 5) in baseline or post- NAC tissue was associated to superior DFS (57.6 months vs. 12.5 months, p=0.001 and 53.3 months vs. 18.9 months, p=0.040). Positive stromal PD-L1 expression in baseline was also associated to superior DFS (50.2 months vs. 20.4 months, p=0.002).
Conclusion
In locally advanced TNBC, baseline NLR, changes of NLR during NAC was associated to survival. Baseline PD-L1 expression and changes of PD-L1 expression in tumor tissue during NAC also showed association to prognosis. -
Citations
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Parisa Lotfinejad, Mohammad Asghari Jafarabadi, Mahdi Abdoli Shadbad, Tohid Kazemi, Fariba Pashazadeh, Siamak Sandoghchian Shotorbani, Farhad Jadidi Niaragh, Amir Baghbanzadeh, Nafiseh Vahed, Nicola Silvestris, Behzad Baradaran
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- Neutrophil–lymphocyte ratio reflects tumour‐infiltrating lymphocytes and tumour‐associated macrophages and independently predicts poor outcome in breast cancers with neoadjuvant chemotherapy
- 11,433 View
- 571 Download
- 56 Web of Science
- 46 Crossref
- Albumin-to-Fibrinogen Ratio as an Independent Prognostic Parameter in Untreated Chronic Lymphocytic Leukemia: A Retrospective Study of 191 Cases
- Yi-Xin Zou, Jia Qiao, Hua-Yuan Zhu, Rui-Nan Lu, Yi Xia, Lei Cao, Wei Wu, Hui Jin, Wen-Jie Liu, Jin-Hua Liang, Jia-Zhu Wu, Li Wang, Lei Fan, Wei Xu, Jian-Yong Li
- Cancer Res Treat. 2019;51(2):664-671. Published online August 1, 2018
- DOI: https://doi.org/10.4143/crt.2018.358
-
Abstract
PDFPubReaderePub
- Purpose
Chronic lymphocytic leukemia (CLL) is one of the most frequent type of B-cell chronic lymphoproliferative disorders and chronic inflammation takes part in the development of CLL. However, there has been no valid immune biomarker to predict the prognosis of untreated CLL patients.
Materials and Methods
In this retrospective study, we analyzed the clinical correlations and prognostic value of albumin-to-fibrinogen ratio (AFR) detected at diagnosis in 191 CLL patients.
Results
The cut-off value of AFR was 9.7 calculated by X-tile. Patients who were more than 65 years old were often accompanied by low level of AFR (p < 0.001). Survival analysis showed that patients with low level of AFR had shorter overall survival (OS) than patients with high level of AFR (p < 0.001). Multivariate analysis illustrated that AFR had a negative impact on OS (p=0.003) and was independent of parameters involved in CLL international prognostic index and other prognostic markers such as CD38 and ZAP-70.
Conclusion
These data provide a comprehensive view of AFR and shows that AFR at diagnosis is an adverse prognostic factor in untreated CLL patients. -
Citations
Citations to this article as recorded by- Fibrinogen-albumin ratio predicts treatment response in phospholipase A2 receptor-associated membranous nephropathy with nephrotic syndrome
Suyan Duan, Si Chen, Chen Chen, Fang Lu, Ying Pan, Yifei Lu, Qing Li, Simeng Liu, Bo Zhang, Huijuan Mao, Changying Xing, Yanggang Yuan
Renal Failure.2024;[Epub] CrossRef - The diagnostic value of neutrophil to lymphocyte ratio, albumin to fibrinogen ratio, and lymphocyte to monocyte ratio in Parkinson’s disease: a retrospective study
Yi-Ming Li, Xiao-Hu Xu, Li-Na Ren, Xiao-Fan Xu, Yi-Long Dai, Rui-Rui Yang, Cheng-Qiang Jin
Frontiers in Neurology.2024;[Epub] CrossRef - Biomarkers for the diagnosis and treatment of rheumatoid arthritis – a systematic review
D Abdelhafiz, T Baker, DA Glascow, Ah Abdelhafiz
Postgraduate Medicine.2023; 135(3): 214. CrossRef - Development and validation of machine learning models for predicting prognosis and guiding individualized postoperative chemotherapy: A real-world study of distal cholangiocarcinoma
Di Wang, Bing Pan, Jin-Can Huang, Qing Chen, Song-Ping Cui, Ren Lang, Shao-Cheng Lyu
Frontiers in Oncology.2023;[Epub] CrossRef - Albumin-to-fibrinogen ratio is an independent prognostic parameter in de novo non-M3 acute myeloid leukemia
Yaqun Ding, Xiangyu Qi, Yang Li, Yanni Sun, Jia Wan, Chengxin Luo, Yarui Huang, Qingrong Li, Guixian Wu, Xiaoqing Zhu, Shuangnian Xu
Clinical and Experimental Medicine.2023; 23(8): 4597. CrossRef - The combination of preoperative fibrinogen-to-albumin ratio and postoperative TNM stage (FAR-TNM) predicts the survival in gastric cancer patients after gastrectomy
Xunlei Zhang, Xinyue Qiu, Haibing Yin, Wenjing Zhao, Li Song, Xingsong Zhang, Lei Yang, Min Tao
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Wenkai Xia, Meisi Kuang, Chenyu Li, Xiajuan Yao, Yan Chen, Jie Lin, Hong Hu
Frontiers in Medicine.2022;[Epub] CrossRef - Distinct Age-Related Clinical Features and Risk Assessment in Chinese With Chronic Lymphocytic Leukemia
Zheng Tian, Ming Liu, Xiaosheng Fang, Xiangxiang Zhou, Peipei Li, Ying Li, Lingyan Zhang, Fang Liu, Ya Zhang, Xin Wang
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Arina Onoprienko, Gerda Hofstetter, Tim Dorittke, Christine Bekos, Christoph Grimm, Mariella Polterauer, Thomas Bartl, Stephan Polterauer
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Lin Fang, Fei-Hu Yan, Chao Liu, Jing Chen, Dan Wang, Chun-Hui Zhang, Chang-Jie Lou, Jie Lian, Yang Yao, Bo-Jun Wang, Rui-Yang Li, Shu-Ling Han, Yi-Bing Bai, Jia-Ni Yang, Zhi-Wei Li, Yan-Qiao Zhang
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Zulipikaer Maimaiti, Chi Xu, Jun Fu, William Tianyu Li, Wei Chai, Yonggang Zhou, Jiying Chen
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Fan Cao, Xinxin Chen, Guodong Huang, Wenhua Liu, Na Zhou, Huili Yuan, Minghui Zou
Frontiers in Pediatrics.2021;[Epub] CrossRef - Is Serum C- Reactive Protein to Albumin Ratio Be A New Biomarker for Assessing Disease Activity and Quality of Life in Rheumatoid Arthritis?
Elif BALEVİ BATUR, Funda LEVENDOĞLU
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Yujue He, Jifeng Tang, Bodeng Wu, Bin Yang, Qishui Ou, Jinpiao Lin
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Da-wei Sun, Lin An, Guo-yue Lv
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Ziyan Zhang, Rui Zhang, Jiaqian Qi, Wenjing Miao, Kun Fang, Changgeng Ruan, Depei Wu, Yue Han
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Shao-Jun Xu, Guo-Sheng Lin, Hong-Jian Ling, Ren-Jie Guo, Jie Chen, Yi-Ming Liao, Tao Lin, Yong-Jian Zhou
Cancer Management and Research.2020; Volume 12: 11713. CrossRef- Preoperative albumin-to-fibrinogen ratio predicts chemotherapy resistance and prognosis in patients with advanced epithelial ovarian cancer
Wen Yu, Zhongxue Ye, Xi Fang, Xingzhi Jiang, Yafen Jiang
Journal of Ovarian Research.2019;[Epub] CrossRef
- Fibrinogen-albumin ratio predicts treatment response in phospholipase A2 receptor-associated membranous nephropathy with nephrotic syndrome
- 9,039 View
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- 20 Web of Science
- 18 Crossref
- Prediction of Acquired Taxane Resistance Using a Personalized Pathway-Based Machine Learning Method
- Young Rae Kim, Dongha Kim, Sung Young Kim
- Cancer Res Treat. 2019;51(2):672-684. Published online August 10, 2018
- DOI: https://doi.org/10.4143/crt.2018.137
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
This study was conducted to develop and validate an individualized prediction model for automated detection of acquired taxane resistance (ATR).
Materials and Methods
Penalized regression, combinedwith an individualized pathway score algorithm,was applied to construct a predictive model using publically available genomic cohorts of ATR and intrinsic taxane resistance (ITR). To develop a model with enhanced generalizability, we merged multiple ATR studies then updated the learning parameter via robust cross-study validation.
Results
For internal cross-study validation, the ATR model produced a perfect performance with an overall area under the receiver operating curve (AUROC) of 1.000 with an area under the precision-recall curve (AUPRC) of 1.000, a Brier score of 0.007, a sensitivity and a specificity of 100%. The model showed an excellent performance on two independent blind ATR cohorts (overall AUROC of 0.940, AUPRC of 0.940, a Brier score of 0.127). When we applied our algorithm to two large-scale pharmacogenomic resources for ITR, the Cancer Genome Project (CGP) and the Cancer Cell Line Encyclopedia (CCLE), an overall ITR cross-study AUROC was 0.70, which is a far better accuracy than an almost random level reported by previous studies. Furthermore, this model had a high transferability on blind ATR cohorts with an AUROC of 0.69, suggesting that general predictive features may be at work across both ITR and ATR.
Conclusion
We successfully constructed a multi-study–derived personalized prediction model for ATR with excellent accuracy, generalizability, and transferability. -
Citations
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Firat Ozcelik, Mehmet Sait Dundar, A. Baki Yildirim, Gary Henehan, Oscar Vicente, José A. Sánchez-Alcázar, Nuriye Gokce, Duygu T. Yildirim, Nurdeniz Nalbant Bingol, Dijana Plaseska Karanfilska, Matteo Bertelli, Lejla Pojskic, Mehmet Ercan, Miklos Kellerma
Functional & Integrative Genomics.2024;[Epub] CrossRef - Network biology and artificial intelligence drive the understanding of the multidrug resistance phenotype in cancer
Beatriz Bueschbell, Ana Beatriz Caniceiro, Pedro M.S. Suzano, Miguel Machuqueiro, Nícia Rosário-Ferreira, Irina S. Moreira
Drug Resistance Updates.2022; 60: 100811. CrossRef - Multiparametric quantitative phase imaging for real-time, single cell, drug screening in breast cancer
Edward R. Polanco, Tarek E. Moustafa, Andrew Butterfield, Sandra D. Scherer, Emilio Cortes-Sanchez, Tyler Bodily, Benjamin T. Spike, Bryan E. Welm, Philip S. Bernard, Thomas A. Zangle
Communications Biology.2022;[Epub] CrossRef - Machine Learning: An Overview and Applications in Pharmacogenetics
Giovanna Cilluffo, Salvatore Fasola, Giuliana Ferrante, Velia Malizia, Laura Montalbano, Stefania La Grutta
Genes.2021; 12(10): 1511. CrossRef - Computational approaches in cancer multidrug resistance research: Identification of potential biomarkers, drug targets and drug-target interactions
A. Tolios, J. De Las Rivas, E. Hovig, P. Trouillas, A. Scorilas, T. Mohr
Drug Resistance Updates.2020; 48: 100662. CrossRef - FLOating-Window Projective Separator (FloWPS): A Data Trimming Tool for Support Vector Machines (SVM) to Improve Robustness of the Classifier
Victor Tkachev, Maxim Sorokin, Artem Mescheryakov, Alexander Simonov, Andrew Garazha, Anton Buzdin, Ilya Muchnik, Nicolas Borisov
Frontiers in Genetics.2019;[Epub] CrossRef - New Paradigm of Machine Learning (ML) in Personalized Oncology: Data Trimming for Squeezing More Biomarkers From Clinical Datasets
Nicolas Borisov, Anton Buzdin
Frontiers in Oncology.2019;[Epub] CrossRef
- The impact and future of artificial intelligence in medical genetics and molecular medicine: an ongoing revolution
- 8,980 View
- 161 Download
- 6 Web of Science
- 7 Crossref
- Reduction of Target Volume and the Corresponding Dose for the Tumor Regression Field after Induction Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma
- Lei Wang, Zheng Wu, Dehuan Xie, Ruifang Zeng, Wanqin Cheng, Jiang Hu, Shaomin Huang, Shu Zhou, Rui Zhong, Yong Su
- Cancer Res Treat. 2019;51(2):685-695. Published online August 13, 2018
- DOI: https://doi.org/10.4143/crt.2018.250
-
Abstract
PDFPubReaderePub
- Purpose
This study aims to investigate the feasibility of contouring target volume according to residual tumor and decreasing the dose to the tumor regression field after induction chemotherapy (IC) in locoregionally advanced nasopharyngeal carcinoma (NPC).
Materials and Methods
From August 2009 to August 2013, patients with stage III–IVB NPC were treated with IC and concurrent chemoradiotherapy. Gross tumor volume of nasopharynx (GTVnx)–residual and gross tumor volume of cervical lymph node (GTVnd)–residual were contoured according to post-IC residual primary tumor and any N+ disease, respectively. The tumor regression field was included in CTVnx1/CTVnd1 and prescribed a dose of 60 Gy. Outcomes and toxicities of all patients were evaluated.
Results
A total of 57 patients were enrolled. At a median follow-up of 68 months, three cases displayed locoregional recurrence and one case showed both distant metastasis and locoregional recurrence. All locoregional recurrences were in the GTVnx-residual/GTVnd-residual and in-field. The 5-year overall, locoregional relapse-free, distant metastasis-free, and progression-free survival rates were 82.2%, 87.7%, 85.8% and 80.3%, respectively.
Conclusion
After IC, contouring of GTVnx-residual/GTVnd-residual as residual tumor volume and distribution 60 Gy ofradiation dose to the tumorregression field may be feasible and need further investigation. -
Citations
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Shu Zhang, Ni Zeng, Jiangping Yang, Jiaqi Han, Jinlan He, Baofeng Duan, Xiaoqiang Chen, Xiaofang Gou, Fubin Zhu, Huizhen Liu, Ming Zeng, Di Yan, Nianyong Chen
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Qian Chen, Liangfang Shen, Shan Li
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Zheng Wu, Bin Qi, Fei-Fei Lin, Lin Zhang, Qian He, Fei-Ping Li, Hui Wang, Ya-Qian Han, Wen-Jing Yin
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Fen Xue, Dan Ou, Xiaomin Ou, Xin Zhou, Chaosu Hu, Xiayun He
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Shan Li, Liangfang Shen
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Lachlan McDowell, June Corry, Jolie Ringash, Danny Rischin
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Shan Li, Liangfang Shen
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Cancer Communications.2019; 39(1): 1. CrossRef - Cisplatin/docetaxel/fluorouracil
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Youming Zhang, Xiaoping Yi, Jianming Gao, Li Li, Lizhi Liu, Ting Qiu, Jinlei Zhang, Yuanchao Zhang, Weihua Liao
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- Recurrent Patterns in Patients With Nasopharyngeal Caricinoma and Risks Leading to Inaccurate Delineation in Marginal Failure in the Era of Intensity‐Modulated Radiotherapy
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- 23 Web of Science
- 25 Crossref
- Disulfiram, a Re-positioned Aldehyde Dehydrogenase Inhibitor, Enhances Radiosensitivity of Human Glioblastoma Cells In Vitro
- Hyeon Kang Koh, Soo Yeon Seo, Jin Ho Kim, Hak Jae Kim, Eui Kyu Chie, Seung-Ki Kim, Il Han Kim
- Cancer Res Treat. 2019;51(2):696-705. Published online August 13, 2018
- DOI: https://doi.org/10.4143/crt.2018.249
-
Abstract
PDFPubReaderePub
- Purpose
Glioblastoma, the most common brain tumor in adults, has poor prognosis. The purpose of this study was to determine the effect of disulfiram (DSF), an aldehyde dehydrogenase inhibitor, on in vitro radiosensitivity of glioblastoma cells with different methylation status of O6-methylguanine-DNA methyltransferase (MGMT) promoter and the underlying mechanism of such effect.
Materials and Methods
Five human glioblastoma cells (U138MG, T98G, U251MG, U87MG, and U373MG) and one normal human astrocyte (NHA) cell were cultured and treated with DSF or 6MV X-rays (0, 2, 4, 6, and 8 Gy). For combined treatment, cells were treated with DSF before irradiation. Surviving fractions fit from cell survival based on colony forming ability. Apoptosis, DNA damage repair, and cell cycle distributionwere assayed bywestern blot for cleaved caspase-3, γH2AX staining, and flow cytometry, respectively.
Results
DSF induced radiosensitization in most of the glioblastoma cells, especially, in the cells with radioresistance as wildtype unmethylated promoter (MGMT-wt), but did not in normal NHA cell. DSF augmented or induced cleavage of caspase-3 in all cells after irradiation. DSF inhibited repair of radiation-induced DNA damage in MGMT-wt cells, but not in cells with methylated MGMT promoter. DSF abrogated radiation-induced G2/M arrest in T98G and U251MG cells.
Conclusion
Radiosensitivity of glioblastoma cells were preferentially enhanced by pre-irradiation DSF treatment compared to normal cell, especially radioresistant cells such as MGMT-wt cells. Induction of apoptosis or inhibition of DNA damage repair may underlie DSF-induced radiosensitization. Clinical benefit of combining DSF with radiotherapy should be investigated in the future. -
Citations
Citations to this article as recorded by- The role of KDM4A‐mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis
Xi‐Xi Li, Jia‐Kun Xu, Wei‐Jie Su, Hong‐Lin Wu, Kun Zhao, Chang‐Ming Zhang, Xiang‐Kun Chen, Li‐Xuan Yang
The Kaohsiung Journal of Medical Sciences.2024; 40(2): 161. CrossRef - Glioblastoma Therapy: Past, Present and Future
Elena Obrador, Paz Moreno-Murciano, María Oriol-Caballo, Rafael López-Blanch, Begoña Pineda, Julia Gutiérrez-Arroyo, Alba Loras, Luis Gonzalez-Bonet, Conrado Martinez-Cadenas, José Estrela, María Marqués-Torrejón
International Journal of Molecular Sciences.2024; 25(5): 2529. CrossRef - Exploring Disulfiram’s Anticancer Potential: PLGA Nano-Carriers for Prolonged Drug Delivery and Potential Improved Therapeutic Efficacy
Ibrahim Dumbuya, Ana Maria Pereira, Ibrahim Tolaymat, Adnan Al Dalaty, Basel Arafat, Matt Webster, Barbara Pierscionek, Mouhamad Khoder, Mohammad Najlah
Nanomaterials.2024; 14(13): 1133. CrossRef - Targeting Retinaldehyde Dehydrogenases to Enhance Temozolomide Therapy in Glioblastoma
Rafael Jiménez, Andrada Constantinescu, Muhube Yazir, Paula Alfonso-Triguero, Raquel Pequerul, Xavier Parés, Mileidys Pérez-Alea, Ana Paula Candiota, Jaume Farrés, Julia Lorenzo
International Journal of Molecular Sciences.2024; 25(21): 11512. CrossRef - Clinical, pharmacological, and formulation evaluation of disulfiram in the treatment of glioblastoma - a systematic literature review
Beáta-Mária Benkő, Dimitrios A. Lamprou, Anna Sebestyén, Romána Zelkó, István Sebe
Expert Opinion on Drug Delivery.2023; 20(4): 541. CrossRef - Effect of Disulfiram and Copper Plus Chemotherapy vs Chemotherapy Alone on Survival in Patients With Recurrent Glioblastoma
Katja Werlenius, Sara Kinhult, Tora Skeidsvoll Solheim, Henriette Magelssen, David Löfgren, Munila Mudaisi, Sofia Hylin, Jiri Bartek, Michael Strandéus, Magnus Lindskog, Havyan Bahroz Rashid, Louise Carstam, Sasha Gulati, Ole Solheim, Jiri Bartek, Øyvind
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Yao Liu, Xin Guan, Meiling Wang, Naixue Wang, Yutong Chen, Baolei Li, Zhuxuan Xu, Fangwei Fu, Cheng Du, Zhendong Zheng
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Hany E. Marei
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Renyan Tang, Jianmin Zhu, Ying Liu, Ning Wu, Jinbin Han
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Hyeon Ji Kim, Tae-Jun Kim, Yu Gyung Kim, Chaeeun Seong, Jin-Hwa Cho, Wanil Kim, Kyung-Ha Lee, Do-Yeon Kim
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Chan-Chuan Liu, Cheng-Lin Wu, Meng-Xuan Lin, Chun-I Sze, Po-Wu Gean
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Lisa Zirjacks, Nicolai Stransky, Lukas Klumpp, Lukas Prause, Franziska Eckert, Daniel Zips, Sabine Schleicher, Rupert Handgretinger, Stephan M. Huber, Katrin Ganser
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Francisco Meraz-Torres, Sarah Plöger, Claus Garbe, Heike Niessner, Tobias Sinnberg
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Elmira Ekinci, Sagar Rohondia, Raheel Khan, Qingping P. Dou
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- The role of KDM4A‐mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis
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- The Clinical Value of PELP1 for Breast Cancer: A Comparison with Multiple Cancers and Analysis in Breast Cancer Subtypes
- Xingen Wang, Julia Y. S. Tsang, Michelle A Lee, Yun-Bi Ni, Joanna H Tong, Siu-Ki Chan, Sai-Yin Cheung, Ka Fai To, Gary M Tse
- Cancer Res Treat. 2019;51(2):706-717. Published online August 23, 2018
- DOI: https://doi.org/10.4143/crt.2018.316
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Proline, glutamic acid, and leucine-rich protein 1 (PELP1), a novel nuclear receptor (NR) co-regulator, is highly expressed in breast cancer. We investigated its expression in breast cancer subtypes, in comparison with other breast markers as well as cancers from different sites. Its prognostic relevance with different subtypes and other NR expression was also examined in breast cancers.
Methods
Immunohistochemical analysis was performed on totally 1,944 cancers from six different organs.
Results
PELP1 expression rate was the highest in breast cancers (70.5%) among different cancers. Compared to GATA3, mammaglobin and gross cystic disease fluid protein 15, PELP1 was less sensitive than GATA3 for luminal cancers, but was the most sensitive for non-luminal cancers. PELP1 has low expression rate (<20%) in colorectal cancers, gastric cancers and renal cell carcinomas, but higher in lung cancers (49.1%) and ovarian cancers (42.3%). In breast cancer, PELP1 expression was an independent adverse prognostic factor for non-luminal cancers (disease-free survival [DFS]: hazard ratio [HR], 1.403; p=0.012 and breast cancer specific survival [BCSS]: HR, 1.443; p=0.015). Interestingly, its expression affected the prognostication of androgen receptor (AR). ARposPELP1lo luminal cancer showed the best DFS (log-rank=8.563, p=0.036) while ARnegPELP1hi non-luminal cancers showed the worst DFS (log-rank=9.536, p=0.023).
Conclusion
PELP1 is a sensitive marker for breast cancer, particularly non-luminal cases. However, its considerable expression in lung and ovarian cancers may limit its utility in differential diagnosis in some scenarios. PELP1 expression was associated with poor outcome in non-luminal cancers and modified the prognostic effects of AR, suggesting the potential significance of NR co-regulator in prognostication. -
Citations
Citations to this article as recorded by- Trichorhinophalangeal Syndrome Type 1 Is a Highly Sensitive and Specific Marker for Diagnosing Triple-Negative Breast Carcinomas on Cytologic Samples
Terrance J. Lynn, Jianhui Shi, Haiyan Liu, Sara E. Monaco, Jeffrey W. Prichard, Fan Lin
Archives of Pathology & Laboratory Medicine.2024; 148(1): e1. CrossRef - Value of Proline, Glutamic Acid, and Leucine-Rich Protein 1 and GATA Binding Protein 3 Expression in Breast Cancer: An Immunohistochemical study
Manar Moustafa, Magdy Ismael, Salah Mohamed, Abeer M. Hafez
Indian Journal of Surgery.2023; 85(3): 608. CrossRef - MiR-195-5p is involved in testicular ischemia/reperfusion injury by directly targeting PELP1 and regulating spermatogonia pyroptosis
KAI-XIANG HE, LIZHE XU, JIN-ZHUO NING, FAN CHENG
International Immunopharmacology.2023; 121: 110427. CrossRef - Estrogen Receptor Signaling in Breast Cancer
Paulina Miziak, Marzena Baran, Ewa Błaszczak, Alicja Przybyszewska-Podstawka, Joanna Kałafut, Jolanta Smok-Kalwat, Magdalena Dmoszyńska-Graniczka, Michał Kiełbus, Andrzej Stepulak
Cancers.2023; 15(19): 4689. CrossRef - Immunohistochemical study of proline, glutamic acid and leucine-rich protein 1 (PELP1) in correlation with guanine adenine thymine adenine family member 3 (GATA-3) receptors expression in breast carcinomas
Ahmed A Elmetwally, Mennat Allah M Abdel-Hafeez, Makram M Hammam, Gamal A Hafez, Maha M Atwa, Mohammed K El-Kherbetawy
Egyptian Journal of Pathology.2023; 43(1): 53. CrossRef - Diagnostic utility of PELP1 and GATA3 in primary and metastatic triple negative breast cancer
Manar Moustafa, Magdy Ismael, Salah Mohamed, Abeer Magdy
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Qingqing Ding, Lei Huo, Yan Peng, Esther C. Yoon, Zaibo Li, Aysegul A. Sahin
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Xingen Wang, Weihua Yin, Li Liang
Pathology - Research and Practice.2022; 237: 154065. CrossRef - Overexpression of PELP1 in Lung Adenocarcinoma Promoted E2 Induced Proliferation, Migration and Invasion of the Tumor Cells and Predicted a Worse Outcome of the Patients
Dongmei Zhang, Jiali Dai, Yu Pan, Xiuli Wang, Juanjuan Qiao, Hironobu Sasano, Baoshan Zhao, Keely M. McNamara, Xue Guan, Lili Liu, Yanzhi Zhang, Monica S. M. Chan, Shuwen Cao, Ming Liu, Sihang Song, Lin Wang
Pathology and Oncology Research.2021;[Epub] CrossRef - PELP1 Suppression Inhibits Gastric Cancer Through Downregulation of c-Src-PI3K-ERK Pathway
Hongzhu Yan, Yanling Sun, Qian Wu, Zhe Wu, Meichun Hu, Yuanpeng Sun, Yusi Liu, Zi Ma, Shangqin Liu, Wuhan Xiao, Fuxing Liu, Zhifeng Ning
Frontiers in Oncology.2020;[Epub] CrossRef
- Trichorhinophalangeal Syndrome Type 1 Is a Highly Sensitive and Specific Marker for Diagnosing Triple-Negative Breast Carcinomas on Cytologic Samples
- 7,687 View
- 165 Download
- 10 Web of Science
- 10 Crossref
- A Randomized, Open-Label, Phase II Study Comparing Pemetrexed Plus Cisplatin Followed by Maintenance Pemetrexed versus Pemetrexed Alone in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutant Non-small Cell Lung Cancer after Failure of First-Line EGFR Tyrosine Kinase Inhibitor: KCSG-LU12-13
- Kwai Han Yoo, Su Jin Lee, Jinhyun Cho, Ki Hyeong Lee, Keon Uk Park, Ki Hwan Kim, Eun Kyung Cho, Yoon Hee Choi, Hye Ryun Kim, Hoon-Gu Kim, Heui June Ahn, Ha Yeon Lee, Hwan Jung Yun, Jin-Hyoung Kang, Jaeheon Jeong, Moon Young Choi, Sin-Ho Jung, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn
- Cancer Res Treat. 2019;51(2):718-726. Published online September 3, 2018
- DOI: https://doi.org/10.4143/crt.2018.324
-
Abstract
PDFPubReaderePub
- Purpose
The optimal cytotoxic regimens have not been established for patients with non-small cell lung cancer (NSCLC) who develop disease progression on first-line epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI).
Materials and Methods
We conducted a multi-center randomized phase II trial to compare the clinical outcomes between pemetrexed plus cisplatin combination therapy followed by maintenance pemetrexed (PC) and pemetrexed monotherapy (P) after failure of first-line EGFR-TKI. The primary objective was progression-free survival (PFS), and secondary objectives included overall response rate (ORR), overall survival (OS), health-related quality of life (HRQOL), and safety and toxicity profiles.
Results
A total of 96 patientswere randomized, and 91 patientswere treated at 14 centers in Korea. The ORR was 34.8% (16/46) for the PC arm and 17.8% (8/45) for the P arm (p=0.066). With 23.4 months of follow-up, the median PFS was 5.4 months in the PC arm and 6.4 months in the P arm (p=0.114). The median OS was 17.9 months and 15.7 months in PC and P arms, respectively (p=0.787). Adverse events ≥ grade 3 were reported in 12 patients (26.1%) in the PC arm and nine patients (20.0%) in the P arm (p=0.491). The overall time trends of HRQOL were not significantly different between the two arms.
Conclusion
The outcomes of pemetrexed therapy in NSCLC patients with disease progression after firstline EGFR-TKI might not be improved by adding cisplatin. -
Citations
Citations to this article as recorded by-
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Wang Chun Kwok, Tan Fong Cheong, Ka Yan Chiang, James Chung Man Ho, David Chi Leung Lam, Mary Sau Man Ip, Terence Chi Chun Tam
Lung Cancer.2021; 152: 15. CrossRef - Exploring the role of epidermal growth factor receptor variant III in meningeal tumors
Rashmi Rana, Vaishnavi Rathi, Kirti Chauhan, Kriti Jain, Satnam Singh Chhabra, Rajesh Acharya, Samir Kumar Kalra, Anshul Gupta, Sunila Jain, Nirmal Kumar Ganguly, Dharmendra Kumar Yadav, Timir Tripathi
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Wang Chun Kwok, Ka Yan Chiang, James Chung Man Ho, David Chi Leung Lam, Mary Sau Man Ip, Terence Chi Chun Tam
Lung Cancer.2021; 162: 169. CrossRef - Impact of Value Frameworks on the Magnitude of Clinical Benefit: Evaluating a Decade of Randomized Trials for Systemic Therapy in Solid Malignancies
Ellen Cusano, Chelsea Wong, Eddy Taguedong, Marcus Vaska, Tasnima Abedin, Nancy Nixon, Safiya Karim, Patricia Tang, Daniel Y. C. Heng, Doreen Ezeife
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-
Osimertinib with Chemotherapy in
EGFR
-Mutated NSCLC
- 9,969 View
- 348 Download
- 11 Web of Science
- 11 Crossref
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