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- Volume 50(2); April 2018
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Special Articles
- Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2015
- Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Eun Sook Lee, The Community of Population-Based Regional Cancer Registries
- Cancer Res Treat. 2018;50(2):303-316. Published online March 21, 2018
- DOI: https://doi.org/10.4143/crt.2018.143
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Abstract
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ePub - Purpose
This study presents the 2015 nationwide cancer statistics in Korea, including the incidence, survival, prevalence, and mortality.
Materials and Methods
Cancer incidence data from 1999 to 2015 was obtained from the Korea National Cancer Incidence Database and followed until December 31, 2016. Mortality data from 1983 to 2015 were obtained from Statistics Korea. The prevalence was defined as the number of cancer patients alive on January 1, 2016, among all cancer patients diagnosed since 1999. Crude and age-standardized rates (ASRs) for incidence, mortality and prevalence and 5-year relative survivals were also calculated.
Results
Herein, 214,701 and 76,855 Koreans were newly diagnosed and died from cancer in 2015, respectively. The ASRs for cancer incidence and mortality in 2015 were 258.9 and 82.0 per 100,000, respectively. The overall cancer incidence rate has increased significantly by 3.4% annually from 1999 to 2012, and started to decrease after 2012 (2012-2015, annual percent change, –6.1%). However, the overall cancer mortality has decreased 2.7% annually since 2002. The 5-year relative survival rate for patients diagnosed with cancer between 2011 and 2015 was 70.7%, an improvement from the 41.2% for patients diagnosed between 1993 and 1995.
Conclusion
Age-standardized cancer incidence rates have decreased since 2012 and mortality rates have declined since 2002; however, the 5-year survival rates have improved remarkably from 1993-1995 to 2011-2015 in Korea. -
Citations
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Public Health Nutrition.2020; 23(3): 515. CrossRef - Survival Rate of Prostate Cancer in Asian Countries: A Systematic Review and Meta-Analysis
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Clinical and Experimental Dental Research.2020; 6(1): 90. CrossRef - Analysis of Prognosis according to Type of Health Insurance in Five Major Gastrointestinal Cancer Patients in Public Hospitals: Single-institution Retrospective Study
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Cancers.2020; 12(1): 137. CrossRef - Unexpected Para-aortic Lymph Node Metastasis in Pancreatic Ductal Adenocarcinoma: a Contraindication to Resection?
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Hepatobiliary & Pancreatic Diseases International.2020; 19(6): 575. CrossRef - Evodiamine Mitigates Cellular Growth and Promotes Apoptosis by Targeting the c-Met Pathway in Prostate Cancer Cells
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Molecules.2020; 25(6): 1320. CrossRef - Epstein–Barr virus-encoded miR-BART5-5p upregulates PD-L1 through PIAS3/pSTAT3 modulation, worsening clinical outcomes of PD-L1-positive gastric carcinomas
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Pharmacogenomics and Personalized Medicine.2020; Volume 13: 121. CrossRef- Treatment pattern and overall survival in esophageal cancer during a 13-year period: A nationwide cohort study of 6,354 Korean patients
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Hongjun Yoon, Joohyung Lee, Ji Eun Oh, Hong Rae Kim, Seonhye Lee, Hee Jin Chang, Dae Kyung Sohn
Journal of Digital Imaging.2019; 32(1): 131. CrossRef - Significance of 18F-FDG PET Parameters According to Histologic Subtype in the Treatment Outcome of Stage III Non–small-cell Lung Cancer Undergoing Definitive Concurrent Chemoradiotherapy
Eunji Kim, Hong-Gyun Wu, Bhumsuk Keam, Tae Min Kim, Dong-Wan Kim, Jin Chul Paeng, Hak Jae Kim, Ji Hyun Chang
Clinical Lung Cancer.2019; 20(1): e9. CrossRef - Prognostic factors in patients with metastatic or recurrent pancreatic cancer treated with first-line nab-paclitaxel plus gemcitabine: implication of inflammation-based scores
Inhwan Hwang, Jihoon Kang, Hei Nga Natalie Ip, Jae Ho Jeong, Kyu-pyo Kim, Heung-Moon Chang, Changhoon Yoo, Baek-Yeol Ryoo
Investigational New Drugs.2019; 37(3): 584. CrossRef - Pathologic differential diagnosis of metastatic carcinoma in the liver
Jeong Hwan Park, Jung Ho Kim
Clinical and Molecular Hepatology.2019; 25(1): 12. CrossRef - Synergistic triad epistasis of epigenetic H3K27me modifier genes, EZH2, KDM6A, and KDM6B, in gastric cancer susceptibility
Seon Woo Lee, Do Youn Park, Mi-Young Kim, Changwon Kang
Gastric Cancer.2019; 22(3): 640. CrossRef - Association between dietary cadmium intake and early gastric cancer risk in a Korean population: a case–control study
Hyejin Kim, Jeonghee Lee, Hae Dong Woo, Dong Woo Kim, Il Ju Choi, Young-Il Kim, Jeongseon Kim
European Journal of Nutrition.2019; 58(8): 3255. CrossRef - High Receipt of Statins Reduces the Risk of Lung Cancer in Current Smokers With Hypercholesterolemia: The National Health Insurance Service–Health Screening Cohort
Yu-Jin Kwon, Na-Young You, Jae-Woo Lee, Joungyoun Kim, Hee-Taik Kang
Clinical Lung Cancer.2019; 20(2): e177. CrossRef - Incidence of cervical, endometrial, and ovarian cancer in Korea during 1999–2015
Myong Cheol Lim, Young-Joo Won, Mun Jung Ko, Miseon Kim, Seung-Hyuk Shim, Dong Hoon Suh, Jae-Weon Kim
Journal of Gynecologic Oncology.2019;[Epub] CrossRef - Pregnancy and oncologic outcomes after fertility-sparing management for early stage endometrioid endometrial cancer
Su Hyun Chae, Seung-Hyuk Shim, Sun Joo Lee, Ji Young Lee, Soo-Nyung Kim, Soon-Beom Kang
International Journal of Gynecological Cancer.2019; 29(1): 77. CrossRef - The Risk of Malignancy in Korean Patients with Rheumatoid Arthritis
Hwajeong Lee
Yonsei Medical Journal.2019; 60(2): 223. CrossRef - Clinical Applications of Automated Breast Ultrasound: Screening for Breast Cancer
Sun Mi Kim, Bo La Yun, Mijung Jang
Journal of the Korean Society of Radiology.2019; 80(1): 32. CrossRef - Identification of different gene expressions between diffuse- and intestinal-type spheroid-forming gastric cancer cells
Jong Won Lee, Jae Sook Sung, Young Soo Park, Seok Chung, Yeul Hong Kim
Gastric Cancer.2019; 22(5): 967. CrossRef - Risk of cervical dysplasia among human papillomavirus-infected women in Korea: a multicenter prospective study
Yoon Park, Tae-Jin Kim, Chang-Sun Hwang, Chi Heum Cho, Dae Hoon Jeong, Seok Ju Seong, Jae-Kwan Lee, Sooyoung Hur, Mee-Kyung Kee, Jaehyun Seong, Moran Ki
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Hyeong Su Kim, Jung Han Kim, Boram Han, Dae Ro Choi
Medicina.2019; 55(2): 41. CrossRef - Trends and Outcomes of Non-compliance with Treatment for Gastric Cancer in Korea over the 16 years from 1999 to 2015
Bang Wool Eom, Kyu-Won Jung, Young-Joo Won, Young-Woo Kim
Journal of Gastric Cancer.2019; 19(1): 92. CrossRef - Comparison of the 7th and the 8th AJCC Staging System for Non-metastatic D2-Resected Lymph Node–Positive Gastric Cancer Treated with Different Adjuvant Protocols
Jeong Il Yu, Do Hoon Lim, Jeeyun Lee, Won Ki Kang, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Seung Tae Kim, Su Jin Lee, Sung Kim, Tae Sung Sohn, Jun Ho Lee, Ji Yeong An, Min Gew Choi, Jae Moon Bae, Heejin Yoo, Kyunga Kim
Cancer Research and Treatment.2019; 51(3): 876. CrossRef - Thyroid cancer risks among medical radiation workers in South Korea, 1996–2015
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Environmental Health.2019;[Epub] CrossRef - The role of surgical resection before palliative chemotherapy in advanced gastric cancer
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Scientific Reports.2019;[Epub] CrossRef - How to Achieve a Higher Pathologic Complete Response in Patients With Locally Advanced Rectal Cancer Who Receive Preoperative Chemoradiation Therapy
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Annals of Coloproctology.2019; 35(1): 3. CrossRef - Cancer Survivors and Returning to Work Perspectives from Occupational Health Physicians in Korea
Hye Young Shim, Choong Won Lee, Eun Seung Yu, Bo Young Park, Eun Joo Yang
Journal of Korean Medical Science.2019;[Epub] CrossRef - Risk Factors for Delayed Isolation of Patients with Active Pulmonary Tuberculosis in an Acute-care Hospital
Jaijun Han, Bo Da Nam, Se Yoon Park, Jebyung Park, Eunyoung Lee, Eun Jung Lee, Jung Hwa Hwang, Tae Hyong Kim
Scientific Reports.2019;[Epub] CrossRef - Prognostic impact of persistent lower neutrophil-to-lymphocyte ratio during preoperative chemoradiotherapy in locally advanced rectal cancer patients: A propensity score matching analysis
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PLOS ONE.2019; 14(3): e0214415. CrossRef - Trends and Updated Statistics of Lung Cancer in Korea
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Tuberculosis and Respiratory Diseases.2019; 82(2): 175. CrossRef - Korean Practice Guideline for Gastric Cancer 2018: an Evidence-based, Multi-disciplinary Approach
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Young Jae Kwon, Nayoung Kim, Sung Min Baek, Hye Seung Lee, Jaebong Lee, Young Jae Hwang, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Jin‐Wook Kim, Dong Ho Lee
Helicobacter.2019;[Epub] CrossRef - For Physicians Managing Voiding Dysfunction, Improving the Detection Rate of Early Prostate Cancer and Discrimination From Benign Prostatic Hyperplasia, in a Molecular Biomarker Aspects
Won Tae Kim, Seok Joong Yun, Wun-Jae Kim
International Neurourology Journal.2019; 23(1): 5. CrossRef - Prediagnostic Smoking and Alcohol Drinking and Gastric Cancer Survival: A Korean Prospective Cohort Study
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The Korean Journal of Gastroenterology.2019; 73(3): 141. CrossRef - Role of Upper Gastrointestinal Endoscopy in Patients with Human Immunodeficiency Virus Infection in the Era of Combination Antiretroviral Therapy
Jin Suk Kang, Sun Hee Lee, Shinwon Lee, Gwang Ha Kim, Young Joo Park, In Sub Han, Jeong Eun Lee, Soon Ok Lee, Chisook Moon
Infection & Chemotherapy.2019; 51(1): 35. CrossRef - Lycopene Inhibits Reactive Oxygen Species-Mediated NF-κB Signaling and Induces Apoptosis in Pancreatic Cancer Cells
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Nutrients.2019; 11(4): 762. CrossRef - ΔNp63 to TAp63 expression ratio as a potential molecular marker for cervical cancer prognosis
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PLOS ONE.2019; 14(4): e0214867. CrossRef - A High Visceral-To-Subcutaneous Fat Ratio is an Independent Predictor of Surgical Site Infection after Gastrectomy
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Journal of Clinical Medicine.2019; 8(4): 494. CrossRef - Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2016
Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Eun Sook Lee
Cancer Research and Treatment.2019; 51(2): 417. CrossRef - Prediction of Cancer Incidence and Mortality in Korea, 2019
Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Eun Sook Lee
Cancer Research and Treatment.2019; 51(2): 431. CrossRef - Screening for Lung Cancer Using Low-dose Chest Computed Tomography in Korean Long-term Colorectal Cancer Survivors
Ji Soo Park, Beodeul Kang, Yehyun Park, Soo Jung Park, Jae Hee Cheon, Minkyu Jung, Seung Hoon Beom, Sang Joon Shin, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Kang Young Lee, Joong Bae Ahn, Nam Kyu Kim, Tae Il Kim
Journal of Cancer Prevention.2019; 24(1): 48. CrossRef - Prognostic role of body mass index is different according to menopausal status and tumor subtype in breast cancer patients
Jung Youn Kim, Dae-Won Lee, Kyung-Hun Lee, Ahrum Min, Han Suk Ryu, Han-Byoel Lee, Hyeong-Gon Moon, Tae-Yong Kim, Sae-Won Han, Do-Youn Oh, Wonshik Han, In Ae Park, Dong-Young Noh, Seock-Ah Im, Sukil Kim
Breast Cancer Research and Treatment.2019; 176(2): 453. CrossRef - Sex and Gender Medicine in Pancreatobiliary Diseases
Seon Mee Park
The Korean Journal of Pancreas and Biliary Tract.2019; 24(2): 55. CrossRef - Methylation Signature for Prediction of Progression Free Survival in Surgically Treated Clear Cell Renal Cell Carcinoma
Ho Won Kang, Hongyong Park, Sung Pil Seo, Young Joon Byun, Xuan-Mei Piao, Sung Min Kim, Won Tae Kim, Seok-Joong Yun, Wooyeong Jang, Ho Sun Shon, Keun Ho Ryu, Sang-Cheol Lee, Wun-Jae Kim, Yong-June Kim
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Annals of Coloproctology.2019; 35(2): 83. CrossRef - Small cell lung cancer starting with diabetes mellitus: Two case reports and literature review
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World Journal of Clinical Cases.2019; 7(10): 1213. CrossRef - Different prognosis of patients with esophageal carcinoma with M1a and regional node involvement
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Digestive and Liver Disease.2019; 51(11): 1610. CrossRef - Incidence and Clinical Characteristics of Ischemic Stroke Patients with Underlying Cancer
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Brain & Neurorehabilitation.2019;[Epub] CrossRef - Prevalence of human papillomavirus-related diseases in the Republic of Korea: a cross-sectional study
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Sexually Transmitted Infections.2019; 95(4): 292. CrossRef - Pattern identification of lung cancer patients based on body constitution questionnaires (BCQ) and glycoproteomics for precision medicine
Wonryeon Cho, Ji Hye Kim, Miseon Jeong, Myeong-Sun Kim, Jinwook Lee, Hyoungwoo Son, Chunhoo Cheon, Sunju Park, Seong-Gyu Ko
Medicine.2019; 98(24): e16035. CrossRef - Comparison of Postoperative Pain in Laparoscopy-Assisted Distal Gastrectomy and Totally Laparoscopic Distal Gastrectomy by Location of Mini-Laparotomy Site
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The Journal of Minimally Invasive Surgery.2019; 22(2): 75. CrossRef - Value of Computer Software for Assisting Sonographers in the Diagnosis of Thyroid Imaging Reporting and Data System Grade 3 and 4 Thyroid Space‐Occupying Lesions
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Journal of Ultrasound in Medicine.2019; 38(12): 3291. CrossRef - Mesothelin expression and its prognostic role according to microsatellite instability status in colorectal adenocarcinoma
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Medicine.2019; 98(26): e16207. CrossRef - Cigarette smoking, alcohol consumption, and risk of colorectal cancer in South Korea: A case-control study
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Alcohol.2019; 76: 15. CrossRef - The economic burden of cancers attributable to smoking
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Cancer Research and Treatment.2019; 51(3): 933. CrossRef - Behaviors and Attitudes toward the Use of Complementary and Alternative Medicine among Korean Cancer Patients
Jung Hye Kwon, Sang-Cheol Lee, Myung Ah Lee, Yu Jung Kim, Jung Hun Kang, Jin Young Kim, Hyo Jin Lee, Woo Kyun Bae, Mi-Jung Kim, Eui Kyu Chie, Jin Kim, Yeul Hong Kim, Hyun Cheol Chung, Sun Young Rha
Cancer Research and Treatment.2019; 51(3): 851. CrossRef - Menopausal Symptoms and Quality of Life Among Breast Cancer Patients with Chemotherapy-induced Amenorrhea
Jin-Hee Park, Yong-Sik Jung, Ji Young Kim, Sun Hyoung Bae, Yujung Jo
Asian Oncology Nursing.2019; 19(2): 90. CrossRef - Higher Age Puts Lung Cancer Patients at Risk for Not Receiving Anti-cancer Treatment
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Cancer Research and Treatment.2019; 51(3): 1241. CrossRef - Prevalence and risk factors of colorectal cancer in Asia
Martin CS Wong, Hanyue Ding, Jingxuan Wang, Paul SF Chan, Junjie Huang
Intestinal Research.2019; 17(3): 317. CrossRef - Effects of Acupressure on Fatigue in Patients with Cancer Who Underwent Chemotherapy
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J.W. Lee, K.J. Jung, T.G. Kim, M. Lee, J. Oh, S.H. Jee, M.G. Lee
Journal of the European Academy of Dermatology and Venereology.2019; 33(12): 2296. CrossRef - Malignancy risk in Korean male patients with ankylosing spondylitis
Bora Nam, Hyoungyoung Kim, Eun Jin Jang, Soo-Kyung Cho, Yoon-Kyoung Sung, Tae-Hwan Kim
Rheumatology International.2019; 39(10): 1741. CrossRef - Clinical Implementation of Precision Medicine in Gastric Cancer
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Molecules.2019; 24(16): 2960. CrossRef - Risk of comorbid cardiovascular disease in Korean long‐term cancer survivors
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European Journal of Cancer Care.2019;[Epub] CrossRef - Active and Passive Smoking, BRAFV600E Mutation Status, and the Risk of Papillary Thyroid Cancer: A Large-Scale Case-Control and Case-Only Study
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Cancer Research and Treatment.2019; 51(4): 1392. CrossRef - Current status of stereotactic body radiotherapy for the treatment of hepatocellular carcinoma
Jongmoo Park, Jae Won Park, Min Kyu Kang
Yeungnam University Journal of Medicine.2019; 36(3): 192. CrossRef - Anesthetics and long-term survival after cancer surgery—total intravenous versus volatile anesthesia: a retrospective study
Boohwi Hong, Sunyeul Lee, Yeojung Kim, Minhee Lee, Ann Misun Youn, Hyun Rhim, Seok-Hwan Hong, Yoon-Hee Kim, Seok-Hwa Yoon, Chaeseong Lim
BMC Anesthesiology.2019;[Epub] CrossRef - Development and Effectiveness of an Oncology Nursing Standardized Patient Simulation Program for Nursing Students
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Korean Journal of Adult Nursing.2019; 31(6): 595. CrossRef - The binary presence or absence of lymph node metastasis or extrathyroidal extension is not associated with survival in papillary thyroid cancers: Implications for staging systems
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Cancer Epidemiology.2019; 63: 101589. CrossRef - Genetic Analysis Can Surrogate the Treatment Strategies in Patients with Pancreatic Cancer
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Gut and Liver.2019; 13(6): 587. CrossRef - Diabetes and Cancer: Cancer Should Be Screened in Routine Diabetes Assessment
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Diabetes & Metabolism Journal.2019; 43(6): 733. CrossRef - Gastric Complications after Adjuvant Radiotherapy for Breast Cancer
Won Kyung Cho, Doo Ho Choi, Won Park, Haeyoung Kim, Seonwoo Kim, Myung-Hee Shin, Hyejung Cha
Journal of Breast Cancer.2019; 22(3): 464. CrossRef - The Association between Cancer Screening and Cancer History among Korean Adults: The 2010–2012 Korea National Health and Nutrition Examination Survey
Ye-Seul Kim, Hee-Taik Kang, Jae-Woo Lee
Korean Journal of Family Medicine.2019; 40(5): 307. CrossRef - Prevalence of Women with Dense Breasts in Korea: Results from a Nationwide Cross-sectional Study
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Cancer Research and Treatment.2019; 51(4): 1295. CrossRef - Changing trends in lymphoid neoplasm distribution in South Korea: analysis of 8615 cases from a single institute, 1997–2016
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Medicine.2019; 98(45): e17641. CrossRef - Milk Consumption Decreases Risk for Breast Cancer in Korean Women under 50 Years of Age: Results from the Health Examinees Study
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Nutrients.2019; 12(1): 32. CrossRef - Aerobic capacity correlates with health‐related quality of life after breast cancer surgery
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Annals of Hepato-Biliary-Pancreatic Surgery.2019; 23(4): 319. CrossRef - Induced Tamoxifen Resistance is Mediated by Increased Methylation of E-Cadherin in Estrogen Receptor-Expressing Breast Cancer Cells
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Scientific Reports.2019;[Epub] CrossRef - Evaluation of Commercial Complementary DNA Synthesis Kits for Detecting Human Papillomavirus
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The Korean Journal of Clinical Laboratory Science.2019; 51(3): 309. CrossRef - The epidemiology of hepatitis B virus infection in Korea
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The Korean Journal of Internal Medicine.2019; 34(5): 945. CrossRef - Production and Performance Evaluation of External Quality Assessment Materials for Human Epididymis Protein 4 Assay
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Journal of Laboratory Medicine and Quality Assurance.2019; 41(3): 153. CrossRef - Clinical Implications of Microsatellite Instability in Early Gastric Cancer
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Journal of Gastric Cancer.2019; 19(4): 427. CrossRef - Prognostic Value of Metabolic Information in Advanced Gastric Cancer Using Preoperative 18F-FDG PET/CT
Hye Ryeong Kwon, Kisoo Pahk, Sungsoo Park, Hyun Woo Kwon, Sungeun Kim
Nuclear Medicine and Molecular Imaging.2019; 53(6): 386. CrossRef - Comparison of radiotherapy infrastructure between Korea and Japan
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Japanese Journal of Clinical Oncology.2019; 49(11): 1024. CrossRef - Report of the Korean Association of Lung Cancer Registry (KALC-R), 2014
Chang-Min Choi, Ho Cheol Kim, Chi Young Jung, Deog Gon Cho, Jae Hyun Jeon, Jeong Eun Lee, Jin Seok Ahn, Seung Joon Kim, Yeongdae Kim, Yoo-Duk Choi, Yang-Gun Suh, Jung-Eun Kim, Boram Lee, Young-Joo Won, Young-Chul Kim
Cancer Research and Treatment.2019; 51(4): 1400. CrossRef - Stage 1A Pancreatic Cancer Initially Manifesting as Clinical Acute Pancreatitis
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The Korean Journal of Medicine.2019; 94(6): 519. CrossRef - A Validation Study of a Multiple Reaction Monitoring-Based Proteomic Assay to Diagnose Breast Cancer
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Journal of Breast Cancer.2019; 22(4): 579. CrossRef - Development of Protocol for Korean Lung Cancer Screening Project (K-LUCAS) to Evaluate Effectiveness and Feasibility to Implement National Cancer Screening Program
Jaeho Lee, Juntae Lim, Yeol Kim, Hyae Young Kim, Jin Mo Goo, Choon-Taek Lee, Seung Hun Jang, Won-Chul Lee, Chan Wha Lee, Jin Young An, Ki Dong Ko, Min Ki Lee, Kui Son Choi, Boyoung Park, Duk Hyoung Lee
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Jung Wan Choe, Jong Jin Hyun
The Korean Journal of Gastroenterology.2019; 74(2): 81. CrossRef - Recent Trends in Demographics, Surgery, and Prognosis of Patients with Surgically Resected Lung Cancer in a Single Institution from Korea
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Korean Journal of Women Health Nursing.2019; 25(4): 365. CrossRef - Alcohol consumption and gastric cancer risk in Korea: a case-control study
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- Prediction of Cancer Incidence and Mortality in Korea, 2018
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- Cancer Res Treat. 2018;50(2):317-323. Published online March 21, 2018
- DOI: https://doi.org/10.4143/crt.2018.142
-
Abstract
PDFPubReaderePub
- Purpose
This study aimed to report on cancer incidence and mortality for the year 2018 to estimate Korea’s current cancer burden.
Materials and Methods
Cancer incidence data from 1999 to 2015 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2016 were acquired from Statistics Korea. Cancer incidence and mortality were projected by fitting a linear regression model to observed age-specific cancer rates against observed years, then multiplying the projected age-specific rates by the age-specific population. The Joinpoint regression model was used to determine at which year the linear trend changed significantly, we only used the data of the latest trend.
Results
A total of 204,909 new cancer cases and 82,155 cancer deaths are expected to occur in Korea in 2018. The most common cancer sites were lung, followed by stomach, colorectal, breast and liver. These five cancers represent half of the overall burden of cancer in Korea. For mortality, the most common sites were lung cancer, followed by liver, colorectal, stomach and pancreas.
Conclusion
The incidence rate of all cancer in Korea are estimated to decrease gradually, mainly due to decrease of thyroid cancer. These up-to-date estimates of the cancer burden in Korea could be an important resource for planning and evaluation of cancer-control programs. -
Citations
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Original Articles
- A National Study of Survival Trends and Conditional Survival in Nasopharyngeal Carcinoma: Analysis of the National Population-Based Surveillance Epidemiology and End Results Registry
- Jia-Wei Lv, Xiao-Dan Huang, Yu-Pei Chen, Guan-Qun Zhou, Ling-Long Tang, Yan-Ping Mao, Wen-Fei Li, Ai-Hua Lin, Jun Ma, Ying Sun
- Cancer Res Treat. 2018;50(2):324-334. Published online April 19, 2017
- DOI: https://doi.org/10.4143/crt.2016.544
-
Abstract
PDFPubReaderePub
- Purpose
Conditional survival (CS) provides important information on survival for a period of time after diagnosis. Currently, information on CS patterns of patients with nasopharyngeal carcinoma (NPC) is lacking. We aimed to analyze survival rate over time and estimate CS for NPC patients using a national population-based registry.
Materials and Methods
Patients diagnosed with NPC between 1973 and 2007 with at least 5-year follow-up were identified from the Surveillance Epidemiology End Results registry. Traditional survival rates and crude CS estimateswere calculated using Kaplan-Meier analysis. Risk-adjusted survival curves were plotted from the proportional hazards model using the correct group prognosis method.
Results
For 7,713 patients analyzed, adjusted baseline 5-year overall survival improved significantly from 36.0% in patients diagnosed in 1973-1979, 41.7% in 1980-1989, 46.6% in 1990- 1999, to 54.7% in 2000-2007 (p < 0.01). CS analysis demonstrated that for every additional year survived, adjusted probability of surviving the next 5 years increased from 66.7% (localized), 54.0% (regional), and 35.3% (distant) at the time of diagnosis, to 83.7% (localized), 75.0% (regional), and 62.2% (distant) for patients who had survived 5 years. Adjusted 5-year CS differed among age, sex, tumor histology, ethnicity, and stage subgroups initially, but converged with time.
Conclusion
Treatment outcomes of NPC patients have greatly improved over the decades. Increases in CS become more prominent in patients with distant disease than in those with localized or regional disease as patients survive longer. CS provides more dynamic prognostic information for patients who have survived a period of time after diagnosis. -
Citations
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Annals of Otology, Rhinology & Laryngology.2023; 132(4): 449. CrossRef - Constructing an individualized surveillance framework for nasopharyngeal carcinoma based on a dynamic risk-adapted approach
Tianzhu Lu, Hanchuan Xu, Wanfang Huang, Jingfeng Zong, Caizhu Pan, Chaobin Huang, Youping Xiao, Bijuan Chen, Jingao Li, Jianji Pan, Shaojun Lin, Fang Guo, Qiaojuan Guo
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Jianing Luo, Xiaonan Hu, Xiaofeng Ge
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- Clinical Outcomes of Proton Beam Therapy for Choroidal Melanoma at a Single Institute in Korea
- Tae Wan Kim, Euncheol Choi, Jeonghoon Park, Dong-ho Shin, Su Kyung Jung, Susie Seok, Kwan Ho Cho, Joo-Young Kim, Dae Yong Kim, Tae Hyun Kim, Yang Kwon Suh, Yeon Joo Kim, Sung Ho Moon
- Cancer Res Treat. 2018;50(2):335-344. Published online April 19, 2017
- DOI: https://doi.org/10.4143/crt.2017.070
-
Abstract
PDFPubReaderePub
- Purpose
This study retrospectively evaluated the clinical outcomes and complications of proton beam therapy (PBT) in a single institution in Korea and quantitatively analyzed the change in tumor volume after PBT using magnetic resonance imaging (MRI).
Materials and Methods
Twenty-four treatment-naïve patients who underwent PBT for choroidal melanoma between 2009 and 2015 were reviewed. Dose fractionation was 60-70 cobalt gray equivalents over 5 fractions. Orbital MRIs were taken at baseline and 3, 6, and 12 months after PBT and annually thereafter. The tumor volume was reconstructed and evaluated by stacking the tumor boundary in each thin-sliced axial T1-weighted image using MIM software.
Results
The median follow-up duration was 36.5 months (range, 9 to 82 months). One patient had suspicious local progression and two patients had distant metastasis. The 3-year local progression-free survival, distant metastasis-free survival, and overall survival rates were 95.8%, 95.8%, and 100%,respectively. Five Common Terminology Criteria for Adverse Event ver. 4.03 grade 3-4 toxicities were observed in four patients (16.7%), including one with neovascular glaucoma. The mean tumor volume at the baseline MRI was 0.565±0.084 mL (range, 0.074 to 1.610 mL), and the ratios of the mean volume at 3, 6, and 12 months to that at baseline were 81.8%, 67.3%, and 60.4%, respectively.
Conclusion
The local controlrate and complication profile after PBT in patientswith choroidal melanoma in Korea were comparable with those reported in a previous PBT series. The change in tumor volume after PBT exhibited a gradual regression pattern on MRI. -
Citations
Citations to this article as recorded by- Efficacy and safety of proton radiotherapy in treating choroidal melanoma: a systematic review and meta-analysis
Yuxin Miao, Tingwei Zheng, Qiuning Zhang, Meixuan Li, Qihang Lei, Qin Liu, Hongtao Luo, Huiling Bai
Radiation Oncology.2025;[Epub] CrossRef - Monte Carlo simulation of polymer phantoms in proton therapy for eye tumor treatment
Engin Aşlar, Fatih Ekinci
The European Physical Journal Plus.2025;[Epub] CrossRef - Opportunities and challenges of upright patient positioning in radiotherapy
Lennart Volz, James Korte, Maria Chiara Martire, Ye Zhang, Nicholas Hardcastle, Marco Durante, Tomas Kron, Christian Graeff
Physics in Medicine & Biology.2024; 69(18): 18TR02. CrossRef - Magnetic Resonance Imaging in the Clinical Care for Uveal Melanoma Patients—A Systematic Review from an Ophthalmic Perspective
Myriam G. Jaarsma-Coes, Lisa Klaassen, Marina Marinkovic, Gregorius P. M. Luyten, T. H. Khanh Vu, Teresa A. Ferreira, Jan-Willem M. Beenakker
Cancers.2023; 15(11): 2995. CrossRef - When Is the Optimum Radiological Response to Proton Beam Therapy in Uveal Melanoma?
Matthew Gillam, Glenn Ace Fenech, Oliver Chadwick, Jonathan Nairn, Vikas Chadha, Julie Connolly, Oliver Cram, Wilma Kincaid, Paul Cauchi
Ocular Oncology and Pathology.2023; 9(5-6): 130. CrossRef - Optimization of proton therapy eye-treatment systems toward improved clinical performances
Eustache Gnacadja, Cédric Hernalsteens, Stewart Boogert, Quentin Flandroy, Carolina Fuentes, Laurence J. Nevay, Nicolas Pauly, Eliott Ramoisiaux, William Shields, Robin Tesse, Raphael Van Roermund, Marion Vanwelde
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Kyung Su Kim, Hong-Gyun Wu
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Yong Joon Kim, Christopher Seungkyu Lee, Sung Chul Lee
Journal of Retina.2021; 6(2): 65. CrossRef - Carbon Fiducial Markers for Tumor Localization in Stereotactic Irradiation of Uveal Melanoma
Timothy T. Xu, Jose S. Pulido, Ian F. Parney, Cristiane M. Ida, Lauren A. Dalvin, Timothy W. Olsen
Ocular Oncology and Pathology.2021; 7(5): 368. CrossRef - Uveal Melanoma in Asians: A Review
Pradeep Manchegowda, Arun D. Singh, Carol Shields, Swathi Kaliki, Parag Shah, Lingam Gopal, Pukhraj Rishi
Ocular Oncology and Pathology.2021; 7(3): 159. CrossRef - Preliminary Dosimetric Study of Proton Minibeam Radiation Therapy for the Treatment of Choroidal Melanoma
Myeongsoo Kim, Sang Soo Kim, Haksoo Kim, Sung Ho Moon, Young Kyung Lim, Ui-Jung Hwang, Sang Hyoun Choi
Journal of the Korean Physical Society.2020; 77(5): 447. CrossRef - Visual outcomes of proton beam therapy for choroidal melanoma at a single institute in the Republic of Korea
Su-Kyung Jung, Young-Hoon Park, Dong-ho Shin, Hak-Soo Kim, Jong-Hwi Jung, Tae-Hyun Kim, Sung Ho Moon, Vikas Khetan
PLOS ONE.2020; 15(12): e0242966. CrossRef
- Efficacy and safety of proton radiotherapy in treating choroidal melanoma: a systematic review and meta-analysis
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- The Clinical Utilization of Radiation Therapy in Korea between 2011 and 2015
- Young-Seok Seo, Mi-Sook Kim, Jin-Kyu Kang, Won-Il Jang, Hee Jin Kim, Chul Koo Cho, Hyung Jun Yoo, Eun Kyung Paik, Yu Jin Cha, Jae Sun Yoon
- Cancer Res Treat. 2018;50(2):345-355. Published online April 25, 2017
- DOI: https://doi.org/10.4143/crt.2017.096
-
Abstract
PDFPubReaderePub
- Purpose
The purpose of this study was to estimate the clinical utilization of radiation therapy (RT) in Korea between 2011 and 2015.
Materials and Methods
We analyzed the claims data from the Health Insurance Review and Assessment Service to estimate the clinical utilization of RT. The source population consisted of all patients who had any of the International Classification of Diseases 10th revision cancer diagnoses (C00-C97) and those with diagnostic codes D00-D48, who were also associated with at least one of the procedure codes related to RT.
Results
The total number of patients who received RT in 2011, 2012, 2013, 2014, and 2015 were 54,810, 59,435, 61,839, 64,062, and 66,183, respectively. Among them, the total numbers of male and female patients were 24,946/29,864 in 2011, 27,211/32,224 in 2012, 28,111/33,728 in 2013, 29,312/34,750 in 2014, and 30,266/35,917 in 2015. The utilization rate of RT in cancer patients has also increased steadily over the same period from 25% to 30%. The five cancers that were most frequently treated with RT between 2011 and 2012 were breast, lung, colorectal, liver, and uterine cervical cancers. However, the fifth most common cancer treated with RT that replaced uterine cervical cancer in 2013 was prostate cancer. More than half of cancer patients (64%) were treated with RT in the capital area (Seoul, Gyeonggi, and Incheon).
Conclusion
The total number of patients who underwent RT increased steadily from 2011 to 2015 in Korea. The utilization rate of RT in cancer patients is also increasing. -
Citations
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Rohit Singh Chauhan, Anusheel Munshi, Anirudh Pradhan
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Liuna Bi, Wenjuan Gao, Qian Zhang, Na Li, Xian Zhang, Jing Han
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Kyungmi Yang, Jeong Eun Lee, Won Park, Yong Chan Ahn, Seung Jae Huh
Japanese Journal of Clinical Oncology.2023; 53(12): 1177. CrossRef - An Investigation of the Effect of Virtual Reality on Alleviating Anxiety in Patients With Breast Cancer Undergoing Radiation Therapy: A Randomized Controlled Trial
Jaeyong Shin, Jee Suk Chang, Jin Sung Kim, Ji-Yeon An, Seung Yeun Chung, So-Yeon Yoon, Yong Bae Kim
International Journal of Radiation Oncology*Biology*Physics.2023; 117(5): 1191. CrossRef - Immunomodulatory effect of splenectomy in lung cancer mouse xenograft models receiving radiation therapy
Yeeun Kim, Changhoon Choi, Jee Hyun Park, Won-Gyun Ahn, Sung-Won Shin, Shin-Yeong Kim, Jae Myoung Noh
Radiation Oncology Journal.2022; 40(1): 53. CrossRef - Clinical utilization of radiation therapy in Korea between 2017 and 2019
Eunji Kim, Won Il Jang, Kwangmo Yang, Mi-Sook Kim, Hyung Jun Yoo, Eun Kyung Paik, Heejin Kim, Jaesun Yoon
Radiation Oncology Journal.2022; 40(4): 251. CrossRef - The Effects of Age, Period, and Cohort on the Mortality of Cervical Cancer in Three High‐Income Countries: Canada, Korea, and Italy
Jinyao Wang, Zhiqiang Bai, Xudong Gao, Nianping Zhang, Zhenkun Wang, Zhongjie Shi
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Sunmin Park, Chai Hong Rim, Won Sup Yoon
Radiation Oncology.2021;[Epub] CrossRef - Who Will Benefit from Charged-Particle Therapy?
Kyung Su Kim, Hong-Gyun Wu
Cancer Research and Treatment.2021; 53(3): 621. CrossRef - Current status and comparison of national health insurance systems for advanced radiation technologies in Korea and Japan
Seung Jae Huh, Tetsuo Nishimura, Won Park, Hiroshi Onishi, Yong Chan Ahn, Katsumasa Nakamura
Radiation Oncology Journal.2020; 38(3): 170. CrossRef - External beam radiation therapy in a centenarian with primary liver cancer
Zhen Meng, Feifei Gao, Chang Liu, Shengcai Huang, Kai Hu, Rensheng Wang
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Seung Jae Huh, Tetsuo Nishimura, Won Park, Katsumasa Nakamura
Japanese Journal of Clinical Oncology.2019; 49(11): 1024. CrossRef - Recent trends in intensity-modulated radiation therapy use in Korea
Seung Jae Huh, Won Park, Do Ho Choi
Radiation Oncology Journal.2019; 37(4): 249. CrossRef - Recent clinical applications of external beam radiotherapy for hepatocellular carcinoma according to guidelines, major trials and meta‐analyses
Chai Hong Rim, Hyung Joon Yim, Sunmin Park, Jinsil Seong
Journal of Medical Imaging and Radiation Oncology.2019; 63(6): 812. CrossRef - Second re-irradiation: a narrative review of the available clinical data
Carsten Nieder, Johannes A. Langendijk, Matthias Guckenberger, Anca L. Grosu
Acta Oncologica.2018; 57(3): 305. CrossRef
- An Analysis of Radiotherapy Machine Requirements in India: Impact of the Pandemic and Regional Disparities
- 10,634 View
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- 19 Web of Science
- 15 Crossref
- Omic Approach in Non-smoker Female with Lung Squamous Cell Carcinoma Pinpoints to Germline Susceptibility and Personalized Medicine
- Margherita Baldassarri, Chiara Fallerini, Francesco Cetta, Marco Ghisalberti, Cristiana Bellan, Simone Furini, Ottavia Spiga, Sergio Crispino, Giuseppe Gotti, Francesca Ariani, Piero Paladini, Alessandra Renieri, Elisa Frullanti
- Cancer Res Treat. 2018;50(2):356-365. Published online May 26, 2017
- DOI: https://doi.org/10.4143/crt.2017.125
-
Abstract
PDF
Supplementary MaterialPubReaderePub - Purpose
Lung cancer is strongly associated to tobacco smoking. However, global statistics estimate that in females the proportion of lung cancer cases that is unrelated to tobacco smoking reaches fifty percent, making questionable the etiology of the disease.
Materials and Methods
A never-smoker female with primary EGFR/KRAS/ALK-negative squamous cell carcinoma of the lung and their normal sibswere subjected to a novel integrative “omic” approach using a pedigree-based model for discovering genetic factors leading to cancer in the absence of well-known environmental trigger. A first-stepwhole-exome sequencing on tumor and normal tissue did not identify mutations in known driver genes. Building on the idea of a germline oligogenic origin of lung cancer, we performed whole-exome sequencing of DNA from patients’ peripheral blood and their unaffected sibs. Finally, RNA-sequencing analysis in tumoral and matched non-tumoral tissues was carried out in order to investigate the clonal profile and the pathogenic role of the identified variants.
Results
Filtering for rare variants with Combined Annotation Dependent Depletion (CADD) > 25 and potentially damaging effect, we identified rare/private germline deleterious variants in 11 cancer-associated genes, none ofwhich, except one, sharedwith the healthy sib, pinpointing to a “private” oligogenic germline signature. Noteworthy, among these, two mutated genes, namely ACACA and DEPTOR, turned to be potential targets for therapy because related to known drivers, such as BRCA1 and EGFR.
Conclusion
In the era of precision medicine, this report emphasizes the importance of an “omic” approach to uncover oligogenic germline signature underlying cancer development and to identify suitable therapeutic targets as well. -
Citations
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Open Life Sciences.2023;[Epub] CrossRef - The prognostic value of bone marrow retention index and bone marrow-to-liver ratio of baseline 18F-FDG PET/CT in diffuse large B-cell lymphoma
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European Radiology.2023; 34(4): 2500. CrossRef - MicroRNA‑15a promotes prostate cancer cell ferroptosis by inhibiting GPX4 expression
Po Xu, Ying Wang, Zhe Deng, Zhibo Tan, Xiaojuan Pei
Oncology Letters.2022;[Epub] CrossRef - Prognostic Value of Dual-Time-Point [18F]FDG PET/CT for Predicting Distant Metastasis after Treatment in Patients with Non-Small Cell Lung Cancer
Sang Mi Lee, Jeong Won Lee, Ji-Hyun Lee, In Young Jo, Su Jin Jang
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Julia Krabbe, Thomas Kraus, Hanif Krabbe, Christian Martin, Patrick Ziegler
International Journal of Molecular Sciences.2022; 23(16): 9052. CrossRef - The Challenges of Patient Selection for Prostate Cancer Focal Therapy: A Retrospective Observational Multicentre Study
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Tao Feng, Chunyu Song, Zhiyong Wu, Ke Zhao, Shenglan Ye
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Qingfeng Ye, Jundan Wang, Da Xu, Yu Liu, Dimei Zhang, Jufeng Ye, Hua Li
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Shuangqin Peng, Yanjun Luo, Lijuan Chen, Kang Dai, Qin Wang
Open Medicine.2022; 17(1): 1999. CrossRef - Identification of Urinary Exosomal miRNAs for the Non-Invasive Diagnosis of Prostate Cancer
Zhuo Li, La-Xiu Li, Yan-Jun Diao, Juan Wang, Yun Ye, Xiao-Ke Hao
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Giovanni Cochetti, Alessio Paladini, Jacopo Adolfo Rossi de Vermandois, Sonia Fatigoni, Magda Zanelli, Stefano Ascani, Ettore Mearini
Open Medicine.2021; 16(1): 397. CrossRef - Evaluation of the Predictive Role of Blood-Based Biomarkers in the Context of Suspicious Prostate MRI in Patients Undergoing Prostate Biopsy
Pawel Rajwa, Nicolai A. Huebner, Dadjar I. Hostermann, Nico C. Grossmann, Victor M. Schuettfort, Stephan Korn, Fahad Quhal, Frederik König, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Reza Sari Motlagh, Takafumi Yanagisawa, Abdulmajeed Aydh, Piot
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Francesco Cetta, Alessandra Renieri, Elisa Frullanti
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- Loss of ACOX1 in clear cell renal cell carcinoma and its correlation with clinical features
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- Sub-classification of Advanced-Stage Hepatocellular Carcinoma: A Cohort Study Including 612 Patients Treated with Sorafenib
- Jeong-Ju Yoo, Goh Eun Chung, Jeong-Hoon Lee, Joon Yeul Nam, Young Chang, Jeong Min Lee, Dong Ho Lee, Hwi Young Kim, Eun Ju Cho, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon, Seoul Liver Group
- Cancer Res Treat. 2018;50(2):366-373. Published online May 15, 2017
- DOI: https://doi.org/10.4143/crt.2017.126
-
Abstract
PDFPubReaderePub
- Purpose
Advanced hepatocellular carcinoma (HCC) is associated with various clinical conditions including major vessel invasion, metastasis, and poor performance status. The aim of this study was to establish a prognostic scoring system and to propose a sub-classification of the Barcelona-Clinic Liver Cancer (BCLC) stage C.
Materials and Methods
This retrospective study included consecutive patientswho received sorafenib for BCLC stage C HCC at a single tertiary hospital in Korea. A Cox proportional hazard model was used to develop a scoring system, and internal validationwas performed by a 5-fold cross-validation. The performance of the model in predicting risk was assessed by the area under the curve and the Hosmer-Lemeshow test.
Results
A total of 612 BCLC stage C HCC patients were sub- classified into strata depending on their performance status. Five independent prognostic factors (Child-Pugh score, α-fetoprotein, tumor type, extrahepatic metastasis, and portal vein invasion) were identified and used in the prognostic scoring system. This scoring system showed good discrimination (area under the receiver operating characteristic curve, 0.734 to 0.818) and calibration functions (both p < 0.05 by the Hosmer-Lemeshow test at 1 month and 12 months, respectively). The differences in survival among the different risk groups classified by the total score were significant (p < 0.001 by the log-rank test in both the Eastern Cooperative Oncology Group 0 and 1 strata).
Conclusion
The heterogeneity of patientswith BCLC stage C HCC requires sub-classification of advanced HCC. A prognostic scoring system with five independent factors is useful in predicting the survival of patients with BCLC stage C HCC. -
Citations
Citations to this article as recorded by- Tumor burden affects the progression pattern on the prognosis in patients treated with sorafenib
Jun Sun, Dongdong Xia, Wei Bai, Xiaomei Li, Enxing Wang, ZhanXin Yin, Guohong Han
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Sujin Jin, Won-Mook Choi, Ju Hyun Shim, Danbi Lee, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Jinhong Jung, Sang Min Yoon, Jonggi Choi
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- Interstitial Lung Disease and Lung Cancer Development: A 5-Year Nationwide Population-Based Study
- Won-Il Choi, Sun Hyo Park, Byeong Ju Park, Choong Won Lee
- Cancer Res Treat. 2018;50(2):374-381. Published online May 8, 2017
- DOI: https://doi.org/10.4143/crt.2017.119
-
Abstract
PDFPubReaderePub
- Purpose
In this nationwide 5-year longitudinal population-based study, we aimed at investigating the incidence of lung cancer among patients with interstitial lung disease.
Materials and Methods
Data was collected from the Korean National Health Insurance Research Database from 49,773,195 Korean residents in 2009. Thirteen thousand six hundred and sixty-six patients with interstitial lung disease diagnosed January-December 2009. The end of follow-up was June 30, 2014. Up to four matching chronic obstructive pulmonary disease controls were selected to compare the lung cancer high-risk group based on age, sex, diagnosis date (within 30 days), and hospital size. The number of patients with newly developed lung cancer was determined.
Results
The incidences of lung cancer were 126.98, 156.62, and 370.38 cases per 10,000 person-years (2,732, 809, and 967 cases of cancer, respectively) in the chronic obstructive pulmonary disease, interstitial lung disease, and chronic obstructive pulmonary disease with interstitial lung disease groups, respectively. Of the 879 patients with idiopathic pulmonary fibrosis, 112 developed lung cancer (incidence, 381.00 cases per 10,000 personyears).
Conclusion
Incidence of lung cancer among patients with interstitial lung disease was high. Interstitial lung diseases have a high potential for developing into lung cancer, even when concurrent with chronic obstructive pulmonary disease. -
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- Effect of Necrosis on the miRNA-mRNA Regulatory Network in CRT-MG Human Astroglioma Cells
- So-Hee Ahn, Jung-Hyuck Ahn, Dong-Ryeol Ryu, Jisoo Lee, Min-Sun Cho, Youn-Hee Choi
- Cancer Res Treat. 2018;50(2):382-397. Published online May 22, 2017
- DOI: https://doi.org/10.4143/crt.2016.551
-
Abstract
PDFPubReaderePub
- Purpose
Glioblastoma multiforme (GBM) is the most common adult primary intracranial tumor. The remarkable features of GBM include central necrosis. MicroRNAs (miRNAs) have been considered as diagnostic/prognostic biomarkers for many cancers, including glioblastoma. However, the effect of necrosis on the miRNA expression profile and predicted miRNA-mRNA regulatory information remain unclear. The purpose of this study is to examine the effect of necrotic cells on the modulation of miRNA and mRNA expression profiles and miRNA-mRNA network in CRT-MG cells.
Materials and Methods
We used human astroglioma cells, CRT-MG, treated with necrotic CRT-MG cells to examine the effect of necrosis on the modulation of miRNA and mRNA by next-generation sequencing. For preparation of necrotic cells, CRT-MGcellswere frozen and thawed through cycle of liquid nitrogen–water bath. The putative miRNA-mRNA regulatory relationshipwas inferred through target information, using miRDB.
Results
The necrotic cells induced dysregulation of 106 miRNAs and 887 mRNAs. Among them, 11 miRNAs that had a negative correlation value of p < 0.05 by the hypergeometric test were screened, and their target mRNAs were analyzed by Gene Ontology enrichment analysis. Using the Kyoto Encyclopedia of Genes and Genomes database, we also found several necrotic cell treatment-activated pathways that were modulated by relevant gene targets of differentially expressed miRNAs.
Conclusion
Our result demonstrated that dysregulation of miRNA and mRNA expression profiles occurs when GBM cells are exposed to necrotic cells, suggesting that several miRNAs may have the potential to be used as biomarkers for predicting GBM progression and pathogenesis. -
Citations
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Aida Alizamir, Mohammad Amin Amini, Ashkan Karbasi, Mehdi Beyrami
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Yuanyuan Zhao, Gang Ye, You Wang, Dan Luo
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Xingsong Li, Xiaokang Yu, Yuting He, Yuhuan Meng, Jinsheng Liang, Lizhen Huang, Hongli Du, Xueping Wang, Wanli Liu
BioMed Research International.2018; 2018: 1. CrossRef
- MiR-4492, a New Potential MicroRNA for Cancer Diagnosis and Treatment: A Mini Review
- 10,925 View
- 201 Download
- 7 Web of Science
- 8 Crossref
- TAK-264 (MLN0264) in Previously Treated Asian Patients with Advanced Gastrointestinal Carcinoma Expressing Guanylyl Cyclase C: Results from an Open-Label, Non-randomized Phase 1 Study
- Yung-Jue Bang, Toshimi Takano, Chia-Chi Lin, Adedigbo Fasanmade, Huyuan Yang, Hadi Danaee, Takayuki Asato, Thea Kalebic, Hui Wang, Toshihiko Doi
- Cancer Res Treat. 2018;50(2):398-404. Published online May 10, 2017
- DOI: https://doi.org/10.4143/crt.2017.074
-
Abstract
PDFPubReaderePub
- Purpose
This phase 1 dose-escalation portion of the study evaluated the safety, pharmacokinetics (PK), and antitumor activity of TAK-264 in Asian patients with advanced gastrointestinal (GI) carcinoma or metastatic or recurrent gastric or gastroesophageal junction adenocarcinoma expressing guanylyl cyclase C (GCC).
Materials and Methods
Adult patients with advanced GI malignancies expressing GCC (H-score ≥ 10) received TAK-264 on day 1 of 3-week cycles as 30-minute intravenous infusions for up to 1 year or until disease progression or unacceptable toxicity. The primary objectives were to evaluate the safety profile including dose-limiting toxicities (DLTs) during cycle 1, determine the maximum tolerated dose (MTD), and characterize the PK profile of TAK-264.
Results
Twelve patients were enrolled and treated with 1.2 mg/kg (n=3), 1.5 mg/kg (n=3), or 1.8 mg/kg TAK-264 (n=6). Median number of treatment cycles received was two (range, 1 to 10). None of the patients experienced a DLT and the MTD was not determined. Ten patients (83%) experienced adverse events (AEs). The most common were neutropenia, anorexia, and nausea (each reported by four patients). Five patients (42%) experienced grade ≥ 3 AEs consisting of tumor hemorrhage and hypertension, ascites, adrenal insufficiency, neutropenia and asthenia. Serum exposure to TAK-264 increased proportionally with the dose and the median half-life was approximately 5.5-6.6 days. No patients experienced an objective response.
Conclusion
TAK-264 demonstrated a manageable safety profile with limited antitumor activity consistent with studies conducted in Western patients with advanced GI malignancies. TAK-264 exposure increased proportionally with the dose. -
Citations
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P. Ntellas, A. Athauda, K. Sugiyama, M.L. Le, V. Crespi, I. Chau
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Jia-Lin Hao, Xin-Yun Li, Yu-Tong Liu, Ji-Xuan Lang, Di-Jie Liu, Chun-Dong Zhang
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Karthik Venkatakrishnan, Neeraj Gupta, Patrick F. Smith, Tiffany Lin, Neil Lineberry, Tatiana Ishida, Lin Wang, Mark Rogge
Clinical Pharmacology & Therapeutics.2023; 113(2): 298. CrossRef - A phase I, first-in-human study of TAK-164, an antibody–drug conjugate, in patients with advanced gastrointestinal cancers expressing guanylyl cyclase C
Richard Kim, Alexis D. Leal, Aparna Parikh, David P. Ryan, Shining Wang, Brittany Bahamon, Neeraj Gupta, Aaron Moss, Joanna Pye, Harry Miao, Haig Inguilizian, James M. Cleary
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Moein Piroozkhah, Ali Aghajani, Pooya Jalali, Arvin Shahmoradi, Mobin Piroozkhah, Younes Tadlili, Zahra Salehi
Frontiers in Oncology.2023;[Epub] CrossRef - Antibody-drug conjugates: Resurgent anticancer agents with multi-targeted therapeutic potential
Claudia Ceci, Pedro Miguel Lacal, Grazia Graziani
Pharmacology & Therapeutics.2022; 236: 108106. CrossRef - Research Progress of Antibody–Drug Conjugate Therapy for Advanced Gastric Cancer
Na Wang, Qingyun Mei, Ziwei Wang, Lu Zhao, Dou Zhang, Dongying Liao, Jinhui Zuo, Hongxia Xie, Yingjie Jia, Fanming Kong
Frontiers in Oncology.2022;[Epub] CrossRef - Antibody drug conjugates in gastrointestinal cancer: From lab to clinical development
Davinder Singh, Divya Dheer, Abhilash Samykutty, Ravi Shankar
Journal of Controlled Release.2021; 340: 1. CrossRef
- Expanding the potential of antibody–drug conjugates in gastrointestinal malignancies: beyond HER2 targets
- 9,765 View
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- Development and Evaluation of a Korean Version of a Thyroid-Specific Quality-of-Life Questionnaire Scale in Thyroid Cancer Patients
- Chang Hwan Ryu, Boram Park, Junsun Ryu, Youn Mi Ryu, Seong Ae Jo, You Jin Lee, Eun-Kyung Lee, Yul Hwangbo, Jungnam Joo, Yuh-Seog Jung
- Cancer Res Treat. 2018;50(2):405-415. Published online May 26, 2017
- DOI: https://doi.org/10.4143/crt.2017.012
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
The purpose of this study was to develop a Korean version of the self-reported thyroid-specific quality of life (QoL) questionnaire for thyroid cancer patients (KT-QoL), and to evaluate its reliability and validity.
Materials and Methods
Two hundred seventy-two patients who underwent thyroidectomy from January to December 2010 were recruited in this study. The original version of the thyroid QoL was translated into Korean and evaluated for its reliability and validity. Using the developed KT-QoL, the postoperative QoL was evaluated until postoperative 1 year.
Results
At the preoperative baseline, the item internal consistency (IIC) ranged from ‒0.19 to 0.76, with low IIC values for items 2, 17, and 27. Item discriminant validity ranged from 86% to 97%. These values were similar at the postoperative periods. The internal consistency reliability (Cronbach’s α) was high for all dimensions, ranging from 0.90 to 0.95. The test-retest reliability (intraclass correlation coefficient) was acceptable (0.74-0.82). The external validity examined by the correlation between the item 1j (voice changes) of KT-QoL and the voice handicap index-30 ranged from 0.51 to 0.75. Patients’ QoL scores decreased after surgery, which demonstrated the sensitivity of the questionnaire. The QoL scores in patients with lobectomy showed best QoL scores postoperatively and those with receiving radioactive iodine still showed decreased QoL scores along the postoperative periods.
Conclusion
These results demonstrate that KT-QoL is a valid instrument for evaluating QoL of Korean patients with thyroid cancer. -
Citations
Citations to this article as recorded by- Laryngeal Electromyography as a Predictive Factor in the Evolution of Unilateral Recurrent Paralysis Post-Thyroidectomy
Shirley Tarabichi, Codrut Sarafoleanu
Journal of Clinical Medicine.2025; 14(4): 1047. CrossRef - Health-Related Quality of Life in Patients with Low-Risk Differentiated Thyroid Cancer: A Systematic Review Examining the Extent of Thyroidectomy
Kathy Bach, Palvishey Ansari, Hamayail Ansari, Nicole M. Mott, Dawn M. Elfenbein, Hunter Underwood, Susan C. Pitt
Thyroid®.2024; 34(1): 14. CrossRef - Longitudinal Changes in Quality of Life Before and After Thyroidectomy in Patients With Differentiated Thyroid Cancer
Byung Hun Kim, Soo Rack Ryu, Jin Won Lee, Chang Myeon Song, Yong Bae Ji, Seok Hyun Cho, Seung Hwan Lee, Kyung Tae
The Journal of Clinical Endocrinology & Metabolism.2024; 109(6): 1505. CrossRef - Effect of thyroid-stimulating hormone suppression on quality of life in thyroid lobectomy patients: interim analysis of a multicenter, randomized controlled trial in low- to intermediate-risk thyroid cancer patients (MASTER study)
Ja Kyung Lee, Eu Jeong Ku, Su-jin Kim, Woochul Kim, Jae Won Cho, Kyong Yeun Jung, Hyeong Won Yu, Yea Eun Kang, Mijin Kim, Hee Kyung Kim, Junsun Ryu, June Young Choi
Annals of Surgical Treatment and Research.2024; 106(1): 19. CrossRef - Five-Year Follow-Up of Health-Related Quality of Life in Differentiated Thyroid Cancer Patients Treated with Total Thyroidectomy and Radioiodine in Sweden: A Nationwide Prospective Cohort Study
Julia Winter, Erland Axelsson, Linda Björkhem-Bergman, Catharina Ihre Lundgren, Christel Hedman
Thyroid®.2024; 34(6): 713. CrossRef - Assessment of preoperative health-related quality of life in patients undergoing thyroidectomy based on patient-reported outcomes
Lei Liu, Yuqing Xiang, Lujing Xiong, Chao Li, Wei Dai, Jinchuan Hu, Chunyan Shui, Yuqiu Zhou, Xu Wang, Linjie Ma, Nan Xu, Bintao Hu, Yongcong Cai
Frontiers in Psychology.2024;[Epub] CrossRef - A Prospective Clinical Trial of Radiofrequency Ablation in Patients with Low-Risk Unifocal Papillary Thyroid Microcarcinoma Favoring Active Surveillance Over Surgery
Ji Ye Lee, Dong Gyu Na, Jung Suk Sim, Jin Yong Sung, Sun Wook Cho, Do Joon Park, Young Joo Park, Ji-hoon Kim
Thyroid®.2024; 34(9): 1126. CrossRef - Comparison of Patient-Reported Outcomes Between Active Surveillance and Immediate Lobectomy in Patients with Low-Risk Papillary Thyroid Microcarcinoma: Initial Findings from the KoMPASS Cohort
Min Joo Kim, Hojeong Won, Won Bae Kim, Eun Kyung Lee, Chang Yoon Lee, Sun Wook Cho, Han-Sang Baek, Yong Sang Lee, Yea Eun Kang, Sun Wook Kim, Ho-Cheol Kang, Jeongmin Lee, Mijin Kim, Min Ji Jeon, Jae Hoon Moon
Thyroid®.2024; 34(11): 1371. CrossRef - Optimizing surgical outcomes in papillary thyroid carcinoma with Hashimoto’s Thyroiditis: a retrospective comparative study of unilateral and total thyroidectomy
Xiaoyong Wen, Shiwei Zhou, Wu Li, Hui Li, Xiaohua Song, Yu Mao, Zeyu Li, Guangji Chen, Xiaowei Peng, Peng Wu
Scientific Reports.2024;[Epub] CrossRef - Quality of life in thyroid cancer
Torquil Watt, Thea Christoffersen, Mathilde Borring Brogaard, Jakob Bue Bjorner, Jens Bentzen, Christoffer Holst Hahn, Birte Nygaard, Ulla Feldt-Rasmussen
Best Practice & Research Clinical Endocrinology & Metabolism.2023; 37(1): 101732. CrossRef - Systematic review of health-related quality of life following thyroid cancer
Emma G Walshaw, Mike Smith, Dae Kim, Jonathan Wadsley, Anastasios Kanatas, Simon N. Rogers
Tumori Journal.2022; 108(4): 291. CrossRef - Factors affecting the health-promoting behavior of thyroid cancer survivors: comparison by stage of cancer survivorship
Kyung Ah Park, Sanghee Kim, Eui Geum Oh, Heejung Kim, Hang-Seok Chang, Soo Hyun Kim
Supportive Care in Cancer.2022; 30(4): 3429. CrossRef - Care and Management of Voice Change in Thyroid Surgery: Korean Society of Laryngology, Phoniatrics and Logopedics Clinical Practice Guideline
Chang Hwan Ryu, Seung Jin Lee, Jae-Gu Cho, Ik Joon Choi, Yoon Seok Choi, Yong Tae Hong, Soo Yeon Jung, Ji Won Kim, Doh Young Lee, Dong Kun Lee, GIljoon Lee, Sang Joon Lee, Young Chan Lee, Yong Sang Lee, Inn Chul Nam, Ki Nam Park, Young Min Park, Eui-Suk S
Clinical and Experimental Otorhinolaryngology.2022; 15(1): 24. CrossRef - Health-Related Quality of Life following Total Thyroidectomy and Lobectomy for Differentiated Thyroid Carcinoma: A Systematic Review
Vivianne Landry, Elizabeth Siciliani, Melissa Henry, Richard J. Payne
Current Oncology.2022; 29(7): 4386. CrossRef - Effect of radioiodine therapy under thyroid hormone withdrawal on health-related quality of life in patients with differentiated thyroid cancer
Hui Ming, Hui Yu, Yangbao Liu, Lihua Yang, Yuanhao Chen
Japanese Journal of Clinical Oncology.2022;[Epub] CrossRef - Thyroid disease‐specific quality of life questionnaires ‐ A systematic review
Verena Uslar, Caroline Becker, Dirk Weyhe, Navid Tabriz
Endocrinology, Diabetes & Metabolism.2022;[Epub] CrossRef - Effect of Initial Treatment Choice on 2-year Quality of Life in Patients with Low-risk Papillary Thyroid Microcarcinoma
Jae Hoon Moon, Chang Hwan Ryu, Sun Wook Cho, June Young Choi, Eun-Jae Chung, Jeong Hun Hah, Yul Hwangbo, Woo-Jin Jeong, Yuh-Seog Jung, Ji-hoon Kim, Min Joo Kim, Su-jin Kim, Yeo Koon Kim, Chang Yoon Lee, Eun Kyung Lee, Ji Ye Lee, Kyu Eun Lee, You Jin Lee,
The Journal of Clinical Endocrinology & Metabolism.2021; 106(3): 724. CrossRef - Singing voice range profile: New objective evaluation methods for voice change after thyroidectomy
Jungirl Seok, Youn Mi Ryu, Seong Ae Jo, Chang Yoon Lee, Yuh‐Seog Jung, Junsun Ryu, Chang Hwan Ryu
Clinical Otolaryngology.2021; 46(2): 332. CrossRef - A Propensity Score Matching Study Between Microwave Ablation and Radiofrequency Ablation in Terms of Safety and Efficacy for Benign Thyroid Nodules Treatment
Hao Jin, Jinrui Fan, Ligong Lu, Min Cui
Frontiers in Endocrinology.2021;[Epub] CrossRef - Adaptation transculturelle en Français du questionnaire évaluant la qualité de vie des patients opérés d’un cancer de la thyroïde : THYCA-QoL
Boris Scheller, Joseph Santini, Amélie Anota, Gilles Poissonnet, Y. Chateau, Renaud Schiappa, Danielle Benisvy, Olivier Dassonville, Alexandre Bozec, Emmanuel Chamorey
Bulletin du Cancer.2021; 108(7-8): 696. CrossRef - A Phase II Multi-Center, Non-Randomized, Parallel Group, Non-Inferiority Study to Compare the Efficacy of No Radioactive Iodine Remnant Ablation to Remnant Ablation Treatment in Low- to Intermediate-Risk of Papillary Thyroid Cancer: The MOREthyroid Trial
Eun Kyung Lee, You Jin Lee, Young Joo Park, Jae Hoon Moon, Ka Hee Yi, Koon Soon Kim, Joo Hee Lee, Sun Wook Cho, Jungnam Joo, Yul Hwangbo, Sujeong Go, Do Joon Park
Endocrinology and Metabolism.2020; 35(3): 571. CrossRef - Evaluation of Quality of Life in Patients with Differentiated Thyroid Cancer by Means of the Thyroid-Specific Patient-Reported Outcome Questionnaire: A 5-Year Longitudinal Study
Massimo Giusti, Stefano Gay, Lucia Conte, Francesca Cecoli, Lorenzo Mortara, Lara Vera, Eleonora Monti
European Thyroid Journal.2020; 9(5): 247. CrossRef - Longitudinal Assessment of Quality of Life According to Treatment Options in Low-Risk Papillary Thyroid Microcarcinoma Patients: Active Surveillance or Immediate Surgery (Interim Analysis of MAeSTro)
Sung Hye Kong, Junsun Ryu, Min Joo Kim, Sun Wook Cho, Young Shin Song, Ka Hee Yi, Do Joon Park, Yul Hwangbo, You Jin Lee, Kyu Eun Lee, Su-jin Kim, Woo-Jin Jeong, Eun-Jae Chung, Jeong Hun Hah, June Young Choi, Chang Hwan Ryu, Yuh-Seog Jung, Jae Hoon Moon,
Thyroid.2019; 29(8): 1089. CrossRef - Study Protocol of Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro)
Jae Hoon Moon, Ji-hoon Kim, Eun Kyung Lee, Kyu Eun Lee, Sung Hye Kong, Yeo Koon Kim, Woo-jin Jung, Chang Yoon Lee, Roh-Eul Yoo, Yul Hwangbo, Young Shin Song, Min Joo Kim, Sun Wook Cho, Su-jin Kim, Eun Jae Jung, June Young Choi, Chang Hwan Ryu, You Jin Lee
Endocrinology and Metabolism.2018; 33(2): 278. CrossRef
- Laryngeal Electromyography as a Predictive Factor in the Evolution of Unilateral Recurrent Paralysis Post-Thyroidectomy
- 17,491 View
- 333 Download
- 25 Web of Science
- 24 Crossref
- Stages of Adoption for Fecal Occult Blood Test and Colonoscopy Tests for Colorectal Cancer Screening in Korea
- Nhung Cam Bui, Ha Na Cho, Yoon Young Lee, Mina Suh, Boyoung Park, Jae Kwan Jun, Yeol Kim, Kui Son Choi
- Cancer Res Treat. 2018;50(2):416-427. Published online May 10, 2017
- DOI: https://doi.org/10.4143/crt.2017.075
-
Abstract
PDFPubReaderePub
- Purpose
While colorectal cancer (CRC) is common in Asian countries, screening for CRC is not. Moreover, CRC screening behaviors in Asian populations remain largely unknown. The present study aimed to investigate the stages of adopting CRC screening in Korea according to screening modality.
Materials and Methods
Data were obtained from the 2014 Korean National Cancer Screening Survey, a cross-sectional survey that utilized nationally representative random sampling to investigate cancer screening rates. A total of 2,066 participants aged 50-74 years were included in this study. Chi-square test and multinomial logistic regressionwere applied to determine stages of adoption for fecal occult blood test (FOBT) and colonoscopy and factors associated with each stage.
Results
Of 1,593 participants included in an analysis of stage of adoption for FOBT, 36% were in action/maintenance stages, while 18%, 40%, and 6% were in precontemplation, contemplation, and relapse/relapse risk stages, respectively. Of 1,371 subjects included in an analysis of stage of adoption for colonoscopy, 48% were in action/maintenance stages, with 21% in precontemplation, 21% in contemplation, and 11% in relapse/relapse risk stages. Multinomial logistic regression highlighted sex, household income, place of residency, family history of cancer, having private cancer insurance, smoking status, alcohol use, and regular exercise as being associated with stages of adoption for FOBT and colonoscopy.
Conclusion
This study outlines the distributions of stages of adoption for CRC screening by screening modality. Interventions to improve screening rates should be tailored to individuals in particular stages of adoption for CRC screening by modality. -
Citations
Citations to this article as recorded by- Predictors of stages of adoption of colorectal cancer screening among adults attending primary healthcare centers in Turkey
Elif Dönmez, Nadire Ercan Toptaner, Elvan E. Ata, Zeynep Dülger, Onur Acar
Journal of the Egyptian Public Health Association.2025;[Epub] CrossRef - Factors Affecting Adherence to National Colorectal Cancer Screening: A 12-Year Longitudinal Study Using Multi-Institutional Pooled Data in Korea
Dae Sung Kim, Jeeyoung Hong, Kihyun Ryu, Sang Hyuk Lee, Hwanhyi Cho, Jehyeong Yu, Jieun Lee, Jong-Yeup Kim
Journal of Korean Medical Science.2024;[Epub] CrossRef - A new TGF‐β risk score predicts clinical and immune landscape in colorectal cancer patients
Bing Tang, Binggang Liu, Zhiyao Zeng
Annals of Gastroenterological Surgery.2024; 8(5): 927. CrossRef - Utilization of colorectal cancer screening tests: a systematic review and time trend analysis of nationally representative data
Idris Ola, Rafael Cardoso, Michael Hoffmeister, Hermann Brenner
eClinicalMedicine.2024; 75: 102783. CrossRef - Role of breast cancer screening in the overdiagnosis of thyroid cancer: results from a cross-sectional nationwide survey
Eunhye Lee, Sung Hoon Jeong, Chung Mo Nam, Jae Kwan Jun, Eun-Cheol Park
BMC Women's Health.2023;[Epub] CrossRef - Socioeconomic inequality in organized and opportunistic screening for colorectal cancer: results from the Korean National Cancer Screening Survey, 2009-2021
Xuan Quy Luu, Kyeongmin Lee, Jae Kwan Jun, Mina Suh, Kui Son Choi
Epidemiology and Health.2023; 45: e2023086. CrossRef - The risk of developing colorectal cancer in individuals aged 50-70 years and behavioral changes in high-risk individuals regarding a fecal occult blood test
Renginar ÖZTÜRK DÖNMEZ, Süheyla ÖZSOY, Melek ARDAHAN
Journal of Surgery and Medicine.2022; 6(1): 14. CrossRef - Using Decision Tree Aggregation with Random Forest Model to Identify Gut Microbes Associated with Colorectal Cancer
Dongmei Ai, Hongfei Pan, Rongbao Han, Xiaoxin Li, Gang Liu, Li C. Xia
Genes.2019; 10(2): 112. CrossRef - Colonoscopy and Sigmoidoscopy Use among the Average-Risk Population for Colorectal Cancer: A Systematic Review and Trend Analysis
Rafael Cardoso, Tobias Niedermaier, Chen Chen, Michael Hoffmeister, Hermann Brenner
Cancer Prevention Research.2019; 12(9): 617. CrossRef - Perceptions of colorectal cancer screening and recommendation behaviors among physicians in Korea
Hye Young Shin, Mina Suh, Boyoung Park, Jae Kwan Jun, Kui Son Choi
BMC Cancer.2017;[Epub] CrossRef
- Predictors of stages of adoption of colorectal cancer screening among adults attending primary healthcare centers in Turkey
- 8,760 View
- 180 Download
- 7 Web of Science
- 10 Crossref
- Risk of Second Primary Cancer in People with Non-melanoma Skin Cancer: A Nationwide Cohort Study
- Shu-Hui Wang, Ching-Chi Chi, Zi-Hao Zhao, Tao-Hsin Tung
- Cancer Res Treat. 2018;50(2):428-435. Published online May 10, 2017
- DOI: https://doi.org/10.4143/crt.2017.110
-
Abstract
PDFPubReaderePub
- Purpose
Previous western studies have found Caucasians with skin cancer, either melanoma or nonmelanoma skin cancer (NMSC), have an elevated risk of second primary cancer. Our objective was to assess the risk of second primary cancer in Taiwanese with NMSC.
Materials and Methods
By using data from Taiwan’s National Health Insurance Research Database, we conducted a population-based cohort study to assess the risk of incident second primary cancer in Taiwanese affected by NMSC.
Results
We identified 505 subjects with NMSC and 2,020 matched controls. After adjustment for potential confounders including age, sex, urbanization, and Charlson Comorbidity Index, people who had NMSC had a 1.43-fold (95% confidence interval [CI], 1.05 to 1.96) risk for the development of second primary cancer as comparedwith control group. Menwith NMSC had a 2.99-fold (95% CI, 1.00 to 9.10) risk for second primary cancer involving the lip, oral cavity, and pharynx and a 3.51-fold (95% CI, 1.21 to 10.17) risk for second primary cancer involving the genitourinary organs when compared to the control group. By contrast, women with NMSC did not have an increased risk of second primary cancer.
Conclusion
This study revealed Asians with NMSC have an increased risk of second primary cancer. Our findings can be a useful reference for health care for people diagnosed with NMSC. -
Citations
Citations to this article as recorded by- Epidemiological and genetic insights into the co-occurrence of cutaneous melanoma and hematologic malignancies: A meta-analytic review
Ashmitha Kumar, Arunan Jeyakumar, Alfred K. Lam, Vinod Gopalan
Leukemia Research.2024; 147: 107610. CrossRef - Non‐melanoma skin cancer as a clinical marker for internal malignancies: a nationwide population‐based cohort study
S.J. Yun, J.M. Bae, H. Kim, B.C. Park, J.S. Kim, S.H. Seo, H.H. Ahn, D.Y. Lee, Y.C. Kim, H.J. Park, K.Y. Chung
Journal of the European Academy of Dermatology and Venereology.2020; 34(4): 746. CrossRef
- Epidemiological and genetic insights into the co-occurrence of cutaneous melanoma and hematologic malignancies: A meta-analytic review
- 10,876 View
- 170 Download
- 2 Web of Science
- 2 Crossref
- Awareness of and Attitudes toward Human Papillomavirus Vaccination among Adults in Korea: 9-Year Changes in Nationwide Surveys
- Jin-Kyoung Oh, Bo Yoon Jeong, E Hwa Yun, Min Kyung Lim
- Cancer Res Treat. 2018;50(2):436-444. Published online May 10, 2017
- DOI: https://doi.org/10.4143/crt.2017.174
-
Abstract
PDFPubReaderePub
- Purpose
Human papillomavirus (HPV) vaccination has been included in the National Immunization Program in Korea since 2016. We aimed to evaluate changes in the awareness of and attitudes toward HPV vaccination, among adults in Korea since the first introduction of the vaccines in 2007.
Materials and Methods
A nationwide population-based survey was conducted in 2016 for 1,200 nationally representative Korean men and women; the data obtained were compared with the data from the nationwide survey conducted in 2007.
Results
A significant increase in the awareness of HPV infection (35.8%) and vaccination (36.9%) was observed in 2016 from 13.3% and 8.6% in 2007, respectively. Willingness to be vaccinated against HPV decreased from 55.0% in 2007 to 25.8% in 2016, and the proportion of respondents expressing uncertainty increased from 28.3% in 2007 to 43.3% in 2016. Only 12.1% of men and 22.0% of women knew about the free national HPV vaccination program for girls, launched in June 2016. Younger women, with higher income level, awareness of the HPV vaccine, and perception of the seriousness of infections had a higher willingness to be vaccinated. A high education level, awareness of HPV infection and vaccination, and perception of the seriousness of infection were positively associated with the willingness of respondents to vaccinate their daughters.
Conclusion
Raising the awareness of HPV infection and vaccination with appropriate knowledge is necessary for the successful implementation of the national HPV vaccination program. -
Citations
Citations to this article as recorded by- An investigation into the human papilloma virus (HPV) vaccination among undergraduate medical students (A prospective cross-sectional KAP survey)
Remah M Kamel, Aseel Alomari, Abeer Ismail, Rogayah Alballa, A’laa Almowallad, Laila Alsankari, Mona Sabsabi
Obstetrics & Gynecology International Journal.2024; 15(5): 194. CrossRef - Parental Factors Affecting Decision to Vaccinate Their Daughters against Human Papillomavirus
Yoon Park, Moran Ki, Hyunju Lee, Jae-Kwan Lee, Jin-Kyoung Oh
Cancer Prevention Research.2023; 16(3): 133. CrossRef - Parental intention to vaccinate daughters with the human papillomavirus vaccine in Korea: a nationwide cross-sectional survey
Yejin Ha, Kyeongmin Lee, Bomi Park, Mina Suh, Jae Kwan Jun, Kui Son Choi
Epidemiology and Health.2023; 45: e2023076. CrossRef - ARE WOMEN AWARE OF THE VACCINE AGAINST HUMAN PAPILLOMAVIRUS? A HOSPITAL-FOCUSED CROSS-SECTIONAL STUDY
Ülkü Ayşe TÜRKER, Binali ÇATAK
SDÜ Tıp Fakültesi Dergisi.2022; 29(2): 249. CrossRef - Trends in cervical cancer screening rates among Korean women: results of the Korean National Cancer Screening Survey, 2005–2020
Hye Young Shin, Yun Yeong Lee, Soo Yeon Song, Bomi Park, Mina Suh, Kui Son Choi, Jae Kwan Jun
Journal of Gynecologic Oncology.2022;[Epub] CrossRef - Perception of human papilloma virus (HPV) vaccination during the COVID-19 pandemic
Ye Won Jung, Soo Youn Song, Won Kyo Shin, Su Min Chung, Ji Won Park, Heon Jong Yoo
Medicine.2022; 101(43): e31389. CrossRef - Awareness of and practice toward cancer prevention recommendations: results of the Korean National Cancer Prevention Awareness and Practice Survey in 2021
Jin-Kyoung Oh, Eunjung Park, Byungmi Kim, Yoon-Jung Choi, E Hwa Yun, Min Kyung Lim, Jeong-Soo Im, Eun Young Park
Epidemiology and Health.2022; 44: e2022068. CrossRef - The emergence of oral cavity cancer and the stabilization of oropharyngeal cancer: Recent contrasting epidemics in the South Korean population
Yuh‐Seog Jung, Jungirl Seok, Seri Hong, Chang Hwan Ryu, Junsun Ryu, Kyu‐Won Jung
Cancer.2021; 127(10): 1638. CrossRef - Enhanced disease progression due to persistent HPV-16/58 infections in Korean women: a systematic review and the Korea HPV cohort study
Jaehyun Seong, Sangmi Ryou, JeongGyu Lee, Myeongsu Yoo, Sooyoung Hur, Byeong-Sun Choi
Virology Journal.2021;[Epub] CrossRef - Factors Associated with the HPV Vaccination among Korean Americans and Koreans: A Systematic Review
Soojung Jo, Soo-Yeon Han, Connor A. Walters
International Journal of Environmental Research and Public Health.2021; 19(1): 51. CrossRef - Inequalities in Awareness and Attitude towards HPV and Its Vaccine between Local and Migrant Residents Who Participated in Cervical Cancer Screening in Shenzhen, China
Wei Lin, Yueyun Wang, Zhihua Liu, Bin Chen, Shixin Yuan, Bo Wu, Lin Gong
Cancer Research and Treatment.2020; 52(1): 207. CrossRef - Multidimensional social and cultural norms influencing HPV vaccine hesitancy in Asia
Li Ping Wong, Pooi-Fong Wong, Megat Mohamad Amirul Amzar Megat Hashim, Liyuan Han, Yulan Lin, Zhijian Hu, Qinjian Zhao, Gregory D. Zimet
Human Vaccines & Immunotherapeutics.2020; 16(7): 1611. CrossRef - Chinese Residents’ Perceptions of COVID-19 During the Pandemic: Online Cross-sectional Survey Study
Tingting Cui, Guoping Yang, Lili Ji, Lin Zhu, Shiqi Zhen, Naiyang Shi, Yan Xu, Hui Jin
Journal of Medical Internet Research.2020; 22(11): e21672. CrossRef - Perceptions of nurses on human papillomavirus vaccinations in the Republic of Korea
Hae Won Kim, Hyang Yuol Lee, Seong Eun Kim, Hye Young Ahn, Yeon Hee Kim, Young Jin Lee, Italo Francesco Angelillo
PLOS ONE.2019; 14(2): e0211475. CrossRef - Current knowledge of and attitudes toward human papillomavirus‐related disease prevention among Japanese: A large‐scale questionnaire study
Yukio Suzuki, Akiko Sukegawa, Aya Nishikawa, Kazumi Kubota, Yoko Motoki, Mikiko Asai‐Sato, Yutaka Ueda, Masayuki Sekine, Takayuki Enomoto, Fumiki Hirahara, Takeharu Yamanaka, Etsuko Miyagi
Journal of Obstetrics and Gynaecology Research.2019; 45(5): 994. CrossRef - High-Risk Human Papillomavirus Infection and the Risk of Cardiovascular Disease in Korean Women
Eun-Jeong Joo, Yoosoo Chang, Min-Jung Kwon, Ara Cho, Hae Suk Cheong, Seungho Ryu
Circulation Research.2019; 124(5): 747. CrossRef - Awareness and attitude towards human papillomavirus and its vaccine among females with and without daughter(s) who participated in cervical cancer screening in Shenzhen, China
Wei Lin, Yueyun Wang, Zhihua Liu, Bin Chen, Shixin Yuan, Bo Wu, Lin Gong
Tropical Medicine & International Health.2019; 24(9): 1054. CrossRef
- An investigation into the human papilloma virus (HPV) vaccination among undergraduate medical students (A prospective cross-sectional KAP survey)
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- Ferroptosis: A Novel Anti-tumor Action for Cisplatin
- Jipeng Guo, Bingfei Xu, Qi Han, Hongxia Zhou, Yun Xia, Chongwen Gong, Xiaofang Dai, Zhenyu Li, Gang Wu
- Cancer Res Treat. 2018;50(2):445-460. Published online May 10, 2017
- DOI: https://doi.org/10.4143/crt.2016.572
-
Abstract
PDFPubReaderePub
- Purpose
Ferroptosis is a new mode of regulated cell death, which is completely distinct from other cell death modes based on morphological, biochemical, and genetic criteria. This study evaluated the therapeutic role of ferroptosis in classic chemotherapy drugs, including the underlying mechanism.
Materials and Methods
Cell viabilitywas detected by using the methylthiazoltetrazlium dye uptake method. RNAiwas used to knockout iron-responsive element binding protein 2, and polymerase chain reaction, western blot was used to evaluate the efficiency. Intracellular reduced glutathione level and glutathione peroxidases activitywere determined by related assay kit. Intracellularreactive oxygen species levelswere determined by flowcytometry. Electron microscopywas used to observe ultrastructure changes in cell.
Results
Among five chemotherapeutic drugs screened in this study, cisplatin was found to be an inducer for both ferroptosis and apoptosis in A549 and HCT116 cells. The depletion of reduced glutathione caused by cisplatin and the inactivation of glutathione peroxidase played the vital role in the underlying mechanism. Besides, combination therapy of cisplatin and erastin showed significant synergistic effect on their anti-tumor activity.
Conclusion
Ferroptosis had great potential to become a new approach in anti-tumor therapies and make up for some classic drugs, which open up a new way for their utility in clinic. -
Citations
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Megha Mete, Amiya Ojha, Priyanka Dhar, Deeplina Das
Molecular Biotechnology.2025; 67(4): 1290. CrossRef - Cell Death and Survival Mechanisms in Cholangiocarcinogenesis
Luana D'Artista, Marco Seehawer
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Ademola C Famurewa, Nupura Manish Prabhune, Sudharshan Prabhu
Journal of Pharmacy and Pharmacology.2025; 77(1): 1. CrossRef - Illuminating cisplatin-induced ferroptosis in non-small-cell lung cancer with biothiol-activatable fluorescent/photoacoustic bimodal probes
Li Xu, Hongwen Liu, Yi Kong, Lingyun Li, Jia Li, Kang Li, Shuzhi Liang, Bolin Chen
Journal of Materials Chemistry B.2025; 13(1): 239. CrossRef - EMC2 suppresses ferroptosis via regulating TFRC in nasopharyngeal carcinoma
Xianghui Chen, Xiaoyan Wang, Yuxia Zou, Yan Wang, Tingting Duan, Zijie Zhou, Yi Huang, Qing Ye
Translational Oncology.2025; 52: 102251. CrossRef - Synergistic effects of dihydroartemisinin and cisplatin on inducing ferroptosis in gastric cancer through GPX4 inhibition
Huina Wang, Chanchan Lu, Haihua Zhou, Xiaojun Zhao, Chuanjiang Huang, Zhiyi Cheng, Guiyuan Liu, Xiaolan You
Gastric Cancer.2025; 28(2): 187. CrossRef - Research progress on gene mutations and drug resistance in leukemia
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Manikandan Vani Raju, Meenakshi Kaniyur Chandrasekaran, Rathi Muthaiyan Ahalliya, Gopalakrishnan Velliyur Kanniappan
Advances in Redox Research.2025; 14: 100117. CrossRef - DLBCL cells with ferroptosis morphology can be detected with a deep convolutional neural network
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Hereditas.2025;[Epub] CrossRef - Targeting ferroptosis in gastrointestinal tumors: Interplay of iron-dependent cell death and autophagy
Mohamad Hosein Safari, Payman Rahimzadeh, Elmira Alaei, Mina Alimohammadi, Negin Esfandiari, Salman Daneshi, Neda Malgard, Najma Farahani, Afshin Taheriazam, Mehrdad Hashemi
Molecular and Cellular Probes.2025; 79: 102013. CrossRef - Investigating the interaction between calcium signaling and ferroptosis for novel cancer treatment
Hao-xin Yan, Yi-zhong Zhang, Yu-qing Niu, Yu-wei Wang, Li-hua Liu, Yu-ping Tang, Ju-min Huang, Elaine Lai-Han Leung
Phytomedicine.2025; 137: 156377. CrossRef - A systematical review on traditional Chinese medicine treating chronic diseases via regulating ferroptosis from the perspective of experimental evidence and clinical application
Yuanyuan Zhang, Fazhi Su, Enlin Zhu, Yanping Sun, Haixue Kuang, Qiuhong Wang
Chinese Herbal Medicines.2025; 17(2): 246. CrossRef - RSL3 induces ferroptosis by activating the NF-κB signalling pathway to enhance the chemosensitivity of triple-negative breast cancer cells to paclitaxel
Jialin Yuan, Cong Liu, Chengwei Jiang, Ning Liu, Zhaoying Yang, Hua Xing
Scientific Reports.2025;[Epub] CrossRef - Design, synthesis, and biological evaluation of quinolinyl-ureido-phenyl-hydrazide derivatives and quinolinyl-hydrazide derivatives as anticancer agents targeting Nur77-mediated ferroptosis
Yan-fang Gao, Yi-jing Yang, Jing-bo Qin, Ming-yue Yu, Sheng-wei Hu, Hao-fan Zhang, Fan-hong Lin, Hong-yu Hu, Mei-juan Fang, Jin-Zhang Zeng
European Journal of Medicinal Chemistry.2025; 291: 117559. CrossRef - Ferroptosis: a novel perspective on tumor immunotherapy
Yuan Xu, Mingpai Ge, Yuqing Xu, Kai Yin
Frontiers in Immunology.2025;[Epub] CrossRef - HPV E6/E7‐Induced Acetylation of a Peptide Encoded by a Long Non‐Coding RNA Inhibits Ferroptosis to Promote the Malignancy of Cervical Cancer
Xiaoyu Qi, Jing Zhou, Xinyue Wang, Yan Shen, Yuxun Cao, Liangzi Jiang, Miaomiao Shen, Haoran Zhang, Tianjiao Wang, Pengjun Wei, Ruoqi Xu, Yue Yang, Xiangya Ding, Cong Wang, Xuemei Jia, Qin Yan, Wan Li, Chun Lu
Advanced Science.2025;[Epub] CrossRef - The role of ferroptosis in colorectal cancer and its potential synergy with immunotherapy
Wenhua Xia, Yuanhao Lv, Yan Zou, Zhanting Kang, Zhaoyi Li, Jiaqi Tian, Hongyan Zhou, Wei Su, Jiateng Zhong
Frontiers in Immunology.2025;[Epub] CrossRef - Harnessing ferroptosis for precision oncology: challenges and prospects
Roberto Fernández-Acosta, Iuliana Vintea, Ine Koeken, Behrouz Hassannia, Tom Vanden Berghe
BMC Biology.2025;[Epub] CrossRef - Research Progress on Iron Overload and Lung Diseases
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Advances in Clinical Medicine.2025; 15(01): 1331. CrossRef - STX1A regulates ferroptosis and chemoresistance in gastric cancer through mitochondrial function modulation
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Human Cell.2025;[Epub] CrossRef - Bibliometric analysis of ferroptosis: a comprehensive evaluation of its contribution to lung cancer
Feifei Yao, Feng Guo, Chuanzhong Sun, Erdong Wang, Hang Wang, Na Li
Frontiers in Genetics.2025;[Epub] CrossRef - Half‐Sandwich Organometallic Ir(III) and Ru(II) Compounds and their Interactions with Biomolecules
Sandra Kozieł, Daria Wojtala, Magdalena Szmitka, Monika Lesiów, Aleksandra Ziółkowska, Jacek Sawka, Edgar Del Carpio, Debbie C. Crans, Urszula K. Komarnicka
ChemPlusChem.2025;[Epub] CrossRef - Regulation and therapy: the role of ferroptosis in DLBCL
Yifan Wang, Zhengmei He, Xinyu Dong, Yiming Yao, Qiuni Chen, Yuye Shi, Yuan Deng, Quane Zhang, Liang Yu, Chunling Wang
Frontiers in Pharmacology.2025;[Epub] CrossRef - Epithelial-mesenchymal transition promotes metabolic reprogramming to suppress ferroptosis
Wenzheng Guo, Zhibing Duan, Jingjing Wu, Binhua P. Zhou
Seminars in Cancer Biology.2025; 112: 20. CrossRef - Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin
Xiang Huang, Jie Zhang, Yixian Cun, Meijun Ye, Zhijun Ren, Wenbing Guo, Xiaojun Ma, Jiayin Liu, Weiwei Luo, Xiang Sun, Jingwen Shao, Zehong Wu, Xiaofeng Zhu, Jinkai Wang
Molecular Cell.2025; 85(7): 1349. CrossRef - Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells
Zheng Zhang, Huaxiang Xu, Junyi He, Qiangsheng Hu, Yuxin Liu, Zijin Xu, Wenhui Lou, Wenchuan Wu, Lei Zhang, Ning Pu, Chenye Shi, Yaolin Xu, Wenquan Wang, Liang Liu
Cell Death & Disease.2025;[Epub] CrossRef - BMAL1-depletion remodels ceramide metabolism to regulate ferroptosis and sorafenib chemosensitivity in acute myeloid leukemia
Hong Zheng, Zhi Lin, Dan Wang, Jing Zhang, Ting Zeng, Jie Shen, Jia-Da Li, Minghua Yang
iScience.2025; 28(4): 112054. CrossRef - Ferroptosis meets inflammation: A new frontier in cancer therapy
Hu Liu, Hui Xue, Qian Guo, Xutong Xue, Lixue Yang, Kaijun Zhao, Yu'e Liu
Cancer Letters.2025; 620: 217696. CrossRef - Ferroptosis in cancer: Mechanisms, therapeutic strategies, and clinical implications
Mina Pourhabib Mamaghani, Seyedeh Nasibeh Mousavikia, Hosein Azimian
Pathology - Research and Practice.2025; 269: 155907. CrossRef - SCARB1 links cholesterol metabolism-mediated ferroptosis inhibition to radioresistance in tumor cells
Xiaojuan Mao, Jingwen Xiong, Mengjiao Cai, Chao Wang, Qian He, Binxian Wang, Jing Chen, Zhengtao Xiao, Baofeng Wang, Suxia Han, Yilei Zhang
Journal of Advanced Research.2025;[Epub] CrossRef - Ferroptosis: a potential target for non-surgical treatment of laryngeal cancer
Yang Luo, Yuzhu He, Shuang Xu, Yuxiang Chen, Fengfeng Qin, Wenjian Hu
European Archives of Oto-Rhino-Laryngology.2025;[Epub] CrossRef - Mitochondrial chaperonin DNAJC15 promotes vulnerability to ferroptosis of chemoresistant ovarian cancer cells
Stefano Miglietta, Manuela Sollazzo, Iacopo Gherardi, Sara Milioni, Beatrice Cavina, Lorena Marchio, Monica De Luise, Camelia Alexandra Coada, Marco Fiorillo, Anna Myriam Perrone, Ivana Kurelac, Giuseppe Gasparre, Luisa Iommarini, Anna Maria Ghelli, Anna
Open Biology.2025;[Epub] CrossRef - Targeting ferroptosis: the role of non-coding RNAs in hepatocellular carcinoma progression and therapy
Weijia Wang, Behishta Hashimi, Ping Wang
Naunyn-Schmiedeberg's Archives of Pharmacology.2025;[Epub] CrossRef - CD44 variant exons induce chemoresistance by modulating cell death pathways
Maria Yanova, Evgeniya Stepanova, Diana Maltseva, Alexander Tonevitsky
Frontiers in Cell and Developmental Biology.2025;[Epub] CrossRef - Cepharanthine hydrochloride: a novel ferroptosis-inducing agent for prostate cancer treatment
Jing-Song Guan, Jing Jia, Ze-Xiu Huang, Yu-Qing Zhou, Jing-Jie Zheng, Qi-Man Lin, Yi-Fei Wang, Jiang-Lin Fan, Yao Wang
Frontiers in Pharmacology.2025;[Epub] CrossRef - Synergistic antitumor efficacy of gemcitabine and cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via Sp1-SAT1-polyamine metabolism pathway
Wanhui Wei, Yuanyuan Lu, Qian Hu, Jinwen Yin, Youwei Wang, Heng Zhang, Qiu Zhao, Lan Liu
Cellular Oncology.2024; 47(1): 321. CrossRef - Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy
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Immunological Reviews.2024; 321(1): 300. CrossRef - Impact of TP53‐induced glycolysis and apoptosis regulator on malignant activity and resistance to ferroptosis in intrahepatic cholangiocarcinoma
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Cancer Science.2024; 115(1): 170. CrossRef - Verteporfin Exerts Anticancer Effects and Reverses Resistance to Paclitaxel via Inducing Ferroptosis in Esophageal Squamous Cell Cancer Cells
Xue-Wei Wang, Zi-Yi Yang, Ting Li, Xin-Ran Zhao, Xiao-Zhong Li, Xiao-Xia Wang
Molecular Biotechnology.2024; 66(9): 2558. CrossRef - Heteronemin promotes iron-dependent cell death in pancreatic cancer
Gizem Kaftan, Mümin Alper Erdoğan, Mohamed El-Shazly, Mei-Chin Lu, Shou-Ping Shih, Hung-Yu Lin, Luciano Saso, Güliz Armagan
Naunyn-Schmiedeberg's Archives of Pharmacology.2024; 397(3): 1865. CrossRef - Prognostic significance of a 3-gene ferroptosis-related signature in lung cancer via LASSO analysis and cellular functions of UBE2Z
Bin Xie, Qiong Chen, Ziyu Dai, Chen Jiang, Jingyi Sun, Anqi Guan, Xi Chen
Computational Biology and Chemistry.2024; 113: 108192. CrossRef - Yi-qi-hua-yu-jie-du decoction induces ferroptosis in cisplatin-resistant gastric cancer via the AKT/GSK3β/NRF2/GPX4 axis
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Phytomedicine.2024; 123: 155220. CrossRef - Mitochondrial dysfunction decreases cisplatin sensitivity in gastric cancer cells through upregulation of integrated stress response and mitokine GDF15
Sheng‐Fan Wang, Yuh‐Lih Chang, Ting‐Yu Liu, Kuo‐Hung Huang, Wen‐Liang Fang, Anna Fen‐Yau Li, Tien‐Shun Yeh, Giun‐Yi Hung, Hsin‐Chen Lee
The FEBS Journal.2024; 291(6): 1131. CrossRef - Current and Potential Roles of Ferroptosis in Bladder Cancer
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Current Medical Science.2024; 44(1): 51. CrossRef - BHLHE40 Inhibits Ferroptosis in Pancreatic Cancer Cells via Upregulating SREBF1
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Gourav Singh, Prashant Kesharwani, Gireesh Kumar Singh, Saroj Kumar, Anjaneyulu Putta, Gyan Modi
Bioorganic & Medicinal Chemistry.2024; 98: 117564. CrossRef - The application of nanoparticles based on ferroptosis in cancer therapy
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Journal of Materials Chemistry B.2024; 12(2): 413. CrossRef - Stability-Enhanced Cisplatin Gold Nanoparticles as Therapeutic Anticancer Agents
Tae Joon Cho, Vytas Reipa, Justin M. Gorham, John M. Pettibone, Alessandro Tona, Aaron Johnston-Peck, Jingyu Liu, Bryant C. Nelson, Vincent A. Hackley
ACS Applied Nano Materials.2024; 7(1): 836. CrossRef - Mechanism of ferroptosis in breast cancer and research progress of natural compounds regulating ferroptosis
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Journal of Cellular and Molecular Medicine.2024;[Epub] CrossRef - Iron accumulation and lipid peroxidation: implication of ferroptosis in hepatocellular carcinoma
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Frontiers in Endocrinology.2024;[Epub] CrossRef - Crosstalk between ferroptosis and cuproptosis: From mechanism to potential clinical application
Na Liu, Minbin Chen
Biomedicine & Pharmacotherapy.2024; 171: 116115. CrossRef - A risk model based on 10 ferroptosis regulators and markers established by LASSO-regularized linear Cox regression has a good prognostic value for ovarian cancer patients
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Diagnostic Pathology.2024;[Epub] CrossRef - The role of ferroptosis in cardio-oncology
Kai Hou, Lin Liu, Zhi-Hui Fang, Wei-Xing Zong, Daqiang Sun, Zhigang Guo, Lu Cao
Archives of Toxicology.2024; 98(3): 709. CrossRef - Exploring the Use of Intracellular Chelation and Non-Iron Metals to Program Ferroptosis for Anticancer Application
Oscar Claudio-Ares, Jeileen Luciano-Rodríguez, Yolmarie L. Del Valle-González, Selene L. Schiavone-Chamorro, Alex J. Pastor, Javier O. Rivera-Reyes, Carmen L. Metzler, Lizandra M. Domínguez-Orona, Brenda Lee Vargas-Pérez, Rachid Skouta, Arthur D. Tinoco
Inorganics.2024; 12(1): 26. CrossRef - Ferroptosis: a dual-edged sword in tumour growth
Xiangye Zhao, Xiaoning Li, Yinghui Xu
Frontiers in Pharmacology.2024;[Epub] CrossRef - Propionate promotes ferroptosis and apoptosis through mitophagy and ACSL4-mediated ferroptosis elicits anti-leukemia immunity
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Free Radical Biology and Medicine.2024; 213: 36. CrossRef - Programmed cell death in tumor immunity: mechanistic insights and clinical implications
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Frontiers in Immunology.2024;[Epub] CrossRef - Extracellular vesicle-mediated ferroptosis, pyroptosis, and necroptosis: potential clinical applications in cancer therapy
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Cell Death Discovery.2024;[Epub] CrossRef - Modulating ferroptosis sensitivity: environmental and cellular targets within the tumor microenvironment
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Journal of Experimental & Clinical Cancer Research.2024;[Epub] CrossRef - Chemo-photothermal nanoplatform with diselenide as the key for ferroptosis in colorectal cancer
Kaili Deng, Hailong Tian, Tingting Zhang, Yajie Gao, Edouard C. Nice, Canhua Huang, Na Xie, Guoliang Ye, Yuping Zhou
Journal of Controlled Release.2024; 366: 684. CrossRef - Ferroptosis in head and neck squamous cell carcinoma: from pathogenesis to treatment
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Frontiers in Pharmacology.2024;[Epub] CrossRef - Lysine acetyltransferase KAT2A modulates ferroptosis during colorectal cancer development
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Scandinavian Journal of Gastroenterology.2024; 59(4): 437. CrossRef - Recent Progress in Ferroptosis Induced Tumor Cell Death by Anti‐tumor Metallic complexes
Yong‐Chang Zhou, Tian‐Kun Zhao, Si‐Man Tao, Peng Wang, Yi‐Chen Guan, Ke‐Pei Yang, Sheng‐Qiang Chen, Xiu‐Ying Pu
Chemistry – An Asian Journal.2024;[Epub] CrossRef - Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer
Tong-Mei Shi, Xiao-Fei Chen, Huihui Ti
Journal of Medicinal Chemistry.2024; 67(4): 2238. CrossRef - Novel application of the ferroptosis-related genes risk model associated with disulfidptosis in hepatocellular carcinoma prognosis and immune infiltration
Jiayan Wei, Jinsong Wang, Xinyi Chen, Li Zhang, Min Peng
PeerJ.2024; 12: e16819. CrossRef - Edaravone-loaded poly(amino acid) nanogel inhibits ferroptosis for neuroprotection in cerebral ischemia injury
Yunhan Zhang, Zhulin Zou, Shuang Liu, Fangfang Chen, Minglu Li, Haoyang Zou, Haiyan Liu, Jianxun Ding
Asian Journal of Pharmaceutical Sciences.2024; 19(2): 100886. CrossRef - A Pt(II) complex bearing N-heterocycle ring induced ferroptotic cell death in ovarian cancer
Xiaomin Shen, Yue Peng, Haixia Zhou, Xiaoxia Ye, Zhong Han, Xiangchao Shi
Journal of Inorganic Biochemistry.2024; 253: 112502. CrossRef - A Smooth Muscle Cell-Based Ferroptosis Model to Evaluate Iron-Chelating Molecules for Cardiovascular Disease Treatment
Sarah El Hajj, Laetitia Canabady-Rochelle, Isabelle Fries-Raeth, Caroline Gaucher
Current Issues in Molecular Biology.2024; 46(2): 1348. CrossRef - DTTZ suppresses ferroptosis and reverses mitochondrial dysfunction in normal tissues affected by chemotherapy
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Biomedicine & Pharmacotherapy.2024; 172: 116227. CrossRef - Cancer associated fibroblast secreted miR-432-5p targets CHAC1 to inhibit ferroptosis and promote acquired chemoresistance in prostate cancer
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Oncogene.2024; 43(27): 2104. CrossRef - Iron Oxide Nanoparticles Carrying microRNA-124 Promote Ferroptosis in Treatment of Prostate Cancer
Min Liu, Chuanbing Xu, Huichao Dong, Dongshen Jia, Dongfang Hao, Ruozen Rong, Yao Peng
Journal of Biomedical Nanotechnology.2024; 20(2): 224. CrossRef - Targeting LGR4–Wnt activates ferroptosis and reverses drug resistance in colorectal cancer
Nature Cancer.2024; 5(4): 542. CrossRef - Recent research progress based on ferroptosis-related signaling pathways and the tumor microenvironment on it effects
Shijing Yu, Lingwu Tong, Jiangwen Shen, Chenglei Li, Yongshan Hu, Keke Feng, Jingwei Shao
European Journal of Medicinal Chemistry.2024; 269: 116290. CrossRef - TRAIL predisposes non-small cell lung cancer to ferroptosis by regulating ASK-1/JNK1 pathway
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Discover Oncology.2024;[Epub] CrossRef - G protein-coupled estrogen receptor activates PI3K/AKT/mTOR signaling to suppress ferroptosis via SREBP1/SCD1-mediated lipogenesis
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Molecular Medicine.2024;[Epub] CrossRef - Cisplatin Nephrotoxicity Is Critically Mediated by the Availability of BECLIN1
Tillmann Bork, Camila Hernando-Erhard, Wei Liang, Zhejia Tian, Kosuke Yamahara, Tobias B. Huber
International Journal of Molecular Sciences.2024; 25(5): 2560. CrossRef - Ailanthone induces autophagy and ferroptosis in non‑small cell lung cancer Lewis cells
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Molecular and Clinical Oncology.2024;[Epub] CrossRef - Ferroptosis in lung cancer: dual role, multi-level regulation, and new therapeutic strategies
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Frontiers in Oncology.2024;[Epub] CrossRef - Curcumin activates the JNK signaling pathway to promote ferroptosis in colon cancer cells
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Chemical Biology & Drug Design.2024;[Epub] CrossRef - Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies
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Signal Transduction and Targeted Therapy.2024;[Epub] CrossRef - AURKA knockdown inhibits esophageal squamous cell carcinoma progression through ferroptosis
Yuan Mi, Liying Chen, Cong Wang, Yuxin Miao, Chuntao Song, Jie Su, Lei Wang
Heliyon.2024; 10(7): e28365. CrossRef - Harnessing ferroptosis for enhanced sarcoma treatment: mechanisms, progress and prospects
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Qian Li, Qibin Song, Huadong Pei, Yali Chen
Chinese Medical Journal.2024; 137(7): 818. CrossRef - Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer
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Cellular & Molecular Biology Letters.2024;[Epub] CrossRef - Meningioma achieves malignancy and erastin-induced ferroptosis resistance through FOXM1-AURKA-NRF2 axis
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Redox Biology.2024; 72: 103137. CrossRef - Esculin induces endoplasmic reticulum stress and drives apoptosis and ferroptosis in colorectal cancer via PERK regulating eIF2α/CHOP and Nrf2/HO-1 cascades
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Journal of Ethnopharmacology.2024; 328: 118139. CrossRef - A multi-mode Rhein-based nano-platform synergizing ferrotherapy/chemotherapy-induced immunotherapy for enhanced tumor therapy
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Acta Biomaterialia.2024; 180: 383. CrossRef - Synergistic eradicating impact of 5-fluouracil with FeO nanoparticles-diethyldithiocarbamate in colon cancer spheroids
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Nanomedicine.2024; 19(11): 979. CrossRef - Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting
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Muhammad Hossein Ashoub, Razieh Razavi, Kamran Heydaryan, Masoud Salavati-Niasari, Mahnaz Amiri
European Journal of Medical Research.2024;[Epub] CrossRef - LPCAT2 inhibits colorectal cancer progression via the PRMT1/SLC7A11 axis
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Oncogene.2024; 43(22): 1714. CrossRef - Endometrial stem cells alleviate cisplatin-induced ferroptosis of granulosa cells by regulating Nrf2 expression
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Reproductive Biology and Endocrinology.2024;[Epub] CrossRef - FSP1-mediated ferroptosis in cancer: from mechanisms to therapeutic applications
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Apoptosis.2024; 29(7-8): 1019. CrossRef - Recent advancements in nanomaterial-mediated ferroptosis-induced cancer therapy: Importance of molecular dynamics and novel strategies
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Life Sciences.2024; 346: 122629. CrossRef - Unlocking ferroptosis in prostate cancer — the road to novel therapies and imaging markers
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Inorganic Chemistry Frontiers.2024; 11(10): 2914. CrossRef - Cancer-associated fibroblasts secrete FGF5 to inhibit ferroptosis to decrease cisplatin sensitivity in nasopharyngeal carcinoma through binding to FGFR2
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Cell Death & Disease.2024;[Epub] CrossRef - Ferroptosis-related lncRNA NRAV affects the prognosis of hepatocellular carcinoma via the miR-375-3P/SLC7A11 axis
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BMC Cancer.2024;[Epub] CrossRef - Oleanolic Acid Acetate Alleviates Cisplatin-Induced Nephrotoxicity via Inhibition of Apoptosis and Necroptosis In Vitro and In Vivo
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Acta Pharmaceutica Sinica B.2024; 14(7): 2815. CrossRef - Polyphyllin I induces rapid ferroptosis in acute myeloid leukemia through simultaneous targeting PI3K/SREBP-1/SCD1 axis and triggering of lipid peroxidation
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International Immunopharmacology.2024; 134: 112203. CrossRef - Tumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling
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Frontiers in Cell and Developmental Biology.2024;[Epub] CrossRef - Unveiling ferroptosis as a promising therapeutic avenue for colorectal cancer and colitis treatment
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Acta Pharmaceutica Sinica B.2024; 14(9): 3785. CrossRef - The Role of Nrf2 in the Regulation of Mitochondrial Function and Ferroptosis in Pancreatic Cancer
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Pharmaceuticals.2024; 17(10): 1380. CrossRef - Asiatic acid induces lung cancer toxicity by triggering SRC-mediated ferroptosis
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Biomolecules.2024; 14(11): 1443. CrossRef - LncRNA MALAT1 promotes Erastin-induced ferroptosis in the HBV-infected diffuse large B-cell lymphoma
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Frontiers in Oncology.2024;[Epub] CrossRef - Infection of Helicobacter pylori contributes to the progression of gastric cancer through ferroptosis
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European Journal of Medicinal Chemistry.2023; 247: 115015. CrossRef - Ferroptosis: a potential therapeutic target for Alzheimer’s disease
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World Journal of Gastroenterology.2023; 29(3): 469. CrossRef - Ferroptosis as a therapeutic target for inflammation-related intestinal diseases
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Chemico-Biological Interactions.2023; 371: 110348. CrossRef - RNA methylation and cellular response to oxidative stress-promoting anticancer agents
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International Journal of General Medicine.2023; Volume 16: 481. CrossRef - Overexpression of PRDX2 in Adipose-Derived Mesenchymal Stem Cells Enhances the Therapeutic Effect in a Neurogenic Erectile Dysfunction Rat Model by Inhibiting Ferroptosis
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Phytochemistry.2023; 210: 113674. CrossRef - Ferroptosis landscape in prostate cancer from molecular and metabolic perspective
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Frontiers in Molecular Biosciences.2022;[Epub] CrossRef - Molecular mechanisms of reactive oxygen species in regulated cell deaths: Impact of ferroptosis in cancer therapy
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Molecular and Cellular Probes.2022; 64: 101821. CrossRef - Cullin-9/p53 mediates HNRNPC degradation to inhibit erastin-induced ferroptosis and is blocked by MDM2 inhibition in colorectal cancer
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Frontiers in Oncology.2022;[Epub] CrossRef - Ferroptosis and Tumor Drug Resistance: Current Status and Major Challenges
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Frontiers in Pharmacology.2022;[Epub] CrossRef - Post-Translational Modifications of p53 in Ferroptosis: Novel Pharmacological Targets for Cancer Therapy
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International Journal of Biological Macromolecules.2022; 215: 398. CrossRef - Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy
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Frontiers in Cell and Developmental Biology.2022;[Epub] CrossRef - PARPi treatment enhances radiotherapy-induced ferroptosis and antitumor immune responses via the cGAS signaling pathway in colorectal cancer
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Frontiers in Immunology.2022;[Epub] CrossRef - C-phycocyanin alleviated cisplatin-induced oxidative stress and inflammation via gut microbiota—metabolites axis in mice
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Asian Journal of Pharmaceutical Sciences.2022; 17(5): 613. CrossRef - The Relationship Between Ferroptosis and Diseases
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Journal of Multidisciplinary Healthcare.2022; Volume 15: 2261. CrossRef - Diclofenac Sensitizes Signet Ring Cell Gastric Carcinoma Cells to Cisplatin by Activating Autophagy and Inhibition of Survival Signal Pathways
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European Journal of Medicinal Chemistry.2022; 244: 114861. CrossRef - Integrative analysis of enrichment and prognostic value of ferroptosis-related genes and pathways in multiple myeloma
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Carcinogenesis.2022; 43(11): 1050. CrossRef - Regulation mechanism of ferroptosis and its research progress in tumor immunotherapy
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Frontiers in Medicine.2021;[Epub] CrossRef - Effect of Micelle-Incorporated Cisplatin With Sizes Ranging From 8 to 40 nm for the Therapy of Lewis Lung Carcinoma
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Frontiers in Pharmacology.2021;[Epub] CrossRef - PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer
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- Molecular Signature for Lymphatic Invasion Associated with Survival of Epithelial Ovarian Cancer
- E Sun Paik, Hyun Jin Choi, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Duk-Soo Bae, Chel Hun Choi
- Cancer Res Treat. 2018;50(2):461-473. Published online May 22, 2017
- DOI: https://doi.org/10.4143/crt.2017.104
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
We aimed to develop molecular classifier that can predict lymphatic invasion and their clinical significance in epithelial ovarian cancer (EOC) patients.
Materials and Methods
We analyzed gene expression (mRNA, methylated DNA) in data from The Cancer Genome Atlas. To identify molecular signatures for lymphatic invasion, we found differentially expressed genes. The performance of classifier was validated by receiver operating characteristics analysis, logistic regression, linear discriminant analysis (LDA), and support vector machine (SVM). We assessed prognostic role of classifier using random survival forest (RSF) model and pathway deregulation score (PDS). For external validation,we analyzed microarray data from 26 EOC samples of Samsung Medical Center and curatedOvarianData database.
Results
We identified 21 mRNAs, and seven methylated DNAs from primary EOC tissues that predicted lymphatic invasion and created prognostic models. The classifier predicted lymphatic invasion well, which was validated by logistic regression, LDA, and SVM algorithm (C-index of 0.90, 0.71, and 0.74 for mRNA and C-index of 0.64, 0.68, and 0.69 for DNA methylation). Using RSF model, incorporating molecular data with clinical variables improved prediction of progression-free survival compared with using only clinical variables (p < 0.001 and p=0.008). Similarly, PDS enabled us to classify patients into high-risk and low-risk group, which resulted in survival difference in mRNA profiles (log-rank p-value=0.011). In external validation, gene signature was well correlated with prediction of lymphatic invasion and patients’ survival.
Conclusion
Molecular signature model predicting lymphatic invasion was well performed and also associated with survival of EOC patients. -
Citations
Citations to this article as recorded by- Identifying Stage II Colorectal Cancer Recurrence Associated Genes by Microarray Meta-Analysis and Building Predictive Models with Machine Learning Algorithms
Wei Lu, Xiang Pan, Siqi Dai, Dongliang Fu, Maxwell Hwang, Yingshuang Zhu, Lina Zhang, Jingsun Wei, Xiangxing Kong, Jun Li, Qian Xiao, Kefeng Ding, Quan Cheng
Journal of Oncology.2021; 2021: 1. CrossRef
- Identifying Stage II Colorectal Cancer Recurrence Associated Genes by Microarray Meta-Analysis and Building Predictive Models with Machine Learning Algorithms
- 10,224 View
- 249 Download
- 5 Web of Science
- 1 Crossref
- Light Alcohol Drinking and Risk of Cancer: A Meta-Analysis of Cohort Studies
- Yoon-Jung Choi, Seung-Kwon Myung, Ji-Ho Lee
- Cancer Res Treat. 2018;50(2):474-487. Published online May 22, 2017
- DOI: https://doi.org/10.4143/crt.2017.094
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
The purpose of this study was to determine whether light alcohol drinking increases the risk of cancer by using a meta-analysis of cohort studies because the newly revised 2015 European Code against Cancer fourth edition on alcohol and cancer was based on critical flaws in the interpretation and citation of the previous meta-analyses.
Materials and Methods
PubMed and EMBASE were searched in April, 2016. Two authors independently reviewed and selected cohort studies on the association between very light (≤ 0.5 drink/day), light (≤ 1 drink/day), or moderate drinking (1-2 drinks/day) and the risk of cancer incidence and mortality. A pooled relative riskwith its 95% confidence intervalwas calculated by a randomeffects meta-analysis. Main outcome measures were cancer incidence and mortality.
Results
A total of 60 cohort studies from 135 articles were included in the final analysis. Very light drinking or light drinking was not associated with the incidence of most cancers except for female breast cancer in women and male colorectal cancer. Conversely, light drinking was associated with a decreased incidence of both female and male lung cancer significantly and both female and male thyroid cancer marginally significantly. Moderate drinking significantly increased the incidence of male colorectal cancer and female breast cancer,whereas it decreased the incidence of both female and male hematologic malignancy.
Conclusion
We found that very light or light alcohol drinking was not associated with the risk of most of the common cancers except for the mild increase in the incidence of breast cancer in women and colorectal cancer in men. -
Citations
Citations to this article as recorded by- Lung Cancer and Lifestyle Factors
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- Pazopanib for the Treatment of Non-clear Cell Renal Cell Carcinoma: A Single-Arm, Open-Label, Multicenter, Phase II Study
- Ki Sun Jung, Su Jin Lee, Se Hoon Park, Jae-Lyun Lee, Se-Hoon Lee, Jae Yun Lim, Jung Hun Kang, Suee Lee, Sun Young Rha, Kyung Hee Lee, Ho Young Kim, Ho Yeong Lim
- Cancer Res Treat. 2018;50(2):488-494. Published online May 22, 2017
- DOI: https://doi.org/10.4143/crt.2016.584
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
The optimal treatment strategy for patients with metastatic non-clear cell type renal cell carcinoma (nccRCC) remains unclear. Although several inhibitors of vascular endothelial growth factor have recently shown efficacy against nccRCC, the clinical benefit of pazopanib in nccRCC has not been analyzed. We therefore designed a single-arm, open-label, phase II study to determine the efficacy and safety of pazopanib in patients with nccRCC.
Materials and Methods
Patientswith locally advanced or metastatic nccRCC, exceptfor collecting duct or sarcomatoid type, received 800 mg/day of pazopanib daily until progression of disease or intolerable toxicity. One cyclewas defined as 4weeks and tumorresponsewas evaluated every two cycles. The primary objective was overall response rate (ORR).
Results
A total of 29 eligible patients were enrolled at nine centers in Korea from December 2012 and September 2014. The median age of the patients was 58 years (range, 27 to 76 years) and 21 patients (72%) were male. Regarding histology type, 19 patients had papillary, three had chromophobe, two had unclassified and five had unknown non-clear cell type. Of 28 evaluable patients, eight achieved a confirmed partial response with ORR of 28%. The median progression-free survival was 16.5 months (95% confidence interval, 10.9 to 22.1) and median overall survival was not reached. Sixteen patients (55%) experienced treatment-related toxicity of grade 3 or more, but most adverse events were overcome through dose reduction and delay.
Conclusion
In this prospective phase II study, pazopanib demonstrated promising activity and tolerable safety profile in patients with metastatic nccRCC. -
Citations
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- ALK Protein Expression Is Related to Neuroblastoma Aggressiveness But Is Not Independent Prognostic Factor
- Ji Won Lee, Sung Hye Park, Hyoung Jin Kang, Kyung Duk Park, Hee Young Shin, Hyo Seop Ahn
- Cancer Res Treat. 2018;50(2):495-505. Published online May 22, 2017
- DOI: https://doi.org/10.4143/crt.2016.577
-
Abstract
PDFPubReaderePub
- Purpose
In this study, anaplastic lymphoma kinase (ALK) mutation and amplification, ALK protein expression, loss of the nuclear alpha thalassemia/mental retardation syndrome X-linked (ATRX) protein, and telomerase reverse transcriptase (TERT) protein expressionwere studied to investigate potential correlations between these molecular characteristics and clinical features or outcomes in neuroblastoma.
Materials and Methods
Seventy-two patients were enrolled in this study. Polymerase chain reaction amplification and direct sequencing were used for mutation analysis. ALK and MYCN amplifications were detected by fluorescence in situ hybridization. Protein expressionwas evaluated by immunohistochemical (IHC) staining.
Results
ALK mutation was found in only two patients (4.1%); ALK amplification was not detected. ALK positivity, loss of nuclear ATRX protein, TERT positivity by IHC were detected in 40 (55.6%), nine (13.0%), and 42 (59.2%) patients, respectively. The incidence of ALK expression increased in accordance with increasing tumor stage (p=0.001) and risk group (p < 0.001). The relapse rate was significantly higher in ALK+ patients compared to that of other patients (47.5% vs. 11.3%, p=0.007). However, there was no significant difference in relapse rate when the survival analysis was confined to the high-risk patients.
Conclusion
Although ALK mutation was rare and no amplification was observed, ALK protein expression was found in a significant number of patients and was correlated with advanced stage and high-risk neuroblastoma. ALK protein expression could be considered as a marker related to the aggressive neuroblastoma, but it was not the independent prognostic factor for the outcome. -
Citations
Citations to this article as recorded by- Immunohistochemical expression of anaplastic lymphoma kinase in neuroblastoma and its relations with some clinical and histopathological features
Thu Dang Anh Phan, Thao Quyen Nguyen, Nhi Thuy To, Thien Ly Thanh, Dat Quoc Ngo
Journal of Pathology and Translational Medicine.2024; 58(1): 29. CrossRef - Multi-omics revealed that ELAVL3 regulates MYCN in neuroblastoma via immunogenic cell death: Risk stratification and experimental research
Peng Hong, Zaihong Hu, Jie Lin, Kongkong Cui, Zhiqiang Gao, Xiaomao Tian, Qinlin Shi, Tao Lin, Guanghui Wei
International Journal of Biological Macromolecules.2024; 282: 137045. CrossRef - Prominent Staining of MYCN Immunohistochemistry Predicts a Poor Prognosis in MYCN Non-Amplified Neuroblastoma
Manli Zhao, Weizhong Gu, Fei Liu, Lihua Yu, Yan Shu, Lei Liu, Jiahui Hu, Yang Liu, Hongfeng Tang, Jianhua Mao
Pediatric and Developmental Pathology.2023; 26(2): 124. CrossRef - ALKGene Mutation and ALK Protein Expression in Advanced Neuroblastoma and the Potential Value in Risk Stratification in Fine-Needle Aspiration Biopsy Samples
Neha Bhardwaj, Manish Rohilla, Upasana Gautam, Amita Trehan, Deepak Bansal, Nandita Kakkar, Radhika Srinivasan
American Journal of Clinical Pathology.2023;[Epub] CrossRef - Rapid detection of telomerase expression of neuroblastoma in paraffin-embedded tissue: combination of in situ hybridisation and quantitative PCR
Manli Zhao, Zhonghai Guan, Liang Gong, Fei Liu, Weizhong Gu, Lei Liu, Kewen Jiang, Jiabin Cai, Chunyue Feng, Chik Hong Kuick, Kenneth Tou En Chang, Jinhu Wang, Hongfeng Tang, Minzhi Yin, Jianhua Mao
Pathology.2023; 55(7): 958. CrossRef - Interactions of Butyrylcholinesterase with Neuroblastoma-associated
Oncoproteins
Janina Baranowska-Kortylewicz, Zbigniew P. Kortylewicz, Erin M. McIntyre, John G. Sharp, Don W. Coulter
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Trupti Trivedi, Kinjal Panchal, Neha Bhalala, Priti Trivedi, Harsha Panchal
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Dinesh Babu Somasundaram, Sheeja Aravindan, Nandita Gupta, Zhongxin Yu, Ashley Baker, Natarajan Aravindan
World Journal of Pediatrics.2022; 18(4): 285. CrossRef - Multifarious Functions of Butyrylcholinesterase in Neuroblastoma: Impact of BCHE Deletion on the Neuroblastoma Growth In Vitro and In Vivo
Janina Baranowska-Kortylewicz, Zbigniew P. Kortylewicz, Erin M. McIntyre, John G. Sharp, Don W. Coulter
Journal of Pediatric Hematology/Oncology.2022; 44(6): 293. CrossRef - Differential Impact of ALK Mutations in Neuroblastoma
Tara O'Donohue, Nitya Gulati, Audrey Mauguen, Brian H. Kushner, Neerav Shukla, M. I. Rodriguez-Sanchez, Nancy Bouvier, Stephen Roberts, Ellen Basu, Nai-Kong Cheung, Shakeel Modak
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Daniel A. Morgenstern, Rochelle Bagatell, Susan L. Cohn, Michael D. Hogarty, John M. Maris, Lucas Moreno, Julie R. Park, Andrew D. Pearson, Gudrun Schleiermacher, Dominique Valteau‐Couanet, Wendy B. London, Meredith S. Irwin
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Ricky Trigg, Suzanne Turner
Cancers.2018; 10(4): 113. CrossRef
- Immunohistochemical expression of anaplastic lymphoma kinase in neuroblastoma and its relations with some clinical and histopathological features
- 10,118 View
- 364 Download
- 10 Web of Science
- 12 Crossref
- Redefining the Positive Circumferential Resection Margin by Incorporating Preoperative Chemoradiotherapy Treatment Response in Locally Advanced Rectal Cancer: A Multicenter Validation Study
- Joo Ho Lee, Eui Kyu Chie, Seung-Yong Jeong, Tae-You Kim, Dae Yong Kim, Tae Hyun Kim, Sun Young Kim, Ji Yeon Baek, Hee Jin Chang, Min Ju Kim, Sung Chan Park, Jae Hwan Oh, Sung Hwan Kim, Jong Hoon Lee, Doo Ho Choi, Hee Chul Park, Sung-Bum Kang, Jae-Sung Kim
- Cancer Res Treat. 2018;50(2):506-517. Published online May 24, 2017
- DOI: https://doi.org/10.4143/crt.2016.607
-
Abstract
PDFPubReaderePub
- Purpose
This study was conducted to validate the prognostic influence of treatment response among patients with positive circumferential resection margin for locally advanced rectal cancer.
Materials and Methods
Clinical data of 197 patientswith positive circumferentialresection margin defined as ≤ 2 mm after preoperative chemoradiotherapy followed by total mesorectal excision between 2004 and 2009were collected forthis multicenter validation study. All patients underwent median 50.4Gy radiationwith concurrentfluoropyrimidine based chemotherapy. Treatmentresponse was dichotomized to good response, including treatmentresponse of grade 2 or 3, and poor response, including grade 0 or 1.
Results
After 52 months median follow-up, 5-year overall survival (OS) for good responders and poor responders was 79.1% and 48.4%, respectively (p < 0.001). In multivariate analysis, circumferential resection margin involvement and treatment response were a prognosticator for OS and locoregional recurrence-free survival. In subgroup analysis, good responders with close margin showed significantly better survival outcomes for survival. Good responders with involved margin and poor responders with close margin shared similar results, whereas poorresponderswith involved margin hadworst survival (5-year OS, 81.2%, 57.0%, 50.0%, and 32.4%, respectively; p < 0.001).
Conclusion
Among patients with positive circumferential resection margin after preoperative chemoradiotherapy, survival of the good responders was significantly better than poor responders. Subgroup analysis revealed that definition of positive circumferential resection margin may be individualized as involvement for good responders, whereas ≤ 2 mm for poor responders. -
Citations
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- 266 Download
- 4 Web of Science
- 2 Crossref
- Phase II Study of Induction Chemotherapy with Docetaxel, Capecitabine, and Cisplatin Plus Bevacizumab for Initially Unresectable Gastric Cancer with Invasion of Adjacent Organs or Paraaortic Lymph Node Metastasis
- Jwa Hoon Kim, Sook Ryun Park, Min-Hee Ryu, Baek-Yeol Ryoo, Kyu-pyo Kim, Beom Su Kim, Moon-Won Yoo, Jeong Hwan Yook, Byung Sik Kim, Jihun Kim, Sun-Ju Byeon, Yoon-Koo Kang
- Cancer Res Treat. 2018;50(2):518-529. Published online May 24, 2017
- DOI: https://doi.org/10.4143/crt.2017.005
-
Abstract
PDFPubReaderePub
- Purpose
The purpose of this study was to evaluate the efficacy and safety of induction chemotherapy with docetaxel, capecitabine, and cisplatin (DXP) plus bevacizumab (BEV) on initially unresectable locally advanced gastric cancer (LAGC) or paraaortic lymph node (PAN) metastatic gastric cancer (GC).
Materials and Methods
Patients with LAGC or unresectable PAN metastatic GC received six induction chemotherapy cycles (60 mg/m2 docetaxel intravenously on day 1, 937.5 mg/m2 capecitabine orally twice daily on days 1-14, 60 mg/m2 cisplatin intravenously on day 1, and 7.5 mg/kg BEV intravenously on day 1 every 3 weeks), followed by conversion surgery. The primary endpoint was R0 resection rate.
Results
Thirty-one patients with invasion to adjacent organs but without PAN metastasis (n=14, LAGC group) or with PAN metastasis regardless of invasion (n=17, PAN group) were enrolled between July 2010 and December 2014. Twenty-seven patients (87.1%) completed six chemotherapy cycles. The most common grade ≥ 3 toxicities were neutropenia (71%), neutropenia with fever/infection (22.6%/3.2%), and stomatitis (16.1%). The clinical response and R0 resection rates were 64.3% (95% confidence interval [CI], 46.6 to 82.0) and 64.5% (LAGC group, 71.4%; PAN group, 58.8%), respectively. The pathological complete regression rate was 12.9%. After a median follow-up of 44.5 months (range, 39.4 to 49.7 months), the median progression-free survival and overall survival were 13.1 months (95% CI, 8.9 to 17.3) and 38.6 months (95% CI, 22.0 to 55.1), respectively.
Conclusion
Induction chemotherapy with DXP+BEV displayed antitumor activities with encouraging R0 resection rate and manageable toxicity profiles on patients with LAGC or PAN metastatic GC. -
Citations
Citations to this article as recorded by- Clinical Efficacy and Safety of Bevacizumab, Apatinib, and Recombinant Human Endothelial Inhibitor in the Treatment of Advanced Gastric Cancer
Liang Wang, Wei Li, Ya-Gang Liu, Cui Zhang, Wei-Na Gao, Li-Fei Gao, Wei long Zhong
Journal of Oncology.2022; 2022: 1. CrossRef - Neoadjuvant Bevacizumab Plus Docetaxel/Cisplatin/Capecitabine Chemotherapy in Locally Advanced Gastric Cancer Patients: A Pilot Study
Deguo Yu, Zhenfeng Wang, Tingbang He, Lijun Yang
Frontiers in Surgery.2022;[Epub] CrossRef - Research progress in targeted therapy and immunotherapy for gastric cancer
Xuewei Li, Jun Xu, Jun Xie, Wenhui Yang
Chinese Medical Journal.2022; 135(11): 1299. CrossRef - Novel Drug Delivery Method Targeting Para-Aortic Lymph Nodes by Retrograde Infusion of Paclitaxel into Pigs’ Thoracic Duct
Akira Saito, Natsuka Kimura, Yuji Kaneda, Hideyuki Ohzawa, Hideyo Miyato, Hironori Yamaguchi, Alan Kawarai Lefor, Ryozo Nagai, Naohiro Sata, Joji Kitayama, Kenichi Aizawa
Cancers.2022; 14(15): 3753. CrossRef - New therapeutic options opened by the molecular classification of gastric cancer
Mihaela Chivu-Economescu, Lilia Matei, Laura G Necula, Denisa L Dragu, Coralia Bleotu, Carmen C Diaconu
World Journal of Gastroenterology.2018; 24(18): 1942. CrossRef - Gastric cancer: Basic aspects
Henrique O. Duarte, Joana Gomes, José C. Machado, Celso A. Reis
Helicobacter.2018;[Epub] CrossRef
- Clinical Efficacy and Safety of Bevacizumab, Apatinib, and Recombinant Human Endothelial Inhibitor in the Treatment of Advanced Gastric Cancer
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- Body Composition Predicts Survival in Patients with Hepatocellular Carcinoma Treated with Transarterial Chemoembolization
- Neehar D. Parikh, Peng Zhang, Amit G. Singal, Brian A. Derstine, Venkat Krishnamurthy, Pranab Barman, Akbar K. Waljee, Grace L. Su
- Cancer Res Treat. 2018;50(2):530-537. Published online June 1, 2017
- DOI: https://doi.org/10.4143/crt.2017.156
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
The prognosis of patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) is often uncertain. We aimed to utilize analytic morphomics, a high-throughput imaging analysis, to assess if body composition is predictive of post-TACE survival.
Materials and Methods
We included patients from a single center (Ann Arbor VA)who had TACE as the primary treatment forHCC and had a pre-treatment computed tomography scans. Univariate analysis and multivariate conditional inference tree analysis were utilized to identify the morphomic characteristics predictive of 1-year survival. Resultswere validated in an external cohort(University of MichiganHealth System) ofHCC patientswho underwent TACE as their primary treatment.
Results
In the 75 patients in the derivation cohort, median survival was 439 (interquartile range, 377 to 685) days from receipt of TACE, with 1-year survival of 61%. Visceral fat density (VFD) was the only morphomic factor predictive of overall and 1-year survival (p < 0.001). Patients with VFD above the 56th percentile had a 1-year survival of 39% versus 78% for those below the 56th percentile. VFD also correlated with 1-year survival in the external validation cohort (44% vs. 72%, p < 0.001). In a secondary analysis, patients with higher VFD were significantly more likely to experience hepatic decompensation after TACE (p < 0.001).
Conclusion
VFD served as an objective predictor of mortality in patients undergoing TACE, possibly through its ability to predict hepatic decompensation. VFD may serve as a radiographic biomarker in predicting TACE outcomes. -
Citations
Citations to this article as recorded by- Artificial Intelligence and Machine Learning Predicting Transarterial Chemoembolization Outcomes: A Systematic Review
Elina En Li Cho, Michelle Law, Zhenning Yu, Jie Ning Yong, Claire Shiying Tan, En Ying Tan, Hirokazu Takahashi, Pojsakorn Danpanichkul, Benjamin Nah, Gwyneth Shook Ting Soon, Cheng Han Ng, Darren Jun Hao Tan, Yuya Seko, Toru Nakamura, Asahiro Morishita, S
Digestive Diseases and Sciences.2025; 70(2): 533. CrossRef - Impact of body composition on the prognosis of hepatocellular carcinoma patients treated with transarterial chemoembolization: A systematic review and meta-analysis
Anrong Wang, Junfeng Li, Changfeng Li, Hui Zhang, Yingfang Fan, Kuansheng Ma, Qiang Wang
Heliyon.2024; 10(3): e25237. CrossRef - Incorporation of quantitative imaging data using artificial intelligence improves risk prediction in veterans with liver disease
Grace L. Su, Peng Zhang, Patrick X. Belancourt, Bradley Youles, Binu Enchakalody, Ponni Perumalswami, Akbar Waljee, Sameer Saini
Hepatology.2024; 80(4): 928. CrossRef - Morphomics, Survival, and Metabolites in Patients With Metastatic Pancreatic Cancer
Valerie Gunchick, Edward Brown, Juan Liu, Jason W. Locasale, Philip A. Philip, Stewart C. Wang, Grace L. Su, Vaibhav Sahai
JAMA Network Open.2024; 7(10): e2440047. CrossRef - Role of tumor-specific and whole-body imaging biomarkers for prediction of recurrence in patients with stage III colorectal cancer
Amir A. Borhani, Peng Zhang, Brenda Diergaarde, Sophie Darwiche, Kalina Chuperlovska, Stewart C. Wang, Robert E. Schoen, Grace L. Su
Abdominal Radiology.2024; 50(5): 1907. CrossRef - Impact of sarcopenia on clinical outcomes for patients with resected hepatocellular carcinoma: a retrospective comparison of Eastern and Western cohorts
Berend R. Beumer, Kosei Takagi, Stefan Buettner, Yuzo Umeda, Takahito Yagi, Toshiyoshi Fujiwara, Jeroen L.A. van Vugt, Jan N.M. IJzermans
International Journal of Surgery.2023; 109(8): 2258. CrossRef - Clinical-radiomics predictors to identify the suitability of transarterial chemoembolization treatment in intermediate-stage hepatocellular carcinoma: A multicenter study
Dan-Dan Wang, Jin-Feng Zhang, Lin-Han Zhang, Meng Niu, Hui-Jie Jiang, Fu-Cang Jia, Shi-Ting Feng
Hepatobiliary & Pancreatic Diseases International.2023; 22(6): 594. CrossRef - Impact of body composition in advanced hepatocellular carcinoma: A subanalysis of the SORAMIC trial
Alexey Surov, Maximilian Thormann, Mattes Hinnerichs, Max Seidensticker, Ricarda Seidensticker, Osman Öcal, Kerstin Schütte, Christoph J. Zech, Christian Loewe, Otto van Delden, Vincent Vandecaveye, Chris Verslype, Bernhard Gebauer, Christian Sengel, Iren
Hepatology Communications.2023;[Epub] CrossRef - Adipose distribution patterns as prognostic factors in patients with HCC: A systematic review and meta-analysis
Shuo Shi, Haiyan Yi, Yi Zheng, Yuxuan Zhao, Dexin Yu
European Journal of Radiology.2023; 167: 111025. CrossRef - Preoperative Pectoralis Muscle Index Predicts Distant Metastasis-Free Survival in Breast Cancer Patients
Wen-juan Huang, Meng-lin Zhang, Wen Wang, Qing-chun Jia, Jia-rui Yuan, Xin Zhang, Shuang Fu, Yu-xi Liu, Shi-di Miao, Rui-tao Wang
Frontiers in Oncology.2022;[Epub] CrossRef - Metabolic abnormalities, liver and body fat in American versus Chinese patients with non‐alcoholic fatty liver disease
Wei Zhang, Grace L Su, Kaza Sravanthi, Rui Huang, Yi Wang, Huiying Rao, Lai Wei, Anna S Lok
JGH Open.2022; 6(8): 519. CrossRef - Impact of muscle mass on survival of patients with hepatocellular carcinoma after liver transplantation beyond the Milan criteria
Berend R. Beumer, Jeroen L.A. van Vugt, Gonzalo Sapisochin, Peter Yoon, Marco Bongini, Di Lu, Xiao Xu, Paolo De Simone, Lorenzo Pintore, Nicolas Golse, Malgorzata Nowosad, William Bennet, Emmanouil Tsochatzis, Evangelia Koutli, Fariba Abbassi, Marco P.A.W
Journal of Cachexia, Sarcopenia and Muscle.2022; 13(5): 2373. CrossRef - Bone Densities Assessed by Hounsfield Units at L5 in Computed Tomography Image Independently Predict Hepatocellular Carcinoma Development in Cirrhotic Patients
Christopher Yeh, Ming-Wei Lai, Chau-Ting Yeh, Yang-Hsiang Lin, Jeng-Hwei Tseng
Journal of Clinical Medicine.2022; 11(19): 5562. CrossRef - What Is the Role of Body Composition Assessment in HCC Management?
Pompilia Radu, Maryam Ebadi, Aldo J. Montano-Loza, Jean Francois Dufour
Cancers.2022; 14(21): 5290. CrossRef - High subcutaneous adipose tissue density correlates negatively with survival in patients with hepatocellular carcinoma
Leona von Hessen, Marie Roumet, Martin Helmut Maurer, Naomi Lange, Helen Reeves, Jean‐François Dufour, Pompilia Radu
Liver International.2021; 41(4): 828. CrossRef - Automated Measurements of Body Composition in Abdominal CT Scans Using Artificial Intelligence Can Predict Mortality in Patients With Cirrhosis
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Hepatology Communications.2021; 5(11): 1901. CrossRef - The role of muscle depletion and visceral adiposity in HCC patients aged 65 and over undergoing TACE
Jihye Lim, Kyung Won Kim, Yousun Ko, Il-Young Jang, Yung Sang Lee, Young-Hwa Chung, Han Chu Lee, Young-Suk Lim, Kang Mo Kim, Ju Hyun Shim, Jonggi Choi, Danbi Lee
BMC Cancer.2021;[Epub] CrossRef - Morphomic Signatures Derived from Computed Tomography Predict Hepatocellular Carcinoma Occurrence in Cirrhotic Patients
Kung-Hao Liang, Peng Zhang, Chih-Lang Lin, Stewart C. Wang, Tsung-Hui Hu, Chau-Ting Yeh, Grace L. Su
Digestive Diseases and Sciences.2020; 65(7): 2130. CrossRef - Visceral Adipose Tissue Radiodensity Is Linked to Prognosis in Hepatocellular Carcinoma Patients Treated with Selective Internal Radiation Therapy
Maryam Ebadi, Carlos Moctezuma-Velazquez, Judith Meza-Junco, Vickie E. Baracos, Abha R. DunichandHoedl, Sunita Ghosh, Philippe Sarlieve, Richard J. Owen, Norman Kneteman, Aldo J. Montano-Loza
Cancers.2020; 12(2): 356. CrossRef - Review article: prognostic significance of body composition abnormalities in patients with cirrhosis
Maryam Ebadi, Rahima A. Bhanji, Puneeta Tandon, Vera Mazurak, Vickie E. Baracos, Aldo J. Montano‐Loza
Alimentary Pharmacology & Therapeutics.2020; 52(4): 600. CrossRef - Sarcopenia Severity Based on Computed Tomography Image Analysis in Patients with Cirrhosis
Maryam Ebadi, Rahima A. Bhanji, Abha R. Dunichand-Hoedl, Vera C. Mazurak, Vickie E. Baracos, Aldo J. Montano-Loza
Nutrients.2020; 12(11): 3463. CrossRef - Fat Accumulation, Liver Fibrosis, and Metabolic Abnormalities in Chinese Patients With Moderate/Severe Versus Mild Hepatic Steatosis
Wei Zhang, Rui Huang, Yi Wang, Huiying Rao, Lai Wei, Grace L. Su, Anna S. Lok
Hepatology Communications.2019; 3(12): 1585. CrossRef - Predicting Survival Using Pretreatment CT for Patients With Hepatocellular Carcinoma Treated With Transarterial Chemoembolization: Comparison of Models Using Radiomics
Jonghoon Kim, Seung Joon Choi, Seung-Hak Lee, Ho Yun Lee, Hyunjin Park
American Journal of Roentgenology.2018; 211(5): 1026. CrossRef - Carcinogenesis on the background of liver fibrosis: Implications for the management of hepatocellular cancer
Joanne Marie O’Rourke, Vandana Mridhu Sagar, Tahir Shah, Shishir Shetty
World Journal of Gastroenterology.2018; 24(39): 4436. CrossRef - The Adverse Impact of Sarcopenia and Visceral Fat Deposition on the Course of Hepatocellular Carcinoma and the Role of Nutritional Interventions
Adam McCulloch, Hardip Malhi, Amritpal Dhaliwal, Sheldon Cooper, Tahir Shah
European Medical Journal.2018; : 126. CrossRef
- Artificial Intelligence and Machine Learning Predicting Transarterial Chemoembolization Outcomes: A Systematic Review
- 10,863 View
- 224 Download
- 26 Web of Science
- 25 Crossref
- Declined Preoperative Aspartate Aminotransferase to Neutrophil Ratio Index Predicts Poor Prognosis in Patients with Intrahepatic Cholangiocarcinoma after Hepatectomy
- Lingyun Liu, Wei Wang, Yi Zhang, Jianting Long, Zhaohui Zhang, Qiao Li, Bin Chen, Shaoqiang Li, Yunpeng Hua, Shunli Shen, Baogang Peng
- Cancer Res Treat. 2018;50(2):538-550. Published online June 1, 2017
- DOI: https://doi.org/10.4143/crt.2017.106
-
Abstract
PDFPubReaderePub
- Purpose
Various inflammation-based prognostic biomarkers such as the platelet to lymphocyte ratio and neutrophil to lymphocyte ratio, are related to poor survival in patients with intrahepatic cholangiocarcinoma (ICC). This study aims to investigate the prognostic value of the aspartate aminotransferase to neutrophil ratio index (ANRI) in ICC after hepatic resection.
Materials and Methods
Data of 184 patients with ICC after hepatectomy were retrospectively reviewed. The cut-off value of ANRIwas determined by a receiver operating characteristic curve. Preoperative ANRI and clinicopathological variables were analyzed. The predictive value of preoperative ANRI for prognosis of ICC was identified by univariate and multivariate analyses.
Results
The optimal cut-off value of ANRI was 6.7. ANRI was associated with tumor size, tumor recurrence, white blood cell, neutrophil count, aspartate aminotransferase, and alanine transaminase. Univariate analysis showed that ANRI, sex, tumor number, tumor size, tumor differentiation, lymph node metastasis, resection margin, clinical TNM stage, neutrophil count, and carcinoembryonic antigen were markedly correlated with overall survival (OS) and disease-free survival (DFS) in patients with ICC. Multivariable analyses revealed that ANRI, a tumor size > 6 cm, poor tumor differentiation, and an R1 resection margin were independent prognostic factors for both OS and DFS. Additionally, preoperative ANRI also had a significant value to predict prognosis in various subgroups of ICC, including serum hepatitis B surface antigen‒negative and preoperative elevated carbohydrate antigen 19-9 patients.
Conclusion
Preoperative declined ANRI is a noninvasive, simple, and effective predictor of poor prognosis in patients with ICC after hepatectomy. -
Citations
Citations to this article as recorded by- Predictive model for non-malignant portal vein thrombosis associated with cirrhosis based on inflammatory biomarkers
Guo-Le Nie, Jun Yan, Ying Li, Hong-Long Zhang, Dan-Na Xie, Xing-Wang Zhu, Xun Li
World Journal of Gastrointestinal Oncology.2024; 16(4): 1213. CrossRef - An Analysis of the Factors Influencing Disease-Free and Overall Survival Time after Curative Resection for Hepatocellular Carcinoma
琪栋 陈
Advances in Clinical Medicine.2024; 14(04): 2267. CrossRef - The preoperative scoring system combining neutrophil/lymphocyte ratio and CA19-9 predicts the long-term prognosis of intrahepatic cholangiocarcinoma patients undergoing curative liver resection
Shilei Bai, Xiaodong Shi, Yizhe Dai, Huifeng Wang, Yong Xia, Jian Liu, Kui Wang
BMC Cancer.2024;[Epub] CrossRef - Multifaceted roles of neutrophils in tumor microenvironment
Xueyin Pan, Qiang Wang, Beicheng Sun
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2024; 1879(6): 189231. CrossRef - Development and validation of prognostic nomograms based on De Ritis ratio and clinicopathological features for patients with stage II/III colorectal cancer
Jinming Fu, Fenqi Du, Tian Tian, Hao Huang, Lei Zhang, Dapeng Li, Yupeng Liu, Ding Zhang, Lijing Gao, Ting Zheng, Yanlong Liu, Yashuang Zhao
BMC Cancer.2023;[Epub] CrossRef - Hepatitis B virus-related intrahepatic cholangiocarcinoma originates from hepatocytes
Zimin Song, Shuirong Lin, Xiwen Wu, Xiaoxue Ren, Yifan Wu, Haoxiang Wen, Baifeng Qian, Haozhong Lin, Yihao Huang, Chenfeng Zhao, Nian Wang, Yan Huang, Baogang Peng, Xiaoxing Li, Hong Peng, Shunli Shen
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Shuirong Lin, Zimin Song, Hong Peng, Baifeng Qian, Haozhong Lin, Xiwen Wu, Huilong Li, Yunpeng Hua, Baogang Peng, Changzhen Shang, Ming Kuang, Shunli Shen
Surgery.2023; 174(4): 865. CrossRef - The Prognostic Value of Multiple Systemic Inflammatory Biomarkers in Preoperative Patients With Non-small Cell Lung Cancer
Kai Wang, Qidi Zhao, Tao Yan, Deyu Guo, Jichang Liu, Guanghui Wang, Jiajun Du
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Hui Li, Rongqiang Liu, Jiawang Li, Jiaxin Li, Hong Wu, Genshu Wang, Zhenhua Li, Dewei Li
Journal of Cellular and Molecular Medicine.2022; 26(11): 3196. CrossRef - AST·MLR index and operation injury condition are novel prognostic predictor for the prediction of survival in patients with colorectal cancer liver metastases undergoing surgical resection
Qichen Chen, Mingxia Li, Jinghua Chen, Zhen Huang, Xiao Chen, Hong Zhao, Jianqiang Cai
BMC Cancer.2022;[Epub] CrossRef - Nomogram Based on Inflammatory Biomarkers to Predict the Recurrence of Hepatocellular Carcinoma—A Multicentre Experience
Zehao Zheng, Renguo Guan, Yiping Zou, Zhixiang Jian, Ye Lin, Rongping Guo, Haosheng Jin
Journal of Inflammation Research.2022; Volume 15: 5089. CrossRef - Can the De Ritis Ratio (AST/ALT) be used to predict colon cancer stages?
Saygın ALTINER, Enes CEBECİ, Bedri Burak SUCU, Mert ÇÖL, Ender ERGÜDER, Yılmaz ÜNAL, Salih TUNCAL, Mevlüt Recep PEKCİCİ
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Dong Huang, Huan Yang, He Yu, Ting Wang, Zhu Chen, Rong Yao, Zongan Liang
The American Journal of the Medical Sciences.2021; 362(4): 387. CrossRef - Is Aspartate Aminotransferase to Alanine Aminotransferase (De Ritis Ratio) Helpful in Predicting Breast Cancer?
Abdullah DURHAN, Abdullah ŞENLİKCİ, Ender ERGÜDER, Marlen SÜLEYMAN, Koray KOŞMAZ, Ümit MERCAN, Mevlüt Recep PEKCİCİ, Serap EREL
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Junjie Kong, Shu Shen, Zifei Zhang, Wentao Wang
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Charupong Saengboonmee, Kanlayanee Sawanyawisuth, Yaovalux Chamgramol, Sopit Wongkham
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Aging.2018; 10(12): 4120. CrossRef
- Predictive model for non-malignant portal vein thrombosis associated with cirrhosis based on inflammatory biomarkers
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- Evaluation of the Benefit of Radiotherapy in Patients with Occult Breast Cancer: A Population-Based Analysis of the SEER Database
- Byoung Hyuck Kim, Jeanny Kwon, Kyubo Kim
- Cancer Res Treat. 2018;50(2):551-561. Published online June 1, 2017
- DOI: https://doi.org/10.4143/crt.2017.189
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Few studies for occult breast cancer (OBC) have evaluated the effect of radiotherapy (RT) after mastectomy or axillary lymph node dissection (ALND) with/without breast surgery. Therefore, we investigated clinicopathologic factors of OBC with the impact of postoperative RT to determine its prognostic significance using large population-based data.
Materials and Methods
We performed a retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) database from 1983 to 2013. A total of 1,045 eligible patients with OBC were identified. We compared overall survival (OS) using Cox proportional hazards regression with propensity score matching after verifying an imbalance of prognosticators between RT group (n=518) and non-RT group (n=479).
Results
Patients with age < 70 (p=0.033), married marital status (p < 0.001), undergoing ALND (p < 0.001), more examined lymph nodes (LNs) (p < 0.001), and more metastatic LNs (p < 0.001) were more likely to receive RT. Multivariate analysis after propensity score matching (n=798) showed that patients treated with RT survived significantly longer than those without RT (5-year OS, 81.5% vs. 78.3%; p=0.014). A significantly prolonged OS was observed when RT was given to patients treated with mastectomy (p=0.033), those treated with ALND (p=0.036), or those with more than seven metastatic LNs (p=0.016).
Conclusion
RT may offer survival benefit in OBC even after mastectomy or ALND, especially in patients with more than seven metastatic LNs. Further prospective studies are needed to validate these findings. -
Citations
Citations to this article as recorded by- Occult breast cancer in an older woman: A case report
Cong Liu, Hua Xing
Experimental and Therapeutic Medicine.2024;[Epub] CrossRef - Reconceptualizing the clinicopathological features, locoregional therapy and prognostic factors of occult breast cancer in the era of molecular subtyping
Xin Ye, Li Yang, Qi He, Xiaoyan Lin, Jie Wang, Rongrong Cui, Cheng Xu
Women & Health.2023; 63(2): 105. CrossRef - Prognostic Models Using Machine Learning Algorithms and Treatment Outcomes of Occult Breast Cancer Patients
Jingkun Qu, Chaofan Li, Mengjie Liu, Yusheng Wang, Zeyao Feng, Jia Li, Weiwei Wang, Fei Wu, Shuqun Zhang, Xixi Zhao
Journal of Clinical Medicine.2023; 12(9): 3097. CrossRef - Best treatment options for occult breast cancer: A meta-analysis
Rong Wang, Hong-xin Yang, Jie Chen, Jian-jun Huang, Qing Lv
Frontiers in Oncology.2023;[Epub] CrossRef - Occult Breast Cancer Patients with Mastectomy have Better Prognosis than those with Breast-Conserving Therapy
Jiayi Li, Gang Liu, Ziqi Jia, Fei Ren, Dawei Dong, Menglu Zhang, Xiang Wang, Yipeng Wang
Future Oncology.2023; 19(36): 2405. CrossRef - Surgical treatment trends and identification of primary breast tumors after surgery in occult breast cancer: a study based on the Japanese National Clinical Database—Breast Cancer Registry
Mitsuo Terada, Minoru Miyashita, Hiraku Kumamaru, Hiroaki Miyata, Kenji Tamura, Masayuki Yoshida, Etsuyo Ogo, Masayuki Nagahashi, Sota Asaga, Yasuyuki Kojima, Takayuki Kadoya, Kenjiro Aogi, Naoki Niikura, Kotaro Iijima, Naoki Hayashi, Makoto Kubo, Yutaka
Breast Cancer.2022; 29(4): 698. CrossRef - Occult Breast Cancer Presented with Axillary Lymph Node Metastases: A Small Case Series to a Frustrating Medical Issue
D. Mantas, Z. Garoufalia, C. Kontzoglou
Indian Journal of Surgery.2021; 83(S2): 364. CrossRef - Treatment for occult breast cancer: A propensity score analysis of the National Cancer Database
Catherine Tsai, Beiqun Zhao, Theresa Chan, Sarah L. Blair
The American Journal of Surgery.2020; 220(1): 153. CrossRef - Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRI
Haeyoung Kim, Won Park, Su Ssan Kim, Sung Ja Ahn, Yong Bae Kim, Tae Hyun Kim, Jin Hee Kim, Jin-Hwa Choi, Hae Jin Park, Jee Suk Chang, Doo Ho Choi
The Breast.2020; 49: 63. CrossRef - Breast-Conserving Surgery in Patients With Mammary Paget's Disease
Yufeng Yao, Li Sun, Yan Meng, Yan Zhuang, Lin Zhao, Qiao Yu, Chengshuai Si
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Wenjie Shi, Youhong Luo, Dongkang Zhao, Hao Huang, Weiyi Pang
Oncology Letters.2019;[Epub] CrossRef
- Occult breast cancer in an older woman: A case report
- 10,825 View
- 365 Download
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- The Role of Consolidation Chemoradiotherapy in Locally Advanced Pancreatic Cancer Receiving Chemotherapy: An Updated Systematic Review and Meta-Analysis
- Jeffrey S. Chang, Yen-Feng Chiu, Jih-Chang Yu, Li-Tzong Chen, Hui-Ju Ch’ang
- Cancer Res Treat. 2018;50(2):562-574. Published online June 9, 2017
- DOI: https://doi.org/10.4143/crt.2017.105
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
The role of consolidation chemoradiation (CCRT) after systemic chemotherapy in locally advanced pancreatic cancer (LAPC) is still controversial. We aim to evaluate the effectiveness of CCRT in LAPC using systematic review and meta-analysis of prospective studies.
Materials and Methods
Prospective clinical trials of LAPC receiving chemotherapy with or without subsequent CCRT were included in the analysis. We systematically searched in PubMed, MEDLINE, Embase, and Web of Science. The primary outcome of interest was 1-year survival. Secondary endpoints were median overall survival, progression-free survival, toxicity, and resection rate.
Results
Forty-one studies with 49 study arms were included with a total of 1,018 patients receiving CCRT after induction chemotherapy (ICT) and 954 patients receiving chemotherapy alone. CCRT after ICT did not improve 1-year survival significantly in LAPC patients compared with chemotherapy alone (58% vs. 52%). ICT lasted for at least 3 months revealed significantly improved survival of additional CCRT to LAPC patients compared to chemotherapy alone (65% vs. 52%). A marginal survival benefit of consolidation CCRT was noted in studies using maintenance chemotherapy (59% vs. 52%), and fluorouracil-based CCRT (64% vs. 52%), as well as in studies conducted after the 2010 (64% vs. 55%).
Conclusion
The survival benefit of ICT+CCRT over chemotherapy alone in treating LAPC was noted when ICT lasted for at least 3 months. Fluorouracil-based CCRT, and maintenance chemotherapy were associated with improved clinical outcomes. -
Citations
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Peng Tang, Junfeng Zhang, Qiang Zhou, Wenmin Yi, Huaizhi Wang
Pancreas.2025; 54(3): e246. CrossRef - Total Neoadjuvant Therapy in Localized Pancreatic Cancer: Is More Better?
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- Effect of Radiotherapy in Neoadjuvant Treatment of Borderline Resectable and Locally Advanced Pancreatic Cancer
- 13,243 View
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- Low-Dose Radiation Therapy for Primary Conjunctival Marginal Zone B-Cell Lymphoma
- Ga-In Lee, Dongryul Oh, Won Seog Kim, Seok Jin Kim, Young Hyeh Ko, Kyung In Woo, Yoon-Duck Kim, Yong Chan Ahn
- Cancer Res Treat. 2018;50(2):575-581. Published online June 16, 2017
- DOI: https://doi.org/10.4143/crt.2017.182
-
Abstract
PDFPubReaderePub
- Purpose
The purpose of this study was to evaluate the clinical features and the long-term outcomes of primary conjunctival marginal zone B-cell lymphoma (MZBCL) patients who were treated with radiation therapy (RT).
Materials and Methods
Retrospective data of 79 patients with 121 primary conjunctival MZBCL lesions were collected from January 1, 2001 till June 30, 2014. All lesions were treated by local RT (26 Gy) with patient-specific customized lens-shielding device.
Results
The current Korean patients’ cohort showed younger median age at diagnosis (38 years), great female preponderance (78.5%) and more frequent bilateral involvement (53.2%) than the previous studies. Following 26 Gy’s RT, excellent clinical outcomes were achieved: 5-year rates of overall survival, local relapse-free survival, and contralateral relapse-free survival were 100%, 98.1%, and 91.5%, respectively. Two patients (2.5%) developed local relapse and five (6.3%) developed relapse at initially uninvolved contralateral conjunctiva with median interval of 52.9 months, and late adverse events of grade 2 and 3 occurred in seven (8.8%) and two (2.5%) patients, respectively.
Conclusion
26 Gy’s RT was highly effective and safe, with the use of lens-shielding device, in treating patients with primary conjunctival MZBCL. -
Citations
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Jaeha Lee, Si Yeol Song, Young Seob Shin, Sung-Woo Kim, Ye Jin Yoo, Ji Hyeon Joo, Ho-Seok Sa, Dok Hyun Yoon, Sang-wook Lee
Leukemia & Lymphoma.2025; : 1. CrossRef - Clinicopathologic features of conjunctival MALT lymphomas refractory to radiation therapy
Yuka Suimon, Satoru Kase, Rumiko Kinoshita, Susumu Ishida
Canadian Journal of Ophthalmology.2024; 59(5): e501. CrossRef - Long‐term outcomes of patients with conjunctival extranodal marginal zone lymphoma
Eduardo Edelman Saul, Juan Pablo Alderuccio, Isildinha M. Reis, Wei Zhao, Sunil G. Iyer, Gregor Rodriguez, Amrita Desai, Jennifer R. Chapman, David T. Tse, Arnold M. Markoe, Derek M. Isrow, Izidore S. Lossos
American Journal of Hematology.2023; 98(1): 148. CrossRef - Conjunctival Lymphoma
Lindsay A. McGrath, David A. Ryan, Sunil K. Warrier, Sarah E. Coupland, William J. Glasson
Eye.2023; 37(5): 837. CrossRef - Long‐term survival outcomes of patients with primary ocular adnexal MALT lymphoma: A large single‐center cohort study
Yuanzheng Liang, Rui‐ying Fu, Xue‐lin Liu, Xin‐di Liu, Ying‐shi Piao, Jian‐min Ma, Liang Wang
Cancer Medicine.2023; 12(3): 2514. CrossRef - Watchful waiting is an acceptable treatment option for asymptomatic primary ocular adnexal mucosa‐associated lymphoid tissue lymphoma: A retrospective study
Kentaro Mizuhara, Tsutomu Kobayashi, Mitsushige Nakao, Ryoichi Takahashi, Hiroto Kaneko, Kazuho Shimura, Koichi Hirakawa, Nobuhiko Uoshima, Katsuya Wada, Eri Kawata, Reiko Isa, Takahiro Fujino, Taku Tsukamoto, Shinsuke Mizutani, Yuji Shimura, Akiko Yoneda
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旭霞 李
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- Effectiveness of Gastric Cancer Screening on Gastric Cancer Incidence and Mortality in a Community-Based Prospective Cohort
- Heewon Kim, Yunji Hwang, Hokyung Sung, Jieun Jang, Choonghyun Ahn, Sang Gyun Kim, Keun-Young Yoo, Sue K. Park
- Cancer Res Treat. 2018;50(2):582-589. Published online June 9, 2017
- DOI: https://doi.org/10.4143/crt.2017.048
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
This study was performed to investigate the effectiveness of gastric cancer (GC) screening methods in a community-based prospective cohort of the Korean Multi-center Cancer Cohort (KMCC) with over a 10-year follow-up.
Materials and Methods
A total 10,909 and 4,773 subjects from the KMCC with information on gastroendoscopy (GE) and upper gastrointestinal series (UGIS) were included in this study. Cox proportional hazard model adjusted for age, sex, Helicobacter pylori infection, cigarette smoking, and alcohol drinking was used to estimate the hazard ratios (HRs) and 95% confidence interval (CI).
Results
The GE screened subjects had almost half the risk of GC-specific death than that of unscreened subjects (HR, 0.58; 95% CI, 0.36 to 0.94). Among the GC patients, GE screenees had a 2.24-fold higher survival rate than that of the non-screenees (95% CI, 1.61 to 3.11). In particular, GE screenees who underwent two or more screening episodes had a higher survival rate than that of the non-screenees (HR, 13.11; 95% CI, 7.38 to 23.30). The effectiveness of GE screening on reduced GC mortality and increased survival rate of GC patients was better in elderly subjects (≥ 65 years old) (HR, 0.47; 95% CI, 0.24 to 0.95 and HR, 8.84; 95% CI, 3.63 to 21.57, respectively) than that in younger subjects (< 65 years old) (HR, 0.66; 95% CI, 0.34 to 1.29 and HR, 1.83; 95% CI, 1.24 to 2.68, respectively). In contrast, UGIS screening had no significant relation to GC mortality and survival.
Conclusion
The findings of this study suggest that a decreased GC-specific mortality and improved survival rate in GC patients can be achieved through GE screening. -
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Hai‐Fan Xiao, Shi‐Peng Yan, Ji‐Gang Li, Zhao‐Hui Shi, Yan‐Hua Zou, Ke‐Kui Xu, Xian‐Zhen Liao
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Syn Yi Chong, Soo Fan Ang
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Hongmei Zeng, Kexin Sun, Maomao Cao, Rongshou Zheng, Xibin Sun, Shuzheng Liu, Zhiyi Zhang, Yuqin Liu, Guizhou Guo, Guohui Song, Yigong Zhu, Xianghong Wu, Bingbing Song, Xianzhen Liao, Yanfang Chen, Mingyang Song, Edward Giovannucci, Guihua Zhuang, Wenqian
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Jung-Hwan Oh, Mun-Gan Rhyu, Suk-Il Kim, Mi-Ri Yun, Jung-Ha Shin, Seung-Jin Hong
Cancer Research and Treatment.2019; 51(1): 267. CrossRef - Gastric Cancer – From Aetiology to Management: Differences Between the East and the West
W.L. Chan, K.O. Lam, V.H.F. Lee, M. Davidson, T.H. So, J.S. Li, I. Chau, D.L.W. Kwong
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Chang Seok Bang, Gwang Ho Baik
The Korean Journal of Internal Medicine.2019; 34(4): 772. CrossRef - Review and Comparison of Cancer Biomarker Trends in Urine as a Basis for New Diagnostic Pathways
Carmen Bax, Beatrice Julia Lotesoriere, Selena Sironi, Laura Capelli
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Qi Liu, Xi Zeng, Wen Wang, Ruo-lin Huang, Yan-jin Huang, Shan Liu, Ying-hui Huang, Ying-xin Wang, Qing-hong Fang, Guoping He, Ying Zeng
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Min-Seung Gwak, Jong-Min Park
Korean Journal of Clinical Oncology.2018; 14(2): 69. CrossRef
- Sedated and unsedated gastroscopy has no influence on the outcomes of patients with gastric cancer: a retrospective study
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- Multicenter Retrospective Analysis of Clinical Characteristics, Treatment Patterns, and Outcomes in Very Elderly Patients with Diffuse Large B-Cell Lymphoma: The Korean Cancer Study Group LY16-01
- Jung Hye Choi, Tae Min Kim, Hyo Jung Kim, Sung Ae Koh, Yeung-Chul Mun, Hye Jin Kang, Yun Hwa Jung, Hyeok Shim, So Young Chong, Der-Sheng Sun, Soonil Lee, Byeong Bae Park, Jung Hye Kwon, Seung-Hyun Nam, Jun Ho Yi, Young Jin Yuh, Jong-Youl Jin, Jae Joon Han, Seok-Hyun Kim
- Cancer Res Treat. 2018;50(2):590-598. Published online June 9, 2017
- DOI: https://doi.org/10.4143/crt.2017.172
-
Abstract
PDFPubReaderePub
- Purpose
The treatment strategy for elderly patients older than 80 years with diffuse large B-cell lymphoma (DLBCL) has not been established because of poor treatment tolerability and lack of data.
Materials and Methods
This multicenter retrospective study was conducted to investigate clinical characteristics, treatment patterns and outcomes of patients older than 80 years who were diagnosed with DLBCL at 19 institutions in Korea between 2005 and 2016.
Results
A total of 194 patients were identified (median age, 83.3 years). Of these, 114 patients had an age-adjusted International Prognostic Index (aaIPI) score of 2-3 and 48 had a Charlson index score of 4 or more. R-CHOP was given in 124 cases, R-CVP in 13 cases, other chemotherapy in 17 cases, radiation alone in nine cases, and surgery alone in two cases. Twenty-nine patients did not undergo any treatment. The median number of chemotherapy cycles was three. Only 37 patients completed the planned treatment cycles. The overall response rate from 105 evaluable patientswas 90.5% (complete response, 41.9%). Twentynine patients died due to treatment-related toxicities (TRT). Thirteen patients died due to TRT after the first cycle. Median overall survival was 14.0 months. The main causes of death were disease progression (30.8%) and TRT (27.1%). In multivariate analysis, overall survival was affected by aaIPI, hypoalbuminemia, elevated creatinine, and treatment.
Conclusion
Age itself should not be a contraindication to treatment. However, since elderly patients show higher rates of TRT due to infection, careful monitoring and dose modification of chemotherapeutic agents is needed. -
Citations
Citations to this article as recorded by- Treatment Patterns and Costs Among US Patients With Diffuse Large B-Cell Lymphoma not Treated With 2L Stem Cell Transplantation
Teofilia Acheampong, Tao Gu, Trong Kim Le, Scott J Keating
Future Oncology.2024; 20(10): 623. CrossRef - Identification of independent risk factors for hypoalbuminemia in patients with CKD stages 3 and 4: the construction of a nomogram
Chong-Hui Wang, Meng-Han Jiang, Ji-Min Ma, Ming-Cong Yuan, Lei Liao, Hao-Zhang Duan, Dan Wang, Lian Duan
Frontiers in Nutrition.2024;[Epub] CrossRef - TRAIL Score: A Simple Model to Predict Immunochemotherapy Tolerability in Patients With Diffuse Large B-Cell Lymphoma
Will Harris, Edward J. Bataillard, Yoonha Choi, Tarec C. El-Galaly, Vaikunth Cuchelkar, Carsten Henneges, Antonia Kwan, Daniel J. Schneider, Joseph N. Paulson, Tina G. Nielsen
JCO Clinical Cancer Informatics.2022;[Epub] CrossRef - A Multicenter Study of 239 Patients Aged Over 70 Years With Diffuse Large B-Cell Lymphoma in China
Chunli Yang, Qiaoer Li, Ke Xie, Yakun Zhang, Dania Xiang, Yunwei Han, Liqun Zou
Frontiers in Pharmacology.2022;[Epub] CrossRef - Cachexia index as a potential biomarker for cancer cachexia and a prognostic indicator in diffuse large B‐cell lymphoma
Se‐Il Go, Mi Jung Park, Sungwoo Park, Myoung Hee Kang, Hoon‐Gu Kim, Jung Hun Kang, Jung Hoon Kim, Gyeong‐Won Lee
Journal of Cachexia, Sarcopenia and Muscle.2021; 12(6): 2211. CrossRef - Treatment approaches for older and oldest patients with diffuse large B-cell lymphoma – Use of non-R-CHOP alternative therapies and impact of comorbidities on treatment choices and outcome: A Humedica database retrospective cohort analysis, 2007–2015
Vicki A. Morrison, Laurie Hamilton, Augustina Ogbonnaya, Aditya Raju, Kristin Hennenfent, Aaron Galaznik
Journal of Geriatric Oncology.2020; 11(1): 41. CrossRef - Clinical characteristics, treatment patterns and outcomes of patients older than 80 years diagnosed with DLBCL in China over a 10-year period
Zhan Shi, Xi Tang, Qianwen Shen, Jiayan Chen, Fei Liu, Xi Chen, Jingwen Wang, Jie Zhuang
Cancer Chemotherapy and Pharmacology.2019; 84(1): 127. CrossRef - Antineoplastics
Reactions Weekly.2018; 1701(1): 32. CrossRef
- Treatment Patterns and Costs Among US Patients With Diffuse Large B-Cell Lymphoma not Treated With 2L Stem Cell Transplantation
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- 8 Web of Science
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- Crizotinib in Combination with Everolimus Synergistically Inhibits Proliferation of Anaplastic Lymphoma Kinase‒Positive Anaplastic Large Cell Lymphoma
- Wendan Xu, Ji-Won Kim, Woo June Jung, Youngil Koh, Sung-Soo Yoon
- Cancer Res Treat. 2018;50(2):599-613. Published online June 19, 2017
- DOI: https://doi.org/10.4143/crt.2016.357
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Anaplastic large cell lymphoma (ALCL) is a rare aggresive non-Hodgkin lymphoma, of which over 50% of cases have an aberrant nucleophosmin (NPM)‒anaplastic lymphoma kinase (ALK) fusion protein. Both mechanistic target of rapamycin (mTOR) inhibitor everolimus and ALK inhibitor crizotinib have shown promising antitumor activity in ALK-positive cancer cell lines. However, their combined effect has not yet been investigated.
Materials and Methods
We evaluated the anti-proliferative effects of everolimus and/or crizotinib in ALK-positive ALCL cell lines, Karpas 299 and SU-DHL-1, and lung adenocarcinoma cell line, NCI-H2228.
Results
We found that individually, both everolimus and crizotinib potently inhibited cell growth in a dose-dependent manner in both Karpas 299 and SU-DHL-1 cells. A combination of these agents synergistically inhibited proliferation in the two cell lines. Crizotinib down-regulated aberrant AKT and ERK phosphorylation induced by everolimus. Combination treatment also significantly increased G0/G1 cell-cycle arrest, DNA damage, and apoptosis compared with everolimus or crizotinib alone in ALK-positive ALCL cells. In the Karpas 299 xenograft model, the combination treatment exerted a stronger antitumor effect than monotherapies, without significant change in body weight. The synergistic effect of everolimus and crizotinib was also reproduced in the ALK-positive lung adenocarcinoma cell line NCI-H2228. The combination treatment abrogated phosphoinositide 3-kinase/AKT and mTOR signaling pathways with little effect on the Ras/ERK pathway in NCI-H2228 cells.
Conclusion
Crizotinib combinedwith everolimus synergistically inhibits proliferation of ALK-positive ALCL cells. Our results suggest that this novel combination is worthy of further clinical development in patients with ALK-positive ALCL. -
Citations
Citations to this article as recorded by- The PI3K signaling pathway; from normal lymphopoiesis to lymphoid malignancies
Bahareh Kashani, Zahra Zandi, Atieh Pourbagheri‑Sigaroodi, Amir-Mohammad Yousefi, Seyed H. Ghaffari, Davood Bashash
Expert Review of Anticancer Therapy.2024; 24(7): 493. CrossRef - Holistic View of ALK TKI Resistance in ALK-Positive Anaplastic Large Cell Lymphoma
Yuan Wang, Jing He, Manyu Xu, Qingfeng Xue, Cindy Zhu, Juan Liu, Yaping Zhang, Wenyu Shi
Frontiers in Oncology.2022;[Epub] CrossRef - Inhibiting ALK-TOPK signaling pathway promotes cell apoptosis of ALK-positive NSCLC
Juanjuan Xiao, Lu Zhang, Huijun Yi, Ling Zou, Jianmei Mo, Feng Xue, Jinhua Zheng, Yingze Huang, Hui Lu, Hansheng Wu, Peipei Xue, Xin Zhang, Lifei He, Zhaoxin Li, Shigui Pang, Guibin Qiao, Qiuhong Duan, Feng Zhu
Cell Death & Disease.2022;[Epub] CrossRef - CORR Insights®: Identification of a Novel MAN1A1-ROS1 Fusion Gene Through mRNA-based Screening for Tyrosine Kinase Gene Aberrations in a Patient with Leiomyosarcoma
Xiaodong Tang
Clinical Orthopaedics & Related Research.2021; 479(4): 853. CrossRef - Combined crizotinib and endocrine drugs inhibit proliferation, migration, and colony formation of breast cancer cells via downregulation of MET and estrogen receptor
Nehad M. Ayoub, Amer E. Alkhalifa, Dalia R. Ibrahim, Ahmed Alhusban
Medical Oncology.2021;[Epub] CrossRef - The Dual Role of Autophagy in Crizotinib-Treated ALK+ ALCL: From the Lymphoma Cells Drug Resistance to Their Demise
Estelle Espinos, Raymond Lai, Sylvie Giuriato
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Caiyu Lin, Hengyi Chen, Rui Han, Li Li, Conghua Lu, Shuai Hao, Yubo Wang, Yong He
Thoracic Cancer.2021; 12(23): 3184. CrossRef
- The PI3K signaling pathway; from normal lymphopoiesis to lymphoid malignancies
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- Experiences and Opinions Related to End-of-Life Discussion: From Oncologists' and Resident Physicians' Perspectives
- Su-Jin Koh, Shinmi Kim, JinShil Kim, Bhumsuk Keam, Dae Seog Heo, Kyung Hee Lee, Bong-Seog Kim, Jee Hyun Kim, Hye Jung Chang, Sun Kyung Baek
- Cancer Res Treat. 2018;50(2):614-623. Published online July 3, 2017
- DOI: https://doi.org/10.4143/crt.2016.446
-
Abstract
PDFPubReaderePub
- Purpose
The aims of this study were to explore how oncologists and resident physicians practice end-of-life (EOL) discussions and to solicit their opinions on EOL discussions as a means to improve the quality of EOL care.
Materials and Methods
A survey questionnaire was developed to explore the experiences and opinions about EOL discussions among oncologists and residents. Descriptive statistics, the t test, and the chisquare test were performed for the analyses.
Results
A total of 147 oncologists and 229 residents participated in this study. The study respondents reported diverse definitions of “terminal state,” and mostrespondents tried to disclose the patient’s condition to the patient and/or family members. Both groups were involved in EOL care discussions, with a rather low satisfaction level (57.82/100). The best timing to initiate discussionwas consideredwhen metastasis or disease recurrence occurred orwhen withdrawal of chemotherapy was anticipated. Furthermore, the study respondents suggested that patients and their family members should be included in the EOL discussion. Medical, legal, and ethical knowledge and communication difficulties along with practical issues were revealed as barriers and facilitators for EOL discussion.
Conclusion
This study explored various perspectives of oncologists and resident physicians for EOL discussion. Since the Life-Sustaining-Treatment Decision-Making Act will be implemented shortly in Korea, now is the time for oncologists and residents to prepare themselves by acquiring legal knowledge and communication skills. To achieve this, education, training, and clinical tools for healthcare professionals are required. -
Citations
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Shin Hye Yoo, Wonho Choi, Yejin Kim, Min Sun Kim, Hye Yoon Park, Bhumsuk Keam, Dae Seog Heo
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Hyeyeong Kim, Hyeon-Su Im, Kyong Og Lee, Young Joo Min, Jae-Cheol Jo, Yunsuk Choi, Yoo Jin Lee, Daseul Kang, Changyoung Kim, Su-Jin Koh, Jaekyung Cheon
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