Skip Navigation
Skip to contents

Cancer Res Treat : Cancer Research and Treatment

OPEN ACCESS

Previous issues

Page Path
HOME > Browse articles > Previous issues
40 Previous issues
Filter
Filter
Article category
Keywords
Authors
Funded articles
Volume 50(4); October 2018
Prev issue Next issue
Original Articles
Health-Related Quality of Life in Non-Hodgkin Lymphoma Survivors: A Prospective Cohort Study
Danbee Kang, Juhee Cho, Im Ryung Kim, Mi Kyung Kim, Won Seog Kim, Seok Jin Kim
Cancer Res Treat. 2018;50(4):1051-1063.   Published online November 9, 2017
DOI: https://doi.org/10.4143/crt.2017.207
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
We evaluated health-related quality of life (HRQOL) in long-term survivors of indolent and aggressive non-Hodgkin lymphoma (NHL).
Materials and Methods
TheHRQOLwas assessed by the European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire Core 30 (EORTC QLQ-C30) at diagnosis in NHL patients between 2008 and 2011, and follow-up evaluation was conducted from June 2014 to February 2015 using EORTC QLQ-C30 and the quality of life in cancer survivors (QOL-CS) questionnaire. We used linear mixed models to compare changes in HRQOL between indolent and aggressive NHL over time.
Results
The HRQOL of long-term survivors with aggressive NHL improved to the similar level of indolent NHL during the follow-up survey. However, survivors of NHL were found to fear the probability of relapse and second malignancy, and the degree of fear was not different between survivors with aggressive stage I/II or III/IV NHL (p > 0.05). Furthermore, a half of survivors reported impaired sense of psychosocial well-being regardless of aggressiveness and stage during follow-up survey. More than 65% of survivors thought they did not receive sufficient support from others, and patients who had financial difficulties at diagnosis were more frequently associated with suffering from insufficient support. Impaired physical and cognitive functioning at diagnosis was significantly associated with lack of life purpose in long-term survivors.
Conclusion
The HRQOL of aggressive NHL survivors improved to a similar level to that of indolent NHL. However, the majority of survivors still had fear of relapse, and psychosocial well-being remained unmet needs.

Citations

Citations to this article as recorded by  
  • Attenuated adiponectin, omentin, increased interleukin-6 and tumor necrosis factor-alpha levels with altered cognition and depression in non-Hodgkin lymphoma patients: A case-control study
    Meghavi Kathpalia, Pinki Mishra, Afsha Majid, Mohd. Ashif Khan, Anurag Sharma, Dinesh Bhurani, Nidhi
    Journal of Neuroimmunology.2024; 392: 578372.     CrossRef
  • Quality of life and late therapy effects in pediatric non‐Hodgkin lymphoma survivors: Insights from a single‐institution study
    Azza Ayad, Reham Khedr, Asmaa Hamoda, Nahla Elnabarawy, Elhamy Rifky, Tamer Diab, Eman El Desouky, Leslie Lehmann, Alaa Elhaddad
    Pediatric Blood & Cancer.2024;[Epub]     CrossRef
  • Comparison of tisagenlecleucel with conventional treatments for relapsed/refractory diffuse large B-cell lymphomas: a retrospective external comparator study
    Sohee Park, Ju Hwan Kim, Songhee Kim, Jisu Kang, Seoyoung Moon, Seok Jin Kim, Ju-Young Shin
    Blood Cancer Journal.2023;[Epub]     CrossRef
  • Factors associated with long-term functional and psychosocial outcomes in patients with non-Hodgkin lymphoma
    Bhasker Amatya, Michael Dickinson , Fary Khan
    Journal of Rehabilitation Medicine.2023; 55: jrm004816.     CrossRef
  • Experiences of and preferences for self-management among low grade non-Hodgkin's lymphoma survivors: A qualitative interview study
    Nickola D. Pallin, Mairead O'Connor, Alannah Gannon, John Browne, Mary R. Cahill, Derville O'Shea
    European Journal of Oncology Nursing.2023; 66: 102378.     CrossRef
  • Factors Affecting Health-Related Quality of Life among Survivors of Non-Hodgkin Lymphoma: A Population-Based Study
    Stephane Kroudia Wasse, Morgane Mounier, Emerline Assogba, Cédric Rossi, Johan Adnet, Sophie Gauthier, Stephanie Girard, Kueshivi Midodji Atsou, Tienhan Sandrine Dabakuyo-Yonli, Marc Maynadie
    Cancers.2023; 15(15): 3885.     CrossRef
  • Lisocabtagene maraleucel for second-line relapsed or refractory large B-cell lymphoma: patient-reported outcomes from the PILOT study
    Leo I. Gordon, Fei Fei Liu, Julia Braverman, Daanish Hoda, Nilanjan Ghosh, Mehdi Hamadani, Gerhard C. Hildebrandt, Lily Peng, Shien Guo, Ling Shi, Alison Sehgal
    Haematologica.2023; 109(3): 857.     CrossRef
  • Quality of life and fear of cancer recurrence in patients and survivors of non-Hodgkin lymphoma
    Susan Ellis, Rhonda F. Brown, Einar B. Thorsteinsson, Kenneth I. Pakenham, Colin Perrott
    Psychology, Health & Medicine.2022; 27(8): 1649.     CrossRef
  • Pre‐treatment health‐related quality of life parameters have prognostic impact in patients >65 years with newly diagnosed mantle cell lymphoma: The Nordic Lymphoma Group MCL4 (LENA‐BERIT) experience
    Åsa Lindberg, Christian Winther Eskelund, Alexandra Albertsson‐Lindblad, Arne Kolstad, Anna Laurell, Riikka Räty, Kirsten Grønbæk, Christian Hartmann Geisler, Mats Jerkeman
    Hematological Oncology.2022; 40(1): 23.     CrossRef
  • Treatment Outcomes and Its Associated Factors Among Adult Patients with Selected Solid Malignancies at Kenyatta National Hospital: A Hospital-Based Prospective Cohort Study
    Amsalu Degu, Ermias Mergia Terefe, Eliab Seroney Some, Gobezie T Tegegne
    Cancer Management and Research.2022; Volume 14: 1525.     CrossRef
  • Living with or beyond lymphoma: A rapid review of the unmet needs of lymphoma survivors
    Vanessa Boland, Amanda Drury, Greg Sheaf, Anne‐Marie Brady
    Psycho-Oncology.2022; 31(7): 1076.     CrossRef
  • The forgotten survivor: A comprehensive review on Non‐Hodgkin lymphoma survivorship
    Mohamad S. Alabdaljabar, Urshila Durani, Carrie A. Thompson, Louis S. Constine, Shahrukh K. Hashmi
    American Journal of Hematology.2022; 97(12): 1627.     CrossRef
  • Unmet Needs and Quality of Life of Colorectal Cancer Survivors Immediately after Treatment Ends and 5 Years
    Hyedan Kim, Eunsook Wi, Mi Hwa Jang, Sung Hee Jo, Hye Kyung Kim
    Asian Oncology Nursing.2022; 22(3): 145.     CrossRef
  • Trajectories of symptom severity predicts quality of life change in newly diagnosis lymphoma survivors: An initial study
    Chih‐Jung Wu, Yu‐Chi Chen, Li‐Yuan Bai, Tzeon‐Jye Chiou, Kuan‐Chia Lin, Ya‐Jung Wang
    European Journal of Cancer Care.2022;[Epub]     CrossRef
  • Exploring health-related quality of life among non-Hodgkin’s lymphoma survivors after completion of primary treatment: a cross-sectional study in Thailand
    Pichitra Lekdamrongkul, Kanaungnit Pongthavornkamol, Alex Molassiotis, Aurawamon Sriyuktasuth, Noppadol Siritanaratkul, Natkamol Chansatitporn
    Supportive Care in Cancer.2021; 29(11): 6511.     CrossRef
  • Experiences of patients with lung cancer receiving concurrent chemo-radiotherapy
    Choi Eunsook, Park Sunhee
    Clinical Journal of Nursing Care and Practice.2021; 5(1): 015.     CrossRef
  • Coping strategies among patients with malignant lymphoma– a qualitative study from the perspectives of Swedish patients
    Stinne Glasdam, Charlotta Bjerström, Cecilia Engberg de Carvalho
    European Journal of Oncology Nursing.2020; 44: 101693.     CrossRef
  • Impact of fear of cancer recurrence on survival among lymphoma patients
    Seok Jin Kim, Danbee Kang, Im Ryung Kim, Sang Eun Yoon, Won Seog Kim, Phyllis N. Butow, Eliseo Guallar, Juhee Cho
    Psycho-Oncology.2020; 29(2): 364.     CrossRef
  • Health-related quality of life in the phase III GALLIUM study of obinutuzumab- or rituximab-based chemotherapy in patients with previously untreated advanced follicular lymphoma
    Andrew Davies, Peter Trask, Judit Demeter, Axel Florschütz, Mathias Hänel, Tomohiro Kinoshita, Ruth Pettengell, Hang Quach, Stephen Robinson, Shalal Sadullah, Juan-Manuel Sancho, Miklos Udvardy, Mathias Witzens-Harig, Andrea Knapp, Wenxin Liu
    Annals of Hematology.2020; 99(12): 2837.     CrossRef
  • Quality of Life and Impact of Cancer: Differences in Rural and Nonrural Non‐Hodgkin's Lymphoma Survivors
    Devon Noonan, Matthew LeBlanc, Cherie Conley, Habtamu Benecha, Ashley Leak‐Bryant, Kellen Peter, Sheryl Zimmerman, Deborah Mayer, Sophia Smith
    The Journal of Rural Health.2020; 36(4): 536.     CrossRef
  • Semen quality in non-Hodgkin lymphoma survivors: a monocentric retrospective study
    Francesco Pallotti, Marianna Pelloni, Fabiana Faja, Silvia Di Chiano, Alice Di Rocco, Andrea Lenzi, Francesco Lombardo, Donatella Paoli
    Human Reproduction.2020;[Epub]     CrossRef
  • Prognostic Value of Post-diagnosis Health-Related Quality of Life for Overall Survival in Breast Cancer: Findings from a 10-Year Prospective Cohort in Korea
    Tran Thi Xuan Mai, Jin Hyuk Choi, Myung Kyung Lee, Yoon Jung Chang, So-Youn Jung, Hyunsoon Cho, Eun Sook Lee
    Cancer Research and Treatment.2019; 51(4): 1600.     CrossRef
  • 16,915 View
  • 425 Download
  • 21 Web of Science
  • 22 Crossref
Close layer
The Prognostic Significance of Notch1 and Fatty Acid Binding Protein 7 (FABP7) Expression in Resected Tracheobronchial Adenoid Cystic Carcinoma: A Multicenter Retrospective Study
Mian Xie, Xiaojun Wu, Jinjun Zhang, Chaosheng He, Shenhai Wei, Junyao Huang, Xinge Fu, Yingying Gu
Cancer Res Treat. 2018;50(4):1064-1073.   Published online November 15, 2017
DOI: https://doi.org/10.4143/crt.2017.337
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Adenoid cystic carcinoma (ACC) of the trachea and bronchus is a rare tumor. Although MYB-NFIB oncogene fusion and Notch1 mutation have been identified in ACC, little is known about the expression and clinical significance of Notch1 and its target gene fatty acid binding protein 7 (FABP7) in tracheobronchial ACC.
Materials and Methods
Primary tracheobronchial ACC that were resected between 1998 and 2014 were identified through the pathology and oncology database from five thoracic oncology centers in China. A tissue array was constructed from the patients’ samples and the expressions of Notch1 and FABP7 were evaluated by immunohistochemistry. The association between the expression of both markers and survival was determined.
Results
Overexpression of Notch1 and FABP7, detected in 37.8% and 38.3% of 368 patients with tracheobronchial ACC, respectively, was an independent prognostic indicator for recurrencefree survival (RFS) by multivariable Cox proportional hazard model (p=0.032 and p=0.048, respectively). Overexpression of Notch1, but not of FABP7, predicted overall survival (OS) (p=0.018). When categorized into four groups according to coexpression of Notch1 and FABP7, patients with overexpression of both Notch1 and FABP7 belonged to the group with the shortest RFS and OS (p=0.01 and p=0.048, respectively).
Conclusion
Expression of Notch1 and FABP7, and coexpression of Notch1 and FABP7, is strongly associated with poor survival in resected tracheobronchial ACC. These data are consistent with the hypothesis that poor differentiation of tracheobronchial ACC correlates with the activation of Notch signaling.

Citations

Citations to this article as recorded by  
  • The emerging role of fatty acid binding protein 7 (FABP7) in cancers
    William George Warren, Myles Osborn, Andrew Yates, Saoirse E. O’Sullivan
    Drug Discovery Today.2024; 29(5): 103980.     CrossRef
  • Pulmonary adenoid cystic carcinoma: molecular characteristics and literature review
    Zhixin Chen, Jiapeng Jiang, Ying Fan, Hongyang Lu
    Diagnostic Pathology.2023;[Epub]     CrossRef
  • Identification of FABP7 as a Potential Biomarker for Predicting Prognosis and Antiangiogenic Drug Efficacy of Glioma
    Liubing Hou, Huandi Zhou, Yanqiang Wang, Junling Liu, Dongdong Zhang, Yuehong Li, Xiaoying Xue, Zhijie Xu
    Disease Markers.2022; 2022: 1.     CrossRef
  • Clinical Utility of Fine-Needle Aspiration Cytology for Adenoid Cystic Carcinoma of the Trachea with Thyroid Invasion: A Case Report
    Tomoo Jikuzono, Shigekazu Suzuki, Osamu Ishibashi, Shoko Kure, Atsuko Sakanushi, Munenaga Nakamizo, Masashi Kawamoto, Ryuji Ohashi, Tetsu Yamada, Iwao Sugitani
    Journal of Nippon Medical School.2022; 89(4): 460.     CrossRef
  • Identification of recurrent variants implicated in disease in bicuspid aortic valve patients through whole-exome sequencing
    Shasha Chen, Qinchun Jin, Shiqiang Hou, Mingfei Li, Yuan Zhang, Lihua Guan, Wenzhi Pan, Junbo Ge, Daxin Zhou
    Human Genomics.2022;[Epub]     CrossRef
  • A Case of Solid Variant of Adenoid Cystic Carcinoma from Trachea: A Case Report and Review of Literature
    Feng Gao, Lijuan Zang, Jin He, Weiqing Xu
    OncoTargets and Therapy.2021; Volume 14: 1997.     CrossRef
  • Role of FABP7 in tumor cell signaling
    Yoshiteru Kagawa, Banlanjo A. Umaru, Islam Ariful, Subrata Kumar Shil, Hirofumi Miyazaki, Yui Yamamoto, Masaki Ogata, Yuji Owada
    Advances in Biological Regulation.2019; 71: 206.     CrossRef
  • Role of fatty acid binding proteins (FABPs) in cancer development and progression
    Iain H. McKillop, Cara A. Girardi, Kyle J. Thompson
    Cellular Signalling.2019; 62: 109336.     CrossRef
  • Clinically Integrated Molecular Diagnostics in Adenoid Cystic Carcinoma
    Julia Thierauf, Nisha Ramamurthy, Vickie Y. Jo, Hayley Robinson, Ryan P. Frazier, Jonathan Gonzalez, Maciej Pacula, Enrique Dominguez Meneses, Vania Nose, Valentina Nardi, Dora Dias-Santagata, Long P. Le, Derrick T. Lin, William C. Faquin, Lori J. Wirth,
    The Oncologist.2019; 24(10): 1356.     CrossRef
  • FABP7 promotes cell proliferation and survival in colon cancer through MEK/ERK signaling pathway
    Ran Ma, Lan Wang, Fang Yuan, Shaoxuan Wang, Yingping Liu, Tingting Fan, Fulai Wang
    Biomedicine & Pharmacotherapy.2018; 108: 119.     CrossRef
  • 9,201 View
  • 233 Download
  • 8 Web of Science
  • 10 Crossref
Close layer
Supporting Low-income Cancer Patients: Recommendations for the Public Financial Aid Program in the Republic of Korea
Hye Sook Min, Hyung Kook Yang, Keeho Park
Cancer Res Treat. 2018;50(4):1074-1083.   Published online November 15, 2017
DOI: https://doi.org/10.4143/crt.2017.401
AbstractAbstract PDFPubReaderePub
Purpose
As the recent term of “financial toxicity” implies, cancer causes a treatment-related financial harm. Financial Aid Program for Cancer Patient (FAPCP) is a government’s financial support for low-income patients in the Republic of Korea. This study aimed to describe FAPCP applicants’ condition and to investigate factors influencing financial burden, which would provide the basis for implementing a strategy for FAPCP administration.
Materials and Methods
The telephone survey results from 2,700 FAPCP participants were analyzed, including demographic, socioeconomic, and disease characteristics and experiences associated with financial burden and the actions or measures to cope with them.
Results
Overall, 87.6% experienced financial burden more than moderate degree, 39.2% got financial help/a loan, 17.8% disposed of their property, and 10.2% changed or stopped treatment owing to medical costs. Monthly household income was connected to financial burden, and the highest income group was associated with the lowest financial burden (odds ratio [OR], 0.21; 95% confidence interval [CI], 0.11 to 0.38) and the lowest rate of changing/stopping care (OR, 0.23; 95% CI, 0.05 to 1.00). Parents of childhood cancer patients got financial help/a loan (OR, 2.24; 95% CI, 1.03 to 4.88) and disposed of their property (OR, 3.18; 95% CI, 1.40 to 7.22) more frequently, and Medical Aids applicants showed the highest rate of changing/stopping care (OR, 3.01; 95% CI, 1.89 to 4.78).
Conclusion
FAPCP targets low income groups; however, financial burden and the consequent actions taken still exist disproportionately, depending on the income of the applicants. FAPCP should focus on more vulnerable groups including Medical Aid applicants and parents of childhood cancer patients, by increasing funds and expanding their support coverage.

Citations

Citations to this article as recorded by  
  • Identifying the factors affecting financial toxicity status in patients with middle and advanced colorectal cancer: a cross-sectional study
    Xiaofang He, Jie Chen, Lin Zhang, Qiuping Li, Xiaoli Zhu, Jie Zhao, Ying Chen
    Frontiers in Public Health.2024;[Epub]     CrossRef
  • Individual and joint effect of socioeconomic status and lifestyle factors on cancer in Korea
    Chi Lan Tran, Kui Son Choi, Sun‐Young Kim, Jin‐Kyoung Oh
    Cancer Medicine.2023; 12(16): 17389.     CrossRef
  • Financial hardship in families of children or adolescents with cancer: a systematic literature review
    Julie Ritter, Savannah Allen, Phillip D Cohen, Andrés Felipe Fajardo, Kelsey Marx, Patrícia Loggetto, Carmen Auste, Hedley Lewis, Karla Emília de Sá Rodrigues, Sharmeen Hussain, Ayomide Omotola, Nancy S Bolous, Harsha Thirumurthy, Beverley M Essue, Eva St
    The Lancet Oncology.2023; 24(9): e364.     CrossRef
  • Trends in medical care utilization in patients with cancer: An analysis of real‐world data in a tertiary hospital in Korea, 2014–2019
    Jung‐Hyun Won, Tae Kyu Chung, Joochul Lee, Sangwon Yoon, Yoomin Jeon, Howard Lee
    Cancer Medicine.2023; 12(22): 21022.     CrossRef
  • Impact of objective financial burden and subjective financial distress on spiritual well-being and quality of life among working-age cancer survivors
    Danbee Kang, Ka Ryeong Bae, Jihyun Lim, Nayeon Kim, Sungkeun Shim, Sun Seog Kweon, Hwa Jeong Seo, Juhee Cho
    Supportive Care in Cancer.2022; 30(6): 4917.     CrossRef
  • The influence of cross-regional medical treatment on total medical expenses, medical insurance payments, and out-of-pocket expenses of patients with malignant tumors in Chinese low-income areas
    Bokai Zhang, Haixin Wang, Hongyu Zhang, Guomei Tian, Ting Zhang, Qi Shi, Jian Liu, Jinpeng Xu, Jingchu Liu, Qunhong Wu, Zheng Kang
    Cost Effectiveness and Resource Allocation.2022;[Epub]     CrossRef
  • Financial Toxicity of Cancer Care: An Analysis of Financial Burden in Three Distinct Health Care Systems
    Divya A. Parikh, Meera Ragavan, Ritika Dutta, Jeffrey Garnet Edwards, James Dickerson, Debeshi Maitra, Sangeeta Aggarwal, Fa-Chyi Lee, Manali I. Patel
    JCO Oncology Practice.2021; 17(10): e1450.     CrossRef
  • Burden of Treatment among Elderly Patients with Cancer: A Scoping Review
    Adem Sav, Sara S. McMillan, Adeola Akosile
    Healthcare.2021; 9(5): 612.     CrossRef
  • Symptom experiences and health‐related quality of life among non‐small cell lung cancer patients participating in clinical trials
    Kyunghwa Lee, Eui Geum Oh, Sanghee Kim, Sang‐We Kim
    Journal of Clinical Nursing.2019; 28(11-12): 2111.     CrossRef
  • The Incidences and Characteristics of Various Cancers in Patients on Dialysis: a Korean Nationwide Study
    Soon Kil Kwon, Joung-Ho Han, Hye-Young Kim, Gilwon Kang, Minseok Kang, Yeonkook J. Kim, Jinsoo Min
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Higher Age Puts Lung Cancer Patients at Risk for Not Receiving Anti-cancer Treatment
    Won-Il Choi, Jiah Choi, Mi-Ae Kim, Gyumin Lee, Jihyeon Jeong, Choong Won Lee
    Cancer Research and Treatment.2019; 51(3): 1241.     CrossRef
  • 7,368 View
  • 130 Download
  • 11 Web of Science
  • 11 Crossref
Close layer
Proposal of a Pretreatment Nomogram for Predicting Local Recurrence after Intensity-Modulated Radiation Therapy in T4 Nasopharyngeal Carcinoma: A Retrospective Review of 415 Chinese Patients
Lu-Lu Zhang, Yi-Yang Li, Jiang Hu, Guan-Qun Zhou, Lei Chen, Wen-Fei Li, Ai-Hua Lin, Jun Ma, Zhen-Yu Qi, Ying Sun
Cancer Res Treat. 2018;50(4):1084-1095.   Published online November 15, 2017
DOI: https://doi.org/10.4143/crt.2017.359
AbstractAbstract PDFPubReaderePub
Purpose
Local relapse-free survival (LRFS) differs widely among patients with T4 category nasopharyngeal carcinoma (NPC). We aimed to build a nomogram incorporating clinicopathological information to predict LRFS in T4 NPC after definitive intensity-modulated radiation therapy (IMRT).
Materials and Methods
Retrospective study of 415 Chinese patients with non-metastatic T4 NPC treated with definitive IMRT with or without chemotherapy at our cancer center between October 2009 and September 2013. The nomogram for LRFS at 3 and 5 years was generated based on multivariate Cox proportional hazards regression, and validated using bootstrap resampling, assessing discriminative performance using the concordance index (C-index) and determining calibration ability via calibration curves.
Results
Five-year LRFS was 88.8%. We identified and incorporated four independent prognostic factors for LRFS: ethmoid sinus invasion, primary gross tumor volume, age, and pretreatment body mass index. The C-index of the nomogram for local recurrence was 0.732 (95% confidence interval, 0.726 to 0.738), indicating excellent predictive accuracy. The calibration curve revealed excellent agreement between nomogram-predicted and observed LRFS probabilities. Risk subgroups based on total point score cutoff values enabled effective discrimination of LRFS.
Conclusion
This pretreatment nomogram enables clinicians to accurately predict LRFS in T4 NPC after definitive IMRT, and could help to facilitate personalized patient counselling and treatment strategies.

Citations

Citations to this article as recorded by  
  • Radiomics and Deep Learning in Nasopharyngeal Carcinoma: A Review
    Zipei Wang, Mengjie Fang, Jie Zhang, Linquan Tang, Lianzhen Zhong, Hailin Li, Runnan Cao, Xun Zhao, Shengyuan Liu, Ruofan Zhang, Xuebin Xie, Haiqiang Mai, Sufang Qiu, Jie Tian, Di Dong
    IEEE Reviews in Biomedical Engineering.2024; 17: 118.     CrossRef
  • Novel prediction model combining PET/CT metabolic parameters, inflammation markers, and TNM stage: prospects for personalizing prognosis in nasopharyngeal carcinoma
    Huan Liang, Weilin Tan, Jie Wang, Mengdan Li, Hua Pang, Xiaohui Wang, Lu Yang, Xingguo Jing
    Annals of Nuclear Medicine.2024; 38(10): 802.     CrossRef
  • Can Epstein–Barr virus‐deoxyribonucleic acid load after induction chemotherapy combined with American Joint Committee on Cancer stage determine the chemotherapy intensity of locally advanced nasopharyngeal carcinoma?
    Qun Zhang, Zhen‐Wei Peng, Zhuo‐Sheng Gu, Yan Wang, Fang He, Wen‐Bin Zhao, Wei Luo, Yong‐Yu Mei
    Cancer Medicine.2023; 12(1): 223.     CrossRef
  • Prioritizing sufficient dose to gross tumor volume over normal tissue sparing in intensity‐modulated radiotherapy treatment of T4 nasopharyngeal carcinoma
    Yanyan Chen, Quxia Zhang, Tianzhu Lu, Cairong Hu, Jingfeng Zong, Yun Xu, Wei Zheng, Lisha Chen, Senan Lin, Sufang Qiu, Luying Xu, Jianji Pan, Qiaojuan Guo, Shaojun Lin
    Head & Neck.2023; 45(5): 1130.     CrossRef
  • Multi-task deep learning-based radiomic nomogram for prognostic prediction in locoregionally advanced nasopharyngeal carcinoma
    Bingxin Gu, Mingyuan Meng, Mingzhen Xu, David Dagan Feng, Lei Bi, Jinman Kim, Shaoli Song
    European Journal of Nuclear Medicine and Molecular Imaging.2023; 50(13): 3996.     CrossRef
  • Prognostic significance of AKR1C4 and the advantage of combining EBV DNA to stratify patients at high risk of locoregional recurrence of nasopharyngeal carcinoma
    Shan-Shan Guo, Yan-Zhou Chen, Li-Ting Liu, Rong-Ping Liu, Yu-Jing Liang, Dong-Xiang Wen, Jing Jin, Lin-Quan Tang, Hai-Qiang Mai, Qiu-Yan Chen
    BMC Cancer.2022;[Epub]     CrossRef
  • DeepMTS: Deep Multi-Task Learning for Survival Prediction in Patients With Advanced Nasopharyngeal Carcinoma Using Pretreatment PET/CT
    Mingyuan Meng, Bingxin Gu, Lei Bi, Shaoli Song, David Dagan Feng, Jinman Kim
    IEEE Journal of Biomedical and Health Informatics.2022; 26(9): 4497.     CrossRef
  • Development and Validation of Prognostic Nomograms Based on Gross Tumor Volume and Cervical Nodal Volume for Nasopharyngeal Carcinoma Patients With Concurrent Chemoradiotherapy
    Cui-Dai Zhang, Mei Li, Ying-Ji Hong, Ze-Man Cai, Kai-Chun Huang, Zhi-Xiong Lin, Zhi-Ning Yang
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Development and Validation of Web-Based Nomograms to Precisely Predict Survival Outcomes of Non-metastatic Nasopharyngeal Carcinoma in an Endemic Area
    Ji-Jin Yao, Li Lin, Tian-Sheng Gao, Wang-Jian Zhang, Wayne R. Lawrence, Jun Ma, Ying Sun
    Cancer Research and Treatment.2021; 53(3): 657.     CrossRef
  • Nomogram predict relapse-free survival of patients with thymic epithelial tumors after surgery
    Yang-Yu Huang, Lei-Lei Wu, Xuan Liu, Shen-Hua Liang, Guo-Wei Ma
    BMC Cancer.2021;[Epub]     CrossRef
  • Establishment and validation of a nomogram with intratumoral heterogeneity derived from 18F-FDG PET/CT for predicting individual conditional risk of 5-year recurrence before initial treatment of nasopharyngeal carcinoma
    Bingxin Gu, Jianping Zhang, Guang Ma, Shaoli Song, Liqun Shi, Yingjian Zhang, Zhongyi Yang
    BMC Cancer.2020;[Epub]     CrossRef
  • Prognostic Nomogram for Patients with Radical Surgery for Non-Metastatic Colorectal Cancer Incorporating Hematological Biomarkers and Clinical Characteristics


    Peiyun Long, Youya Zang, Huan Wang, Xiumei Liang, Xuekun Xie, Zhiwei Han, Dongyi Lin, Zongyu Wang, Shan Huang, Chuang Chen
    OncoTargets and Therapy.2020; Volume 13: 2093.     CrossRef
  • Impact of Paranasal Sinus Invasion on Oncologic and Dosimetric Outcomes in Nasopharyngeal Carcinoma Following Intensity-Modulated Radiation Therapy—Implications for Risk Stratification and Planning Optimization
    Xin Zhou, Xiayun He, Fen Xue, Xiaomin Ou, Chaosu Hu
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Role of IMRT/VMAT-Based Dose and Volume Parameters in Predicting 5-Year Local Control and Survival in Nasopharyngeal Cancer Patients
    Nicola Alessandro Iacovelli, Alessandro Cicchetti, Anna Cavallo, Salvatore Alfieri, Laura Locati, Eliana Ivaldi, Rossana Ingargiola, Domenico A. Romanello, Paolo Bossi, Stefano Cavalieri, Chiara Tenconi, Silvia Meroni, Giuseppina Calareso, Marco Guzzo, Ce
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Development of a Nomogram Model for Treatment of Nonmetastatic Nasopharyngeal Carcinoma
    Lu-Lu Zhang, Fei Xu, Di Song, Meng-Yao Huang, Yong-Shi Huang, Qi-Ling Deng, Yi-Yang Li, Jian-Yong Shao
    JAMA Network Open.2020; 3(12): e2029882.     CrossRef
  • Radiomics on multi-modalities MR sequences can subtype patients with non-metastatic nasopharyngeal carcinoma (NPC) into distinct survival subgroups
    En-Hong Zhuo, Wei-Jing Zhang, Hao-Jiang Li, Guo-Yi Zhang, Bing-Zhong Jing, Jian Zhou, Chun-Yan Cui, Ming-Yuan Chen, Ying Sun, Li-Zhi Liu, Hong-Min Cai
    European Radiology.2019; 29(10): 5590.     CrossRef
  • Impact of paranasal sinus invasion on advanced nasopharyngeal carcinoma treated with intensity‐modulated radiation therapy: the validity of advanced T stage of AJCC/UICC eighth edition staging system
    Ying Wang, Jie Zhao, Yajie Zhao, Zhen Yang, Mingjun Lei, Zhanzhan Li, Rui Wei, Dengming Chen, Yuxiang He, Liangfang Shen
    Cancer Medicine.2018; 7(7): 2826.     CrossRef
  • 8,617 View
  • 200 Download
  • 18 Web of Science
  • 17 Crossref
Close layer
Beliefs and Intentions to Undergo Lung Cancer Screening among Korean Males
Nhung Cam Bui, Yoon Young Lee, Mina Suh, Boyoung Park, Hyunsoon Cho, Yeol Kim, Kui Son Choi
Cancer Res Treat. 2018;50(4):1096-1105.   Published online November 16, 2017
DOI: https://doi.org/10.4143/crt.2017.393
AbstractAbstract PDFPubReaderePub
Purpose
Low-dose computed tomography (LDCT) has been reported as an effective screening method for lung cancer in high-risk populations. We aimed to examine willingness to be screened among Korean males using LDCT and to determine factors associated with lung cancer screening intentions (LCS) based on the Health Belief Model (HBM).
Materials and Methods
Data were obtained from the 2015 Korean National Cancer Screening Survey, a cross-sectional survey that utilized nationally representative random sampling. The survey included 1,730 male participants 40-74-year-old. Respondents were questioned regarding their willingness to undergo LCS and components of HBM. Factors associated with intentions to undergo screening were explored using logistic regression.
Results
Among participants, 65.2% were current smokers. Among high-risk subjects, 60.6% of men reported intentions to undergo LCS, compared to 49.9% of average-risk males. Men with higher perceived susceptibility in the average- and high-risk groups were, respectively, 1.63 (95% confidence interval [CI], 1.39 to 1.91) and 2.30 (95% CI, 1.14 to 4.63) times more likely to intend to undergo LCS compared to those with lower perceived barriers. Also, men in the average- and high-risk groups with higher perceived barriers to screening were, respectively, 0.79 (95% CI, 0.68 to 0.91) and 0.52 (95% CI, 0.29 to 0.92) times less likely to intend to undergo LCS compared to those with lower perceived barriers.
Conclusion
Tailored interventions designed to promote accurate perceptions of susceptibility and risk, as well as to reduce perceived barriers to screening, may effectively increase adherence to recommendations for LCS among high-risk Korean men.

Citations

Citations to this article as recorded by  
  • Factors influencing the intention for lung cancer screening in high-risk populations for lung cancer
    Mi-Kyoung Cho, Yoon Hee Cho
    Asia-Pacific Journal of Oncology Nursing.2024; 11(1): 100332.     CrossRef
  • Screening behaviors of high-risk individuals for lung cancer: A cross-sectional study
    Yu-An Lin, Xiujing Lin, Yonglin Li, Fangfang Wang, Rachel Arbing, Weiti Chen, Feifei Huang
    Asia-Pacific Journal of Oncology Nursing.2024; 11(4): 100402.     CrossRef
  • Speed and efficiency: evaluating pulmonary nodule detection with AI-enhanced 3D gradient echo imaging
    Sebastian Ziegelmayer, Alexander W. Marka, Maximilian Strenzke, Tristan Lemke, Hannah Rosenkranz, Bernadette Scherer, Thomas Huber, Kilian Weiss, Marcus R. Makowski, Dimitrios C. Karampinos, Markus Graf, Joshua Gawlitza
    European Radiology.2024;[Epub]     CrossRef
  • A Health Inequity: Associations Between Cigarette Smoking Status and Mammogram Screening Among Women of Color
    Danielle H Llaneza, Hanjoe Kim, Virmarie Correa-Fernández
    Nicotine & Tobacco Research.2023; 25(1): 66.     CrossRef
  • Motivation, acceptability and attitudes toward lung cancer screening among persons who attend a tobacco cessation program: A multicenter survey in Italy
    Olivera Djuric, Paolo Giorgi Rossi, Elena Camelia Ivanciu, Salvatore Cardellicchio, Chiara Cresci, Laura Carozzi, Francesco Pistelli, Valentina Bessi, Patrizia Gai, Valentina Galli, Giacomo Lavacchini, Claudia Bricci, Giuseppe Gorini, Sandra Bosi, Eugenio
    Preventive Medicine Reports.2023; 35: 102272.     CrossRef
  • Temporal Evolution and Associated Factors of Adherence to Mammography Screening among Women in Spain: Results from Two National Health Surveys (2017–2020)
    Silvia Portero de la Cruz, Luis M. Béjar, Jesús Cebrino
    Healthcare.2023; 11(22): 2934.     CrossRef
  • Cross-Cultural Adaptation of Lung Cancer Screening Health Belief Scale in Chinese Americans: A Methodological Study
    Fang Lei, Wei-Ti Chen, Mary-Lynn Brecht, Zuo-Feng Zhang, Yuhe Hu, Tuzhen Xu, Siqian Wang, Eunice Lee
    Journal of Nursing Measurement.2023; 31(4): 489.     CrossRef
  • Adaptation and validation of the Chinese version of the lung cancer screening health belief scales
    Yu-an Lin, Lisa Carter-Harris, Jia-ni Yang, Xiu jing Lin, Fei fei Huang
    BMC Public Health.2022;[Epub]     CrossRef
  • Barriers and facilitators to uptake of lung cancer screening: A mixed methods systematic review
    Yu-an Lin, Yu ting Hong, Xiu jing Lin, Jia ling Lin, Hui min Xiao, Fei fei Huang
    Lung Cancer.2022; 172: 9.     CrossRef
  • Promoting Community Awareness of Lung Cancer Screening Among Disparate Populations
    Lovoria B. Williams, Stephen W. Looney, Thomas Joshua, Amber McCall, Martha S. Tingen
    Cancer Nursing.2021; 44(2): 89.     CrossRef
  • Evaluating Knowledge, Attitudes, and Beliefs About Lung Cancer Screening Using Crowdsourcing
    John Monu, Matthew Triplette, Douglas E. Wood, Erika M. Wolff, Danielle C. Lavallee, David R. Flum, Farhood Farjah
    Chest.2020; 158(1): 386.     CrossRef
  • Understanding the Associations between Smoking-Related Risk Perception, Interest in Quitting Smoking, and Interest in Lung Cancer Screening among Homeless Adult Smokers
    Pooja Agrawal, Matthew Taing, Tzu-An Chen, Sean Reuven, Michael Businelle, Darla Kendzor, Eric Bernicker, Lorraine Reitzel
    International Journal of Environmental Research and Public Health.2020; 17(23): 8817.     CrossRef
  • 10,459 View
  • 233 Download
  • 14 Web of Science
  • 12 Crossref
Close layer
Proximal Resection Margins: More Prognostic than Distal Resection Margins in Patients Undergoing Hilar Cholangiocarcinoma Resection
Tae Yoo, Sang-Jae Park, Sung-Sik Han, Seong Hoon Kim, Seung Duk Lee, Tae Hyun Kim, Soon-ae Lee, Sang Myung Woo, Woo Jin Lee, Eun Kyung Hong
Cancer Res Treat. 2018;50(4):1106-1113.   Published online November 16, 2017
DOI: https://doi.org/10.4143/crt.2017.320
AbstractAbstract PDFPubReaderePub
Purpose
Even though the therapeutic gold standard of hilar cholangiocarcinoma (HCCA) resection is cancer-free resection margin (RM), surgical treatment still remains challenging. This study evaluated the prognostic significance of RM status in resected HCCA patients and identified survival prognostic factors.
Materials and Methods
We reviewed records of 96 HCCA patients who underwent surgery from 2001 to 2012 and analyzed the RM status and prognostic factors that affecting survival.
Results
Negative RM (n=31, 33%) was significantly associated with better survival vs. positive RM (n=65, 67%) (mean survival time [MST], 33 months vs. 21 months; p=0.011). Margins with histological findings of non-dysplastic epithelium, low-grade dysplasia, and carcinoma in situ were not associated with survival differences (MST, 33 months vs. 33 months vs. 30 months; p=0.452), whereas positive margins were associated with poorer survival relative to carcinoma in situ (MST, 30 months vs. 21 months; p=0.050). Among patients with R0 resection, narrow (≤ 5 mm) and wide (> 5 mm) margins were not associated with survival differences (MST, 33 months vs. 30 months; p=0.234). Although positive proximal RM was associated with poorer survival compared to negative RM (MST, 19 vs. 33; p=0.002), no survival difference was observed between positive and negative distal RMs (MST, 30 vs. 33; p=0.628). Proximal RM positivity (hazard ratio [HR], 2.688; p=0.007) and nodal involvement (HR, 3.293; p < 0.001) were independent survival prognostic factors.
Conclusion
A clear RM, especially proximal RM status, was significant prognosticator, and proximal bile duct resection to the greatest technically feasible extent may be necessary, with careful consideration of the potential morbidity and oncologic outcomes after resection. However, an aggressive approach to obtain a negative distal RM might be controversial and should be considered carefully, depending on the patient's status.

Citations

Citations to this article as recorded by  
  • Radiographic features predictive of recurrence and survival after surgical resection of perihilar cholangiocarcinoma
    Julaluck Promsorn, Panjaporn Naknan, Aumkhae Sookprasert, Kosin Wirasorn, Jarin Chindaprasirt, Attapol Titapun, Piyapharom Intarawichian, Mukesh Harisinghani
    Heliyon.2024; 10(7): e28805.     CrossRef
  • Practice guidelines for managing extrahepatic biliary tract cancers
    Hyung Sun Kim, Mee Joo Kang, Jingu Kang, Kyubo Kim, Bohyun Kim, Seong-Hun Kim, Soo Jin Kim, Yong-Il Kim, Joo Young Kim, Jin Sil Kim, Haeryoung Kim, Hyo Jung Kim, Ji Hae Nahm, Won Suk Park, Eunkyu Park, Joo Kyung Park, Jin Myung Park, Byeong Jun Song, Yong
    Annals of Hepato-Biliary-Pancreatic Surgery.2024; 28(2): 161.     CrossRef
  • Influence of Perineural (Pn), Lymphangio (L) and Vascular (V) Invasion on Survival after Resection of Perihilar Cholangiocarcinoma
    Rabea Margies, Lisa-Katharina Gröger, Beate K. Straub, Fabian Bartsch, Hauke Lang
    Cancers.2024; 16(20): 3463.     CrossRef
  • Liver transplantation for unresectable Klatskin tumor: experience of two centers, first distant results
    D. A. Granov, V. N. Zhuikov, I. I. Tileubergenov, A. V. Moiseenko, I. O. Rutkin, A. R. Sheraliev, A. A. Polikarpov, O. O. Rummo, A. E. Shcherba, I. P. Shturich, S. V. Korotkov, L. V. Kirkovsky, T. M. Chernishov
    Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery.2024; 29(3): 70.     CrossRef
  • Molecular profiling and prognostic analysis in Chinese cholangiocarcinoma: an observational, retrospective single-center study
    Changkun Zhang, Xia You, Qin Zhang, Dong Wang
    Investigational New Drugs.2023;[Epub]     CrossRef
  • Significance of dysplasia in bile duct resection margin in patients with extrahepatic cholangiocarcinoma: A retrospective analysis
    Jung Wan Choe, Hyo Jung Kim, Jae Seon Kim
    World Journal of Clinical Cases.2022; 10(10): 3078.     CrossRef
  • Klatskin Tumor: A Survival Analysis According to Tumor Characteristics and Inflammatory Ratios
    Vlad-Ionuţ Nechita, Emil Moiş, Luminiţa Furcea, Mihaela-Ancuţa Nechita, Florin Graur
    Medicina.2022; 58(12): 1788.     CrossRef
  • Impact of Remnant Carcinoma in Situ at the Ductal Stump on Long‐Term Outcomes in Patients with Distal Cholangiocarcinoma
    Koya Yasukawa, Akira Shimizu, Hiroaki Motoyama, Koji Kubota, Tsuyoshi Notake, Kentaro Fukushima, Tomohiko Ikehara, Hikaru Hayashi, Akira Kobayashi, Yuji Soejima
    World Journal of Surgery.2021; 45(1): 291.     CrossRef
  • Comprehensive analysis of genomic alterations of Chinese hilar cholangiocarcinoma patients
    Feiling Feng, Xiaobing Wu, Xiaoliang Shi, Qingxiang Gao, Yue Wu, Yong Yu, Qingbao Cheng, Bin Li, Bin Yi, Chen Liu, Qing Hao, Lin Zhang, Chunfang Gao, Xiaoqing Jiang
    International Journal of Clinical Oncology.2021; 26(4): 717.     CrossRef
  • Prognostic Impact of Perioperative CA19-9 Levels in Patients with Resected Perihilar Cholangiocarcinoma
    Jong Woo Lee, Jae Hoon Lee, Yejong Park, Jaewoo Kwon, Woohyung Lee, Ki Byung Song, Dae Wook Hwang, Song Cheol Kim
    Journal of Clinical Medicine.2021; 10(7): 1345.     CrossRef
  • Prognostic Predictability of American Joint Committee on Cancer 8th Staging System for Perihilar Cholangiocarcinoma: Limited Improvement Compared with the 7th Staging System
    Jong Woo Lee, Jae Hoon Lee, Yejong Park, Woohyung Lee, Jaewoo Kwon, Ki Byung Song, Dae Wook Hwang, Song Cheol Kim
    Cancer Research and Treatment.2020; 52(3): 886.     CrossRef
  • Comparative study of laparoscopic‐assisted and open total gastrectomy for Siewert Types II and III adenocarcinoma of the esophagogastric junction
    Jianchu Wang, Jin‐Cheng Wang, Bin Song, Xu‐Dong Dai, Xiao‐Yu Zhang
    Journal of Cellular Physiology.2019; 234(7): 11235.     CrossRef
  • Surgical management of carcinoma in situ at ductal resection margins in patients with extrahepatic cholangiocarcinoma
    Toshifumi Wakai, Jun Sakata, Tomohiro Katada, Yuki Hirose, Daiki Soma, Pankaj Prasoon, Kohei Miura, Takashi Kobayashi
    Annals of Gastroenterological Surgery.2018; 2(5): 359.     CrossRef
  • 8,513 View
  • 243 Download
  • 18 Web of Science
  • 13 Crossref
Close layer
Effect of Smoking Cessation and Reduction on the Risk of Cancer in Korean Men: A Population Based Study
Seulggie Choi, Jooyoung Chang, Kyuwoong Kim, Sang Min Park, Kiheon Lee
Cancer Res Treat. 2018;50(4):1114-1120.   Published online November 24, 2017
DOI: https://doi.org/10.4143/crt.2017.326
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The purpose of this study was to investigate the effect of smoking habit change on the risk of cancer.
Materials and Methods
From the Korean National Health Insurance Service database, we determined the change in smoking habit between the first (2002 and 2003) and second (2004 and 2005) health examination periods. A total of 143,071 men were categorized into baseline heavy (≥ 20 cigarettes per day), moderate (10-19 cigarettes per day), light (< 10 cigarettes per day) smokers, quitters, and never smokers, after which the change in smoking status was determined during the second health examination. The participants were then followed up from 2006 to 2013 for all cancer, smoking related cancer, and lung cancer.
Results
Compared to heavy continual smokers, heavy smokers who quit had reduced risk of smoking related cancer (hazard ratio [HR], 0.74; 95% confidence interval [CI], 0.56 to 0.97) and tended to have reduced risk of all cancer (HR, 0.87; 95% CI, 0.75 to 1.00). Moderate smokers who reduced the amount of smoking to light levels had decreased risk of all cancer (HR, 0.82; 95% CI, 0.72 to 0.94), smoking related cancer (HR, 0.74; 95% CI, 0.59 to 0.93), and lung cancer (HR, 0.55; 95% CI, 0.38 to 0.79) compared to heavy continual smokers.
Conclusion
Smoking reduction decreases the risk of all cancer, smoking related cancer, and lung cancer. While smoking cessation should be the treatment of choice for smokers, smoking reduction may serve as an alternative strategy for those who cannot quit.

Citations

Citations to this article as recorded by  
  • Cancer Risk Following Smoking Cessation in Korea
    Eunjung Park, Hee-Yeon Kang, Min Kyung Lim, Byungmi Kim, Jin-Kyoung Oh
    JAMA Network Open.2024; 7(2): e2354958.     CrossRef
  • Impact of smoking reduction on lung cancer risk in patients with COPD who smoked fewer than 30 pack-years: a nationwide population-based cohort study
    Sun Hye Shin, Taeyun Kim, Hyunsoo Kim, Juhee Cho, Danbee Kang, Hye Yun Park
    Respiratory Research.2024;[Epub]     CrossRef
  • Changes in smoking use and subsequent lung cancer risk in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study
    Daniela S Gutiérrez-Torres, Sungduk Kim, Demetrius Albanes, Stephanie J Weinstein, Maki Inoue-Choi, Paul S Albert, Neal D Freedman
    JNCI: Journal of the National Cancer Institute.2024; 116(6): 895.     CrossRef
  • Global epidemiology of early‐onset upper gastrointestinal cancer: trend from the Global Burden of Disease Study 2019
    Pojsakorn Danpanichkul, Thanida Auttapracha, Siwanart Kongarin, Ben Ponvilawan, Daniel M. Simadibrata, Kwanjit Duangsonk, Supitchaya Jaruvattanadilok, Sakditad Saowapa, Kanokphong Suparan, Rashid N. Lui, Suthat Liangpunsakul, Michael B. Wallace, Karn Wija
    Journal of Gastroenterology and Hepatology.2024; 39(9): 1856.     CrossRef
  • Smoking cessation rate and predictors of successful quitting in Jordan: A cross-sectional study
    Nuha W. Qasem, Batool H. Al-Omoush, Sami K. Altbeinat, Moutasem M. Al-Dlaijem, Reham I. Salahat, Samer A. Okour
    Medicine.2024; 103(27): e38708.     CrossRef
  • Smoking-attributable Mortality in Korea, 2020: A Meta-analysis of 4 Databases
    Eunsil Cheon, Yeun Soo Yang, Suyoung Jo, Jieun Hwang, Keum Ji Jung, Sunmi Lee, Seong Yong Park, Kyoungin Na, Soyeon Kim, Sun Ha Jee, Sung-il Cho
    Journal of Preventive Medicine and Public Health.2024; 57(4): 327.     CrossRef
  • Passive smoking and risk of pancreatic cancer: an updated systematic review and meta-analysis
    Xudong Wang, Zihan Wang, Xujie Wang
    PeerJ.2024; 12: e18017.     CrossRef
  • Body mass index, waist circumference and cardiovascular diseases in transitional ages (40 and 66 years)
    Jung Eun Yoo, Kyungdo Han, Jin‐Hyung Jung, Yang‐Im Hur, Yang Hyun Kim, Eun Sook Kim, Jang Won Son, Eun‐Jung Rhee, Won‐Young Lee, Ga Eun Nam
    Journal of Cachexia, Sarcopenia and Muscle.2023; 14(1): 369.     CrossRef
  • Latency period of aristolochic acid-induced upper urinary tract urothelial carcinoma
    Jing-Rong Jhuang, Po-Chun Chiu, Tung-Che Hsieh, Chung-Hsin Chen, Yeong-Shiau Pu, Wen-Chung Lee
    Frontiers in Public Health.2023;[Epub]     CrossRef
  • Association between smoking and obstructive sleep apnea based on the STOP-Bang index
    Yun Seo Jang, Nataliya Nerobkova, Kyungduk Hurh, Eun-Cheol Park, Jaeyong Shin
    Scientific Reports.2023;[Epub]     CrossRef
  • The effects of smoking habit change on the risk of depression–Analysis of data from the Korean National Health Insurance Service
    Ga Eun Kim, Min-ho Kim, Weon-Jeon Lim, Soo In Kim
    Journal of Affective Disorders.2022; 302: 293.     CrossRef
  • Effect of smoking reduction, cessation, and resumption on cancer risk: A nationwide cohort study
    Jung Eun Yoo, Kyungdo Han, Dong Wook Shin, Wonyoung Jung, Dahye Kim, Cheol Min Lee, Hyuktae Kwon, Kyu‐Won Jung, Yun‐Mi Song
    Cancer.2022; 128(11): 2126.     CrossRef
  • Psychosocial stress and cancer risk: a narrative review
    Ananyaa Mohan, Inge Huybrechts, Nathalie Michels
    European Journal of Cancer Prevention.2022; 31(6): 585.     CrossRef
  • Smoking trajectory and cancer risk: A population-based cohort study
    Minh Luu, Minji Han, Tra Bui, Phuong Thao Tran, Min-Kyung Lim, Jin Oh
    Tobacco Induced Diseases.2022; 20(August): 1.     CrossRef
  • Longitudinal Changes in Smoking Habits in Women and Subsequent Risk of Cancer
    Thi Xuan Mai Tran, Soyeoun Kim, Huiyeon Song, Boyoung Park
    American Journal of Preventive Medicine.2022; 63(6): 894.     CrossRef
  • Health promotion: the essence of primary healthcare
    Sung Sunwoo
    Journal of the Korean Medical Association.2022; 65(12): 772.     CrossRef
  • Cigarette Smoking Reduction and Health Risks: A Systematic Review and Meta-analysis
    Joanne T Chang, Gabriella M Anic, Brian L Rostron, Manju Tanwar, Cindy M Chang
    Nicotine & Tobacco Research.2021; 23(4): 635.     CrossRef
  • Decreased Levels of Soluble CD44 in a High-Risk Population following a Smoking Cessation Program
    Drew H. Smith, Shahm Raslan, Isildinha M. Reis, Abdurrahman Al-Awady, Isabella Buitron, Melanie Perez, Huaping Liu, Jerri Halgowich, Claudia Gordon, Monica Webb Hooper, Noël C. Barengo, Elizabeth J. Franzmann
    International Journal of Environmental Research and Public Health.2021; 18(24): 13174.     CrossRef
  • Exposure to oral bisphosphonates and risk of gastrointestinal cancer
    D. Choi, S. Choi, J. Chang, S. M. Park
    Osteoporosis International.2020; 31(4): 775.     CrossRef
  • Smoking Cessation Improves the Symptoms and the Findings of Laryngeal Irritation
    A. Secil Kayalı Dinc, Melih Cayonu, Tijen Sengezer, M. Melih Sahin
    Ear, Nose & Throat Journal.2020; 99(2): 124.     CrossRef
  • Association between Post-Diagnosis Particulate Matter Exposure among 5-Year Cancer Survivors and Cardiovascular Disease Risk in Three Metropolitan Areas from South Korea
    Seulggie Choi, Kyae Hyung Kim, Kyuwoong Kim, Jooyoung Chang, Sung Min Kim, Seong Rae Kim, Yoosun Cho, Gyeongsil Lee, Joung Sik Son, Sang Min Park
    International Journal of Environmental Research and Public Health.2020; 17(8): 2841.     CrossRef
  • Cigarette Smoking Is Associated with Increased Risk of Malignant Gliomas: A Nationwide Population-Based Cohort Study
    Stephen Ahn, Kyung-Do Han, Yong-Moon Park, Jung Min Bae, Sang Uk Kim, Sin-Soo Jeun, Seung Ho Yang
    Cancers.2020; 12(5): 1343.     CrossRef
  • The Association of Smoking Exposure at Home with Attempts to Quit Smoking and Cessation Success: A Survey of South Korean Adolescents Who Smoke
    Wonjeong Jeong, Yun Kyung Kim, Jae Hong Joo, Sung-In Jang, Eun-Cheol Park
    International Journal of Environmental Research and Public Health.2020; 17(11): 4129.     CrossRef
  • Exploring smoking cessation behaviors of outpatients in outpatient clinics
    Ching-Yi Hsu, Hung-En Liao, Li-Chun Huang
    Medicine.2020; 99(27): e20971.     CrossRef
  • UegWeek 2020 Poster Presentations

    United European Gastroenterology Journal.2020; 8(S8): 144.     CrossRef
  • Assessing the lung cancer risk reduction potential of candidate modified risk tobacco products
    Julia Hoeng, Serge Maeder, Patrick Vanscheeuwijck, Manuel C. Peitsch
    Internal and Emergency Medicine.2019; 14(6): 821.     CrossRef
  • Prevalence of tobacco related chronic diseases and its role in smoking cessation among smokers in a rural area of Shanghai, China: a cross sectional study
    Ruiping Wang, Yonggen Jiang, Chunxia Yao, Meiying Zhu, Qi Zhao, Limei Huang, Guimin Wang, Ying Guan, Engelgau Michael, Genming Zhao
    BMC Public Health.2019;[Epub]     CrossRef
  • Relationships between smoking duration, smoking intensity, hypothetical tobacco price increases, and smoking habit change intention among current smokers in Shanghai
    Ruiping Wang, Yonggen Jiang, Xin Li, Qi Zhao, Meiying Zhu, Ying Guan, Genming Zhao
    Journal of International Medical Research.2019; 47(10): 5216.     CrossRef
  • The impact of smoking cessation attempts on stress levels
    Seong-Jun Kim, Wonjeong Chae, Woo-Hyun Park, Min-Ho Park, Eun-Cheol Park, Sung-In Jang
    BMC Public Health.2019;[Epub]     CrossRef
  • 9,082 View
  • 308 Download
  • 30 Web of Science
  • 29 Crossref
Close layer
HBsAg-Negative, Anti-HBc–Negative Patients Still Have a Risk of Hepatitis B Virus–Related Hepatitis after Autologous Stem Cell Transplantation for Multiple Myeloma or Malignant Lymphoma
Hyunsung Park, Do Young Kim, Soo-Jeong Kim, Haerim Chung, Hyunsoo Cho, Ji Eun Jang, June-Won Cheong, Yoo Hong Min, Jae-Woo Song, Jin Seok Kim
Cancer Res Treat. 2018;50(4):1121-1129.   Published online December 4, 2017
DOI: https://doi.org/10.4143/crt.2017.329
AbstractAbstract PDFPubReaderePub
Purpose
Although hepatitis B surface antigen (HBsAg)–negative, hepatitis B core antibody (anti-HBc)–negative patients are not considered to be at risk for hepatitis B virus (HBV)–related hepatitis, the actual risk remains to be elucidated. This study aimed to evaluate the risk of HBV-related hepatitis in HBsAg-negative, anti-HBc–negative patients receiving autologous stem cell transplantation (ASCT) for multiple myeloma (MM) or malignant lymphoma.
Materials and Methods
We retrospectively reviewed data from 271 HBsAg-negative patients (161 anti-HBc–negative and 110 anti-HBc–positive at the time of ASCT) who received ASCT for MM or lymphoma. The risk of HBV-related hepatitis was analyzed according to the presence of anti-HBc. HBV serology results at the time of ASCT were compared with those at the time of diagnosis of MM or lymphoma.
Results
Three patients (two anti-HBc–negative MMs and one anti-HBc–positive MM) developed HBV-related hepatitis after ASCT. The rate of HBV-related hepatitis did not differ among patients with or without anti-HBc status (p=0.843). HBV-related hepatitis more frequently occurred in MM patients than in lymphoma patients (p=0.041). Overall, 9.1% of patients (16.7% with MM and 5.4% with lymphoma) who were HBsAg–negative and anti-HBc–positive at the time of diagnosis had lost anti-HBc positivity during chemotherapy prior to ASCT.
Conclusion
Our data suggest that HBsAg-negative, anti-HBc–negative patients at the time of ASCT for MM or lymphoma still might be at a risk for HBV-related hepatitis.

Citations

Citations to this article as recorded by  
  • Seroreversion of hepatitis B surface antigen among subjects with resolved hepatitis B virus infection: A community‐based cohort study
    Ming‐Lun Yeh, Po‐Cheng Liang, Ching‐I Huang, Meng‐Hsuan Hsieh, Yi‐Hung Lin, Tyng‐Yuan Jang, Yu‐Ju Wei, Po‐Yao Hsu, Cheng‐Ting Hsu, Chih‐Wen Wang, Ming‐Yen Hsieh, Zu‐Yau Lin, Shinn‐Cherng Chen, Chung‐Feng Huang, Jee‐Fu Huang, Chia‐Yen Dai, Wan‐Long Chuang,
    Journal of Gastroenterology and Hepatology.2021; 36(11): 3239.     CrossRef
  • Seronegative occult HBV reactivation complicated with fulminant acute liver failure after rituximab for chronic inflammatory demyelinating polyneuropathy
    A. R. Buonomo, G. Viceconte, R. Scotto, M. De Angelis, S. Tozza, F. Manganelli, A. G. Lanza, G. G. Di Costanzo, I. Gentile
    Infectious Diseases.2020; 52(3): 216.     CrossRef
  • 9,265 View
  • 205 Download
  • 3 Web of Science
  • 2 Crossref
Close layer
Prognostic Factors and Decision Tree for Long-Term Survival in Metastatic Uveal Melanoma
Daniel Lorenzo, María Ochoa, Josep Maria Piulats, Cristina Gutiérrez, Luis Arias, Jaume Català, María Grau, Judith Peñafiel, Estefanía Cobos, Pere Garcia-Bru, Marcos Javier Rubio, Noel Padrón-Pérez, Bruno Dias, Joan Pera, Josep Maria Caminal
Cancer Res Treat. 2018;50(4):1130-1139.   Published online December 4, 2017
DOI: https://doi.org/10.4143/crt.2017.171
AbstractAbstract PDFPubReaderePub
Purpose
The purpose of this study was to demonstrate the existence of a bimodal survival pattern in metastatic uveal melanoma. Secondary aims were to identify the characteristics and prognostic factors associated with long-term survival and to develop a clinical decision tree.
Materials and Methods
The medical records of 99 metastatic uveal melanoma patients were retrospectively reviewed. Patients were classified as either short (≤ 12 months) or long-term survivors (> 12 months) based on a graphical interpretation of the survival curve after diagnosis of the first metastatic lesion. Ophthalmic and oncological characteristicswere assessed in both groups.
Results
Of the 99 patients, 62 (62.6%) were classified as short-term survivors, and 37 (37.4%) as long-term survivors. The multivariate analysis identified the following predictors of long-term survival: age ≤ 65 years (p=0.012) and unaltered serum lactate dehydrogenase levels (p=0.018); additionally, the size (smaller vs. larger) of the largest liver metastasis showed a trend towards significance (p=0.063). Based on the variables significantly associated with long-term survival, we developed a decision tree to facilitate clinical decision-making.
Conclusion
The findings of this study demonstrate the existence of a bimodal survival pattern in patients with metastatic uveal melanoma. The presence of certain clinical characteristics at diagnosis of distant disease is associated with long-term survival. A decision tree was developed to facilitate clinical decision-making and to counsel patients about the expected course of disease.

Citations

Citations to this article as recorded by  
  • A Systematic Review of Prognostic Factors in Patients with Cancer Receiving Palliative Radiotherapy: Evidence-Based Recommendations
    Alexander Tam, Emanuela Scarpi, Marco Cesare Maltoni, Romina Rossi, Alysa Fairchild, Kristopher Dennis, Marcus Vaska, Marc Kerba
    Cancers.2024; 16(9): 1654.     CrossRef
  • Comparative assessment of the capability of machine learning-based radiomic models for predicting omental metastasis in locally advanced gastric cancer
    Ahao Wu, Lianghua Luo, Qingwen Zeng, Changlei Wu, Xufeng Shu, Pang Huang, Zhonghao Wang, Tengcheng Hu, Zongfeng Feng, Yi Tu, Yanyan Zhu, Yi Cao, Zhengrong Li
    Scientific Reports.2024;[Epub]     CrossRef
  • Impact of Metastatic Pattern on Survival in Patients with Posterior Uveal Melanoma: A Retrospective Cohort Study
    Tine G. Hindso, Peter S. Jensen, Mette B. Sjøl, Kristoffer Nissen, Camilla W. Bjerrum, Eric von Benzon, Carsten Faber, Steen F. Urbak, Marco Donia, Inge M. Svane, Eva Ellebaek, Steffen Heegaard, Karine Madsen, Jens F. Kiilgaard
    Cancers.2024; 16(19): 3346.     CrossRef
  • Orthotopic murine xenograft model of uveal melanoma with spontaneous liver metastasis
    Raquel Ramos, Eduard Cabré, Antònia Vinyals, Daniel Lorenzo, Josep R. Ferreres, Mar Varela, Montse Gomá, Maria José Paules, Cristina Gutierrez, Josep M. Piulats, Àngels Fabra, José M. Caminal
    Melanoma Research.2023; 33(1): 1.     CrossRef
  • Determinants of Long-Term Survival in Metastatic Choroidal and Ciliary Body Melanoma
    Elina S. Rantala, Raffaele Parrozzani, Micaela M. Hernberg, Vanna Chiarion-Sileni, Tero T. Kivelä, Edoardo Midena
    American Journal of Ophthalmology.2023; 246: 258.     CrossRef
  • Development and validation of machine learning models for predicting prognosis and guiding individualized postoperative chemotherapy: A real-world study of distal cholangiocarcinoma
    Di Wang, Bing Pan, Jin-Can Huang, Qing Chen, Song-Ping Cui, Ren Lang, Shao-Cheng Lyu
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Applications of Artificial Intelligence in Ocular Oncology
    Bhavna Chawla, Kusumitha B. Ganesh
    Advances in Ophthalmology and Optometry.2023; 8(1): 111.     CrossRef
  • Differences in glucose metabolic activity in liver metastasis separates two groups of metastatic uveal melanoma patients with different prognosis
    Luis P. del Carpio, María Asunción Algarra, Aida Sabaté‐Llobera, Alejo Rodriguez‐Vida, Susana Rossi‐Seoane, Sandra Ruiz, David Leiva, Emilio Ramos, Laura Lladò, Daniel Lorenzo, Cristina Gutierrez, Montserrat Cortes‐Romera, Josep M. Caminal, Josep M. Piula
    Cancer Medicine.2023; 12(13): 14062.     CrossRef
  • Patients presenting with metastases: stage IV uveal melanoma, an international study
    Gaurav Garg, Paul T Finger, Tero T Kivelä, E Rand Simpson, Brenda L Gallie, Svetlana Saakyan, Anush G Amiryan, Vladimir Valskiy, Kimberly J Chin, Ekaterina Semenova, Stefan Seregard, Maria Filì, Matthew Wilson, Barrett Haik, Josep Maria Caminal, Jaume Cat
    British Journal of Ophthalmology.2022; 106(4): 510.     CrossRef
  • Metastatic uveal melanoma: The final frontier
    Elina S. Rantala, Micaela M. Hernberg, Sophie Piperno-Neumann, Hans E. Grossniklaus, Tero T. Kivelä
    Progress in Retinal and Eye Research.2022; 90: 101041.     CrossRef
  • The Application of Artificial Intelligence in the Analysis of Biomarkers for Diagnosis and Management of Uveitis and Uveal Melanoma: A Systematic Review
    Arshpreet Bassi, Saffire H Krance, Aidan Pucchio, Daiana R Pur, Rafael N Miranda, Tina Felfeli
    Clinical Ophthalmology.2022; Volume 16: 2895.     CrossRef
  • A Multimodal Approach to Discover Biomarkers for Taxane-Induced Peripheral Neuropathy (TIPN): A Study Protocol
    Anukriti Sharma, Ken B. Johnson, Bihua Bie, Emily E. Rhoades, Alper Sen, Yuri Kida, Jennifer Hockings, Alycia Gatta, Jacqueline Davenport, Connie Arcangelini, Jennifer Ritzu, Jennifer DeVecchio, Ron Hughen, Mei Wei, G. Thomas Budd, N. Lynn Henry, Charis E
    Technology in Cancer Research & Treatment.2022;[Epub]     CrossRef
  • Nomogram, Decision Tree and Deep Learning Models to Predict Lymph Node Metastasis of Patients with Early Gastric Cancer: A Multi-Cohort Study
    Lulu Zhao, Weili Han, Penghui Niu, Yuanyuan Lu, Fan Zhang, Fuzhi Jiao, Xiadong Zhou, Wanqing Wang, Xiaoyi Luan, Mingyan He, Quanlin Guan, Yu-min Li, Yongzhan Nie, Kaichun Wu, Yingtai Chen
    SSRN Electronic Journal.2022;[Epub]     CrossRef
  • ALKBH5-mediated m6A demethylation of FOXM1 mRNA promotes progression of uveal melanoma
    Lili Hao, Jiayang Yin, Hong Yang, Chaoxuan Li, Linxin Zhu, Lian Liu, Jingxiang Zhong
    Aging.2021; 13(3): 4045.     CrossRef
  • Impact of staging on survival outcomes: a nationwide real-world cohort study of metastatic uveal melanoma
    Elina S. Rantala, Tero T. Kivelä, Micaela M. Hernberg
    Melanoma Research.2021; 31(3): 224.     CrossRef
  • Classification trees for predicting obesity in school-aged children
    E.V. Anufrieva, V.N. Shershnev, O.P. Kovtun
    Profilakticheskaya meditsina.2021; 24(7): 30.     CrossRef
  • Choroidal Melanoma with Ultrasound-Guided Episcleral Brachytherapy: Long-Term Results and Risk of Metastasis
    Beatriz Quiles, Jorge Mataix, José Luis Guinot, Isabel Wang, Victor De los Dolores, Marina Peña, Alonso La Rosa, Maribel Tortajada, Miguel Santos, Leoncio Arribas
    Ocular Oncology and Pathology.2021; 7(4): 280.     CrossRef
  • Development of a Prognostic Nomogram for Liver Metastasis of Uveal Melanoma Patients Selected by Liver MRI
    Pascale Mariani, Sylvain Dureau, Alexia Savignoni, Livia Lumbroso-Le Rouic, Christine Levy-Gabriel, Sophie Piperno-Neumann, Manuel J. Rodrigues, Laurence Desjardins, Nathalie Cassoux, Vincent Servois
    Cancers.2019; 11(6): 863.     CrossRef
  • Iterative treatment with surgery and radiofrequency ablation of uveal melanoma liver metastasis: Retrospective analysis of a series of very long-term survivors
    Vincent Servois, Toufik Bouhadiba, Sylvain Dureau, Carla Da Costa, Mohamed Maher Almubarak, Romain Foucher, Alexia Savignoni, Nathalie Cassoux, Gaelle Pierron, Pascale Mariani
    European Journal of Surgical Oncology.2019; 45(9): 1717.     CrossRef
  • 9,097 View
  • 272 Download
  • 21 Web of Science
  • 19 Crossref
Close layer
A Novel Prognostic Nomogram for Predicting Risks of Distant Failure in Patients with Invasive Breast Cancer Following Postoperative Adjuvant Radiotherapy
Yu Jin Lim, Sea-Won Lee, Noorie Choi, Jeanny Kwon, Keun-Yong Eom, Eunyoung Kang, Eun-Kyu Kim, Jee Hyun Kim, Yu Jung Kim, Se Hyun Kim, So Yeon Park, In Ah Kim
Cancer Res Treat. 2018;50(4):1140-1148.   Published online December 7, 2017
DOI: https://doi.org/10.4143/crt.2017.508
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
This study aimed to identify predictors for distant metastatic behavior and build a related prognostic nomogram in breast cancer.
Materials and Methods
A total of 1,181 patients with non-metastatic breast cancer between 2003 and 2011 were analyzed. To predict the probability of distant metastasis, a nomogram was constructed based on prognostic factors identified using a Cox proportional hazards model.
Results
The 7-year overall survival and 5-year post-progression survival of locoregional versus distant recurrence groups were 67.6% versus 39.1% (p=0.027) and 54.2% versus 33.5% (p=0.043), respectively. Patients who developed distant metastasis showed early and late mortality risk peaks within 3 and after 5 years of follow-up, respectively, but a broad and low risk increment was observed in other patients with locoregional relapse. In multivariate analysis of distant metastasis-free interval, age (≥ 45 years vs. < 45 years), molecular subtypes (luminal A vs. luminal B, human epidermal growth receptor 2, and triple negative), T category (T1 vs. T2-3 and T4), and N category (N0 vs. N1 and N2-3) were independently associated (p < 0.05 for all). Regarding the significant factors, a well-validated nomogram was established (concordance index, 0.812). The risk score level of patients with initial brain failure was higher than those of non-brain sites (p=0.029).
Conclusion
The nomogram could be useful for predicting the individual probability of distant recurrence in breast cancer. In high-risk patients based on the risk scores, more aggressive systemic therapy and closer surveillance for metastatic failure should be considered.

Citations

Citations to this article as recorded by  
  • Predicting Patterns of Distant Metastasis in Breast Cancer Patients following Local Regional Therapy Using Machine Learning
    Audrey Shiner, Alex Kiss, Khadijeh Saednia, Katarzyna J. Jerzak, Sonal Gandhi, Fang-I Lu, Urban Emmenegger, Lauren Fleshner, Andrew Lagree, Marie Angeli Alera, Mateusz Bielecki, Ethan Law, Brianna Law, Dylan Kam, Jonathan Klein, Christopher J. Pinard, Ale
    Genes.2023; 14(9): 1768.     CrossRef
  • Nomograms for Predicting Specific Distant Metastatic Sites and Overall Survival of Breast Invasive Ductal Carcinoma Patients After Surgery: A Large Population-Based Study
    Yuqian Feng, Yiting Zhang, Yuying Xiang, Kaibo Guo, Huimin Jin, Shanming Ruan, Zhuoya Guan
    Frontiers in Surgery.2022;[Epub]     CrossRef
  • Cost-effectiveness of postmastectomy hypofractionated radiation therapy vs conventional fractionated radiation therapy for high-risk breast cancer
    Jing Yang, Shu-Nan Qi, Hui Fang, Yong-Wen Song, Jing Jin, Yue-Ping Liu, Wei-Hu Wang, Yong Yang, Yu Tang, Hua Ren, Bo Chen, Ning-Ning Lu, Yuan Tang, Ning Li, Hao Jing, Shu-Lian Wang, Ye-Xiong Li
    The Breast.2021; 58: 72.     CrossRef
  • Prediction of distant metastatic recurrence by tumor-infiltrating lymphocytes in hormone receptor-positive breast cancer
    Koji Takada, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Rika Kouhashi, Akimichi Yabumoto, Sae Ishihara, Tamami Morisaki, Masatsune Shibutani, Hiroaki Tanaka, Kosei Hirakawa, Masaichi Ohira
    BMC Women's Health.2021;[Epub]     CrossRef
  • Nomogram for the personalisation of radiotherapy treatments in breast cancer patients
    Inmaculada Beato Tortajada, Carlos Ferrer Albiach, Virginia Morillo Macias
    The Breast.2021; 60: 255.     CrossRef
  • Prognostic Factors and Nomograms to Predict Overall and Cancer-Specific Survival for Children with Wilms’ Tumor
    Fucai Tang, Hanbin Zhang, Zechao Lu, Jiamin Wang, Chengwu He, Zhaohui He
    Disease Markers.2019; 2019: 1.     CrossRef
  • Score for the Survival Probability in Metastasis Breast Cancer: A Nomogram-Based Risk Assessment Model
    Zhenchong Xiong, Guangzheng Deng, Xinjian Huang, Xing Li, Xinhua Xie, Jin Wang, Zeyu Shuang, Xi Wang
    Cancer Research and Treatment.2018; 50(4): 1260.     CrossRef
  • 9,108 View
  • 233 Download
  • 11 Web of Science
  • 7 Crossref
Close layer
Effect of Adjuvant Chemotherapy on Stage II Colon Cancer: Analysis of Korean National Data
Min Ki Kim, Daeyoun David Won, Sun Min Park, Taejung Kim, Sung Ryong Kim, Seong Taek Oh, Seung Kook Sohn, Mi Yeon Kang, In Kyu Lee
Cancer Res Treat. 2018;50(4):1149-1163.   Published online December 7, 2017
DOI: https://doi.org/10.4143/crt.2017.194
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Debates exist regarding the effectiveness of adjuvant chemotherapy for stage II colon cancer. This study aimed to investigate the current status of adjuvant chemotherapy and its impact on survival for Korean stage II colon cancer patients by analyzing the National Quality Assessment data.
Materials and Methods
A total of 7,880 patientswho underwent curative resection for stage II colon adenocarcinoma between January 2011 andDecember 2014 in Koreawere selected randomly as evaluation subjects for the quality assessment. The factors that influenced overall survival were identified. The high-risk group was defined as having at least one of the following: perforation/ obstruction, lymph node harvest less than 12, lymphovascular/perineural invasion, positive resection margin, poor differentiation, or pathologic T4 stage.
Results
The median follow-up period was 38 months (range, 1 to 63 months). Chemotherapy was a favorable prognostic factor for either the high- (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.38 to 0.59; p < 0.001) or low-risk group (HR, 0.74; 95% CI, 0.61 to 0.89; p=0.002) in multivariate analysis. This was also the case in patients over 70 years of age. The hazard ratio was significantly increased as the number of involved risk factors was increased in patients who didn’t receive chemotherapy. Adding oxaliplatin showed no difference in survival (HR, 1.36; 95% CI, 0.91 to 2.03; p=0.132).
Conclusion
Adjuvant chemotherapy can be recommended for stage II colon cancer patients, but the addition of oxaliplatin to the regimen must be selective.

Citations

Citations to this article as recorded by  
  • Colon cancer: the 2023 Korean clinical practice guidelines for diagnosis and treatment
    Hyo Seon Ryu, Hyun Jung Kim, Woong Bae Ji, Byung Chang Kim, Ji Hun Kim, Sung Kyung Moon, Sung Il Kang, Han Deok Kwak, Eun Sun Kim, Chang Hyun Kim, Tae Hyung Kim, Gyoung Tae Noh, Byung-Soo Park, Hyeung-Min Park, Jeong Mo Bae, Jung Hoon Bae, Ni Eun Seo, Cha
    Annals of Coloproctology.2024; 40(2): 89.     CrossRef
  • Postoperative chemotherapy use and survival in non-high-risk young and high-risk old-aged patients with stage II colon cancer
    Tian Jin, Yingshuang Zhu, Wei Lu, Chenqin Le, Lijuan Wang, Qian Xiao, Kefeng Ding
    Holistic Integrative Oncology.2023;[Epub]     CrossRef
  • Risk factors for recurrence in elderly patients with stage II colorectal cancer: a multicenter retrospective study
    Takuki Yagyu, Manabu Yamamoto, Akimitsu Tanio, Kazushi Hara, Ken Sugezawa, Chihiro Uejima, Kyoichi Kihara, Shigeru Tatebe, Yasuro Kurisu, Shunsuke Shibata, Toshio Yamamoto, Hiroshi Nishie, Setsujo Shiota, Hiroaki Saito, Takuji Naka, Kenji Sugamura, Kuniyu
    BMC Cancer.2022;[Epub]     CrossRef
  • The role of high-risk features in stage II colon cancer after surgical treatment
    Patricio Bernardo Lynn, Garrett Yoon, Terry Li, Meng Cao, Michael Grieco, H. Leon Pachter, Russell C. Langan, Patrick Hilden, Joanna Sesti, Jason Maggi
    Surgery Open Digestive Advance.2022; 7: 100054.     CrossRef
  • Survival impact of adjuvant chemotherapy in patients with stage IIA colon cancer: Analysis of the National Cancer Database
    Pietro Achilli, Jacopo Crippa, Fabian Grass, Kellie L. Mathis, Anne‐Lise D. D'Angelo, Mohamed A. Abd El Aziz, Courtney N. Day, William S. Harmsen, David W. Larson
    International Journal of Cancer.2021; 148(1): 161.     CrossRef
  • Associations of P Score With Real-World Survival Improvement Offered by Adjuvant Chemotherapy in Stage II Colon Cancer: A Large Population-Based Longitudinal Cohort Study
    Qi Liu, Zezhi Shan, Dakui Luo, Sheng Zhang, Qingguo Li, Xinxiang Li
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer
    Qi Wu, Zhiyuan Zhang, Yijiao Chen, Jiang Chang, Yudong Jiang, Dexiang Zhu, Ye Wei
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Effect of Adjuvant Chemotherapy on Elderly Stage II High-Risk Colorectal Cancer Patients
    Yujin Lee, Inseok Park, Hyunjin Cho, Geumhee Gwak, Keunho Yang, Byung-Noe Bae
    Annals of Coloproctology.2021; 37(5): 298.     CrossRef
  • Elderly High-Risk Stage II Colorectal Cancer Patients: Candidates for Improving Outcome?
    Min Ki Kim
    Annals of Coloproctology.2021; 37(5): 267.     CrossRef
  • Efficacy and tolerability of adjuvant therapy in ≥70-year-old patients with T3N0M0 colorectal cancer: An observational study
    Abdullah Sakin, Nurgul Yasar, Suleyman Sahin, Serdar Arici, Saban Secmeler, Orcun Can, Caglayan Geredeli, Cumhur Demir, Sener Cihan
    Journal of Oncology Pharmacy Practice.2020; 26(3): 619.     CrossRef
  • Postoperative chemotherapy improves survival in patients with resected high‐risk Stage II colorectal cancer: results of a systematic review and meta‐analysis
    C. Simillis, H. K. S. I. Singh, T. Afxentiou, S. Mills, O. J. Warren, J. J. Smith, P. Riddle, M. Adamina, D. Cunningham, P. P. Tekkis
    Colorectal Disease.2020; 22(10): 1231.     CrossRef
  • Patient Selection for Adjuvant Chemotherapy in High-Risk Stage II Colon Cancer
    Chao Zhang, Songcheng Yin, Yuen Tan, Jinyu Huang, Pengliang Wang, Wenbin Hou, Zhe Zhang, Huimian Xu
    American Journal of Clinical Oncology.2020; 43(4): 279.     CrossRef
  • Mucinous Histology Might Be an Indicator for Enhanced Survival Benefit of Chemotherapy in Stage II Colon Cancer
    Yong Huang, Kuanxue Ge, Guangshun Fu, Junfeng Chu, Wei Wei
    Frontiers in Medicine.2020;[Epub]     CrossRef
  • Re-Evaluation of the Survival Paradox Between Stage IIB/IIC and Stage IIIA Colon Cancer
    Hongbo Li, Guangshun Fu, Wei Wei, Yong Huang, Zhenguang Wang, Tao Liang, Shuyun Tian, Honggang Chen, Wei Zhang
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Evaluating the Guiding Role of Elevated Pretreatment Serum Carcinoembryonic Antigen Levels for Adjuvant Chemotherapy in Stage IIA Colon Cancer: A Large Population-Based and Propensity Score-Matched Study
    Qi Liu, Yongqiang Huang, Dakui Luo, Sheng Zhang, Sanjun Cai, Qingguo Li, Yanlei Ma, Xinxiang Li
    Frontiers in Oncology.2019;[Epub]     CrossRef
  • Adjuvant chemotherapy does not provide survival benefits to elderly patients with stage II colon cancer
    Kil-yong Lee, Ji Won Park, Ki-young Lee, Sangsik Cho, Yoon-Hye Kwon, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park
    Scientific Reports.2019;[Epub]     CrossRef
  • The use of chemotherapy in older patients with stage II and III colon cancer: Variation by age and era of diagnosis
    Susan L. Green, David E. Dawe, Zoann Nugent, Winson Y. Cheung, Piotr M. Czaykowski
    Journal of Geriatric Oncology.2018;[Epub]     CrossRef
  • 8,904 View
  • 289 Download
  • 15 Web of Science
  • 17 Crossref
Close layer
Intercalated Treatment Following Rebiopsy Is Associated with a Shorter Progression-Free Survival of Osimertinib Treatment
Jeng-Sen Tseng, Tsung-Ying Yang, Kun-Chieh Chen, Kuo-Hsuan Hsu, Yen-Hsiang Huang, Kang-Yi Su, Sung-Liang Yu, Gee-Chen Chang
Cancer Res Treat. 2018;50(4):1164-1174.   Published online December 11, 2017
DOI: https://doi.org/10.4143/crt.2017.460
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Epidermal growth factor receptor (EGFR) T790M mutation serves as an important predictor of osimertinib efficacy. However, little is known about how it works among patients with various timings of T790M emergence and treatment.
Materials and Methods
Advanced EGFR-mutant lung adenocarcinoma patients with positive T790M mutation in tumor were retrospectively enrolled and observed to determine the outcomes of osimertinib treatment. We evaluated the association between patients’ characteristics and the efficacy of osimertinib treatment, particularly with respect to the timing of T790M emergence and osimertinib prescription.
Results
A total of 91 patients were enrolled, including 14 (15.4%) with primary and 77 (84.6%) with acquired T790M mutation. The objective response rate and disease controlratewere 60.9% and 85.1%, respectively. The median progression-free survival (PFS) and overall survival were 11.5 months (95% confidence interval [CI], 9.0 to 14.0) and 30.4 months (95% CI, 11.3 to 49.5), respectively. There was no significant difference in response rate and PFS between primary and acquired T790M populations. In the acquired T790M subgroup, patientswho received osimertinib after T790M had been confirmed by rebiopsy had a longer PFS than those with intercalated treatments between rebiopsy and osimertinib prescription (14.0 months [95% CI, 9.0 to 18.9] vs. 7.2 months [95% CI, 3.7 to 10.8]; adjusted hazard ratio, 0.48 [95% CI, 0.24 to 0.98; p=0.043]). Rebiopsy timing did not influence the outcome.
Conclusion
Osimertinib prescription with intercalated treatment following rebiopsy but not the timing of T790M emergence influenced the treatment outcome. We suggest that it is better to start osimertinib treatment once T790M mutation has been confirmed by biopsy.

Citations

Citations to this article as recorded by  
  • Real-world osimertinib pretreatment experience in patients with epidermal growth factor receptor T790M mutation-positive locally advanced or metastatic non-small cell lung cancer
    Gee-Chen Chang, Jin-Yuan Shih, Chong-Jen Yu, Heng-Sheng Chao, Cheng-Ta Yang, Chien-Chung Lin, Jen-Yu Hung, Sheng-Yen Hsiao, Chin-Chou Wang, Chih-Feng Chian, Te-Chun Hsia, Yuh-Min Chen, Chien-Feng Li
    PLOS ONE.2024; 19(5): e0303046.     CrossRef
  • Primary Tumor Resection Is Associated with a Better Outcome among Advanced EGFR-Mutant Lung Adenocarcinoma Patients Receiving EGFR-TKI Treatment
    Jeng-Sen Tseng, Kuo-Hsuan Hsu, Zhe-Rong Zheng, Tsung-Ying Yang, Kun-Chieh Chen, Yen-Hsiang Huang, Kang-Yi Su, Sung-Liang Yu, Gee-Chen Chang
    Oncology.2021; 99(1): 32.     CrossRef
  • Post-Progression Survival in Secondary EGFR T790M-Mutated Non-Small-Cell Lung Cancer Patients With and Without Osimertinib After Failure of a Previous EGFR TKI
    Chi-Lu Chiang, Hsu-Ching Huang, Chia-I Shen, Yung-Hung Luo, Yuh-Min Chen, Chao-Hua Chiu
    Targeted Oncology.2020; 15(4): 503.     CrossRef
  • Prior EGFR-TKI Treatment in EGFR-Mutated NSCLC Affects the Allele Frequency Fraction of Acquired T790M and the Subsequent Efficacy of Osimertinib
    Chih-Hsi Scott Kuo, Chi-Hsien Huang, Chien-Ying Liu, Stelios Pavlidis, Ho-Wen Ko, Fu-Tsai Chung, Tin-Yu Lin, Chih-Liang Wang, Yi-Ke Guo, Cheng-Ta Yang
    Targeted Oncology.2019; 14(4): 433.     CrossRef
  • 9,422 View
  • 268 Download
  • 6 Web of Science
  • 4 Crossref
Close layer
Prognosis of Pancreatic Cancer Patients with Synchronous or Metachronous Malignancies from Other Organs Is Better than Those with Pancreatic Cancer Only
Su-Jin Shin, Hosub Park, You-Na Sung, Changhoon Yoo, Dae Wook Hwang, Jin-hong Park, Kyu-pyo Kim, Sang Soo Lee, Baek-Yeol Ryoo, Dong-Wan Seo, Song Cheol Kim, Seung-Mo Hong
Cancer Res Treat. 2018;50(4):1175-1185.   Published online December 20, 2017
DOI: https://doi.org/10.4143/crt.2017.494
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Pancreatic cancer associated double primary tumors are rare and their clinicopathologic characteristics are not well elucidated.
Materials and Methods
Clinicopathologic factors of 1,352 primary pancreatic cancers with or without associated double primary tumors were evaluated.
Results
Of resected primary pancreatic cancers, 113 (8.4%) had associated double primary tumors, including 26 stomach, 25 colorectal, 18 lung, and 13 thyroid cancers. The median interval between the diagnoses of pancreatic cancer and associated double primary tumors was 0.5 months. Overall survival (OS) of pancreatic cancer patients with associated double primary tumors was longer than those with pancreatic cancer only (median, 23.1 months vs. 17.0 months, p=0.002). Patients whose pancreatic cancers were resected before the diagnosis of metachronous tumors had a better OS than patients whose pancreatic cancer resected after the diagnosis of metachronous tumors (48.9 months and 13.5 months, p=0.001) or those whose pancreatic cancers were resected synchronously with non-pancreas tumors (19.1 months, p=0.043). The OS of pancreatic cancer patients with stomach (33.9 months, p=0.032) and thyroid (117.8 months, p=0.049) cancers was significantly better than those with pancreas cancer only (17.0 months).
Conclusion
About 8% of resected pancreatic cancers had associated double primary tumors, and those from the colorectum, stomach, lung, and thyroid were common. Patients whose pancreatic cancer was resected before the diagnosis of metachronous tumors had better OS than those resected after the diagnosis of metachronous tumors or those resected synchronously.

Citations

Citations to this article as recorded by  
  • Laparoscopic Radical Total Gastrectomy and Pancreatosplenectomy for Synchronous Cancer of the Stomach and Pancreas
    Motoki Ebihara, Kentoku Fujisawa, Shusuke Haruta, Hironori Uruga, Masaki Ueno
    Cureus.2024;[Epub]     CrossRef
  • Synchronous primary multiple cancer: distal cholangiocarcinoma of the intrapancreatic common bile duct and intraductal papillary mucinous tumor associated with ductal adenocarcinoma of the pancreatic tail
    G.R. Setdikova, E.A. Stepanova, A.N. Verbovsky, A.V. Semenkov
    Pirogov Russian Journal of Surgery.2024; (8): 57.     CrossRef
  • Pancreatoduodenectomy after Ivor-Lewis Santi oesophagectomy with gastric tube reconstruction. An European multicentre experience
    Alessandro D. Mazzotta, Pietro Addeo, Benedetto Ielpo, Michael Ginesini, Nicolas Regenet, Ugo Boggi, Philippe Bachellier, Olivier Soubrane
    Surgical Oncology.2024; 57: 102144.     CrossRef
  • The importance of hsa-miR-28 in human malignancies
    Seyede Fatemeh Hosseini, Setareh Javanshir-giv, Hanieh Soleimani, Homa Mollaei, Farzad Sadri, Zohreh Rezaei
    Biomedicine & Pharmacotherapy.2023; 161: 114453.     CrossRef
  • Synchronous double primary malignancies of the pancreatic body and extrahepatic bile duct treated with pancreatoduodenectomy and splenic artery resection following neoadjuvant chemotherapy with gemcitabine plus nab-paclitaxel: a case report
    Takahiro Murokawa, Takehiro Okabayashi, Kenta Sui, Motoyasu Tabuchi, Jun Iwata
    Surgical Case Reports.2022;[Epub]     CrossRef
  • A Descriptive Study of the Types and Survival Patterns of Saudi Patients with Multiple Primary Solid Malignancies: A 30-Year Tertiary Care Center Experience
    Moustafa S. Alhamadh, Rakan B. Alanazi, Sultan T. Algarni, Ahmed Abdullah R. Alhuntushi, Mohammed Qasim Alshehri, Yusra Sajid Chachar, Mohammad Alkaiyat, Fouad Sabatin
    Current Oncology.2022; 29(7): 4941.     CrossRef
  • Synchronous Pancreatic Ductal Adenocarcinoma in the Head and Tail, a Double Trouble: A Case Report and Literature Review
    Daniel Paramythiotis, Georgia Fotiadou, Eleni Karlafti, Ioanna Abba Deka, Georgios Petrakis, Elisavet Psoma, Xanthippi Mavropoulou, Filippos Kyriakidis, Smaro Netta, Stylianos Apostolidis
    Diagnostics.2022; 12(11): 2709.     CrossRef
  • Ergebnisse nach Pankreaseingriffen aus Sicht der Betroffenen: Versorgungsforschung der Selbsthilfegruppe „Arbeitskreis der Pankreatektomierten e. V.“
    Ioannis Dimopoulos, Gabriele Meyer, Saleem Ibrahim Elhabash, Michele Sorleto, Carsten Gartung, Nils Ewald, Ulrich Klaus Fetzner, Lutz Otto, Friedhelm Möhlenbrock, Waldemar Uhl, Berthold Gerdes
    Zeitschrift für Gastroenterologie.2021; 59(03): 214.     CrossRef
  • An extremely atypical presentation of esophageal squamous cell carcinoma with pancreatic and hepatic metastases
    Lei Zhang, Xin Long, Zheng-Nan Hu, Yu Wu, Jia Song, Bi-Xiang Zhang, Wei-Xun Chen
    Medicine.2021; 100(20): e25785.     CrossRef
  • Clinical features of patients with pancreatic ductal adenocarcinoma with a history of other primary malignancies: A retrospective analysis
    Hironori Hayashi, Koji Amaya, Tomokazu Tokoro, Kosuke Mori, Shunsuke Takenaka, Yuya Sugimoto, Yuto Kitano, Toru Kurata, Shunsuke Kawai, Atsushi Hirose, Tomoya Tsukada, Masahide Kaji, Koichi Shimizu, Kiichi Maeda
    Molecular and Clinical Oncology.2021;[Epub]     CrossRef
  • A Rare Case of Synchronous Esophageal and Pancreatic Malignancy
    Ali Khalifa, Arkady Broder
    Cureus.2021;[Epub]     CrossRef
  • Synchronous concomitant pancreatic acinar cell carcin and gastric adenocarcinoma: A case report and review of literature
    Tian Fang, Ting-Ting Liang, Yi-Zhuo Wang, Hai-Tao Wu, Shu-Han Liu, Chang Wang
    World Journal of Clinical Cases.2021; 9(28): 8509.     CrossRef
  • A novel long non‑coding RNA TTN‑AS1/microRNA‑589‑5p/FOXP1 positive feedback loop increases the proliferation, migration and invasion of pancreatic cancer cell lines
    Jing Zhao, Fang Wu, Jun Yang
    Oncology Letters.2021;[Epub]     CrossRef
  • Multiple primary gastrointestinal tumors of gastric, pancreatic and rectal origin; a case report
    Abdullah Mohammed Aloraini, Hadeel Ayman Helmi, Nadia Abdulaziz Aljomah, Ahmad Mohmmed Zubaidi
    International Journal of Surgery Case Reports.2021; 89: 106610.     CrossRef
  • A Newly Developed Pancreatic Adenocarcinoma in a Patient with Advanced Thyroid Cancer under Long-Term Sorafenib Use
    Min Ji Kim, Han-Sang Baek, Sung Hak Lee, Dong-Jun Lim
    International Journal of Thyroidology.2021; 14(2): 175.     CrossRef
  • Long noncoding RNA LINC00514 accelerates pancreatic cancer progression by acting as a ceRNA of miR-28-5p to upregulate Rap1b expression
    Qing Han, Junhe Li, Jianping Xiong, Zhiwang Song
    Journal of Experimental & Clinical Cancer Research.2020;[Epub]     CrossRef
  • Molecular Characterization of a Long-Term Survivor Double Metastatic Non-Small Cell Lung Cancer and Pancreatic Ductal Adenocarcinoma Treated with Gefitinib in Combination with Gemcitabine Plus Nab-Paclitaxel and mFOLFOX6 as First and Second Line Therapy
    Oronzo Brunetti, Giuseppe Badalamenti, Simona De Summa, Angela Calabrese, Antonella Argentiero, Livia Fucci, Vito Longo, Domenico Galetta, Pia Maria Soccorsa Perrotti, Rosamaria Pinto, Daniela Petriella, Katia Danza, Stefania Tommasi, Francesco Leonetti,
    Cancers.2019; 11(6): 749.     CrossRef
  • 14,126 View
  • 241 Download
  • 17 Web of Science
  • 17 Crossref
Close layer
The Impact of Skin Problems on the Quality of Life in Patients Treated with Anticancer Agents: A Cross-Sectional Study
Jaewon Lee, Jin Lim, Jong Seo Park, Miso Kim, Tae-Yong Kim, Tae Min Kim, Kyung-Hun Lee, Bhumsuk Keam, Sae-Won Han, Je-Ho Mun, Kwang Hyun Cho, Seong Jin Jo
Cancer Res Treat. 2018;50(4):1186-1193.   Published online December 14, 2017
DOI: https://doi.org/10.4143/crt.2017.435
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Patients treated with anticancer agents often experience a variety of treatment-related skin problems, which can impair their quality of life.
Materials and Methods
In this cross-sectional study, Dermatology Life Quality Index (DLQI) and clinical information were evaluated in patients under active anticancer treatment using a questionnaire survey and their medical records review.
Results
Of 375 evaluated subjects with anticancer therapy, 136 (36.27%) and 114 (30.40%) were treated for breast cancer and colorectal cancer, respectively. We found that women, breast cancer, targeted agent use, and longer duration of anticancer therapy were associated with higher dermatology-specific quality of life distraction. In addition, itching, dry skin, easy bruising, pigmentation, papulopustules on face, periungual inflammation, nail changes, and palmoplantar lesions were associated with significantly higher DLQI scores. Periungual inflammation and palmoplantar lesions scored the highest DLQI.
Conclusion
We believe our findings can be helpful to clinicians in counseling and managing the patients undergoing anticancer therapy.

Citations

Citations to this article as recorded by  
  • The Impact of Dermatologic Adverse Events on the Quality of Life of Oncology Patients: A Review of the Literature
    Annika Belzer, Jolanta J. Pach, Kailyn Valido, Jonathan S. Leventhal
    American Journal of Clinical Dermatology.2024; 25(3): 435.     CrossRef
  • Quality of Life Impact in Patients with Cutaneous Toxicities Caused by Epidermal Growth Factor Receptor Inhibitors and Immunotherapy
    Maria Mannino, Pietro Sollena, Alessandro Di Stefani, Ernesto Rossi, Ettore D’Argento, Giovanni Schinzari, Giampaolo Tortora, Ketty Peris
    Dermatology.2024; 240(4): 523.     CrossRef
  • A comprehensive study of adverse effects of chemotherapy on female breast cancer patients in NORI Cancer Hospital, Islamabad in a developing country
    Areesha Abid, Humza Saeed, Uswa Iftikhar, Muhammad Khubaib Arshad, Muhammad Uzair Shahid, Tayyab Rasool, Faizan Fazal, Aman Goyal, Anum Akbar
    Journal of Oncology Pharmacy Practice.2024;[Epub]     CrossRef
  • Chemotherapy induced alopecia in breast cancer patients: A monocentric prospective study
    Wala Ben Kridis, Olfa Boudawara, Afef Khanfir
    Breast Disease.2024; 43(1): 251.     CrossRef
  • Impact of Xerosis in Patients With Cancer Receiving Epidermal Growth Factor Receptor or Mitogen-Activated Protein Kinase Inhibitors: ATIXI, A Non-Interventional, Prospective, Pilot Study
    Pietro Quaglino, Giuseppe Argenziano, Emi Dika, Michela Starace, Simone Amabile, Paolo Fava, Elvira Moscarella, Bianca Maria Piraccini, Alain Delarue, Olivia Dialla, Fabienne Zumaglini, Giampiero Girolomoni
    Dermatology Practical & Conceptual.2024; 14(4): e2024259.     CrossRef
  • Global trends in adolescent and young adult female cancer burden, 1990-2021: insights from the Global Burden of Disease study
    Z. Huang, J. Wang, H. Liu, B. Wang, M. Qi, Z. Lyu, H. Liu
    ESMO Open.2024; 9(11): 103958.     CrossRef
  • Dermatologic toxicities of chemotherapy: an educational intervention for skin of color women with breast cancer
    Maham Ahmad, Sabrina Saeed, Brianna Olamiju, Andrea Silber, Jonathan Leventhal
    International Journal of Women’s Dermatology.2023; 9(1): e073.     CrossRef
  • Aloe vera gel for prevention of chemotherapy-induced hyperpigmentation: Four case reports
    Chia-Chi Chiu, Yi-Wen Hsiao, Yu-Chuan Wen, Tsung-Yen Chang, Shih-Hsiang Chen, Tang-Her Jaing
    Medicine.2023; 102(25): e34037.     CrossRef
  • Skin-related Quality of Life in Patients with Lung Cancer Taking Oral Targeted Agents: A Single-Center, Cross-Sectional Study
    Joo Mi Park, Jeong Hye Kim
    Asian Oncology Nursing.2023; 23(2): 84.     CrossRef
  • Dermatological Side Effects of Cancer Treatment: Psychosocial Implications—A Systematic Review of the Literature
    Vera Almeida, Daniela Pires, Marta Silva, Maribel Teixeira, Ricardo João Teixeira, André Louro, Maria Alzira Pimenta Dinis, Maria Ferreira, Ana Teixeira
    Healthcare.2023; 11(19): 2621.     CrossRef
  • The role of dermocosmetics in the management of cancer-related skin toxicities: international expert consensus
    Brigitte Dreno, Kiarash Khosrotehrani, Giselle De Barros Silva, Julie Ryan Wolf, Delphine Kerob, Mark Trombetta, Etienne Atenguena, Pascale Dielenseger, Meng Pan, Florian Scotte, Ivan Krakowski, Mario Lacouture
    Supportive Care in Cancer.2023;[Epub]     CrossRef
  • Effectiveness and Tolerability of Natural Herbal Formulations in the Prevention of Radiation-Induced Skin Toxicity in Patients Undergoing Radiotherapy
    Georgios Koukourakis, Georgios Pissakas, Christos G. Ganos, Gregory Sivolapenko, Dimitrios Kardamakis
    The International Journal of Lower Extremity Wounds.2022; 21(1): 75.     CrossRef
  • Effects of the epidermal growth factor receptor inhibitor, gefitinib, on lipid and hyaluronic acid synthesis in cultured HaCaT keratinocytes
    Jang‐Hee Oh, Woojune Hur, Na Li, Seong Jin Jo
    Experimental Dermatology.2022; 31(6): 918.     CrossRef
  • An Emollient PLUS Balm Is Useful for the Management of Xerosis in Patients Treated for Cancer: A Real-World, Prospective, Observational, Multicenter Study
    Véronique Vendrely, Ander Mayor-Ibarguren, Aline Stennevin, Ariadna Ortiz-Brugués
    Dermatology and Therapy.2022; 12(3): 683.     CrossRef
  • Nail pigmentation induced by chemotherapy: an observational study of patients with early-stage breast cancer
    Kuikui Jiang, Simei Shi, Qiulian Lin, Peng Sun, Luan Zhang, Zhongyu Yuan, Ruoxi Hong, Yanxia Shi, Xia Liu, Jingmin Zhang, Jiajia Huang, Xiwen Bi, Wen Xia, Qianyi Lu, Qiufan Zheng, Shusen Wang, Fei Xu
    Holistic Integrative Oncology.2022;[Epub]     CrossRef
  • Cutaneous adverse events in patients receiving anticancer therapy in a tertiary hospital setting: the old and the new
    Hae‐Jin Suh, Ángeles Flórez, Víctor Sacristán, Ángeles Rodríguez Martinez, Francisca Fernández, Lucía Vilanova‐Trillo, Manuel Constenla, Manuel Pereiro
    International Journal of Dermatology.2021; 60(2): 208.     CrossRef
  • The Impact of Acne, Atopic Dermatitis, Skin Toxicities and Scars on Quality of Life and the Importance of a Holistic Treatment Approach
    Brigitte Dreno, Jean Michel Amici, Ann Laure Demessant-Flavigny, Charlotte Wright, Charles Taieb, Seemal R Desai, Andrew Alexis
    Clinical, Cosmetic and Investigational Dermatology.2021; Volume 14: 623.     CrossRef
  • Evaluating health related quality of life in outpatients receiving anti-cancer treatment: results from an observational, cross-sectional study
    Hae-Jin Suh Oh, Ángeles Flórez Menéndez, Víctor Sacristán Santos, Ángeles Rodríguez Martínez, Francisca Fernández Ribeiro, Lucía Vilanova-Trillo, Manuel Constenla Figueiras, Manuel Pereiro Ferreiros
    Health and Quality of Life Outcomes.2021;[Epub]     CrossRef
  • Dermatologic conditions in women receiving systemic cancer therapy
    Michelle N. Ferreira, Julie Y. Ramseier, Jonathan S. Leventhal
    International Journal of Women's Dermatology.2019; 5(5): 285.     CrossRef
  • 8,344 View
  • 213 Download
  • 20 Web of Science
  • 19 Crossref
Close layer
Lifestyle Risk Prediction Model for Prostate Cancer in a Korean Population
Sung Han Kim, Sohee Kim, Jae Young Joung, Whi-An Kwon, Ho Kyung Seo, Jinsoo Chung, Byung-Ho Nam, Kang Hyun Lee
Cancer Res Treat. 2018;50(4):1194-1202.   Published online December 21, 2017
DOI: https://doi.org/10.4143/crt.2017.484
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The use of prostate-specific antigen as a biomarker for prostate cancer (PC) has been controversial and is, therefore, not used by many countries in their national health screening programs. The biological characteristics of PC in East Asians including Koreans and Japanese are different from those in the Western populations. Potential lifestyle risk factors for PC were evaluated with the aim of developing a risk prediction model.
Materials and Methods
A total of 1,179,172 Korean men who were cancer free from 1996 to 1997, had taken a physical examination, and completed a lifestyle questionnaire, were enrolled in our study to predict their risk for PC for the next eight years, using the Cox proportional hazards model. The model’s performance was evaluated using the C-statistic and Hosmer‒Lemeshow type chi-square statistics.
Results
The risk prediction model studied age, height, body mass index, glucose levels, family history of cancer, the frequency of meat consumption, alcohol consumption, smoking status, and physical activity, which were all significant risk factors in a univariate analysis. The model performed very well (C statistic, 0.887; 95% confidence interval, 0.879 to 0.895) and estimated an elevated PC risk in patients who did not consume alcohol or smoke, compared to heavy alcohol consumers (hazard ratio [HR], 0.78) and current smokers (HR, 0.73) (p < 0.001).
Conclusion
This model can be used for identifying Korean and other East Asian men who are at a high risk for developing PC, as well as for cancer screening and developing preventive health strategies.

Citations

Citations to this article as recorded by  
  • To Drink or Not to Drink? Investigating Alcohol’s Impact on Prostate Cancer Risk
    Aris Kaltsas, Michael Chrisofos, Evangelos N. Symeonidis, Athanasios Zachariou, Marios Stavropoulos, Zisis Kratiras, Ilias Giannakodimos, Asterios Symeonidis, Fotios Dimitriadis, Nikolaos Sofikitis
    Cancers.2024; 16(20): 3453.     CrossRef
  • Combinations of lifestyle behaviors and cancer risk among Korean adults
    Ngoc Minh Luu, Thi Tra Bui, Thi Phuong Thao Tran, Thi Huyen Trang Nguyen, Jin-Kyoung Oh
    Scientific Reports.2023;[Epub]     CrossRef
  • Cigarette smoking and prostate cancer: A systematic review and meta-analysis of prospective cohort studies
    Sarah Al-Fayez, Ashraf El-Metwally
    Tobacco Induced Diseases.2023; 21(February): 1.     CrossRef
  • Prostate cancer risk prediction based on clinical factors and prostate-specific antigen
    Taewon Hwang, Hyungseok Oh, Jung Ah Lee, Eo Jin Kim
    BMC Urology.2023;[Epub]     CrossRef
  • Association Between Red and Processed Meat Consumption and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis
    Saeedeh Nouri-Majd, Asma Salari-Moghaddam, Azadeh Aminianfar, Bagher Larijani, Ahmad Esmaillzadeh
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Alcohol and Prostate Cancer: Time to Draw Conclusions
    Amanda J. Macke, Armen Petrosyan
    Biomolecules.2022; 12(3): 375.     CrossRef
  • Diagnostic accuracy of prostate-specific antigen below 4 ng/mL as a cutoff for diagnosing prostate cancer in a hospital setting: A systematic review and meta-analysis
    Yan Jin, Jae Hung Jung, Woong Kyu Han, Eu Chang Hwang, Yoonmi Nho, Narae Lee, Ji Eun Yun, Kwang Suk Lee, Sang Hyub Lee, Hakmin Lee, Su-Yeon Yu
    Investigative and Clinical Urology.2022; 63(3): 251.     CrossRef
  • Association between Relative Preference for Vegetables and Meat and Cancer Incidence in Korean Adults: A Nationwide Population-based Retrospective Cohort Study
    Ga-Eun Yie, An Na Kim, Hyun Jeong Cho, Minji Kang, Sungji Moon, Inah Kim, Kwang-Pil Ko, Jung Eun Lee, Sue K. Park
    Korean Journal of Community Nutrition.2021; 26(3): 211.     CrossRef
  • Prostate Cancer Risk Calculators for Healthy Populations: Systematic Review
    Antonio Bandala-Jacques, Kevin Daniel Castellanos Esquivel, Fernanda Pérez-Hurtado, Cristobal Hernández-Silva, Nancy Reynoso-Noverón
    JMIR Cancer.2021; 7(3): e30430.     CrossRef
  • Personalized 5-Year Prostate Cancer Risk Prediction Model in Korea Based on Nationwide Representative Data
    Yohwan Yeo, Dong Wook Shin, Jungkwon Lee, Kyungdo Han, Sang Hyun Park, Keun Hye Jeon, Jungeun Shin, Aesun Shin, Jinsung Park
    Journal of Personalized Medicine.2021; 12(1): 2.     CrossRef
  • Lifestyles, health habits, and prostate cancer
    Tomoyuki Kawada
    Journal of Cancer Research and Clinical Oncology.2020; 146(6): 1623.     CrossRef
  • Combination possibility and deep learning model as clinical decision-aided approach for prostate cancer
    Okyaz Eminaga, Omran Al-Hamad, Martin Boegemann, Bernhard Breil, Axel Semjonow
    Health Informatics Journal.2020; 26(2): 945.     CrossRef
  • Tailored Biofunctionalized Biosensor for the Label-Free Sensing of Prostate-Specific Antigen
    Sachin Mishra, Eun-Seong Kim, Parshant Kumar Sharma, Zhi-Ji Wang, Sung-Hyun Yang, Ajeet Kumar Kaushik, Cong Wang, Yang Li, Nam-Young Kim
    ACS Applied Bio Materials.2020; 3(11): 7821.     CrossRef
  • A Study on Risk Factors of the Incidence of Prostate Cancer Using National Health Insurance Service: Effects of BMI on Age
    Hye Sim Kim, Tae Hwa Go, Dae Ryong Kang, Jae Hung Jung, Sung Won Kwon, Sae Chul Kim, Jae Mann Song, Hyun Chul Chung, Sang Baek Koh
    Journal of Health Informatics and Statistics.2019; 44(4): 410.     CrossRef
  • 10,000 View
  • 256 Download
  • 12 Web of Science
  • 14 Crossref
Close layer
CCR6 Is a Predicting Biomarker of Radiosensitivity and Potential Target of Radiosensitization in Rectal Cancer
Hui Chang, Jia-wang Wei, Ya-lan Tao, Pei-rong Ding, Yun-fei Xia, Yuan-hong Gao, Wei-wei Xiao
Cancer Res Treat. 2018;50(4):1203-1213.   Published online December 21, 2017
DOI: https://doi.org/10.4143/crt.2017.538
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
This study aimed to explore the functions and mechanisms of C-C motif chemokine receptor 6 (CCR6), a gene associated with progression and metastasis of colorectal cancer (CRC), in radiosensitivity of rectal cancer (RC).
Materials and Methods
RNA sequencing and immunohistochemical analysis on CCR6 expression were performed in pretreatment tissues of RC patients exhibiting different therapeutic effects of radiotherapy. Colonogenic survival assay was conducted in different CRC cell lines to assess their radiosensitivity. And the impact of CCR6 expression on radiosensitivity was validated through RNA interference. The DNA damage repair (DDR) abilities of cell lines with different CCR6 expression were evaluated through immunofluorescence-based γH2AX quantification.
Results
The CCR6 mRNA level was higher in patients without pathologic complete remission (pCR) than in those with pCR (fold changed, 2.11; p=0.004). High-level expression of CCR6 protein was more common in the bad responders than in the good responders (76.3% vs. 37.5%, p < 0.001). The CRC cell lines with higher CCR6 expression (LoVo and sw480) appeared to be more radioresistant, compared with the sw620 cell line which had lower CCR6 expression. CCR6 knockdown made the LoVo cells more sensitive to ionizing radiation (sensitization enhancement ratio, 1.738; p < 0.001), and decreased their DDR efficiency.
Conclusion
CCR6 might affect the RC radiosensitivity through DDR process. These findings supported CCR6 as a predicting biomarker of radiosensitivity and a potential target of radiosensitization for RC patients.

Citations

Citations to this article as recorded by  
  • Mechanisms of radioresistance and the underlying signaling pathways in colorectal cancer cells
    Josiane W. Tessmann, Murilo R. Rocha, Jose A. Morgado‐Díaz
    Journal of Cellular Biochemistry.2023; 124(1): 31.     CrossRef
  • Nuclear Factor Erythroid 2-Related Factor 2/Kelch-Like ECH-Associated Protein 1 as a Predictor of Prognosis and Radiotherapy Resistance in Patients With Locally Advanced Rectal Cancer: A Prospective Analysis
    Ji Min Park, Shin Kim, Sung Uk Bae, Sang Jun Byun, Incheol Seo, Hye Won Lee
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Radiotherapy resistance: identifying universal biomarkers for various human cancers
    Irina Larionova, Militsa Rakina, Elena Ivanyuk, Yulia Trushchuk, Alena Chernyshova, Evgeny Denisov
    Journal of Cancer Research and Clinical Oncology.2022; 148(5): 1015.     CrossRef
  • Predicting response to neoadjuvant chemoradiotherapy in rectal cancer: from biomarkers to tumor models
    Moying Li, Qiyun Xiao, Nachiyappan Venkatachalam, Ralf-Dieter Hofheinz, Marlon R. Veldwijk, Carsten Herskind, Matthias P. Ebert, Tianzuo Zhan
    Therapeutic Advances in Medical Oncology.2022;[Epub]     CrossRef
  • 131I-C19 Iodide Radioisotope and Synthetic I-C19 Compounds as K-Ras4B–PDE6δ Inhibitors: A Novel Approach against Colorectal Cancer—Biological Characterization, Biokinetics and Dosimetry
    Pedro Cruz-Nova, Blanca Ocampo-García, Dayan Andrea Carrión-Estrada, Paola Briseño-Diaz, Guillermina Ferro-Flores, Nallely Jiménez-Mancilla, José Correa-Basurto, Martiniano Bello, Libia Vega-Loyo, María del Rocío Thompson-Bonilla, Rosaura Hernández-Rivas,
    Molecules.2022; 27(17): 5446.     CrossRef
  • Regulation of pancreatic cancer therapy resistance by chemokines
    Shailendra K. Gautam, Soumi Basu, Abhijit Aithal, Nidhi V. Dwivedi, Mansi Gulati, Maneesh Jain
    Seminars in Cancer Biology.2022; 86: 69.     CrossRef
  • Biomarkers for Predicting the Response to Radiation-Based Neoadjuvant Therapy in Rectal Cancer
    Yuhong Chen, Biao Yang, Mingyang Chen, Zhaojun Li, Zhengyin Liao
    Frontiers in Bioscience-Landmark.2022;[Epub]     CrossRef
  • Cancer Stem Cell Biomarkers Predictive of Radiotherapy Response in Rectal Cancer: A Systematic Review
    Marzia Mare, Lorenzo Colarossi, Veronica Veschi, Alice Turdo, Dario Giuffrida, Lorenzo Memeo, Giorgio Stassi, Cristina Colarossi
    Genes.2021; 12(10): 1502.     CrossRef
  • ceRNA Networks: The Backbone Role in Neoadjuvant Chemoradiotherapy Resistance/Sensitivity of Locally Advanced Rectal Cancer
    Lin He, Hao Chang, Yuhong Qi, Bing Zhang, Qiuju Shao
    Technology in Cancer Research & Treatment.2021;[Epub]     CrossRef
  • Antitumor and Anti-Metastatic Effects of Citral-Loaded Nanostructured Lipid Carrier in 4T1-Induced Breast Cancer Mouse Model
    Noraini Nordin, Swee Keong Yeap, Heshu Sulaiman Rahman, Nur Rizi Zamberi, Nurul Elyani Mohamad, Nadiah Abu, Mas Jaffri Masarudin, Rasedee Abdullah, Noorjahan Banu Alitheen
    Molecules.2020; 25(11): 2670.     CrossRef
  • Andrographolide enhanced radiosensitivity by downregulating glycolysis via the inhibition of the PI3K-Akt-mTOR signaling pathway in HCT116 colorectal cancer cells
    Xiaofei Li, Ruifang Tian, Lan Liu, Lihui Wang, Dong He, Ke Cao, John K. Ma, Chenghui Huang
    Journal of International Medical Research.2020;[Epub]     CrossRef
  • Exploring the radiosensitizing potential of AZD8931: a pilot study on the human LoVo colorectal cancer cell line
    Cinzia Antognelli, Isabella Palumbo, Simonetta Piattoni, Monica Calzuola, Beatrice Del Papa, Vincenzo N. Talesa, Cynthia Aristei
    International Journal of Radiation Biology.2020; 96(11): 1504.     CrossRef
  • The expression of long noncoding RNA CRCAL‐3 in colorectal cancer and its impacts on cell proliferation and migration
    Hui Chang, Guan‐Nan Wang, Ya‐Lan Tao
    Journal of Cellular Biochemistry.2019; 120(9): 15369.     CrossRef
  • Pleiotropic Immune Functions of Chemokine Receptor 6 in Health and Disease
    Ranmali Ranasinghe, Rajaraman Eri
    Medicines.2018; 5(3): 69.     CrossRef
  • Autophagy-regulating microRNAs: potential targets for improving radiotherapy
    Hongbin Li, Xiaodong Jin, Bing Chen, Ping Li, Qiang Li
    Journal of Cancer Research and Clinical Oncology.2018; 144(9): 1623.     CrossRef
  • 9,876 View
  • 220 Download
  • 15 Web of Science
  • 15 Crossref
Close layer
Survival and Functional Outcome after Treatment for Primary Base of Tongue Cancer: A Comparison of Definitive Chemoradiotherapy versus Surgery Followed by Adjuvant Radiotherapy
Sangjoon Park, Yeona Cho, Jeongshim Lee, Yoon Woo Koh, Se-Heon Kim, Eun Chang Choi, Hye Ryun Kim, Ki Chang Keum, Kyung Ran Park, Chang Geol Lee
Cancer Res Treat. 2018;50(4):1214-1225.   Published online December 26, 2017
DOI: https://doi.org/10.4143/crt.2017.498
AbstractAbstract PDFPubReaderePub
Purpose
The purpose of this study was to compare the clinical and functional outcomes in patients with primary base of tongue (BOT) cancer who received definitive radiotherapy (RT) or surgery followed by radiotherapy (SRT).
Materials and Methods
Between January 2002 andDecember 2016, 102 patientswith stage I-IVB primary BOT cancer underwent either definitive RT (n=46) or SRT (n=56), and treatment outcomeswere compared between two groups. The expression of p16 was also analyzed.
Results
The RT group had more patients with advanced T stage (T3-4) disease (58.7% vs. 35.7%, p=0.021) and who received chemotherapy (91.3% vs. 37.5%, p < 0.001) than the SRT group. At a median followup of 36.9 months (range, 3.3 to 181.5 months), the 5-year overall survival (OS) and disease-free survival (DFS) were 75.5% and 68.7%, respectively. With respect to treatment group, the 5-year OS and DFS in the RT and SRT groups did not differ significantly (OS, 68.7% vs. 80.5%, p=0.601; DFS, 63.1% vs. 73.1%, p=0.653). In multivariate analysis, OS differed significantly according to p16 expression (p16-negative vs. p16- positive; hazard ratio [HR], 0.145; 95% confidence interval [CI], 0.025 to 0.853; p=0.033). Regarding DFS, p16 expression (p16-negative vs. p16-positive; HR, 0.164; 95% CI, 0.045 to 0.598; p=0.006) showed a significant effect in multivariate analysis. Functional defects (late grade ≥ 3 dysphagia or voice alteration) were more frequently reported in the SRT than in the RT group (16.1% vs. 2.2%, p=0.021).
Conclusion
Despite advanced disease, patients in the RT group showed comparable survival outcomes and better functional preservation than those in the SRT group.

Citations

Citations to this article as recorded by  
  • Treatment de‐escalation for HPV+ oropharyngeal cancer: A systematic review and meta‐analysis
    Fausto Petrelli, Andrea Luciani, Antonio Ghidini, Sara Cherri, Paolo Gamba, Marta Maddalo, Paolo Bossi, Alberto Zaniboni
    Head & Neck.2022; 44(5): 1255.     CrossRef
  • Ginsenoside Rd inhibits migration and invasion of tongue cancer cells through H19/miR-675-5p/CDH1 axis
    Lu CHANG, Dongxu WANG, Shaoning KAN, Ming HAO, Huimin LIU, Zhijing YANG, Qianyun XIA, Weiwei LIU
    Journal of Applied Oral Science.2022;[Epub]     CrossRef
  • Postoperative Concurrent Chemoradiotherapy Versus Radiotherapy Alone for Advanced Oral Cavity Cancer in the Era of Modern Radiation Techniques
    Tae Hyung Kim, In-Ho Cha, Eun Chang Choi, Hye Ryun Kim, Hyung Jun Kim, Se-Heon Kim, Ki Chang Keum, Chang Geol Lee
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Superficial circumflex iliac artery perforator flap for tongue reconstruction after hemiglossectomy for cancer: A case report
    Hong Loi Nguyen, Truong Phu M. Ho, Xuan Phu Tran, Thanh Xuan Nguyen
    Oral and Maxillofacial Surgery Cases.2021; 7(2): 100219.     CrossRef
  • Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy
    Ambika Parmar, Michaelina Macluskey, Niall Mc Goldrick, David I Conway, Anne-Marie Glenny, Janet E Clarkson, Helen V Worthington, Kelvin KW Chan
    Cochrane Database of Systematic Reviews.2021;[Epub]     CrossRef
  • Larynx-preserving reconstruction after extended base of the tongue resection
    Hideki Kadota, Junichi Fukushima, Sei Yoshida, Kenichi Kamizono, Muneyuki Masuda, Satoshi Toh, Ryuji Yasumatsu, Torahiko Nakashima, Takashi Nakagawa
    Journal of Plastic, Reconstructive & Aesthetic Surgery.2020; 73(4): 740.     CrossRef
  • 9,642 View
  • 228 Download
  • 6 Web of Science
  • 6 Crossref
Close layer
Safety Results and Analysis of Eribulin Efficacy according to Previous Microtubules-Inhibitors Sensitivity in the French Prospective Expanded Access Program for Heavily Pre-treated Metastatic Breast Cancer
Renaud Sabatier, Véronique Diéras, Xavier Pivot, Etienne Brain, Henri Roché, Jean-Marc Extra, Audrey Monneur, Magali Provansal, Carole Tarpin, François Bertucci, Patrice Viens, Christophe Zemmour, Anthony Gonçalves
Cancer Res Treat. 2018;50(4):1226-1237.   Published online December 28, 2017
DOI: https://doi.org/10.4143/crt.2017.446
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Eribulin is approved for advanced breast cancers refractory to anthracyclines and taxanes. Efficacy according to sensitivity to previous therapies has been poorly explored.
Materials and Methods
Safety data were collected prospectively and we retrospectively collected efficacy data from the five French centres that participated in the Eribulin E7389-G000-398 expanded access program. Our main objectiveswere exploration of safety and analysis of eribulin efficacy (progression-free survival [PFS] and overall survival [OS]) according to sensitivity to the last microtubule-inhibiting agent administered.
Results
Median eribulin treatment duration was 3.3 months for the 250 patients included in this prospective single-arm study. Two hundreds and thirty-nine patients (95.6%) experienced an adverse event (AE) related to treatment including 129 (51.6%) with grade ≥ 3 AEs. The most frequently observed toxicities were cytopenias (59.6% of included patients), gastrointestinal disorders (59.2%), and asthenia (56.4%). The most frequent grade 3-4 AE was neutropenia (37.2% with 4.8% febrile neutropenia). Median PFS and OS were 4.6 and 11.8 months, respectively. Patients classified as responders to the last microtubule-inhibiting therapy had a longer OS (hazard ratio [HR], 0.69; 95% confidence interval [CI], 0.51 to 0.94; p=0.017), and tended to display a better PFS (HR, 0.78; 95% CI, 0.58 to 1.04; p=0.086). OS improvement was still significant in multivariate analysis (adjusted HR, 0.53; 95% CI, 0.35 to 0.79; p=0.002).
Conclusion
This work based on a prospective study suggests that identification of patients likely to be more sensitive to eribulin could be based on their previous response to microtubules inhibitors.

Citations

Citations to this article as recorded by  
  • Emerging treatment approaches for triple-negative breast cancer
    Maurizio Capuozzo, Venere Celotto, Mariachiara Santorsola, Antonio Fabozzi, Loris Landi, Francesco Ferrara, Assunta Borzacchiello, Vincenza Granata, Francesco Sabbatino, Giovanni Savarese, Marco Cascella, Francesco Perri, Alessandro Ottaiano
    Medical Oncology.2023;[Epub]     CrossRef
  • Breast cancer treatment-related cardiovascular disturbances: advocacy for a watchful attitude in this never-ending story
    Charlène Rivier, Benoite Mery, Elise Rowinski, Sandrine Sotton, Wafa Bouleftour, Laurent Bertoletti, Olivier Tredan, Nicolas Magne
    Expert Opinion on Drug Safety.2022; 21(4): 453.     CrossRef
  • Optimization of G-CSF dosing schedule in patients treated with eribulin: a modeling approach
    Manon Reda, Pauline Macaire, Hélène Bellio, Lionel Uwer, Silvia Ilie, Véronique Lorgis, Audrey Hennequin, Sylvain Ladoire, Emilie Rederstorff, Pierre Fumoleau, Nicolas Isambert, Nathalie Bonnin, Benoit You, Gilles Freyer, Isabelle Desmoulins, Antonin Schm
    Cancer Chemotherapy and Pharmacology.2022; 89(2): 197.     CrossRef
  • Eribulin Efficacy on Brain Metastases in Heavily Pretreated Patients with Metastatic Breast Cancer
    Renaud Sabatier, Johan Martin, Cécile Vicier, Mathilde Guérin, Audrey Monneur, Magali Provansal, Louis Tassy, Carole Tarpin, Jean-Marc Extra, Frédéric Viret, Anthony Goncalves
    Journal of Clinical Medicine.2021; 10(6): 1272.     CrossRef
  • The relative effectiveness of eribulin for advanced breast cancer treatment: a study of the southeast Netherlands advanced breast cancer registry
    X. G. L. V. Pouwels, S. M. E. Geurts, B. L. T. Ramaekers, F. Erdkamp, B. E. P. J. Vriens, K. N. A. Aaldering, A. J. van de Wouw, M. W. Dercksen, T. J. Smilde, N. A. J. B. Peters, J. M. van Riel, M. J. Pepels, J. Heijnen-Mommers, M. A. Joore, V. C. G. Tjan
    Acta Oncologica.2020; 59(1): 82.     CrossRef
  • Systematic review of Real-World effectiveness of eribulin for locally advanced or metastatic breast cancer
    Isabelle Chabot, Qi Zhao, Yun Su
    Current Medical Research and Opinion.2020; 36(12): 2025.     CrossRef
  • Real‐life activity of eribulin mesylate among metastatic breast cancer patients in the multicenter national observational ESME program
    William Jacot, Pierre‐Etienne Heudel, Julien Fraisse, Sophie Gourgou, Séverine Guiu, Florence Dalenc, Barbara Pistilli, Mario Campone, Christelle Levy, Marc Debled, Marianne Leheurteur, Marie Chaix, Claudia Lefeuvre, Anthony Goncalves, Lionel Uwer, Jean‐M
    International Journal of Cancer.2019; 145(12): 3359.     CrossRef
  • 8,027 View
  • 232 Download
  • 9 Web of Science
  • 7 Crossref
Close layer
Prognoses and Clinical Outcomes of Primary and Recurrent Uveal Melanoma
Jee Hung Kim, Su-Jin Shin, Soo Jin Heo, Eun-Ah Choe, Chang Gon Kim, Minkyu Jung, Ki Chang Keum, Jin Sook Yoon, Sung Chul Lee, Sang Joon Shin
Cancer Res Treat. 2018;50(4):1238-1251.   Published online December 28, 2017
DOI: https://doi.org/10.4143/crt.2017.534
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Uveal melanoma has a very poor prognosis despite successful local primary tumor treatment. In this study, we investigated prognostic factors that more accurately reflected the likelihood ofrecurrence and survival and delineated a prognostic model that could effectively identify different risk groups based on initial clinical parameters.
Materials and Methods
Prognostic factors associated with distant recurrence, recurrence-free survival (RFS), progression-free survival, and overall survival from distant recurrence to death (OS2) were analyzed in 226 patients with stage I-III uveal melanoma who underwent primary local therapy.
Results
Forty-nine patients (21.7%) had distant recurrences, which occurred most frequently in the liver (87.7%). In a multivariate analysis, local radiotherapy improved RFS among patients with multiple recurrence risk factors relative to excision (not reached vs. 19.0 months, p=0.004). Patients with BRCA1-associated protein-1 (BAP1)‒negative primary tumors showed a longer RFS duration after primary treatments, while those with BAP1-negative metastatic tissues had a shorter OS2 compared to those with BAP1-positive tumors, both not statistically insignificance (RFS: not reached vs. 82.0 months, p=0.258; OS2: 15.7 vs. 24.4 months, p=0.216). Male sex (hazard ratio [HR], 3.79; p=0.012), a short RFS (HR, 4.89; p=0.014), and a largest metastatic tumor linear diameter ≥ 45 mm (HR, 5.48; p=0.017) were found to correlate with worse post-recurrence survival.
Conclusion
Risk factors could be used to classify uveal melanoma cases and subsequently direct individual treatment strategies. Furthermore, metastasectomy appears to contribute to improved survival outcomes.

Citations

Citations to this article as recorded by  
  • Uveal Melanoma: Comprehensive Review of Its Pathophysiology, Diagnosis, Treatment, and Future Perspectives
    Merve Kulbay, Emily Marcotte, Raheem Remtulla, Tsz Hin Alexander Lau, Manuel Paez-Escamilla, Kevin Y. Wu, Miguel N. Burnier
    Biomedicines.2024; 12(8): 1758.     CrossRef
  • Impact of Metastatic Pattern on Survival in Patients with Posterior Uveal Melanoma: A Retrospective Cohort Study
    Tine G. Hindso, Peter S. Jensen, Mette B. Sjøl, Kristoffer Nissen, Camilla W. Bjerrum, Eric von Benzon, Carsten Faber, Steen F. Urbak, Marco Donia, Inge M. Svane, Eva Ellebaek, Steffen Heegaard, Karine Madsen, Jens F. Kiilgaard
    Cancers.2024; 16(19): 3346.     CrossRef
  • Identification of a prognostic six-immune-gene signature and a nomogram model for uveal melanoma
    Binghua Yang, Yuxia Fan, Renlong Liang, Yi Wu, Aiping Gu
    BMC Ophthalmology.2023;[Epub]     CrossRef
  • Prognostic Value of the Radiomics-Based Model in the Disease-Free Survival of Pretreatment Uveal Melanoma: An Initial Result
    Yaping Su, Xiaolin Xu, Fang Wang, Panli Zuo, Qinghua Chen, Wenbin Wei, Junfang Xian
    Journal of Computer Assisted Tomography.2023; 47(1): 151.     CrossRef
  • Uveal melanoma pathobiology: Metastasis to the liver
    Prisca Bustamante, Léo Piquet, Solange Landreville, Julia V. Burnier
    Seminars in Cancer Biology.2021; 71: 65.     CrossRef
  • Malignant uveal melanoma with metastatic recurrence to the pancreas: A case report
    Wei‐Chun Weng, Tzung‐Jiun Tsai, Wen‐Chi Chen, Jin‐Shiung Cheng, Wei‐Chih Sun
    Advances in Digestive Medicine.2021; 8(3): 178.     CrossRef
  • Role of somatic mutations and chromosomal aberrations in the prognosis of uveal melanoma in a Spanish patient cohort
    Paula Silva‐Rodríguez, Manuel Bande, Daniel Fernández‐Díaz, Nerea Lago‐Baameiro, María Pardo, María José Blanco‐Teijeiro, Fernando Domínguez, Lourdes Loidi, Antonio Piñeiro
    Acta Ophthalmologica.2021;[Epub]     CrossRef
  • Clinical features and survival outcomes of ocular melanoma in a multi-ethnic Asian cohort
    Laura Ling Ying Tan, Jiancheng Hong, Wei Lin Goh, Esther Wei Yin Chang, Valerie Shiwen Yang, Eileen Poon, Nagavalli Somasundaram, Mohamad Farid, Anita Sook Yee Chan, Jason Yongsheng Chan
    Scientific Reports.2020;[Epub]     CrossRef
  • ЕФЕКТИВНІСТЬ РАДІОХВИЛЬОВОЇ (3,8 МГЦ) БЛОКЕКСЦИЗІЇ МЕЛАНОМИ ЦИЛІОХОРІОЇДАЛЬНОЇ ЛОКАЛІЗАЦІЇ
    O. V. Khomyakova
    Здобутки клінічної і експериментальної медицини.2020; (3): 173.     CrossRef
  • 10,383 View
  • 231 Download
  • 10 Web of Science
  • 9 Crossref
Close layer
Phase II Study of Dovitinib in Patients with Castration-Resistant Prostate Cancer (KCSG-GU11-05)
Yoon Ji Choi, Hye Sook Kim, Se Hoon Park, Bong-Seog Kim, Kyoung Ha Kim, Hyo Jin Lee, Hong Suk Song, Dong-Yeop Shin, Ha Young Lee, Hoon-Gu Kim, Kyung Hee Lee, Jae Lyun Lee, Kyong Hwa Park
Cancer Res Treat. 2018;50(4):1252-1259.   Published online January 2, 2018
DOI: https://doi.org/10.4143/crt.2017.438
AbstractAbstract PDFPubReaderePub
Purpose
Fibroblast growth factor (FGF) signals are important in carcinogenesis and progression of prostate cancer. Dovitinib is an oral, pan-class inhibitor of vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor, and fibroblast growth factor receptor (FGFR). We evaluated the efficacy and toxicity of dovitinib in men with metastatic castration resistant prostate cancer (mCRPC).
Materials and Methods
This study was a single-arm, phase II, open-label, multicenter trial of dovitinib 500 mg/day (5-days-on/2-days-off schedule). The primary endpointwas 16-week progression-free survival (PFS). Secondary endpoints were overall survival (OS), toxicity and prostate-specific antigen (PSA) response rate. Biomarker analyses for VEGFR2, FGF23, and FGFR2 using multiplex enzyme-linked immunosorbent assay was performed.
Results
Forty-four men were accrued from 11 hospitals. Eighty percent were post-docetaxel. Median PSA was 100 ng/dL, median age was 69, 82% had bone metastases, and 23% had liver metastases. Median cycles of dovitinibwas 2 (range, 0 to 33). Median PFSwas 3.67 months (95% confidence interval [CI], 1.36 to 5.98) and median OS was 13.70 months (95% CI, 0 to 27.41). Chemotherapy-naïve patients had longer PFS (17.90 months; 95% CI, 9.23 to 28.57) compared with docetaxel-treated patients (2.07 months; 95% CI, 1.73 to 2.41; p=0.001) and the patients with high serum VEGFR2 level over median level (7,800 pg/mL) showed longer PFS compared with others (6.03 months [95% CI, 4.26 to 7.80] vs. 1.97 months [95% CI, 1.79 to 2.15], p=0.023). Grade 3 related adverse events were seen in 40.9% of patients. Grade 1-2 nausea, diarrhea, fatigue, anorexia, and all grade thrombocytopenia are common.
Conclusion
Dovitinib showed modest antitumor activity with manageable toxicities in men with mCRPC. Especially, patients who were chemo-naïve benefitted from dovitinib.

Citations

Citations to this article as recorded by  
  • Comprehensive Review on Recent Strategies for Management of Prostate Cancer: Therapeutic Targets and SAR
    Manish Chaudhary, Shubham Kumar, Paranjeet Kaur, Sanjeev Kumar Sahu, Amit Mittal
    Mini-Reviews in Medicinal Chemistry.2024; 24(7): 721.     CrossRef
  • Role of Basic Fibroblast Growth Factor in Cancer: Biological Activity, Targeted Therapies, and Prognostic Value
    Alessio Ardizzone, Valentina Bova, Giovanna Casili, Alberto Repici, Marika Lanza, Raffaella Giuffrida, Cristina Colarossi, Marzia Mare, Salvatore Cuzzocrea, Emanuela Esposito, Irene Paterniti
    Cells.2023; 12(7): 1002.     CrossRef
  • Case Report of a Glioma Patient with Homozygous Missense Amino Acid Substitution in KDR Gene
    Kalyan Ram Uppaluri, Himavanth Reddy Kambalachenu, Hima Jyothi Challa, Saadvik Raghuram Y., Deepak Sharma, Ramya Gadicherla, Srinivas Ketavath, Kalyani Palasamudram, Sri Manjari K.
    Indian Journal of Medical and Paediatric Oncology.2023; 44(03): 356.     CrossRef
  • FGFR families: biological functions and therapeutic interventions in tumors
    Qing Liu, Jiyu Huang, Weiwei Yan, Zhen Liu, Shu Liu, Weiyi Fang
    MedComm.2023;[Epub]     CrossRef
  • Targeting transforming growth factor‐ß signalling for cancer prevention and intervention: Recent advances in developing small molecules of natural origin
    Devesh Tewari, Anu Priya, Anusha Bishayee, Anupam Bishayee
    Clinical and Translational Medicine.2022;[Epub]     CrossRef
  • Evaluation of the therapeutic potential of masitinib and expression of its specific targets c‐Kit, PDGFR‐α, PDGFR‐β, and Lyn in canine prostate cancer cell lines
    Katharina Klose, Eva‐Maria Packeiser, José‐Luis Granados‐Soler, Marion Hewicker‐Trautwein, Hugo Murua Escobar, Ingo Nolte
    Veterinary and Comparative Oncology.2022; 20(3): 641.     CrossRef
  • Phase 2 Study of Neoadjuvant FGFR Inhibition and Androgen Deprivation Therapy Prior to Prostatectomy
    Elizabeth Liow, Nicholas Howard, Chol-Hee Jung, Bernard Pope, Bethany K. Campbell, Anne Nguyen, Michael Kerger, Jonathan B. Ruddle, Angelyn Anton, Benjamin Thomas, Kevin Chu, Philip Dundee, Justin S. Peters, Anthony J. Costello, Andrew S. Ryan, Christophe
    Clinical Genitourinary Cancer.2022; 20(5): 452.     CrossRef
  • There are gremlins in prostate cancer
    Laura A. Sena, W. Nathaniel Brennen, John T. Isaacs
    Nature Cancer.2022; 3(5): 530.     CrossRef
  • Targeting signaling pathways in prostate cancer: mechanisms and clinical trials
    Yundong He, Weidong Xu, Yu-Tian Xiao, Haojie Huang, Di Gu, Shancheng Ren
    Signal Transduction and Targeted Therapy.2022;[Epub]     CrossRef
  • Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids
    Ankit Kumar Singh, Adarsh Kumar, Harshwardhan Singh, Pankaj Sonawane, Harshali Paliwal, Suresh Thareja, Prateek Pathak, Maria Grishina, Mariusz Jaremko, Abdul-Hamid Emwas, Jagat Pal Yadav, Amita Verma, Habibullah Khalilullah, Pradeep Kumar
    Pharmaceuticals.2022; 15(9): 1071.     CrossRef
  • The FGF/FGFR system in the physiopathology of the prostate gland
    Arianna Giacomini, Elisabetta Grillo, Sara Rezzola, Domenico Ribatti, Marco Rusnati, Roberto Ronca, Marco Presta
    Physiological Reviews.2021; 101(2): 569.     CrossRef
  • Signaling Pathways That Control Apoptosis in Prostate Cancer
    Amaal Ali, George Kulik
    Cancers.2021; 13(5): 937.     CrossRef
  • A Review of the Pathophysiological Mechanisms Underlying Castration-resistant Prostate Cancer
    Fionnuala Crowley, Michelle Sterpi, Conor Buckley, Lauren Margetich, Shivani Handa, Zach Dovey
    Research and Reports in Urology.2021; Volume 13: 457.     CrossRef
  • Neoadjuvant Treatment with Angiogenesis-Inhibitor Dovitinib Prior to Local Therapy in Hepatocellular Carcinoma: A Phase II Study
    F.J. Sherida H. Woei-A-Jin, Nir I. Weijl, Mark C. Burgmans, Arantza Fariña Sarasqueta, J. Tom van Wezel, Martin N.J.M. Wasser, Minneke J. Coenraad, Jacobus Burggraaf, Susanne Osanto
    The Oncologist.2021; 26(10): 854.     CrossRef
  • Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment
    Peiyuan Zhang, Xiaohui Liu, Daniel Abegg, Toru Tanaka, Yuquan Tong, Raphael I. Benhamou, Jared Baisden, Gogce Crynen, Samantha M. Meyer, Michael D. Cameron, Arnab K. Chatterjee, Alexander Adibekian, Jessica L. Childs-Disney, Matthew D. Disney
    Journal of the American Chemical Society.2021; 143(33): 13044.     CrossRef
  • Bone microenvironment signaling of cancer stem cells as a therapeutic target in metastatic prostate cancer
    Clara H. Lee, Ann M. Decker, Frank C. Cackowski, Russell S. Taichman
    Cell Biology and Toxicology.2020; 36(2): 115.     CrossRef
  • Brivanib, a multitargeted small‐molecule tyrosine kinase inhibitor, suppresses laser‐induced CNV in a mouse model of neovascular AMD
    Lele Li, Manhui Zhu, Wenli Wu, Bai Qin, Jiayi Gu, Yuanyuan Tu, Jianing Chen, Dong Liu, Yunwei Shi, Xiaojuan Liu, Aimin Sang, Dongmei Ding
    Journal of Cellular Physiology.2020; 235(2): 1259.     CrossRef
  • In Vitro Effect of Dovitinib (TKI258), a Multi-Target Angiokinase Inhibitor on Aggressive Meningioma Cells
    Arabinda Das, Jaime L. Martinez Santos, Mohammed Alshareef, Guilherme Bastos Ferreira Porto, Libby Kosnik Infinger, William A. Vandergrift, Scott M. Lindhorst, Abhay K. Varma, Sunil J. Patel, David Cachia
    Cancer Investigation.2020; 38(6): 349.     CrossRef
  • Potential Role of Targeting KDR and Proteasome Inhibitors in the Therapy of Esophageal Squamous Cell Carcinoma
    Ling Zhang, Xia Niu, Yanghui Bi, Heyang Cui, Hongyi Li, Xiaolong Cheng
    Technology in Cancer Research & Treatment.2020;[Epub]     CrossRef
  • Novel Therapeutic Strategies for CDK4/6 Inhibitors in Metastatic Castrate-Resistant Prostate Cancer


    Adam M. Kase, John A. Copland, Winston Tan
    OncoTargets and Therapy.2020; Volume 13: 10499.     CrossRef
  • Therapeutic implications of fibroblast growth factor receptor inhibitors in a combination regimen for solid tumors (Review)
    Hong Luo, Tao Zhang, Peng Cheng, Dong Li, Oleksandr Ogorodniitchouk, Chaimaa Lahmamssi, Ge Wang, Meiling Lan
    Oncology Letters.2020; 20(3): 2525.     CrossRef
  • Dovitinib Triggers Apoptosis and Autophagic Cell Death by Targeting SHP-1/p-STAT3 Signaling in Human Breast Cancers
    Yi-Han Chiu, Yi-Yen Lee, Kuo-Chin Huang, Cheng-Chi Liu, Chen-Si Lin
    Journal of Oncology.2019; 2019: 1.     CrossRef
  • Tumour-stroma ratio and 5-year mortality in gastric adenocarcinoma: a systematic review and meta-analysis
    Niko Kemi, Maarit Eskuri, Joonas H. Kauppila
    Scientific Reports.2019;[Epub]     CrossRef
  • Investigational fibroblast growth factor receptor 2 antagonists in early phase clinical trials to treat solid tumors
    Dan Wang, Li Yang, Weina Yu, Yi Zhang
    Expert Opinion on Investigational Drugs.2019; 28(10): 903.     CrossRef
  • A Novel FGFR3 Splice Variant Preferentially Expressed in African American Prostate Cancer Drives Aggressive Phenotypes and Docetaxel Resistance
    Jacqueline Olender, Bi-Dar Wang, Travers Ching, Lana X. Garmire, Kaitlin Garofano, Youngmi Ji, Tessa Knox, Patricia Latham, Kenneth Nguyen, Johng Rhim, Norman H. Lee
    Molecular Cancer Research.2019; 17(10): 2115.     CrossRef
  • Recent Advances in Prostate Cancer Treatment and Drug Discovery
    Ekaterina Nevedomskaya, Simon J. Baumgart, Bernard Haendler
    International Journal of Molecular Sciences.2018; 19(5): 1359.     CrossRef
  • 10,956 View
  • 246 Download
  • 28 Web of Science
  • 26 Crossref
Close layer
Score for the Survival Probability in Metastasis Breast Cancer: A Nomogram-Based Risk Assessment Model
Zhenchong Xiong, Guangzheng Deng, Xinjian Huang, Xing Li, Xinhua Xie, Jin Wang, Zeyu Shuang, Xi Wang
Cancer Res Treat. 2018;50(4):1260-1269.   Published online January 2, 2018
DOI: https://doi.org/10.4143/crt.2017.443
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Survival of metastatic breast cancer (MBC) patient remains unknown and varies greatly from person to person. Thus, we aimed to construct a nomogram to quantify the survival probability of patients with MBC.
Materials and Methods
We had included 793 MBC patients and calculated trends of case fatality rate by Kaplan-Meier method and joinpoint regression. Six hundred thirty-four patients with MBC between January 2004 and July 2011 and 159 patients with MBC between August 2011 and July 2013 were assigned to training cohort and internal validation cohort, respectively. We constructed the nomogram based on the results of univariable and multivariable Cox regression analyses in the training cohort and validated the nomogram in the validation cohort. Concordance index and calibration curves were used to assess the effectiveness of nomogram.
Results

Case
fatality rate of MBC was increasing (annual percentage change [APC], 21.6; 95% confidence interval [CI], 1.0 to 46.3; p < 0.05) in the first 18 months and then decreased (APC, ‒4.5; 95% CI, ‒8.2 to ‒0.7; p < 0.05). Metastasis-free interval, age, metastasis location, and hormone receptor status were independent prognostic factors and were included in the nomogram, which had a concordance index of 0.69 in the training cohort and 0.67 in the validation cohort. Calibration curves indicated good consistency between the two cohorts at 1 and 3 years.
Conclusion
In conclusion, the fatality risk of MBC was increasing and reached the summit between 13th and 18th month afterthe detection of MBC. We have developed and validated a nomogram to predict the 1- and 3-year survival probability in MBC.

Citations

Citations to this article as recorded by  
  • Multiparametric Quantitative Imaging in Risk Prediction: Recommendations for Data Acquisition, Technical Performance Assessment, and Model Development and Validation
    Erich P. Huang, Gene Pennello, Nandita M. deSouza, Xiaofeng Wang, Andrew J. Buckler, Paul E. Kinahan, Huiman X. Barnhart, Jana G. Delfino, Timothy J. Hall, David L. Raunig, Alexander R. Guimaraes, Nancy A. Obuchowski
    Academic Radiology.2023; 30(2): 196.     CrossRef
  • Development and validation of nomograms to predict survival in patients with invasive micropapillary carcinoma of the breast
    Yixin Cheng, Pengkun Zhang, Yulin Huang, Zhihui Zhang, Ru Tang, Feng Chi, Jia-Yuan Sun, Zhenyu He
    BMJ Open.2023; 13(2): e065312.     CrossRef
  • Developing and validating nomograms for predicting the survival in patients with clinical local-advanced gastric cancer
    Chong Hou, Fangxu Yin, Yipin Liu
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Development and validation of a risk stratification nomogram for predicting prognosis in bone metastatic breast cancer
    Niuniu Hou, Jun Yi, Zhe Wang, Lu Yang, Ying Wu, Meiling Huang, Guangdong Hou, Rui Ling
    Medicine.2021; 100(6): e24751.     CrossRef
  • A Nomogram for Predicting Survival in Patients With Breast Cancer Liver Metastasis: A Population-Based Study
    Yu Xiong, Xia Shi, Qi Hu, Xingwei Wu, Enwu Long, Yuan Bian
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Prognostic Factors and a Nomogram Predicting Survival in Patients with Breast Ductal Carcinoma in situ with Microinvasion: A Population-Based Study
    Yi-Zi Zheng, Hong-Bin Qin, Zi-Zheng Li, He-Sheng Jiang, Greg Zhang, Shi-Wei Yang, Xian-Ming Wang, Yang-Chun Xu, Zhen-Han Deng, Guo-Wen Liu
    Clinical Epidemiology.2021; Volume 13: 1095.     CrossRef
  • The E3 Ubiquitin Ligase Cbl-b Predicts Favorable Prognosis in Breast Cancer
    Xiuming Liu, Yuee Teng, Xin Wu, Zhi Li, Bowen Bao, Yunpeng Liu, Xiujuan Qu, Lingyun Zhang
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Prognostic Factors for Premenopausal Women with Distant Metastatic Breast Cancer
    Jeungho Seung, Jai Min Ryu, Seok Jin Nam, Jeong Eon Lee, Jonghan Yu, Se Kyung Lee, Byung Joo Chae, Seok Won Kim
    Journal of Breast Disease.2020; 8(1): 1.     CrossRef
  • Primary 21-Gene Recurrence Score and Disease Outcome in Loco-Regional and Distant Recurrent Breast Cancer Patients
    Yujie Lu, Yiwei Tong, Jiahui Huang, Lin Lin, Jiayi Wu, Xiaochun Fei, Ou Huang, Jianrong He, Li Zhu, Weiguo Chen, Yafen Li, Xiaosong Chen, Kunwei Shen
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Independent risk factors evaluation for overall survival and cancer-specific survival in thyroid cancer patients with bone metastasis
    Yuexin Tong, Zhangheng Huang, Chuan Hu, Changxing Chi, Meng Lv, Pengfei Li, Chengliang Zhao, Youxin Song
    Medicine.2020; 99(36): e21802.     CrossRef
  • A nomogram for predicting survival in patients with de novo metastatic breast cancer: a population-based study
    Wen Zhao, Lei Wu, Andi Zhao, Mi Zhang, Qi Tian, Yanwei Shen, Fan Wang, Biyuan Wang, Le Wang, Ling Chen, Xiaoai Zhao, Danfeng Dong, Lingxiao Zhang, Jin Yang
    BMC Cancer.2020;[Epub]     CrossRef
  • Establishing a predicted model to evaluate prognosis for initially diagnosed metastatic Her2-positive breast cancer patients and exploring the benefit from local surgery
    Hong Lin, Yanxuan Wu, Guoxi Liang, Liming Chen, Anna Sapino
    PLOS ONE.2020; 15(11): e0242155.     CrossRef
  • Predictors of time to death after distant recurrence in breast cancer patients
    Victoria Sopik, Ping Sun, Steven A. Narod
    Breast Cancer Research and Treatment.2019; 173(2): 465.     CrossRef
  • Prognostic nomogram for patients with non-metastatic HER2 positive breast cancer in a prospective cohort
    Chuanxu Luo, Xiaorong Zhong, Zhu Wang, Yu Wang, Yanping Wang, Ping He, Qian Peng, Hong Zheng
    The International Journal of Biological Markers.2019; 34(1): 41.     CrossRef
  • B2 Prognostic Score: External Validation of a Clinical Decision-making Tool for Metastatic Breast Cancer
    Tanja Nadine Stueber, Manfred Wischnewsky, Elena Leinert, Joachim Diessner, Catharina Bartmann, Roland Gregor Stein, Achim Woeckel
    Clinical Breast Cancer.2019; 19(5): 333.     CrossRef
  • Development and Validation of a Nomogram for Predicting Survival in Male Patients With Breast Cancer
    Siying Chen, Yang Liu, Jin Yang, Qingqing Liu, Haisheng You, Yalin Dong, Jun Lyu
    Frontiers in Oncology.2019;[Epub]     CrossRef
  • Could local surgery improve survival in de novo stage IV breast cancer?
    Zhenchong Xiong, Guangzheng Deng, Jin Wang, Xing Li, Xinhua Xie, Zeyu Shuang, Xi Wang
    BMC Cancer.2018;[Epub]     CrossRef
  • 10,744 View
  • 213 Download
  • 16 Web of Science
  • 17 Crossref
Close layer
Factors Associated with Prolonged Patient-Attributable Delay in the Diagnosis of Colorectal Cancer
Irene Zarcos-Pedrinaci, Teresa Téllez, Francisco Rivas-Ruiz, María del Carmen Padilla-Ruiz, Julia Alcaide, Antonio Rueda, María Luisa Baré, María Manuela Morales Suárez-Varela, Eduardo Briones, Cristina Sarasqueta, Nerea Fernández-Larrea, Antonio Escobar, José María Quintana, Maximino Redondo, REDISSEC-CARESS/CCR group
Cancer Res Treat. 2018;50(4):1270-1280.   Published online January 2, 2018
DOI: https://doi.org/10.4143/crt.2017.371
AbstractAbstract PDFPubReaderePub
Purpose
The delayed diagnosis of colorectal cancer (CRC) may be attributable to sociodemographic characteristics, to aspects of tumour histopathology or to the functioning of the health system. We seek to determine which of these factors most influences prolonged patient-attributable delay (PPAD) in the diagnosis and treatment of CRC.
Materials and Methods
A prospective, multicentre observational study was conducted in 22 Spanish hospitals. In total, 1,785 patients were recruited to the study between 2010 and 2012 and underwent elective or urgent surgery. PPAD is considered to occur when the time elapsed between a patient presenting the symptom and him/her seeking attention from the primary care physician or hospital emergency department exceeds 180 days. A bivariate analysis was performed to assess differences in variables segmented by tumour location and patient delay. Multivariate logistic regression analysis was performed on the outcome variable, PPAD.
Results
The rate of PPAD among this population was 12.1%. PPAD was significantly associated with altered bowel rhythm (odds ratio [OR], 1.36; 95% confidence interval [CI], 1.02 to 1.83) and with adenocarcinoma histology, in comparison with mucinous adenocarcinoma (OR, 2.03; 95% CI, 1.11 to 3.71). Other sociocultural factors and clinicopathological features were not independent predictors of PPAD.
Conclusion
Many patients do not consider altered bowel rhythm an alarming symptom, warranting a visit to the doctor. PPAD could be reduced by improving health education, raising awareness of CRC-related symptoms.

Citations

Citations to this article as recorded by  
  • Improving colorectal cancer in Alberta, Canada: a qualitative study of patients and close contacts’ perceptions on diagnosis following an emergency department presentation
    Anna Pujadas Botey, Ashley J. Watson, Paula J. Robson
    BMC Health Services Research.2024;[Epub]     CrossRef
  • Sex differences in metastatic surgery following diagnosis of synchronous metastatic colorectal cancer
    Malin Ljunggren, Caroline E. Weibull, Gabriella Palmer, Emerik Osterlund, Bengt Glimelius, Anna Martling, Caroline Nordenvall
    International Journal of Cancer.2023; 152(3): 363.     CrossRef
  • Cancer awareness in older adults: Results from the Spanish Onco-barometer cross-sectional survey
    Dafina Petrova, Marina Pollán, Rocio Garcia-Retamero, Miguel Rodríguez-Barranco, Andrés Catena, Lucia Castillo Portellano, Maria-José Sánchez
    International Journal of Nursing Studies.2023; 140: 104466.     CrossRef
  • Perceived barriers to early presentation and symptom-specific time to seek medical advice for possible colorectal cancer symptoms among Palestinians
    Mohamedraed Elshami, Mohammed Ayyad, Fatma Khader Hamdan, Mohammed Alser, Ibrahim Al-Slaibi, Shoruq Ahmed Naji, Balqees Mustafa Mohamad, Wejdan Sudki Isleem, Adela Shurrab, Bashar Yaghi, Yahya Ayyash Qabaja, Mohammad Fuad Dwikat, Raneen Raed Sweity, Remah
    Scientific Reports.2023;[Epub]     CrossRef
  • Influence of Diagnostic Delay on Survival Rates for Patients with Colorectal Cancer
    María Padilla-Ruiz, María Morales-Suárez-Varela, Francisco Rivas-Ruiz, Julia Alcaide, Esperanza Varela-Moreno, Irene Zarcos-Pedrinaci, Teresa Téllez, Nerea Fernández-de Larrea-Baz, Marisa Baré, Amaia Bilbao, Cristina Sarasqueta, Urko Aguirre-Larracoechea,
    International Journal of Environmental Research and Public Health.2022; 19(6): 3626.     CrossRef
  • Patient delay to diagnosis and its predictors among colorectal cancer patients: A cross-sectional study based on the Theory of Planned Behavior
    Ying Jin, Mei-Chun Zheng, Xia Yang, Ting-Lan Chen, Jun-E Zhang
    European Journal of Oncology Nursing.2022; 60: 102174.     CrossRef
  • Advanced stage presentation and its determinant factors among colorectal cancer patients in Amhara regional state Referral Hospitals, Northwest Ethiopia
    Mulugeta Wassie, Debrework Tesgera Beshah, Yenework Mulu Tiruneh, Negar Rezaei
    PLOS ONE.2022; 17(10): e0273692.     CrossRef
  • Suppression of LETM1 inhibits the proliferation and stemness of colorectal cancer cells through reactive oxygen species–induced autophagy
    Nan Che, Zhaoting Yang, Xingzhe Liu, Mengxuan Li, Ying Feng, Chengye Zhang, Chao Li, Yan Cui, Yanhua Xuan
    Journal of Cellular and Molecular Medicine.2021; 25(4): 2110.     CrossRef
  • Assessing Knowledge, Physician Interactions and Patient-Reported Barriers to Colorectal Cancer Screening Among Arab Americans in Dearborn, Michigan
    Fatima Saad, Mariam Ayyash, Marwa Ayyash, Nadine Elhage, Iman Ali, Mona Makki, Hiam Hamade, R. Alexander Blackwood
    Journal of Community Health.2020; 45(5): 900.     CrossRef
  • Targeting Receptor Kinases in Colorectal Cancer
    Marilina García-Aranda, Maximino Redondo
    Cancers.2019; 11(4): 433.     CrossRef
  • 9,131 View
  • 132 Download
  • 11 Web of Science
  • 10 Crossref
Close layer
Geographical Variations and Trends in Major Cancer Incidences throughout Korea during 1999-2013
Young-Joo Won, Kyu-Won Jung, Chang-Mo Oh, Eun-Hye Park, Hyun-Joo Kong, Duk Hyoung Lee, Kang Hyun Lee, The Community of Population-based Regional Cancer Registries
Cancer Res Treat. 2018;50(4):1281-1293.   Published online January 4, 2018
DOI: https://doi.org/10.4143/crt.2017.411
AbstractAbstract PDFPubReaderePub
Purpose
We aimed to describe the temporal trends and district-level geographical variations in cancer incidences throughout Korea during 1999-2013.
Materials and Methods
Data were obtained from the Korean National Cancer Incidence Database. We calculated the age-standardized cumulative cancerincidences according to sex and geographicalregion (metropolitan cities, provinces, and districts) for three 5-year periods (1999-2003, 2004- 2008, and 2009-2013). Each quintile interval contained the same number of regions. Disease maps were created to visualize regional differences in the cancer incidences.
Results
Substantial differences in cancer incidences were observed according to district and cancer type. The largest variations between geographical regions were found for thyroid cancer among both men and women. There was little variation in the incidences of stomach, colorectal, and lung cancer according to geographical region. Substantially elevated incidences of specific cancers were observed in Jeollanam-do (thyroid); Daejeon (colorectum); Jeollanam-do, Gyeongsangbuk-do, and Chungcheongbuk-do (lung); Seocho-gu, Gangnam-gu and Seongnam, Bundang-gu (breast and prostate); Chungcheong and Gyeongsang provinces (stomach); Ulleung-gun and the southern districts of Gyeongsangnam-do and Jeollanam-do (liver); and along the Nakdonggang River (gallbladder and biliary tract).
Conclusion
Mapping regional cancer incidences in Korea allowed us to compare the results according to geographical region. Our results may facilitate the development of infrastructure for systematic cancerincidence monitoring,which could promote the planning and implementation of region-specific cancer management programs.

Citations

Citations to this article as recorded by  
  • Exploring age-standardized cancer incidence rates and regional disparities: A retrospective cohort study of 8 major cancers in South Korea
    Dagyeong Lee, Hye-won Yun, Nayeon Kim, Juwon Park, Kyu-won Jung, Mina Suh, Dong Wook Shin
    Cancer Epidemiology.2024; 91: 102594.     CrossRef
  • Descriptive Analysis of Gastric Cancer Mortality in Korea, 2000-2020
    Tung Hoang, Hyeongtaek Woo, Sooyoung Cho, Jeeyoo Lee, Sayada Zartasha Kazmi, Aesun Shin
    Cancer Research and Treatment.2023; 55(2): 603.     CrossRef
  • Changes in spatial clusters of cancer incidence and mortality over 15 years in South Korea: Implication to cancer control
    Cham Thi Nguyen, Insang Song, Inkyung Jung, Yoon‐Jung Choi, Sun‐Young Kim
    Cancer Medicine.2023; 12(16): 17418.     CrossRef
  • Spatio-temporal trends of the age-at-menarche percentiles among Portuguese women since 1920
    Vitor Rodrigues, Rui Martins, Bruno de Sousa
    BMC Women's Health.2023;[Epub]     CrossRef
  • Regional disparities in major cancer incidence in Korea, 1999-2018
    Eun Hye Park, Mee Joo Kang, Kyu-Won Jung, Eun Hye Park, E Hwa Yun, Hye-Jin Kim, Hyun-Joo Kong, Chang Kyun Choi, Jeong-Soo Im, Hong Gwan Seo
    Epidemiology and Health.2023; 45: e2023089.     CrossRef
  • Estimation of Utility Weights for Prostate-related Health States in Korea
    Seon-Ha Kim, Minsu Ock, Min-Woo Jo, Sungchan Park
    Journal of Preventive Medicine and Public Health.2022; 55(3): 243.     CrossRef
  • A comparison of quality of life between patients with small and large gastric remnant volumes after gastrectomy for gastric cancer
    Jae-Seok Min, Sang-Ho Jeong, Ji-Ho Park, Taehan Kim, Eun-Jung Jung, Young-Tae Ju, Chi-Young Jeong, Ju-Yeon Kim, Miyeong Park, Young-Joon Lee
    Medicine.2021; 100(33): e26954.     CrossRef
  • Spatial epidemiologic analysis of the liver cancer and gallbladder cancer incidence and its determinants in South Korea
    Jieun Jang, Dae-Sung Yoo, Byung Chul Chun
    BMC Public Health.2021;[Epub]     CrossRef
  • Spatial distribution and determinants of thyroid cancer incidence from 1999 to 2013 in Korea
    Jieun Jang, Dae-Sung Yoo, Byung Chul Chun
    Scientific Reports.2021;[Epub]     CrossRef
  • Family History of Gastric Cancer and Helicobacter pylori Treatment
    Il Ju Choi, Chan Gyoo Kim, Jong Yeul Lee, Young-Il Kim, Myeong-Cherl Kook, Boram Park, Jungnam Joo
    New England Journal of Medicine.2020; 382(5): 427.     CrossRef
  • Application of Epidemiological Geographic Information System: An Open-Source Spatial Analysis Tool Based on the OMOP Common Data Model
    Jaehyeong Cho, Seng Chan You, Seongwon Lee, DongSu Park, Bumhee Park, George Hripcsak, Rae Woong Park
    International Journal of Environmental Research and Public Health.2020; 17(21): 7824.     CrossRef
  • 9,393 View
  • 188 Download
  • 11 Web of Science
  • 11 Crossref
Close layer
The Association of Acquired T790M Mutation with Clinical Characteristics after Resistance to First-Line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in Lung Adenocarcinoma
Yen-Hsiang Huang, Kuo-Hsuan Hsu, Jeng-Sen Tseng, Kun-Chieh Chen, Chia-Hung Hsu, Kang-Yi Su, Jeremy J. W. Chen, Huei-Wen Chen, Sung-Liang Yu, Tsung-Ying Yang, Gee-Chen Chang
Cancer Res Treat. 2018;50(4):1294-1303.   Published online January 4, 2018
DOI: https://doi.org/10.4143/crt.2017.512
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The main objective of this study was to investigate the relationship among the clinical characteristics and the frequency of T790M mutation in advanced epidermal growth factor receptor (EGFR)‒mutant lung adenocarcinoma patients with acquired resistance after firstline EGFR‒tyrosine kinase inhibitor (TKI) treatment.
Materials and Methods
We enrolled EGFR-mutant stage IIIB-IV lung adenocarcinoma patients, who had progressed to prior EGFR-TKI therapy, and evaluated their rebiopsy EGFR mutation status.
Results
A total of 205 patients were enrolled for analysis. The overall T790M mutation rate of rebiopsy was 46.3%. The T790M mutation rates among patients with exon 19 deletion mutation, exon 21 L858R point mutation, and other mutations were 55.0%, 37.3%, and 27.3%, respectively. Baseline exon 19 deletion was associated with a significantly higher frequency of T790M mutation (adjusted odds ratio, 2.14; 95% confidence interval [CI], 1.20 to 3.83; p=0.010). In the exon 19 deletion subgroup, there was a greater prevalence of T790M mutation than other exon 19 deletion subtypes in patients with the Del E746-A750 mutation (61.6% vs. 40.6%; odds ratio, 2.35; 95% CI, 1.01 to 5.49; p=0.049). The progression-free survival (PFS) of first-line TKI treatment > 11 months was also associated with a higher T790M mutation rate (54.1% vs. 39.3%; adjusted odds ratio, 1.82; 95% CI, 1.02 to 3.25; p=0.044). Patients who underwent rebiopsy at metastatic sites had more chance to harbor T790M mutation (52.6% vs. 33.8%; adjusted odds ratio, 1.97; 95% CI, 1.06 to 3.67; p=0.032).
Conclusion
PFS of first-line EGFR-TKI, rebiopsy site, EGFR exon 19 deletion and its subtype Del E746- A750 mutation are associated with the frequency of T790M mutation.

Citations

Citations to this article as recorded by  
  • RELAY, Erlotinib Plus Ramucirumab in Untreated, EGFR-Mutated, Metastatic NSCLC: Outcomes by EGFR Exon 19 Deletion Variants
    Kazumi Nishino, Jin-Yuan Shih, Kazuhiko Nakagawa, Martin Reck, Edward B. Garon, Michelle Carlsen, Tomoko Matsui, Carla Visseren-Grul, Ernest Nadal
    JTO Clinical and Research Reports.2024; 5(2): 100624.     CrossRef
  • Epidermal Growth Factor Receptor Exon 19 Deletion Subtypes Do Not Influence Survival Outcomes Following First-line Epidermal Growth Factor Receptor-tyrosine Kinase Inhibitors in Advanced Nonsmall Cell Lung Cancer Patients
    Yan-Jei Tang, John Wen-Cheng Chang, Chen-Yang Huang, Yueh-Fu Fang, Ching-Fu Chang, Cheng-Ta Yang, Chih-Hsi Scott Kuo, Ping-Chih Hsu, Chiao-En Wu
    Journal of Cancer Research and Practice.2024; 11(1): 28.     CrossRef
  • CRISPR-Based Fluorescent Reporter (CBFR) Assay for Sensitive, Specific, Inexpensive, and Visual Detection of a Specific EGFR Exon 19 Deletion in NSCLC
    Pouya Salehipour, Mojdeh Mahdiannasser, Ghazal Sedaghat Shayegan, Kimia Shankaie, Mina Tabrizi, Majid Mojarrad, Mohammad Hossein Modarressi
    Molecular Biotechnology.2023; 65(5): 807.     CrossRef
  • Endobronchial ultrasound‐guided re‐biopsy of non–small cell lung cancer with acquired resistance after EGFR tyrosine kinase inhibitor treatment
    Kyung Soo Hong, Jinmo Cho, Jong Geol Jang, Min Hye Jang, June Hong Ahn
    Thoracic Cancer.2023; 14(4): 363.     CrossRef
  • Monitoring of T790M in plasma ctDNA of advanced EGFR-mutant NSCLC patients on first- or second-generation tyrosine kinase inhibitors
    Chun-Ta Huang, Chih-An Lin, Te-Jen Su, Ching-Yao Yang, Tzu-Hsiu Tsai, Chia-Lin Hsu, Wei-Yu Liao, Kuan-Yu Chen, Chao-Chi Ho, Chong-Jen Yu
    BMC Cancer.2023;[Epub]     CrossRef
  • Clinical outcomes of immune checkpoint inhibitors to treat non-small cell lung cancer patients harboring epidermal growth factor receptor mutations
    Jinfei Si, Yue Hao, Jingwen Wei, Jing Xiang, Chunwei Xu, Qiuping Shen, Zhengbo Song
    BMC Pulmonary Medicine.2023;[Epub]     CrossRef
  • FRET probe for detecting two mutations in one EGFR mRNA
    Myat Thu, Kouta Yanai, Hajime Shigeto, Shohei Yamamura, Kazunori Watanabe, Takashi Ohtsuki
    The Analyst.2023; 148(11): 2626.     CrossRef
  • Efficacy of Osimertinib in Patients with Lung Cancer Positive for Uncommon EGFR Exon 19 Deletion Mutations
    Michael J. Grant, Jacqueline V. Aredo, Jacqueline H. Starrett, Paul Stockhammer, Iris K. van Alderwerelt van Rosenburgh, Anna Wurtz, Andrew J. Piper-Valillo, Zofia Piotrowska, Christina Falcon, Helena A. Yu, Charu Aggarwal, Dylan Scholes, Tejas Patil, Chr
    Clinical Cancer Research.2023; 29(11): 2123.     CrossRef
  • NSCLC presents metabolic heterogeneity, and there is still some leeway for EGF stimuli in EGFR-mutated NSCLC
    Cindy Mendes, Isabel Lemos, Inês Francisco, Teresa Almodôvar, Fernando Cunha, Cristina Albuquerque, Luís G. Gonçalves, Jacinta Serpa
    Lung Cancer.2023; 182: 107283.     CrossRef
  • Clinical outcomes of advanced NSCLC patients with different EGFR exon 19 deletion subtypes treated with first‐line tyrosine kinase inhibitors: A single‐center ambispective cohort study
    Yangchun Gu, Jinyu Yu, Haifeng Hu, Hua Zhang, Baoshan Cao, Li Liang
    Thoracic Cancer.2023; 14(31): 3147.     CrossRef
  • Brain metastasis, EGFR mutation subtype and generation of EGFR-TKI jointly influence the treatment outcome of patient with EGFR-mutant NSCLC
    Jia-Shiuan Ju, Allen Chung-Cheng Huang, Pi-Hung Tung, Chi-Hsien Huang, Tzu-Hsuan Chiu, Chin-Chou Wang, How-Wen Ko, Fu-Tsai Chung, Ping-Chih Hsu, Yueh-Fu Fang, Yi-Ke Guo, Chih-Hsi Scott Kuo, Cheng-Ta Yang
    Scientific Reports.2023;[Epub]     CrossRef
  • Afatinib treatment in a large real‐world cohort of nonsmall cell lung cancer patients with common and uncommon epidermal growth factor receptor mutation
    Chi‐Hsien Huang, Jia‐Shiuan Ju, Tzu‐Hsuan Chiu, Allen Chung‐Cheng Huang, Pi‐Hung Tung, Chin‐Chou Wang, Chien‐Ying Liu, Fu‐Tsai Chung, Yueh‐Fu Fang, Yi‐Ke Guo, Chih‐Hsi Scott Kuo, Cheng‐Ta Yang
    International Journal of Cancer.2022; 150(4): 626.     CrossRef
  • The Clinical Outcomes of Different First-Line EGFR-TKIs Plus Bevacizumab in Advanced EGFR-Mutant Lung Adenocarcinoma
    Yen-Hsiang Huang, Kuo-Hsuan Hsu, Chun-Shih Chin, Jeng-Sen Tseng, Tsung-Ying Yang, Kun-Chieh Chen, Kang-Yi Su, Sung-Liang Yu, Jeremy J.W. Chen, Gee-Chen Chang
    Cancer Research and Treatment.2022; 54(2): 434.     CrossRef
  • Impact of EGFR exon 19 deletion subtypes on clinical outcomes in EGFR-TKI-Treated advanced non-small-cell lung cancer
    Le-Tian Huang, Shu-Ling Zhang, Cheng-Bo Han, Jie-Tao Ma
    Lung Cancer.2022; 166: 9.     CrossRef
  • Risk Stratification Using a Novel Nomogram for 2190 EGFR-Mutant NSCLC Patients Receiving the First or Second Generation EGFR-TKI
    John Wen-Cheng Chang, Chen-Yang Huang, Yueh-Fu Fang, Ching-Fu Chang, Cheng-Ta Yang, Chih-Hsi Scott Kuo, Ping-Chih Hsu, Chiao-En Wu
    Cancers.2022; 14(4): 977.     CrossRef
  • Impact of sequential therapy with osimertinib on the overall survival in patients with EGFR-mutant non-small cell lung cancer
    Minehiko Inomata, Masahiro Matsumoto, Isami Mizushima, Kana Hayashi, Zenta Seto, Kotaro Tokui, Chihiro Taka, Seisuke Okazawa, Kenta Kambara, Shingo Imanishi, Toshiro Miwa, Ryuji Hayashi, Shoko Matsui, Kazuyuki Tobe
    The Egyptian Journal of Bronchology.2022;[Epub]     CrossRef
  • Pretreatment Neutrophil-to-Lymphocyte Ratio and Smoking History as Prognostic Factors in Advanced Non–Small Cell Lung Cancer Patients Treated with Osimertinib
    Ji Young Park, Seung Hun Jang, Chang Youl Lee, Taehee Kim, Soo Jie Chung, Ye Jin Lee, Hwan Il Kim, Joo-Hee Kim, Sunghoon Park, Yong Il Hwang, Ki-Suck Jung
    Tuberculosis and Respiratory Diseases.2022; 85(2): 155.     CrossRef
  • Optimizing Patient Outcomes Through Sequential EGFR TKI Treatment in Asian Patients With EGFR Mutation-Positive NSCLC
    Rong Liu, Jianying Zhou, Xia Ling
    Clinical Medicine Insights: Oncology.2022;[Epub]     CrossRef
  • State-of-the-Art Molecular Oncology of Lung Cancer in Taiwan
    Yung-Hung Luo, Kung-Hao Liang, Hsu-Ching Huang, Chia-I Shen, Chi-Lu Chiang, Mong-Lien Wang, Shih-Hwa Chiou, Yuh-Min Chen
    International Journal of Molecular Sciences.2022; 23(13): 7037.     CrossRef
  • Real-World Testing Practices, Treatment Patterns and Clinical Outcomes in Patients from Central Eastern Europe with EGFR-Mutated Advanced Non-Small Cell Lung Cancer: A Retrospective Chart Review Study (REFLECT)
    Urška Janžič, Nina Turnšek, Mircea Dediu, Ivan Shterev Donev, Roxana Lupu, Gabriela Teodorescu, Tudor E. Ciuleanu, Adam Pluzanski
    Current Oncology.2022; 29(8): 5833.     CrossRef
  • Efficacy and Failure Patterns of Early SBRT to the Primary Tumor in Advanced EGFR-Mutation-Positive Lung Cancer with EFGR-TKI Treatment: A Prospective, Single Arm, Phase II Study
    Yangyang Shi, Hailing Xu, William Y. Raynor, Jiapei Ding, Ling Lin, Chao Zhou, Wei Wang, Yinnan Meng, Xiaomai Wu, Xiaofeng Chen, Dongqing Lv, Haihua Yang
    Life.2022; 12(12): 1954.     CrossRef
  • Association of hOGG1‐Cys variants with occurrence of p53 and EGFR deletion mutations in non‐small cell lung cancer
    Ming‐Jenn Chen, Ching‐Ju Shen, Lee Wang, Po‐Ming Chen, Chih‐Yi Chen, Huei Lee
    Thoracic Cancer.2021; 12(4): 534.     CrossRef
  • The Impact of Acquired EGFR T790M Mutation and EGFR Circulating Cell-Free DNA on Survival in Patients with Lung Adenocarcinoma Following EGFR-TKI Therapy
    Wen-Chien Cheng, Te-Chun Hsia, Chih-Yen Tu, Hung-Jen Chen
    OncoTargets and Therapy.2021; Volume 13: 13425.     CrossRef
  • EGFR-TKI plus bevacizumab versus EGFR-TKI monotherapy for patients with EGFR mutation-positive advanced non-small cell lung cancer-A propensity score matching analysis
    Jeng-Shiuan Tsai, Po-Lan Su, Szu-Chun Yang, Chao-Chun Chang, Chia-Ying Lin, Yi-Ting Yen, Yau-Lin Tseng, Wu-Wei Lai, Chien-Chung Lin, Wu-Chou Su
    Journal of the Formosan Medical Association.2021; 120(9): 1729.     CrossRef
  • The impact of different first-line EGFR-TKIs on the clinical outcome of sequential osimertinib treatment in advanced NSCLC with secondary T790M
    Yen-Hsiang Huang, Jeng-Sen Tseng, Kuo-Hsuan Hsu, Kun-Chieh Chen, Kang-Yi Su, Sung-Liang Yu, Jeremy J. W. Chen, Tsung-Ying Yang, Gee-Chen Chang
    Scientific Reports.2021;[Epub]     CrossRef
  • First- or second-generation epidermal growth factor receptor tyrosine kinase inhibitors in a large, real-world cohort of patients with non-small cell lung cancer
    Allen Chung-Cheng Huang, Chi-Hsien Huang, Jia-Shiuan Ju, Tzu-Hsuan Chiu, Pi-Hung Tung, Chin-Chou Wang, Chien-Ying Liu, Fu-Tsai Chung, Yueh-Fu Fang, Yi-Ke Guo, Chih-Hsi Scott Kuo, Cheng-Ta Yang
    Therapeutic Advances in Medical Oncology.2021;[Epub]     CrossRef
  • Association of EGFR Tyrosine Kinase Inhibitor Treatment With Progression-Free Survival Among Taiwanese Patients With Advanced Lung Adenocarcinoma and EGFR Mutation
    Po-Yen Chen, Chin-Chou Wang, Chien-Ning Hsu, Chung-Yu Chen
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Elevated exosome-derived miRNAs predict osimertinib resistance in non-small cell lung cancer
    Xinying Li, Cen Chen, Zimu Wang, Jiaxin Liu, Wei Sun, Kaikai Shen, Yanling Lv, Suhua Zhu, Ping Zhan, Tangfeng Lv, Yong Song
    Cancer Cell International.2021;[Epub]     CrossRef
  • Liquid Biopsy for EGFR Mutation Analysis in Advanced Non-Small-Cell Lung Cancer Patients: Thoughts Drawn from a Real-Life Experience
    Paola Ulivi, Elisabetta Petracci, Matteo Canale, Ilaria Priano, Laura Capelli, Daniele Calistri, Elisa Chiadini, Paola Cravero, Alice Rossi, Angelo Delmonte, Lucio Crinò, Giuseppe Bronte
    Biomedicines.2021; 9(10): 1299.     CrossRef
  • Real-world efficacy and safety of lorlatinib in treating advanced ALK-positive non–small cell lung cancer patients
    Po-Hsin Lee, Kun-Chieh Chen, Kuo-Hsuan Hsu, Yen-Hsiang Huang, Jeng-Sen Tseng, Tsung-Ying Yang, Gee-Chen Chang
    Anti-Cancer Drugs.2021; 32(10): 1099.     CrossRef
  • Clinical Features and Progression Pattern of Acquired T790M-positive Compared With T790M-negative EGFR Mutant Non–small-cell Lung Cancer: Catching Tumor and Clinical Heterogeneity Over Time Through Liquid Biopsy
    Alessandro Dal Maso, Martina Lorenzi, Elisa Roca, Sara Pilotto, Marianna Macerelli, Valentina Polo, Fabiana Letizia Cecere, Alessandro Del Conte, Giorgia Nardo, Vanessa Buoro, Daniela Scattolin, Sara Monteverdi, Loredana Urso, Elisabetta Zulato, Stefano F
    Clinical Lung Cancer.2020; 21(1): 1.     CrossRef
  • Association between programmed death-ligand 1 expression, immune microenvironments, and clinical outcomes in epidermal growth factor receptor mutant lung adenocarcinoma patients treated with tyrosine kinase inhibitors
    Ching-Yao Yang, Wei-Yu Liao, Chao-Chi Ho, Kuan-Yu Chen, Tzu-Hsiu Tsai, Chia-Lin Hsu, Kang-Yi Su, Yih-Leong Chang, Chen-Tu Wu, Chia-Chi Hsu, Bin-Chi Liao, Wei-Hsun Hsu, Jih-Hsiang Lee, Chia-Chi Lin, Jin-Yuan Shih, James C.-H. Yang, Chong-Jen Yu
    European Journal of Cancer.2020; 124: 110.     CrossRef
  • Comparison detection methods for EGFR in formalin-fixed paraffin-embedded tissues of patients with NSCLC
    Xiaojie Fan, Xiaoxiao Wang, Meng Zhang, Huiyan Deng, Yueping Liu
    Pathology - Research and Practice.2020; 216(1): 152783.     CrossRef
  • Clinical implication and usefulness of de novo EGFR T790M mutation in lung adenocarcinoma with EGFR-tyrosine kinase inhibitor sensitizing mutation
    Sang Hoon Lee, Eun Young Kim, Arum Kim, Yoon Soo Chang
    Cancer Biology & Therapy.2020; 21(8): 741.     CrossRef
  • Post-Progression Survival in Secondary EGFR T790M-Mutated Non-Small-Cell Lung Cancer Patients With and Without Osimertinib After Failure of a Previous EGFR TKI
    Chi-Lu Chiang, Hsu-Ching Huang, Chia-I Shen, Yung-Hung Luo, Yuh-Min Chen, Chao-Hua Chiu
    Targeted Oncology.2020; 15(4): 503.     CrossRef
  • An Observational Study of Acquired EGFR T790M-Dependent Resistance to EGFR-TKI Treatment in Lung Adenocarcinoma Patients in Taiwan
    Shang-Gin Wu, Chi-Lu Chiang, Chien-Ying Liu, Chin-Chou Wang, Po-Lan Su, Te-Chun Hsia, Jin-Yuan Shih, Gee-Chen Chang
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Refined Stratification Based on Baseline Concomitant Mutations and Longitudinal Circulating Tumor DNA Monitoring in Advanced EGFR-Mutant Lung Adenocarcinoma Under Gefitinib Treatment
    Jianchun Duan, JiaChen Xu, Zhijie Wang, Hua Bai, Ying Cheng, Tongtong An, Hongjun Gao, Kai Wang, Qing Zhou, Yanping Hu, Yong Song, Cuimin Ding, Feng Peng, Li Liang, Yi Hu, Cheng Huang, Caicun Zhou, Yuankai Shi, Jiefei Han, Di Wang, Yanhua Tian, Zhenlin Ya
    Journal of Thoracic Oncology.2020; 15(12): 1857.     CrossRef
  • A Highly Sensitive Next-Generation Sequencing-Based Genotyping Platform for EGFR Mutations in Plasma from Non-Small Cell Lung Cancer Patients
    Jung-Young Shin, Jeong-Oh Kim, Mi-Ran Lee, Seo Ree Kim, Kyongmin Sarah Beck, Jin Hyoung Kang
    Cancers.2020; 12(12): 3579.     CrossRef
  • Association of Tumor PD-L1 Expression with the T790M Mutation and Progression-Free Survival in Patients with EGFR-Mutant Non-Small Cell Lung Cancer Receiving EGFR-TKI Therapy
    Minehiko Inomata, Kenji Azechi, Naoki Takata, Kana Hayashi, Kotaro Tokui, Chihiro Taka, Seisuke Okazawa, Kenta Kambara, Shingo Imanishi, Toshiro Miwa, Ryuji Hayashi, Shoko Matsui, Kazuyuki Tobe
    Diagnostics.2020; 10(12): 1006.     CrossRef
  • Rare Mechanism of Acquired Resistance to Osimertinib in Korean Patients with EGFR-mutated Non-small Cell Lung Cancer
    Jiyun Lee, Joon Ho Shim, Woong-Yang Park, Hee Kyung Kim, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn
    Cancer Research and Treatment.2019; 51(1): 408.     CrossRef
  • Clinical outcomes and secondary epidermal growth factor receptor (EGFR) T790M mutation among first‐line gefitinib, erlotinib and afatinib‐treated non‐small cell lung cancer patients with activating EGFR mutations
    Yen‐Ting Lin, Jin‐Shing Chen, Wei‐Yu Liao, Chao‐Chi Ho, Chia‐Lin Hsu, Ching‐Yao Yang, Kuan‐Yu Chen, Jih‐Hsiang Lee, Zhong‐Zhe Lin, Jin‐Yuan Shih, James Chih‐Hsin Yang, Chong‐Jen Yu
    International Journal of Cancer.2019; 144(11): 2887.     CrossRef
  • Prior EGFR-TKI Treatment in EGFR-Mutated NSCLC Affects the Allele Frequency Fraction of Acquired T790M and the Subsequent Efficacy of Osimertinib
    Chih-Hsi Scott Kuo, Chi-Hsien Huang, Chien-Ying Liu, Stelios Pavlidis, Ho-Wen Ko, Fu-Tsai Chung, Tin-Yu Lin, Chih-Liang Wang, Yi-Ke Guo, Cheng-Ta Yang
    Targeted Oncology.2019; 14(4): 433.     CrossRef
  • Frecuencia de mutación T790M determinada por biopsia líquida en pacientes con cáncer pulmonar de células no pequeñas después de la progresión a inhibidores de tirosina cinasa contra EGFR en primera línea
    Jorge Arturo Alatorre-Alexander, Patricio Santillán-Doherty, María del Rosario Flores-Soto, Luis Manuel Martínez-Barrera, Jerónimo Rafael Rodríguez-Cid, Carla Paola Sánchez-Ríos
    NCT Neumología y Cirugía de Tórax.2019; 78(4): 348.     CrossRef
  • 12,597 View
  • 598 Download
  • 47 Web of Science
  • 43 Crossref
Close layer
Induction Chemotherapy Plus Concurrent Chemoradiotherapy Versus Concurrent Chemoradiotherapy Alone in Locoregionally Advanced Nasopharyngeal Carcinoma in Children and Adolescents: A Matched Cohort Analysis
Yang Li, Lin-Quan Tang, Li-Ting Liu, Shan-Shan Guo, Yu-Jing Liang, Xue-Song Sun, Qing-Nan Tang, Jin-Xin Bei, Jing Tan, Shuai Chen, Jun Ma, Chong Zhao, Qiu-Yan Chen, Hai-Qiang Mai
Cancer Res Treat. 2018;50(4):1304-1315.   Published online January 8, 2018
DOI: https://doi.org/10.4143/crt.2017.463
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The purpose of this study was to evaluate the long-term clinical outcome and toxicity of induction chemotherapy (IC) followed by concomitant chemoradiotherapy (CCRT) compared with CCRT alone for the treatment of children and adolescent locoregionally advanced nasopharyngeal carcinoma (LACANPC).
Materials and Methods
A total of 194 locoregionally advanced nasopharyngeal carcinoma patients youngerthan 21 years who received CCRT with or without IC before were included in the study population. Overall survival (OS) rate, progression-free survival (PFS) rate, locoregional recurrence-free survival (LRFS) rate, and distant metastasis-free survival (DMFS) rate were assessed by the Kaplan-Meier method and a log-rank test. Treatment toxicities were clarified and compared between two groups.
Results
One hundred and thiry of 194 patients received IC+CCRT. Patients who were younger and with more advanced TNM stage were more likely to receive IC+CCRT and intensive modulated radiotherapy. The addition of IC before CCRT failed to improve survival significantly. The matched analysis identified 43 well-balanced patients in both two groups. With a median follow-up of 51.5 months, no differences were found between the IC+CCRT group and the CCRT group in 5-year OS (83.7% vs. 74.6%, p=0.153), PFS (79.2% vs. 73.4%, p=0.355), LRFS (97.7% vs. 88.2%, p=0.083), and DMFS (81.6% vs. 81.6%, p=0.860). N3 was an independent prognostic factor predicting poorer OS, PFS, and DMFS. The addition of IC was associated with increased rates of grade 3 to 4 neutropenia.
Conclusion
This study failed to demonstrate that adding IC before CCRT could provide a significant additional survival benefit for LACANPC patients. Further investigations are warranted.

Citations

Citations to this article as recorded by  
  • Nasopharyngeal Carcinoma in Children, Current Treatment Approach
    Tal Ben-Ami
    Journal of Pediatric Hematology/Oncology.2024; 46(3): 117.     CrossRef
  • Concurrent chemoradiotherapy with or without neoadjuvant chemotherapy in pediatric patients with stage III-IVa nasopharyngeal carcinoma: a real-world propensity score-matched cohort study
    Ya-Nan Jin, Zhao-Hui Ruan, Wan-Wei Cao, Lin Yang, Wei Yao, Xiao-Feng Pei, Wang-Jian Zhang, Tia Marks, Ji-Jin Yao, Liang-Ping Xia
    Journal of Cancer Research and Clinical Oncology.2023; 149(13): 11929.     CrossRef
  • Epidemiology and treatment of head and neck malignancies in the AYA generation
    Takahiro Asakage
    International Journal of Clinical Oncology.2022; 27(3): 465.     CrossRef
  • Association of Treatment Advances With Survival Rates in Pediatric Patients With Nasopharyngeal Carcinoma in China, 1989-2020
    Yu-Jing Liang, Li-Ting Liu, Yang Li, Pan Wang, Mei-Juan Luo, Dong-Xiang Wen, Qiu-Yan Chen, Hai-Qiang Mai
    JAMA Network Open.2022; 5(3): e220173.     CrossRef
  • LHX2 facilitates the progression of nasopharyngeal carcinoma via activation of the FGF1/FGFR axis
    Tao Xie, Kunpeng Du, Wei Liu, Chunshan Liu, Baiyao Wang, Yunhong Tian, Rong Li, Xiaoting Huang, Jie Lin, Haifeng Jian, Jian Zhang, Yawei Yuan
    British Journal of Cancer.2022; 127(7): 1239.     CrossRef
  • Exploring the Optimal Chemotherapy Strategy for Locoregionally Advanced Children and Adolescent Nasopharyngeal Carcinoma Based on Pretreatment Epstein-Barr Virus DNA Level in the Era of Intensity Modulated Radiotherapy
    Ziyi Zeng, Chen Chen, Lanlan Guo, Cheng Zhang, Lei Chen, Chuanping Yuan, Lixia Lu
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Optimal cumulative cisplatin dose during concurrent chemoradiotherapy among children and adolescents with locoregionally advanced nasopharyngeal carcinoma: A real-world data study
    Ya-Nan Jin, Ji-Jin Yao, Ya-Fei You, Hui-Jiao Cao, Zi-Zi Li, Dan-Ling Dai, Wang-Jian Zhang, Tia Marks, Bei Zhang, Liang-Ping Xia
    Radiotherapy and Oncology.2021; 161: 83.     CrossRef
  • Nasopharyngeal carcinoma in children: Multimodal treatment and long‐term outcome of 92 patients in a single center over a 28‐year period
    Rejin Kebudi, Sema Bay Buyukkapu, Omer Gorgun, Kübra Ozkaya, Rasim Meral, Inci Ayan, Musa Altun
    Pediatric Blood & Cancer.2021;[Epub]     CrossRef
  • Induction or adjuvant chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in paediatric nasopharyngeal carcinoma in the IMRT era: A recursive partitioning risk stratification analysis based on EBV DNA
    Yu-Jing Liang, Dong-Xiang Wen, Mei-Juan Luo, Lin-Quan Tang, Shan-Shan Guo, Pan Wang, Qiu-Yan Chen, Li-Ting Liu, Hai-Qiang Mai
    European Journal of Cancer.2021; 159: 133.     CrossRef
  • Time-to-Event Supervised Genetic Algorithm Enables Induction Chemotherapy Decision Making for Nasopharyngeal Carcinoma
    Demin Liu, Haojiang Li, Liyang Wu, Shuchao Chen, Tianqiao Zhang, Wenjie Huang, Guangying Ruan, Sai Li, Lizhi Liu, Hongbo Chen
    IEEE Access.2021; 9: 98701.     CrossRef
  • LHX2 Facilitates the Progression of Nasopharyngeal Carcinoma via Activation of the FGF1/FGFR Axis
    Tao Xie, Kunpeng Du, Wei Liu, Chunshan Liu, Baiyao Wang, Yunhong Tian, Rong Li, Xiaoting Huang, Jie Lin, Haifeng Jian, Jian Zhang, Yawei Yuan
    SSRN Electronic Journal .2021;[Epub]     CrossRef
  • Prognostic impact of immunohistopathologic features in definitive radiation therapy for nasopharyngeal cancer patients
    Naoya Murakami, Taisuke Mori, Yuko Kubo, Seiichi Yoshimoto, Kimiteru Ito, Yoshitaka Honma, Takao Ueno, Kenya Kobayashi, Hiroyuki Okamoto, Narikazu Boku, Kana Takahashi, Koji Inaba, Kae Okuma, Hiroshi Igaki, Yuko Nakayama, Jun Itami
    Journal of Radiation Research.2020; 61(1): 161.     CrossRef
  • The efficacy and safety of induction chemotherapy combined with concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in nasopharyngeal carcinoma patients: a systematic review and meta-analysis
    Bi-Cheng Wang, Bo-Ya Xiao, Guo-He Lin, Chang Wang, Quentin Liu
    BMC Cancer.2020;[Epub]     CrossRef
  • Update in pediatric nasopharyngeal undifferentiated carcinoma
    Line Claude, Emmanuel Jouglar, Loig Duverge, Daniel Orbach
    The British Journal of Radiology.2019;[Epub]     CrossRef
  • 8,462 View
  • 210 Download
  • 18 Web of Science
  • 14 Crossref
Close layer
Breast Conservation Therapy Versus Mastectomy in Patients with T1-2N1 Triple-Negative Breast Cancer: Pooled Analysis of KROG 14-18 and 14-23
Kyubo Kim, Hae Jin Park, Kyung Hwan Shin, Jin Ho Kim, Doo Ho Choi, Won Park, Seung Do Ahn, Su Ssan Kim, Dae Yong Kim, Tae Hyun Kim, Jin Hee Kim, Jiyoung Kim
Cancer Res Treat. 2018;50(4):1316-1323.   Published online January 8, 2018
DOI: https://doi.org/10.4143/crt.2017.575
AbstractAbstract PDFPubReaderePub
Purpose
The aim of this study is to compare the treatment outcomes of breast conserving surgery (BCS) plus radiotherapy (RT) versus mastectomy for patients with pT1-2N1 triple-negative breast cancer (TNBC).
Materials and Methods
Using two multicenter retrospective studies on breast cancer, a pooled analysis was performed among 320 patients with pT1-2N1 TNBC. All patients who underwent BCS (n=212) receivedwhole breast RTwith orwithoutregional nodal RT,while nonewho underwent mastectomy (n=108)received it. All patients received taxane-based adjuvant chemotherapy. The median follow-up periods were 65 months in the BCS+RT group, and 74 months in the mastectomy group.
Results
The median age of all patients was 48 years (range, 24 to 70 years). Mastectomy group had more patients with multiple tumors (p < 0.001), no lymphovascular invasion (p=0.001), higher number of involved lymph node (p=0.028), and higher nodal ratio ≥ 0.2 (p=0.037). Other characteristics were not significantly different between the two groups. The 5-year locoregionalrecurrence-free, disease-free, and overall survivalrates of BCS+RT group versus mastectomy group were 94.6% versus 87.7%, 89.5% versus 80.4%, and 95.0% versus 87.8%, respectively, and the differences were statistically significant after adjusting for covariates (p=0.010, p=0.006, and p=0.005, respectively).
Conclusion
In pT1-2N1 TNBC, breast conservation therapy achieved better locoregional recurrencefree, disease-free, and overall survival rates compared with mastectomy.

Citations

Citations to this article as recorded by  
  • Breast conserving surgery combined with radiation therapy offers improved survival over mastectomy in early-stage breast cancer
    Elizaveta Vasilyeva, Alan Nichol, Brendan Bakos, Anise Barton, Michelle Goecke, Elaine Lam, Erin Martin, Caroline Lohrisch, Elaine McKevitt
    The American Journal of Surgery.2024; 231: 70.     CrossRef
  • Oncoplastic Breast Conservation for Central Tumors: Definition, Classification, and the Analysis of Single Institution Experience
    Andrii Zhygulin, Artem Fedosov
    Plastic and Reconstructive Surgery - Global Open.2024; 12(5): e5789.     CrossRef
  • Treatment Outcomes after Postoperative Radiotherapy in Triple-Negative Breast Cancer: Multi-Institutional Retrospective Study (KROG 17-05)
    Jin Kim, Sang Byun, Myeongsoo Kim, Kyung Shin, Dong Kim, Han Lee, Tae Kim, Yeon Kim, Yong Kim, Jee Chang, Kyubo Kim, Sun Lee
    Journal of Personalized Medicine.2024; 14(9): 941.     CrossRef
  • Recent Advances in Targeted Nanocarriers for the Management of Triple Negative Breast Cancer
    Rajesh Pradhan, Anuradha Dey, Rajeev Taliyan, Anu Puri, Sanskruti Kharavtekar, Sunil Kumar Dubey
    Pharmaceutics.2023; 15(1): 246.     CrossRef
  • Breast-Conserving Therapy is Associated with Improved Survival Without an Increased Risk of Locoregional Recurrence Compared with Mastectomy in Both Clinically Node-Positive and Node-Negative Breast Cancer Patients
    Elizaveta Vasilyeva, Jeremy Hamm, Alan Nichol, Kathryn V. Isaac, Amy Bazzarelli, Carl Brown, Caroline Lohrisch, Elaine McKevitt
    Annals of Surgical Oncology.2023; 30(11): 6413.     CrossRef
  • Postmastectomy Radiation Therapy in Patients With Minimally Involved Lymph Nodes: A Review of the Current Data and Future Directions
    Bum-Sup Jang, Kyung Hwan Shin
    Journal of Breast Cancer.2022; 25(1): 1.     CrossRef
  • A Review of Current treatment for Triple-Negative Breast Cancer (TNBC)
    Wahyuni Wahyuni, Ajeng Diantini, Mohammad Ghozali, Sahidin I
    Research Journal of Pharmacy and Technology.2022; : 409.     CrossRef
  • Long non-coding RNA MRPS30 divergent transcript can be detected in the cytoplasm of triple-negative breast cancer cells and is targeted by microRNA-130b
    Dongtao Wang, Qiang Song, Tianyong Zhao, Fang Wang, Yang Yu, Jing Qi, Pengfei Lyu, Xiangyang Duan
    Bioengineered.2022; 13(3): 5954.     CrossRef
  • Breast-conserving surgery versus mastectomy for older women with triple-negative breast cancer: population-based study
    Waruiru Mburu, Shalini Kulasingam, James S Hodges, Beth A Virnig
    Journal of Comparative Effectiveness Research.2022; 11(13): 953.     CrossRef
  • Determining prognostic factors and optimal surgical intervention for early-onset triple-negative breast cancer
    Yi-Zi Zheng, Yan Liu, Zhen-Han Deng, Guo-Wen Liu, Ni Xie
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Postoperative Radiotherapy Contributes to the Survival Benefit of Breast-Conserving Therapy over Mastectomy
    Chu-Ying Chen, Si-Yue Zheng, Gang Cai, Cheng Xu, Rong Cai, Min Li, Kun-Wei Shen, Xiao-Song Chen, Dan Ou, Wei-Xiang Qi, Lu Cao, Jia-Yi Chen, Weiren Luo
    Journal of Oncology.2022; 2022: 1.     CrossRef
  • Значення локорегіонарної терапії у хворих на тричі негативний рак грудної залози (огляд літератури)
    M.V. Pavlushenko, R.V. Liubota, R.I. Vereshchako, O.S. Zotov, M.F. Anikusko, I.I. Liubota
    Practical oncology.2022; 5(1): 23.     CrossRef
  • Breast conservation therapy confers survival and distant recurrence advantage over mastectomy for stage II Triple Negative Breast cancer
    Rebekah Macfie, Cynthia Aks, Kathryn Panwala, Nathalie Johnson, Jennifer Garreau
    The American Journal of Surgery.2021; 221(4): 809.     CrossRef
  • Outcomes after breast-conserving surgery or mastectomy in patients with triple-negative breast cancer: meta-analysis
    A Fancellu, N Houssami, V Sanna, A Porcu, C Ninniri, M L Marinovich
    British Journal of Surgery.2021; 108(7): 760.     CrossRef
  • Are the Outcomes of Breast Conservation Surgery Inferior to Those of Mastectomy in Patients with Stage II-IIIA Triple-Negative Breast Cancer?
    Seungju Lee, Hyun Yul Kim, Youn Joo Jung, Hyun-June Paik, Dong-Il Kim, Chang Shin Jung, Seok-Kyung Kang, Jee Yeon Kim, Seokwon Lee, Youngtae Bae
    Journal of Breast Disease.2021; 9(2): 77.     CrossRef
  • Thrombin generation predicts early recurrence in breast cancer patients
    Marina Marchetti, Cinzia Giaccherini, Giovanna Masci, Cristina Verzeroli, Laura Russo, Luigi Celio, Roberta Sarmiento, Sara Gamba, Carmen J. Tartari, Erika Diani, Alfonso Vignoli, Paolo Malighetti, Daniele Spinelli, Nicole M. Kuderer, Federico Nichetti, M
    Journal of Thrombosis and Haemostasis.2020; 18(9): 2220.     CrossRef
  • Molecular Investigation on a Triple Negative Breast Cancer Xenograft Model Exposed to Proton Beams
    Francesco P. Cammarata, Giusi I. Forte, Giuseppe Broggi, Valentina Bravatà, Luigi Minafra, Pietro Pisciotta, Marco Calvaruso, Roberta Tringali, Barbara Tomasello, Filippo Torrisi, Giada Petringa, Giuseppe A. P. Cirrone, Giacomo Cuttone, Rosaria Acquaviva,
    International Journal of Molecular Sciences.2020; 21(17): 6337.     CrossRef
  • Radiotherapy plays an important role in improving the survival outcome in patients with T1–2N1M0 breast cancer – a joint analysis of 4262 real world cases from two institutions
    Guang-Yi Sun, Ge Wen, Yu-Jing Zhang, Yu Tang, Hao Jing, Jian-Yang Wang, Jiang-Hu Zhang, Yong Yang, Xu-Ran Zhao, Si-Ye Chen, Jing Jin, Yong-Wen Song, Yue-Ping Liu, Hui Fang, Hua Ren, Yuan Tang, Shu-Nan Qi, Ning Li, Bo Chen, Ning-Ning Lu, Shu-Lian Wang, Ye-
    BMC Cancer.2020;[Epub]     CrossRef
  • Mastectomy or Breast-Conserving Therapy for Early Breast Cancer in Real-Life Clinical Practice: Outcome Comparison of 7565 Cases
    Stefanie Corradini, Daniel Reitz, Montserrat Pazos, Stephan Schönecker, Michael Braun, Nadia Harbeck, Christiane Matuschek, Edwin Bölke, Ute Ganswindt, Filippo Alongi, Maximilian Niyazi, Claus Belka
    Cancers.2019; 11(2): 160.     CrossRef
  • Are breast conservation treatment rates optimized for Asian women with symptomatic malignancies?
    Mona P. C. Tan, Yih Yiow Sitoh
    ANZ Journal of Surgery.2019; 89(5): 529.     CrossRef
  • 8,766 View
  • 220 Download
  • 16 Web of Science
  • 20 Crossref
Close layer
Multicenter Phase II Study of Oxaliplatin, Irinotecan, and S-1 as First-line Treatment for Patients with Recurrent or Metastatic Biliary Tract Cancer
Changhoon Yoo, Boram Han, Hyeong Su Kim, Kyu-pyo Kim, Deokhoon Kim, Jae Ho Jeong, Jae-Lyun Lee, Tae Won Kim, Jung Han Kim, Dae Ro Choi, Hong Il Ha, Jinwon Seo, Heung-Moon Chang, Baek-Yeol Ryoo, Dae Young Zang
Cancer Res Treat. 2018;50(4):1324-1330.   Published online January 8, 2018
DOI: https://doi.org/10.4143/crt.2017.526
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Although gemcitabine plus cisplatin has been established as the standard first-line chemotherapy for patients with advanced biliary tract cancer (BTC), overall prognosis remains poor. We investigated the efficacy of a novel triplet combination of oxaliplatin, irinotecan, and S-1 (OIS) for advanced BTC.
Materials and Methods
Chemotherapy-naive patientswith histologically documented unresectable or metastatic BTC were eligible for this multicenter, single-arm phase II study. Patients received 65 mg/m2 oxaliplatin (day 1), 135 mg/m2 irinotecan (day 1), and 40 mg/m2 S-1 (twice a day, days 1-7) every 2 weeks. Primary endpoint was objective response rate. Targeted exome sequencing for biomarker analysis was performed using archival tissue.
Results
In total, 32 patients were enrolled between October 2015 and June 2016. Median age was 64 years (range, 40 to 76 years), with 24 (75%) male patients; 97% patients had metastatic or recurrent disease. Response rate was 50%, and median progression-free survival and overall survival (OS) were 6.8 months (95% confidence interval [CI], 4.8 to 8.8) and 12.5 months (95% CI, 7.0 to 18.0), respectively. The most common grade 3-4 adverse events were neutropenia (32%), diarrhea (6%), and peripheral neuropathy (6%). TP53 and KRAS mutations were the most frequent genomic alterations (42% and 32%, respectively), and KRAS mutations showed a marginal relationship with worse OS (p=0.07).
Conclusion
OIS combination chemotherapy was feasible and associated with favorable efficacy outcomes as a first-line treatment in patients with advanced BTC. Randomized studies are needed to compare OIS with gemcitabine plus cisplatin.

Citations

Citations to this article as recorded by  
  • A phase 1 study of biweekly nab-paclitaxel/oxaliplatin/S-1/LV for advanced upper gastrointestinal cancers: TCOG T1216 study
    Hui-Jen Tsai, Shih-Hung Yang, Chin-Fu Hsiao, Hsiang-Fong Kao, Yung-Yeh Su, Yan-Shen Shan, Chia-Jui Yen, Jeng-Shiun Du, Chiun Hsu, I-Chen Wu, Li-Tzong Chen
    The Oncologist.2024; 29(10): e1396.     CrossRef
  • Liposomal irinotecan, oxaliplatin, and S-1 as first-line therapy for patients with locally advanced or metastatic pancreatic adenocarcinoma (NASOX): A multicenter phase I/IIa study
    Hyehyun Jeong, Bum Jun Kim, Choong-kun Lee, Inkeun Park, Dae Young Zang, Hye Jin Choi, Sang Soo Lee, Do Hyun Park, Tae Jun Song, Dongwook Oh, Sung-Hoon Moon, Kyu-pyo Kim, Zev Wainberg, Baek-Yeol Ryoo, Changhoon Yoo
    European Journal of Cancer.2024; 208: 114194.     CrossRef
  • Redox-responsive engineered hybrid nanomedicine for gallbladder cancer therapy via hyaluronic acid depletion
    Jinglin Zou, Cong Jiang, Xianglong Li, Tianyu Zhong, Shuqi Wang, Bo Wang, Dapeng Zhang, Ji-Na Hao, Yuanyuan Cao, Mengjia Guan, Peng Zhang, Bin Dai, Yongsheng Li
    Applied Materials Today.2023; 30: 101707.     CrossRef
  • Optimizing Patient Pathways in Advanced Biliary Tract Cancers: Recent Advances and a French Perspective
    Cindy Neuzillet, Pascal Artru, Eric Assenat, Julien Edeline, Xavier Adhoute, Jean-Christophe Sabourin, Anthony Turpin, Romain Coriat, David Malka
    Targeted Oncology.2023; 18(1): 51.     CrossRef
  • Neoadjuvant Therapy for Extrahepatic Biliary Tract Cancer: A Propensity Score-Matched Survival Analysis
    Junya Toyoda, Kota Sahara, Tomoaki Takahashi, Kentaro Miyake, Yasuhiro Yabushita, Yu Sawada, Yuki Homma, Ryusei Matsuyama, Itaru Endo, Timothy Pawlik
    Journal of Clinical Medicine.2023; 12(7): 2654.     CrossRef
  • Modified FOLFIRINOX Versus CISGEM Chemotherapy for Patients With Advanced Biliary Tract Cancer (PRODIGE 38 AMEBICA): A Randomized Phase II Study
    Jean marc Phelip, Jérôme Desrame, Julien Edeline, Emilie Barbier, Eric Terrebonne, Pierre Michel, Hervé Perrier, Laetitia Dahan, Vincent Bourgeois, Faiza Khemissa Akouz, Emilie Soularue, Valérie Lebrun Ly, Yann Molin, Thierry Lecomte, François Ghiringhell
    Journal of Clinical Oncology.2022; 40(3): 262.     CrossRef
  • Early Recurrence in Resected Gallbladder Carcinoma: Clinical Impact and Its Preoperative Predictive Score
    Yuji Shimizu, Ryo Ashida, Teiichi Sugiura, Yukiyasu Okamura, Katsuhisa Ohgi, Mihoko Yamada, Shimpei Otsuka, Takeshi Aramaki, Akifumi Notsu, Katsuhiko Uesaka
    Annals of Surgical Oncology.2022; 29(9): 5447.     CrossRef
  • Efficacy and safety of modified FOLFIRINOX as salvage therapy for patients with refractory advanced biliary tract cancer: a retrospective study
    Liu-Fang Ye, Chao Ren, Long Bai, Jie-Ying Liang, Ming-Tao Hu, Hui Yang, Zhi-Qiang Wang, Feng-Hua Wang, Rui-Hua Xu, Yu-Hong Li, De-Shen Wang
    Investigational New Drugs.2021; 39(3): 836.     CrossRef
  • Current Status and Future Perspectives of Perioperative Therapy for Resectable Biliary Tract Cancer: A Multidisciplinary Review
    Changhoon Yoo, Sang Hyun Shin, Joon-Oh Park, Kyu-Pyo Kim, Jae Ho Jeong, Baek-Yeol Ryoo, Woohyung Lee, Ki-Byung Song, Dae-Wook Hwang, Jin-hong Park, Jae Hoon Lee
    Cancers.2021; 13(7): 1647.     CrossRef
  • Chemotherapy for advanced gallbladder cancer (GBC): A systematic review and meta-analysis
    Alexander A. Azizi, Angela Lamarca, Mairéad G. McNamara, Juan W. Valle
    Critical Reviews in Oncology/Hematology.2021; 163: 103328.     CrossRef
  • Modified FOLFIRINOX versus gemcitabine plus oxaliplatin as first-line chemotherapy for patients with locally advanced or metastatic cholangiocarcinoma: a retrospective comparative study
    Lu Zou, Xuechuan Li, Xiangsong Wu, Jiujie Cui, Xuya Cui, Xiaoling Song, Tai Ren, Xusheng Han, Yidi Zhu, Huaifeng Li, Wenguang Wu, Xu’an Wang, Wei Gong, Liwei Wang, Maolan Li, Wan Yee Lau, Yingbin Liu
    BMC Cancer.2021;[Epub]     CrossRef
  • A Novel Combination of Bevacizumab with Chemotherapy Improves Therapeutic Effects for Advanced Biliary Tract Cancer: A Retrospective, Observational Study
    Sung-Nan Pei, Chun-Kai Liao, Yaw-Sen Chen, Cheng-Hao Tseng, Chao-Ming Hung, Chong-Chi Chiu, Meng-Che Hsieh, Yu-Fen Tsai, Hsiu-Yun Liao, Wei-Ching Liu, Kun-Ming Rau
    Cancers.2021; 13(15): 3831.     CrossRef
  • Liposomal irinotecan plus fluorouracil and leucovorin versus fluorouracil and leucovorin for metastatic biliary tract cancer after progression on gemcitabine plus cisplatin (NIFTY): a multicentre, open-label, randomised, phase 2b study
    Changhoon Yoo, Kyu-pyo Kim, Jae Ho Jeong, Ilhwan Kim, Myoung Joo Kang, Jaekyung Cheon, Byung Woog Kang, Hyewon Ryu, Ji Sung Lee, Kyung Won Kim, Ghassan K Abou-Alfa, Baek-Yeol Ryoo
    The Lancet Oncology.2021; 22(11): 1560.     CrossRef
  • Efficacy and safety of FOLFIRINOX as salvage treatment in advanced biliary tract cancer: an open-label, single arm, phase 2 trial
    Ali Belkouz, Judith de Vos-Geelen, Ron A. A. Mathôt, Ferry A. L. M. Eskens, Thomas M. van Gulik, Martijn G. H. van Oijen, Cornelis J. A. Punt, Johanna W. Wilmink, Heinz-Josef Klümpen
    British Journal of Cancer.2020; 122(5): 634.     CrossRef
  • miR‐373 inhibits autophagy and further promotes apoptosis of cholangiocarcinoma cells by targeting ULK1
    Pin Lv, Yi‐Fan Luo, Wen‐Yi Zhou, Ben Liu, Zheng Zhou, Yong‐Zhong Shi, Ren Huang, Chuang Peng, Zi‐Li He, Jun Wang, Hong‐Hui Zhang, Sheng‐Dan Nie
    The Kaohsiung Journal of Medical Sciences.2020; 36(6): 429.     CrossRef
  • Advances in adjuvant therapy of biliary tract cancer: an overview of current clinical evidence based on phase II and III trials
    A. Belkouz, J.W. Wilmink, N. Haj Mohammad, J. Hagendoorn, J. de Vos-Geelen, C.H.C. Dejong, M.Y.V. Homs, B. Groot Koerkamp, T.M. van Gulik, M.G.H. van Oijen, C.J.A. Punt, H. Klümpen
    Critical Reviews in Oncology/Hematology.2020; 151: 102975.     CrossRef
  • A retrospective study of patient-tailored FOLFIRINOX as a first-line chemotherapy for patients with advanced biliary tract cancer
    Ayhan Ulusakarya, Abdoulaye Karaboué, Oriana Ciacio, Gabriella Pittau, Mazen Haydar, Pamela Biondani, Yusuf Gumus, Amale Chebib, Wathek Almohamad, Pasquale F. Innominato
    BMC Cancer.2020;[Epub]     CrossRef
  • Overview of current targeted therapy in gallbladder cancer
    Xiaoling Song, Yunping Hu, Yongsheng Li, Rong Shao, Fatao Liu, Yingbin Liu
    Signal Transduction and Targeted Therapy.2020;[Epub]     CrossRef
  • Irinotecan combined with oxaliplatin and S-1 in patients with metastatic pancreatic adenocarcinoma: a single-arm, three-centre, prospective study
    Keke Nie, Ling Zhang, Yunhong You, Hongmei Li, Xiuhui Guo, Zhongfa Zhang, Chunling Zhang, Youxin Ji
    Therapeutic Advances in Medical Oncology.2020;[Epub]     CrossRef
  • The effect of adjuvant chemotherapy in resectable cholangiocarcinoma: A meta-analysis and systematic review
    Ming-Liang Wang, Zhang-Yan Ke, Shuai Yin, Chen-Hai Liu, Qiang Huang
    Hepatobiliary & Pancreatic Diseases International.2019; 18(2): 110.     CrossRef
  • Nal-IRI with 5-fluorouracil (5-FU) and leucovorin or gemcitabine plus cisplatin in advanced biliary tract cancer - the NIFE trial (AIO-YMO HEP-0315) an open label, non-comparative, randomized, multicenter phase II study
    L. Perkhofer, A. W. Berger, A. K. Beutel, E. Gallmeier, S. Angermeier, L. Fischer von Weikersthal, T. O. Goetze, R. Muche, T. Seufferlein, T. J. Ettrich
    BMC Cancer.2019;[Epub]     CrossRef
  • 10,213 View
  • 322 Download
  • 21 Web of Science
  • 21 Crossref
Close layer
High-Dose Metformin Plus Temozolomide Shows Increased Anti-tumor Effects in Glioblastoma In Vitro and In Vivo Compared with Monotherapy
Jung Eun Lee, Ji Hee Lim, Yong Kil Hong, Seung Ho Yang
Cancer Res Treat. 2018;50(4):1331-1342.   Published online January 10, 2018
DOI: https://doi.org/10.4143/crt.2017.466
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The purpose of the study is to investigate the efficacy of combined treatment with temozolomide (TMZ) and metformin for glioblastoma (GBM) in vitro and in vivo.
Materials and Methods
We investigated the efficacy of combined treatment with TMZ and metformin using cell viability and apoptosis assays. A GBM orthotopic mice model was established by inoculation of 5×105 U87 cells and treatedwith metformin, TMZ, and the combination for 4weeks. Western blotting and immunofluorescence of tumor specimens were analyzed to investigate AMP-activated protein kinase (AMPK) and AKT pathway.
Results
The combination of TMZ and metformin showed higher cytotoxicity than single agents in U87, U251, and A172 cell lines. A combination of high-dose metformin and TMZ showed the highest apoptotic activity. The combination of TMZ and metformin enhanced AMPK phosphorylation and inhibited mammalian target of rapamycin phosphorylation, AKT phosphorylation, and p53 expression. The median survival of each group was 43.6, 55.2, 53.2, 65.2, and 71.3 days for control, metformin treatment (2 mg/25 g/day or 10 mg/25 g/day), TMZ treatment (15 mg/kg/day), combination treatment with low-dose metformin and TMZ, and combination treatment with high-dose metformin and TMZ, respectively. Expression of fatty acid synthase (FASN) was significantly decreased in tumor specimens treated with metformin and TMZ.
Conclusion
The combination of metformin and TMZ was superior to monotherapy using metformin or TMZ in terms of cell viability in vitro and survival in vivo. The combination of high-dose metformin and TMZ inhibited FASN expression in an orthotopic model. Inhibition of FASN might be a potential therapeutic target of GBM.

Citations

Citations to this article as recorded by  
  • Survival Impact of Combined Biguanide and Temozolomide in Glioblastoma Preclinical Models: A Systematic Review and Meta-Analysis
    Marcio Yuri Ferreira, Eloísa Bittencurt Thomaz de Assis, Savio Batista, Lucca B. Palavani, Gabriel Verly, Eduardo Mendes Corrêa, Lucas Pari Mitre, Jessica Sales de Oliveira, Raphael Bertani, Daniel Antunes Moreno, Allan Dias Polverini
    World Neurosurgery.2024; 183: 239.     CrossRef
  • Metabolic Contrasts: Fatty Acid Oxidation and Ketone Bodies in Healthy Brains vs. Glioblastoma Multiforme
    Corina Tamas, Flaviu Tamas, Attila Kovecsi, Alina Cehan, Adrian Balasa
    International Journal of Molecular Sciences.2024; 25(10): 5482.     CrossRef
  • Metformin and its potential influence on cell fate decision between apoptosis and senescence in cancer, with a special emphasis on glioblastoma
    Melika Hajimohammadebrahim-Ketabforoush, Alireza Zali, Mohammadreza Shahmohammadi, Amir Ali Hamidieh
    Frontiers in Oncology.2024;[Epub]     CrossRef
  • GBM Cells Exhibit Susceptibility to Metformin Treatment According to TLR4 Pathway Activation and Metabolic and Antioxidant Status
    Isabele Fattori Moretti, Antonio Marcondes Lerario, Paula Rodrigues Sola, Janaína Macedo-da-Silva, Mauricio da Silva Baptista, Giuseppe Palmisano, Sueli Mieko Oba-Shinjo, Suely Kazue Nagahashi Marie
    Cancers.2023; 15(3): 587.     CrossRef
  • Heterogeneity of Amino Acid Profiles of Proneural and Mesenchymal Brain-Tumor Initiating Cells
    Corinna Seliger, Lisa Rauer, Anne-Louise Wüster, Sylvia Moeckel, Verena Leidgens, Birgit Jachnik, Laura-Marie Ammer, Simon Heckscher, Katja Dettmer, Markus Riemenschneider, Peter Oefner, Martin Proescholdt, Arabel Vollmann-Zwerenz, Peter Hau
    International Journal of Molecular Sciences.2023; 24(4): 3199.     CrossRef
  • The Potential Therapeutic Impact of Metformin in Glioblastoma Multiforme
    Mehdi Sanati, Samaneh Aminyavari, Hamid Mollazadeh, Ali Motamed-Sanaye, Bahram Bibak, Elmira Mohtashami, Yong Teng, Amir R. Afshari, Amirhossein Sahebkar
    Current Medicinal Chemistry.2023; 30(7): 857.     CrossRef
  • Development and validation of a GC-MS method for determination of metformin in normal brain and in glioblastoma tissues
    Giorgia Ailuno, Sara Baldassari, Alice Balboni, Giuliana Drava, Cristina Spalletti, Elena Tantillo, Michele Mazzanti, Federica Barbieri, Stefano Thellung, Tullio Florio, Gabriele Caviglioli
    Journal of Pharmaceutical and Biomedical Analysis.2023; 234: 115503.     CrossRef
  • Efficacy and safety of metformin plus low-dose temozolomide in patients with recurrent or refractory glioblastoma: a randomized, prospective, multicenter, double-blind, controlled, phase 2 trial (KNOG-1501 study)
    Wan-Soo Yoon, Jong Hee Chang, Jeong Hoon Kim, Yu Jung Kim, Tae-Young Jung, Heon Yoo, Se-Hyuk Kim, Young-Cho Ko, Do-Hyun Nam, Tae Min Kim, Se Hoon Kim, Sung-Hae Park, Youn Soo Lee, Hyeon Woo Yim, Yong-Kil Hong, Seung Ho Yang
    Discover Oncology.2023;[Epub]     CrossRef
  • Targeted c-Myc Inhibition and Systemic Temozolomide Therapy Extend Survival in Glioblastoma Xenografts
    Laxmi Dhungel, Cayla Harris, Lauren Romine, Jan Sarkaria, Drazen Raucher
    Bioengineering.2023; 10(6): 718.     CrossRef
  • Could Metformin and Resveratrol Support Glioblastoma Treatment? A Mechanistic View at the Cellular Level
    Raghad Sabaawi Ibrahim, Shahad Sabaawi Ibrahim, Ahmed El-Naas, Lenka Koklesová, Peter Kubatka, Dietrich Büsselberg
    Cancers.2023; 15(13): 3368.     CrossRef
  • Dysregulated lipid metabolism in TMZ-resistant glioblastoma: pathways, proteins, metabolites and therapeutic opportunities
    Tzu-Jen Kao, Chien-Liang Lin, Wen-Bin Yang, Hao-Yi Li, Tsung-I Hsu
    Lipids in Health and Disease.2023;[Epub]     CrossRef
  • THERAPEUTIC USE OF METFORMIN IN THYROID CANCER
    Fatimah Haitham Fathi, Ammar A. Y. Almulathanon, Jehan A. Mohammad
    Military Medical Science Letters.2022; 91(4): 348.     CrossRef
  • Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment
    Haksoo Lee, Dahye Kim, BuHyun Youn
    International Journal of Molecular Sciences.2022; 23(22): 13818.     CrossRef
  • Amlexanox Enhances Temozolomide-Induced Antitumor Effects in Human Glioblastoma Cells by Inhibiting IKBKE and the Akt-mTOR Signaling Pathway
    Jinbiao Xiong, Gaochao Guo, Lianmei Guo, Zengguang Wang, Zhijuan Chen, Yang Nan, Yiyao Cao, Ruilong Li, Xuejun Yang, Jun Dong, Xun Jin, Weidong Yang, Qiang Huang
    ACS Omega.2021; 6(6): 4289.     CrossRef
  • Imaging Metformin Efficacy as Add-On Therapy in Cells and Mouse Models of Human EGFR Glioblastoma
    Silvia Valtorta, Alessia Lo Dico, Isabella Raccagni, Cristina Martelli, Valentina Pieri, Paolo Rainone, Sergio Todde, Bastian Zinnhardt, Elisabetta De Bernardi, Angela Coliva, Letterio S. Politi, Thomas Viel, Andreas H. Jacobs, Rossella Galli, Luisa Ottob
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Natural Compounds in Glioblastoma Therapy: Preclinical Insights, Mechanistic Pathways, and Outlook
    Kevin Zhai, Manaal Siddiqui, Basma Abdellatif, Alena Liskova, Peter Kubatka, Dietrich Büsselberg
    Cancers.2021; 13(10): 2317.     CrossRef
  • Role of Polymeric Local Drug Delivery in Multimodal Treatment of Malignant Glioma: A Review
    Yuan-Yun Tseng, Tai-Yuan Chen, Shih-Jung Liu
    International Journal of Nanomedicine.2021; Volume 16: 4597.     CrossRef
  • In Vitro and In Vivo Enhancement of Temozolomide Effect in Human Glioblastoma by Non-Invasive Application of Cold Atmospheric Plasma
    Vikas Soni, Manish Adhikari, Hayk Simonyan, Li Lin, Jonathan H. Sherman, Colin N. Young, Michael Keidar
    Cancers.2021; 13(17): 4485.     CrossRef
  • Landscape of the oncogenic role of fatty acid synthase in human tumors
    Xulei Huo, Lairong Song, Da Li, Ke Wang, Yali Wang, Feng Chen, Liwei Zhang, Liang Wang, Junting Zhang, Zhen Wu
    Aging.2021; 13(23): 25106.     CrossRef
  • Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer
    Sonia A. Allen, Sandipan Datta, Jose Sandoval, Alexey Tomilov, Thomas Sears, Kevin Woolard, James M. Angelastro, Gino A. Cortopassi
    Mitochondrion.2020; 50: 19.     CrossRef
  • Metformin treatment decreases the expression of cancer stem cell marker CD44 and stemness related gene expression in primary oral cancer cells
    Shankargouda Patil
    Archives of Oral Biology.2020; 113: 104710.     CrossRef
  • Metformin Treatment Sensitizes Human Laryngeal Cancer Cell Line Hep- 2 to 5-Fluorouracil
    Neslisah Barlak, Fatma Sanli, Ozel Capik, Elanur Tuysuz, Elanur Aydın Karatas, Hasan Turkez, Omer Faruk Karatas
    Clinical Cancer Drugs.2020; 7(1): 16.     CrossRef
  • An Experimentally Defined Hypoxia Gene Signature in Glioblastoma and Its Modulation by Metformin
    Marta Calvo Tardón, Eliana Marinari, Denis Migliorini, Viviane Bes, Stoyan Tankov, Emily Charrier, Thomas A McKee, Valérie Dutoit, Pierre-Yves Dietrich, Erika Cosset, Paul R Walker
    Biology.2020; 9(9): 264.     CrossRef
  • Repurposing old drugs in oncology: Opportunities with clinical and regulatory challenges ahead
    Rashmi R. Shah, Peter D. Stonier
    Journal of Clinical Pharmacy and Therapeutics.2019; 44(1): 6.     CrossRef
  • Repurposed Biguanide Drugs in Glioblastoma Exert Antiproliferative Effects via the Inhibition of Intracellular Chloride Channel 1 Activity
    Federica Barbieri, Ivan Verduci, Valentina Carlini, Gianluigi Zona, Aldo Pagano, Michele Mazzanti, Tullio Florio
    Frontiers in Oncology.2019;[Epub]     CrossRef
  • DrugR+: A comprehensive relational database for drug repurposing, combination therapy, and replacement therapy
    Yosef Masoudi-Sobhanzadeh, Yadollah Omidi, Massoud Amanlou, Ali Masoudi-Nejad
    Computers in Biology and Medicine.2019; 109: 254.     CrossRef
  • Role of Metformin and AKT Axis Modulation in the Reversion of Hypoxia Induced TMZ-Resistance in Glioma Cells
    Alessia Lo Dico, Silvia Valtorta, Luisa Ottobrini, Rosa Maria Moresco
    Frontiers in Oncology.2019;[Epub]     CrossRef
  • Repurposing drugs for the treatment of glioma
    Chengming Xu, Yaodong Zhao, Congyan Wu, Lei Li
    Glioma.2019; 2(4): 159.     CrossRef
  • Honokiol enhances temozolomide-induced apoptotic insults to malignant glioma cells via an intrinsic mitochondrion-dependent pathway
    Chung-Ching Chio, Yu-Ting Tai, Mahendravarman Mohanraj, Shing-Hwa Liu, Shun-Tai Yang, Ruei-Ming Chen
    Phytomedicine.2018; 49: 41.     CrossRef
  • Pleiotropic Effects of Metformin on Cancer
    Hans-Juergen Schulten
    International Journal of Molecular Sciences.2018; 19(10): 2850.     CrossRef
  • Metformin attenuates cells stemness and epithelial‑mesenchymal transition in colorectal cancer cells by inhibiting the Wnt3a/β‑catenin pathway
    Chu Zhang, Yuchen Wang
    Molecular Medicine Reports.2018;[Epub]     CrossRef
  • 15,505 View
  • 730 Download
  • 31 Web of Science
  • 31 Crossref
Close layer
Trends in Gastric Cancer Incidence According to the Clinicopathological Characteristics in Korea, 1999-2014
Bang Wool Eom, Kyu-Won Jung, Young-Joo Won, Hannah Yang, Young-Woo Kim
Cancer Res Treat. 2018;50(4):1343-1350.   Published online January 15, 2018
DOI: https://doi.org/10.4143/crt.2017.464
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The aim of this study was to evaluate recent trends in gastric cancer incidence according to the age, sex, and tumor location in the Korean population.
Materials and Methods
Using data from the Korea Central Cancer Registry between 1999 and 2014, gastric cancer incidence, annual percent changes, and male-to-female incidence rate ratios (IRRs) according to tumorlocationwere determined. The distribution of disease extent according to the tumor location and its changes between 2006 and 2014 were also analyzed.
Results
Incidence of gastric cancer was stable until 2011 and decreased between 2011 and 2014. The age-standardized incidence rate of gastric cancer was 43.6 (per 100,000) in 1999 and 35.8 in 2014. The proportion of cardia/fundus cancer remained stable (5.9% to 7.1%), and that of body cancer increased (35.3% to 43.2%). The male-to-female IRR decreased in most age groups, except for those in their 60s. In the distribution of disease extent, the proportion of localized disease increased, and regional and distant disease decreased in all tumor locations (53.9% to 66.0%, 31.4% to 22.5%, and 14.8% to 11.5%, respectively; p < 0.001). For histological type, the proportion of carcinoid tumor and non-epithelial tumor increased (0.3% to 1.0%, and 0.8% to 1.4%, respectively).
Conclusion
In the 15 years from 1999 through 2014, age-standardized incidence of gastric cancer started to decrease from 2012, and the proportion of cardia/fundus cancer remained unchanged. The trend of increasing localized cancer was observed in all tumor locations.

Citations

Citations to this article as recorded by  
  • Impact of Smoking and Alcohol Consumption on Early-Onset Gastric Cancer Development in Young Koreans: A Population-Based Study
    Seung Joo Kang, Cheol Min Shin, Kyungdo Han, Jin Hyung Jung, Eun Hyo Jin, Joo Hyun Lim, Yoon Jin Choi, Hyuk Yoon, Young Soo Park, Nayoung Kim, Dong Ho Lee
    Journal of Gastric Cancer.2024; 24(2): 145.     CrossRef
  • Population‐based evaluation of disparities in stomach cancer by nativity among Asian and Hispanic populations in California, 2011–2015
    Eunjung Lee, Kai‐Ya Tsai, Juanjuan Zhang, Amie E. Hwang, Dennis Deapen, Jennifer J. Koh, Eric S. Kawaguchi, James Buxbaum, Sang Hoon Ahn, Lihua Liu
    Cancer.2024; 130(7): 1092.     CrossRef
  • Autoimmune conditions and gastric cancer risk in a population-based study in the United Kingdom
    John D. Murphy, Shahinaz M. Gadalla, Lesley A. Anderson, Charles S. Rabkin, Chris R. Cardwell, Minkyo Song, M. Constanza Camargo
    British Journal of Cancer.2024; 131(1): 138.     CrossRef
  • Long-Term Outcome of Proximal Gastrectomy for Upper-Third Advanced Gastric and Siewert Type II Esophagogastric Junction Cancer Compared With Total Gastrectomy: A Propensity Score-Matched Analysis
    Seungho Lee, Yoon Soo Chae, Won-Gun Yun, Jane Chungyoon Kim, Jae Kyun Park, Min Gyu Kim, Jeesun Kim, Yo-Seok Cho, Seong-Ho Kong, Do Joong Park, Hyuk-Joon Lee, Han-Kwang Yang
    Annals of Surgical Oncology.2024; 31(5): 3024.     CrossRef
  • Risk prediction model for gastric cancer within 5 years in healthy Korean adults
    Hyungseok Oh, Sunwoo Cho, Jung Ah Lee, Seungho Ryu, Yoosoo Chang
    Gastric Cancer.2024; 27(4): 675.     CrossRef
  • Gastric neuroendocrine neoplasms
    Giuseppe Lamberti, Francesco Panzuto, Marianne Pavel, Dermot O’Toole, Valentina Ambrosini, Massimo Falconi, Rocio Garcia-Carbonero, Rachel P. Riechelmann, Guido Rindi, Davide Campana
    Nature Reviews Disease Primers.2024;[Epub]     CrossRef
  • Comparing global trends in gastric cancer and the need for national screening programs: An in-depth literature review
    Aditya Mavinkurve, Mahul Patel, Amanda Shabana, Teesta Das
    Open Health.2024;[Epub]     CrossRef
  • Increasing disparities in the proportions of active treatment and 5-year overall survival over time by age groups among older patients with gastric cancer in Korea
    Hyun-Soo Zhang, Dong-Woo Choi, Han Sang Kim, Hye Jung Kang, Hoyol Jhang, Wonjeong Jeong, Chung Mo Nam, Sohee Park
    Frontiers in Public Health.2023;[Epub]     CrossRef
  • Risk of Gastric Cancer among Patients with Newly Diagnosed Ulcerative Colitis: A Nationwide Population-Based Study
    Hee Man Kim, Jihoon Kim, Hyunil Kim, Soon Chang Park, Jung Kuk Lee, Dae Ryong Kang, Su Young Kim, Hyun-Soo Kim
    Journal of Clinical Medicine.2023; 12(8): 2843.     CrossRef
  • Efficacy of Lymph Node Location-Number Hybrid Staging System on the Prognosis of Gastric Cancer Patients
    Junpeng Wu, Hao Wang, Xin Yin, Xibo Wang, Yufei Wang, Zhanfei Lu, Jiaqi Zhang, Yao Zhang, Yingwei Xue
    Cancers.2023; 15(9): 2659.     CrossRef
  • Genomic differentiation within East Asian Helicobacter pylori
    Yuanhai You, Kaisa Thorell, Lihua He, Koji Yahara, Yoshio Yamaoka, Jeong-Heon Cha, Kazunari Murakami, Yukako Katsura, Ichizo Kobayashi, Daniel Falush, Jianzhong Zhang
    Microbial Genomics .2022;[Epub]     CrossRef
  • Development and external validation of a nomogram for individualized adjuvant imatinib duration for high‐risk gastrointestinal stromal tumors: A multicenter retrospective cohort study
    Ruolin Liu, Yingxin Wu, Jin Gong, Rui Zhao, Li Li, Qianyi Wan, Nan Lian, Xiaoding Shen, Lin Xia, Yuhou Shen, Haitao Xiao, Xiaoting Wu, Yi Chen, Ying Cen, Xuewen Xu
    Cancer Medicine.2022; 11(16): 3093.     CrossRef
  • 20-Year Trends in Detection Rates of Cardia Cancer via Endoscopic Surveillance in Tianjin, China: A Hospital-Based Study
    Rui Wang, Xiaowei Wu, Yan Song, Rui Lin, Zhongqing Zheng, Kui Jiang, Wentian Liu, Min Tang
    Computational and Mathematical Methods in Medicine.2022; 2022: 1.     CrossRef
  • Declining trends of prevalence ofHelicobacter pyloriinfection and incidence of gastric cancer in Taiwan: An updated cross‐sectional survey and meta‐analysis
    Mei‐Jyh Chen, Ming‐Jong Bair, Po‐Yueh Chen, Ji‐Yuh Lee, Tsung‐Hua Yang, Yu‐Jen Fang, Chieh‐Chang Chen, An‐Ti Chang, Wang‐De Hsiao, Jian‐Jyun Yu, Chia‐Chi Kuo, Min‐Chin Chiu, Kun‐Pei Lin, Min‐Horn Tsai, Yao‐Chun Hsu, Chu‐Kuang Chou, Chi‐Yi Chen, Jaw‐Town L
    Helicobacter.2022;[Epub]     CrossRef
  • Epidemiology of Gastric Cancer in Korea: Trends in Incidence and Survival Based on Korea Central Cancer Registry Data (1999–2019)
    Sin Hye Park, Mee Joo Kang, E Hwa Yun, Kyu-Won Jung
    Journal of Gastric Cancer.2022; 22(3): 160.     CrossRef
  • Decreasing Incidence of Gastric Cancer with Increasing Time after Helicobacter pylori Treatment: A Nationwide Population-Based Cohort Study
    Taewan Kim, Seung In Seo, Kyung Joo Lee, Chan Hyuk Park, Tae Jun Kim, Jinseob Kim, Woon Geon Shin
    Antibiotics.2022; 11(8): 1052.     CrossRef
  • Clinicopathological difference between gastric cancer in the lesser curvature and gastric cancer in the greater curvature
    Guo-Cai Li, Hong-Wei Zhang, Hong-Gang Tian, Yun Zhao, Qin-Xian Huang, Ze-Yu Xu, Xiao-Hui Xi, Kai Zhang
    Medicine.2022; 101(33): e29984.     CrossRef
  • Impact of Cardiovascular Diseases on Mortality in Gastric Cancer Patients with Preexisting Chronic Disease
    Kyu-Tae Han, Dong Wook Kim, Woorim Kim
    Yonsei Medical Journal.2022; 63(11): 1043.     CrossRef
  • Long‑term outcome of the endoscopic submucosal dissection of early gastric cancer: A comparison between patients with and without liver cirrhosis
    Seung Kim, Moon Joo, Ah-Young Yoo, Seong Kim, Won Kim, Beom Lee, Jong Park, Hoon Chun, Sang Lee
    Oncology Letters.2022;[Epub]     CrossRef
  • International cost-effectiveness analysis evaluating endoscopic screening for gastric cancer for populations with low and high risk
    Benjamin Ascherman, Aaron Oh, Chin Hur
    Gastric Cancer.2021; 24(4): 878.     CrossRef
  • Impact of Palliative Gastrectomy in Patients with Incurable Gastric Cancer
    Ji Yeon Park, Byunghyuk Yu, Ki Bum Park, Oh Kyoung Kwon, Seung Soo Lee, Ho Young Chung
    Medicina.2021; 57(3): 198.     CrossRef
  • Clinical practice guideline for endoscopic resection of early gastrointestinal cancer
    Chan Hyuk Park, Dong-Hoon Yang, Jong Wook Kim, Jie-Hyun Kim, Ji Hyun Kim, Yang Won Min, Si Hyung Lee, Jung Ho Bae, Hyunsoo Chung, Kee Don Choi, Jun Chul Park, Hyuk Lee, Min-Seob Kwak, Bun Kim, Hyun Jung Lee, Hye Seung Lee, Miyoung Choi, Dong-Ah Park, Jong
    Intestinal Research.2021; 19(2): 127.     CrossRef
  • Oncologic Feasibility of Proximal Gastrectomy in Upper Third Advanced Gastric and Esophagogastric Junctional Cancer
    Won-Gun Yun, Myung-Hoon Lim, Sarah Kim, Sa-Hong Kim, Ji-Hyeon Park, Seong-Ho Kong, Do Joong Park, Hyuk-Joon Lee, Han-Kwang Yang
    Journal of Gastric Cancer.2021; 21(2): 169.     CrossRef
  • Is Splenic Hilar Lymph Node Dissection Without Splenectomy Essential for Proximal Advanced Gastric Cancer?
    Yoon Jung Oh, Deok Hee Kim, Bang Wool Eom, Hong Man Yoon, Young-Woo Kim, Keun Won Ryu
    Annals of Surgical Oncology.2021; 28(13): 8952.     CrossRef
  • Preferences of first-degree relatives of gastric cancer patients for gastric cancer screening: a discrete choice experiment
    Hui-qin Li, Hui Xue, Hua Yuan, Guang-ying Wan, Xiu-ying Zhang
    BMC Cancer.2021;[Epub]     CrossRef
  • Restoration for the foregut surgery: bridging gaps between foregut surgery practice and academia
    Ye-lim Shin, Shin-Hoo Park, Yeongkeun Kwon, Chang Min Lee, Sungsoo Park
    Journal of Minimally Invasive Surgery.2021; 24(4): 175.     CrossRef
  • Prevalence of Regional Lymph Node Metastasis of Mucosal Gastric Signet Ring Cell Carcinoma: Analysis of the Collaborative Stage Data Survey of the Korean Central Cancer Registry
    Seok-Hoo Jeong, Jin Woo Kim, Hee Man Kim
    Digestive Surgery.2021; 38(5-6): 330.     CrossRef
  • Determining the current indications for endoscopic submucosal dissection in patients with Lauren mixed‐type early gastric cancer
    Jinju Choi, Hyunsoo Chung, Jung Kim, Jue Lie Kim, Sang Gyun Kim, Hyun Chae Jung
    Journal of Gastroenterology and Hepatology.2020; 35(4): 586.     CrossRef
  • Effect of histologic differences between biopsy and final resection on treatment outcomes in early gastric cancer
    Yonsoo Kim, Hong Jin Yoon, Jie-Hyun Kim, Jaeyoung Chun, Young Hoon Youn, Hyojin Park, In Gyu Kwon, Seung Ho Choi, Sung Hoon Noh
    Surgical Endoscopy.2020; 34(11): 5046.     CrossRef
  • Nationwide prevalence of potential drug-drug interactions associated with non-anticancer agents in patients on oral anticancer agents in South Korea
    Yun-Kyoung Song, Jung Mi Oh
    Supportive Care in Cancer.2020; 28(8): 3711.     CrossRef
  • Long-term outcomes of patients with gastric adenoma in Korea
    Tae Young Park, Su Jin Jeong, Tae Hyung Kim, Jin Lee, Jongha Park, Tae Oh Kim, Yong Eun Park
    Medicine.2020; 99(12): e19553.     CrossRef
  • Clinical Practice Guideline for Endoscopic Resection of Early Gastrointestinal Cancer
    Chan Hyuk Park, Dong-Hoon Yang, Jong Wook Kim, Jie-Hyun Kim, Ji Hyun Kim, Yang Won Min, Si Hyung Lee, Jung Ho Bae, Hyunsoo Chung, Kee Don Choi, Jun Chul Park, Hyuk Lee, Min-Seob Kwak, Bun Kim, Hyun Jung Lee, Hye Seung Lee, Miyoung Choi, Dong-Ah Park, Jong
    Clinical Endoscopy.2020; 53(2): 142.     CrossRef
  • Current status and trend in training for endoscopic submucosal dissection: A nationwide survey in Korea
    Jae Gon Lee, Chan Hyuk Park, Hyunsoo Chung, Jun Chul Park, Do Hoon Kim, Bo-In Lee, Jeong-Sik Byeon, Hwoon-Yong Jung, Richard Bruce Mink
    PLOS ONE.2020; 15(5): e0232691.     CrossRef
  • The expression of epidermal growth factor receptor 1 and human epidermal growth factor receptor 2 based on tumor location affect survival in gastric cancer
    Guo-Cai Li, Xu-Chun Jia, Qing-Chuan Zhao, Hong-Wei Zhang, Peng Yang, Long-Long Xu, Fang-Ning Pang, Jian-Bing Sun
    Medicine.2020; 99(21): e20460.     CrossRef
  • Clinical Practice Guideline for Endoscopic Resection of Early Gastrointestinal Cancer
    Chan Hyuk Park, Dong-Hoon Yang, Jong Wook Kim, Jie-Hyun Kim, Ji Hyun Kim, Yang Won Min, Si Hyung Lee, Jung Ho Bae, Hyunsoo Chung, Kee Don Choi, Jun Chul Park, Hyuk Lee, Min-Seob Kwak, Bun Kim, Hyun Jung Lee, Hye Seung Lee, Miyoung Choi, Dong-Ah Park, Jong
    The Korean Journal of Gastroenterology.2020; 75(5): 264.     CrossRef
  • Effects of p-coumaric acid on microRNA expression profiles in SNU-16 human gastric cancer cells
    Mi Gyeong Jang, Hee Chul Ko, Se-Jae Kim
    Genes & Genomics.2020; 42(7): 817.     CrossRef
  • Clinical Practice Guideline for Endoscopic Resection of Early Gastrointestinal Cancer
    Chan Hyuk Park, Dong-Hoon Yang, Jong Wook Kim, Jie-Hyun Kim, Ji Hyun Kim, Yang Won Min, Si Hyung Lee, Jung Ho Bae, Hyunsoo Chung, Kee Don Choi, Jun Chul Park, Hyuk Lee, Min-Seob Kwak, Bun Kim, Hyun Jung Lee, Hye Seung Lee, Miyoung Choi, Dong-Ah Park, Jong
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2020; 20(2): 117.     CrossRef
  • Vitamin D Status and Gastric Cancer: A Cross-Sectional Study in Koreans
    Jung Hyun Kwak, Jean Kyung Paik
    Nutrients.2020; 12(7): 2004.     CrossRef
  • The loss of nuclear expression of single-stranded DNA binding protein 2 of gastric adenocarcinoma and its prognostic role: Analysis of molecular subtype
    Seongsik Bang, Hyunsung Kim, Kiseok Jang, Seung Sam Paik, Su-Jin Shin, Valli De Re
    PLOS ONE.2020; 15(8): e0236896.     CrossRef
  • Changing trends of clinicopathologic features and survival duration after surgery for gastric cancer in Northeast China
    Zhao Zhai, Zi-Yu Zhu, Xi-Liang Cong, Bang-Ling Han, Jia-Liang Gao, Xin Yin, Yu Zhang, Sheng-Han Lou, Tian-Yi Fang, Yi-Min Wang, Chun-Feng Li, Xue-Feng Yu, Yan Ma, Ying-Wei Xue
    World Journal of Gastrointestinal Oncology.2020; 12(10): 1119.     CrossRef
  • Endoscopic History and Provider Characteristics Influence Gastric Cancer Survival in Asian Americans
    Christie Y. Jeon, Yu-Chen Lin, Samuel J. Klempner, Bechien U. Wu, Sungjin Kim, Kevin M. Waters, Robert W. Haile
    Cancer Prevention Research.2020; 13(9): 773.     CrossRef
  • Endoscopic Resection of Undifferentiated-type Early Gastric Cancer
    Ayoung Lee, Hyunsoo Chung
    Journal of Gastric Cancer.2020; 20(4): 345.     CrossRef
  • Cycloastragenol can negate constitutive STAT3 activation and promote paclitaxel-induced apoptosis in human gastric cancer cells
    Sun Tae Hwang, Chulwon Kim, Jong Hyun Lee, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Omar H.M. Shair, Gautam Sethi, Kwang Seok Ahn
    Phytomedicine.2019; 59: 152907.     CrossRef
  • Prospective Multicenter Feasibility Study of Laparoscopic Sentinel Basin Dissection after Endoscopic Submucosal Dissection for Early Gastric Cancer: SENORITA 2 Trial Protocol
    Bang Wool Eom, Hong Man Yoon, Jae Seok Min, In Cho, Ji-Ho Park, Mi Ran Jung, Hoon Hur, Young-Woo Kim, Young Kyu Park, Byung-Ho Nam, Keun Won Ryu
    Journal of Gastric Cancer.2019; 19(2): 157.     CrossRef
  • Changes in the Clinical and Pathological Characteristics of Gastric Cancer during the Last 16 Years: A Study of a Single Institution in Korea
    Jung Won Lee, Nayoung Kim, Yong Jae Kwon, Hye Seung Lee
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2019; 19(2): 120.     CrossRef
  • TRP channels in gastric cancer: New hopes and clinical perspectives
    Andra M. Sterea, Emmanuel E. Egom, Yassine El Hiani
    Cell Calcium.2019; 82: 102053.     CrossRef
  • Autoimmune Diseases and Gastric Cancer Risk: A Systematic Review and Meta-Analysis
    Minkyo Song, Gonzalo Latorre, Danisa Ivanovic-Zuvic, M. Constanza Camargo, Charles S. Rabkin
    Cancer Research and Treatment.2019; 51(3): 841.     CrossRef
  • Prognostic Value of Metabolic Information in Advanced Gastric Cancer Using Preoperative 18F-FDG PET/CT
    Hye Ryeong Kwon, Kisoo Pahk, Sungsoo Park, Hyun Woo Kwon, Sungeun Kim
    Nuclear Medicine and Molecular Imaging.2019; 53(6): 386.     CrossRef
  • Development and Validation of an Easy-to-Implement, Practical Algorithm for the Identification of Molecular Subtypes of Gastric Cancer: Prognostic and Therapeutic Implications
    Jiwon Koh, Keun-Wook Lee, Soo Kyung Nam, An Na Seo, Ji-Won Kim, Jin Won Kim, Do Joong Park, Hyung-Ho Kim, Woo Ho Kim, Hye Seung Lee
    The Oncologist.2019; 24(12): e1321.     CrossRef
  • Gastric Cancer: an Evolving Disease
    Minkyo Song, Charles S. Rabkin, M. Constanza Camargo
    Current Treatment Options in Gastroenterology.2018; 16(4): 561.     CrossRef
  • 9,326 View
  • 273 Download
  • 50 Web of Science
  • 50 Crossref
Close layer
Ligand-Independent Epidermal Growth Factor Receptor Overexpression Correlates with Poor Prognosis in Colorectal Cancer
Sumi Yun, Yoonjin Kwak, Soo Kyung Nam, An Na Seo, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Hye Seung Lee
Cancer Res Treat. 2018;50(4):1351-1361.   Published online January 17, 2018
DOI: https://doi.org/10.4143/crt.2017.487
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Molecular treatments targeting epidermal growth factor receptors (EGFRs) are important strategies for advanced colorectal cancer (CRC). However, clinicopathologic implications of EGFRs and EGFR ligand signaling have not been fully evaluated. We evaluated the expression of EGFR ligands and correlation with their receptors, clinicopathologic factors, and patients’ survival with CRC.
Materials and Methods
The expression of EGFR ligands, including heparin binding epidermal growth factor-like growth factor (HBEGF), transforming growth factor (TGF), betacellulin, and epidermal growth factor (EGF), were evaluated in 331 consecutive CRC samples using mRNA in situ hybridization (ISH). We also evaluated the expression status of EGFR, human epidermal growth factor receptor 2 (HER2), HER3, and HER4 using immunohistochemistry and/or silver ISH.
Results
Unlike low incidences of TGF (38.1%), betacellulin (7.9%), and EGF (2.1%), HBEGF expression was noted in 62.2% of CRC samples. However, the expression of each EGFR ligand did not reveal significant correlations with survival. The combined analyses of EGFR ligands and EGFR expression indicated that the ligands‒/EGFR+ group showed a significant association with the worst disease-free survival (DFS; p=0.018) and overall survival (OS; p=0.005). It was also an independent, unfavorable prognostic factor for DFS (p=0.026) and OS (p=0.007). Additionally, HER4 nuclear expression, regardless of ligand expression, was an independent, favorable prognostic factor for DFS (p=0.034) and OS (p=0.049), by multivariate analysis.
Conclusion
Ligand-independent EGFR overexpression was suggested to have a significant prognostic impact; thus, the expression status of EGFR ligands, in addition to EGFR, might be necessary for predicting patients' outcome in CRC.

Citations

Citations to this article as recorded by  
  • Systematic literature review and meta-analysis of HER2 amplification, overexpression, and positivity in colorectal cancer
    Harshabad Singh, Ashley Kang, Lisa Bloudek, Ling-I Hsu, Maria Corinna Palanca-Wessels, Michael Stecher, Muriel Siadak, Kimmie Ng
    JNCI Cancer Spectrum.2024;[Epub]     CrossRef
  • Molecular characterization of colorectal mucinous adenocarcinoma and adenocarcinoma, not otherwise specified, identified by multiomic data analysis
    Kailun Xu, Shu Zheng, Baosheng Li, Yingkuan Shao, Xiaoyang Yin
    Frontiers in Molecular Biosciences.2023;[Epub]     CrossRef
  • Mechanism of 5-fluorouracil nanoparticles on releasing skin squamous cell carcinoma through regulation of Wnt/β-catenin expression
    Lixin Peng, Xinping Zhang, Bin Du, Liangliang Sun, Yuguang Zhao
    Materials Express.2022; 12(2): 220.     CrossRef
  • Research on Anti-Tumor Nano-Particle with New Type 5-Fluorouracil on the Peritoneal Metastasis of Breast Cancer
    Yujie Xiao, Guilin Huang, Yibo Xiang
    Journal of Biomaterials and Tissue Engineering.2021; 11(7): 1277.     CrossRef
  • Growth Factors, PI3K/AKT/mTOR and MAPK Signaling Pathways in Colorectal Cancer Pathogenesis: Where Are We Now?
    Constantin Stefani, Daniela Miricescu, Iulia-Ioana Stanescu-Spinu, Remus Iulian Nica, Maria Greabu, Alexandra Ripszky Totan, Mariana Jinga
    International Journal of Molecular Sciences.2021; 22(19): 10260.     CrossRef
  • SOX2 Promotes Brain Metastasis of Breast Cancer by Upregulating the Expression of FSCN1 and HBEGF
    Weikai Xiao, Shaoquan Zheng, Xinhua Xie, Xing Li, Lijuan Zhang, Anli Yang, Jian Wang, Hailin Tang, Xiaoming Xie
    Molecular Therapy - Oncolytics.2020; 17: 118.     CrossRef
  • Combined Therapeutic Effects of 131I-Labeled and 5Fu-Loaded Multifunctional Nanoparticles in Colorectal Cancer


    Pingping Wu, Huayun Zhu, Yan Zhuang, Xiaofeng Sun, Ning Gu
    International Journal of Nanomedicine.2020; Volume 15: 2777.     CrossRef
  • Enhanced antitumor efficacy in colon cancer using EGF functionalized PLGA nanoparticles loaded with 5-Fluorouracil and perfluorocarbon
    Pingping Wu, Qing Zhou, Huayun Zhu, Yan Zhuang, Jun Bao
    BMC Cancer.2020;[Epub]     CrossRef
  • HER4 promotes the progression of colorectal cancer by promoting epithelial‑mesenchymal transition
    Xiaojing Jia, Huien Wang, Zhongxin Li, Jing Yan, Yan Guo, Wujie Zhao, Lixia Gao, Bin Wang, Yitao Jia
    Molecular Medicine Reports.2020;[Epub]     CrossRef
  • Epidermal Growth Factor Receptor: Key to Selective Intracellular Delivery
    A. A. Rosenkranz, T. A. Slastnikova
    Biochemistry (Moscow).2020; 85(9): 967.     CrossRef
  • Co-expression and prognostic significance of putative CSC markers CD44, CD133, wild-type EGFR and EGFRvIII in metastatic colorectal cancer
    Said Abdullah Khelwatty, Sharadah Essapen, Izhar Bagwan, Margaret Green, Alan M. Seddon, Helmout Modjtahedi
    Oncotarget.2019; 10(18): 1704.     CrossRef
  • 9,342 View
  • 217 Download
  • 12 Web of Science
  • 11 Crossref
Close layer

Cancer Res Treat : Cancer Research and Treatment
Close layer
TOP