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Volume 48(2); April 2016
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Review Article
Robotic Surgery for Rectal Cancer: An Update in 2015
Jung Myun Kwak, Seon Hahn Kim
Cancer Res Treat. 2016;48(2):427-435.   Published online February 3, 2016
DOI: https://doi.org/10.4143/crt.2015.478
AbstractAbstract PDFPubReaderePub
During the last decade, robotic surgery for rectal cancer has rapidly gained acceptance among colorectal surgeons worldwide, with well-established safety and feasibility. The lower conversion rate and better surgical specimen quality of robotic compared with laparoscopic surgery potentially improves survival. Earlier recovery of voiding and sexual function after robotic total mesorectal excision is another favorable outcome. Long-term survival data are sparse with no evidence that robotic surgery offers major benefits in oncological outcomes. Although initial reports are promising, more rigorous scientific evaluation in multicenter, randomized clinical trials should be performed to definitely determine the advantages of robotic rectal cancer surgery.

Citations

Citations to this article as recorded by  
  • Robotic versus laparoscopic surgery for colorectal disease: a systematic review, meta-analysis and meta-regression of randomised controlled trials
    A Thrikandiyur, G Kourounis, S Tingle, P Thambi
    The Annals of The Royal College of Surgeons of England.2024; 106(8): 658.     CrossRef
  • Updates in robotic colorectal surgery
    Mahmood Al-Dhaheri, Ibrahim Amer, Noof AL. Naimi, Amjad Parvaiz
    Surgery (Oxford).2023; 41(1): 41.     CrossRef
  • Short-term outcomes in robotic vs laparoscopic ileal pouch-anal anastomosis surgery: a propensity score match study
    Sofoklis Panteleimonitis, Mahmood Al-Dhaheri, Mick Harper, Ibrahim Amer, Ayman Abdelhafiz Ahmed, Mohamed Abu Nada, Amjad Parvaiz
    Langenbeck's Archives of Surgery.2023;[Epub]     CrossRef
  • Advances in Rectal Cancer Surgery
    Karyn B. Stitzenberg, Emilie Barnes
    Clinical Colorectal Cancer.2022; 21(1): 55.     CrossRef
  • Trends of robotic-assisted surgery for thyroid, colorectal, stomach and hepatopancreaticobiliary cancer: 10 year Korea trend investigation
    Liang An, Kyo Sun Hwang, Shin-Hoo Park, You Na Kim, Se-Jin Baek, Sungsoo Park, Woo Jin Hyung, Woung Youn Chung, Seon-Hahn Kim
    Asian Journal of Surgery.2021; 44(1): 199.     CrossRef
  • Surgical Complexity and Outcome During the Implementation Phase of a Robotic Colorectal Surgery Program—A Retrospective Cohort Study
    Catharina Müller, Johannes Laengle, Stefan Riss, Michael Bergmann, Thomas Bachleitner-Hofmann
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Oncological outcomes of robotic-assisted total mesorectal excision after neoadjuvant concurrent chemoradiotherapy in patients with rectal cancer
    Po-Jung Chen, Wei-Chih Su, Tsung-Kun Chang, Yen-Cheng Chen, Ching-Chun Li, Tzu-Chieh Yin, Hsiang-Lin Tsai, Cheng-Jen Ma, Ching-Wen Huang, Jaw-Yuan Wang
    Asian Journal of Surgery.2021; 44(7): 957.     CrossRef
  • Robotic Surgery in Rectal Cancer
    Sara Margarida Leonardo de Oliveira, Laura Elisabete Ribeiro Barbosa
    Journal of Coloproctology.2021; 41(02): 198.     CrossRef
  • Feasibility of robot-assisted surgery in elderly patients with rectal cancer
    Wei-Chih Su, Ching-Wen Huang, Cheng-Jen Ma, Po-Jung Chen, Hsiang-Lin Tsai, Tsung-Kun Chang, Yen-Cheng Chen, Ching-Chun Li, Yung-Sung Yeh, Jaw-Yuan Wang
    Journal of Minimal Access Surgery.2021; 17(2): 165.     CrossRef
  • A comparison of open, laparoscopic and robotic total mesorectal excision: trial sequential analysis and network meta‐analysis
    B. Zheng, X. Zhang, X. Wang, L. Ge, M. Wei, L. Bi, X. Deng, Q. Wang, J. Li, Z. Wang
    Colorectal Disease.2020; 22(4): 382.     CrossRef
  • Updates in robotic colorectal surgery
    Muhammad F. Shah, Irfan I. Nasir, Amjad Parvaiz
    Surgery (Oxford).2020; 38(1): 38.     CrossRef
  • Robotic sphincter saving rectal cancer surgery: A learning curve analysis
    Afag Aghayeva, Bilgi Baca
    The International Journal of Medical Robotics and Computer Assisted Surgery.2020;[Epub]     CrossRef
  • Oncological Outcomes of Robotic-Assisted Surgery With High Dissection and Selective Ligation Technique for Sigmoid Colon and Rectal Cancer
    Tzu-Chieh Yin, Wei-Chih Su, Po-Jung Chen, Tsung-Kun Chang, Yen-Cheng Chen, Ching-Chun Li, Yi-Chien Hsieh, Hsiang-Lin Tsai, Ching-Wen Huang, Jaw-Yuan Wang
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Robotic Surgery for Colorectal Cancer
    Muhammad Fahd Shah, Irfan ul Islam  Nasir, Amjad Parvaiz
    Visceral Medicine.2019; 35(4): 247.     CrossRef
  • Robotic Versus Laparoscopic Stapler Use for Rectal Transection in Robotic Surgery for Cancer
    Deniz Atasoy, Erman Aytac, Volkan Ozben, Onur Bayraktar, Ilknur Erenler Bayraktar, Afag Aghayeva, Bilgi Baca, Ismail Hamzaoglu, Tayfun Karahasanoglu
    Journal of Laparoendoscopic & Advanced Surgical Techniques.2018; 28(5): 501.     CrossRef
  • Robotic rectal cancer surgery in obese patients may lead to better short-term outcomes when compared to laparoscopy: a comparative propensity scored match study
    Sofoklis Panteleimonitis, Oliver Pickering, Hassan Abbas, Mick Harper, Ngianga Kandala, Nuno Figueiredo, Tahseen Qureshi, Amjad Parvaiz
    International Journal of Colorectal Disease.2018; 33(8): 1079.     CrossRef
  • Implementation of robotic rectal surgery training programme: importance of standardisation and structured training
    Sofoklis Panteleimonitis, Sotirios Popeskou, Mohamed Aradaib, Mick Harper, Jamil Ahmed, Mukhtar Ahmad, Tahseen Qureshi, Nuno Figueiredo, Amjad Parvaiz
    Langenbeck's Archives of Surgery.2018; 403(6): 749.     CrossRef
  • Robotic rectal surgery has advantages over laparoscopic surgery in selected patients and centres
    J. S. Khan, A. K. Banerjee, S.‐H. Kim, T. A. Rockall, D. G. Jayne
    Colorectal Disease.2018; 20(10): 845.     CrossRef
  • Robotic colorectal surgery
    Sofoklis Panteleimonitis, Amjad Parvaiz
    Surgery (Oxford).2017; 35(3): 151.     CrossRef
  • Hybrid transanal and laparoscopic hand‐assisted total mesorectal excision for low rectal cancer
    Narimantas E. Samalavicius, Dulskas Audrius, Aliukonis Vygintas, Rackauskas Rokas, Kilius Alfredas
    ANZ Journal of Surgery.2017; 87(11): 953.     CrossRef
  • Robotic-assisted total mesorectal excision with the single-docking technique for patients with rectal cancer
    Ching-Wen Huang, Hsiang-Lin Tsai, Yung-Sung Yeh, Wei-Chih Su, Ming-Yii Huang, Chun-Ming Huang, Yu-Tang Chang, Jaw-Yuan Wang
    BMC Surgery.2017;[Epub]     CrossRef
  • Learning Curves in Robotic Rectal Cancer Surgery: A literature Review
    Moneeb Nasir, Sofoklis Panteleimonitis, Jamil Ahmed, Hassan Abbas, Amjad Parvaiz
    Journal of Minimally Invasive Surgical Sciences.2016;[Epub]     CrossRef
  • Learning Curves in Robotic Rectal Cancer Surgery: A literature Review
    Moneeb Nasir, Sofoklis Panteleimonitis, Jamil Ahmed, Hassan Abbas, Amjad Parvaiz
    Journal of Minimally Invasive Surgical Sciences.2016;[Epub]     CrossRef
  • Robotics in Colorectal Surgery
    Allison Weaver, Scott Steele
    F1000Research.2016; 5: 2373.     CrossRef
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Special Articles
Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2013
Chang-Mo Oh, Young-Joo Won, Kyu-Won Jung, Hyun-Joo Kong, Hyunsoon Cho, Jong-Keun Lee, Duk Hyoung Lee, Kang Hyun Lee, The Community of Population-Based Regional Cancer Registries
Cancer Res Treat. 2016;48(2):436-450.   Published online March 3, 2016
DOI: https://doi.org/10.4143/crt.2016.089
AbstractAbstract PDFPubReaderePub
Purpose
This study described the 2013 nationwide cancer statistics in Korea, including cancer incidence, survival, prevalence, and mortality.
Materials and Methods
Cancer incidence data from 1999-2013 were obtained from Korea National Cancer Incidence Database and followed until December 31, 2014. Mortality data from 1983-2013 were obtained from Statistics Korea. The prevalence was defined as the number of cancer patients alive on January 1, 2014 among all cancer patients diagnosed since 1999. Crude, and age-standardized and 5-year relative survival rates were also calculated.
Results
In 2013, a total of 225,343 and 75,334 Koreans were newly diagnosed and died from cancer, respectively. The age-standardized rates for cancer incidence and mortality in 2013 were 290.5 and 87.9 per 100,000, respectively. The age-standardized cancer incidence rate increased 3.1% annually between 1999 and 2013. However, the overall cancer incidence rates have decreased slightly in recent years (2011 to 2013). The age-standardized rate for all-cancer mortality has decreased 2.7% annually since 2002. Overall, the 5-year relative survival rate for people diagnosed with cancer between 2009 and 2013 was 69.4%, which represents an improved survival rate as compared with 41.2% for people diagnosed between 1993 and 1995.
Conclusion
Age-standardized cancer incidence rates have decreased between 2011 and 2013; mortality rates have also declined since 2002, while 5-year survival rates have improved remarkably from 1993-1995 to 2009-2013 in Korea.

Citations

Citations to this article as recorded by  
  • Impact of high body mass index on hepatocellular carcinoma risk in chronic liver disease: A population-based prospective cohort study
    Moonho Kim, Baek Gyu Jun, Hwang Sik Shin, Jee-Jeon Yi, Sang Gyune Kim, Sang-Wook Yi, Sona Frankova
    PLOS ONE.2025; 20(1): e0316175.     CrossRef
  • Randomized controlled trial comparing the costs of gastric cancer screening systems between serological risk-based upper gastrointestinal endoscopy and the existing barium photofluorography: gastric cancer screening labeled by serum examination in place o
    Takuji Gotoda, Hideki Ishikawa, Chika Kusano, Sho Suzuki, Hirohide Ohnishi, Kentaro Sugano, Yutaka Matsuyama
    Gastric Cancer.2024; 27(1): 36.     CrossRef
  • An Investigation into Cell-Free DNA in Different Common Cancers
    Samira Nafar, Kamran Hosseini, Negin Shokrgozar, Amir Yousef Farahmandi, Vahab Alamdari-Palangi, Ali Saber Sichani, Jafar Fallahi
    Molecular Biotechnology.2024; 66(12): 3462.     CrossRef
  • Cancer screening programs in South-east Asia and Western Pacific
    Hwee-Lin Wee, Karen Canfell, Han-Mo Chiu, Kui Son Choi, Brian Cox, Nirmala Bhoo-Pathy, Kate T Simms, Chisato Hamashima, Qianyu Shen, Brandon Chua, Niyomsri Siwaporn, Esther Toes-Zoutendijk
    BMC Health Services Research.2024;[Epub]     CrossRef
  • Incidence and survival rates of primary cutaneous malignancies in Korea, 1999–2019: A nationwide population‐based study
    Soon‐Hyo Kwon, Sangmin Choi, Joung Soo Kim, Sang Seok Kim, Mihn‐Sook Jue, Soo Hong Seo, Jihye Park, Mi Ryung Roh, Je‐Ho Mun, Jun Young Kim, Jee Woong Choi, Ji Won Byun, Sanghyun Park, Min Sung Kim, Seok‐Jong Lee
    The Journal of Dermatology.2024; 51(4): 532.     CrossRef
  • Geraniol and citral: recent developments in their anticancer credentials opening new vistas in complementary cancer therapy
    Gauri Srivastava, Esha Mukherjee, Ruchika Mittal, Deepak Ganjewala
    Zeitschrift für Naturforschung C.2024; 79(7-8): 163.     CrossRef
  • Gastric cancer detection rates using GI endoscopy with serologic risk stratification: a randomized controlled trial
    Chika Kusano, Takuji Gotoda, Hideki Ishikawa, Sho Suzuki, Hisatomo Ikehara, Yutaka Matsuyama
    Gastrointestinal Endoscopy.2024; 100(1): 55.     CrossRef
  • Assessment of malignant potential for HPV types 16, 52, and 58 in the uterine cervix within a Korean cohort
    Juhun Lee, Dong Ja Kim, Hyun Jung Lee
    Scientific Reports.2024;[Epub]     CrossRef
  • Predicted Cervical Cancer Prevention: Impact of National HPV Vaccination Program on Young Women in South Korea
    Kyeongmin Kwak, Seung-sik Hwang
    Cancer Research and Treatment.2024; 56(3): 898.     CrossRef
  • Living lab modelling as a pilot study assessing the potential psychological health benefits of forest environment for cancer survivors
    Mi-Kyung Kim, Hyo Jin Park, Kyung Ju Lee
    Obstetrics & Gynecology Science.2024; 67(4): 404.     CrossRef
  • Surgical and Survival Outcomes of Operable Gastric Cancer—Experience from a Tertiary Care Center in South India
    D. Suresh Kumar, S. Navin Noushad, M. P. Viswanathan, Vishnu Deepthi S.
    Indian Journal of Surgical Oncology.2023; 14(1): 48.     CrossRef
  • Overview of Chemotherapy for Gastric Cancer
    Yasushi Sato, Koichi Okamoto, Yoshifumi Kida, Yasuhiro Mitsui, Yutaka Kawano, Masahiro Sogabe, Hiroshi Miyamoto, Tetsuji Takayama
    Journal of Clinical Medicine.2023; 12(4): 1336.     CrossRef
  • Underuse of Gastric Cancer Screening Services among Koreans with Type 2 Diabetes
    Kumban Walter Chuck, Seri Hong, Yunhwan Lee
    Healthcare.2023; 11(7): 927.     CrossRef
  • Linking dysbiosis to precancerous stomach through inflammation: Deeper than and beyond imaging
    Catarina Lopes, Tatiana C. Almeida, Pedro Pimentel-Nunes, Mário Dinis-Ribeiro, Carina Pereira
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Survival rate of thyroid cancer in the Asian countries: a systematic review and meta-analysis study
    Soheil Hassanipour, Reza Zare, Alireza Shahedi, Hamed Delam
    Endocrine.2023; 82(2): 237.     CrossRef
  • Do Concurrent Multiple Infections with High-Risk HPVs Carry a More Malignant Potential than a Single Infection in the Uterine Cervix?
    Juhun Lee, Hyun Jung Lee
    Journal of Clinical Medicine.2023; 12(19): 6155.     CrossRef
  • Comparative Analysis of Driver Mutations and Transcriptomes in Papillary Thyroid Cancer by Region of Residence in South Korea
    Jandee Lee, Seonhyang Jeong, Hwa Young Lee, Sunmi Park, Meesson Jeong, Young Suk Jo
    Endocrinology and Metabolism.2023; 38(6): 720.     CrossRef
  • Mobile web‐based self‐management program for breast cancer patients with chemotherapy‐induced amenorrhoea: A quasi‐experimental study
    Jin‐Hee Park, Yong Sik Jung, Ji Young Kim, Sun Hyoung Bae
    Nursing Open.2022; 9(1): 655.     CrossRef
  • Structural and functional brain alterations associated with cancer‐associated cognitive decline in gastric cancer patients: A preliminary longitudinal neuroimaging study
    Jaeun Ahn, DeokJong Lee, Young‐Chul Jung, Kyung Ran Kim
    Brain and Behavior.2022;[Epub]     CrossRef
  • Trends in the incidence of thyroid cancer in Incheon Province, South Korea, from 2004 to 2013: A representative sample study from Incheon cancer registry
    Jeongshim Lee, Hyun Young Lee, Woo Chul Kim
    Asia-Pacific Journal of Clinical Oncology.2022;[Epub]     CrossRef
  • Impact of overweight and obesity on the risk of hepatocellular carcinoma: a prospective cohort study in 14.3 million Koreans
    Baek Gyu Jun, Moonho Kim, Hwang Sik Shin, Jee-Jeon Yi, Sang-Wook Yi
    British Journal of Cancer.2022; 127(1): 109.     CrossRef
  • Comparison of Risk Factors for Cholangiocarcinoma and Hepatocellular Carcinoma: A Prospective Cohort Study in Korean Adults
    In Rae Cho, Sang-Wook Yi, Ja Sung Choi, Jee-Jeon Yi
    Cancers.2022; 14(7): 1709.     CrossRef
  • An empirical review on the risk factors, therapeutic strategies and materials at nanoscale for the treatment of oral malignancies
    Parveez Ahamed Abdul Azees, Suganthy Natarajan, Bennett T. Amaechi, Nooruddin Thajuddin, Vinay B. Raghavendra, Kathirvel Brindhadevi, Arivalagan Pugazhendhi, Tran Nhat Phuong
    Process Biochemistry.2022; 118: 283.     CrossRef
  • Health Care Utilization and Anti-Cancer Drug Expenditure for Six Solid Cancers in Korea From 2007 to 2019
    Juhee Park, Kyeongjun Moon, Dong-Sook Kim
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Clinical assessment of T2 papillary thyroid carcinoma: a retrospective study conducted at a single tertiary institution
    Hyesung Kim, Kwangsoon Kim, Ja Seong Bae, Jeong Soo Kim
    Scientific Reports.2022;[Epub]     CrossRef
  • Incidence of Cancer and Asbestos-Related Diseases among Residents Living near Abandoned Asbestos Mines in South Korea: A Retrospective Cohort Study Using National Health Insurance Database
    Kyeongmin Kwak, Kyung Ehi Zoh, Domyung Paek
    International Journal of Environmental Research and Public Health.2021; 18(3): 875.     CrossRef
  • Impact of prior cancer history on survival of patients with gastric cancer
    Li Wen, Kun Yu, Hongjiang Lu, Guansheng Zhong
    European Journal of Surgical Oncology.2021; 47(9): 2286.     CrossRef
  • Effect of prior cancer on survival outcomes for patients with advanced prostate cancer
    Yechen Wu, Xi Chen, Duocheng Qian, Wei Wang, Yiping Zhang, Jinxin Hu, Jun Zhu, Qiang Wu, Tinghu Cao
    BMC Urology.2021;[Epub]     CrossRef
  • Apoptotic Effects of Anthocyanins from Vitis coignetiae Pulliat Are Enhanced by Augmented Enhancer of the Rudimentary Homolog (ERH) in Human Gastric Carcinoma MKN28 Cells
    Cheol Park, Won Sup Lee, Se-Il Go, Sang-Ho Jeong, Jiyun Yoo, Hee-Jae Cha, Young-Joon Lee, Heui-Soo Kim, Sun-Hee Leem, Hye Jung Kim, Gon Sup Kim, Soon-Chan Hong, Yung Hyun Choi
    International Journal of Molecular Sciences.2021; 22(6): 3030.     CrossRef
  • Prior to Breast MRI Guidelines in Korea, Where Were We?
    Cheong Hoon Hwang, Miribi Rho, Minah Lee, Ga Ram Kim, Vivian Youngjean Park, Jung Hyun Yoon, Min Jung Kim
    Investigative Magnetic Resonance Imaging.2021; 25(1): 35.     CrossRef
  • An Adaptive Machine Learning System for predicting recurrence of child maltreatment: A routine activity theory perspective
    Yuzhang Han, Minoo Modaresnezhad, Hamid Nemati
    Knowledge-Based Systems.2021; 227: 107164.     CrossRef
  • Transpyloric optic navigation of tumor using a laparoscope during totally laparoscopic distal gastrectomy for gastric cancer
    Sola Lee, Ho Goon Kim, Dong Yeon Kang, Dong Yi Kim, Seong Yeob Ryu
    Journal of Minimally Invasive Surgery.2021; 24(2): 76.     CrossRef
  • Recurrence of Cancer-associated Venous Thromboembolism between 2009 and 2013: A Nationwide Korean Study
    Hun-Gyu Hwang, Ju Hyun Lee, Junshik Hong, Sang-A Kim, Yang-Ki Kim, Myung Shin Kim, Soo-Mee Bang
    Clinical & Experimental Thrombosis and Hemostasis.2021; 7(1): 14.     CrossRef
  • Value of computed tomography-defined visceral fat area as a risk factor for endometrial cancer
    Jae-hyun Cho, Jeong Sig Kim, Suyeon Park, Woo Young Kim
    Clinical and Experimental Obstetrics & Gynecology.2021;[Epub]     CrossRef
  • Inflammatory markers as prognostic indicators in pancreatic cancer patients who underwent gemcitabine-based palliative chemotherapy
    Hong Jun Kim, Suk-young Lee, Dae Sik Kim, Eun Joo Kang, Jung Sun Kim, Yoon Ji Choi, Sang Cheul Oh, Jae Hong Seo, Jun Suk Kim
    The Korean Journal of Internal Medicine.2020; 35(1): 171.     CrossRef
  • Effects of a web-based expert support self-management program (WEST) for women with breast cancer: A randomized controlled trial
    Hye-Jin Kim, Hee-Seung Kim
    Journal of Telemedicine and Telecare.2020; 26(7-8): 433.     CrossRef
  • Survival Rate of Prostate Cancer in Asian Countries: A Systematic Review and Meta-Analysis
    Soheil Hassanipour, Hamed Delam, Morteza Arab-Zozani, Elham Abdzadeh, Seyyed Ali Hosseini, Hossein-Ali Nikbakht, Mahdi Malakoutikhah, Mohammad Taghi Ashoobi, Mohammad Fathalipour, Hamid Salehiniya, Shirin Riahi
    Annals of Global Health.2020; 86(1): 2.     CrossRef
  • Trends in Influenza Vaccination Coverage Rates among Korean Cancer Survivors: Analysis of the Korea National Health and Nutrition Examination Survey III–VI
    Ye-Seul Kim, Jae-woo Lee, Hee-Taik Kang, Yonghwan Kim, Hyo-Sun You
    Korean Journal of Family Medicine.2020; 41(1): 45.     CrossRef
  • Metabolic comorbidities and medical institution utilization among breast cancer survivors: a national population-based study
    Jaesung Heo, Mison Chun, Young-Taek Oh, O Kyu Noh, Logyoung Kim
    The Korean Journal of Internal Medicine.2020; 35(2): 421.     CrossRef
  • Suicide risk after cancer diagnosis among older adults: A nationwide retrospective cohort study
    Jae Woo Choi, Eun-Cheol Park
    Journal of Geriatric Oncology.2020; 11(5): 814.     CrossRef
  • The global, regional, and national burden of stomach cancer in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease study 2017
    Arash Etemadi, Saeid Safiri, Sadaf G Sepanlou, Kevin Ikuta, Catherine Bisignano, Ramin Shakeri, Mohammad Amani, Christina Fitzmaurice, Molly Nixon, Nooshin Abbasi, Hassan Abolhassani, Shailesh M Advani, Mohsen Afarideh, Tomi Akinyemiju, Tahiya Alam, Mahta
    The Lancet Gastroenterology & Hepatology.2020; 5(1): 42.     CrossRef
  • Characterization of Metabolic Syndrome Risk Factors and Health-Related Behaviors in Korean Patients With Breast Cancer by Abdominal Obesity Status
    Hye-Jin KIM, Hee-Seung KIM, Hye-Ryoung KIM, Yang-Sook YOO, Byung Joo SONG
    Journal of Nursing Research.2020; 28(2): e74.     CrossRef
  • Citral Induced Apoptosis through Modulation of Key Genes Involved in Fatty Acid Biosynthesis in Human Prostate Cancer Cells: In Silico and In Vitro Study
    Sri Renukadevi Balusamy, Haribalan Perumalsamy, Karpagam Veerappan, Md. Amdadul Huq, S. Rajeshkumar, T. Lakshmi, Yeon Ju Kim, Paul W. Doetsch
    BioMed Research International.2020;[Epub]     CrossRef
  • Thyroid isthmus agenesis and its clinical significance in a large-scale multidetector CT-based study
    Seung Kwan Kim, Hyung Suk Seo, Young Hen Lee, Gil Soo Son, Sang-il Suh
    Clinical Imaging.2020; 66: 106.     CrossRef
  • Age-Specific Breast Density Changes in Taiwanese Women: A Cross-Sectional Study
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  • Association between the National Cancer Screening Programme (NSCP) for gastric cancer and oesophageal cancer mortality
    Jie-Hyun Kim, Kyung-Do Han, Jung Kuk Lee, Hyun-Soo Kim, Jae Myung Cha, Sohee Park, Joo Sung Kim, Won Ho Kim
    British Journal of Cancer.2020; 123(3): 480.     CrossRef
  • Comparison of long-term prognosis for differentiated thyroid cancer according to the 7th and 8th editions of the AJCC/UICC TNM staging system
    Kwangsoon Kim, Jin Kyong Kim, Cho Rok Lee, Sang-Wook Kang, Jandee Lee, Jong Ju Jeong, Kee-Hyun Nam, Woong Youn Chung
    Therapeutic Advances in Endocrinology and Metabolism.2020;[Epub]     CrossRef
  • Clinical Assessment of Pediatric Patients with Differentiated Thyroid Carcinoma: A 30‐Year Experience at a Single Institution
    Kwangsoon Kim, Cho Rok Lee, Sang‐Wook Kang, Jandee Lee, Jong Ju Jeong, Kee‐Hyun Nam, Woong Youn Chung
    World Journal of Surgery.2020; 44(10): 3383.     CrossRef
  • The Combined Impact of Chronic Kidney Disease and Diabetes on the Risk of Colorectal Cancer Depends on Sex: A Nationwide Population-Based Study
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    Yonsei Medical Journal.2020; 61(6): 506.     CrossRef
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    Ophthalmic Epidemiology.2020; 27(6): 438.     CrossRef
  • The Clinical Impact of Body Mass Index on Breast Cancer in Korea: A Nationwide Population-Based Cohort Study
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    Journal of Breast Disease.2020; 8(1): 51.     CrossRef
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    Clinical and Translational Gastroenterology.2020; 11(9): e00221.     CrossRef
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    Journal of Cancer Education.2019; 34(5): 950.     CrossRef
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    Ryan Morgan, Michael Cassidy, Susanna W.L. DeGeus, Jennifer Tseng, David McAneny, Teviah Sachs
    Journal of Gastrointestinal Surgery.2019; 23(2): 239.     CrossRef
  • Regional Differences in Colorectal Cancer Mortality Between 2000 and 2013 in Republic of Korea
    Hyeong Taek Woo, Jin Ah Sim, Jonghoon Mo, Young Ho Yun, Aesun Shin
    Journal of Epidemiology.2019; 29(10): 399.     CrossRef
  • Effect of gastrectomy on blood pressure in early gastric cancer survivors with hypertension
    Hak Jin Kim, Eun Jeong Cho, Mi Hyang Kwak, Bang Wool Eom, Hong Man Yoon, Soo-Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Keun Won Ryu, Young-Woo Kim, Il Ju Choi
    Supportive Care in Cancer.2019; 27(6): 2237.     CrossRef
  • Increased prevalence of metabolic syndrome in adult cancer survivors: Asian first report in community setting
    Minkyung Kim, In-Hoo Kim, Min Kyung Lim, Yeol Kim, Boyoung Park
    Cancer Epidemiology.2019; 58: 130.     CrossRef
  • Prediagnosis obesity and secondary primary cancer risk in female cancer survivors: A national cohort study
    So‐Youn Jung, Young Ae Kim, Minkyung Jo, Sang Min Park, Young‐Joo Won, Haryeom Ghang, Sun‐Young Kong, Kyu‐Won Jung, Eun Sook Lee
    Cancer Medicine.2019; 8(2): 824.     CrossRef
  • Association between De Ritis ratio (aspartate aminotransferase/alanine aminotransferase) and oncological outcomes in bladder cancer patients after radical cystectomy
    Yun-Sok Ha, Sang Won Kim, So Young Chun, Jae-Wook Chung, Seock Hwan Choi, Jun Nyung Lee, Bum Soo Kim, Hyun Tae Kim, Eun Sang Yoo, Tae Gyun Kwon, Won Tae Kim, Wun-Jae Kim, Tae-Hwan Kim
    BMC Urology.2019;[Epub]     CrossRef
  • Human papillomavirus genotype-specific risk in cervical carcinogenesis
    Kyeong A So, In Ho Lee, Ki Heon Lee, Sung Ran Hong, Young Jun Kim, Hyun Hee Seo, Tae Jin Kim
    Journal of Gynecologic Oncology.2019;[Epub]     CrossRef
  • Cost for treatment and follow‐up of thyroid cancer increases according to the severity of disease
    Soo Young Kim, Seok‐Mo Kim, Hojin Chang, Bup‐Woo Kim, Yong Sang Lee, Soon‐Sun Kwon, Hyunjung Shin, Hang‐Seok Chang, Cheong Soo Park
    Head & Neck.2019; 41(7): 2376.     CrossRef
  • Methylmalonic Acid and Homocysteine as Indicators of Vitamin B12 Deficiency in Patients with Gastric Cancer after Gastrectomy
    Sae-Mi Lee, Jongwon Oh, Mi-Ryung Chun, Soo-Youn Lee
    Nutrients.2019; 11(2): 450.     CrossRef
  • Case Studies of a Structured Singing Experience for the Psychological Well-Being of Hospice Patients
    Ji Eun Oh, Hyun Ju Chong, Aimee Jeehae Kim
    Alternative and Complementary Therapies.2019; 25(2): 85.     CrossRef
  • Routine low-dose calcium supplementation after thyroidectomy does not reduce the rate of symptomatic hypocalcemia: a prospective randomized trial
    Jun Woo Lee, Jong-Kyu Kim, Hyungju Kwon, Woosung Lim, Byung-In Moon, Nam Sun Paik
    Annals of Surgical Treatment and Research.2019; 96(4): 177.     CrossRef
  • Association between sedative-hypnotic medication use and incidence of cancer in Korean Nation Health Insurance Service data
    Sun Jae Jung, Joonki Lee, Jae-Won Choi, Soohyun Kim, Aesun Shin, Yu Jin Lee
    Sleep Medicine.2019; 60: 159.     CrossRef
  • Estrogenic Activity of Sanguiin H-6 through Activation of Estrogen Receptor α Coactivator-binding Site
    Tuy An Trinh, Eun-Ji Park, Dahae Lee, Ji Hoon Song, Hye Lim Lee, Ki Hyun Kim, Younghoon Kim, Kiwon Jung, Ki Sung Kang, Jeong-Eun Yoo
    Natural Product Sciences.2019; 25(1): 28.     CrossRef
  • Childbirth in young Korean women with previously treated breast cancer: The SMARTSHIP study
    Hak Min Lee, Bo Wook Kim, Seho Park, Sungmin Park, Jeon Eon Lee, Young Jin Choi, Sung Yong Kim, Sang Uk Woo, Hyun Jo Youn, Ilkyun Lee
    Breast Cancer Research and Treatment.2019; 176(2): 419.     CrossRef
  • Age-standardized expected years of life lost: quantification of cancer severity
    Yueh Wang, Chun-Ju Chiang, Wen-Chung Lee
    BMC Public Health.2019;[Epub]     CrossRef
  • Using recursive partitioning approach to select tumor‐associated antigens in immunodiagnosis of gastric adenocarcinoma
    Jiejie Qin, Shuaibing Wang, Jianxiang Shi, Yan Ma, Keyan Wang, Hua Ye, Xiaojun Zhang, Peng Wang, Xiao Wang, Chunhua Song, Liping Dai, Kaijuan Wang, Binghua Jiang, Jianying Zhang
    Cancer Science.2019; 110(6): 1829.     CrossRef
  • The predictive factors of gastric cancer recurrence after the completion of adjuvant chemotherapy in advanced gastric cancer
    Yeon-Ji Kim, Woo Chul Chung, Gun Jung Youn, Kyong-Hwa Jun, Hyung-Min Chin
    Revista Española de Enfermedades Digestivas.2019;[Epub]     CrossRef
  • Red meat intake, CYP2E1 and PPARγ polymorphisms, and colorectal cancer risk
    Na-Hui Kim, Ju Eun Seol, Jeongseon Kim, Bong-Hwa Lee, Dae-Yong Hwang, Jinyoung Jeong, Hun-Jae Lee, Yoon-Ok Ahn, Dong-Hyun Kim, Jung Eun Lee
    European Journal of Cancer Prevention.2019; 28(4): 304.     CrossRef
  • National practice patterns and direct medical costs for prostate cancer in Korea across a 10 year period: a nationwide population-based study using a national health insurance database
    Ho Won Kang, Seok-Joong Yun, Jae Il Chung, Hoon Choi, Jae Heon Kim, Ho Song Yu, Yun-Sok Ha, In-Chang Cho, Hyung Joon Kim, Hyun Chul Chung, Jun Sung Koh, Wun-Jae Kim, Jong-Hyock Park, Ji Youl Lee, So-Young Kim
    BMC Health Services Research.2019;[Epub]     CrossRef
  • The Anti-Proliferation and Oxidative Damage-Related Mechanism of L-Carnitine in Human Colorectal Cancer Cells
    Jooyeon Lee, Jeong-Ran Park, Aera Jang, Se-Ran Yang
    Journal of Food Hygiene and Safety.2019; 34(3): 303.     CrossRef
  • Contrasting Epidemiology and Clinicopathology of Female Breast Cancer in Asians vs the US Population
    Ching-Hung Lin, Yoon Sim Yap, Kyung-Hun Lee, Seock-Ah Im, Yoichi Naito, Winnie Yeo, Takayuki Ueno, Ava Kwong, Huiping Li, Shu-Min Huang, Roland Leung, Wonshik Han, Benita Tan, Fu-Chang Hu, Chiun-Sheng Huang, Ann-Lii Cheng, Yen-Shen Lu
    JNCI: Journal of the National Cancer Institute.2019; 111(12): 1298.     CrossRef
  • Clinical Value of Lymph Node Ratio Integration with the 8th Edition of the UICC TNM Classification and 2015 ATA Risk Stratification Systems for Recurrence Prediction in Papillary Thyroid Cancer
    Jandee Lee, Seul Gi Lee, Kwangsoon Kim, Seung Hyuk Yim, Haengrang Ryu, Cho Rok Lee, Sang Wook Kang, Jong Ju Jeong, Kee-Hyun Nam, Woong Youn Chung, Young Suk Jo
    Scientific Reports.2019;[Epub]     CrossRef
  • Comprehensive immune profiling and immune-monitoring using body fluid of patients with metastatic gastric cancer
    Hyung Soon Park, Woo Sun Kwon, Sejung Park, Eunji Jo, So Jung Lim, Choong-kun Lee, Jii Bum Lee, Minkyu Jung, Hyo Song Kim, Seung-Hoon Beom, Jun Yong Park, Tae Soo Kim, Hyun Cheol Chung, Sun Young Rha
    Journal for ImmunoTherapy of Cancer.2019;[Epub]     CrossRef
  • A simple screening score to predict diabetes in cancer patients
    Ji-Su Kim, Sun-Hye Ko, Myong Ki Baeg, Kyung-Do Han
    Medicine.2019; 98(51): e18354.     CrossRef
  • Contemporary Debates in Adult Papillary Thyroid Cancer Management
    Donald S A McLeod, Ling Zhang, Cosimo Durante, David S Cooper
    Endocrine Reviews.2019; 40(6): 1481.     CrossRef
  • Usefulness Analysis of Urine Samples for Early Screening of Human Papilloma Virus Infection
    Yoon Sung Choi, Hyunwoo Jin, Kyung Eun Lee
    Journal of Cancer Prevention.2019; 24(4): 240.     CrossRef
  • The Role of Hospital Transfer in Reexamination Computed Tomography Scans: A Nationwide Cohort Study of Gastric Cancer Patients Undergoing Surgery
    Jaeyong Shin, Yoon Jung Choi, Young Choi, Sang Gyu Lee, Ji Man Kim
    Healthcare.2019; 8(1): 2.     CrossRef
  • Comprehensive Cancer Panel Sequencing Defines Genetic Diversity and Changes in the Mutational Characteristics of Pancreatic Cancer Patients Receiving Neoadjuvant Treatment
    Kyong-Ah Yoon, Sang Myung Woo, Yun-Hee Kim, Sun-Young Kong, Min Kyoung Lee, Sung-Sik Han, Tae Hyun Kim, Woo Jin Lee, Sang-Jae Park
    Gut and Liver.2019; 13(6): 683.     CrossRef
  • The Use of CD44 Variant 9 and Ki-67 Combination Can Predicts Prognosis Better Than Their Single Use in Early Gastric Cancer
    Se-Il Go, Gyung Hyuck Ko, Won Sup Lee, Jeong-Hee Lee, Sang-Ho Jeong, Young-Joon Lee, Soon Chan Hong, Woo Song Ha
    Cancer Research and Treatment.2019; 51(4): 1411.     CrossRef
  • Iodine promotes thyroid cancer development via SPANXA1 through the PI3K/AKT signalling pathway
    Xiaoyao Yang, Jingxue Sun, Jun Han, Lulu Sun, Hongzhi Wang, Dexin Zhang, Qingxiao Fang, Jiapeng Liu, Hong Qiao
    Oncology Letters.2019;[Epub]     CrossRef
  • Correlation analysis between ultrasonography and mammography with other risk factors related to breast cancer
    Wenxiao ZhangCui Xu, Cui Xu, Rui Li, Guanghe Cui, Minmin Wang, Min Wang
    Oncology Letters.2019;[Epub]     CrossRef
  • Stilbenes contribute to the anticancer effects of Rheum�undulatum L. through activation of apoptosis
    Tuy Trinh, Dahae Lee, Seonju Park, Seung Kim, Jae Park, Ji Kim, Ki Kang
    Oncology Letters.2019;[Epub]     CrossRef
  • Social Media Use for Cancer Education at a Community-Based Cancer Center in South Korea
    Jaesung Heo, Mison Chun, Hyun Woo Lee, Jeong-Hee Woo
    Journal of Cancer Education.2018; 33(4): 769.     CrossRef
  • TERT Promoter Mutation and Telomere Length in Salivary Gland Tumors
    Heejin Kim, Dongbin Ahn, Jin Ho Sohn, Yong-Hee Kim, Jae-Ho Lee, Hyunsu Lee
    Pathology & Oncology Research.2018; 24(3): 697.     CrossRef
  • Re-stratification of Patients with High-Risk Prostate Cancer According to the NCCN Guidelines among Patients Who Underwent Radical Prostatectomy: An Analysis Based on the K-CaP Registry
    Kwang Suk Lee, Kyo Chul Koo, In Young Choi, Ji Youl Lee, Jun Hyuk Hong, Choung-Soo Kim, Hyun Moo Lee, Sung Kyu Hong, Seok-Soo Byun, Koon Ho Rha, Byung Ha Chung
    Cancer Research and Treatment.2018; 50(1): 88.     CrossRef
  • Association between adult height, myocardial infarction, heart failure, stroke and death: a Korean nationwide population-based study
    Chan Soon Park, Eue-Keun Choi, Kyung-Do Han, Hyun Jung Lee, Tae-Min Rhee, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Si-Hyuck Kang, Seil Oh
    International Journal of Epidemiology.2018; 47(1): 289.     CrossRef
  • Right-Side Approach-Duet Totally Laparoscopic Distal Gastrectomy (R-Duet TLDG) Using a Three-Port to Treat Gastric Cancer
    Ho Seok Seo, Kyo Young Song, Yoon Ju Jung, Ji Hyun Kim, Cho Hyun Park, Han Hong Lee
    Journal of Gastrointestinal Surgery.2018; 22(4): 578.     CrossRef
  • Oncologic outcomes of adjuvant chemotherapy alone after radical surgery for stage IB–IIA cervical cancer patients
    Kwang-Beom Lee, Young Saing Kim, Jong-Min Lee
    Journal of Gynecologic Oncology.2018;[Epub]     CrossRef
  • Awareness of and Attitudes toward Human Papillomavirus Vaccination among Adults in Korea: 9-Year Changes in Nationwide Surveys
    Jin-Kyoung Oh, Bo Yoon Jeong, E Hwa Yun, Min Kyung Lim
    Cancer Research and Treatment.2018; 50(2): 436.     CrossRef
  • Curcuzedoalide contributes to the cytotoxicity of Curcuma zedoaria rhizomes against human gastric cancer AGS cells through induction of apoptosis
    Eun Bee Jung, Tuy An Trinh, Tae Kyoung Lee, Noriko Yamabe, Ki Sung Kang, Ji Hoon Song, Sungyoul Choi, Sanghyun Lee, Tae Su Jang, Ki Hyun Kim, Gwi Seo Hwang
    Journal of Ethnopharmacology.2018; 213: 48.     CrossRef
  • Socioeconomic differences in self- and family awareness of viral hepatitis status among carriers of hepatitis B or C in rural Korea
    Hye-Ran Ahn, Sung-Bum Cho, Ik Joo Chung, Sun-Seog Kweon
    American Journal of Infection Control.2018; 46(3): 328.     CrossRef
  • Detection of early stage prostate cancer by using a simple carbon nanotube@paper biosensor
    Sungkyung Ji, Myeongsoon Lee, Don Kim
    Biosensors and Bioelectronics.2018; 102: 345.     CrossRef
  • Allogeneic hematopoietic cell transplantation for lymphoma: baseline and posttransplant prognostic factors
    Sun-Hye Ko, Jung-Hee Lee, Je-Hwan Lee, Han-Seung Park, Eun-Ji Choi, Miee Seol, Young-Shin Lee, Young-Ah Kang, Mijin Jeon, Kyoo-Hyung Lee
    Leukemia & Lymphoma.2018; 59(8): 1829.     CrossRef
  • Phase II Study of BGJ398 in Patients With FGFR-Altered Advanced Cholangiocarcinoma
    Milind Javle, Maeve Lowery, Rachna T. Shroff, Karl Heinz Weiss, Christoph Springfeld, Mitesh J. Borad, Ramesh K. Ramanathan, Lipika Goyal, Saeed Sadeghi, Teresa Macarulla, Anthony El-Khoueiry, Robin Kate Kelley, Ivan Borbath, Su Pin Choo, Do-Youn Oh, Phil
    Journal of Clinical Oncology.2018; 36(3): 276.     CrossRef
  • Growing incidence of thyroid carcinoma in recent years: Factors underlying overdiagnosis
    Alvaro Sanabria, Luiz P. Kowalski, Jatin P. Shah, Iain J. Nixon, Peter Angelos, Michelle D. Williams, Alessandra Rinaldo, Alfio Ferlito
    Head & Neck.2018; 40(4): 855.     CrossRef
  • Effect of Area-Level Deprivation on Cancer Survival Time: A Register-Based Follow-up Study of 145 585 Korean Subjects
    Minjung Kwak, Changhoon Kim
    Asia Pacific Journal of Public Health.2018; 30(1): 19.     CrossRef
  • Discordances in ER, PR, and HER2 between primary breast cancer and brain metastasis
    Jaehag Jung, Seung Hoon Lee, Mira Park, Ji Hye Youn, Sang Hoon Shin, Ho Shin Gwak, Heon Yoo
    Journal of Neuro-Oncology.2018; 137(2): 295.     CrossRef
  • Comparative evaluation of the Omniplex-HPV and RFMP HPV PapilloTyper for detecting human papillomavirus genotypes in cervical specimens
    Young Ahn Yoon, Bo-Hyun Kim, Su-Hak Heo, Hwi Jun Kim, Young-Jin Choi
    Archives of Virology.2018; 163(4): 969.     CrossRef
  • Anatomical distribution and detection rate of colorectal neoplasms according to age in the colonoscopic screening of a Korean population
    Suk-young Lee, Wan Hee Song, Sang Cheul Oh, Byung-Wook Min, Sun Il Lee
    Annals of Surgical Treatment and Research.2018; 94(1): 36.     CrossRef
  • Incidence of venous thromboembolism in Korea from 2009 to 2013
    Junshik Hong, Ju Hyun Lee, Ho-Young Yhim, Won-Il Choi, Soo-Mee Bang, Heeyoung Lee, Doyeun Oh, Christophe Leroyer
    PLOS ONE.2018; 13(1): e0191897.     CrossRef
  • Epidemiology of Intracranial Metastases in Korea: A National Cohort Investigation
    Tackeun Kim, Changhoon Song, Jung Ho Han, In-Ah Kim, Yu Jung Kim, Se Hyun Kim, Jee Hyun Kim, Chae-Yong Kim
    Cancer Research and Treatment.2018; 50(1): 164.     CrossRef
  • Second Primary Cancer Risk among Kidney Cancer Patients in Korea: A Population-Based Cohort Study
    Jae Young Joung, Whi-An Kwon, Jiwon Lim, Chang-Mo Oh, Kyu-Won Jung, Sung Han Kim, Ho Kyung Seo, Weon Seo Park, Jinsoo Chung, Kang Hyun Lee, Young-Joo Won
    Cancer Research and Treatment.2018; 50(1): 293.     CrossRef
  • Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity
    Ho Jin Lee, Phuong Chi Pham, Seung Yeob Hyun, Byungyeob Baek, Byungjin Kim, Yunha Kim, Hye-Young Min, Jeeyeon Lee, Ho-Young Lee
    Molecular Cancer.2018;[Epub]     CrossRef
  • Low dietary energy intake is associated with sarcopenia in cancer survivors: An analysis based on the Korean National Health and Nutrition Examination Survey 2008–2011
    Hyoeun Kim, Sunmi Yoo, Yong Soon Park, Seung Guk Park
    Nutrition Research.2018; 53: 15.     CrossRef
  • Clinical significance of computed tomography-detected ascites in gastric cancer patients with peritoneal metastases
    Su Hwan Kim, Young Ho Choi, Ji Won Kim, Sohee Oh, Seohui Lee, Byeong Gwan Kim, Kook Lae Lee
    Medicine.2018; 97(8): e9343.     CrossRef
  • Interaction between alcohol consumption and methylenetetrahydrofolate reductase polymorphisms in thyroid cancer risk: National Cancer Center cohort in Korea
    Sarah Yang, Jeonghee Lee, Yoon Park, Eun Kyung Lee, Yul Hwangbo, Junsun Ryu, Joohon Sung, Jeongseon Kim
    Scientific Reports.2018;[Epub]     CrossRef
  • Clinical Outcomes of Standard Triple Therapy Plus Probiotics or Concomitant Therapy for Helicobacter pylori Infection
    Jae Hyun Jung, In Kuk Cho, Chang Hee Lee, Gwan Gyu Song, Ji Hyun Lim
    Gut and Liver.2018; 12(2): 165.     CrossRef
  • Novel Systemic Therapies for Advanced Gastric Cancer
    Hong Jun Kim, Sang Cheul Oh
    Journal of Gastric Cancer.2018; 18(1): 1.     CrossRef
  • The role of bevacizumab on tumour angiogenesis and in the management of gynaecological cancers: A review
    Dinesh Kumar Chellappan, Kun Hooi Leng, Lee Jia Jia, Nur Amirah Binti Abdul Aziz, Wong Chun Hoong, Yap Cheng Qian, Fam Yi Ling, Gwee Sing Wei, Tiong Ying, Jestin Chellian, Gaurav Gupta, Kamal Dua
    Biomedicine & Pharmacotherapy.2018; 102: 1127.     CrossRef
  • Genome‐wide profiling of normal gastric mucosa identifies Helicobacter pylori‐ and cancer‐associated DNA methylome changes
    Hae Dong Woo, Nora Fernandez‐Jimenez, Akram Ghantous, Davide Degli Esposti, Cyrille Cuenin, Vincent Cahais, Il Ju Choi, Young‐Il Kim, Jeongseon Kim, Zdenko Herceg
    International Journal of Cancer.2018; 143(3): 597.     CrossRef
  • Efficacy of a clinical pathway for patients with thyroid cancer
    Hyungju Kwon, Joon‐Hyop Lee, Joohyun Woo, Woosung Lim, Byung‐In Moon, Nam Sun Paik
    Head & Neck.2018; 40(9): 1909.     CrossRef
  • Associations between genetic polymorphisms of membrane transporter genes and prognosis after chemotherapy: meta-analysis and finding from Seoul Breast Cancer Study (SEBCS)
    Ji-Eun Kim, Jaesung Choi, JooYong Park, Chulbum Park, Se Mi Lee, Seong Eun Park, Nan Song, Seokang Chung, Hyuna Sung, Wonshik Han, Jong Won Lee, Sue K. Park, Mi Kyung Kim, Dong-Young Noh, Keun-Young Yoo, Daehee Kang, Ji-Yeob Choi
    The Pharmacogenomics Journal.2018; 18(5): 633.     CrossRef
  • Long-term survival of patients with thyroid cancer according to the methods of tumor detection: A nationwide cohort study in Korea
    Yuh-Seog Jung, Chang-Mo Oh, Yeol Kim, Kyu-Won Jung, Junsun Ryu, Young-Joo Won, Pierlorenzo Pallante
    PLOS ONE.2018; 13(4): e0194743.     CrossRef
  • Clinical impact of boost irradiation to pelvic lymph node in uterine cervical cancer treated with definitive chemoradiotherapy
    Kyu Hye Choi, Ji Yoon Kim, Dong Soo Lee, Yun Hee Lee, Sea-Won Lee, SooYoon Sung, Hee Hyun Park, Sei-Chul Yoon, Soo Young Hur, Jong-Sup Park, Yeon Sil Kim
    Medicine.2018; 97(16): e0517.     CrossRef
  • Risk factors for hepatocellular carcinoma by age, sex, and liver disorder status: A prospective cohort study in Korea
    Sang‐Wook Yi, Ja‐Sung Choi, Jee‐Jeon Yi, Yong‐ho Lee, Ki Jun Han
    Cancer.2018; 124(13): 2748.     CrossRef
  • The Effectiveness of Problem-Solving Therapy Program Intervention in Reducing Depression of Older Cancer Patients
    Hyunsook Yoon, Yojin Kim, Kyoungwon Choi, Yeon Ok Lim, Ilsung Nam, Woonjeong Kim, Hyejin Ham
    Korean Journal of Health Promotion.2018; 18(1): 60.     CrossRef
  • A panel consisting of three novel circulating lncRNAs, is it a predictive tool for gastric cancer?
    Jingjing Liu, Jiajun Wang, Yongxi Song, Bin Ma, Junlong Luo, Zhongran Ni, Peng Gao, Jingxu Sun, Junhua Zhao, Xiaowan Chen, Zhenning Wang
    Journal of Cellular and Molecular Medicine.2018; 22(7): 3605.     CrossRef
  • Hierarchical structural component modeling of microRNA-mRNA integration analysis
    Yongkang Kim, Sungyoung Lee, Sungkyoung Choi, Jin-Young Jang, Taesung Park
    BMC Bioinformatics.2018;[Epub]     CrossRef
  • Projection of Breast Cancer Burden due to Reproductive/Lifestyle Changes in Korean Women (2013-2030) Using an Age-Period-Cohort Model
    Joo Eun Lee, Sang Ah Lee, Tae Hyun Kim, Sohee Park, Yoon Soo Choy, Yeong Jun Ju, Eun-Cheol Park
    Cancer Research and Treatment.2018; 50(4): 1388.     CrossRef
  • Dietary pattern and health-related quality of life among breast cancer survivors
    Na-Hui Kim, Sihan Song, So-Youn Jung, Eunsook Lee, Zisun Kim, Hyeong-Gon Moon, Dong-Young Noh, Jung Eun Lee
    BMC Women's Health.2018;[Epub]     CrossRef
  • Trends in Gallbladder Cancer Incidence and Survival in Korea
    Youngjun Wi, Hyeongtaek Woo, Young-Joo Won, Jin-Young Jang, Aesun Shin
    Cancer Research and Treatment.2018; 50(4): 1444.     CrossRef
  • Development of an Algorithm for Stroke Prediction: A National Health Insurance Database Study in Korea
    Seung Nam Min, Se Jin Park, Dong Joon Kim, Murali Subramaniyam, Kyung-Sun Lee
    European Neurology.2018; 79(3-4): 214.     CrossRef
  • Oral administration of herbal medicines for radiation pneumonitis in lung cancer patients: A systematic review and meta-analysis
    Kwan-Il Kim, Ji Hee Jun, Hyunjung Baek, Jae-Hyo Kim, Beom-Joon Lee, Hee-Jae Jung, Francesca Borrelli
    PLOS ONE.2018; 13(5): e0198015.     CrossRef
  • A prospective pilot evaluation of vaginal and urine self-sampling for the Roche cobas 4800 HPV test for cervical cancer screening
    Sang-Hyun Hwang, Hye Young Shin, Dong Ock Lee, Na Young Sung, Bomyee Lee, Do-Hoon Lee, Jae Kwan Jun
    Scientific Reports.2018;[Epub]     CrossRef
  • Incidence of Diabetes After Cancer Development
    Yul Hwangbo, Danbee Kang, Minwoong Kang, Saemina Kim, Eun Kyung Lee, Young Ae Kim, Yoon Jung Chang, Kui Son Choi, So-Youn Jung, Sang Myung Woo, Jin Seok Ahn, Sung Hoon Sim, Yun Soo Hong, Roberto Pastor-Barriuso, Eliseo Guallar, Eun Sook Lee, Sun-Young Kon
    JAMA Oncology.2018; 4(8): 1099.     CrossRef
  • Effect of psychosocial interventions on the quality of life of patients with colorectal cancer: a systematic review and meta-analysis
    Heesook Son, Youn-Jung Son, Hyerang Kim, Yoonju Lee
    Health and Quality of Life Outcomes.2018;[Epub]     CrossRef
  • Are pregnancy, parity, menstruation and breastfeeding risk factors for thyroid cancer? Results from the Korea National Health and Nutrition Examination Survey, 2010‐2015
    Hosu Kim, Kyong Young Kim, Jong Ha Baek, Jaehoon Jung
    Clinical Endocrinology.2018; 89(2): 233.     CrossRef
  • Estimation of the medical need for carbon-ion radiotherapy in Korea
    Ilsung Cho, Young Seok Seo, WonGyun Jung, Mi-sook Kim
    Journal of Radiation Research.2018; 59(5): 588.     CrossRef
  • Lung Cancer Screening with Low-Dose CT in Female Never Smokers: Retrospective Cohort Study with Long-term National Data Follow-up
    Hyae Young Kim, Kyu-Won Jung, Kun Young Lim, Soo-Hyun Lee, Jae Kwan Jun, Jeongseon Kim, Bin Hwangbo, Jin Soo Lee
    Cancer Research and Treatment.2018; 50(3): 748.     CrossRef
  • The Impact of Surgical Timing on Pathologic Tumor Response after Short Course and Long Course Preoperative Chemoradiation for Locally Advanced Rectal Adenocarcinoma
    Sea-Won Lee, Jong Hoon Lee, In Kyu Lee, Seong Taek Oh, Dae Yong Kim, Tae Hyun Kim, Jae Hwan Oh, Ji Yeon Baek, Hee Jin Chang, Hee Chul Park, Hee Cheol Kim, Eui Kyu Chie, Taek-Keun Nam, Hong Seok Jang
    Cancer Research and Treatment.2018; 50(3): 1039.     CrossRef
  • Nationwide Trends in the Incidence of Melanoma and Non-melanoma Skin Cancers from 1999 to 2014 in South Korea
    Chang-Mo Oh, Hyunsoon Cho, Young-Joo Won, Hyun-Joo Kong, Yun Ho Roh, Ki-Heon Jeong, Kyu-Won Jung
    Cancer Research and Treatment.2018; 50(3): 729.     CrossRef
  • Utility of the National Lung Screening Trial Criteria for Estimation of Lung Cancer in the Korean Population
    Ye Jin Lee, Sun Mi Choi, Jinwoo Lee, Chang-Hoon Lee, Sang-Min Lee, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Young Sik Park
    Cancer Research and Treatment.2018; 50(3): 950.     CrossRef
  • The Effect of Hospice Consultation on Aggressive Treatment of Lung Cancer
    Shin Hye Yoo, Bhumsuk Keam, Miso Kim, Tae Min Kim, Dong-Wan Kim, Dae Seog Heo
    Cancer Research and Treatment.2018; 50(3): 720.     CrossRef
  • The neutrophil-to-lymphocyte ratio makes the Heng risk model improve better the prediction of overall survival in metastatic renal cell cancer patients
    Sung Han Kim, Whi-An Kwon, Sohee Kim, Jae Young Joung, Ho Kyung Seo, Kang Hyun Lee, Jinsoo Chung
    Japanese Journal of Clinical Oncology.2018; 48(9): 835.     CrossRef
  • Risk of Coronary Heart Disease and Ischemic Stroke Incidence in Gastric Cancer Survivors: A Nationwide Study in Korea
    Dong Wook Shin, Beomseok Suh, Youngmin Park, Hyunsun Lim, Yun-Suhk Suh, Jae Moon Yun, BeLong Cho, Han-Kwang Yang
    Annals of Surgical Oncology.2018; 25(11): 3248.     CrossRef
  • Prognostic Factors of Penile Cancer and the Efficacy of Adjuvant Treatment after Penectomy: Results from a Multi-institution Study
    Jong Won Kim, Young Sig Kim, Woo Jin Ko, Young Deuk Choi, Sung Joon Hong, Byung Ha Chung, Kwang Suk Lee
    Journal of Korean Medical Science.2018;[Epub]     CrossRef
  • Incidence of gallstones after gastric resection for gastric cancer: a nationwide claims-based study
    Gi Hyeon Seo, Chang-Sup Lim, Young Jun Chai
    Annals of Surgical Treatment and Research.2018; 95(2): 87.     CrossRef
  • Fermented Ganjangs (Soy Sauce and Sesame Sauce) Attenuates Colonic Carcinogenesis in Azoxymethane/Dextran Sodium Sulfate-Treated C57BL/6J Mice
    Jia-Le Song, Jung-Ho Choi, Jae-Hoon Seo, Kun-Young Park
    Journal of Medicinal Food.2018; 21(9): 905.     CrossRef
  • Prognostic significance of CT-determined sarcopenia in patients with advanced gastric cancer
    Jong Soo Lee, Young Saing Kim, Eun Young Kim, Wook Jin, Cesario Bianchi
    PLOS ONE.2018; 13(8): e0202700.     CrossRef
  • FOXO3a expression is associated with lymph node metastasis and poor disease-free survival in triple-negative breast cancer
    Abdul Rehman, Yeseul Kim, Hyunsung Kim, Jongmin Sim, Hyein Ahn, Min Sung Chung, Su-Jin Shin, Kiseok Jang
    Journal of Clinical Pathology.2018; 71(9): 806.     CrossRef
  • High RNA-binding Motif Protein 3 Expression Is Associated with Improved Clinical Outcomes in Invasive Breast Cancer
    Sun Hee Kang, Jihyoung Cho, Hasong Jeong, Sun Young Kwon
    Journal of Breast Cancer.2018; 21(3): 288.     CrossRef
  • Outcomes of liver resection in patients with colorectal liver metastases by laparoscopic or open surgery
    Jae-Ryong Shim, Seung Duk Lee, Hyung-Min Park, Eung-Chang Lee, Boram Park, Sung-Sik Han, Seong Hoon Kim, Sang Jae Park
    Annals of Hepato-Biliary-Pancreatic Surgery.2018; 22(3): 223.     CrossRef
  • Hepatitis B Virus Infection Is Independently Associated With Advanced Colorectal Adenoma
    Su Hwan Kim, Ji Won Kim, Kook Lae Lee, Seohui Lee, Seong-Joon Koh, Ji Bong Jeong, Byeong Gwan Kim
    The American Journal of the Medical Sciences.2018; 356(2): 141.     CrossRef
  • Analysis of red blood cell use in elective surgeries over 12 years in Korea
    Banseok Kim, Yongjung Park, Young Ah Kim, Minjin Kang, Sinyoung Kim, Hyun Ok Kim
    Transfusion.2018; 58(10): 2335.     CrossRef
  • Effect of tibolone on the survival of early stage cervical adenocarcinoma patients
    Seung-Ho Lee, Yoon-Jin Cho, Kyung-Joo Cho, Mee-Hyang Ko, Sun-Young Jung, Seung-Joo Chon, So-Yi Lim, Kwang-Beom Lee
    Obstetrics & Gynecology Science.2018; 61(5): 584.     CrossRef
  • Trend analysis of major cancer statistics according to sex and severity levels in Korea
    Minsu Ock, Woong Jae Choi, Min-Woo Jo, Antonio Palazón-Bru
    PLOS ONE.2018; 13(9): e0203110.     CrossRef
  • Noncontrast magnetic resonance imaging versus ultrasonography for hepatocellular carcinoma surveillance (MIRACLE-HCC): study protocol for a prospective randomized trial
    Chansik An, Do Young Kim, Jin-Young Choi, Kwang Hyub Han, Yun Ho Roh, Myeong-Jin Kim
    BMC Cancer.2018;[Epub]     CrossRef
  • The evaluation of changes in peripheral neuropathy and quality-of-life using low-frequency electrostimulation in patients treated with chemotherapy for breast cancer: a study protocol
    Chang eun Jang, Mi Sook Jung, Eun Hee Sohn, Mijung Kim, Hwa-Seung Yoo, Kyeore Bae, Je Ryong Kim, Jin Sun Lee
    Trials.2018;[Epub]     CrossRef
  • Nationwide Analysis of Treatment Patterns for Korean Breast Cancer Survivors Using National Health Insurance Service Data
    Il Yong Chung, Jihyoun Lee, Suyeon Park, Jong Won Lee, Hyun Jo Youn, Jung Hwa Hong, Ho Hur
    Journal of Korean Medical Science.2018;[Epub]     CrossRef
  • Usefulness of dynamic risk stratification in pediatric patients with differentiated thyroid carcinoma
    Kwangsoon Kim, Won Woong Kim, Jung Bum Choi, Min Jhi Kim, Cho Rok Lee, Jandee Lee, Sang-Wook Kang, Kee-Hyun Nam, Woong Youn Chung, Jong Ju Jeong
    Annals of Surgical Treatment and Research.2018; 95(4): 222.     CrossRef
  • Secondary Breast, Ovarian, and Uterine Cancers After Colorectal Cancer: A Nationwide Population-Based Cohort Study in Korea
    Dong Woo Shin, Yoon Jin Choi, Hyun Soo Kim, Kyung-Do Han, Hyuk Yoon, Young Soo Park, Nayoung Kim, Dong Ho Lee
    Diseases of the Colon & Rectum.2018; 61(11): 1250.     CrossRef
  • The da Vinci Xi System in Robotic Gastric Cancer Surgery: A Comparison with the S System
    Chulhyo Jeon, Ho Seok Seo, Yoon Ju Jung, Cho Hyun Park, Kyo Young Song
    The Journal of Minimally Invasive Surgery.2018; 21(3): 112.     CrossRef
  • Induction of apoptosis and G1 phase cell cycle arrest by Aster�incises in AGS gastric adenocarcinoma cells
    Daniel Ngabire, Yeong-Ae Seong, Maheshkumar Prakash Patil, Irvine Niyonizigiye, Yong Bae Seo, Gun-Do Kim
    International Journal of Oncology.2018;[Epub]     CrossRef
  • Role of human epididymis protein 4 in chemoresistance and prognosis of epithelial ovarian cancer
    Seungho Lee, Seowon Choi, Yookyung Lee, Donghae Chung, Suntaek Hong, Nohhyun Park
    Journal of Obstetrics and Gynaecology Research.2017; 43(1): 220.     CrossRef
  • Effect of number of retrieved lymph nodes on prognosis in FIGO stage IB–IIA cervical cancer patients treated with primary radical surgery
    Soyi Lim, Kyungjoo Cho, Seungho Lee, Kwangbeom Lee, Jinwoo Shin, Donghae Chung, Chanyong Park
    Journal of Obstetrics and Gynaecology Research.2017; 43(1): 211.     CrossRef
  • Long-Term Outcome of Distal Cholangiocarcinoma after Pancreaticoduodenectomy Followed by Adjuvant Chemoradiotherapy: A 15-Year Experience in a Single Institution
    Byoung Hyuck Kim, Kyubo Kim, Eui Kyu Chie, Jeanny Kwon, Jin-Young Jang, Sun Whe Kim, Do-Youn Oh, Yung-Jue Bang
    Cancer Research and Treatment.2017; 49(2): 473.     CrossRef
  • Suicidal ideation and suicidal attempts among adults with chronic diseases: A cross-sectional study
    Su-Yeon Kye, Keeho Park
    Comprehensive Psychiatry.2017; 73: 160.     CrossRef
  • 5-Fluorouracil inhibits cell migration by induction of Sestrin2 in colon cancer cells
    Kyuhwa Seo, Sung Hwan Ki, Eun Young Park, Sang Mi Shin
    Archives of Pharmacal Research.2017; 40(2): 231.     CrossRef
  • Psychiatric comorbidities among breast cancer survivors in South Korea: a nationwide population-based study
    Jaesung Heo, Mison Chun, Young-Taek Oh, O. Kyu Noh, Logyoung Kim
    Breast Cancer Research and Treatment.2017; 162(1): 151.     CrossRef
  • Atrophic and Metaplastic Progression in the Background Mucosa of Patients with Gastric Adenoma
    Hee Kyong Na, Charles J. Cho, Suh Eun Bae, Jeong Hoon Lee, Young Soo Park, Ji Yong Ahn, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Se Jin Jang, Hwoon-Yong Jung, Pal Bela Szecsi
    PLOS ONE.2017; 12(1): e0169456.     CrossRef
  • 125I–F56 Peptide as Radioanalysis Agent Targeting VEGFR1 in Mice Xenografted with Human Gastric Tumor
    Hua Zhu, Chuanke Zhao, Fei Liu, Lixin Wang, Junnan Feng, Chengchao Shou, Zhi Yang
    ACS Medicinal Chemistry Letters.2017; 8(2): 266.     CrossRef
  • Thyroid fine-needle aspiration biopsy positively correlates with increased diagnosis of thyroid cancer in South Korean patients
    Yoon Jae Cho, Do Young Kim, Eun-Cheol Park, Kyu-Tae Han
    BMC Cancer.2017;[Epub]     CrossRef
  • Survival Rate and Associated Factors of Childhood Leukemia in Iran: A Systematic Review and Meta Analysis
    Yousef Veisani, Ali Delpisheh
    Journal of Pediatrics Review.2017;[Epub]     CrossRef
  • Effects of hormone receptor status on the durable response of trastuzumab-based therapy in metastatic breast cancer
    Hyung Soon Park, Joohyuk Sohn, Seung Il Kim, Seho Park, Hyung Seok Park, Seul Ghi Gho, Hyun Cheol Chung, Soonmyung Paik, Gun Min Kim
    Breast Cancer Research and Treatment.2017; 163(2): 255.     CrossRef
  • Usefulness of AFP, AFP-L3, and PIVKA-II, and their combinations in diagnosing hepatocellular carcinoma
    Sang Joon Park, Jae Young Jang, Soung Won Jeong, Young Kyu Cho, Sae Hwan Lee, Sang Gyune Kim, Sang-Woo Cha, Young Seok Kim, Young Deok Cho, Hong Soo Kim, Boo Sung Kim, Suyeon Park, Hae In Bang
    Medicine.2017; 96(11): e5811.     CrossRef
  • Outcomes of laparoscopic surgery in pathologic T4 colon cancers compared to those of open surgery
    Jeonghyun Kang, Seung Hyuk Baik, Kang Young Lee, Seung-Kook Sohn
    International Journal of Colorectal Disease.2017; 32(4): 531.     CrossRef
  • The Effect of Endoscopic Resection on Short-Term Surgical Outcomes in Patients with Additional Laparoscopic Gastrectomy after Non-Curative Resection for Gastric Cancer
    Eun-Gyeong Lee, Keun-Won Ryu, Bang-Wool Eom, Hong-Man Yoon, Yong-Il Kim, Soo-Jeong Cho, Jong-Yeul Lee, Chan-Gyoo Kim, Il-Ju Choi, Young-Woo Kim
    Journal of Gastric Cancer.2017; 17(1): 33.     CrossRef
  • Molecular Testing for Gastrointestinal Cancer
    Hye Seung Lee, Woo Ho Kim, Yoonjin Kwak, Jiwon Koh, Jeong Mo Bae, Kyoung-Mee Kim, Mee Soo Chang, Hye Seung Han, Joon Mee Kim, Hwal Woong Kim, Hee Kyung Chang, Young Hee Choi, Ji Y. Park, Mi Jin Gu, Min Jin Lhee, Jung Yeon Kim, Hee Sung Kim, Mee-Yon Cho
    Journal of Pathology and Translational Medicine.2017; 51(2): 103.     CrossRef
  • Mesothelin Expression in Gastric Adenocarcinoma and Its Relation to Clinical Outcomes
    Song-Hee Han, Mee Joo, Hanseong Kim, Sunhee Chang
    Journal of Pathology and Translational Medicine.2017; 51(2): 122.     CrossRef
  • The light and shade of the cancer care system in Korea
    Byung Soh Min
    Journal of the Korean Medical Association.2017; 60(3): 217.     CrossRef
  • Proposal for improving the outcomes of cancer treatment
    Hyung Jin Kim
    Journal of the Korean Medical Association.2017; 60(3): 219.     CrossRef
  • Genetic Predisposition of Polymorphisms inHMGB1-Related Genes to Breast Cancer Prognosis in Korean Women
    Junsu Lee, Jaesung Choi, Seokang Chung, JooYong Park, Ji-Eun Kim, Hyuna Sung, Wonshik Han, Jong Won Lee, Sue K. Park, Mi Kyung Kim, Sei-Hyun Ahn, Dong-Young Noh, Keun-Young Yoo, Daehee Kang, Ji-Yeob Choi
    Journal of Breast Cancer.2017; 20(1): 27.     CrossRef
  • Long-term outcomes after salvage radiotherapy for postoperative locoregionally recurrent non-small-cell lung cancer
    Eunji Kim, Changhoon Song, Mi Young Kim, Jae-Sung Kim
    Radiation Oncology Journal.2017; 35(1): 55.     CrossRef
  • Basic Facts of Breast Cancer in Korea in 2014: The 10-Year Overall Survival Progress
    Eun Hwa Park, Sun Young Min, Zisun Kim, Chan Seok Yoon, Kyu-Won Jung, Seok Jin Nam, Se Jeong Oh, Seeyoun Lee, Byeong-Woo Park, Woosung Lim, Min Hee Hur
    Journal of Breast Cancer.2017; 20(1): 1.     CrossRef
  • Factors Affecting the “Locus of Responsibility” in Cancer News: Focusing on the Role of Health Journalists’ Medical Expertise in South Korea
    Yong-Chan Kim, Minsun Shim, Jee Hyun Kim, Keeho Park
    Journalism & Mass Communication Quarterly.2017; 94(2): 465.     CrossRef
  • Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2014
    Kyu-Won Jung, Young-Joo Won, Chang-Mo Oh, Hyun-Joo Kong, Duk Hyoung Lee, Kang Hyun Lee
    Cancer Research and Treatment.2017; 49(2): 292.     CrossRef
  • Prediction of Cancer Incidence and Mortality in Korea, 2017
    Kyu-Won Jung, Young-Joo Won, Chang-Mo Oh, Hyun-Joo Kong, Duk Hyoung Lee, Kang Hyun Lee
    Cancer Research and Treatment.2017; 49(2): 306.     CrossRef
  • The gene copy number of c-MET has a significant impact on progression-free survival in Korean patients with ovarian carcinoma
    Wook Youn Kim, Seung-Hyuk Shim, Ho Young Jung, Meari Dong, Soo-Nyung Kim, Sun Joo Lee
    Human Pathology.2017; 64: 98.     CrossRef
  • Semi‐end‐to‐end esophagojejunostomy after laparoscopy‐assisted total gastrectomy better reduces stricture and leakage than the conventional end‐to‐side procedure: A retrospective study
    Wei Duan, Kaijun Liu, Xiaolong Fu, Xuqi Shen, Jun Chen, Chongyu Su, Peiwu Yu, Yongliang Zhao
    Journal of Surgical Oncology.2017; 116(2): 177.     CrossRef
  • Occipital Lobe Metastasis of Hepatocellular Carcinoma Presenting as Homonymous Hemianopia
    Hye Jin Lee, Young Hee Maeng, Jinho Jeong, You-Nam Chung, Chang Sub Lee, Byung-Cheol Song
    Journal of the Korean Ophthalmological Society.2017; 58(4): 488.     CrossRef
  • Psycho-oncology in Korea: past, present and future
    Hyun Jeong Lee, Kwang-Min Lee, Dooyoung Jung, Eun-Jung Shim, Bong-Jin Hahm, Jong-Heun Kim
    BioPsychoSocial Medicine.2017;[Epub]     CrossRef
  • Risk factors and the preoperative assessment of right para-oesophageal lymph node metastasis in right lobe papillary thyroid carcinoma: A case series
    You Qu, Hao Zhang, Ping Zhang, Wenwu Dong, Liang He, Wei Sun, Jinhao Liu
    International Journal of Surgery.2017; 42: 123.     CrossRef
  • Care Pathway for Cancer Survivorship in Korea: Trend of Breast Cancer Pathway from 2003 to 2010
    Hwa Jeong Seo, Dong Yong Noh
    Healthcare Informatics Research.2017; 23(2): 119.     CrossRef
  • Practice Patterns of Hereditary Ovarian Cancer Management in Korea
    Min Chul Choi, Myong Cheol Lim, Maria Lee, Min Kyu Kim, Dong Hoon Suh, Yong Jung Song, Tae-Joong Kim, Suk-Joon Chang, Jae-Weon Kim
    International Journal of Gynecological Cancer.2017; 27(5): 895.     CrossRef
  • Isofraxidin inhibited proliferation and induced apoptosis via blockage of Akt pathway in human colorectal cancer cells
    Peng Shen, Hong-Gang Wang, Miao-Miao Li, Qian-Yun Ma, Chuan-Wen Zhou, Feng Pan, Rui Xie
    Biomedicine & Pharmacotherapy.2017; 92: 78.     CrossRef
  • Micrometastasis in Gastric Cancer
    Gun Jung Youn, Woo Chul Chung
    The Korean Journal of Gastroenterology.2017; 69(5): 270.     CrossRef
  • Incorporating Erlotinib or Irinotecan Plus Cisplatin into Chemoradiotherapy for Stage III Non-small Cell Lung Cancer According to EGFR Mutation Status
    Youngjoo Lee, Ji-Youn Han, Sung Ho Moon, Byung-Ho Nam, Kun Young Lim, Geon Kook Lee, Heung Tae Kim, Tak Yun, Hye Jin An, Jin Soo Lee
    Cancer Research and Treatment.2017; 49(4): 981.     CrossRef
  • Treatment of Refractory Colorectal Cancer: Regorafenib vs. TAS-102
    Jae Ho Jeong, Yong Sang Hong, Tae Won Kim
    Current Colorectal Cancer Reports.2017; 13(4): 325.     CrossRef
  • Hormone Therapy for Metastatic Breast Cancer
    Seok Yun Kang
    The Korean Journal of Medicine.2017; 92(3): 251.     CrossRef
  • Prognostic impact of Ki-67 in patients with gastric cancer—the importance of depth of invasion and histologic differentiation
    Gyung Hyuck Ko, Se-Il Go, Won Sup Lee, Jeong-Hee Lee, Sang-Ho Jeong, Young-Joon Lee, Soon Chan Hong, Woo Song Ha
    Medicine.2017; 96(25): e7181.     CrossRef
  • Clinical characteristics of second primary pancreatic cancer
    Jung Hyun Jo, In Rae Cho, Jang Han Jung, Hee Seung Lee, Moon Jae Chung, Seungmin Bang, Seung Woo Park, Jae Bock Chung, Si Young Song, Jeong Youp Park, Masaru Katoh
    PLOS ONE.2017; 12(6): e0179784.     CrossRef
  • Effects of Soy Product Intake and Interleukin Genetic Polymorphisms on Early Gastric Cancer Risk in Korea: A Case-Control Study
    Sarah Yang, Yoon Park, Jeonghee Lee, Il Ju Choi, Young Woo Kim, Keun Won Ryu, Joohon Sung, Jeongseon Kim
    Cancer Research and Treatment.2017; 49(4): 1044.     CrossRef
  • Prognostic Factors and Scoring Model for Survival in Metastatic Biliary Tract Cancer
    Hyung Soon Park, Ji Soo Park, You Jin Chun, Yun Ho Roh, Jieun Moon, Hong Jae Chon, Hye Jin Choi, Joon Seong Park, Dong Ki Lee, Se-Joon Lee, Dong Sup Yoon, Hei-Cheul Jeung
    Cancer Research and Treatment.2017; 49(4): 1127.     CrossRef
  • Sex-specific incidence of EGFR mutation and its association with age and obesity in lung adenocarcinomas: a retrospective analysis
    Hye-Ryoun Kim, Seo Yun Kim, Cheol Hyeon Kim, Sung Hyun Yang, Jae Cheol Lee, Chang-Min Choi, Im Il Na
    Journal of Cancer Research and Clinical Oncology.2017; 143(11): 2283.     CrossRef
  • A Randomized Phase II Study of Leucovorin/5-Fluorouracil with or without Oxaliplatin (LV5FU2 vs. FOLFOX) for Curatively-Resected, Node-Positive Esophageal Squamous Cell Carcinoma
    Sung Hee Lim, Young Mog Shim, Se Hoon Park, Hong Kwan Kim, Young Soo Choi, Myung-Ju Ahn, Keunchil Park, Jae Ill Zo, Jong-Mu Sun
    Cancer Research and Treatment.2017; 49(3): 816.     CrossRef
  • Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer
    Ho-Young Son, Yul Hwangbo, Seong-Keun Yoo, Sun-Wha Im, San Duk Yang, Soo-Jung Kwak, Min Seon Park, Soo Heon Kwak, Sun Wook Cho, Jun Sun Ryu, Jeongseon Kim, Yuh-Seog Jung, Tae Hyun Kim, Su-jin Kim, Kyu Eun Lee, Do Joon Park, Nam Han Cho, Joohon Sung, Jeong
    Nature Communications.2017;[Epub]     CrossRef
  • A randomised phase II study of continuous versus stop-and-go S-1 plus oxaliplatin following disease stabilisation in first-line chemotherapy in patients with metastatic gastric cancer
    Sook Ryun Park, Mi-Jung Kim, Byung-Ho Nam, Chan Gyoo Kim, Jong Yeul Lee, Soo-Jeong Cho, Sun-Young Kong, Young-Iee Park
    European Journal of Cancer.2017; 83: 32.     CrossRef
  • Quality of life among Korean gastrointestinal cancer survivors
    Soojung Ahn, Hyejeong Jung, Sanghee Kim, Sang Joon Shin, Chang Gi Park, Sang Hui Chu
    European Journal of Oncology Nursing.2017; 30: 15.     CrossRef
  • Joint Symposium of Korean Cancer Association & UICC-ARO—Cross-boundary cancer studies: cancer and Universal Health Coverage (UHC) in Asia
    Eun-Cheol Park, Norie Kawahara, Shinjiro Nozaki, Hasbullah Thabrany, Shunya Yoshimi, Sohee Park, Duk Hyoung Lee, Hideyuki Akaza, Jae Kyung Roh
    Japanese Journal of Clinical Oncology.2017; 47(9): 889.     CrossRef
  • The serum pepsinogen levels for risk assessment of gastric neoplasms
    Jun-Hyung Cho, Seong Ran Jeon, Hyun Gun Kim, So-Young Jin, Suyeon Park
    Medicine.2017; 96(29): e7603.     CrossRef
  • Differential proteome expression analysis of androgen-dependent and -independent pathways in LNCaP prostate cancer cells
    Seho Cha, Dong Hoon Shin, Jun Ryeong Seok, Jae Kyung Myung
    Experimental Cell Research.2017; 359(1): 215.     CrossRef
  • Comparison of the Differences in Survival Rates between the 7th and 8th Editions of the AJCC TNM Staging System for Gastric Adenocarcinoma: a Single-Institution Study of 5,507 Patients in Korea
    Sung Geun Kim, Ho Seok Seo, Han Hong Lee, Kyo Yong Song, Cho Hyun Park
    Journal of Gastric Cancer.2017; 17(3): 212.     CrossRef
  • Family history of gastric cancer is associated with the risk of colorectal neoplasia in Korean population
    Yoon Suk Jung, Nam Hee Kim, Hyo-Joon Yang, Soo-Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn
    Digestive and Liver Disease.2017; 49(10): 1155.     CrossRef
  • A Comparison of Symptoms, Depression, and Quality of Life according to Stages of Survivorship in Lung Cancer Patients
    Yoon Jung Chae, Jeong Sook Park
    Asian Oncology Nursing.2017; 17(2): 79.     CrossRef
  • Unusual Contralateral Axillary Lymph Node Metastasis in a Second Primary Breast Cancer Detected by FDG PET/CT and Lymphoscintigraphy
    Ji-Young Kim, Hyunjong Lee, Tae Sung Kim, Han-Sung Kang, Seok-ki Kim
    Nuclear Medicine and Molecular Imaging.2017; 51(4): 350.     CrossRef
  • Changes in standardized mortality rates from thyroid cancer in Korea between 1985 and 2015: Analysis of Korean national data
    Yun Mi Choi, Won Gu Kim, Hyemi Kwon, Min Ji Jeon, Minkyu Han, Tae Yong Kim, Young Kee Shong, Sang Mo Hong, Eun‐Gyoung Hong, Won Bae Kim
    Cancer.2017; 123(24): 4808.     CrossRef
  • Proposal for Comprehensive Quality Control of Heavy-Ion Medical Accelerator
    Dong-wook Kim, Dong-oh Shin, Young-hoon Shin, Hyun-do Heo
    Progress in Medical Physics.2017; 28(2): 67.     CrossRef
  • Estimated future incidence of malignant mesothelioma in South Korea: Projection from 2014 to 2033
    Kyeong Min Kwak, Domyung Paek, Seung-sik Hwang, Young-Su Ju, Mark Allen Pershouse
    PLOS ONE.2017; 12(8): e0183404.     CrossRef
  • Recent advances in pharmacological research on Ecklonia species: a review
    Prashamsa Koirala, Hyun Ah Jung, Jae Sue Choi
    Archives of Pharmacal Research.2017; 40(9): 981.     CrossRef
  • Assessment of the Risk of Colorectal Cancer Survivors Developing a Second Primary Pancreatic Cancer
    Joo Won Chung, Moon Jae Chung, Seungmin Bang, Seung Woo Park, Si Young Song, Jae Bock Chung, Jeong Youp Park
    Gut and Liver.2017; 11(5): 728.     CrossRef
  • Esophageal Squamous Cell Carcinoma Presenting as a Subepithelial Tumor
    Soon Young Kim, Sang Kil Lee, Hyang Joo Ryu
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2017; 17(3): 144.     CrossRef
  • Factors for improving the diagnostic efficiency of the rapid urease test from the gastric corpus
    Jun-Hyung Cho, Seong Ran Jeon, Hyun Gun Kim, So-Young Jin, Suyeon Park
    Scandinavian Journal of Gastroenterology.2017; 52(12): 1320.     CrossRef
  • Updated guidelines on the preoperative staging of thyroid cancer
    Hye Jung Kim
    Ultrasonography.2017; 36(4): 292.     CrossRef
  • Meeting Highlights: The Second Consensus Conference for Breast Cancer Treatment in Korea
    Seeyoun Lee, In Hae Park, Seho Park, Joohyuk Sohn, Joon Jeong, Sung Gwe Ahn, Ik Jae Lee, Hae Kyung Lee, Seung Ah Lee, Won Park, Kyung-Hun Lee, Sung-Won Kim, Sang-Ah Han, Kyung Hae Jung, Byung Ho Son
    Journal of Breast Cancer.2017; 20(3): 228.     CrossRef
  • Validation Study for the Korean Version of Fear of Cancer Recurrence Inventory
    Jinyoung Shin, Aejin Goo, Hyeonyoung Ko, Ji-Hae Kim, Seung-U Lim, Han-Kyeong Lee, Sébastien Simard, Yun-Mi Song
    Journal of Korean Medical Science.2017; 32(11): 1792.     CrossRef
  • Circulating folate levels and colorectal adenoma: a case-control study and a meta-analysis
    Yeong Mi Park, Jiyoung Youn, Chang Ho Cho, Sung Hi Kim, Jung Eun Lee
    Nutrition Research and Practice.2017; 11(5): 419.     CrossRef
  • Current Management of Benign Epithelial Gastric Polyps
    Antonio R. Cheesman, David A. Greenwald, Shailja C. Shah
    Current Treatment Options in Gastroenterology.2017; 15(4): 676.     CrossRef
  • The relationship between drinking alcohol and esophageal, gastric or colorectal cancer: A nationwide population-based cohort study of South Korea
    Yoon Jin Choi, Dong Ho Lee, Kyung-Do Han, Hyun Soo Kim, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim, John Green
    PLOS ONE.2017; 12(10): e0185778.     CrossRef
  • Second primary cancer after liver transplantation in hepatocellular carcinoma: a nationwide population-based study
    Jaesung Heo, O. Kyu Noh, Young-Taek Oh, Mison Chun, Logyoung Kim
    Hepatology International.2017; 11(6): 523.     CrossRef
  • Increasing burden of liver cancer despite extensive use of antiviral agents in a hepatitis B virus‐endemic population
    Jonggi Choi, Seungbong Han, Namkug Kim, Young‐Suk Lim
    Hepatology.2017; 66(5): 1454.     CrossRef
  • Propensity score-matched analysis of the endoscopic bilateral axillo-breast approach (BABA) versus conventional open thyroidectomy in patients with benign or intermediate fine-needle aspiration cytology results, a retrospective study
    Mansoor Alramadhan, Jun Ho Choe, Jun Ho Lee, Jung Han Kim, Jee Soo Kim
    International Journal of Surgery.2017; 48: 9.     CrossRef
  • Multimodal therapy for locally advanced prostate cancer: the roles of radiotherapy, androgen deprivation therapy, and their combination
    Sung Uk Lee, Kwan Ho Cho
    Radiation Oncology Journal.2017; 35(3): 189.     CrossRef
  • Comparison of capecitabine and oxaliplatin with S-1 as adjuvant chemotherapy in stage III gastric cancer after D2 gastrectomy
    Jang Ho Cho, Jae Yun Lim, Jae Yong Cho, Masaru Katoh
    PLOS ONE.2017; 12(10): e0186362.     CrossRef
  • Survival outcome and prognostic factors of neoadjuvant treatment followed by resection for borderline resectable pancreatic cancer
    Hyeong Seok Kim, Jin-Young Jang, Youngmin Han, Kyoung Bun Lee, Ijin Joo, Doo-Ho Lee, Jae Ri Kim, Hongbeom Kim, Wooil Kwon, Sun-Whe Kim
    Annals of Surgical Treatment and Research.2017; 93(4): 186.     CrossRef
  • Experience of Chemotherapy in Ovarian Cancer Patients
    Nayeon Shin, Jiyoung Kim
    Asian Oncology Nursing.2017; 17(3): 158.     CrossRef
  • Establishment of Korean prostate cancer database by the Korean Urological Oncology Society
    Hanjong Ahn, Hyung Jin Kim, Seong Soo Jeon, Cheol Kwak, Gyung Tak Sung, Tae Gyun Kwon, Jong Yeon Park, Sung Hyun Paick
    Investigative and Clinical Urology.2017; 58(6): 434.     CrossRef
  • Accuracy of Preoperative Local Staging of Primary Colorectal Cancer by Using Computed Tomography: Reappraisal Based on Data Collected at a Highly Organized Cancer Center
    Jung Sub So, Chinock Cheong, Seung Yeop Oh, Jei Hee Lee, Young Bae Kim, Kwang Wook Suh
    Annals of Coloproctology.2017; 33(5): 192.     CrossRef
  • Bidirectional alteration of Cav-1 expression is associated with mitogenic conversion of its function in gastric tumor progression
    Byung-Kyu Ryu, Min-Goo Lee, Nam-Hoon Kim, Kil Yeon Lee, Shin-Ju Oh, Jung-Rock Moon, Hyo Jong Kim, Sung-Gil Chi
    BMC Cancer.2017;[Epub]     CrossRef
  • Pancreatic Neuroendocrine Tumor Presenting with Arthritis and Panniculitis
    Hyung Rae Kim, Jae-Sung Ahn, Jin-Hee Noh, Hee-jeong Jeon, Ji Seon Oh, Seung Won Choi, Doo-Ho Lim
    Journal of Rheumatic Diseases.2017; 24(5): 313.     CrossRef
  • Predictors of Psychological Distress Trajectories in the First Year After a Breast Cancer Diagnosis
    Jin-Hee Park, Mison Chun, Yong-Sik Jung, Sun Hyoung Bae
    Asian Nursing Research.2017; 11(4): 268.     CrossRef
  • Dietary Factors and Female Breast Cancer Risk: A Prospective Cohort Study
    Ji Kim, Jeonghee Lee, So-Youn Jung, Jeongseon Kim
    Nutrients.2017; 9(12): 1331.     CrossRef
  • Cancer screening rate in people with diabetes in the Korean population: results from the Korea National Health and Nutrition Examination Survey 2007-2009
    Kumban Walter Chuck, Minji Hwang, Kui Son Choi, Mina Suh, Jae Kwan Jun, Boyoung Park
    Epidemiology and Health.2017; 39: e2017036.     CrossRef
  • Development of second primary cancer in Korean breast cancer survivors
    Hong Kyu Jung, Suyeon Park, Nam Won Kim, Jong Eun Lee, Zisun Kim, Sun Wook Han, Sung Mo Hur, Sung Young Kim, Cheol Wan Lim, Min Hyuk Lee, Jihyoun Lee
    Annals of Surgical Treatment and Research.2017; 93(6): 287.     CrossRef
  • Comparison of outcomes of surgeon-performed intraoperative ultrasonography-guided wire localization and preoperative wire localization in nonpalpable breast cancer patients undergoing breast-conserving surgery
    Young Duck Shin, Young Jin Choi, Dae Hoon Kim, Sung Su Park, Hanlim Choi, Dong Ju Kim, Sungmin Park, Hyo Yung Yun, Young Jin Song
    Medicine.2017; 96(50): e9340.     CrossRef
  • The risk of malignancy and its incidence in early rheumatoid arthritis patients treated with biologic DMARDs
    Soo-Kyung Cho, Jiyoung Lee, Minkyung Han, Sang-Cheol Bae, Yoon-Kyoung Sung
    Arthritis Research & Therapy.2017;[Epub]     CrossRef
  • Disease-Specific Mortality of Differentiated Thyroid Cancer Patients in Korea: A Multicenter Cohort Study
    Min Ji Jeon, Won Gu Kim, Tae Hyuk Kim, Hee Kyung Kim, Bo Hyun Kim, Hyon-Seung Yi, Eun Sook Kim, Hosu Kim, Young Nam Kim, Eun Heui Kim, Tae Yong Kim, Sun Wook Kim, Ho-Cheol Kang, Jae Hoon Chung, Young Kee Shong, Won Bae Kim
    Endocrinology and Metabolism.2017; 32(4): 434.     CrossRef
  • Clinicopathological Significance of Large Tumor Suppressor (LATS) Expression in Gastric Cancer
    Myoung Won Son, Geum Jong Song, Si-Hyong Jang, Soon Auck Hong, Mee-Hye Oh, Ji-Hye Lee, Moo Jun Baek, Moon Soo Lee
    Journal of Gastric Cancer.2017; 17(4): 363.     CrossRef
  • Thyroid Cancer in Pediatric Age: A Single Institution Experience
    Hyo-Jun Kim, Ji-Won Han, Joong Kee Youn, Hee-Beom Yang, Chaeyoun Oh, Hyun-Young Kim, Sung-Eun Jung, Kwi-Won Park
    Journal of the Korean Association of Pediatric Surgeons.2017; 23(2): 42.     CrossRef
  • Value of imaging study in predicting pelvic lymph node metastases of uterine cervical cancer
    Wonguen Jung, Kyung Ran Park, Kyung-Ja Lee, Kyubo Kim, Jihae Lee, Songmi Jeong, Yi-Jun Kim, Jiyoung Kim, Hai-Jeon Yoon, Byung-Chul Kang, Hae Soo Koo, Sun Hee Sung, Min-Sun Cho, Sanghui Park
    Radiation Oncology Journal.2017; 35(4): 340.     CrossRef
  • The unrealized potential: cohort effects and age-period-cohort analysis
    Jongho Heo, Sun-Young Jeon, Chang-Mo Oh, Jongnam Hwang, Juhwan Oh, Youngtae Cho
    Epidemiology and Health.2017; 39: e2017056.     CrossRef
  • Comparison of bone mineral loss by combined androgen block agonist versus GnRH in patients with prostate cancer: A 12 month-prospective observational study
    Jae Young Joung, Sung Han Kim, Sohee Kim, Koon Ho Rha, Hyeong Gon Kim, Cheol Kwak, Ji Youl Lee, Seong Soo Jeon, Sung Kyu Hong, Hyeon Jeong, Moon Ki Jo, Dalsan You, In Gab Jeong, Jun Hyuk Hong, Choung-Soo Kim
    Scientific Reports.2017;[Epub]     CrossRef
  • Prognostic value of KRAS mutation in advanced non-small-cell lung cancer treated with immune checkpoint inhibitors: A meta-analysis and review
    Jung Han Kim, Hyeong Su Kim, Bum Jun Kim
    Oncotarget.2017; 8(29): 48248.     CrossRef
  • The role of targeted agents in the adjuvant treatment of colon cancer: a meta-analysis of randomized phase III studies and review
    Bum Jun Kim, Jae Ho Jeong, Jung Han Kim, Hyeong Su Kim, Hyun Joo Jang
    Oncotarget.2017; 8(19): 31112.     CrossRef
  • Variations in the bitterness perception-related genes TAS2R38 and CA6 modify the risk for colorectal cancer in Koreans
    Jeong-Hwa Choi, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
    Oncotarget.2017; 8(13): 21253.     CrossRef
  • Detection of somatic variants and EGFR mutations in cell-free DNA from non-small cell lung cancer patients by ultra-deep sequencing using the ion ampliseq cancer hotspot panel and droplet digital polymerase chain reaction
    Jae Sook Sung, Hyon Yong Chong, Nak-Jung Kwon, Hae Mi Kim, Jong Won Lee, Boyeon Kim, Saet Byeol Lee, Chang Won Park, Jung Yoon Choi, Won Jin Chang, Yoon Ji Choi, Sung Yong Lee, Eun Joo Kang, Kyong Hwa Park, Yeul Hong Kim
    Oncotarget.2017; 8(63): 106901.     CrossRef
  • Impact of radiation dose in postoperative radiotherapy after R1 resection for extrahepatic bile duct cancer: long term results from a single institution
    Byoung Hyuck Kim, Eui Kyu Chie, Kyubo Kim, Jin-Young Jang, Sun Whe Kim, Do-Youn Oh, Yung-Jue Bang, Sung W. Ha
    Oncotarget.2017; 8(44): 78076.     CrossRef
  • The Effects of Physical Activity and Body Fat Mass on Colorectal Polyp Recurrence in Patients with Previous Colorectal Cancer
    Jihye Park, Jae Hyun Kim, Hyun Jung Lee, Soo Jung Park, Sung Pil Hong, Jae Hee Cheon, Won Ho Kim, Ji Soo Park, Justin Y. Jeon, Tae Il Kim
    Cancer Prevention Research.2017; 10(8): 478.     CrossRef
  • How do we manage high-grade T1 bladder cancer? Conservative or aggressive therapy?
    Seok Joong Yun, Seon-Kyu Kim, Wun-Jae Kim
    Investigative and Clinical Urology.2016; 57(Suppl 1): S44.     CrossRef
  • Factors Affecting Long Term Survival for Metastatic Gastric Cancer Treated with Chemotherapy
    Seong Kyeong Lim, Kyoungwon Jung, Moo In Park, Jae Hyun Kim, Sung Eun Kim, Won Moon, Seun Ja Park
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2016; 16(2): 97.     CrossRef
  • The clinical utilization of radiation therapy in Korea between 2009 and 2013
    Jin-Kyu Kang, Mi-Sook Kim, Won-Il Jang, Young Seok Seo, Hee Jin Kim, Chul Koo Cho, Hyung Jun Yoo, Eun Kyung Paik, Yu Jin Cha, Hyun Jin Song
    Radiation Oncology Journal.2016; 34(2): 88.     CrossRef
  • Anticancer Effect of Fucoidan on DU-145 Prostate Cancer Cells through Inhibition of PI3K/Akt and MAPK Pathway Expression
    Gang-Sik Choo, Hae-Nim Lee, Seong-Ah Shin, Hyeong-Jin Kim, Ji-Youn Jung
    Marine Drugs.2016; 14(7): 126.     CrossRef
  • The up-regulation of long non-coding RNA CCAT2 indicates a poor prognosis for prostate cancer and promotes metastasis by affecting epithelial-mesenchymal transition
    Jinfeng Zheng, Shaoxiong Zhao, Xiaolong He, Zhili Zheng, Weibin Bai, Youlin Duan, Shanlin Cheng, Juncai Wang, Xucheng Liu, Gang Zhang
    Biochemical and Biophysical Research Communications.2016; 480(4): 508.     CrossRef
  • Tumor-related leukocytosis is associated with poor radiation response and clinical outcome in uterine cervical cancer patients
    Y. Cho, K.H. Kim, H.I. Yoon, G.E. Kim, Y.B. Kim
    Annals of Oncology.2016; 27(11): 2067.     CrossRef
  • Recent Updates on the Management of Medullary Thyroid Carcinoma
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    Endocrinology and Metabolism.2016; 31(3): 392.     CrossRef
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    Journal of Gastric Cancer.2016; 16(3): 182.     CrossRef
  • Korean Gastric Cancer Association Nationwide Survey on Gastric Cancer in 2014

    Journal of Gastric Cancer.2016; 16(3): 131.     CrossRef
  • Development and Validation of the Korean Version of Hand-Foot Skin Reaction and Quality of Life Questionnaire (HF-QoL-K)
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    Journal of Korean Medical Science.2016; 31(12): 1969.     CrossRef
  • Chemotherapy in Advanced Urothelial Carcinoma
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    The Korean Journal of Urological Oncology.2016; 14(2): 47.     CrossRef
  • The challenge of screening for early gastric cancer in China
    Liang Zong, Masanobu Abe, Yasuyuki Seto, Jiafu Ji
    The Lancet.2016; 388(10060): 2606.     CrossRef
  • Migration and invasion of drug-resistant lung adenocarcinoma cells are dependent on mitochondrial activity
    Ji Hoon Jeon, Dong Keon Kim, Youngmi Shin, Hee Yeon Kim, Bomin Song, Eun Young Lee, Jong Kwang Kim, Hye Jin You, Heesun Cheong, Dong Hoon Shin, Seong-Tae Kim, Jae-Ho Cheong, Soo Youl Kim, Hyonchol Jang
    Experimental & Molecular Medicine.2016; 48(12): e277.     CrossRef
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    The Journal of Internal Korean Medicine.2016; 37(5): 776.     CrossRef
  • Examination History and Abnormal Thyroid and Breast Lesions According to Residential Distance from Nuclear Power Plants
    Young-Khi Lim
    Journal of Radiation Protection and Research.2016; 41(4): 402.     CrossRef
  • Expression and clinical significance of defensin alpha 6 in colorectal cancer
    Saengjin Park, Taesung Ahn, Hyunyong Lee, Dong Jun Jeong, Hae Il Jeong, Myoung Won Son, Moon Soo Lee, Moo-Jun Baek
    Korean Journal of Clinical Oncology.2016; 12(2): 78.     CrossRef
  • Clinicopathologic characteristics of patients with sporadic colorectal cancer under the age of 30
    Jong Wook Oh, Jung Wook Huh, Yoon Ah Park, Yong Beom Cho, Seong Hyeon Yun, Woo Yong Lee, Hee Cheol Kim
    Korean Journal of Clinical Oncology.2016; 12(2): 67.     CrossRef
  • Development and Evaluation of an Infection Prevention Self-care Application for Cancer Patients with Chemotherapy
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    Asian Oncology Nursing.2016; 16(4): 197.     CrossRef
  • Effect of Abdominal Skin Massage and Warming Therapy on the Pain and Anxiety in Breast Cancer Patients who Underwent Hormone Injections
    Jin Hee Jun, Youn Ok Lee, Se-Na Lee
    Asian Oncology Nursing.2016; 16(4): 226.     CrossRef
  • Anxiety and Depression as Predictive Factors for Quality of Life in Patients with Advanced Gastrointestinal Cancer
    JungHwa Chung, Jihyun Kwon, Hyun Kyung Kim, Gawon Ju, Seung Taik Kim, Hye Sook Han
    Asian Oncology Nursing.2016; 16(4): 242.     CrossRef
  • Dietary Changes After Breast Cancer Diagnosis: Associations with Physical Activity, Anthropometry, and Health-related Quality of life Among Korean Breast Cancer Survivors
    Sihan Song, Hyun Jo Youn, So-Youn Jung, Eunsook Lee, Zisun Kim, Jihyoung Cho, Young Bum Yoo, Hyeong-Gon Moon, Dong-Young Noh, Jung Eun Lee
    Korean Journal of Community Nutrition.2016; 21(6): 533.     CrossRef
  • Risk Factors of Postoperative Hypocalcemia after Total Thyroidectomy of Papillary Thyroid Carcinoma Patients
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  • Risk Factors of Postoperative Hypocalcemia after Total Thyroidectomy of Papillary Thyroid Carcinoma Patients
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Close layer
Prediction of Cancer Incidence and Mortality in Korea, 2016
Kyu-Won Jung, Young-Joo Won, Chang-Mo Oh, Hyun-Joo Kong, Hyunsoon Cho, Jong-Keun Lee, Duk Hyoung Lee, Kang Hyun Lee
Cancer Res Treat. 2016;48(2):451-457.   Published online March 25, 2016
DOI: https://doi.org/10.4143/crt.2016.092
AbstractAbstract PDFPubReaderePub
Purpose
To estimate of Korea’s current cancer burden, this study aimed to report on projected cancer incidence and mortality rates for the year 2016.
Materials and Methods
Cancer incidence data from 1999 to 2013 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2014 were acquired from Statistics Korea. Cancer incidence in 2016 was projected by fitting a linear regression model to observed age-specific cancer incidence rates against observed years, then multiplying the projected age-specific rates by the age-specific population. The Joinpoint regression model was used to determine at which year the linear trend changed significantly.
Results
A total of 254,962 new cancer cases and 75,172 cancer deaths are expected to occur in Korea in 2016. The five leading primary cancer incident sites in 2016 were estimated colorectal, stomach, lung, liver and thyroid cancer in men; thyroid, breast, colorectal, stomach, and lung cancer in women.
Conclusion
Currently cancer is one of the foremost public health concerns in Korea. Although cancer rates are anticipated to decrease the nation’s cancer burden will continue to increase as the population ages.

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  • Pre-transplant Dementia is Associated with Poor Survival After Hematopoietic Stem Cell Transplantation: A Nationwide Cohort Study with Propensity Score Matched Control
    Sheng-Min Wang, Sung-Soo Park, See Hyun Park, Nak-Young Kim, Dong Woo Kang, Hae-Ran Na, Young-Yi Bae, Jong Wook Lee, Seunghoon Han, Hyun Kook Lim
    Clinical Psychopharmacology and Neuroscience.2021; 19(2): 294.     CrossRef
  • Improving the Subtype Classification of Non-small Cell Lung Cancer by Elastic Deformation Based Machine Learning
    Yang Gao, Fan Song, Peng Zhang, Jian Liu, Jingjing Cui, Yingying Ma, Guanglei Zhang, Jianwen Luo
    Journal of Digital Imaging.2021; 34(3): 605.     CrossRef
  • Can natural killer cell activity help screen patients requiring a biopsy for the diagnosis of prostate cancer?
    Bum Sik Tae, Byeong Jo Jeon, Young Hoon Lee, Hoon Choi, Jae Young Park, Jae Hyun Bae
    International braz j urol.2020; 46(2): 244.     CrossRef
  • Adolescent overweight and obesity and the risk of papillary thyroid cancer in adulthood: a large-scale case-control study
    Kyoung-Nam Kim, Yunji Hwang, Kyu Hyung Kim, Kyu Eun Lee, Young Joo Park, Su-jin Kim, Hyungju Kwon, Do Joon Park, BeLong Cho, Ho-Chun Choi, Daehee Kang, Sue K. Park
    Scientific Reports.2020;[Epub]     CrossRef
  • Factors Influencing Quality of Life Among Breast Cancer Patients Following Immediate Breast Reconstruction
    A Young Kim, Jeong Hye Kim
    Asian Oncology Nursing.2020; 20(1): 1.     CrossRef
  • Association between De Ritis ratio (aspartate aminotransferase/alanine aminotransferase) and oncological outcomes in bladder cancer patients after radical cystectomy
    Yun-Sok Ha, Sang Won Kim, So Young Chun, Jae-Wook Chung, Seock Hwan Choi, Jun Nyung Lee, Bum Soo Kim, Hyun Tae Kim, Eun Sang Yoo, Tae Gyun Kwon, Won Tae Kim, Wun-Jae Kim, Tae-Hwan Kim
    BMC Urology.2019;[Epub]     CrossRef
  • Epigenetic inactivation of HOXD10 is associated with human colon cancer via inhibiting the RHOC/AKT/MAPK signaling pathway
    Yu-hong Yuan, Han-yu Wang, Yu Lai, Wa Zhong, Wei-ling Liang, Fu-de Yan, Zhong Yu, Jun-kai Chen, Ying Lin
    Cell Communication and Signaling.2019;[Epub]     CrossRef
  • Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2016
    Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Eun Sook Lee
    Cancer Research and Treatment.2019; 51(2): 417.     CrossRef
  • Is androgen deprivation therapy associated with cerebral infarction in patients with prostate cancer? A Korean nationwide population‐based propensity score matching study
    Bum Sik Tae, Byeong Jo Jeon, Hoon Choi, Jae Hyun Bae, Jae Young Park
    Cancer Medicine.2019; 8(9): 4475.     CrossRef
  • Robotic Thyroidectomy Decreases Postoperative Pain Compared With Conventional Thyroidectomy
    Min Kyoung Kim, Hyun Kang, Geun Joo Choi, Kyung Ho Kang
    Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2019; 29(4): 255.     CrossRef
  • Are shape morphologies associated with survival? A potential shape-based biomarker predicting survival in lung cancer
    Maliazurina Saad, Ik Hyun Lee, Tae-Sun Choi
    Journal of Cancer Research and Clinical Oncology.2019; 145(12): 2937.     CrossRef
  • The effects of BRCA1 expression on the chemosensitivity of gastric cancer cells to platinum agents
    Geon Kim, Jisu Kim, Su‑Young Han, In Hwang, Hee Kim, Hyeyoung Min
    Oncology Letters.2019;[Epub]     CrossRef
  • Clinical significance of overexpression of NRG1 and its receptors, HER3 and HER4, in gastric cancer patients
    Sumi Yun, Jiwon Koh, Soo Kyung Nam, Jung Ok Park, Sung Mi Lee, Kyoungyul Lee, Kyu Sang Lee, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Gheeyoung Choe, Woo Ho Kim, Hye Seung Lee
    Gastric Cancer.2018; 21(2): 225.     CrossRef
  • Complete cure of advanced hepatocellular carcinoma with right adrenal gland metastasis and portal vein thrombosis by multiple applications of an interdisciplinary therapy: case report with 8-year follow up
    Hojung Jung, Byung Ik Kim, Yong Kyun Cho, Woo Kyu Jeon, Hong Joo Kim, Hyun Pyo Hong
    Clinical and Molecular Hepatology.2018; 24(4): 424.     CrossRef
  • Epidemiology of Intracranial Metastases in Korea: A National Cohort Investigation
    Tackeun Kim, Changhoon Song, Jung Ho Han, In-Ah Kim, Yu Jung Kim, Se Hyun Kim, Jee Hyun Kim, Chae-Yong Kim
    Cancer Research and Treatment.2018; 50(1): 164.     CrossRef
  • Trend Analysis for the Choice and Cost of Lung Cancer Treatment in South Korea, 2003-2013
    Dohun Kim, So Young Kim, Beomseok Suh, Jong Hyock Park
    Cancer Research and Treatment.2018; 50(3): 757.     CrossRef
  • Androgen receptor as a prognostic biomarker and therapeutic target in uterine leiomyosarcoma
    Min-Hyun Baek, Jeong-Yeol Park, Yangsoon Park, Kyu-Rae Kim, Dae-Yeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
    Journal of Gynecologic Oncology.2018;[Epub]     CrossRef
  • Second primary colorectal cancer among endometrial cancer survivor: shared etiology and treatment sequelae
    Myong Cheol Lim, Young-Joo Won, Jiwon Lim, Sang-Soo Seo, Sokbom Kang, Chong Woo Yoo, Joo-Young Kim, Jae Hwan Oh, Robert E. Bristow, Sang-Yoon Park
    Journal of Cancer Research and Clinical Oncology.2018; 144(5): 845.     CrossRef
  • Efficacy of a clinical pathway for patients with thyroid cancer
    Hyungju Kwon, Joon‐Hyop Lee, Joohyun Woo, Woosung Lim, Byung‐In Moon, Nam Sun Paik
    Head & Neck.2018; 40(9): 1909.     CrossRef
  • Molecular Screening of Small Biopsy Samples Using Next-Generation Sequencing in Korean Patients with Advanced Non-small Cell Lung Cancer: Korean Lung Cancer Consortium (KLCC-13-01)
    Bo Mi Ku, Mi Hwa Heo, Joo-Hang Kim, Byoung Chul Cho, Eun Kyung Cho, Young Joo Min, Ki Hyeong Lee, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Tae Jung Kim, Ho Yun Lee, Hojoong Kim, Kyung-Jong Lee, Myung-Ju Ahn
    Journal of Pathology and Translational Medicine.2018; 52(3): 148.     CrossRef
  • Lung Cancer Screening with Low-Dose CT in Female Never Smokers: Retrospective Cohort Study with Long-term National Data Follow-up
    Hyae Young Kim, Kyu-Won Jung, Kun Young Lim, Soo-Hyun Lee, Jae Kwan Jun, Jeongseon Kim, Bin Hwangbo, Jin Soo Lee
    Cancer Research and Treatment.2018; 50(3): 748.     CrossRef
  • Treatment efficacy between total thyroidectomy and lobectomy for patients with papillary thyroid microcarcinoma: A systemic review and meta-analysis
    Wuping Zheng, Jingtai Li, Pengfei Lv, Zhilin Chen, Pingming Fan
    European Journal of Surgical Oncology.2018; 44(11): 1679.     CrossRef
  • Impact of hospital care volume on clinical outcomes of laparoscopic radical hysterectomy for cervical cancer
    Banghyun Lee, Kidong Kim, Youngmi Park, Myong Cheol Lim, Robert E. Bristow
    Medicine.2018; 97(49): e13445.     CrossRef
  • Relationship of Prostate-Specific Antigen Level With Obesity Indices in Korean Middle-Aged Population
    Seung Ki Min, Kwibok Choi, Byoung Hoon Kim, In-Chang Cho
    The Korean Journal of Urological Oncology.2018; 16(3): 103.     CrossRef
  • Clinical significance of incidentally detected bladder wall thickening on computed tomography
    Wan Song, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Han Yong Choi, Hyun Moo Lee
    International Urology and Nephrology.2017; 49(2): 191.     CrossRef
  • The association between artificial light at night and prostate cancer in Gwangju City and South Jeolla Province of South Korea
    Ka Young Kim, Eunil Lee, Yun Jeong Kim, Jinsun Kim
    Chronobiology International.2017; 34(2): 203.     CrossRef
  • Use of a Combined Gene Expression Profile in Implementing a Drug Sensitivity Predictive Model for Breast Cancer
    Xianglan Zhang, In-Ho Cha, Ki-Yeol Kim
    Cancer Research and Treatment.2017; 49(1): 116.     CrossRef
  • Efficacy of fluoropyrimidine-based chemotherapy in patients with advanced biliary tract cancer after failure of gemcitabine plus cisplatin: retrospective analysis of 321 patients
    Bum Jun Kim, Changhoon Yoo, Kyu-pyo Kim, Jaewon Hyung, Seong Joon Park, Baek-Yeol Ryoo, Heung-Moon Chang
    British Journal of Cancer.2017; 116(5): 561.     CrossRef
  • Role of adjuvant radiotherapy for localized extrahepatic bile duct cancer
    Yi-Jun Kim, Kyubo Kim, Seog Ki Min, Eun Mi Nam
    The British Journal of Radiology.2017;[Epub]     CrossRef
  • Molecular Testing for Gastrointestinal Cancer
    Hye Seung Lee, Woo Ho Kim, Yoonjin Kwak, Jiwon Koh, Jeong Mo Bae, Kyoung-Mee Kim, Mee Soo Chang, Hye Seung Han, Joon Mee Kim, Hwal Woong Kim, Hee Kyung Chang, Young Hee Choi, Ji Y. Park, Mi Jin Gu, Min Jin Lhee, Jung Yeon Kim, Hee Sung Kim, Mee-Yon Cho
    Journal of Pathology and Translational Medicine.2017; 51(2): 103.     CrossRef
  • Endoscopic Thyroidectomy Via the Cervico-axillary Approach for Thyroid Cancer: Initial Experience in a Single Institute
    Jeong Shin An, Hyun Goo Kim, Se Hyun Paek, Jun Woo Lee, Juhyun Woo, Hyungju Kwon, Woosung Lim, Byung-In Moon, Nam Sun Paik
    Korean Journal of Endocrine Surgery.2017; 17(1): 19.     CrossRef
  • Endoscopic Thyroidectomy Via the Cervico-axillary Approach for Thyroid Cancer: Initial Experience in a Single Institute
    Jeong Shin An, Hyun Goo Kim, Se Hyun Paek, Jun Woo Lee, Juhyun Woo, Hyungju Kwon, Woosung Lim, Byung-In Moon, Nam Sun Paik
    Korean Journal of Endocrine Surgery.2017; 17(1): 19.     CrossRef
  • The Effect of Post-operative Exercise in Colorectal Cancer Patients: A Pilot Randomized Controlled Trial (RCT) Study
    Ji-hee Min, Ki-yong Ahn, Hyuna Park, Wonhee Cho, Hye Jeong Jung, Nam Kyu Kim, Justin Y Jeon
    Asian Oncology Nursing.2017; 17(1): 29.     CrossRef
  • Survival outcomes after extensive cytoreductive surgery and selective neoadjuvant chemotherapy according to institutional criteria in bulky stage IIIC and IV epithelial ovarian cancer
    Myong Cheol Lim, Heong Jong Yoo, Yong Jung Song, Sang-Soo Seo, Sokbom Kang, Sun Ho Kim, Chong Woo Yoo, Sang-Yoon Park
    Journal of Gynecologic Oncology.2017;[Epub]     CrossRef
  • Malignancies in Korean patients with immunoglobulin G4‐related disease
    Sung Soo Ahn, Jason Jungsik Song, Yong‐Beom Park, Sang‐Won Lee
    International Journal of Rheumatic Diseases.2017; 20(8): 1028.     CrossRef
  • Do hepatic-sided tumors require more extensive resection than peritoneal-sided tumors in patients with T2 gallbladder cancer? Results of a retrospective multicenter study
    Woohyung Lee, Chi-Young Jeong, Jae Yool Jang, Young Hoon Kim, Young Hoon Roh, Kwan Woo Kim, Sung Hwa Kang, Myung Hee Yoon, Hyung Il Seo, Sung Pil Yun, Jeong-Ik Park, Bo-Hyun Jung, Dong Hoon Shin, Young Il Choi, Hyung Hwan Moon, Chong Woo Chu, Je Ho Ryu, K
    Surgery.2017; 162(3): 515.     CrossRef
  • The prognostic value of BAP1, PBRM1, pS6, PTEN, TGase2, PD-L1, CA9, PSMA, and Ki-67 tissue markers in localized renal cell carcinoma: A retrospective study of tissue microarrays using immunohistochemistry
    Sung Han Kim, Weon Seo Park, Eun Young Park, Boram Park, Jungnam Joo, Jae Young Joung, Ho Kyung Seo, Kang Hyun Lee, Jinsoo Chung, Jung Weon Lee
    PLOS ONE.2017; 12(6): e0179610.     CrossRef
  • Differential proteome expression analysis of androgen-dependent and -independent pathways in LNCaP prostate cancer cells
    Seho Cha, Dong Hoon Shin, Jun Ryeong Seok, Jae Kyung Myung
    Experimental Cell Research.2017; 359(1): 215.     CrossRef
  • Cholecystectomy can increase the risk of colorectal cancer: A meta-analysis of 10 cohort studies
    Yong Zhang, Hao Liu, Li Li, Min Ai, Zheng Gong, Yong He, Yunlong Dong, Shuanglan Xu, Jun Wang, Bo Jin, Jianping Liu, Zhaowei Teng, Nathan A. Ellis
    PLOS ONE.2017; 12(8): e0181852.     CrossRef
  • Estimated future incidence of malignant mesothelioma in South Korea: Projection from 2014 to 2033
    Kyeong Min Kwak, Domyung Paek, Seung-sik Hwang, Young-Su Ju, Mark Allen Pershouse
    PLOS ONE.2017; 12(8): e0183404.     CrossRef
  • A pilot study identifying a potential plasma biomarker for determining EGFR mutations in exons 19 or 21 in lung cancer patients
    Aryo D. Pamungkas, Carl A. Medriano, Eunjung Sim, Sungyong Lee, Youngja H. Park
    Molecular Medicine Reports.2017; 15(6): 4155.     CrossRef
  • Incidence and mortality of kidney cancer: temporal patterns and global trends in 39 countries
    Martin C. S. Wong, William B. Goggins, Benjamin H. K. Yip, Franklin D. H. Fung, Colette Leung, Yuan Fang, Samuel Y. S. Wong, C. F. Ng
    Scientific Reports.2017;[Epub]     CrossRef
  • Exercise Perception during Hematopoietic Transplantation for Hematological Cancer Patients
    Mi-seong Yu, Ji Yong Byeon, Ki-Yong An, Meeok Choi, June-Won Cheong, Justin Y. Jeon
    The Korean Journal of Physical Education.2017; 56(6): 527.     CrossRef
  • Telomere length is correlated with mitochondrial DNA copy number in intestinal, but not diffuse, gastric cancer
    Soo-Jung Jung, Ji-Hyoung Cho, Won-Jin Park, Yu-Ran Heo, Jae-Ho Lee
    Oncology Letters.2017; 14(1): 925.     CrossRef
  • Diabetes Mellitus Increases the Risk of Intrahepatic Recurrence of Hepatocellular Carcinoma after Surgical Resection
    Yunseon Choi, YoungKil Choi, Chang Soo Choi, Yun-Han Lee
    Tumori Journal.2017; 103(3): 279.     CrossRef
  • Prognostic impact offibroblast growth factor receptor 2gene amplification in patients receiving fluoropyrimidine and platinum chemotherapy for metastatic and locally advanced unresectable gastric cancers
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    Oncotarget.2017; 8(20): 33844.     CrossRef
  • Programmed death ligand-1 and MET co-expression is a poor prognostic factor in gastric cancers after resection
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    Oncotarget.2017; 8(47): 82399.     CrossRef
  • Risk factors for feelings of sadness and suicide attempts among cancer survivors in South Korea: findings from nationwide cross-sectional study (KNHANES IV–VI)
    Jeewoong Choi, Mijo Lee, Myung Ki, Ju-Yeong Lee, Yeong-Jun Song, Miram Kim, Sunyoung Lee, Soonjoo Park, Jiseun Lim
    BMJ Open.2017; 7(12): e016130.     CrossRef
  • Bacillusspp. orBacillusspp.-Derived Membrane Vesicles Induce the Intrinsic Pathways of Apoptosis of Human Colon Cancer Cell Lines
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  • Anti-proliferation Effect of Coscinoderma sp. Extract on Human Colon Cancer Cells
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    Journal of Food Hygiene and Safety.2016; 31(4): 294.     CrossRef
  • Pregnancy-Associated Risk Factors of Postpartum Breast Cancer in Korea: A Nationwide Health Insurance Database Study
    Eun Joo Kang, Jae Hong Seo, Log Young Kim, Geun U. Park, Min-Jeong Oh, Pyoung-Jae Park, Geum Joon Cho, Pal Bela Szecsi
    PLOS ONE.2016; 11(12): e0168469.     CrossRef
  • The Correlation of Tissue-Based Biomarkers in Primary and Metastatic Renal Cell Carcinoma Lesions: A Tissue Microarray Study
    Sung Han Kim, Weon Seo Park, Eun Young Park, Boram Park, Jungnam Joo, Jae Young Joung, Ho Kyung Seo, Kang Hyun Lee, Jinsoo Chung
    The Korean Journal of Urological Oncology.2016; 14(3): 152.     CrossRef
  • Interleukin-10 Polymorphisms in Association with Prognosis in Patients with B-Cell Lymphoma Treated by R-CHOP
    Min Kyeong Kim, Kyong-Ah Yoon, Eun Young Park, Jungnam Joo, Eun Young Lee, Hyeon-Seok Eom, Sun-Young Kong
    Genomics & Informatics.2016; 14(4): 205.     CrossRef
  • Anxiety and Depression as Predictive Factors for Quality of Life in Patients with Advanced Gastrointestinal Cancer
    JungHwa Chung, Jihyun Kwon, Hyun Kyung Kim, Gawon Ju, Seung Taik Kim, Hye Sook Han
    Asian Oncology Nursing.2016; 16(4): 242.     CrossRef
  • 16,424 View
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Tolerability and Outcomes of First-Line Pemetrexed-Cisplatin Followed by Gefitinib Maintenance Therapy Versus Gefitinib Monotherapy in Korean Patients with Advanced Nonsquamous Non-small Cell Lung Cancer: A Post Hoc Descriptive Subgroup Analysis of a Randomized, Phase 3 Trial
Jin Hyoung Kang, Myung-Ju Ahn, Dong-Wan Kim, Eun Kyung Cho, Joo-Hang Kim, Sang Won Shin, Xin Wang, Jong Seok Kim, Mauro Orlando, Keunchil Park
Cancer Res Treat. 2016;48(2):458-464.   Published online October 14, 2015
DOI: https://doi.org/10.4143/crt.2015.135
AbstractAbstract PDFPubReaderePub
Purpose
We recently reported on a randomized, open-label, phase 3 trial comparing pemetrexed-cisplatin chemotherapy followed by gefitinib maintenance therapy (PC/G) with gefitinib monotherapy in patients with non-small cell lung cancer (NSCLC). Here, we report on a post hoc subgroup analysis of that study assessing the demographics and disposition of the Korean patient subgroup, and comparing the tolerability of PC/G and gefitinib monotherapy and the tumor response with respect to epidermal growth factor receptor (EGFR) status.
Materials and Methods
Patients, who were ≥ 18 years, chemonaïve, Korean, light ex-smokers/never-smokers with advanced NSCLC, were randomly assigned (1:1) to PC/G or gefitinib monotherapy. Treatment-emergent adverse events (TEAEs) were graded, and tumor response was measured as change in lesion sum from baseline at best response. The study was registered with ClinicalTrials. gov, NCT01017874.
Results
Overall, 111 Korean patients were treated (PC/G, 51; gefitinib, 60). Between-arm characteristics were balanced and similar to those of the overall population. Treatment discontinuations due to adverse events were low (PC/G: 1, 2.0%; gefitinib: 7, 11.7%). Overall, 92 patients (82.9%) reported ≥ 1 TEAE (PC/G, 44; gefitinib, 48); few patients (PC/G, 16; gefitinib, 7) reported severe TEAEs; the most frequent was neutropenia (PC/G arm) and elevated alanine aminotransferase (gefitinib arm). The lesion sum was decreased by PC/G treatment in most patients, regardless of EGFRmutation status, while gefitinib monotherapy reduced the lesion sum in EGFR-positive patients but had no effect in EGFR-negative patients.
Conclusion
Our results confirm that both PC/G and gefitinib were well tolerated in Korean patients, regardless of EGFR status; however, patients with EGFR wild-type NSCLC may not benefit from gefitinib monotherapy.

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  • Gefitinib for advanced non-small cell lung cancer
    Esther HA Sim, Ian A Yang, Richard Wood-Baker, Rayleen V Bowman, Kwun M Fong
    Cochrane Database of Systematic Reviews.2018;[Epub]     CrossRef
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Original Articles
A Phase II Study of Weekly Paclitaxel Plus Gemcitabine as a Second-Line Therapy in Patients with Metastatic or Recurrent Small Cell Lung Cancer
Tak Yun, Heung Tae Kim, Ji-Youn Han, Sung Jin Yoon, Hyae Young Kim, Byung-Ho Nam, Jin Soo Lee
Cancer Res Treat. 2016;48(2):465-472.   Published online May 26, 2015
DOI: https://doi.org/10.4143/crt.2015.061
AbstractAbstract PDFPubReaderePub
Purpose
Paclitaxel (P) and gemcitabine (G) are clinically synergistic in small cell lung cancer (SCLC). We evaluated the efficacy of PG as a salvage treatment for SCLC patients whose disease progressed after a platinum-containing regimen.
Materials and Methods
Eligibility included histologically confirmed SCLC, one dimensionally measurable disease, Eastern Cooperative Oncology Group performance status 0-2, and progressive disease after platinum-based chemotherapy. Treatment consisted of P (80 mg/m2) and G (1,000 mg/m2) on days 1 and 8 of each cycle of 21 days until disease progression.
Results
Thirty-three patients seen between December 2005 and February 2009 were selected into this study. Thirty patients (91%) had received irinotecan-platinum, and three had received etoposide-platinum. Sixteen patients (49%) had a treatment-free interval of less than 3 months. The overall response rate was 30.3% (29.4% in sensitive relapse and 31.3% in refractory relapse). The median time to progression was 12.0 weeks and median overall survival (OS) 31.0 weeks, with a 1-year OS rate of 30.3%. Toxicities were moderate and manageable with 18.2% grade (G) 4 neutropenia, 24.2% G3 thrombocytopenia, 6.1% G3 sensory neuropathy, and 3% G3 asthenia. One patient developed febrile neutropenia.
Conclusion
Second-line paclitaxel and gemcitabine were well-tolerated and moderately active in SCLC patients previously treated with platinum-based chemotherapy.

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  • Overcoming multi-drug resistance in SCLC: a synergistic approach with venetoclax and hydroxychloroquine targeting the lncRNA LYPLAL1-DT/BCL2/BECN1 pathway
    Shuxin Li, Jianyi Lv, Zhihui Li, Qiuyu Zhang, Jing Lu, Xueyun Huo, Meng Guo, Xin Liu, Changlong Li, Jinghui Wang, Hanping Shi, Li Deng, Zhenwen Chen, Xiaoyan Du
    Molecular Cancer.2024;[Epub]     CrossRef
  • Impact of Nab-Paclitaxel Plus PD-1/PD-L1 Inhibitor on Chemorefractory Relapsed Small-Cell Lung Cancer
    Fengchun Mu, Bingjie Fan, Haoqian Li, Wenru Qin, Chunni Wang, Bing Zou, Linlin Wang
    Future Oncology.2023; 19(19): 1367.     CrossRef
  • Iron oxide nanoparticles induce ferroptosis via the autophagic pathway by synergistic bundling with paclitaxel
    Qi Nie, Wenqing Chen, Tianmei Zhang, Shangrong Ye, Zhongyu Ren, Peng Zhang, Jian Wen
    Molecular Medicine Reports.2023;[Epub]     CrossRef
  • Current Strategies for Extensive Stage Small Cell Lung Cancer Beyond First-line Therapy
    Zhonglin Hao, Janeesh Sekkath Veedu
    Clinical Lung Cancer.2022; 23(1): 14.     CrossRef
  • Clinical predictors of survival in patients with relapsed/refractory small-cell lung cancer treated with checkpoint inhibitors: a German multicentric real-world analysis
    Jan A. Stratmann, Radha Timalsina, Akin Atmaca, Vivian Rosery, Nikolaj Frost, Jürgen Alt, Cornelius F. Waller, Niels Reinmuth, Gernot Rohde, Felix C. Saalfeld, Aaron Becker von Rose, Fabian Acker, Lukas Aspacher, Miriam Möller, Martin Sebastian
    Therapeutic Advances in Medical Oncology.2022;[Epub]     CrossRef
  • Functionalized FcRn-targeted nanosystems for oral drug delivery: A new approach to colorectal cancer treatment
    Fatima Hameedat, Nuria A. Pizarroso, Natália Teixeira, Soraia Pinto, Bruno Sarmento
    European Journal of Pharmaceutical Sciences.2022; 176: 106259.     CrossRef
  • Comparison of two regimens of weekly paclitaxel plus gemcitabine in patients with metastatic breast cancer: propensity score–matched analysis of real-world data
    Chengcheng Gong, Yizhao Xie, Yannan Zhao, Yi Li, Jian Zhang, Leiping Wang, Jun Cao, Zhonghua Tao, Xichun Hu, Biyun Wang
    Therapeutic Advances in Drug Safety.2022;[Epub]     CrossRef
  • Impact of Nab-Paclitaxel Plus PD-1/PD-L1 Inhibitor Versus Traditional Chemotherapy for Retreatment Small Cell Lung Cancer Patients
    Fengchun Mu, Bingjie Fan, Wenru Qin, Shijiang Wang, Bing Zou, Linlin Wang
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • FcRn expression in cancer: Mechanistic basis and therapeutic opportunities
    Imke Rudnik-Jansen, Kenneth A. Howard
    Journal of Controlled Release.2021; 337: 248.     CrossRef
  • Nanoparticle Albumin Bound Paclitaxel in the Third-Line Treatment of Recurrent Small Cell Lung Cancer in Real-World Practice: A Single Center Experience
    Yuchao Wang, Li Li, Chunhua Xu
    Technology in Cancer Research & Treatment.2021;[Epub]     CrossRef
  • Combination therapy with carboplatin and paclitaxel for small cell lung cancer
    Atsuto Mouri, Ou Yamaguchi, Sachiko Miyauchi, Ayako Shiono, Harue Utsugi, Fuyumi Nishihara, Yoshitake Murayama, Hiroshi Kagamu, Kunihiko Kobayashi
    Respiratory Investigation.2019; 57(1): 34.     CrossRef
  • Response to and toxicity of gemcitabine for recurrent ovarian cancer according to number of previous chemotherapy regimens
    Yuji Takei, Yoshifumi Takahashi, Shizuo Machida, Akiyo Taneichi, Suzuyo Takahashi, Tomomi Nagashima, Hiroyuki Morisawa, Yasushi Saga, Shigeki Matsubara, Hiroyuki Fujiwara
    Journal of Obstetrics and Gynaecology Research.2017; 43(2): 358.     CrossRef
  • Second-line treatments of small-cell lung cancers
    Nathalie Baize, Isabelle Monnet, Laurent Greillier, Gilles Quere, Mallorie Kerjouan, Henri Janicot, Alain Vergnenegre, Jean Bernard Auliac, Christos Chouaid
    Expert Review of Anticancer Therapy.2017; 17(11): 1033.     CrossRef
  • 12,664 View
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  • 12 Web of Science
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Overexpression of SOX2 Is Associated with Better Overall Survival in Squamous Cell Lung Cancer Patients Treated with Adjuvant Radiotherapy
Hong In Yoon, Kyu Hyun Park, Eun-Jung Lee, Ki Chang Keum, Chang Geol Lee, Chul Hoon Kim, Yong Bae Kim
Cancer Res Treat. 2016;48(2):473-482.   Published online August 12, 2015
DOI: https://doi.org/10.4143/crt.2015.116
AbstractAbstract PDFPubReaderePub
Purpose
The purpose of this study is to investigate the prognostic significance of SOX2 gene amplification and expression in patients with American Joint Committee on Cancer stage III lung squamous cell carcinoma (SCC) who underwent surgery followed by adjuvant radiotherapy.
Materials and Methods
Pathological specimens were obtained from 33 patients with stage III lung SCC treated with surgery followed by adjuvant radiotherapy between 1996 and 2008. SOX2 gene amplification and protein expression were analyzed using fluorescent in situ hybridization and immunohistochemistry, respectively. Patients were divided into two groups according to their SOX2 gene amplification and protein expression status. Kaplan-Meier estimates and a Cox proportional hazards model were used to identify the prognostic factors affecting patient survival.
Results
The median follow-up period for surviving patientswas 58 months (range, 5 to 102 months). SOX2 gene amplification was observed in 22 patients and protein overexpression in 26 patients. SOX2 overexpression showed significant association with SOX2 gene amplification (p=0.002). In multivariate analysis, SOX2 overexpression was a significant prognostic factor for overall survival (OS) (hazard ratios [HR], 0.1; 95% confidence interval [CI], 0.002 to 0.5; p=0.005) and disease-free survival (DFS) (HR, 0.15; 95% CI, 0.04 to 0.65; p=0.01). Age (HR, 0.33; 95% CI, 0.11 to 0.98; p=0.046) and total radiation dose (HR, 0.13; 95% CI, 0.02 to 0.7; p=0.02) were the independent prognostic factors for OS and DFS. Patients with SOX2 amplification did not show a longer OS (p=0.95) and DFS (p=0.48).
Conclusion
Our data suggested that SOX2 overexpression could be used as a positive prognostic factor in patients with stage III lung SCC receiving adjuvant radiotherapy.

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  • Identifying the key hub genes linked with lung squamous cell carcinoma by examining the differentially expressed and survival genes
    Anushka Pravin Chawhan, Norine Dsouza
    Molecular Genetics and Genomics.2024;[Epub]     CrossRef
  • Gene‐level dissection of chromosome 3q locus amplification in squamous cell carcinoma of the lung using the nCounter assay
    Taesung Jeon, Uk Jeen Oh, Jaeyoung Min, Chungyeul Kim
    Thoracic Cancer.2023; 14(26): 2635.     CrossRef
  • The role of SOX family members in solid tumours and metastasis
    Daniela Grimm, Johann Bauer, Petra Wise, Marcus Krüger, Ulf Simonsen, Markus Wehland, Manfred Infanger, Thomas J. Corydon
    Seminars in Cancer Biology.2020; 67: 122.     CrossRef
  • Blood-Based SOX2-Promoter Methylation in Relation to Exercise and PM2.5 Exposure among Taiwanese Adults
    Chun-Lang Su, Disline Manli Tantoh, Ying-Hsiang Chou, Lee Wang, Chien-Chang Ho, Pei-Hsin Chen, Kuan-Jung Lee, Oswald Ndi Nfor, Shu-Yi Hsu, Wen-Miin Liang, Yung-Po Liaw
    Cancers.2020; 12(2): 504.     CrossRef
  • Epithelial-Mesenchymal Transition in Skin Cancers: A Review
    Anastasia Hodorogea, Andreea Calinescu, Mihaela Antohe, Mihaela Balaban, Roxana Ioana Nedelcu, Gabriela Turcu, Daniela Adriana Ion, Ioana Anca Badarau, Catalin Mihai Popescu, Raluca Popescu, Cristiana Popp, Mirela Cioplea, Luciana Nichita, Ionela Hulea, A
    Analytical Cellular Pathology.2019; 2019: 1.     CrossRef
  • Towards understanding the mechanisms of actions of carcinoembryonic antigen‐related cell adhesion molecule 6 in cancer progression
    Balsam Rizeq, Zain Zakaria, Allal Ouhtit
    Cancer Science.2018; 109(1): 33.     CrossRef
  • Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells
    Ugo Testa, Germana Castelli, Elvira Pelosi
    Cancers.2018; 10(8): 248.     CrossRef
  • SOX2 knockdown inhibits the migration and invasion of basal cell carcinoma cells by targeting the SRPK1‑mediated PI3K/AKT signaling pathway
    Zhuo‑Ran Li, Yong Jiang, Jian‑Zhong Hu, Yang Chen, Quan‑Zhong Liu
    Oncology Letters.2018;[Epub]     CrossRef
  • Association of SOX2 and Nestin DNA amplification and protein expression with clinical features and overall survival in non-small cell lung cancer: A systematic review and meta-analysis
    Qingbao Li, Fang Liu, Yuan Zhang, Lei Fu, Cong Wang, Xuan Chen, Shanghui Guan, Xiangjiao Meng
    Oncotarget.2016; 7(23): 34520.     CrossRef
  • 11,752 View
  • 111 Download
  • 11 Web of Science
  • 9 Crossref
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Effect of Time Interval between Breast-Conserving Surgery and Radiation Therapy on Outcomes of Node-Positive Breast Cancer Patients Treated with Adjuvant Doxorubicin/Cyclophosphamide Followed by Taxane
Hyeon Kang Koh, Kyung Hwan Shin, Kyubo Kim, Eun Sook Lee, In Hae Park, Keun Seok Lee, Jungsil Ro, So-Youn Jung, Seeyoun Lee, Seok Won Kim, Han-Sung Kang, Eui Kyu Chie, Wonshik Han, Dong-Young Noh, Kyung-Hun Lee, Seock-Ah Im, Sung Whan Ha
Cancer Res Treat. 2016;48(2):483-490.   Published online June 5, 2015
DOI: https://doi.org/10.4143/crt.2015.111
AbstractAbstract PDFPubReaderePub
Purpose
This study evaluated the effect of surgery-radiotherapy interval (SRI) on outcomes in patients treated with adjuvant radiotherapy (RT) after breast-conserving surgery (BCS) and adjuvant four cycles of doxorubicin/cyclophosphamide (AC) followed by four cycles of taxane. Materials and Methods From 1999 to 2007, 397 eligible patients were diagnosed. The effect of SRI on outcomes was analyzed using a Cox proportional hazards model, and a maximal chi-square method was used to identify optimal cut-off value of SRI for each outcome.
Results
The median SRI was 6.7 months (range, 5.6 to 10.3 months). A SRI of 7 months was the significant cut-off value for distant metastasis-free survival (DMFS) and disease-free survival (DFS) using a maximal chi-square method. For overall survival, a significant cut-off value was not found. The patients with SRI > 7 months had worse 6-year DMFS and DFS than those with SRI ≤ 7 months on univariate analysis (DMFS, 81% vs. 91%, p=0.003; DFS, 78% vs. 89%, p=0.002). On multivariate analysis, SRI > 7 months did not affect DMFS and DFS. Conclusion RT delayed for more than 7 months after BCS and adjuvant four cycles of AC followed by four cycles of taxane did not compromise clinical outcomes.

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  • MiR-210 regulates lung adenocarcinoma by targeting HIF-1α
    Guolei Cao, Peiwen Fan, Ronghui Ma, Qinghe Wang, Lili He, Haiwen Niu, Qin Luo
    Heliyon.2023; 9(5): e16079.     CrossRef
  • Timing of postmastectomy radiotherapy following adjuvant chemotherapy for high-risk breast cancer: A post hoc analysis of a randomised controlled clinical trial
    Si-Ye Chen, Guang-Yi Sun, Yu Tang, Hao Jing, Yong-Wen Song, Jing Jin, Yue-Ping Liu, Xu-Ran Zhao, Yu-Chun Song, Bo Chen, Shu-Nan Qi, Yuan Tang, Ning-Ning Lu, Ning Li, Hui Fang, Ye-Xiong Li, Shu-Lian Wang
    European Journal of Cancer.2022; 174: 153.     CrossRef
  • Timing of Postmastectomy Radiotherapy Following Adjuvant Chemotherapy for High-Risk Breast Cancer: A Post-Hoc Analysis of a Randomised Controlled Clinical Trial
    Si-Ye Chen, Guang-Yi Sun, Yu Tang, Hao Jing, Yong-Wen Song, Jing Jin, Yue-Ping Liu, Xu-Ran Zhao, Yu-Chun Song, Bo Chen, Shu-Nan Qi, Yuan Tang, Ning-Ning Lu, Ning Li, Hui Fang, Ye-Xiong Li, Shu-Lian Wang
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • Social Determinants of Racial Disparities in Breast Cancer Mortality Among Black and White Women
    Oluwole Adeyemi Babatunde, Jan M. Eberth, Tisha Felder, Robert Moran, Samantha Truman, James R. Hebert, Jiajia Zhang, Swann Arp Adams
    Journal of Racial and Ethnic Health Disparities.2021; 8(1): 147.     CrossRef
  • How Does the Interval Between Completion of Adjuvant Chemotherapy and Initiation of Radiotherapy Impact Clinical Outcomes in Operable Breast Cancer Patients?
    Lu Cao, Cheng Xu, Gang Cai, Wei-Xiang Qi, Rong Cai, Shu-Bei Wang, Dan Ou, Min Li, Kun-Wei Shen, Jia-Yi Chen
    Annals of Surgical Oncology.2021; 28(4): 2155.     CrossRef
  • Saving the Breast Saves the Lives of Breast Cancer Patients
    Mohammad Esmaeil Akbari, Maryam Khayamzadeh, Hamid Reza Mirzaei, Afshin Moradi, Atieh Akbari, Farid Moradian, Neda Khalili
    International Journal of Surgical Oncology.2020; 2020: 1.     CrossRef
  • Timing of Chemotherapy and Radiotherapy Following Breast-Conserving Surgery for Early-Stage Breast Cancer: A Retrospective Analysis
    Si-Ye Chen, Yu Tang, Shu-Lian Wang, Yong-Wen Song, Hui Fang, Jian-Yang Wang, Hao Jing, Jiang-Hu Zhang, Guang-Yi Sun, Xu-Ran Zhao, Jing Jin, Yue-Ping Liu, Bo Chen, Shu-Nan Qi, Ning Li, Yuan Tang, Ning-Ning Lu, Hua Ren, Zi-Hao Yu, Ye-Xiong Li
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Evaluation of tissue computed tomography number changes and dosimetric shifts after conventional whole-breast irradiation in patients undergoing breast-conserving surgery
    Joo Hwan Lee, Dong Soo Lee, So Hyun Park, Young Kyu Lee, Jeong Soo Kim, Yong Seok Kim
    Tumor Biology.2018; 40(8): 101042831879188.     CrossRef
  • The influence of timing of radiation therapy following breast-conserving surgery on 10-year disease-free survival
    Marissa C van Maaren, Reini W Bretveld, Jan J Jobsen, Renske K Veenstra, Catharina GM Groothuis-Oudshoorn, Hendrik Struikmans, John H Maduro, Luc JA Strobbe, Philip MP Poortmans, Sabine Siesling
    British Journal of Cancer.2017; 117(2): 179.     CrossRef
  • 11,533 View
  • 126 Download
  • 10 Web of Science
  • 9 Crossref
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Objective Measurement of Cosmetic Outcomes of Breast Conserving Therapy Using BCCT.core
Tosol Yu, Keun-Yong Eom, Na Young Jang, Kyung Su Kim, Tae Ryool Koo, Jeanny Kwon, Byoung Hyuck Kim, Eunyoung Kang, Sung-Won Kim, Jae-Sung Kim, In Ah Kim
Cancer Res Treat. 2016;48(2):491-498.   Published online June 22, 2015
DOI: https://doi.org/10.4143/crt.2015.088
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The purpose of this study is to evaluate objective cosmetic outcomes and factors related to breast-conserving therapy (BCT) using the BCCT.core software.
Materials and Methods
Fifty-one patients who received BCT with informed consent were evaluated using the BCCT.core software. Patients were divided into two groups based on the BCCT score: excellent or good (n=42) vs. fair or poor (n=9). Analysis of clinical factors was performed to determine factors affecting cosmetic outcomes.
Results
The objective cosmetic outcome of BCT measured using the BCCT.core software was excellent in 10% of patients, good in 72%, and fair in 18%. None of the patients were classified as poor outcome. Tumor characteristics, systemic adjuvant therapy (chemotherapy and hormonal therapy), and radiation dose or energy of electron boost did not show correlation with the score measured by the BCCT.core program (p > 0.05). In univariate analysis, maximum dose within the breast (Dmax), width of tangential field, and excised tumor volume were smaller in patients with excellent or good by the BCCT.core compared to those with fair or poor (Dmax, 110.2±1.5% vs. 111.6±1.7%, p=0.019; width of tangential field, 8.0±1.1 cm vs. 8.6±0.7 cm, p=0.034; excised tumor volume, 64.0±35.8 cm3 vs. 95.3±54.4 cm3, p=0.067). In multivariate analysis, only Dmax was a significant factor for breast cosmetic outcome with a risk ratio of 1.697 (95% confidence interval, 1.006 to 2.863; p=0.047).
Conclusion
Objective measurement of cosmetic outcome of BCT using the BCCT.core software was feasible. The cosmetic outcome of BCT may be affected by the maximum dose within the breast.

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  • Impact of autologous breast reconstruction on bra fit
    Yen-Tung Liu, Novera H. Khan, Mary Catherine Bordes, Gregory P. Reece, Ashleigh M. Francis, Tzuan A. Chen, Karen Bravo, Mia K. Markey
    Supportive Care in Cancer.2024;[Epub]     CrossRef
  • Easy Anthropometric Measurements Are Representative of Baseline Values of Breast Q Values in Asymptomatic Women
    Giuseppe Catanuto, Nicola Rocco, Concetta G. Fichera, Ada Cinquerrui, Martina Rapisarda, Paolo Chiodini, Francesca Magnoni, Patrizia Dorangricchia, Valeria Sebri, Gabriella Pravettoni, Maurizio Bruno Nava, Francesco Caruso
    Healthcare.2024; 12(2): 268.     CrossRef
  • Outcomes of reconstructive techniques in breast cancer using BCCT. core software
    Sevgi Kurt, Ahmet Serkan İlgün, Enver Özkurt, Gürsel Soybir, Gül Alço, Çağlar Ünal, Filiz Elbüken Çelebi, Tomris Duymaz, Tuğba Kayan Tapan, Naziye Ak, Çetin Ordu, Vahit Özmen
    World Journal of Surgical Oncology.2024;[Epub]     CrossRef
  • Evaluating intra and inter-observer bias in the cosmetic rating for random vs. serial assessment of breast photographs
    Preeti Belani, Rima Pathak, Shraddha Kenekar, Gaurika Pokale, Pallavi Rane, Ashwini Chalke, Tabassum Wadasadawala
    The Royal College of Radiologists Open.2024; 2: 100152.     CrossRef
  • Comparison of Postoperative Breast Asymmetry Using Vectra 3D Imaging in Prepectoral Versus Subpectoral Implant-Based Breast Reconstruction
    Seung-Ho Choi, Sang-Oh Lee, Kyu-Jin Chung, Il-Kug Kim, Jun-Ho Lee
    Journal of Clinical Medicine.2024; 13(23): 7486.     CrossRef
  • Long-term Efficacy and Cosmetic Outcomes of Partial-breast Irradiation Using Multicatheter Interstitial Brachytherapy for Breast-conserving Therapy
    Kazuhiko SATO, Hiromi FUCHIKAMI, Naoko TAKEDA, Nana NATSUME, Masahiro KATO
    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2023; 84(2): 238.     CrossRef
  • Identification of key breast features using a neural network: applications of machine learning in the clinical setting of Plastic Surgery
    Nitzan Kenig, Javier Monton Echeverria, Luis De la Ossa
    Plastic & Reconstructive Surgery.2023;[Epub]     CrossRef
  • Breast cancer patient-reported outcome of factors influencing cosmetic satisfaction after breast-conserving therapy
    A. T. P. M. Brands-Appeldoorn, A. J. G. Maaskant-Braat, L. Janssen, L. A. D. M. van Osch, V. C. G. Tjan-Heijnen, R. M. H. Roumen
    Breast Cancer.2022; 29(1): 114.     CrossRef
  • BROWSE: A multicentre comparison of nine year outcomes in acellular dermal matrix based and complete submuscular implant-based immediate breast reconstruction-aesthetics, capsular contracture and patient reported outcomes
    Rebecca L. Wilson, Cliona C. Kirwan, Joe M. O'Donoghue, Richard A. Linforth, Richard K. Johnson, James R. Harvey
    European Journal of Surgical Oncology.2022; 48(1): 73.     CrossRef
  • Factors related to patient-reported cosmetic outcome after breast-conserving therapy for breast cancer
    A. T. P. M. Brands-Appeldoorn, R. C. M. Thomma, L. Janssen, A. J. G. Maaskant-Braat, V. C. G. Tjan-Heijnen, R. M. H. Roumen
    Breast Cancer Research and Treatment.2022; 191(3): 545.     CrossRef
  • Adaptation of BCCT Learning Model in Developing Religious Aspects of Children
    Abd Hamid Wahid, Muhammad Fajri, Hasan Baharun, Riana Imroatul Fitriyah, Arifatur Risqiyah
    Jurnal Obsesi : Jurnal Pendidikan Anak Usia Dini.2022; 6(4): 3439.     CrossRef
  • Methods of Esthetic Assessment after Adjuvant Whole-Breast Radiotherapy in Breast Cancer Patients: Evaluation of the BCCT.core Software and Patients’ and Physicians’ Assessment from the Randomized IMRT-MC2 Trial
    Tobias Forster, Clara Köhler, Melissa Dorn, Matthias Felix Häfner, Nathalie Arians, Laila König, Semi Ben Harrabi, Ingmar Schlampp, Eva Meixner, Vanessa Heinrich, Nicola Weidner, Michael Golatta, André Hennigs, Jörg Heil, Holger Hof, David Krug, Jürgen De
    Cancers.2022; 14(12): 3010.     CrossRef
  • Feasibility of anomaly score detected with deep learning in irradiated breast cancer patients with reconstruction
    Dong-Yun Kim, Soo Jin Lee, Eun-Kyu Kim, Eunyoung Kang, Chan Yeong Heo, Jae Hoon Jeong, Yujin Myung, In Ah Kim, Bum-Sup Jang
    npj Digital Medicine.2022;[Epub]     CrossRef
  • Breast Oncoplastic Resections: No Innovation Without Evaluation
    Sherif Monib, Mohamed Farag, Mohamed Ibrahim
    Indian Journal of Surgery.2021; 83(S2): 409.     CrossRef
  • Cosmetic Outcomes of a Phase 1 Dose Escalation Study of 5-Fraction Stereotactic Partial Breast Irradiation for Early Stage Breast Cancer
    Asal Rahimi, Howard E. Morgan, Dong W. Kim, Yuanyuan Zhang, Marilyn Leitch, Rachel Wooldridge, Sally Goudreau, Barbara Haley, Roshni Rao, Aeisha Rivers, Ann E. Spangler, Ryan T. Jones, Stella Stevenson, Jason Staley, Kevin Albuquerque, Chul Ahn, Sarah Neu
    International Journal of Radiation Oncology*Biology*Physics.2021; 110(3): 772.     CrossRef
  • Comparative study between laparoscopically harvested omental flap and glandular flap in immediate reconstruction after conservative surgery in breast cancer
    Waleed Y. El‐Sherpiny, Abdulhamid M. Abdelshafi, Mohamed Ghazaly, Ayman A. Elnemr, Ahmed A. Darwish, Mohamed A. Mlees
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    Javier Monton, Asia Torres, Maria Gijon, Luis Chang-Azancot, Nitzan Kenig, P. Camelia Trandafir, Joaquin Jordan, Ricardo Insausti
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  • Nueva metodología para medir simetría frontal en pacientes reconstruidas por cáncer de mama
    Lenia Sánchez Wals, Carlos Acosta-Batista, Oscar Luis Vera Pérez, Juan Jesús Lence Anta, Marco Marcasciano
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Circulating Plasma Biomarkers for TSU-68, an Oral Antiangiogenic Agent, in Patients with Metastatic Breast Cancer
Changhoon Yoo, Sung-Bae Kim, Jungsil Ro, Seock-Ah Im, Young-Hyuck Im, Jee Hyun Kim, Jin-Hee Ahn, Kyung Hae Jung, Hong Suk Song, Seok Yun Kang, Hee Sook Park, Hyun-Cheol Chung
Cancer Res Treat. 2016;48(2):499-507.   Published online July 14, 2015
DOI: https://doi.org/10.4143/crt.2015.089
AbstractAbstract PDFPubReaderePub
Purpose
This study analyzed the role of plasma biomarkers for TSU-68 in a previous phase II trial comparing TSU-68 plus docetaxel and docetaxel alone in patients with metastatic breast cancer.
Materials and Methods
A total of 77 patients were eligible for this study (38 in the TSU-68 plus docetaxel arm and 39 in the docetaxel alone arm). Blood samples were collected prior to the start of each cycle, and vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF)- AA, -AB, -BB, fibroblast growth factor, M30, C-reactive protein (CRP), and interleukin 6 (IL-6) levels were measured using enzyme linked immunosorbent assay. The primary endpoint was progression-free survival (PFS).
Results
In patients with baseline PDGF-AA ≥ median, median PFS was significantly worse in the TSU-68 plus docetaxel group than in the docetaxel alone group (5.4 months vs. 13.7 months, p=0.049), while a trend toward a PFS benefit was observed in those with baseline PDGF-AA < median (9.7 months vs. 4.0 months, p=0.18; p for interaction=0.03). In the TSU-68 plus docetaxel group, PFS showed significant association with fold changes in CRP (p=0.001), IL-6 (p < .001), PDGF-BB (p=0.02), and VEGF (p=0.047) following the first treatment cycle.
Conclusion
Baseline PDGF-AA levels and dynamics of VEGF, PDGF-BB, CRP, and IL-6 levels were predictive for the efficacy of TSU-68.
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18F-FDG/PET May Help to Identify a Subgroup of Patients with T1-T2 Breast Cancer and 1-3 Positive Lymph Nodes Who Are at a High Risk of Recurrence after Mastectomy
Jee Suk Chang, Jeongshim Lee, Hyun Jung Kim, Kyung Hwan Kim, Mijin Yun, Seung Il Kim, Ki Chang Keum, Chang-Ok Suh, Yong Bae Kim
Cancer Res Treat. 2016;48(2):508-517.   Published online September 9, 2015
DOI: https://doi.org/10.4143/crt.2015.172
AbstractAbstract PDFPubReaderePub
Purpose
The purpose of this study is to assess the utility of positron emission tomography (PET) for predicting recurrence among patients with T1-T2/N1 breast cancer who were treated with mastectomy. Materials and Methods Of 712 consecutive patients with T1-T2/N1 breast cancer treated during 2003-2012, 109 had undergone preoperative 18F-fluorodeoxyglucose/PET and were included. Metabolic (maximum standardized uptake value [SUVmax]), volumetric (metabolic tumor volume [MTV]), and combined (total lesion glycolysis [TLG]) indices were measured. The resulting values were analyzed and compared with clinical outcome.
Results
At the median follow-up of 46.7 months, the 3-year relapse-free survival (RFS) rate was 95.2%. SUVmax (area under curve, 0.824) was more useful than MTV or TLG as a means of identifying patients at high risk for any recurrence. In multivariate analysis, SUVmax remained an independent risk factor for RFS (p=0.006). Using the method of Contal and O’Quigley, a SUVmax threshold of 5.36 showed the best predictive performance. The PET-based highrisk group (≥ 5.36 in either breast or nodes) had more T1c-T2, high-grade, hormone-receptor negative, and invasive ductal carcinoma tumors than the low-risk group (< 5.36 in both breast and nodes). The prognosis was much worse when high SUVmax (≥ 5.36) was detected in nodes (p < 0.001). In the no-radiotherapy cohort, the PET-based high-risk group had increased risk of locoregional recurrence when compared to the low-risk group (p=0.037). Conclusion High SUVmax on preoperative PET showed association with elevated risk of locoregional recurrence and any recurrence. Pre-treatment PET may improve assessments of recurrence risk and clarify indications for post-mastectomy radiotherapy in this subset of patients.

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  • Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Early Standardized Uptake Value Reduction in Patients With Breast Cancer Receiving Neoadjuvant Chemotherapy
    Soong June Bae, Sung Gwe Ahn, Jung Hwan Ji, Chih Hao Chu, Dooreh Kim, Janghee Lee, Soeun Park, Chihwan Cha, Joon Jeong
    Journal of Breast Cancer.2022; 25(6): 485.     CrossRef
  • Significance of Metabolic Tumor Volume at Baseline and Reduction of Mean Standardized Uptake Value in 18F-FDG-PET/CT Imaging for Predicting Pathological Complete Response in Breast Cancers Treated with Preoperative Chemotherapy
    Tomoko Higuchi, Yukie Fujimoto, Hiromi Ozawa, Ayako Bun, Reiko Fukui, Yoshimasa Miyagawa, Michiko Imamura, Kazuhiro Kitajima, Koichiro Yamakado, Yasuo Miyoshi
    Annals of Surgical Oncology.2019; 26(7): 2175.     CrossRef
  • The ability of pre-treatment F-18 FDG PET/CT metabolic parameters for predicting axillary lymph node and distant metastasis and overall survival
    Burcak Yilmaz, Sedef Dağ, Nurhan Ergul, Tevfik Fikret Çermik
    Nuclear Medicine Communications.2019; 40(11): 1112.     CrossRef
  • Postmastectomy radiotherapy in T1-2 patients with one to three positive lymph nodes – Past, present and future
    Filip Kaššák, Christine Rossier, Cristina Picardi, Jacques Bernier
    The Breast.2019; 48: 73.     CrossRef
  • The prognostic value of SUVmax measuring on primary lesion and ALN by 18F-FDG PET or PET/CT in patients with breast cancer
    Wei Diao, Fangfang Tian, Zhiyun Jia
    European Journal of Radiology.2018; 105: 1.     CrossRef
  • Differential Prognostic Impact of Strong PD-L1 Expression and 18F-FDG Uptake in Triple-negative Breast Cancer
    Seo Hee Choi, Jee Suk Chang, Ja Seung Koo, Jong Won Park, Joo Hyuk Sohn, Ki Chang Keum, Chang-Ok Suh, Yong Bae Kim
    American Journal of Clinical Oncology.2018; 41(11): 1049.     CrossRef
  • Prediction of breast cancer recurrence using lymph node metabolic and volumetric parameters from 18F-FDG PET/CT in operable triple-negative breast cancer
    Yong-il Kim, Yong Joong Kim, Jin Chul Paeng, Gi Jeong Cheon, Dong Soo Lee, June-Key Chung, Keon Wook Kang
    European Journal of Nuclear Medicine and Molecular Imaging.2017; 44(11): 1787.     CrossRef
  • Tumor size and proliferative marker geminin rather than Ki67 expression levels significantly associated with maximum uptake of 18F-deoxyglucose levels on positron emission tomography for breast cancers
    Arisa Nishimukai, Natsuko Inoue, Ayako Kira, Masashi Takeda, Koji Morimoto, Kazuhiro Araki, Kazuhiro Kitajima, Takahiro Watanabe, Seiichi Hirota, Toyomasa Katagiri, Shoji Nakamori, Kouhei Akazawa, Yasuo Miyoshi, Renato Franco
    PLOS ONE.2017; 12(9): e0184508.     CrossRef
  • Prognostic Value of SUVmax of <sup>18</sup>F-FDG PET/CT in Early Stage Breast Cancer with No LN Metastasis
    Ryusuke Murakami, Yoshimitsu Fukushima, Hitomi Tani, Kotomi Iwata, Shinichiro Kumita, Maki Nakai, Tomoko Kurita, Keiko Yanagihara, Hiroyuki Takei, Miyuki Matsubara
    Open Journal of Medical Imaging.2017; 07(03): 112.     CrossRef
  • Volume-based metabolic parameter of breast cancer on preoperative 18F-FDG PET/CT could predict axillary lymph node metastasis
    Young-Sil An, Doo Kyoung Kang, Yongsik Jung, Tae Hee Kim
    Medicine.2017; 96(45): e8557.     CrossRef
  • Trends in the Application of Postmastectomy Radiotherapy for Breast Cancer With 1 to 3 Positive Axillary Nodes and Tumors ≤5 cm in the Modern Treatment Era
    Jee Suk Chang, Jung Eun Choi, Min Ho Park, Sung Hoo Jung, Byung Ock Choi, Hyung Seok Park, Seho Park, Yong Bae Kim
    Medicine.2016; 95(19): e3592.     CrossRef
  • Prognostic significance of preoperative 18F-FDG PET/CT for breast cancer subtypes
    Tomoko Higuchi, Arisa Nishimukai, Hiromi Ozawa, Yukie Fujimoto, Ayako Yanai, Yoshimasa Miyagawa, Keiko Murase, Michiko Imamura, Yuichi Takatsuka, Kazuhiro Kitajima, Kazuhito Fukushima, Yasuo Miyoshi
    The Breast.2016; 30: 5.     CrossRef
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VEGF and Ki-67 Overexpression in Predicting Poor Overall Survival in Adenoid Cystic Carcinoma
Seongyeol Park, Soo Jeong Nam, Bhumsuk Keam, Tae Min Kim, Yoon Kyung Jeon, Se-Hoon Lee, J. Hun Hah, Tack-Kyun Kwon, Dong-Wan Kim, Myung-Whun Sung, Dae Seog Heo, Yung-Jue Bang
Cancer Res Treat. 2016;48(2):518-526.   Published online July 14, 2015
DOI: https://doi.org/10.4143/crt.2015.093
AbstractAbstract PDFPubReaderePub
Purpose
The purpose of this study was to evaluate potential prognostic factors in patients with adenoid cystic carcinoma (ACC). Materials and Methods A total of 68 patients who underwent curative surgery and had available tissue were enrolled in this study. Their medical records and pathologic slides were reviewed and immunohistochemistry for basic fibroblast growth factor, fibroblast growth factor receptor (FGFR) 2, FGFR3, c-kit, Myb proto-oncogene protein, platelet-derived growth factor receptor beta, vascular endothelial growth factor (VEGF), and Ki-67 was performed. Univariate and multivariate analysis was performed for determination of disease-free survival (DFS) and overall survival (OS).
Results
In univariate analyses, primary site of nasal cavity and paranasal sinus (p=0.022) and Ki-67 expression of more than 7% (p=0.001) were statistically significant factors for poor DFS. Regarding OS, perineural invasion (p=0.032), high expression of VEGF (p=0.033), and high expression of Ki-67 (p=0.007) were poor prognostic factors. In multivariate analyses, primary site of nasal cavity and paranasal sinus (p=0.028) and high expression of Ki-67 (p=0.004) were independent risk factors for poor DFS, and high expression of VEGF (p=0.011) and Ki-67 (p=0.011) showed independent association with poor OS. Conclusion High expression of VEGF and Ki-67 were independent poor prognostic factors for OS in ACC.

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  • PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands
    Vasudha Mishra, Alka Singh, Michael Korzinkin, Xiangying Cheng, Claudia Wing, Viktoria Sarkisova, Ashwin L. Koppayi, Alexandra Pogorelskaya, Oksana Glushchenko, Manu Sundaresan, Venkat Thodima, Jack Carter, Koichi Ito, Peggy Scherle, Anna Trzcinska, Ivan
    Journal of Experimental & Clinical Cancer Research.2025;[Epub]     CrossRef
  • Vascular Endothelial Growth Factor Receptor Inhibitors for Recurrent or Metastatic Adenoid Cystic Carcinoma
    Camilla O. Hoff, Joao Manzi, Felippe Lazar Neto, Renata Ferrarotto
    JAMA Otolaryngology–Head & Neck Surgery.2024; 150(7): 587.     CrossRef
  • Sinonasal adenoid cystic carcinoma: preoperative apparent diffusion coefficient histogram analysis in prediction of prognosis and Ki-67 proliferation status
    Jingfeng Cheng, Quan Liu, Yuzhe Wang, Yang Zhan, Yin Wang, Dandan Shen, Yue Geng, Linying Guo, Zuohua Tang
    Japanese Journal of Radiology.2024;[Epub]     CrossRef
  • Analysis of Response and Progression Patterns of Tyrosine Kinase Inhibitors in Recurrent or Metastatic Adenoid Cystic Carcinoma: A Post Hoc Analysis of Two KCSG Phase II Trials
    Youjin Kim, Bhumsuk Keam, Eun Joo Kang, Jin-Soo Kim, Hye Ryun Kim, Keun-Wook Lee, Jung Hye Kwon, Kyoung Eun Lee, Yaewon Yang, Yoon Hee Choi, Min Kyoung Kim, Jun Ho Ji, Tak Yun, Moon Young Choi, Ki Hyeong Lee, Sung-Bae Kim, Myung-Ju Ahn
    Cancer Research and Treatment.2024; 56(4): 1068.     CrossRef
  • Interactive role of miR‐29, miR‐93, miR‐205, and VEGF in salivary adenoid cystic carcinoma
    Parisa Bayat, Nazanin Mahdavi, Shima Younespour, Neda Kardouni Khoozestani
    Clinical and Experimental Dental Research.2023; 9(1): 112.     CrossRef
  • Current understanding of adenoid cystic carcinoma in the gene expression and targeted therapy
    Quan-Quan Lin, Jin-Long Sun, Feng Wang, Hai-Zhong Zhang, Ge Zhou, Qing Xi
    Holistic Integrative Oncology.2023;[Epub]     CrossRef
  • Molecular Biology and Therapeutic Targets of Primitive Tracheal Tumors: Focus on Tumors Derived by Salivary Glands and Squamous Cell Carcinoma
    Alessandro Marchioni, Roberto Tonelli, Anna Valeria Samarelli, Gaia Francesca Cappiello, Alessandro Andreani, Luca Tabbì, Francesco Livrieri, Annamaria Bosi, Ottavia Nori, Francesco Mattioli, Giulia Bruzzi, Daniele Marchioni, Enrico Clini
    International Journal of Molecular Sciences.2023; 24(14): 11370.     CrossRef
  • A Phase II Trial of Rivoceranib, an Oral Vascular Endothelial Growth Factor Receptor 2 Inhibitor, for Recurrent or Metastatic Adenoid Cystic Carcinoma
    Glenn J. Hanna, Myung-Ju Ahn, Jameel Muzaffar, Bhumsuk Keam, Daniel W. Bowles, Deborah J. Wong, Alan L. Ho, Sung-Bae Kim, Francis Worden, Tak Yun, Xianzhang Meng, Jan M. Van Tornout, Maureen G. Conlan, Hyunseok Kang
    Clinical Cancer Research.2023; 29(22): 4555.     CrossRef
  • A Contemporary Review of Molecular Therapeutic Targets for Adenoid Cystic Carcinoma
    Lauren E. Miller, Vivienne Au, Tara E. Mokhtari, Deborah Goss, Daniel L. Faden, Mark A. Varvares
    Cancers.2022; 14(4): 992.     CrossRef
  • Treatment of Recurrent or Metastatic Adenoid Cystic Carcinoma
    Luana Guimaraes de Sousa, Felippe Lazar Neto, Jessica Lin, Renata Ferrarotto
    Current Oncology Reports.2022; 24(5): 621.     CrossRef
  • Metastatic Adenoid Cystic Carcinoma: Genomic Landscape and Emerging Treatments
    Luana Guimaraes de Sousa, Katarina Jovanovic, Renata Ferrarotto
    Current Treatment Options in Oncology.2022; 23(8): 1135.     CrossRef
  • The Therapeutic Landscape of Salivary Gland Malignancies—Where Are We Now?
    Robbert Cleymaet, Tijl Vermassen, Renaat Coopman, Hubert Vermeersch, Stijn De Keukeleire, Sylvie Rottey
    International Journal of Molecular Sciences.2022; 23(23): 14891.     CrossRef
  • Approaches to the Management of Metastatic Adenoid Cystic Carcinoma
    Rex H. Lee, Katherine C. Wai, Jason W. Chan, Patrick K. Ha, Hyunseok Kang
    Cancers.2022; 14(22): 5698.     CrossRef
  • Adenoid cystic carcinoma: a review of clinical features, treatment targets and advances in improving the immune response to monoclonal antibody therapy
    James Nightingale, Benedict Lum, Rahul Ladwa, Fiona Simpson, Benedict Panizza
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2021; 1875(2): 188523.     CrossRef
  • Apatinib in patients with recurrent or metastatic adenoid cystic carcinoma of the head and neck: a single-arm, phase II prospective study
    Guopei Zhu, Lin Zhang, Shengjin Dou, Rongrong Li, Jiang Li, Lulu Ye, Wen Jiang, Minjun Dong, Min Ruan, Wenjun Yang, Chenping Zhang
    Therapeutic Advances in Medical Oncology.2021;[Epub]     CrossRef
  • Impact of tumor site on the prognosis of salivary gland neoplasms: A systematic review and meta-analysis
    Erison Santana dos Santos, Carla Isabelly Rodrigues-Fernandes, Paul M. Speight, Syed Ali Khurram, Ibrahim Alsanie, Ana Gabriela Costa Normando, Ana Carolina Prado-Ribeiro, Thaís Bianca Brandão, Luiz Paulo Kowalski, Eliete Neves Silva Guerra, Marcio Ajudar
    Critical Reviews in Oncology/Hematology.2021; 162: 103352.     CrossRef
  • Molecular Markers that Matter in Salivary Malignancy
    Katherine C. Wai, Hyunseok Kang, Patrick K. Ha
    Otolaryngologic Clinics of North America.2021; 54(3): 613.     CrossRef
  • Asymptomatic Palatal Mass
    C. V. Divyambika, K. Satish Srinivas, S. Sathasiva Subramanian, S. Elengkumaran, N. Malathi
    Indian Journal of Dental Research.2021; 32(1): 120.     CrossRef
  • Anlotinib is effective in patients with advanced oral cancer?
    Chen Chu, Wei Shang, Yan Sun, Xiaochun Zhang
    Medical Hypotheses.2020; 137: 109578.     CrossRef
  • Shallow whole genome sequencing of adenoid cystic carcinomas of the salivary glands identifies specific chromosomal aberrations related to tumor progression
    R. Cordesmeyer, R. Laskawi, H. Schliephake, P. Kauffmann, J. Beck, K. Bornemann-Kolatzki, E. Schütz, P. Ströbel, S. Kueffer, A. Fichtner, F. Bremmer
    Oral Oncology.2020; 103: 104615.     CrossRef
  • Knockdown Rab11‐FIP2 inhibits migration and invasion of nasopharyngeal carcinoma via suppressing Rho GTPase signaling
    Guofei Feng, Liting Qin, Zhipeng Liao, Xiling Xiao, Bo Li, Wanmeng Cui, Libin Liang, Yingxi Mo, Guangwu Huang, Ping Li, Xiaoying Zhou, Zhe Zhang, Xue Xiao
    Journal of Cellular Biochemistry.2020; 121(2): 1072.     CrossRef
  • Major and minor salivary gland tumours
    Gemma Gatta, Marco Guzzo, Laura D. Locati, Mark McGurk, Franz Josef Prott
    Critical Reviews in Oncology/Hematology.2020; 152: 102959.     CrossRef
  • The value of MYB as a prognostic marker for adenoid cystic carcinoma: Meta‐analysis
    Xiangqi Liu, Dongru Chen, Xiaomei Lao, Yujie Liang
    Head & Neck.2019; 41(5): 1517.     CrossRef
  • New approaches in salivary gland carcinoma
    Caroline Even, Neus Baste, Marion Classe
    Current Opinion in Oncology.2019; 31(3): 169.     CrossRef
  • Study of MYB-NFIB chimeric gene expression, tumor angiogenesis, and proliferation in adenoid cystic carcinoma of salivary gland
    Junya Ono, Yasuo Okada
    Odontology.2018; 106(3): 238.     CrossRef
  • A phase II study of axitinib (AG-013736) in patients with incurable adenoid cystic carcinoma
    A.L. Ho, L. Dunn, E.J. Sherman, M.G. Fury, S.S. Baxi, R. Chandramohan, S. Dogan, L.G.T. Morris, G.D. Cullen, S. Haque, C.S. Sima, A. Ni, C.R. Antonescu, N. Katabi, D.G. Pfister
    Annals of Oncology.2016; 27(10): 1902.     CrossRef
  • The role of perineural invasion on head and neck adenoid cystic carcinoma prognosis: a systematic review and meta-analysis
    Jun Ju, Yun Li, Juan Chai, Chao Ma, Qianwei Ni, Zhiyuan Shen, Jianhua Wei, Moyi Sun
    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2016; 122(6): 691.     CrossRef
  • 14,097 View
  • 127 Download
  • 32 Web of Science
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Association between PD-L1 and HPV Status and the Prognostic Value of PD-L1 in Oropharyngeal Squamous Cell Carcinoma
Hae Su Kim, Ji Yun Lee, Sung Hee Lim, Keunchil Park, Jong-Mu Sun, Young Hyeh Ko, Chung-Hwan Baek, Young-ik Son, Han Sin Jeong, Yong Chan Ahn, Min-Young Lee, Mineui Hong, Myung-Ju Ahn
Cancer Res Treat. 2016;48(2):527-536.   Published online September 15, 2015
DOI: https://doi.org/10.4143/crt.2015.249
AbstractAbstract PDFPubReaderePub
Purpose
Oropharyngeal squamous cell carcinoma (OSCC) has been recognized as an immunosuppressive disease. Various mechanisms have been proposed for immune escape, including dysregulation of immune checkpoints such as the PD-1:PD-L1 pathway. We investigated the expression of programmed cell death-ligand 1 (PD-L1) in HPV-negative and HPV-positive OSCC to determine its prevalence and prognostic relevance.
Materials and Methods
Using immunohistochemistry, 133 cases of OSCC were evaluated for expression of PD-L1. Formalin-fixed paraffin-embedded tumor samples were stained with monoclonal antibody (clone 5H1) to PD-L1. PD-L1 positivity was defined as membrane staining in ≥20% of tumor cells. Correlations between PD-L1 expression and HPV status and survival parameters were analyzed.
Results
Of the 133 patients, 68% showed PD-L1 expression, and 67% of patients were positive for p16 expression by immunohistochemistry. No significant difference in PD-L1 expression was observed between HPV(-) and HPV(+) tumors (61% vs. 71%, p=0.274). No significant difference in age, gender, smoking history, location of tumor origin, or stage was observed according to PD-L1 status. With a median follow-up period of 44 months, older age (≥65) (p=0.017) and T3-4 stage (p<0.001) were associated with poor overall survival (OS), whereas PD-L1 expression did not affect OS in univariate and multivariate analysis.
Conclusion
PD-L1 expression was observed in the majority of OSCC patients regardless of HPV status. Further large prospective studies are required to determine the role of PD-L1 expression as a prognostic or predictive biomarker, and clinical studies of immune checkpoint inhibitors in OCSS are warranted regardless of HPV status.

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    Pooja Sharma Kala, Naveen Thapliyal, Bhawna Pant, Nitin Sharma, Hari Shankar Pandey
    Pathology - Research and Practice.2024; 254: 155133.     CrossRef
  • Référentiel national de traitement des carcinomes épidermoïdes des voies aérodigestives supérieures – Principes généraux de traitement
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    Bulletin du Cancer.2024; 111(4): 393.     CrossRef
  • PD-L1 expression in head and neck squamous cell carcinoma and its clinical significance: A prospective observational study from a tertiary care centre
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    Journal of Cancer Research and Therapeutics.2024; 20(1): 46.     CrossRef
  • Histologic and Genomic Analysis of Conjunctival SCC in African and American Cohorts Reveal UV Light and HPV Signatures and High Tumor Mutation Burden
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    Investigative Opthalmology & Visual Science.2024; 65(4): 24.     CrossRef
  • Considerable interlaboratory variation in PD‐L1 positivity for head and neck squamous cell carcinoma in the Netherlands— A nationwide evaluation study
    Maaike Anna Hempenius, Bregje M Koomen, Ivette A G Deckers, Sjoukje F Oosting, Stefan M Willems, Bert van der Vegt
    Histopathology.2024; 85(1): 133.     CrossRef
  • The Role of Estrogen and Estrogen Receptors in Head and Neck Tumors
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    Cancers.2024; 16(8): 1575.     CrossRef
  • PD-L1 Expression and Its Association With p16 in Head and Neck Squamous Cell Carcinoma in Southwestern Uganda
    Rita Nabulya, Raymond Atwine, Brian Ssenkumba, Yekosani Mitala, Jamilah Nabukenya
    Pathology and Laboratory Medicine International.2024; Volume 16: 1.     CrossRef
  • High‐risk HPV oncoproteins E6 and E7 and their interplay with the innate immune response: Uncovering mechanisms of immune evasion and therapeutic prospects
    Irene Lo Cigno, Federica Calati, Carlo Girone, Marta Catozzo, Marisa Gariglio
    Journal of Medical Virology.2024;[Epub]     CrossRef
  • PD-L1 immunohistochemical expression considering HPV status in oropharyngeal squamous cell carcinoma
    Raíssa Soares dos ANJOS, Marianne de Vasconcelos CARVALHO, Rayanna Thayse Florêncio COSTA, Belmiro Cavalcanti do Egito VASCONCELOS, Sandra Lúcia Dantas MORAES, Eduardo Piza PELLIZZER
    Brazilian Oral Research.2024;[Epub]     CrossRef
  • PD-1 and PD-L1 Expression Levels as a Potential Biomarker of Chronic Rhinosinusitis and Head and Neck Cancers
    Katarzyna Malinowska, Andrzej Kowalski, Anna Merecz-Sadowska, Milena Paprocka-Zjawiona, Przemysław Sitarek, Tomasz Kowalczyk, Hanna Zielińska-Bliźniewska
    Journal of Clinical Medicine.2023; 12(5): 2033.     CrossRef
  • Immunotherapy in oral cancer: Review
    Despoina Papaioannou, Spyridoula Petsali, Alida Ndreou, Fani Akritidou, Vasileios Zisis, Dimitrios Kavvadas, Athanasios Poulopoulos, Sofia Karachrysafi, Dimitrios Andreadis
    Balkan Journal of Dental Medicine.2023; 27(3): 129.     CrossRef
  • Programmed Death Ligand-1 Combined Positive Score Concordance and Interrater Reliability in Primary Tumors and Synchronous Lymph Node Metastases in Resected Cases of p16+ Oropharyngeal Squamous Cell Carcinoma
    Amandeep Kaur, Kristine Kuchta, William Watkin, Megan Sullivan, Lin Liu, Pouya Jamshidi, Nick Campbell, Bruce Brockstein, Ajit Paintal
    Archives of Pathology & Laboratory Medicine.2023; 147(4): 442.     CrossRef
  • Expression of immune checkpoint protein in oral squamous cell carcinoma and its clinicopathological correlation: A tertiary care center cross-sectional study
    Sonal Ratnakar, Madhu Kumar, Malti K. Maurya, Sumaira Qayoom, Mala Sagar, Suresh Babu, Vijay Kumar
    Journal of Oral and Maxillofacial Pathology.2023; 27(3): 597.     CrossRef
  • Commentary on “Clinicopathological features of programmed cell death-ligand 1 expression in patients with oral squamous cell carcinoma”
    Juan Francisco Peña-Cardelles, José Ernesto Moro-Rodríguez, José Luís Cebrián-Carretero, José Juan Pozo-Kreilinger
    Open Medicine.2022; 17(1): 227.     CrossRef
  • Prognostic Value of Programmed Death Ligand-1 Expression in Solid Tumors Irrespective of Immunotherapy Exposure: A Systematic Review and Meta-Analysis
    Ramy R. Saleh, Jordan L. Scott, Nicholas Meti, Danielle Perlon, Rouhi Fazelzad, Alberto Ocana, Eitan Amir
    Molecular Diagnosis & Therapy.2022; 26(2): 153.     CrossRef
  • Immunotherapy for head and neck cancer: Present and future
    Morena Fasano, Carminia Maria Della Corte, Raimondo Di Liello, Giuseppe Viscardi, Francesca Sparano, Maria Lucia Iacovino, Fernando Paragliola, Antonio Piccolo, Stefania Napolitano, Giulia Martini, Floriana Morgillo, Salvatore Cappabianca, Fortunato Ciard
    Critical Reviews in Oncology/Hematology.2022; 174: 103679.     CrossRef
  • Differences in PD-L1 Expression between oral and oropharyngeal squamous cell carcinoma
    Sebastian Blatt, Maximilian Krüger, Constantin Rump, Stefanie Zimmer, Keyvan Sagheb, Julian Künzel, Afsheen Raza
    PLOS ONE.2022; 17(5): e0269136.     CrossRef
  • Expression of PD-L1 is HPV/P16-independent in oral squamous cell carcinoma
    Kit Kitichotkul, Nirush Lertprasertsuke, Sompid Kintarak, Surawut Pongsiriwet, Warit Powcharoen, Anak Iamaroon
    Heliyon.2022; 8(10): e10667.     CrossRef
  • Survival Outcomes of Complete Pulmonary Metastasectomy for Head and Neck Squamous Cell Carcinomas
    Hiroaki Kuroda, Shin Koyama, Mingyon Mun, Jun Nakajima, Kazuhito Funai, Ichiro Yoshino, Yoshikane Yamauchi, Masafumi Kawamura
    Cancer Management and Research.2022; Volume 14: 3095.     CrossRef
  • Expression of PD-L1 is HPV/P16-Independent in Oral Squamous Cell Carcinoma
    Kit Kitichotkul, Nirush Lertprasertsuke, Sompid Kintarak, Surawut Pongsiriwet, Warit Powcharoen, Anak Iamaroon
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • CMTM6 and PD-1/PD-L1 overexpression is associated with the clinical characteristics of malignancy in oral squamous cell carcinoma
    Songtao Zhang, Qiujie Yan, Song Wei, Xiaobo Feng, Miaomiao Xue, Lina Liu, Jili Cui, Yuanyuan Zhang
    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2021; 132(2): 202.     CrossRef
  • PD-L1 expression in anogenital and oropharyngeal squamous cell carcinomas associated with different clinicopathological features, HPV status and prognosis: a meta-analysis
    Yuan Qin, Jiaochen Luan, Xiang Zhou, Ying Li
    Bioscience Reports.2021;[Epub]     CrossRef
  • Resistance mechanisms to programmed cell death protein 1 and programmed death ligand 1 inhibitors
    Parmida Sadat Pezeshki, Pouya Mahdavi Sharif, Nima Rezaei
    Expert Opinion on Biological Therapy.2021; 21(12): 1575.     CrossRef
  • PD-L1 TESTING AND IMMUNOTHERAPY SELECTION – EARLY LABORATORY EXPERIENCE AND ITS POTENTIAL ROLE IN HEAD AND NECK CANCER MANAGEMENT
    Bancu Bancu, Richard Cowan, Anshuman Chaturvedi
    Archive of Clinical Cases.2021; 8(1): 14.     CrossRef
  • Immunotherapy Advances in Locally Advanced and Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma and Its Relationship With Human Papillomavirus
    Huanhuan Wang, Qin Zhao, Yuyu Zhang, Qihe Zhang, Zhuangzhuang Zheng, Shiyu Liu, Zijing Liu, Lingbin Meng, Ying Xin, Xin Jiang
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • The effects of PD-1/PD-L1 checkpoint inhibitors on recurrent/metastatic head and neck squamous cell carcinoma: a critical review of the literature and meta-analysis
    Emily Clarke, Jesper Grau Eriksen, Sarah Barrett
    Acta Oncologica.2021; 60(11): 1534.     CrossRef
  • Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma
    Alexander A. Strait, Rachel A. Woolaver, Spencer C. Hall, Christian D. Young, Sana D. Karam, Antonio Jimeno, Yan Lan, David Raben, Jing H. Wang, Xiao-Jing Wang
    Communications Biology.2021;[Epub]     CrossRef
  • Commentary on 'Relationship of programmed death ligand-1 expression with clinicopathological features and prognosis in patients with oral squamous cell carcinoma: A meta-analysis' (He et al., (2020) Archives of Oral Biology, 114, 104717)
    Juan Francisco Peña-Cardelles, José Ernesto Moro-Rodríguez, José Luís Cebrián-Carretero, José Juan Pozo-Kreilinger
    Archives of Oral Biology.2021; 132: 105274.     CrossRef
  • Relationship between Tumor Mutational Burden, PD-L1, Patient Characteristics, and Response to Immune Checkpoint Inhibitors in Head and Neck Squamous Cell Carcinoma
    Kimberly M. Burcher, Jeffrey W. Lantz, Elena Gavrila, Arianne Abreu, Jack T. Burcher, Andrew T. Faucheux, Amy Xie, Clayton Jackson, Alexander H. Song, Ryan T. Hughes, Thomas Lycan, Paul M. Bunch, Cristina M. Furdui, Umit Topaloglu, Ralph B. D’Agostino, We
    Cancers.2021; 13(22): 5733.     CrossRef
  • Prognostic Significance of PD-L1 Expression In Patients With Primary Oropharyngeal Squamous Cell Carcinoma: A Meta-Analysis
    Jerry Polesel, Anna Menegaldo, Giancarlo Tirelli, Vittorio Giacomarra, Roberto Guerrieri, Lorena Baboci, Mariateresa Casarotto, Valentina Lupato, Giuseppe Fanetti, Paolo Boscolo-Rizzo, Elisabetta Fratta
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Tumor Immunity and Immunotherapy for HPV-Related Cancers
    Achraf A. Shamseddine, Bharat Burman, Nancy Y. Lee, Dmitriy Zamarin, Nadeem Riaz
    Cancer Discovery.2021; 11(8): 1896.     CrossRef
  • An update of knowledge on PD‐L1 in head and neck cancers: Physiologic, prognostic and therapeutic perspectives
    Daniel Lenouvel, Miguel Ángel González‐Moles, Asmae Talbaoui, Pablo Ramos‐García, Lucía González‐Ruiz, Isabel Ruiz‐Ávila, José Antonio Gil‐Montoya
    Oral Diseases.2020; 26(3): 511.     CrossRef
  • A treatise on endothelial biology and exosomes: homage to Theresa Maria Listowska Whiteside
    N. Ludwig, M. T. Lotze
    HNO.2020; 68(2): 71.     CrossRef
  • PD-L1 expression and survival in p16-negative and -positive squamous cell carcinomas of the vulva
    Bastian Czogalla, Deborah Pham, Fabian Trillsch, Miriam Rottmann, Julia Gallwas, Alexander Burges, Sven Mahner, Thomas Kirchner, Udo Jeschke, Doris Mayr, Elisa Schmoeckel
    Journal of Cancer Research and Clinical Oncology.2020; 146(3): 569.     CrossRef
  • Prognostic impact of PD-L1 in oropharyngeal cancer after primary curative radiotherapy and relation to HPV and tobacco smoking
    Jacob K. Lilja-Fischer, Jesper G. Eriksen, Jeanette B. Georgsen, Thao T. Vo, Stine R. Larsen, Jonathan Cheng, Michael Busch-Sørensen, Deepti Aurora-Garg, Torben Steiniche, Jens Overgaard
    Acta Oncologica.2020; 59(6): 666.     CrossRef
  • Immunologic impact of chemoradiation in cervical cancer and how immune cell infiltration could lead toward personalized treatment
    Lien Lippens, Mieke Van Bockstal, Emiel A. De Jaeghere, Philippe Tummers, Amin Makar, Sofie De Geyter, Koen Van de Vijver, An Hendrix, Katrien Vandecasteele, Hannelore Denys
    International Journal of Cancer.2020; 147(2): 554.     CrossRef
  • Current Understanding of the Mechanisms Underlying Immune Evasion From PD-1/PD-L1 Immune Checkpoint Blockade in Head and Neck Cancer
    Victor C. Kok
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • The different role of PD-L1 in head and neck squamous cell carcinomas: A meta-analysis
    Hui Tang, Xiang Zhou, Yu Ye, Yi Zhou, Chengyu Wu, Yan Xu
    Pathology - Research and Practice.2020; 216(1): 152768.     CrossRef
  • Relationship of programmed death ligand-1 expression with clinicopathological features and prognosis in patients with oral squamous cell carcinoma: A meta-analysis
    Jing He, Xiao-Fang Chen, Ming-Gao Xu, Jing Zhao
    Archives of Oral Biology.2020; 114: 104717.     CrossRef
  • The role of transforming growth factor‐beta in immune suppression and chronic inflammation of squamous cell carcinomas
    Alexander A. Strait, Xiao‐Jing Wang
    Molecular Carcinogenesis.2020; 59(7): 745.     CrossRef
  • The roles of programmed death ligand 1 in virus-associated cancers
    Morvarid Golrokh Mofrad, Donya Taghizadeh Maleki, Ebrahim Faghihloo
    Infection, Genetics and Evolution.2020; 84: 104368.     CrossRef
  • Clinicopathological features of programmed cell death-ligand 1 expression in patients with oral squamous cell carcinoma
    Yong-Xin Cui, Xian-Shuang Su
    Open Medicine.2020; 15(1): 292.     CrossRef
  • The tumor immune microenvironment and its implications for clinical outcome in patients with oropharyngeal squamous cell carcinoma
    Dominik Gurin, Marek Slavik, Marketa Hermanova, Iveta Selingerova, Tomas Kazda, Michal Hendrych, Tetiana Shatokhina, Marcela Vesela
    Journal of Oral Pathology & Medicine.2020; 49(9): 886.     CrossRef
  • PD-L1 Expression and a High Tumor Infiltrate of CD8+ Lymphocytes Predict Outcome in Patients with Oropharyngeal Squamous Cells Carcinoma
    Nora Wuerdemann, Sibel E. Gültekin, Katharina Pütz, Claus Wittekindt, Christian U. Huebbers, Shachi J. Sharma, Hans Eckel, Anna B. Schubotz, Stefan Gattenlöhner, Reinhard Büttner, Ernst-Jan Speel, Jens P. Klussmann, Steffen Wagner, Alexander Quaas
    International Journal of Molecular Sciences.2020; 21(15): 5228.     CrossRef
  • Evaluation of p16 in Epithelial Ovarian Cancer for a 10-Year Study in Northeast China: Significance of HPV in Correlation with PD-L1 Expression


    Xinxin Yang, Qi You, Guodong Yao, Jingshu Geng, Rong Ma, Hongxue Meng
    Cancer Management and Research.2020; Volume 12: 6747.     CrossRef
  • Prevalence of high-risk human papillomavirus and its genotype distribution in head and neck squamous cell carcinomas
    Yuil Kim, Young-Hoon Joo, Min-Sik Kim, Youn Soo Lee
    Journal of Pathology and Translational Medicine.2020; 54(5): 411.     CrossRef
  • The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer
    Xin-wei Qiao, Jian Jiang, Xin Pang, Mei-chang Huang, Ya-jie Tang, Xin-hua Liang, Ya-ling Tang
    Frontiers in Immunology.2020;[Epub]     CrossRef
  • Immune Escape Mechanisms and Their Clinical Relevance in Head and Neck Squamous Cell Carcinoma
    Barbara Seliger, Chiara Massa, Bo Yang, Daniel Bethmann, Matthias Kappler, Alexander Walter Eckert, Claudia Wickenhauser
    International Journal of Molecular Sciences.2020; 21(19): 7032.     CrossRef
  • PD-L1 expression in the microenvironment and the response to checkpoint inhibitors in head and neck squamous cell carcinoma
    D. Evrard, M. Hourseau, A. Couvelard, V. Paradis, H. Gauthier, E. Raymond, C. Halimi, B. Barry, S. Faivre
    OncoImmunology.2020;[Epub]     CrossRef
  • Expression of immunoregulatory molecules PD-L1 and PD-1 in oral cancer and precancerous lesions: A cohort study of Japanese patients
    Atsumu Kouketsu, Ikuro Sato, Mariko Oikawa, Yoshinaka Shimizu, Hiroki Saito, Tetsu Takahashi, Hiroyuki Kumamoto
    Journal of Cranio-Maxillofacial Surgery.2019; 47(1): 33.     CrossRef
  • The value of immunotherapy in head and neck cancer
    Paolo Manca, Luis E. Raez, Matthew Salzberg, Jorge Sanchez, Brian Hunis, Christian Rolfo
    Expert Opinion on Biological Therapy.2019; 19(1): 35.     CrossRef
  • Oral and Oropharyngeal squamous cell carcinoma: prognostic and predictive parameters in the etiopathogenetic route
    Iacopo Panarese, Gabriella Aquino, Andrea Ronchi, Francesco Longo, Marco Montella, Immacolata Cozzolino, Giuseppe Roccuzzo, Giuseppe Colella, Michele Caraglia, Renato Franco
    Expert Review of Anticancer Therapy.2019; 19(2): 105.     CrossRef
  • The Double-Edged Sword—How Human Papillomaviruses Interact With Immunity in Head and Neck Cancer
    Hao-fan Wang, Sha-sha Wang, Ya-Jie Tang, Yu Chen, Min Zheng, Ya-ling Tang, Xin-hua Liang
    Frontiers in Immunology.2019;[Epub]     CrossRef
  • The protective role of carnosic acid in ischemic/reperfusion injury through regulation of autophagy under T2DM
    Min Hu, Tianyu Li, Zixiang Bo, Feixiang Xiang
    Experimental Biology and Medicine.2019; 244(7): 602.     CrossRef
  • Clinical impact of PD-L1 and PD-1 expression in squamous cell cancer of the vulva
    Fabinshy Thangarajah, Bernd Morgenstern, Caroline Pahmeyer, Lars Mortimer Schiffmann, Julian Puppe, Peter Mallmann, Stefanie Hamacher, Reinhard Buettner, Christina Alidousty, Barbara Holz, Andreas H. Scheel, Anne Maria Schultheis
    Journal of Cancer Research and Clinical Oncology.2019; 145(6): 1651.     CrossRef
  • The emergence of long-term survivors in recurrent and metastatic squamous cell head and neck cancer
    Florian Castet, Jesús Brenes, Miren Taberna, Ricard Mesía
    Current Opinion in Oncology.2019; 31(3): 160.     CrossRef
  • PYHIN genes as potential biomarkers for prognosis of human papillomavirus-positive or -negative head and neck squamous cell carcinomas
    Giuseppe Riva, Giancarlo Pecorari, Matteo Biolatti, Sara Pautasso, Irene Lo Cigno, Massimiliano Garzaro, Valentina Dell’Oste, Santo Landolfo
    Molecular Biology Reports.2019; 46(3): 3333.     CrossRef
  • PD-L1/PD1 Expression, Composition of Tumor-Associated Immune Infiltrate, and HPV Status in Conjunctival Squamous Cell Carcinoma
    Priyadharsini Nagarajan, Christian El-Hadad, Stephen K. Gruschkus, Jing Ning, Courtney W. Hudgens, Oded Sagiv, Neil Gross, Michael T. Tetzlaff, Bita Esmaeli
    Investigative Opthalmology & Visual Science.2019; 60(6): 2388.     CrossRef
  • PD-L1-specific helper T-cells exhibit effective antitumor responses: new strategy of cancer immunotherapy targeting PD-L1 in head and neck squamous cell carcinoma
    Yui Hirata-Nozaki, Takayuki Ohkuri, Kenzo Ohara, Takumi Kumai, Marino Nagata, Shohei Harabuchi, Akemi Kosaka, Toshihiro Nagato, Kei Ishibashi, Kensuke Oikawa, Naoko Aoki, Mizuho Ohara, Yasuaki Harabuchi, Yuji Uno, Hidehiro Takei, Esteban Celis, Hiroya Kob
    Journal of Translational Medicine.2019;[Epub]     CrossRef
  • 転移・再発頭頸部がんに対する分子標的薬と免疫チェックポイント阻害薬のエビデンス

    Nippon Jibiinkoka Gakkai Kaiho.2019; 122(6): 848.     CrossRef
  • Prognostic Value of Combined Programmed Cell Death 1 Ligand and p16 Expression Predicting Responsiveness to Radiotherapy in Patients with Oropharyngeal Squamous Cell Carcinoma
    Minsu Kwon, Dae Hwan Kim, Ki Ju Cho, Youngchul Kim, Jin Pyeong Kim, Bae Kwon Jeong, Jong Sil Lee, Ji-Hyun Seo, Jung Je Park
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2019; 62(12): 712.     CrossRef
  • Immunotherapies and Future Combination Strategies for Head and Neck Squamous Cell Carcinoma
    Valerie Cristina, Ruth Gabriela Herrera-Gómez, Petr Szturz, Vittoria Espeli, Marco Siano
    International Journal of Molecular Sciences.2019; 20(21): 5399.     CrossRef
  • The expression of PD-L1 in salivary gland carcinomas
    Domenic Vital, Kristian Ikenberg, Holger Moch, Matthias Rössle, Gerhard F. Huber
    Scientific Reports.2019;[Epub]     CrossRef
  • Prognostic value of immune checkpoint molecules in head and neck cancer: a meta-analysis
    Yi-Qun Jia, Bo Yang, Li-Ling Wen, Wen-Xin Mu, Zhi Wang, Bin Cheng
    Aging.2019; 11(2): 501.     CrossRef
  • Targeting the EGFR and Immune Pathways in Squamous Cell Carcinoma of the Head and Neck (SCCHN): Forging a New Alliance
    Nabil F. Saba, Zhuo Gerogia Chen, Missak Haigentz, Paolo Bossi, Alessandra Rinaldo, Juan P. Rodrigo, Antti A. Mäkitie, Robert P. Takes, Primoz Strojan, Jan B. Vermorken, Alfio Ferlito
    Molecular Cancer Therapeutics.2019; 18(11): 1909.     CrossRef
  • PD-L1 Expression in Tumor Cells Is an Independent Unfavorable Prognostic Factor in Oral Squamous Cell Carcinoma
    Juan C. de Vicente, Tania Rodríguez-Santamarta, Juan P. Rodrigo, Verónica Blanco-Lorenzo, Eva Allonca, Juana M. García-Pedrero
    Cancer Epidemiology, Biomarkers & Prevention.2019; 28(3): 546.     CrossRef
  • Beyond the Percentages of PD-L1-Positive Tumor Cells: Induced Versus Constitutive PD-L1 Expression in Primary and Metastatic Head and Neck Squamous Cell Carcinoma
    Theresa Scognamiglio, Yao-Tseng Chen
    Head and Neck Pathology.2018; 12(2): 221.     CrossRef
  • The Current State of Biological and Clinical Implications of Human Papillomavirus-Related Oropharyngeal Cancer
    Shao Hui Huang, Brian O'Sullivan, John Waldron
    Seminars in Radiation Oncology.2018; 28(1): 17.     CrossRef
  • Implications of the tumor immune microenvironment for staging and therapeutics
    Janis M Taube, Jérôme Galon, Lynette M Sholl, Scott J Rodig, Tricia R Cottrell, Nicolas A Giraldo, Alexander S Baras, Sanjay S Patel, Robert A Anders, David L Rimm, Ashley Cimino-Mathews
    Modern Pathology.2018; 31(2): 214.     CrossRef
  • Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments
    Benjamin Solomon, Richard J. Young, Danny Rischin
    Seminars in Cancer Biology.2018; 52: 228.     CrossRef
  • Immuno-oncology in head and neck squamous cell cancers: News from clinical trials, emerging predictive factors and unmet needs
    Stefano Cavalieri, Licia Rivoltini, Cristiana Bergamini, Laura D. Locati, Lisa Licitra, Paolo Bossi
    Cancer Treatment Reviews.2018; 65: 78.     CrossRef
  • Clinical implication of programmed cell death-1 ligand-1 expression in tonsillar squamous cell carcinoma in association with intratumoral heterogeneity, human papillomavirus, and epithelial-to-mesenchymal transition
    Mi Jung Kwon, Young-Soo Rho, Eun Sook Nam, Seong Jin Cho, Hye-Rim Park, Soo Kee Min, Jinwon Seo, Ji-Young Choe, Eun Soo Kim, Bumjung Park, Mineui Hong, Kyueng-Whan Min
    Human Pathology.2018; 80: 28.     CrossRef
  • The Role of the Programmed Death Receptor-1/Programmed Death Ligand-1: Immunologic Checkpoint in Human Papillomavirus–Associated Head and Neck Squamous Cell Carcinoma
    Christine Kunkle, Flavia G Rosado
    Archives of Pathology & Laboratory Medicine.2018; 142(6): 719.     CrossRef
  • Genomic Landscapes of EBV-Associated Nasopharyngeal Carcinoma vs. HPV-Associated Head and Neck Cancer
    Hoi-Lam Ngan, Lan Wang, Kwok-Wai Lo, Vivian Wai Yan Lui
    Cancers.2018; 10(7): 210.     CrossRef
  • PD‐1 and PD‐L1 expression in HNSCC primary cancer and related lymph node metastasis – impact on clinical outcome
    Sven Schneider, Lorenz Kadletz, Robert Wiebringhaus, Lukas Kenner, Edgar Selzer, Thorsten Füreder, Orsolya Rajky, Anna S Berghoff, Matthias Preusser, Gregor Heiduschka
    Histopathology.2018; 73(4): 573.     CrossRef
  • The prognostic role of PD-L1 expression for survival in head and neck squamous cell carcinoma: A systematic review and meta-analysis
    Wei-fa Yang, May C.M. Wong, Peter J. Thomson, Kar-Yan Li, Yu-xiong Su
    Oral Oncology.2018; 86: 81.     CrossRef
  • Prognostic value of PD -L1 expression in patients with primary solid tumors
    Xiao Xiang, Peng-Cheng Yu, Di Long, Xiao-Li Liao, Sen Zhang, Xue-Mei You, Jian-Hong Zhong, Le-Qun Li
    Oncotarget.2018; 9(4): 5058.     CrossRef
  • Drug-Sensitivity Screening and Genomic Characterization of 45 HPV-Negative Head and Neck Carcinoma Cell Lines for Novel Biomarkers of Drug Efficacy
    Tatiana Lepikhova, Piia-Riitta Karhemo, Riku Louhimo, Bhagwan Yadav, Astrid Murumägi, Evgeny Kulesskiy, Mikko Kivento, Harri Sihto, Reidar Grénman, Stina M. Syrjänen, Olli Kallioniemi, Tero Aittokallio, Krister Wennerberg, Heikki Joensuu, Outi Monni
    Molecular Cancer Therapeutics.2018; 17(9): 2060.     CrossRef
  • Immune check point inhibitors for head and neck cancer
    Naomi Kiyota
    Toukeibu Gan.2018; 44(4): 336.     CrossRef
  • Immune check point inhibitors for head and neck cancer and its proper management on utilizing head and neck cancer collaborative program
    Naomi Kiyota
    Journal of Japanese Society of Oral Oncology.2018; 30(4): 144.     CrossRef
  • Is There Evidence for the Presence and Relevance of the PD-1/PD-L1 Pathway in Oral Squamous Cell Carcinoma? Hints From an Immunohistochemical Study
    Matthias Troeltzsch, Timothy Woodlock, Alix Pianka, Sven Otto, Markus Troeltzsch, Michael Ehrenfeld, Thomas Knösel
    Journal of Oral and Maxillofacial Surgery.2017; 75(5): 969.     CrossRef
  • Actualités sur l’immunothérapie en pathologie des voies aérodigestives supérieures
    Sophie Outh-Gauer, Christophe Le Tourneau, Chloé Broudin, Florian Scotte, Hélène Roussel, Stéphane Hans, Marion Mandavit, Eric Tartour, Cécile Badoual
    Annales de Pathologie.2017; 37(1): 79.     CrossRef
  • Overview of Sinonasal and Ventral Skull Base Malignancy Management
    Peter F. Svider, Michael Setzen, Soly Baredes, James K. Liu, Jean Anderson Eloy
    Otolaryngologic Clinics of North America.2017; 50(2): 205.     CrossRef
  • PD-L1 expression and CD8+ infiltration shows heterogeneity in Juvenile Recurrent Respiratory Papillomatosis
    Tingyu Liu, Max Greenberg, Carissa Wentland, Brandon Sepe, Sarah Bowe, Gillian Diercks, Tiffany Huynh, Mari Mino-Kenudson, Richard Schlegel, David Kodack, Cyril Benes, Jeffrey Engelman, Christopher Hartnick
    International Journal of Pediatric Otorhinolaryngo.2017;[Epub]     CrossRef
  • Programmed cell death ligand 1 as a biomarker in head and neck cancer
    Sara I. Pai, William C. Faquin
    Cancer Cytopathology.2017; 125(7): 529.     CrossRef
  • Turning the tide: Clinical utility of PD-L1 expression in squamous cell carcinoma of the head and neck
    Astrid De Meulenaere, Tijl Vermassen, Sandrine Aspeslagh, Wouter Huvenne, Jo Van Dorpe, Liesbeth Ferdinande, Sylvie Rottey
    Oral Oncology.2017; 70: 34.     CrossRef
  • Time to change perspectives on HPV in oropharyngeal cancer. A systematic review of HPV prevalence per oropharyngeal sub-site the last 3 years
    Linnea Haeggblom, Torbjörn Ramqvist, Massimo Tommasino, Tina Dalianis, Anders Näsman
    Papillomavirus Research.2017; 4: 1.     CrossRef
  • The PD-1/PD-L1 axis and human papilloma virus in patients with head and neck cancer after adjuvant chemoradiotherapy: A multicentre study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)
    Panagiotis Balermpas, Franz Rödel, Mechthild Krause, Annett Linge, Fabian Lohaus, Michael Baumann, Inge Tinhofer, Volker Budach, Ali Sak, Martin Stuschke, Eleni Gkika, Anca-Ligia Grosu, Amir Abdollahi, Jürgen Debus, Stefan Stangl, Ute Ganswindt, Claus Bel
    International Journal of Cancer.2017; 141(3): 594.     CrossRef
  • Prognostic value of programmed cell death ligand 1 expression in patients with head and neck cancer: A systematic review and meta-analysis
    Ji Li, Ping Wang, Youliang Xu, Jung Weon Lee
    PLOS ONE.2017; 12(6): e0179536.     CrossRef
  • Association between PD-L1 and HPV status and the prognostic value for HPV treatment in premalignant cervical lesion patients
    Feng Yang-Chun, Cheng Zhen-Zhen, Huang Yan-Chun, Ma Xiu-Min
    Medicine.2017; 96(25): e7270.     CrossRef
  • Expressions of programmed death (PD)‐1 and PD‐1 ligand (PD‐L1) in cervical intraepithelial neoplasia and cervical squamous cell carcinomas are of prognostic value and associated with human papillomavirus status
    Wen Yang, Yan‐Ping Lu, Yi‐Zhou Yang, Jia‐Rui Kang, Yi‐Duo Jin, Hong‐Wei Wang
    Journal of Obstetrics and Gynaecology Research.2017; 43(10): 1602.     CrossRef
  • Safety and Antitumor Activity of Pembrolizumab in Patients With Programmed Death-Ligand 1–Positive Nasopharyngeal Carcinoma: Results of the KEYNOTE-028 Study
    Chiun Hsu, Se-Hoon Lee, Samuel Ejadi, Caroline Even, Roger B. Cohen, Christophe Le Tourneau, Janice M. Mehnert, Alain Algazi, Emilie M.J. van Brummelen, Sanatan Saraf, Pradeep Thanigaimani, Jonathan D. Cheng, Aaron R. Hansen
    Journal of Clinical Oncology.2017; 35(36): 4050.     CrossRef
  • Human papillomavirus-related oropharyngeal cancer
    M. Taberna, M. Mena, M.A. Pavón, L. Alemany, M.L. Gillison, R. Mesía
    Annals of Oncology.2017; 28(10): 2386.     CrossRef
  • Circulating tumour cell PD-L1 test for head and neck cancers
    Arutha Kulasinghe, Liz Kenny, Chamindie Punyadeera
    Oral Oncology.2017; 75: 6.     CrossRef
  • Tumor PD-L1 status and CD8+ tumor-infiltrating T cells: markers of improved prognosis in oropharyngeal cancer
    Astrid De Meulenaere, Tijl Vermassen, Sandrine Aspeslagh, Philippe Deron, Fréderic Duprez, Debby Laukens, Jo Van Dorpe, Liesbeth Ferdinande, Sylvie Rottey
    Oncotarget.2017; 8(46): 80443.     CrossRef
  • Characterization of tumor-associated T-lymphocyte subsets and immune checkpoint molecules in head and neck squamous cell carcinoma
    Axel Lechner, Hans Schlößer, Sacha I. Rothschild, Martin Thelen, Sabrina Reuter, Peter Zentis, Alexander Shimabukuro-Vornhagen, Sebastian Theurich, Kerstin Wennhold, Maria Garcia-Marquez, Lars Tharun, Alexander Quaas, Astrid Schauss, Jörg Isensee, Tim Huc
    Oncotarget.2017; 8(27): 44418.     CrossRef
  • Tumoral PD-L1 expression defines a subgroup of poor-prognosis vulvar carcinomas with non-viral etiology
    Thomas Hecking, Thore Thiesler, Cynthia Schiller, Jean-Marc Lunkenheimer, Tiyasha H. Ayub, Andrea Rohr, Mateja Condic, Mignon-Denise Keyver-Paik, Rolf Fimmers, Jutta Kirfel, Walther Kuhn, Glen Kristiansen, Kirsten Kübler
    Oncotarget.2017; 8(54): 92890.     CrossRef
  • Evaluation of PD-L1 Expression in Tumor Tissue of Patients with Lung Carcinoma and Correlation with Clinical and Demographic Data
    Gustavo Dix Junqueira Pinto, Luciano de Souza Viana, Cristovam Scapulatempo Neto, Sérgio Vicente Serrano
    Journal of Immunology Research.2016; 2016: 1.     CrossRef
  • Development of a programmed cell death ligand-1 immunohistochemical assay validated for analysis of non-small cell lung cancer and head and neck squamous cell carcinoma
    Marlon C. Rebelatto, Anita Midha, Amita Mistry, Constantine Sabalos, Nicole Schechter, Xia Li, Xiaoping Jin, Keith E. Steele, Paul B. Robbins, John A. Blake-Haskins, Jill Walker
    Diagnostic Pathology.2016;[Epub]     CrossRef
  • Current clinical immunotherapeutic approaches for head and neck cancer
    Carolina Soto Chervin, Bruce Brockstein
    F1000Research.2016; 5: 803.     CrossRef
  • PD-L1 expression in tonsillar cancer is associated with human papillomavirus positivity and improved survival: implications for anti-PD1 clinical trials
    Angela M Hong, Ricardo E Vilain, Sarah Romanes, Jean Yang, Elizabeth Smith, Deanna Jones, Richard A Scolyer, C Soon Lee, Mei Zhang, Barbara Rose
    Oncotarget.2016; 7(47): 77010.     CrossRef
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Tumor Volume Reduction Rate during Adaptive Radiation Therapy as a Prognosticator for Nasopharyngeal Cancer
Hyebin Lee, Yong Chan Ahn, Dongryul Oh, Heerim Nam, Jae Myoung Noh, Su Yeon Park
Cancer Res Treat. 2016;48(2):537-545.   Published online July 14, 2015
DOI: https://doi.org/10.4143/crt.2015.081
AbstractAbstract PDFPubReaderePub
Purpose
The purpose of this study is to evaluate the prognostic significance of the tumor volume reduction rate (TVRR) measured during adaptive definitive radiation therapy (RT) for nasopharyngeal cancer (NPC).
Materials and Methods
We reviewed the RT records of 159 NPC patients treated with definitive RT with or without concurrent chemotherapy between January 2006 and February 2013. Adaptive re-planning was performed in all patients at the third week of RT. The pre- and mid-RT gross tumor volumes (GTVs) of the primary tumor and the metastatic lymph nodes were measured and analyzed for prognostic implications.
Results
After a median follow-up period of 41.5 months (range, 11.2 to 91.8 months) for survivors, there were 43 treatment failures. The overall survival and progression-free survival (PFS) rates at 5 years were 89.6% and 69.7%, respectively. The mean pre-RT GTV, mid-RT GTV, and TVRR were 45.9 cm3 (range, 1.5 to 185.3 cm3), 26.7 cm3 (1.0 to 113.8 cm3), and –41.9% (range, –87% to 78%), respectively. Patients without recurrence had higher TVRR than those with recurrence (44.3% in the no recurrence group vs. 34.0% in the recurrence group, p=0.004), and those with TVRR > 35% achieved a significantly higher rate of PFS at 5 years (79.2% in TVRR > 35% vs. 53.2% in TVRR ≤ 35%; p < 0.001). In multivariate analysis, TVRR was a significant factor affecting PFS (hazard ratio, 2.877; 95% confidence interval, 1.555 to 5.326; p=0.001).
Conclusion
TVRR proved to be a significant prognostic factor in NPC patients treated with definitive RT, and could be used as a potential indicator for early therapeutic modification during the RT course.

Citations

Citations to this article as recorded by  
  • Risk stratification of LA‐NPC during chemoradiotherapy based on clinical classification and TVRR
    Qianlong Tang, Chaorong Mei, Bei Huang, Rui Huang, Le Kang, Ailin Chen, Na lei, Pengcheng Deng, Shouyan Ying, Peng Zhang, Yuan Qin
    Cancer Medicine.2024;[Epub]     CrossRef
  • Adaptive radiotherapy for head and neck cancer: Pitfalls and possibilities from the radiation oncologist's point of view
    Sandra Nuyts, Heleen Bollen, Avrahram Eisbruch, Primoz Strojan, William M. Mendenhall, Sweet Ping Ng, Alfio Ferlito
    Cancer Medicine.2024;[Epub]     CrossRef
  • Effects of concurrent chemoradiotherapy with or without Endostar on the regression of retropharyngeal lymph node and prognosis of patients with locally advanced nasopharyngeal carcinoma: a retrospective study
    Jun-Mei Song, Ning Mo, Yu-Qing Lv, Lu-Lu Huang, Ya-Jing Wen, Ting Liu, Zhi-Ru Li, Ren-Sheng Wang, Ting-Ting Zhang
    Journal of Cancer Research and Clinical Oncology.2024;[Epub]     CrossRef
  • Current state, challenges, and future perspective of adaptive radiotherapy: A narrative review of nasopharyngeal carcinoma
    Xiate Zhou, Tianchi Shao, Haijian Jia, Liqiao Hou, Xingni Tang, Changhui Yu, Chao Zhou, Suna Zhou, Haihua Yang
    Oral Oncology.2024; 158: 107008.     CrossRef
  • Evaluating psychological anxiety in patients receiving radiation therapy using smartwatch
    Sangwoon Jeong, Chanil Jeon, Dongyeon Lee, Won Park, Hongryull Pyo, Youngyih Han
    Radiation Oncology Journal.2024; 42(2): 148.     CrossRef
  • Dosimetric Comparison and Selection Criteria of Intensity-Modulated Proton Therapy and Intensity-Modulated Radiation Therapy for Adaptive Re-Plan in T3-4 Nasopharynx Cancer Patients
    Mincheol Ko, Kyungmi Yang, Yong Chan Ahn, Sang Gyu Ju, Dongryul Oh, Yeong-bi Kim, Dong Yeol Kwon, Seyjoon Park, Kisung Lee
    Cancers.2024; 16(19): 3402.     CrossRef
  • Tumor volume reduction after induction chemotherapy with gemcitabine plus cisplatin in nasopharyngeal carcinoma
    Qian Chen, Liangfang Shen, Shan Li
    European Archives of Oto-Rhino-Laryngology.2023; 280(5): 2497.     CrossRef
  • Automated tracking of morphologic changes in weekly magnetic resonance imaging during head and neck radiotherapy
    Eric Aliotta, Yu‐Chi Hu, Peng Zhang, Phillip Lichtenwalner, Amanda Caringi, Natasha Allgood, C. Jillian Tsai, Kaveh Zakeri, Nancy Lee, Pengpeng Zhang, Laura Cerviño, Michalis Aristophanous
    Journal of Applied Clinical Medical Physics.2023;[Epub]     CrossRef
  • Nomograms incorporating primary tumor response at mid‐radiotherapy to predict survival in locoregionally advanced nasopharyngeal carcinoma
    Xixi Liu, Jing Huang, You Qin, Zhanjie Zhang, Bian Wu, Kunyu Yang
    Head & Neck.2023; 45(8): 1922.     CrossRef
  • Tumor Volume Reduction Rate to Induction Chemotherapy is a Prognostic Factor for Locally Advanced Head and Neck Squamous Cell Carcinoma: A Retrospective Cohort Study
    Ting-Chun Lin, Chi-Hsien Huang, Ming-Yu Lien, Fu-Ming Cheng, Kai-Chiun Li, Chih-Yuan Lin, Ying-Chun Lin, Ji-An Liang, Ti-Hao Wang
    Technology in Cancer Research & Treatment.2022;[Epub]     CrossRef
  • Assessment of dose gradient index variation during simultaneously integrated boost intensity‐modulated radiation therapy for head and neck cancer patients
    Salam Abdulrazzaq Ibrahim Al‐Rawi, Hassan Abouelenein, Mohamad El‐Sayed EL Nagdy, Haidar Hamza Alabdei, Awf Abdulrahman Sulaiman, Dalya Saad Al‐Nuaimi, Magdy Mohammed Khalil, Ahmed Salih Alshewered
    Precision Radiation Oncology.2022; 6(3): 216.     CrossRef
  • Clinical features of post-radiation nasopharyngeal necrosis and their outcomes following surgical intervention in nasopharyngeal cancer patients
    Kyungmi Yang, Yong Chan Ahn, Heerim Nam, Sang Duk Hong, Dongryul Oh, Jae Myoung Noh
    Oral Oncology.2021; 114: 105180.     CrossRef
  • Early Clinical Outcomes of Intensity Modulated Radiation Therapy/Intensity Modulated Proton Therapy Combination in Comparison with Intensity Modulated Radiation Therapy Alone in Oropharynx Cancer Patients
    Han Gyul Yoon, Yong Chan Ahn, Dongryul Oh, Jae Myoung Noh, Seung Gyu Park, Heerim Nam, Sang Gyu Ju, Dongyeol Kwon, Seyjoon Park
    Cancers.2021; 13(7): 1549.     CrossRef
  • Semi-Automatic Volumetric and Standard Three-Dimensional Measurements for Primary Tumor Evaluation and Response to Treatment Assessment in Pediatric Rhabdomyosarcoma
    Ewelina Gowin, Katarzyna Jończyk-Potoczna, Patrycja Sosnowska-Sienkiewicz, Anna Belen Larque, Paweł Kurzawa, Danuta Januszkiewicz-Lewandowska
    Journal of Personalized Medicine.2021; 11(8): 717.     CrossRef
  • Residual Volume of Lymph Nodes During Chemoradiotherapy Based Nomogram to Predict Survival of Nasopharyngeal Carcinoma Patient Receiving Induction Chemotherapy
    Yan Li, Jian Zang, Jingyi Liu, Shanquan Luo, Jianhua Wang, Bingxin Hou, Lina Zhao, Mei Shi
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Adaptive radiotherapy for head and neck cancer
    Howard E. Morgan, David J. Sher
    Cancers of the Head & Neck.2020;[Epub]     CrossRef
  • Prognostic value of the tumor volume reduction rate after neoadjuvant chemotherapy in patients with locoregional advanced nasopharyngeal carcinoma
    Huiyun Yang, Yuanyuan Liu, Rongjun Zhang, Yaomin Ye, Qiuqiu Chen, Qinghua Qin, Liying Huang, Xi Li, Rui Cai, Huaying Tang, Wei Jiang
    Oral Oncology.2020; 110: 104897.     CrossRef
  • The comparison of prognostic value of tumour volumetric regression ratio and RECIST 1.1 criteria after induction chemotherapy in locoregionally advanced nasopharyngeal carcinoma
    Yuan-Yuan Zeng, Zhong-Zheng Xiang, Tao He, Fang Liu, Bian-Fei Shao, Ruo-Nan Yan, Jia-Chun Ma, Xi-Ran Wang, Lei Liu
    Oral Oncology.2020; 111: 104924.     CrossRef
  • Prognostication of Half-Life Clearance of Plasma EBV DNA in Previously Untreated Non-metastatic Nasopharyngeal Carcinoma Treated With Radical Intensity-Modulated Radiation Therapy
    Sik-Kwan Chan, Sum-Yin Chan, Horace Cheuk-Wai Choi, Chi-Chung Tong, Ka-On Lam, Dora Lai-Wan Kwong, Varut Vardhanabhuti, To-Wai Leung, Mai-Yee Luk, Anne Wing-Mui Lee, Victor Ho-Fun Lee
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Predictive Model and Precaution for Oral Mucositis During Chemo-Radiotherapy in Nasopharyngeal Carcinoma Patients
    Pei-Jing Li, Kai-Xin Li, Ting Jin, Hua-Ming Lin, Jia-Ben Fang, Shuang-Yan Yang, Wei Shen, Jia Chen, Jiang Zhang, Xiao-Zhong Chen, Ming Chen, Yuan-Yuan Chen
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Radiotherapy for Head and Neck Cancer: Evaluation of Triggered Adaptive Replanning in Routine Practice
    Metin Figen, Didem Çolpan Öksüz, Evrim Duman, Robin Prestwich, Karen Dyker, Kate Cardale, Satiavani Ramasamy, Patrick Murray, Mehmet Şen
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • The prognostic value of volumetric reduction of the target lesions after induction chemotherapy in locoregionally advanced nasopharyngeal carcinoma
    Zhong‐zheng Xiang, Fang Liu, Ruo‐nan Yan, Yuan‐yuan Zeng, Tao He, Zhen Zeng, Zhi‐hui Zhu, Long Bai, Jia‐chun Ma, Lei Liu
    Head & Neck.2019; 41(6): 1863.     CrossRef
  • Less is more: role of additional chemotherapy to concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal cancer management
    Yong Chan Ahn
    Radiation Oncology Journal.2019; 37(2): 67.     CrossRef
  • Early clinical outcomes of helical tomotherapy/intensity‐modulated proton therapy combination in nasopharynx cancer
    Seung Gyu Park, Yong Chan Ahn, Dongryul Oh, Jae Myoung Noh, Sang Gyu Ju, Dongyeol Kwon, Kwanghyun Jo, Kwangzoo Chung, Eunah Chung, Woojin Lee, Seyjoon Park
    Cancer Science.2019; 110(9): 2867.     CrossRef
  • Pretreatment Prediction of Adaptive Radiation Therapy Eligibility Using MRI-Based Radiomics for Advanced Nasopharyngeal Carcinoma Patients
    Ting-ting Yu, Sai-kit Lam, Lok-hang To, Ka-yan Tse, Nong-yi Cheng, Yeuk-nam Fan, Cheuk-lai Lo, Ka-wa Or, Man-lok Chan, Ka-ching Hui, Fong-chi Chan, Wai-ming Hui, Lo-kin Ngai, Francis Kar-ho Lee, Kwok-hung Au, Celia Wai-yi Yip, Yong Zhang, Jing Cai
    Frontiers in Oncology.2019;[Epub]     CrossRef
  • Which nasopharyngeal cancer patients need adaptive radiotherapy?
    Yu-Chang Hu, Kuo-Wang Tsai, Ching-Chih Lee, Nan-Jing Peng, Ju-Chun Chien, Hsin-Hui Tseng, Po-Chun Chen, Jin-Ching Lin, Wen-Shan Liu
    BMC Cancer.2018;[Epub]     CrossRef
  • 13,019 View
  • 148 Download
  • 28 Web of Science
  • 26 Crossref
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Efficacy of Imatinib in Patients with Platelet-Derived Growth Factor Receptor Alpha–Mutated Gastrointestinal Stromal Tumors
Changhoon Yoo, Min-Hee Ryu, Jungmin Jo, Inkeun Park, Baek-Yeol Ryoo, Yoon-Koo Kang
Cancer Res Treat. 2016;48(2):546-552.   Published online June 22, 2015
DOI: https://doi.org/10.4143/crt.2015.015
AbstractAbstract PDFPubReaderePub
Purpose
The incidence of gastrointestinal stromal tumors (GISTs) harboring platelet-derived growth factor receptor alpha (PDGFRA) mutations is low, therefore further investigation of the efficacy of imatinib in this subgroup was needed.
Materials and Methods
Patients with PDGFRA-mutant GISTs who received imatinib as primary therapy for advanced disease between January 2000 and June 2012 were identified from the GIST registry of Asan Medical Center, Seoul, Korea.
Results
KIT and PDGFRA genotyping in 823 patients identified 18 patients (2%) with PDGFRA mutations who were treated with first-line imatinib. Exon 18 D842V substitution, non-D842V exon 18 mutations, and exon 12 mutations were detected in nine (50%), four (22%), and five (28%) patients, respectively. Objective response rate differed significantly between patients with the D842V mutation and those with non-D842V mutations (0% [0/5] vs. 71% [5/7], p=0.03). In all patients, median progression-free survival (PFS) and overall survival (OS) was 24.8 months (95% confidence interval [CI], 0.0 to 57.2) and 51.2 months (95% CI, 37.1 to 65.3), respectively. Significantly, poorer PFS was observed for patients with D842V-mutant GISTs than those with non-D842V PDGFRA-mutant GISTs: median 3.8 months (95% CI, 1.4 to 6.3) versus 29.5 months (95% CI, 18.3 to 40.7) (p < 0.001). Patients with the D842V mutation had poorer OS than those with non-D842V PDGFRA mutations: median 25.2 months (95% CI, 12.7 to 37.8) versus 59.8 months (95% CI, 43.0 to 76.5) (p=0.02).
Conclusion
Imatinib is active against non-D842V PDGFRA-mutant GISTs, whereas GISTs harboring the D842V mutation are primarily resistant to imatinib.

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  • Imatinib adherence prediction using machine learning approach in patients with gastrointestinal stromal tumor
    Li Liu, Ze Yu, Hefen Chen, Zhujun Gong, Xiao Huang, Linhua Chen, Ziying Fan, Jinyuan Zhang, Jiannan Yan, Hongkun Tian, Xiangyu Zeng, Zhiliang Chen, Peng Zhang, Hong Zhou
    Cancer.2025;[Epub]     CrossRef
  • Clinical implementation of next-generation sequencing testing and genomically-matched therapy: a real-world data in a tertiary hospital
    Jin Won Kim, Hee Young Na, Sejoon Lee, Ji-Won Kim, Koung Jin Suh, Se Hyun Kim, Yu Jung Kim, Keun-Wook Lee, Jong Seok Lee, Jaihwan Kim, Jin-Hyeok Hwang, Kihwan Hwang, Chae-Yong Kim, Yong Beom Kim, Soomin Ahn, Kyu Sang Lee, Hyojin Kim, Hye Seung Lee, So Yeo
    Scientific Reports.2025;[Epub]     CrossRef
  • 18F-Fluorodeoxyglucose Uptake in PDGFRA-Mutant Gastrointestinal Stromal Tumors
    Maria Concetta Nigro, Andrea Marchetti, Elena Rosa Fumagalli, Ida De Luca, Alexia Francesca Bertuzzi, Maria Susanna Grimaudo, Giovanni Grignani, Lorenzo D’Ambrosio, Alessandra Merlini, Giuseppe Badalamenti, Lorena Incorvaia, Alessandra Dimino, Silvia Gasp
    JAMA Network Open.2025; 8(1): e2456058.     CrossRef
  • Ripretinib versus sunitinib in gastrointestinal stromal tumor: ctDNA biomarker analysis of the phase 3 INTRIGUE trial
    Michael C. Heinrich, Robin L. Jones, Suzanne George, Hans Gelderblom, Patrick Schöffski, Margaret von Mehren, John R. Zalcberg, Yoon-Koo Kang, Albiruni Abdul Razak, Jonathan Trent, Steven Attia, Axel Le Cesne, Brittany L. Siontis, David Goldstein, Kjetil
    Nature Medicine.2024; 30(2): 498.     CrossRef
  • English version of Japanese Clinical Practice Guidelines 2022 for gastrointestinal stromal tumor (GIST) issued by the Japan Society of Clinical Oncology
    Seiichi Hirota, Ukihide Tateishi, Yuji Nakamoto, Hidetaka Yamamoto, Shinji Sakurai, Hirotoshi Kikuchi, Tatsuo Kanda, Yukinori Kurokawa, Haruhiko Cho, Toshirou Nishida, Akira Sawaki, Masato Ozaka, Yoshito Komatsu, Yoichi Naito, Yoshitaka Honma, Fumiaki Tak
    International Journal of Clinical Oncology.2024; 29(6): 647.     CrossRef
  • Establishing biomarkers for soft tissue sarcomas
    Anna M. Czarnecka, Paulina Chmiel, Piotr Błoński, Piotr Rutkowski
    Expert Review of Anticancer Therapy.2024; 24(6): 407.     CrossRef
  • First Description of the Clinical Activity of Avapritinib in Sporadic Mesenteric Desmoid Tumor
    Rebecca Ganzon, Wei Chen, Gabriel Tinoco, Jose I. Mayordomo
    Case Reports in Oncological Medicine.2024;[Epub]     CrossRef
  • Therapeutic advances of targeting receptor tyrosine kinases in cancer
    Ciprian Tomuleasa, Adrian-Bogdan Tigu, Raluca Munteanu, Cristian-Silviu Moldovan, David Kegyes, Anca Onaciu, Diana Gulei, Gabriel Ghiaur, Hermann Einsele, Carlo M. Croce
    Signal Transduction and Targeted Therapy.2024;[Epub]     CrossRef
  • Current Drug Resistance Mechanisms and Treatment Options in Gastrointestinal Stromal Tumors: Summary and Update
    Chunxiao He, Zilong Wang, Jiaying Yu, Shuang Mao, Xi Xiang
    Current Treatment Options in Oncology.2024; 25(11): 1390.     CrossRef
  • Personalized and targeted therapies
    Magdalena Wiśniewska, Michał Wiśniewski, Marzena A. Lewandowska
    Physical Sciences Reviews.2023; 8(9): 2103.     CrossRef
  • Molecular Mechanisms of Gastrointestinal Stromal Tumors and Their Impact on Systemic Therapy Decision
    Mojca Unk, Barbara Jezeršek Novaković, Srdjan Novaković
    Cancers.2023; 15(5): 1498.     CrossRef
  • Precision Oncology in Gastrointestinal Stromal Tumors
    Hiba Mechahougui, Montemurro Michael, Alex Friedlaender
    Current Oncology.2023; 30(5): 4648.     CrossRef
  • Molecular Advances in the Treatment of Advanced Gastrointestinal Stromal Tumor
    Vinayak Venkataraman, Suzanne George, Gregory M Cote
    The Oncologist.2023; 28(8): 671.     CrossRef
  • Evaluation of Systemic Treatment Options for Gastrointestinal Stromal Tumours
    Marin Golčić, Robin L. Jones, Paul Huang, Andrea Napolitano
    Cancers.2023; 15(16): 4081.     CrossRef
  • Neoadjuvant Imatinib in Locally Advanced Gastrointestinal Stromal Tumors (GISTs) is Effective and Safe: Results from a Prospective Single-Center Study with 108 Patients
    Stijn J. C. van der Burg, Deborah van de Wal, Evelyne Roets, Neeltje Steeghs, Johanna W. van Sandick, Martijn Kerst, Frits van Coevorden, Koen J. Hartemink, Xander A. A. F. A. Veenhof, Anne Miek Koenen, Nikki Ijzerman, Winette T. A. van der Graaf, Yvonne
    Annals of Surgical Oncology.2023; 30(13): 8660.     CrossRef
  • New treatment strategies for advanced-stage gastrointestinal stromal tumours
    Lillian R. Klug, Homma M. Khosroyani, Jason D. Kent, Michael C. Heinrich
    Nature Reviews Clinical Oncology.2022; 19(5): 328.     CrossRef
  • Clinicopathologic Characteristics and Prognosis of PDGFRA-Mutant Gastrointestinal Stromal Tumors: A Large-Scale, Multi-Institutional, Observational Study in China
    Peng Zhang, Ming Wang, Jian Li, Xiaodong Gao, Bo Zhang, Han Liang, Ye Zhou, Guoqing Liao, Fan Feng, Yanbing Zhou, Jiren Yu, Jun Zhang, Yongjian Zhou, Yingjiang Ye, Jiansi Chen, Qun Zhao, Kuntang Shen, Hui Cao, Kaixiong Tao
    Advances in Therapy.2022; 39(6): 2920.     CrossRef
  • ACR Appropriateness Criteria® Staging of Colorectal Cancer: 2021 Update
    Elena K. Korngold, Courtney Moreno, David H. Kim, Kathryn J. Fowler, Brooks D. Cash, Kevin J. Chang, Kenneth L. Gage, Aakash H. Gajjar, Evelyn M. Garcia, Avinash R. Kambadakone, Peter S. Liu, Meghan Macomber, Daniele Marin, Jason A. Pietryga, Cynthia S. S
    Journal of the American College of Radiology.2022; 19(5): S208.     CrossRef
  • Gastrointestinal stromal tumors caused by novel germline variants in SDHB and KIT: a report of two cases and literature review
    Sean Rasmussen, Ashley Stueck, Bruce Colwell, Daniel Gaston, Michael Carter
    Clinical Journal of Gastroenterology.2022; 15(5): 869.     CrossRef
  • An overview of agents and treatments for PDGFRA-mutated gastrointestinal stromal tumors
    Yingchao Sun, Lei Yue, Pengfu Xu, Weiling Hu
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • A literature review and database of how the primary KIT/PDGFRA variant of a gastrointestinal stromal tumour predicts for sensitivity to imatinib
    Newton A.C.S. Wong, Christel Garcia-Petit, Adam Dangoor, Nicola Andrew
    Cancer Genetics.2022; 268-269: 46.     CrossRef
  • Correlation of treatment outcome in sanger/RT‑qPCR KIT/PDGFRA wild‑type metastatic gastrointestinal stromal tumors with next‑generation sequencing results: A single‑center report
    Mojca Unk, Alenka Bombač, Barbara Jezeršek Novaković, Vida Stegel, Vita Šetrajčič, Olga Blatnik, Gašper Klančar, Srdjan Novaković
    Oncology Reports.2022;[Epub]     CrossRef
  • Optimal Avapritinib Treatment Strategies for Patients with Metastatic or Unresectable Gastrointestinal Stromal Tumors
    Cissimol P. Joseph, Sarah N. Abaricia, Michelle A. Angelis, Kathleen Polson, Robin L. Jones, Yoon-Koo Kang, Richard F. Riedel, Patrick Schöffski, César Serrano, Jonathan Trent, Eric D. Tetzlaff, Tuan Dong Si, Teresa Zhou, Ashley Doyle, Sebastian Bauer, Ma
    The Oncologist.2021; 26(4): e622.     CrossRef
  • Avapritinib in unresectable or metastatic PDGFRA D842V-mutant gastrointestinal stromal tumours: Long-term efficacy and safety data from the NAVIGATOR phase I trial
    Robin L. Jones, César Serrano, Margaret von Mehren, Suzanne George, Michael C. Heinrich, Yoon-Koo Kang, Patrick Schöffski, Philippe A. Cassier, Olivier Mir, Sant P. Chawla, Ferry A.L.M. Eskens, Piotr Rutkowski, William D. Tap, Teresa Zhou, Maria Roche, Se
    European Journal of Cancer.2021; 145: 132.     CrossRef
  • Prognostic and predictive values of the KIT11-mutated grading system in patients with gastrointestinal stromal tumors: a retrospective study
    Ling-Jun Song, Hui-Juan Ge, Xiao-Qin Shi, Wei-Wei Shen
    Human Pathology.2021; 110: 31.     CrossRef
  • The Identity of PDGFRA D842V-Mutant Gastrointestinal Stromal Tumors (GIST)
    Alessandro Rizzo, Maria Abbondanza Pantaleo, Annalisa Astolfi, Valentina Indio, Margherita Nannini
    Cancers.2021; 13(4): 705.     CrossRef
  • Clinical efficacy comparison of avapritinib with other tyrosine kinase inhibitors in gastrointestinal stromal tumors with PDGFRA D842V mutation: a retrospective analysis of clinical trial and real-world data
    Margaret von Mehren, Michael C. Heinrich, Hongliang Shi, Sergio Iannazzo, Raymond Mankoski, Saša Dimitrijević, Gerard Hoehn, Silvia Chiroli, Suzanne George
    BMC Cancer.2021;[Epub]     CrossRef
  • Stellungnahme der AIO, DGHO und DGVS zur Nutzenbewertung von Avapritinib bei gastrointestinalen Stromatumoren (GIST)

    Zeitschrift für Gastroenterologie.2021; 59(04): 366.     CrossRef
  • Nationwide evaluation of mutation-tailored treatment of gastrointestinal stromal tumors in daily clinical practice
    Elisabeth M. P. Steeghs, Hans Gelderblom, Vincent K. Y. Ho, Quirinus J. M. Voorham, Stefan M. Willems, Katrien Grünberg, Marjolijn J. L. Ligtenberg
    Gastric Cancer.2021; 24(5): 990.     CrossRef
  • New FDA oncology small molecule drugs approvals in 2020: Mechanism of action and clinical applications
    Thais Cristina Mendonça Nogueira, Marcus Vinicius Nora de Souza
    Bioorganic & Medicinal Chemistry.2021; 46: 116340.     CrossRef
  • Avapritinib in Advanced Gastrointestinal Stromal Tumor: Case Series and Review of the Literature From a Tertiary Care Center in India
    Saurav Verma, Rohit Reddy, Sheragaru Hanumanthappa Chandrashekhara, Shamim Ahmed Shamim, Sarthak Tripathy, Sameer Rastogi
    Future Science OA.2021;[Epub]     CrossRef
  • Mutations of the c-Kit and PDGFRA Gene in Gastrointestinal Stromal Tumors among Hakka Population of Southern China
    S Wang, Q Zhang, H Wu, Z Yang, X Guo, F Wang, Z Yu, Z Zhong
    Nigerian Journal of Clinical Practice.2021; 24(6): 814.     CrossRef
  • Gene Expression Profiling of PDGFRA Mutant GIST Reveals Immune Signatures as a Specific Fingerprint of D842V Exon 18 Mutation
    Valentina Indio, Gloria Ravegnini, Annalisa Astolfi, Milena Urbini, Maristella Saponara, Antonio De Leo, Elisa Gruppioni, Giuseppe Tarantino, Sabrina Angelini, Andrea Pession, Maria Abbondanza Pantaleo, Margherita Nannini
    Frontiers in Immunology.2020;[Epub]     CrossRef
  • Avapritinib in advanced PDGFRA D842V-mutant gastrointestinal stromal tumour (NAVIGATOR): a multicentre, open-label, phase 1 trial
    Michael C Heinrich, Robin L Jones, Margaret von Mehren, Patrick Schöffski, César Serrano, Yoon-Koo Kang, Philippe A Cassier, Olivier Mir, Ferry Eskens, William D Tap, Piotr Rutkowski, Sant P Chawla, Jonathan Trent, Meera Tugnait, Erica K Evans, Tamieka La
    The Lancet Oncology.2020; 21(7): 935.     CrossRef
  • Adult Jejuno-Jejunal Intussusceptions due to Gastrointestinal Stromal Tumor
    Jayabal Pandiaraja
    Indian Journal of Medical and Paediatric Oncology.2020; 41(04): 602.     CrossRef
  • Molecular modelling evaluation of exon 18 His845_Asn848delinsPro PDGFRα mutation in a metastatic GIST patient responding to imatinib
    Margherita Nannini, Giuseppe Tarantino, Valentina Indio, Gloria Ravegnini, Annalisa Astolfi, Milena Urbini, Antonio De Leo, Donatella Santini, Claudio Ceccarelli, Elisa Gruppioni, Annalisa Altimari, Paolo Castellucci, Stefano Fanti, Valerio Di Scioscio, M
    Scientific Reports.2019;[Epub]     CrossRef
  • Clinical relevance of molecular diagnostics in gastrointestinal (GI) cancer: European Society of Digestive Oncology (ESDO) expert discussion and recommendations from the 17th European Society for Medical Oncology (ESMO)/World Congress on Gastrointestinal
    Alexander Baraniskin, Jean-Luc Van Laethem, Lucjan Wyrwicz, Ulrich Guller, Harpreet S. Wasan, Tamara Matysiak-Budnik, Thomas Gruenberger, Michel Ducreux, Fatima Carneiro, Eric Van Cutsem, Thomas Seufferlein, Wolff Schmiegel
    European Journal of Cancer.2017; 86: 305.     CrossRef
  • A precision therapy against cancers driven by KIT/PDGFRA mutations
    Erica K. Evans, Alexandra K. Gardino, Joseph L. Kim, Brian L. Hodous, Adam Shutes, Alison Davis, Xing Julia Zhu, Oleg Schmidt-Kittler, Doug Wilson, Kevin Wilson, Lucian DiPietro, Yulian Zhang, Natasja Brooijmans, Timothy P. LaBranche, Agnieszka Wozniak, Y
    Science Translational Medicine.2017;[Epub]     CrossRef
  • Tyrosine kinase inhibitor sensitive PDGFRΑ mutations in GIST: Two cases and review of the literature
    Pieter A. Boonstra, Jourik A. Gietema, Albert J.H. Suurmeijer, Matthew R. Groves, Fernando de Assis Batista, Ed Schuuring, Anna K.L. Reyners
    Oncotarget.2017; 8(65): 109836.     CrossRef
  • Molecular subtypes of gastrointestinal stromal tumor requiring specific treatments
    Michael Pogorzelski, Johanna Falkenhorst, Sebastian Bauer
    Current Opinion in Oncology.2016; 28(4): 331.     CrossRef
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A Retrospective Analysis for Patients with HER2-Positive Gastric Cancer Who Were Treated with Trastuzumab-Based Chemotherapy: In the Perspectives of Ethnicity and Histology
Jun Ho Yi, Jung Hun Kang, In Gyu Hwang, Hee Kyung Ahn, Hyun Jin Baek, Soon Il Lee, Do Hyoung Lim, Young-Woong Won, Jun Ho Ji, Hyo Song Kim, Sun Young Rha, Sung Yong Oh, Kyung Eun Lee, Taekyu Lim, Chi Hoon Maeng, Moon Jin Kim, Seung Tae Kim, Jeeyun Lee, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang, Se Hoon Park
Cancer Res Treat. 2016;48(2):553-560.   Published online August 10, 2015
DOI: https://doi.org/10.4143/crt.2015.155
AbstractAbstract PDFPubReaderePub
Purpose
While the Trastuzumab for Gastric Cancer (ToGA) trial demonstrated the efficacy and safety of trastuzumab-based chemotherapy in HER2-positive metastatic gastric cancer, the overall survival (OS) benefit was not found in Asian and diffuse-type cancer patients. The aim of the study is to investigate predictive markers for trastuzumab-based chemotherapy.
Materials and Methods
Data of patients with HER2-positive gastric cancer treated with trastuzumab-based chemotherapy were analyzed retrospectively.
Results
A total of 168 Asian patients were included. The median age was 60 years (range, 27 to 85 years) and the male:female ratio was 118 (70.2%):50 (29.8%). Fourteen (8.3%), 63 (37.5%), 75 (44.6%), and 11 (6.5%) patients had well, moderately, poorly-differentiated tubular adenocarcinoma and signet ring cell carcinoma, respectively. With 14 complete responses and 73 partial responses, the response rate was 50.6%. The median progression-free survival (PFS) was 10.2 months (95% confidence interval [CI], 8.7 to 11.7), and the median OS was 18.5 months (95% CI, 16.4 to 50.6). Next, we investigated the effect of poorly-differentiated histology (PDH, poorly-differentiated tubular adenocarcinoma+signet ring cell carcinoma) on clinical outcomes. The median PFS (8.9 months vs. 11.5 months, p=0.16) was slightly inferior in PDH patients, and the median OS was significantly shorter in PDH patients (14.6 months vs. 19.0 months, p=0.025).
Conclusion
While subset analysis of the ToGA trial demonstrated that trastuzumab-based chemotherapy may not be beneficial for Asians and patients with PDH, our data may suggest that even in Asian patients and patients with PDH, trastuzumab-based chemotherapy could be associated with improved clinical outcomes in patients with HER2-positive gastric cancer.

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  • Timing to Surgery and Lymph Node Upstaging in Gastric Cancer: An NCDB Analysis
    Maria Cristina Riascos, Jacques A. Greenberg, Federico Palacardo, Rodrigo Edelmuth, V. Colby Lewis, Anjile An, Haythem Najah, Hala Al Asadi, Parima Safe, Brendan M. Finnerty, Paul J. Christos, Thomas J. Fahey, Rasa Zarnegar
    Annals of Surgical Oncology.2024; 31(3): 1714.     CrossRef
  • Deviating HER2 test results in gastric cancer: analysis from the prospective multicenter VARIANZ study
    Katharina Kolbe, Ivonne Haffner, Katrin Schierle, Dieter Maier, Birgitta Geier, Birgit Luber, Hendrik Bläker, Christian Wittekind, Florian Lordick
    Journal of Cancer Research and Clinical Oncology.2023; 149(3): 1319.     CrossRef
  • Trastuzumab Combined With Ramucirumab and Paclitaxel in Patients With Previously Treated Human Epidermal Growth Factor Receptor 2–Positive Advanced Gastric or Gastroesophageal Junction Cancer
    Chang Gon Kim, Minkyu Jung, Hyo Song Kim, Choong-kun Lee, Hei-Cheul Jeung, Dong-Hoe Koo, Woo Kyun Bae, Dae Young Zang, Bum Jun Kim, Hyunki Kim, Un-Jung Yun, Jingmin Che, Sejung Park, Tae Soo Kim, Woo Sun Kwon, Juin Park, Sang Woo Cho, Chung Mo Nam, Hyun C
    Journal of Clinical Oncology.2023; 41(27): 4394.     CrossRef
  • Novel HER2-targeted therapy to overcome trastuzumab resistance in HER2-amplified gastric cancer
    Juin Park, Sun Kyoung Kang, Woo Sun Kwon, Inhye Jeong, Tae Soo Kim, Seo Young Yu, Sang Woo Cho, Hyun Cheol Chung, Sun Young Rha
    Scientific Reports.2023;[Epub]     CrossRef
  • Do proton pump inhibitors affect the effectiveness of chemotherapy in colorectal cancer patients? A systematic review with meta-analysis
    Wan-Ying Lin, Shih-Syuan Wang, Yi-No Kang, Andrea S. Porpiglia, Yu Chang, Chin-Hsuan Huang, Ronak Bhimani, Eahab Abdul-Lattif, Muneeba Azmat, Tsu-Hsien Wang, Yu-Shiuan Lin, Yu-Cheng Chang, Kuan-Yu Chi
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Effectiveness of Trastuzumab in Routine Clinical Practice: A Population-based Study of Patients with HER-2-positive Oesophageal, Gastroesophageal and Gastric Cancer
    S.J. Merchant, W. Kong, B. Gyawali, T. Hanna, W. Chung, S. Nanji, S.V. Patel, C.M. Booth
    Clinical Oncology.2021; 33(3): 202.     CrossRef
  • Trastuzumab-based palliative chemotherapy for HER2-positive gastric cancer: a single-center real-world data
    Tae-Hwan Kim, Hun Do Cho, Yong Won Choi, Hyun Woo Lee, Seok Yun Kang, Geum Sook Jeong, Jin-Hyuk Choi, Mi Sun Ahn, Seung-Soo Sheen
    BMC Cancer.2021;[Epub]     CrossRef
  • HER2 Expression, Test Deviations, and Their Impact on Survival in Metastatic Gastric Cancer: Results From the Prospective Multicenter VARIANZ Study
    Ivonne Haffner, Katrin Schierle, Elba Raimúndez, Birgitta Geier, Dieter Maier, Jan Hasenauer, Birgit Luber, Axel Walch, Katharina Kolbe, Jorge Riera Knorrenschild, Albrecht Kretzschmar, Beate Rau, Ludwig Fischer von Weikersthal, Miriam Ahlborn, Gabriele S
    Journal of Clinical Oncology.2021; 39(13): 1468.     CrossRef
  • Current therapeutic options for gastric adenocarcinoma
    C.R. Akshatha, Smitha Bhat, R. Sindhu, Dharini Shashank, Sarana Rose Sommano, Wanaporn Tapingkae, Ratchadawan Cheewangkoon, Shashanka K. Prasad
    Saudi Journal of Biological Sciences.2021; 28(9): 5371.     CrossRef
  • Efficacy of Trastuzumab and Potential Risk Factors on Survival in Patients with HER2-Positive Metastatic Gastric Cancer
    Atakan Topcu, Muhammed Mustafa Atci, Saban Secmeler, Mehmet Besiroglu, Murat Ayhan, Metin Ozkan, Oktay Bozkurt, Zuhat Urakci, Seval Ay, Caglayan Geredeli, Ayse Irem Yasin, Haci Mehmet Turk
    Future Oncology.2021; 17(31): 4157.     CrossRef
  • Reliability of Conclusions from Early Analyses of Real-World Data for Newly Approved Drugs in Advanced Gastric Cancer in the United States


    Lisa M Hess, Michael Grabner, Liya Wang, Astra M Liepa, Xiaohong Ivy Li, Zhanglin Lin Cui, Lee Bowman, William R Schelman
    Pragmatic and Observational Research.2020; Volume 11: 27.     CrossRef
  • Targeting HER2-positive gastric cancer with a novel 18F-labeled ZHER2:342 probe
    Yunyun Pan, Zhengyang Yang, Yuping Xu, Zhicheng Bai, Donghui Pan, Runlin Yang, Lizhen Wang, Wenxian Guan, Min Yang
    RSC Advances.2019; 9(19): 10990.     CrossRef
  • Clinical significance of overexpression of NRG1 and its receptors, HER3 and HER4, in gastric cancer patients
    Sumi Yun, Jiwon Koh, Soo Kyung Nam, Jung Ok Park, Sung Mi Lee, Kyoungyul Lee, Kyu Sang Lee, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Gheeyoung Choe, Woo Ho Kim, Hye Seung Lee
    Gastric Cancer.2018; 21(2): 225.     CrossRef
  • Correlation of trastuzumab-based treatment with clinical characteristics and prognosis in HER2-positive gastric and gastroesophageal junction cancer: A retrospective single center analysis
    A. Ilhan-Mutlu, H. Taghizadeh, A. Beer, W. Dolak, A. Ba-Ssalamah, S. F. Schoppmann, M. Hejna, P. Birner, M. Preusser
    Cancer Biology & Therapy.2018; 19(3): 169.     CrossRef
  • Docetaxel, oxaliplatin, 5FU, and trastuzumab as first-line therapy in patients with human epidermal receptor 2-positive advanced gastric or gastroesophageal junction cancer
    Giandomenico Roviello, Roberto Petrioli, Valerio Nardone, Pietro Rosellini, Andrea Giovanni Multari, Raffaele Conca, Michele Aieta
    Medicine.2018; 97(20): e10745.     CrossRef
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Multimodal Assessments Are Needed for Restaging after Neoadjunvant Chemoradiation Therapy in Rectal Cancer Patients
Bong-Hyeon Kye, Hyung-Jin Kim, Gun Kim, Jun-Gi Kim, Hyeon-Min Cho
Cancer Res Treat. 2016;48(2):561-566.   Published online August 10, 2015
DOI: https://doi.org/10.4143/crt.2015.114
AbstractAbstract PDFPubReaderePub
Purpose
Restaging after neoadjuvant treatment is done for planning the surgical approach and, increasingly, to determine whether additional therapy or resection can be avoided for selected patients. Materials and Methods Local restaging after neoadjuvant chemoradiation therapy (nCRT) was performed in 270 patients with locally advanced (cT3or4 or N+) rectal cancer. Abdomen and pelvic computed tomography (APCT) was used in all 270 patients, transrectal ultrasound (TRUS) in 121 patients, and rectal magnetic resonance imaging (MRI) in 65 patients. Findings according to imaging modalities were correlated with pathologic stage using Cohen’s kappa (κ) to test agreement and intra-class correlation coefficient α to test reliability.
Results
Accuracy for prediction of yp T stage according to three imaging modalities was 45.2% (κ=0.136, α=0.380) in APCT, 49.2% (κ=0.259, α=0.514) in rectal MRI, and 57.9% (κ=0.266, α=0.520) in TRUS. Accuracy for prediction of yp N stage was 66.0% (κ=0.274, α=0.441) in APCT, 71.8% (κ=0.401, α=0.549) in rectal MRI, and 66.1% (κ=0.147, α=0.272) in TRUS. Of 270 patients, 37 (13.7%) were diagnosed as pathologic complete responder after nCRT. Rectal MRI for restaging did not predict complete response. On the other hand, TRUS did predict three complete responders (κ=0.238, α=0.401). Conclusion APCT, rectal MRI, and TRUS are unreliable in restaging rectal cancer after nCRT. We think that multimodal assessment with rectal MRI and TRUS may be the best option for local restaging of locally advanced rectal cancer after nCRT.

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  • Response Assessment after Neoadjuvant Chemoradiotherapy in Rectal Cancer
    Anuradha Chandramohan, Antony Augustine, Sneha Hiriyanna, Shobiga Natarajan, Ajeet A. Selvam, Kurian C. Eapen, Saloni A. Yadav, Joseph Chacko Paul, Aisha Lakhani, Betty Simon, Anu Eapen
    Journal of Gastrointestinal and Abdominal Radiology.2025;[Epub]     CrossRef
  • Effect of neoadjuvant therapy regimens on lymph nodes yield in rectal cancer
    Emeka Ray‐Offor, Arun Nagarajan, Nir Horesh, Sameh H. Emile, Rachel Gefen, Zoe Garoufalia, Justin Dourado, Albert Parlade, Giovanna Da Silva, Steven Wexner
    Journal of Surgical Oncology.2024; 130(1): 125.     CrossRef
  • The predicting value of post neoadjuvant treatment magnetic resonance imaging: a meta-analysis
    Yaniv Zager, Nir Horesh, Michael Abdelmasseh, Christopher T. Aquina, Bustamante Lopez Leonardo Alfonso, Mark K. Soliman, Matthew R. Albert, John R. T. Monson
    Surgical Endoscopy.2024; 38(11): 6846.     CrossRef
  • Restaging rectal cancer following neoadjuvant chemoradiotherapy
    Dajana Cuicchi, Giovanni Castagna, Stefano Cardelli, Cristina Larotonda, Benedetta Petrello, Gilberto Poggioli
    World Journal of Gastrointestinal Oncology.2023; 15(5): 700.     CrossRef
  • How reliable is restaging MRI after neoadjuvant therapy in rectal cancer?
    Rachel Gefen, Zoe Garoufalia, Nir Horesh, Michael R. Freund, Sameh Hany Emile, Albert Parlade, Mariana Berho, Daniela Allende, Giovanna DaSilva, Steven D. Wexner
    Colorectal Disease.2023; 25(8): 1631.     CrossRef
  • Can rectal MRI and endorectal ultrasound accurately predict the complete response to neoadjuvant immunotherapy for rectal cancer?
    Menglan Zhai, Zhenyu Lin, Haihong Wang, Jinru Yang, Mingjie Li, Xin Li, Lan Zhang, Tao Zhang
    Gastroenterology Report.2023;[Epub]     CrossRef
  • ACR Appropriateness Criteria® Staging of Colorectal Cancer: 2021 Update
    Elena K. Korngold, Courtney Moreno, David H. Kim, Kathryn J. Fowler, Brooks D. Cash, Kevin J. Chang, Kenneth L. Gage, Aakash H. Gajjar, Evelyn M. Garcia, Avinash R. Kambadakone, Peter S. Liu, Meghan Macomber, Daniele Marin, Jason A. Pietryga, Cynthia S. S
    Journal of the American College of Radiology.2022; 19(5): S208.     CrossRef
  • Could early tumour volume changes assessed on morphological MRI predict the response to chemoradiation therapy in locally-advanced rectal cancer?
    A. Palmisano, A. Esposito, A. Di Chiara, A. Ambrosi, P. Passoni, N. Slim, C. Fiorino, L. Albarello, N. Di Muzio, R. Calandrino, R. Rosati, A. Del Maschio, F. De Cobelli
    Clinical Radiology.2018; 73(6): 555.     CrossRef
  • Application value of biplane transrectal ultrasonography plus ultrasonic elastosonography and contrast-enhanced ultrasonography in preoperative T staging after neoadjuvant chemoradiotherapy for rectal cancer
    Ying Xiao, Dong Xu, Haixing Ju, Chen Yang, Liping Wang, Jinming Wang, John D. Hazle, Dongguo Wang
    European Journal of Radiology.2018; 104: 20.     CrossRef
  • Magnetic resonance imaging evaluation in neoadjuvant therapy of locally advanced rectal cancer: a systematic review
    Roberta Fusco, Mario Petrillo, Vincenza Granata, Salvatore Filice, Mario Sansone, Orlando Catalano, Antonella Petrillo
    Radiology and Oncology.2017; 51(3): 252.     CrossRef
  • Accuracy of MRI in Restaging Locally Advanced Rectal Cancer After Preoperative Chemoradiation
    Joris J. van den Broek, Floor S. W. van der Wolf, Max J. Lahaye, Luc A. Heijnen, Christof Meischl, Martin A. Heitbrink, W. Hermien Schreurs
    Diseases of the Colon & Rectum.2017; 60(3): 274.     CrossRef
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Endoscopic Criteria for Evaluating Tumor Stage after Preoperative Chemoradiation Therapy in Locally Advanced Rectal Cancer
Kyung Su Han, Dae Kyung Sohn, Dae Yong Kim, Byung Chang Kim, Chang Won Hong, Hee Jin Chang, Sun Young Kim, Ji Yeon Baek, Sung Chan Park, Min Ju Kim, Jae Hwan Oh
Cancer Res Treat. 2016;48(2):567-573.   Published online September 22, 2015
DOI: https://doi.org/10.4143/crt.2015.195
AbstractAbstract PDFPubReaderePub
Purpose
Local excision may be an another option for selected patients with markedly down-staged rectal cancer after preoperative chemoradiation therapy (CRT), and proper evaluation of post-CRT tumor stage (ypT) is essential prior to local excision of these tumors. This study was designed to determine the correlations between endoscopic findings and ypT of rectal cancer.
Materials and Methods
In this study, 481 patients with locally advanced rectal cancer who underwent preoperative CRT followed by surgical resection between 2004 and 2013 at a single institution were evaluated retrospectively. Pathological good response (p-GR) was defined as ypT ≤ 1, and pathological minimal or no response (p-MR) as ypT ≥ 2. The patients were randomly classified according to two groups, a testing (n=193) and a validation (n=288) group. Endoscopic criteria were determined from endoscopic findings and ypT in the testing group and used in classifying patients in the validation group as achieving or not achieving p-GR.
Results
Based on findings in the testing group, the endoscopic criteria for p-GR included scarring, telangiectasia, and erythema, whereas criteria for p-MR included nodules, ulcers, strictures, and remnant tumors. In the validation group, the kappa statistic was 0.965 (p < 0.001), and the sensitivity, specificity, positive predictive value, and negative predictive value were 0.362, 0.963, 0.654, and 0.885, respectively.
Conclusion
The endoscopic criteria presented are easily applicable for evaluation of ypT after preoperative CRT for rectal cancer. These criteria may be used for selection of patients for local excision of down-staged rectal tumors, because patients with p-MR could be easily ruled out.

Citations

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  • The value of multimodality MR in T staging evaluation after neoadjuvant therapy for rectal cancer
    Bin Liu, Chuan Sun, Xinyu Zhao, Lingyu Liu, Shuang Liu, Haichuan Ma
    Technology and Health Care.2024; 32(2): 615.     CrossRef
  • Feasibility of endoscopic techniques in assessing the radicality of chemoradiotherapy in patients with rectal cancer
    A. A. Salimova, M. V. Makarova, M. Yu. Kurdanova, Yu. P. Kuvshinov, I. A. Karasev, T. S. Davydkina
    Surgery and Oncology.2024; 14(2): 48.     CrossRef
  • Clinical predictors of pathological good response in locally advanced rectal cancer
    Kongfeng Shao, Rong Zheng, Anchuan Li, Xiaobo Li, Benhua Xu
    Radiation Oncology.2021;[Epub]     CrossRef
  • A prospective clinical study assessing the presence of exfoliated cancer cells and rectal washout including tumors in patients who receive neoadjuvant chemoradiotherapy for rectal cancer
    Kazutake Okada, Sotaro Sadahiro, Yutaro Kamei, Lin Fung Chan, Takashi Ogimi, Hiroshi Miyakita, Gota Saito, Akira Tanaka, Toshiyuki Suzuki
    Surgery Today.2020; 50(4): 352.     CrossRef
  • Oncologic Risk of Rectal Preservation Against Medical Advice After Chemoradiotherapy for Rectal Cancer: A Multicenter Comparative Cross‐Sectional Study with Rectal Preservation as Supported by Surgeon
    Kwang‐Seop Song, Sung Chan Park, Dae Kyung Sohn, Jae Hwan Oh, Min Jung Kim, Ji Won Park, Seung‐Bum Ryoo, Seung‐Yong Jeong, Kyu Joo Park, Heung‐Kwon Oh, Duck‐Woo Kim, Sung‐Bum Kang
    World Journal of Surgery.2019; 43(12): 3216.     CrossRef
  • Endoscopic assessment of tumor regression after preoperative chemoradiotherapy as a prognostic marker in locally advanced rectal cancer
    Dae Kyung Sohn, Kyung Su Han, Byung Chang Kim, Chang Won Hong, Hee Jin Chang, Ji Yeon Baek, Min Ju Kim, Sung Chan Park, Jae Hwan Oh, Dae Yong Kim
    Surgical Oncology.2017; 26(4): 453.     CrossRef
  • Advances in organ preserving strategies in rectal cancer patients
    Rutger CH. Stijns, Mike-Stephen R. Tromp, Niek Hugen, Johannes HW de Wilt
    European Journal of Surgical Oncology.2017;[Epub]     CrossRef
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Do Biliary Complications after Hypofractionated Radiation Therapy in Hepatocellular Carcinoma Matter?
Jeong Il Yu, Hee Chul Park, Do Hoon Lim, Seung Woon Paik
Cancer Res Treat. 2016;48(2):574-582.   Published online July 17, 2015
DOI: https://doi.org/10.4143/crt.2015.076
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The purpose of this study is to evaluate the efficacy of hypofractionated radiation therapy (RT) in the treatment of unresectable hepatocellular carcinoma (HCC) after failure of transarterial chemoembolization (TACE) or in cases of refractory HCC, and to investigate biliary complications after hypofractionated RT. Materials and Methods We retrospectively enrolled patients with unresectable, TACE-unresponsive, or refractory HCC treated with hypofractionated RT between July 2006 and December 2012. The perihilar region was defined as the 1-cm area surrounding the right, left, and the common hepatic duct, including the gallbladder and the cystic duct. Significant elevation of total bilirubin was defined as an increase of more than 3.0 mg/dL, and more than two times that of the previous level after completion of RT.
Results
Fifty patients received hypofractionated RT and 27 (54%) had a tumor located within the perihilar region. The median follow-up period was 24.7 months (range, 4.3 to 95.5 months). None of the patients developed classic radiation disease symptoms, but four patients (8%) showed significant elevation of total bilirubin within 1 year after RT. During follow-up, 12 patients (24%) developed radiologic biliary abnormalities, but only two patients had toxicities requiring intervention. Estimated local progression-free survival, progression-free survival, and overall survival of the patients at 3-year post-hypofractionated RT were 89.7%, 11.2%, and 57.4%, respectively. Conclusion Biliary complications associated with a higher dose exposure of hypofractionated RT were minimal, even in the perihilar region. Hypofractionated RT provided excellent local control and may be a valuable option for treatment of unresectable cases of TACE-unresponsive or refractory HCC.

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  • Clinical outcomes and safety of external beam radiotherapy with extensive intrahepatic targets for advanced hepatocellular carcinoma: A single institutional clinical experience
    Sunmin Park, Chai Hong Rim, Won Sup Yoon
    Saudi Journal of Gastroenterology.2024; 30(6): 399.     CrossRef
  • Comparative analysis of clinical treatment outcomes: Breath‐hold vs. free‐breathing techniques in liver stereotactic body radiotherapy
    Kosuke Morishima, Hideomi Yamashita, Tomoyuki Noyama, Atsuto Katano
    Journal of Medical Imaging and Radiation Oncology.2024;[Epub]     CrossRef
  • Evidence-based clinical recommendations for hypofractionated radiotherapy: exploring efficacy and safety - Part 4: Liver and locally recurrent rectal cancer
    Hwa Kyung Byun, Gyu Sang Yoo, Soo-Yoon Sung, Jin-Ho Song, Byoung Hyuck Kim, Yoo-Kang Kwak, Yeon Joo Kim, Yeon-Sil Kim, Kyung Su Kim
    Radiation Oncology Journal.2024; 42(4): 247.     CrossRef
  • Pencil Beam Scanning Carbon Ion Radiotherapy for Hepatocellular Carcinoma
    Wenna Zhang, Xin Cai, Jiayao Sun, Weiwei Wang, Jingfang Zhao, Qing Zhang, Guoliang Jiang, Zheng Wang
    Journal of Hepatocellular Carcinoma.2023; Volume 10: 2397.     CrossRef
  • Hypofractionation in Hepatocellular Carcinoma – The Effect of Fractionation Size
    S. Lewis, A. Barry, M.A. Hawkins
    Clinical Oncology.2022; 34(5): e195.     CrossRef
  • Potential of novel colchicine dosage schedule for the palliative treatment of advanced hepatocellular carcinoma
    Zu‐Yau Lin, Ming‐Lun Yeh, Ching‐I Huang, Shinn‐Cherng Chen, Chung‐Feng Huang, Jee‐Fu Huang, Chia‐Yen Dai, Ming‐Lung Yu, Wan‐Long Chuang
    The Kaohsiung Journal of Medical Sciences.2021; 37(7): 616.     CrossRef
  • The feasibility of transcatheter arterial chemoembolization following radiation therapy for hepatocellular carcinoma
    Mostafa Hamada, Eisuke Ueshima, Takeaki Ishihara, Yutaka Koide, Takuya Okada, Hiroki Horinouchi, Jun Ishida, Hiroshi Mayahara, Koji Sasaki, Tomoyuki Gentsu, Keitaro Sofue, Masato Yamaguchi, Ryohei Sasaki, Koji Sugimoto, Takamichi Murakami
    Acta Radiologica Open.2021;[Epub]     CrossRef
  • Stereotactic body radiation therapy vs. radiofrequency ablation in Asian patients with hepatocellular carcinoma
    Nalee Kim, Jason Cheng, Inkyung Jung, Ja Der Liang, Yu Lueng Shih, Wen-Yen Huang, Tomoki Kimura, Victor H.F. Lee, Zhao Chong Zeng, Ren Zhenggan, Chul Seung Kay, Seok Jae Heo, Jong Yoon Won, Jinsil Seong
    Journal of Hepatology.2020; 73(1): 121.     CrossRef
  • Do Biliary Complications after Proton Beam Therapy for Perihilar Hepatocellular Carcinoma Matter?
    Gyu Sang Yoo, Jeong Il Yu, Hee Chul Park, Dongho Hyun, Woo Kyoung Jeong, Ho Yeong Lim, Moon Seok Choi, Sang Yun Ha
    Cancers.2020; 12(9): 2395.     CrossRef
  • Clinical significance of radiotherapy before and/or during nivolumab treatment in hepatocellular carcinoma
    Jeong Il Yu, Su Jin Lee, Jeeyun Lee, Ho Yeong Lim, Seung Woon Paik, Gyu Sang Yoo, Changhoon Choi, Hee Chul Park
    Cancer Medicine.2019; 8(16): 6986.     CrossRef
  • Is higher dose always the right answer in stereotactic body radiation therapy for small hepatocellular carcinoma?
    Kyung Hwa Lee, Jeong Il Yu, Hee Chul Park, Su Yeon Park, Jung Suk Shin, Eun Hyuk Shin, Sungkoo Cho, Sang Hoon Jung, Young Yih Han, Do Hoon Lim
    Radiation Oncology Journal.2018; 36(2): 129.     CrossRef
  • Proton therapy for hepatocellular carcinoma: Current knowledges and future perspectives
    Gyu Sang Yoo, Jeong Il Yu, Hee Chul Park
    World Journal of Gastroenterology.2018; 24(28): 3090.     CrossRef
  • The possibility of radiotherapy as downstaging to living donor liver transplantation for hepatocellular carcinoma with portal vein tumor thrombus
    Jin Y. Choi, Jeong I. Yu, Hee C. Park, C. H. David Kwon, Jong M. Kim, Jae‐Won Joh, Gyu‐Seong Choi, Jae B. Park, Sung J. Kim, Seung H. Lee, Won‐Tae Cho, Kyo W. Lee, Byeong‐Gon Na, Dong Kyu Oh, Nuri Lee, Chan W. Cho, Sanghoon Lee, Suk‐Koo Lee
    Liver Transplantation.2017; 23(4): 545.     CrossRef
  • Prevention and treatment of complications of selective internal radiation therapy: Expert guidance and systematic review
    Bruno Sangro, Diego Martínez‐Urbistondo, Lourens Bester, Jose I. Bilbao, Douglas M. Coldwell, Patrick Flamen, Andrew Kennedy, Jens Ricke, Ricky A. Sharma
    Hepatology.2017; 66(3): 969.     CrossRef
  • 12,220 View
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Surgery Alone Versus Surgery Followed by Chemotherapy and Radiotherapy in Resected Extrahepatic Bile Duct Cancer: Treatment Outcome Analysis of 336 Patients
Jung Ho Im, Jinsil Seong, Ik Jae Lee, Joon Seong Park, Dong Sup Yoon, Kyung Sik Kim, Woo Jung Lee, Kyung Ran Park
Cancer Res Treat. 2016;48(2):583-595.   Published online July 22, 2015
DOI: https://doi.org/10.4143/crt.2015.091
AbstractAbstract PDFPubReaderePub
Purpose
This study analyzed the outcomes of patients with resected extrahepatic bile duct cancer (EHBDC) in order to clarify the role of adjuvant treatments in these patients.
Materials and Methods
A total of 336 patients with EHBDC who underwent curative resection between 2001 and 2010 were analyzed retrospectively. The treatment types were as follows: surgery alone (n=168), surgery with chemotherapy (CTx, n=90), surgery with radiotherapy (RT) alone (n=29), and surgery with chemoradiotherapy (CRT, n=49).
Results
The median follow-up period was 63 months. The 5-year rates of locoregional failure-free survival (LRFFS), distant metastasis-free survival (DMFS), progression-free survival (PFS), and overall survival (OS) for all patients were 56.5%, 59.7%, 36.6%, and 42.0%, respectively. In multivariate analysis, surgery with RT and CRT was a significant prognostic factor for LRFFS, and surgery with CTx was a significant prognostic factor for DMFS, and surgery with CTx, RT, and CRT was a significant prognostic factor for PFS (p < 0.05). Surgery with CTx and CRT showed association with superior OS (p < 0.05), and surgery with RT had marginal significance (p=0.078). In multivariate analysis of the R1 resection patients, surgery with CRT showed significant association with OS (p < 0.05).
Conclusion
Adjuvant RT and CTx may be helpful in improving clinical outcomes of patients with resected EHBDC who have a high risk of disease recurrence, particularly R1 resection patients. Conduct of additional prospective, larger-scale studies will be required in order to confirm the benefit of adjuvant RT and CTx in these patients.

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    ACS Applied Materials & Interfaces.2024; 16(20): 25622.     CrossRef
  • Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with biliary tract cancer
    L.-T. Chen, A. Vogel, C. Hsu, M.-H. Chen, W. Fang, E.A. Pangarsa, A. Sharma, M. Ikeda, J.O. Park, C.K. Tan, E. Regala, D. Tai, S. Tanasanvimon, C. Charoentum, C.E. Chee, A. Lui, J. Sow, D.-Y. Oh, M. Ueno, A. Ramaswamy, W.S. Jeo, J. Zhou, G. Curigliano, T.
    ESMO Open.2024; 9(8): 103647.     CrossRef
  • A Mn-doped calcium phosphate nanoparticle-based multifunctional nanocarrier for targeted drug delivery and cellular MR imaging
    Chaohui Zhou, Shenglei Hou, Chusen Huang, Nengqin Jia
    Journal of Nanoparticle Research.2022;[Epub]     CrossRef
  • Neoadjuvant and Adjuvant Therapy in Intrahepatic Cholangiocarcinoma
    Xing Chen, Jinpeng Du, Jiwei Huang, Yong Zeng, Kefei Yuan
    Journal of Clinical and Translational Hepatology.2022; 10(3): 553.     CrossRef
  • Machine Learning: A New Prospect in Multi-Omics Data Analysis of Cancer
    Babak Arjmand, Shayesteh Kokabi Hamidpour, Akram Tayanloo-Beik, Parisa Goodarzi, Hamid Reza Aghayan, Hossein Adibi, Bagher Larijani
    Frontiers in Genetics.2022;[Epub]     CrossRef
  • Clinical efficacy of adjuvant treatments for patients with resected biliary tract cancer: a systematic review and network meta-analysis
    Ye Chen, Baoxia Zhang, Chang Liu, Ye Cao, Cheng Lyu, Meng Qiu
    BMJ Open.2022; 12(4): e051421.     CrossRef
  • A two-fold interpenetration pillar-layered metal-organic frameworks based on BODIPY for chemo-photodynamic therapy
    Yang Meng, Yingying Du, Yanxin Lin, Yu Su, Ruonan Li, Yaqing Feng, Shuxian Meng
    Dyes and Pigments.2021; 188: 109174.     CrossRef
  • Adjuvant Therapy for Resectable Biliary Tract Cancer: A Bayesian Network Analysis
    Xiuqiong Chen, Fanqiao Meng, Hua Xiong, Yanmei Zou
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles
    Jun-O. Jin, Pallavi Singh Chauhan, Ananta Prasad Arukha, Vishal Chavda, Anuj Dubey, Dhananjay Yadav
    Marine Drugs.2021; 19(5): 265.     CrossRef
  • The Role of Adjuvant Chemoradiotherapy in Nonhilar Extrahepatic Bile Duct Cancer: A Long-Term Single-Institution Analysis
    Won Ick Chang, Byoung Hyuck Kim, Hyun-Cheol Kang, Kyubo Kim, Kyung-Hun Lee, Do-Youn Oh, Hongbeom Kim, Wooil Kwon, Jin-Young Jang, Eui Kyu Chie
    International Journal of Radiation Oncology*Biology*Physics.2021; 111(2): 395.     CrossRef
  • A pH-sensitive drug delivery system based on folic acid-targeted HBP-modified mesoporous silica nanoparticles for cancer therapy
    Yan Li, Shuai Wang, Fang Xiang Song, Li Zhang, Wei Yang, Hong Xia Wang, Qian Lin Chen
    Colloids and Surfaces A: Physicochemical and Engineering Aspects.2020; 590: 124470.     CrossRef
  • A meta-analysis of the efficacy of postoperative adjuvant radiotherapy versus no radiotherapy for extrahepatic cholangiocarcinoma and gallbladder carcinoma
    Bixin Ren, Qi Guo, Yongqiang Yang, Lei Liu, Shaohua Wei, Wei Chen, Ye Tian
    Radiation Oncology.2020;[Epub]     CrossRef
  • Current standards and future perspectives in adjuvant treatment for biliary tract cancers
    Angela Lamarca, Julien Edeline, Mairéad G McNamara, Richard A Hubner, Masato Nagino, John Bridgewater, John Primrose, Juan W Valle
    Cancer Treatment Reviews.2020; 84: 101936.     CrossRef
  • Rectal stenosis due to solitary pelvic recurrence of hilar cholangiocarcinoma
    Ikuma Shioi, Yusuke Yamaoka, Akio Shiomi, Hiroyasu Kagawa, Hitoshi Hino, Shoichi Manabe, Daisuke Aizawa
    JGH Open.2020; 4(5): 1014.     CrossRef
  • Role of adjuvant (chemo)radiotherapy for resected extrahepatic cholangiocarcinoma: a meta-analysis
    Xin-qi Shi, Jing-yu Zhang, Hua Tian, Ling-na Tang, Ai-lin Li
    Journal of Zhejiang University-SCIENCE B.2020; 21(7): 549.     CrossRef
  • Italian Clinical Practice Guidelines on Cholangiocarcinoma – Part II: Treatment
    Domenico Alvaro, Cesare Hassan, Vincenzo Cardinale, Guido Carpino, Luca Fabris, Enrico Gringeri, Vincenza Granata, Massimiliano Mutignani, Helen Morement, Felice Giuliante, Alfredo Guglielmi, Lorenzo Ridola, Giuseppe Tonini, Marco Marzioni, Gianluca Grazi
    Digestive and Liver Disease.2020; 52(12): 1430.     CrossRef
  • The Evolving Role of Radiation Therapy in the Treatment of Biliary Tract Cancer
    Eleni Gkika, Maria A. Hawkins, Anca-Ligia Grosu, Thomas B. Brunner
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Sequentially self-assembled polysaccharide-based nanocomplexes for combined chemotherapy and photodynamic therapy of breast cancer
    Yaping Wang, Ming Yang, Junmin Qian, Weijun Xu, Jinlei Wang, Guanghui Hou, Lijie Ji, Aili Suo
    Carbohydrate Polymers.2019; 203: 203.     CrossRef
  • The effect of adjuvant chemotherapy in resectable cholangiocarcinoma: A meta-analysis and systematic review
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    Journal of Clinical Oncology.2019; 37(12): 1015.     CrossRef
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    Xianxian Yao, Xingxing Niu, Kexin Ma, Ping Huang, Julia Grothe, Stefan Kaskel, Yufang Zhu
    Small.2017;[Epub]     CrossRef
  • Resection margin influences survival after pancreatoduodenectomy for distal cholangiocarcinoma
    Terence C. Chua, Anubhav Mittal, Jenny Arena, Amy Sheen, Anthony J. Gill, Jaswinder S. Samra
    The American Journal of Surgery.2017; 213(6): 1072.     CrossRef
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    Langmuir.2017; 33(2): 591.     CrossRef
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    Yumin Zhang, Fan Huang, Chunhua Ren, Lijun Yang, Jianfeng Liu, Zhen Cheng, Liping Chu, Jinjian Liu
    ACS Applied Materials & Interfaces.2017; 9(15): 13016.     CrossRef
  • Adjuvant concurrent chemoradiotherapy with low-dose daily cisplatin for extrahepatic bile duct cancer
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    Cancer Chemotherapy and Pharmacology.2017; 79(6): 1161.     CrossRef
  • Adjuvant chemotherapy for resected biliary tract cancers: a systematic review and meta-analysis
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    HPB.2017; 19(9): 741.     CrossRef
  • Characterisation of the immune-related transcriptome in resected biliary tract cancers
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    European Journal of Cancer.2017; 86: 158.     CrossRef
  • Over 700 Whipples for Pancreaticobiliary Malignancies: Postoperative Morbidity Is an Additional Negative Prognostic Factor for Distal Bile Duct Cancer
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  • miR-1246 and miR-4644 in salivary exosome as potential biomarkers for pancreatobiliary tract cancer
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    Oncology Reports.2016; 36(4): 2375.     CrossRef
  • Surgical Therapy of Cholangiocarcinoma
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Appendiceal Neuroendocrine, Goblet and Signet-Ring Cell Tumors: A Spectrum of Diseases with Different Patterns of Presentation and Outcome
Walid Shaib, Kavya Krishna, Sungjin Kim, Michael Goodman, Jonathan Rock, Zhengjia Chen, Edith Brutcher, Charles III Staley, Shishir K. Maithel, Samih Abdel-Missih, Bassel F. El-Rayes, Tanios Bekaii-Saab
Cancer Res Treat. 2016;48(2):596-604.   Published online June 5, 2015
DOI: https://doi.org/10.4143/crt.2015.029
AbstractAbstract PDFPubReaderePub
Purpose
Appendiceal tumors are a heterogeneous group of diseases that include typical neuroendocrine tumors (TNET), goblet cell carcinoids (GCC), and atypical GCC. Atypical GCC are classified into signet-ring cell cancers (SRCC) and poorly differentiated appendiceal adenocarcinoids. The prognosis and management of these diseases is unclear because there are no prospective studies. The aim of this study is to assess the characteristics and outcome of appendiceal TNET, GCC, and SRCC patients.
Materials and Methods
Appendiceal TNET, GCC, and SRCC patients diagnosed between 1973 and 2011 were identified in the Surveillance Epidemiology and End Results (SEER) database. Demographics, type of surgery, and clinicopathologic characteristics were collected. Survival functions were estimated by the Kaplan-Meier method, and log-rank test was used to assess the difference in overall survival (OS) among the three histologies.
Results
The SEER database yielded 1,021 TNET patients, 1,582 with GCC, and 534 SRCC patients. TNET presented at a younger age (p < 0.001). Patients with SRCC presented with advanced stage disease (p < 0.001). The median OS (mOS) for GCC and TNET patients was not reached; mOS for SRCC was 24 months. Multivariate analysis stratified for stage revealed significantly longer survival for TNET and GCC than SRCC (p < 0.001).
Conclusion
This is the largest report to date for appendiceal neuroendocrine tumor patients, suggesting a spectrum of diseases with different characteristics and outcomes. In this report, we present a treatment approach for this complex spectrum of disease, based on the experience of Ohio State and Emory Universities investigators.

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  • Postoperative 68Ga‐DOTATATE positron emission tomography has a low yield in incidental appendiceal neuroendocrine tumours
    Emilie Pauvert, George Larcos
    ANZ Journal of Surgery.2024; 94(12): 2185.     CrossRef
  • Appendiceal goblet cell carcinoma has marginal advantages from perioperative chemotherapy: a population-based study with an entropy balancing analysis
    Claudio Ricci, Davide Campana, Carlo Ingaldi, Giuseppe Lamberti, Laura Alberici, Valentina Tateo, Giovanni Castagna, Gianluca Ricco, Fulvio Calderaro, Deborah Malvi, Francesca Rosini, Riccardo Casadei
    Langenbeck's Archives of Surgery.2023;[Epub]     CrossRef
  • Appendixneoplasien
    Safak Gül-Klein, Alexander Arnold, Christian Oberender, Matylda Zofia Kuzinska, Miguel Enrique Alberto Vilchez, Martina T. Mogl, Beate Rau
    coloproctology.2023; 45(2): 139.     CrossRef
  • Collision Tumor of the Appendix
    Álvaro Morillo Cox, Tatiana Fernandez Trokhimtchouk, Luis F Flores, Diego Viteri, Olmedo Mancero, Estefanie S Otanez
    Cureus.2023;[Epub]     CrossRef
  • The Promise of Epigenetics Research in the Treatment of Appendiceal Neoplasms
    Luisa Ladel, Wan Ying Tan, Thanushiya Jeyakanthan, Bethsebie Sailo, Anup Sharma, Nita Ahuja
    Cells.2023; 12(15): 1962.     CrossRef
  • Incidental Detection and Management of a Neuroendocrine Carcinoid Tumor of the Appendix in a Young Male Patient
    Anjani H Turaga
    Cureus.2023;[Epub]     CrossRef
  • An International Registry of Peritoneal Carcinomatosis from Appendiceal Goblet Cell Carcinoma Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
    Frederic Mercier, Guillaume Passot, Pierre‐Emmanuel Bonnot, Peter Cashin, Wim Ceelen, Evelyne Decullier, Laurent Villeneuve, Thomas Walter, Edward A. Levine, Olivier Glehen
    World Journal of Surgery.2022; 46(6): 1336.     CrossRef
  • New insights in diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms
    Feng Yin, Zi-Hao Wu, Jin-Ping Lai
    World Journal of Gastroenterology.2022; 28(17): 1751.     CrossRef
  • Goblet Cell Adenocarcinoma of the Appendix: A Systematic Review and Incidence and Survival of 1,225 Cases From an English Cancer Registry
    Kieran Palmer, Scott Weerasuriya, Kandiah Chandrakumaran, Brian Rous, Benjamin E. White, Sangeeta Paisey, Rajaventhan Srirajaskanthan, John K. Ramage
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Current Management of Appendiceal Neoplasms
    Richard S. Hoehn, Caroline J. Rieser, M. Haroon Choudry, Nelya Melnitchouk, Jaclyn Hechtman, Nathan Bahary
    American Society of Clinical Oncology Educational Book.2021; (41): 118.     CrossRef
  • Appendiceal goblet cell carcinomas have poor survival despite completion surgery
    Edward Alabraba, David Mark Pritchard, Rebecca Griffin, Rafael Diaz-Nieto, Melissa Banks, Daniel James Cuthbertson, Stephen Fenwick
    Endocrine.2021; 73(3): 734.     CrossRef
  • Primary adenocarcinoma of the appendix presenting with fresh bleeding per rectum: A case report
    Baijaeek Sain, Arnab Gupta, Samir Bhattacharya, Radha Raman Mondal, Sudip Haldar, Shravasti Roy
    International Journal of Surgery Case Reports.2021; 86: 106285.     CrossRef
  • Omission of Right Hemicolectomy May be Safe for Some Appendiceal Goblet Cell Adenocarcinomas: A Survival Analysis of the National Cancer Database
    Stacy J. Kowalsky, Ibrahim Nassour, Samer AlMasri, Alessandro Paniccia, Amer H. Zureikat, Haroon A. Choudry, James F. Pingpank
    Annals of Surgical Oncology.2021; 28(13): 8916.     CrossRef
  • Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Versus Surgery Without HIPEC for Goblet-Cell Carcinoids and Mixed Adenoneuroendocrine Carcinomas: Propensity Score–Matched Analysis of Centers in the Netherlands and Belgium
    Nina R. Sluiter, Jarmila D. van der Bilt, Dorothée M.R. Croll, Menno R. Vriens, Ignace H.J.T. de Hingh, Patrick Hemmer, Arend G.J. Aalbers, Andreas J.A. Bremers, Wim Ceelen, Andre D’Hoore, Linda J. Schoonmade, Veerle Coupé, Henk Verheul, Geert Kazemier, J
    Clinical Colorectal Cancer.2020; 19(3): e87.     CrossRef
  • Neuroendocrine tumors of the appendix
    V. S. Trifanov, O. I. Kit, E. N. Kolesnikov, A. V. Snezhko, S. V. Sanamyanz, M. A. Kozhushko, M. Yu. Mesheryakova
    Experimental and Clinical Gastroenterology.2020; 174(5): 82.     CrossRef
  • Survival Profile and Prognostic Factors for Appendiceal Mixed Neuroendocrine Non-neuroendocrine Neoplasms: A SEER Population-Based Study
    Mengzhen Zheng, Tong Li, Yan Li, Tengfei Zhang, Lianfeng Zhang, Wang Ma, Lin Zhou
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Appendiceal neoplasm risk associated with complicated acute appendicitis—a population based study
    Elina Lietzén, Juha M. Grönroos, Jukka-Pekka Mecklin, Ari Leppäniemi, Pia Nordström, Tero Rautio, Tuomo Rantanen, Juhani Sand, Hannu Paajanen, Anne Kaljonen, Paulina Salminen
    International Journal of Colorectal Disease.2019; 34(1): 39.     CrossRef
  • Hypofractionated Stereotactic Radiation Therapy for Metastatic Adenocarcinoma ex Goblet Cell Carcinoid of the Appendix: Case Report and Literature Review
    Joseph W. Clyde, Alan W. Katz
    Case Reports in Oncology.2019; 12(3): 807.     CrossRef
  • Goblet cell carcinoid of the appendix – diagnostic challenges and treatment updates: a case report and review of the literature
    Gregory Gilmore, Kristin Jensen, Shreyas Saligram, Thomas P. Sachdev, Subramanyeswara R. Arekapudi
    Journal of Medical Case Reports.2018;[Epub]     CrossRef
  • Prognostic value of chromogranin A in patients with GET/NEN in the pancreas and the small intestine
    Małgorzata Fuksiewicz, Maria Kowalska, Agnieszka Kolasińska-Ćwikła, Jarosław B Ćwikła, Łukasz Sawicki, Katarzyna Roszkowska-Purska, Joanna Drygiel, Beata Kotowicz
    Endocrine Connections.2018; 7(6): 803.     CrossRef
  • Perforated Goblet Cell Carcinoid Tumors of the Appendix: Navigating the Management Conundrum
    Suman B. Koganti, Brian F. Gilchrist, Tresara C. Bell
    International Surgery.2017; 102(3-4): 131.     CrossRef
  • Appendiceal neuroendocrine neoplasms: diagnosis and management
    Krystallenia I Alexandraki, Gregory A Kaltsas, Simona Grozinsky-Glasberg, Eleftherios Chatzellis, Ashley B Grossman
    Endocrine-Related Cancer.2016; 23(1): R27.     CrossRef
  • Goblet cell carcinoids of the appendix: Tumor biology, mutations and management strategies
    Santosh Shenoy
    World Journal of Gastrointestinal Surgery.2016; 8(10): 660.     CrossRef
  • 14,664 View
  • 171 Download
  • 29 Web of Science
  • 23 Crossref
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Clinicopathological Features and Type of Surgery for Lynch Syndrome: Changes during the Past Two Decades
Il Tae Son, Duck-Woo Kim, Seung-Yong Jeong, Young-Kyoung Shin, Myong Hoon Ihn, Heung-Kwon Oh, Sung-Bum Kang, Kyu Joo Park, Jae Hwan Oh, Ja-Lok Ku, Jae-Gahb Park
Cancer Res Treat. 2016;48(2):605-611.   Published online May 26, 2015
DOI: https://doi.org/10.4143/crt.2015.092
AbstractAbstract PDFPubReaderePub
Purpose
The Korean Hereditary Tumor Registry, the first and one of the largest registries of hereditary tumors in Korea, has registered about 500 families with hereditary cancer syndromes. This study evaluates the temporal changes in clinicopathologic features and surgical patterns of Lynch syndrome (LS) patients.
Materials and Methods
Data on 182 unrelated LS patients were collected retrospectively. The patients were divided into the period 1 group (registered in 1990-2004) and 2 (registered in 2005-2014). The clinical characteristics of the two groups were compared to identify changes over time.
Results
The period 1 group included 76 patients; the period 2 group, 106 patients. The mean ages at diagnosis were 45.1 years (range, 13 to 85 years) for group 1 and 49.7 years (range, 20 to 84 years) for group 2 (p=0.015). The TNM stage at diagnosis did not differ significantly— period 1 group: stage 0-I (n=18, 23.7%), II (n=37, 48.7%), III (n=19, 25.0%), and IV (n=2, 2.6%); period 2 group: stage 0-I (n=30, 28.3%), II (n=35, 33.0%), III (n=37, 34.9%), and IV (n=4, 3.8%). Extended resection was more frequently performed (55/76, 72.4%) in the period 1 group than period 2 (49/106, 46.2%) (p=0.001).
Conclusion
Colorectal cancer in patients with LS registered at the Korean Hereditary Tumor Registry is still diagnosed at an advanced stage, more than two decades after registry’s establishment. Segmental resection was more frequently performed in the past decade. A prompt nationwide effort to raise public awareness of hereditary colorectal cancer and to support hereditary cancer registries is required in Korea.

Citations

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  • Universal Screening for Lynch Syndrome Compared with Pedigree-Based Screening: 10-Year Experience in a Tertiary Hospital
    Min Hyun Kim, Duck-Woo Kim, Hye Seung Lee, Su Kyung Bang, Soo Hyun Seo, Kyung Un Park, Heung-Kwon Oh, Sung-Bum Kang
    Cancer Research and Treatment.2023; 55(1): 179.     CrossRef
  • Deciding the operation type according to mismatch repair status among hereditary nonpolyposis colorectal cancer patients: should a tailored approach be applied, or does one size fit all?
    Chun-Kai Liao, Yueh-Chen Lin, Yu-Jen Hsu, Yih-Jong Chern, Jeng-Fu You, Jy-Ming Chiang
    Hereditary Cancer in Clinical Practice.2021;[Epub]     CrossRef
  • Comparison of oncologic outcomes between patients with Lynch syndrome and sporadic microsatellite instability-high colorectal cancer
    Il Tae Son, Duck-Woo Kim, Min Hyun Kim, Young-Kyoung Shin, Ja-Lok Ku, Heung-Kwon Oh, Sung-Bum Kang, Seung-Yong Jeong, Kyu Joo Park
    Annals of Surgical Treatment and Research.2021; 101(1): 13.     CrossRef
  • Germline Variants in MLH1, MSH2, and MSH6 in Korean Patients with Lynch Syndrome
    Kyoung-Jin Park, Dong Kyung Chang, Hee Cheol Kim, Jong-Won Kim
    Laboratory Medicine Online.2018; 8(4): 156.     CrossRef
  • Efficacy, functional outcome and post‑operative complications of total abdominal colectomy with ileorectal anastomosis vs. segmental colectomy in hereditary non‑polyposis colorectal cancer
    Jie Sun, Mingjie Dong, Xiaoping Xiao
    Experimental and Therapeutic Medicine.2018;[Epub]     CrossRef
  • 12,023 View
  • 106 Download
  • 4 Web of Science
  • 5 Crossref
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Oncologic and Functional Outcomes after Partial Nephrectomy Versus Radical Nephrectomy in T1b Renal Cell Carcinoma: A Multicenter, Matched Case-Control Study in Korean Patients
Hoon Ah Jang, Jin Wook Kim, Seok Soo Byun, Sung Hoo Hong, Young Jun Kim, Young Hyun Park, Kyung Suk Yang, Seok Cho, Jun Cheon, Seok Ho Kang
Cancer Res Treat. 2016;48(2):612-620.   Published online June 5, 2015
DOI: https://doi.org/10.4143/crt.2014.122
AbstractAbstract PDFPubReaderePub
Purpose
The study was to compare the oncologic and functional outcomes of partial nephrectomy (PN) and radical nephrectomy (RN) for pathologically proven T1b renal cell carcinoma using pair-matched groups.
Materials and Methods
We reviewed our prospectively maintained database for RN and PN in T1b renal tumors surgically treated between 1999 and 2011 at five institutions in Korea. Of 611 patients treated with PN or RN for a solitary and NX/N0 M0 renal mass (4-7 cm), 577 (PN, 100; RN, 477) patients with pathologically confirmed pT1b remained for analysis. Study subjects were grouped by PN or RN, then matched by age, sex, comorbidities, body mass index, tumor size and depth, histologic type, and preoperative estimated glomerular filtration rate (eGFR) using propensities score. To evaluate oncologic outcomes, overall survival (OS), cancer- specific survival (CSS), and progression-free survival (PFS) rates were analyzed. The functional outcomes were evaluated by postoperative eGFR.
Results
The median follow-up in the RN group was 48.1 and 42.6 months in the PN group. The estimated 10-year CSS rate (PN 85.7% vs. RN 84.4%, p=0.52) and 5- and estimated 10-year PFS rates (PN: 86.4% and 79.2% vs. RN: 86.0% and 66.1%, p=0.66) did not differ significantly between groups. The estimated 10-year OS rate was significantly higher in the PN group (85.7%) compared to the RN group (73.3%) (p=0.003). PN was less likely to induce new-onset chronic kidney disease (CKD) and end-stage CKD compared with RN.
Conclusion
Our study suggests that patients treated with PN demonstrate a superior OS rate and postoperative renal function with analogous CSS and PFS rates compared with pair-matched patients treated with RN.

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  • Prediction of clinically significant recurrence after partial nephrectomy. Data from the Cancer Registry of Norway with more than five years of follow-up
    Ovidiu S. Barnoiu, Tom B. Johannesen, Lien M. Diep, Eskil S. Pedersen, Karin M. Hjelle, Christian Beisland
    Scandinavian Journal of Urology.2024; 59: 1.     CrossRef
  • Comparison of Oncological and Functional Outcomes of Radical Versus Partial Nephrectomy for cT1b Renal Cell Carcinoma: A Two-Centre, Matched Analysis
    Luna van den Brink, Daniel L. van den Kroonenberg, Niels M. Graafland, Axel Bex, Harrie P. Beerlage, Jeroen R.A. van Moorselaar, Patricia J. Zondervan
    Kidney Cancer.2024; 8(1): 51.     CrossRef
  • Differences in the treatment patterns of small renal masses: A disaggregated analyses by race/ethnicity
    Samuel Carbunaru, Jordan M. Rich, Yassamin Neshatvar, Katie Murray, Madhur Nayan
    Urologic Oncology: Seminars and Original Investigations.2024; 42(12): 453.e1.     CrossRef
  • Three-dimensional visualization techniques improve surgical Decision Making of robotic-assisted partial nephrectomy
    Yuchao Wang, Qiliang Teng, Zhihong Dai, Chunyu Chen, Liren Zhang, Jiaxin Xie, Hao Wang, Zihan Xin, Sishan Chen, Yu Tai, Liang Wang, Bo Fan, Zhiyu Liu
    Heliyon.2024; 10(21): e38806.     CrossRef
  • Renal functional and cardiovascular outcomes of partial nephrectomy versus radical nephrectomy for renal tumors: a systematic review and meta-analysis
    Mario Ochoa-Arvizo, Mariano García-Campa, Karla M. Santos-Santillana, Tobias Klatte, Luis R. García-Chairez, Alejandro D. González-Colmenero, Rigoberto Pallares-Méndez, Daniel E. Cervantes-Miranda, Hiram H. Plata-Huerta, Rene- Rodriguez-Gutierrez, Adrián
    Urologic Oncology: Seminars and Original Investigations.2023; 41(3): 113.     CrossRef
  • Frequency of Benign Lesions in Radiologically Presumed Renal Cell Carcinoma Taking Histopathology as Gold Standard
    Ayesha Khan, Asad Shahzad Hassan, Naseem Akhtar, Rashid Ali, Rehan Mohsin, Altaf Hashmi, Nazish Mughal
    Pakistan Journal of Health Sciences.2023; : 51.     CrossRef
  • Laparoscopic partial versus radical nephrectomy for localized renal cell carcinoma over 4 cm
    Zi-Jun Sun, Feng Liu, Hai-Bin Wei, Da-Hong Zhang
    Journal of Cancer Research and Clinical Oncology.2023; 149(20): 17837.     CrossRef
  • Long-term oncological results of surgical treatment of localized renal tumors
    S. A. Rakul, K. V. Pozdnyakov, R. A. Eloev
    Cancer Urology.2022; 17(4): 27.     CrossRef
  • Near-Infrared Fluorescence Imaging of Renal Cell Carcinoma with ASP5354 in a Mouse Model for Intraoperative Guidance
    Katsunori Teranishi
    International Journal of Molecular Sciences.2022; 23(13): 7228.     CrossRef
  • Comparison of oncologic outcomes between elective partial and radical nephrectomy in patients with renal cell carcinoma in CT1B stadium
    Predrag Maric, Predrag Aleksic, Branko Kosevic, Mirko Jovanovic, Vladimir Bancevic, Dejan Simic, Nemanja Rancic
    Vojnosanitetski pregled.2022; 79(6): 591.     CrossRef
  • Machine learning-based prediction model for late recurrence after surgery in patients with renal cell carcinoma
    Hyung Min Kim, Seok-Soo Byun, Jung Kwon Kim, Chang Wook Jeong, Cheol Kwak, Eu Chang Hwang, Seok Ho Kang, Jinsoo Chung, Yong-June Kim, Yun-Sok Ha, Sung-Hoo Hong
    BMC Medical Informatics and Decision Making.2022;[Epub]     CrossRef
  • Comparison of the oncological, perioperative and functional outcomes of partial nephrectomy versus radical nephrectomy for clinical T1b renal cell carcinoma: A systematic review and meta-analysis of retrospective studies
    Yucong Zhang, Gongwei Long, Haojie Shang, Beichen Ding, Guoliang Sun, Wei Ouyang, Man Liu, Yuan Chen, Heng Li, Hua Xu, Zhangqun Ye
    Asian Journal of Urology.2021; 8(1): 117.     CrossRef
  • Machine Learning Approach to Predict the Probability of Recurrence of Renal Cell Carcinoma After Surgery: Prediction Model Development Study
    HyungMin Kim, Sun Jung Lee, So Jin Park, In Young Choi, Sung-Hoo Hong
    JMIR Medical Informatics.2021; 9(3): e25635.     CrossRef
  • Long-term results of surgical treatment for stage cT1 kidney cancer
    Sergey A. Rakul, Pavel N. Romashchenko, Kirill V. Pozdnyakov, Nikolay A. Maistrenko
    Bulletin of the Russian Military Medical Academy.2021; 23(3): 133.     CrossRef
  • Retroperitoneal laparoscopic partial versus radical nephrectomy for large (≥ 4 cm) and anatomically complex renal tumors: A propensity score matching study
    Wen Deng, Zhengtao Zhou, Jian Zhong, Junhua Li, Xiaoqiang Liu, Luyao Chen, Jingyu Zhu, Bin Fu, Gongxian Wang
    European Journal of Surgical Oncology.2020; 46(7): 1360.     CrossRef
  • Synchronous sporadic bilateral multiple chromophobe renal cell carcinoma accompanied by a clear cell carcinoma and a cyst: A case report
    Fan Yang, Zi-Chen Zhao, A-Jin Hu, Peng-Fei Sun, Bin Zhang, Ming-Chuan Yu, Juan Wang
    World Journal of Clinical Cases.2020; 8(14): 3064.     CrossRef
  • Peri‐operative and local control outcomes of robot‐assisted partial nephrectomy vs percutaneous cryoablation for renal masses: comparison after matching on radiological stage and renal score
    Guillaume Fraisse, Loïc Colleter, Benoit Peyronnet, Zine‐Eddine Khene, Qusay Mandoorah, Yanish Soorojebally, Ali Bourgi, Alexandre De La Taille, Morgan Roupret, Eric De Kerviler, François Desgrandchamps, Karim Bensalah, Alexandra Masson‐Lecomte
    BJU International.2019; 123(4): 632.     CrossRef
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    Raouf Seyam, Mahmoud I. Khalil, Mohamed H. Kamel, Waleed M. Altaweel, Rodney Davis, Nabil K. Bissada
    International Urology and Nephrology.2019; 51(3): 377.     CrossRef
  • Comparison of the long-term follow-up and perioperative outcomes of partial nephrectomy and radical nephrectomy for 4 cm to 7 cm renal cell carcinoma: a systematic review and meta-analysis
    Yu-Li Jiang, Cheng-Xia Peng, Heng-Zi Wang, Lu-Jie Qian
    BMC Urology.2019;[Epub]     CrossRef
  • Partial nephrectomy versus radical nephrectomy for cT2 or greater renal tumors: a systematic review and meta-analysis
    Jingdong Li, Yanping Zhang, Zhihai Teng, Zhenwei Han
    Minerva Urologica e Nefrologica.2019;[Epub]     CrossRef
  • Analysis of survival for patients with chronic kidney disease primarily related to renal cancer surgery
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    BJU International.2018; 121(1): 93.     CrossRef
  • Oncologic Outcomes of Partial Nephrectomy for Stage T3a Renal Cell Cancer
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    Clinical Genitourinary Cancer.2018; 16(3): e613.     CrossRef
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    Miki Haifler, Benjamin T. Ristau, Andrew M. Higgins, Marc C. Smaldone, Alexander Kutikov, Amnon Zisman, Robert G. Uzzo
    Journal of Urology.2018; 199(3): 649.     CrossRef
  • Survival outcomes in patients with large (≥7cm) clear cell renal cell carcinomas treated with nephron-sparing surgery versus radical nephrectomy: Results of a multicenter cohort with long-term follow-up
    M. W. W. Janssen, J. Linxweiler, S. Terwey, S. Rugge, C.-H. Ohlmann, F. Becker, Ch. Thomas, A. Neisius, J. W. Thüroff, S. Siemer, M. Stöckle, F. C. Roos, Christian Schwentner
    PLOS ONE.2018; 13(5): e0196427.     CrossRef
  • Radiofrequency ablation versus cryoablation for T1b renal cell carcinoma: a multi-center study
    Takaaki Hasegawa, Takashi Yamanaka, Hideo Gobara, Masaya Miyazaki, Haruyuki Takaki, Yozo Sato, Yoshitaka Inaba, Koichiro Yamakado
    Japanese Journal of Radiology.2018; 36(9): 551.     CrossRef
  • Néphrectomie partielle pour tumeur de plus de 7 cm : morbidité, résultats oncologiques et fonctionnels (UroCCR-7 study)
    J. Rouffilange, A. Gobet, G. Capon, V. Comat, S. Lagabrielle, A. Guillaume, G. Robert, H. Bensadoun, J.-M. Ferrière, J.-C. Bernhard
    Progrès en Urologie.2018; 28(12): 588.     CrossRef
  • Partial Nephrectomy Versus Radical Nephrectomy for Clinical T1b and T2 Renal Tumors: A Systematic Review and Meta-analysis of Comparative Studies
    Maria Carmen Mir, Ithaar Derweesh, Francesco Porpiglia, Homayoun Zargar, Alexandre Mottrie, Riccardo Autorino
    European Urology.2017; 71(4): 606.     CrossRef
  • Utilization trends and outcomes up to 3 months of open, laparoscopic, and robotic partial nephrectomy
    Jamie S. Pak, Jason J. Lee, Khawaja Bilal, Mark Finkelstein, Michael A. Palese
    Journal of Robotic Surgery.2017; 11(2): 223.     CrossRef
  • Early surgical outcomes and oncological results of robot‐assisted partial nephrectomy: a multicentre study
    Rajan Veeratterapillay, Sanjai K. Addla, Clare Jelley, John Bailie, David Rix, Steve Bromage, Neil Oakley, Robin Weston, Naeem A. Soomro
    BJU International.2017; 120(4): 550.     CrossRef
  • External validation of the Arterial Based Complexity (ABC) scoring system in renal tumors treated by minimally invasive partial nephrectomy
    Liangyou Gu, Xin Ma, Hongzhao Li, Yuanxin Yao, Yongpeng Xie, Luyao Chen, Yu Gao, Xu Zhang
    Journal of Surgical Oncology.2017; 116(4): 507.     CrossRef
  • Partial nephrectomy vs. radical nephrectomy for renal tumors: A meta-analysis of renal function and cardiovascular outcomes
    Zheng Wang, Ganggang Wang, Qinghua Xia, Zhenhua Shang, Xiao Yu, Muwen Wang, Xunbo Jin
    Urologic Oncology: Seminars and Original Investigations.2016; 34(12): 533.e11.     CrossRef
  • Novel Use of Folate-Targeted Intraoperative Fluorescence, OTL38, in Robot-Assisted Laparoscopic Partial Nephrectomy: Report of the First Three Cases
    Cheuk Fan Shum, Clinton D. Bahler, Philip S. Low, Timothy L. Ratliff, Steven V. Kheyfets, Jay P. Natarajan, George E. Sandusky, Chandru P. Sundaram
    Journal of Endourology Case Reports.2016; 2(1): 189.     CrossRef
  • Recommandations en onco-urologie 2016-2018 du CCAFU : Cancer du rein
    K. Bensalah, L. Albiges, J.-C. Bernhard, P. Bigot, T. Bodin, R. Boissier, J.-M. Corréas, P. Gimel, J.-A. Long, F.-X. Nouhaud, I. Ouzaïd, P. Paparel, N. Rioux-Leclercq, A. Méjean
    Progrès en Urologie.2016; 27: S27.     CrossRef
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Conditional Survival and Associated Prognostic Factors in Patients with Upper Tract Urothelial Carcinoma after Radical Nephroureterectomy: A Retrospective Study at a Single Institution
Minyong Kang, Hyung Suk Kim, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku
Cancer Res Treat. 2016;48(2):621-631.   Published online September 9, 2015
DOI: https://doi.org/10.4143/crt.2015.220
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The purpose of this study is to evaluate the changes of conditional survival (CS) probabilities and to identify the prognostic parameters that significantly affect CS over time post-surgery in upper tract urothelial carcinoma (UTUC) patients. Materials and Methods A total of 330 patients were examined in the final analysis. Primary end point was conditional cancer-specific survival (CSS), overall survival (OS), and intravesical recurrence-free survival (IVRFS) after surgery. The Kaplan-Meier method was used for calculation of CS. Cox regression hazard ratio model was used to determine the predictors of CS.
Results
UTUC patients who had already survived 5 years after radical nephroureterectomy had a more favorable CS probability in all given survivorships compared to those with shorter survival times. Patients with unfavorable pathologic features showed a higher increment of 5-year conditional CSS and OS compared to their counterparts. For 5-year conditional CSS, several factors, including high-grade tumor, lymphovascular invasion, and tumor location showed significant association with risk elevation over time. Only age remained as a predictor of 5-year conditional OS with increased risk in all given survivorships. For 5-year IVRFS, no variables remained as significant predictive factors over time after surgery. Conclusion Our study provides valuable information for practical survival estimation and relevant prognostic factors for patients with UTUC after surgery.

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  • Adjuvant Chemotherapy after Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma with Variant Histology: A Systematic Review and Meta-Analysis of Survival Outcomes
    Jinhyung Jeon, Jae Heon Kim, Jee Soo Ha, Won Jae Yang, Kang Su Cho, Do Kyung Kim
    Urologia Internationalis.2024; 108(4): 339.     CrossRef
  • Dynamic estimates of survival in oncocytic cell carcinoma of the thyroid
    Yang Shi, Yuenan Zheng, Hao Zhang, Wenwu Dong, Ping Zhang
    Discover Oncology.2023;[Epub]     CrossRef
  • Factors Predicting Oncological Outcomes of Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma in Taiwan
    I-Hsuan Alan Chen, Chao-Hsiang Chang, Chi-Ping Huang, Wen-Jeng Wu, Ching-Chia Li, Chung-Hsin Chen, Chao-Yuan Huang, Chi-Wen Lo, Chih-Chin Yu, Chung-You Tsai, Wei-Che Wu, Jen-Shu Tseng, Wun-Rong Lin, Yuan-Hong Jiang, Yu-Khun Lee, Yeong-Chin Jou, Ian-Seng C
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • A retrospective multicenter comparison of conditional cancer-specific survival between laparoscopic and open radical nephroureterectomy in locally advanced upper tract urothelial carcinoma
    Sung Han Kim, Mi Kyung Song, Ja Hyeon Ku, Seok Ho Kang, Byong Chang Jeong, Bumsik Hong, Ho Kyung Seo, Isaac Yi Kim
    PLOS ONE.2021; 16(10): e0255965.     CrossRef
  • Contemporary conditional cancer‐specific survival after radical nephroureterectomy in patients with nonmetastatic urothelial carcinoma of upper urinary tract
    Giuseppe Rosiello, Carlotta Palumbo, Sophie Knipper, Angela Pecoraro, Stefano Luzzago, Marina Deuker, Francesco A. Mistretta, Zhe Tian, Nicola Fossati, Andrea Gallina, Francesco Montorsi, Shahrokh F. Shariat, Fred Saad, Alberto Briganti, Pierre I. Karakie
    Journal of Surgical Oncology.2020; 121(7): 1154.     CrossRef
  • Dynamic evaluation of conditional survival in patients with oral squamous cell carcinoma after surgical resection: A large-scale prospective study
    Lingjun Yan, Fa Chen, Lin Chen, Jing Lin, Qing Chen, Xiaodan Bao, Yu Qiu, Lisong Lin, Xiaoyan Zheng, Lizhen Pan, Jing Wang, Zhijian Hu, Fengqiong Liu, Baochang He, Bin Shi
    Oral Oncology.2020; 104: 104639.     CrossRef
  • Gender Is a Significant Prognostic Factor for Upper Tract Urothelial Carcinoma: A Large Hospital-Based Cancer Registry Study in an Endemic Area
    Chun-Chieh Huang, Yu-Li Su, Hao-Lun Luo, Yen-Ta Chen, Terence T. Sio, Hsuan-Chih Hsu, Chia-Hsuan Lai
    Frontiers in Oncology.2019;[Epub]     CrossRef
  • Prognostic Factors of Overall Survival in Upper Urinary Tract Carcinoma: A Systematic Review and Meta-analysis
    Fausto Petrelli, Mohamed Ismail Yasser Hussein, Ivano Vavassori, Sandro Barni
    Urology.2017; 100: 9.     CrossRef
  • The Conditional Survival with Time of Intravesical Recurrence of Upper Tract Urothelial Carcinoma
    Keisuke Shigeta, Eiji Kikuchi, Masayuki Hagiwara, Toshiyuki Ando, Ryuichi Mizuno, Takayuki Abe, Shuji Mikami, Akira Miyajima, Ken Nakagawa, Mototsugu Oya
    Journal of Urology.2017; 198(6): 1278.     CrossRef
  • Conditional survival in patients with gallbladder cancer
    Yi-Jun Kim, Kyubo Kim
    Chinese Journal of Cancer.2017;[Epub]     CrossRef
  • 10,959 View
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Prognostic Value of Log Odds of Positive Lymph Nodes after Radical Surgery Followed by Adjuvant Treatment in High-Risk Cervical Cancer
Jeanny Kwon, Keun-Yong Eom, In Ah Kim, Jae-Sung Kim, Young-Beom Kim, Jae Hong No, Kidong Kim
Cancer Res Treat. 2016;48(2):632-640.   Published online July 14, 2015
DOI: https://doi.org/10.4143/crt.2015.085
AbstractAbstract PDFPubReaderePub
Purpose
The purpose of this study is to compare the prognostic efficacy of the number and location of positive lymph nodes (LN), LN ratio (LNR), and log odds of positive LNs (LODDs) in highrisk cervical cancer treated with radical surgery and adjuvant treatment. Materials and Methods Fifty high-risk patients who underwent radical hysterectomy and pelvic node dissection followed by adjuvant treatment were analyzed retrospectively. The patients had International Federation of Gynecology and Obstetrics (FIGO) stage IA2-IIB. Upper LN is defined as common iliac or higher LN, and LNR is the ratio of positive LNs to harvested LNs. LODDs is log odds between positive LNs and negative LNs. Radiotherapy was delivered to the whole pelvis with median 50.4 Gy/28 Fx± to the para-aortic regions. Platinum-based chemotherapy was used in most patients (93%). The median follow-up duration was 80 months. Results The 5-year disease-free survival (DFS) rate was 76.1%, and the overall survival (OS) rate was 86.4%. Treatment failure occurred in 11 patients, and distant failure (DF) was the dominant pattern (90.9%). In univariate analysis, significantly lower DFSwas observed in patients with perineural invasion, ≥ 2 LN metastases, LNR ≥ 10%, upper LN metastasis, and ≥ –1.05 LODDs. In multivariate analysis, ≥ –1.05 LODDs was the only significant factor for DFS (p=0.011). Of patients with LODDs ≥ –1.05, 40.9% experienced DF. LODDs was the only significant prognostic factor for OS as well (p=0.006). Conclusion LODDs ≥ –1.05 was the only significant prognostic factor for both DFS and OS. In patients with LODDs ≥ –1.05, intensified chemotherapy might be required, considering the high rate of DF.

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  • Perineural invasion in cervical cancer: A multicenter retrospective study
    Xiaolin Chen, Hui Duan, Hongwei Zhao, Fangjie He, Lu Yin, Yueping Liu, Lixia Wang, Chunlin Chen
    European Journal of Surgical Oncology.2024; 50(6): 108313.     CrossRef
  • Recent Advances in Cervical Cancer Management: A Review on Novel Prognostic Factors in Primary and Recurrent Tumors
    Angela Santoro, Frediano Inzani, Giuseppe Angelico, Damiano Arciuolo, Emma Bragantini, Antonio Travaglino, Michele Valente, Nicoletta D’Alessandris, Giulia Scaglione, Stefania Sfregola, Alessia Piermattei, Federica Cianfrini, Paola Roberti, Gian Franco Za
    Cancers.2023; 15(4): 1137.     CrossRef
  • Development and Validation of Novel Nomograms to Predict the Overall Survival and Cancer-Specific Survival of Cervical Cancer Patients With Lymph Node Metastasis
    Jianying Yi, Zhili Liu, Lu Wang, Xingxin Zhang, Lili Pi, Chunlei Zhou, Hong Mu
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Treatment Strategies and Prognostic Factors of 2018 FIGO Stage IIIC Cervical Cancer: A Review
    Fengying Qin, Huiting Pang, Tao Yu, Yahong Luo, Yue Dong
    Technology in Cancer Research & Treatment.2022;[Epub]     CrossRef
  • The Log Odds of Positive Lymph Nodes Predict Survival of Advanced-Stage Endometrial Cancer: A Retrospective Analysis of 3230 Patients in the Surveillance, Epidemiology, and End Results Database
    Christopher G. Smith, Quan Chen, Bin Huang, Rachel W. Miller, Christopher P. DeSimone, Charles S. Dietrich, Frederick R. Ueland, Holly H. Gallion, Edward J. Pavlik, John R. van Nagell, Lauren A. Baldwin Branch
    Journal of Gynecologic Surgery.2022; 38(4): 278.     CrossRef
  • The extent of aortic lymphadenectomy in locally advanced cervical cancer impacts on survival
    Antoni Llueca, Javier Escrig, Antonio Gil-Moreno, Virginia Benito, Alicia Hernández, Berta Díaz-Feijoo
    Journal of Gynecologic Oncology.2021;[Epub]     CrossRef
  • Lymph Node Ratio Is a Strong Prognostic Factor in Patients with Early-Stage Cervical Cancer Undergoing Minimally Invasive Radical Hysterectomy
    Se Ik Kim, Tae Hun Kim, Maria Lee, Hee Seung Kim, Hyun Hoon Chung, Taek Sang Lee, Hye Won Jeon, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song
    Yonsei Medical Journal.2021; 62(3): 231.     CrossRef
  • The role of lymph nodes in cervical cancer: incidence and identification of lymph node metastases—a literature review
    Ester P. Olthof, Maaike A. van der Aa, Judit A. Adam, Lukas J. A. Stalpers, Hans H. B. Wenzel, Jacobus van der Velden, Constantijne H. Mom
    International Journal of Clinical Oncology.2021; 26(9): 1600.     CrossRef
  • Prognostic implications of ENE and LODDS in relation to lymph node-positive colorectal cancer location
    Tengfei Li, Yan Yang, Weidong Wu, Zhongmao Fu, Feichi Cheng, Jiahui Qiu, Qi Li, Kundong Zhang, Zai Luo, Zhengjun Qiu, Chen Huang
    Translational Oncology.2021; 14(11): 101190.     CrossRef
  • The prognostic value of lymph node ratio in stage IIIC cervical cancer patients triaged to primary treatment by radical hysterectomy with systematic pelvic and para-aortic lymphadenectomy
    Koray Aslan, Mehmet Mutlu Meydanli, Murat Oz, Yusuf Aytac Tohma, Ali Haberal, Ali Ayhan
    Journal of Gynecologic Oncology.2020;[Epub]     CrossRef
  • Radiomic signature as a predictive factor for lymph node metastasis in early‐stage cervical cancer
    Yangyang Kan, Di Dong, Yuchen Zhang, Wenyan Jiang, Nannan Zhao, Lu Han, Mengjie Fang, Yali Zang, Chaoen Hu, Jie Tian, Chunming Li, Yahong Luo
    Journal of Magnetic Resonance Imaging.2019; 49(1): 304.     CrossRef
  • The Prognostic Impact of the Number of Metastatic Lymph Nodes and a New Prognostic Scoring System for Recurrence in Early-Stage Cervical Cancer with High Risk Factors: A Multicenter Cohort Study (KROG 15-04)
    Jeanny Kwon, Keun-Young Eom, Young Seok Kim, Won Park, Mison Chun, Jihae Lee, Yong Bae Kim, Won Sup Yoon, Jin Hee Kim, Jin Hwa Choi, Sei Kyung Chang, Bae Kwon Jeong, Seok Ho Lee, Jihye Cha
    Cancer Research and Treatment.2018; 50(3): 964.     CrossRef
  • Log odds of positive lymph nodes may predict survival benefit in patients with node-positive non-small cell lung cancer
    Weiye Deng, Ting Xu, Yifan Wang, Yujin Xu, Pei Yang, Daniel Gomez, Zhongxing Liao
    Lung Cancer.2018; 122: 60.     CrossRef
  • Prognostic significance of lymph node ratio in node-positive cervical cancer patients
    Ji Hyeon Joo, Young Seok Kim, Joo-Hyun Nam
    Medicine.2018; 97(30): e11711.     CrossRef
  • Prognostic Value of Fluorine-18 Fluorodeoxyglucose Uptake of Bone Marrow on Positron Emission Tomography/Computed Tomography for Prediction of Disease Progression in Cervical Cancer
    Jeong Won Lee, Seob Jeon, Seong Taek Mun, Sang Mi Lee
    International Journal of Gynecological Cancer.2017; 27(4): 776.     CrossRef
  • 12,018 View
  • 90 Download
  • 24 Web of Science
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Second Primary Cancer after Diagnosis and Treatment of Cervical Cancer
Myong Cheol Lim, Young-Joo Won, Jiwon Lim, Yeon-Joo Kim, Sang Soo Seo, Sokbom Kang, Eun Sook Lee, Jae Hwan Oh, Joo-Young Kim, Sang-Yoon Park
Cancer Res Treat. 2016;48(2):641-649.   Published online July 17, 2015
DOI: https://doi.org/10.4143/crt.2014.326
AbstractAbstract PDFPubReaderePub
Purpose
This study was conducted to investigate the incidence and survival outcomes of second primary cancers after the diagnosis of cervical cancer.
Materials and Methods
Data from the Korea Central Cancer Registry between 1993 and 2010 were reviewed and analyzed. Standardized incidence ratios (SIRs) of second primary cancers among women with cervical cancer were analyzed. Kaplan-Meier survival curves were constructed for cervical cancer patients with or without a second primary cancer.
Results
Among 72,805 women with cervical cancer, 2,678 (3.68%) developed a second primary cancer within a mean follow-up period of 7.34 years. The overall SIR for a second cancer was 1.08 (95% confidence interval, 1.04 to 1.12). The most frequent sites of second primary cancers were the vagina, bone and joints, vulva, anus, bladder, lung and bronchus, corpus uteri, and esophagus. However, the incidence rates of four second primary cancers (breast, rectum, liver, and brain) were decreased. The 5-year and 10-year overall survival rates were 78.3% and 72.7% in all women with cervical cancer, and for women with a second primary cancer, these rates were 83.2% and 65.5% from the onset of cervical cancer and 54.9% and 46.7% from the onset of the second primary cancer, respectively.
Conclusion
The incidence rates of second primary cancers were increased in women with cervical cancer compared to the general population, with the exception of four decreasing cancers. The 10-year overall survival rates were decreased in cervical cancer patients with a second primary cancer.

Citations

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  • The risk for subsequent primary lung cancer after cervical carcinoma: A quantitative analysis based on 864,627 cases
    Sheng Gong, Gang Li, Dan Li, Yu Liu, Banggui Wu, Yan Wang
    PLOS ONE.2024; 19(6): e0305670.     CrossRef
  • Increased risk of subsequent primary lung cancer among female hormone-related cancer patients: A meta-analysis based on over four million cases
    Yan Wang, Wenpeng Song, Haoyu Wang, Guonian Zhu, Yangqian Li, Zhoufeng Wang, Weimin Li, Guowei Che
    Chinese Medical Journal.2024; 137(15): 1790.     CrossRef
  • Association between radiation therapy for primary endometrial cancer and risk of second primary malignancies: a retrospective cohort study
    Yuebo Wang, Yanan Cai
    Scientific Reports.2024;[Epub]     CrossRef
  • Nomograms constructed for predicting diagnosis and prognosis in cervical cancer patients with second primary malignancies: a SEER database analysis
    Ning Xie, Jie Lin, Linying Liu, Sufang Deng, Haijuan Yu, Yang Sun
    Journal of Cancer Research and Clinical Oncology.2023; 149(14): 13201.     CrossRef
  • Differences of characteristics, influencing factors, and treatment effects on the survival in patients with first and second primary cervical cancer
    Fan Zhang, Ping Yu, Lixia Xu, Xuwei Chen, Junqiang Du
    Preventive Medicine Reports.2023; 36: 102504.     CrossRef
  • Second primary malignancies in cervical cancer and endometrial cancer survivors: a population-based analysis
    Kejie Huang, Lijuan Xu, Mingfang Jia, Wenmin Liu, Shijie Wang, Jianglong Han, Yanbo Li, Qibin Song, Zhenming Fu
    Aging.2022; 14(9): 3836.     CrossRef
  • Second Malignancies Following Primary Cervical Cancer Diagnosis: Analysis of the SEER Database
    Oluwasegun A Akinyemi, Faith O Abodunrin, Tsion F Andine, Kindha Elleissy Nasef, Bolarinwa Akinwumi, Ayobami Oduwole, Christina Lipscombe, Ademola S Ojo, Mary Fakorede
    Cureus.2022;[Epub]     CrossRef
  • Conditional relative survival of cervical cancer: a Korean National Cancer Registry Study
    Dong Wook Shin, Jaeman Bae, Johyun Ha, Kyu-Won Jung
    Journal of Gynecologic Oncology.2021;[Epub]     CrossRef
  • MicroRNAs expression analysis shows key affirmation of Synaptopodin-2 as a novel prognostic and therapeutic biomarker for colorectal and cervical cancers
    Md. Shahadat Hossain, Mahafujul Islam Quadery Tonmoy, Md. Nur Islam, Md. Sajedul Islam, Ibrahim Khalil Afif, Arpita Singha Roy, Atqiya Fariha, Hasan Al Reza, Newaz Mohammed Bahadur, Md. Mizanur Rahaman
    Heliyon.2021; 7(6): e07347.     CrossRef
  • Increased risk of second cancers at sites associated with HPV after a prior HPV-associated malignancy, a systematic review and meta-analysis
    Duncan C. Gilbert, Katie Wakeham, Ruth E. Langley, Claire L. Vale
    British Journal of Cancer.2019; 120(2): 256.     CrossRef
  • Leiomyosarcoma of the Rectum as a Radiation-Induced Second Malignancy after Cervical Cancer Treatment: Case Report with Review of the Literature
    Dmytro E. Makhmudov, Olena O. Kolesnik, Natalia N. Lagoda, Maryna O. Volk
    Case Reports in Oncological Medicine.2019; 2019: 1.     CrossRef
  • Incidences and risk factors of metachronous vulvar, vaginal, and anal cancers after cervical cancer diagnosis
    Koji Matsuo, Erin A. Blake, Hiroko Machida, Rachel S. Mandelbaum, Lynda D. Roman, Jason D. Wright
    Gynecologic Oncology.2018; 150(3): 501.     CrossRef
  • Investigation of tumor-tumor interactions in a double human cervical carcinoma xenograft model in nude mice
    Barbara Mertens, Tatiane Cristina de Araujo Nogueira, Dimitrios Topalis, Ruzena Stranska, Robert Snoeck, Graciela Andrei
    Oncotarget.2018; 9(31): 21978.     CrossRef
  • Elevated risk of human papillomavirus‐related second cancers in survivors of anal canal cancer
    Rebecca A. Nelson, Lily L. Lai
    Cancer.2017; 123(20): 4013.     CrossRef
  • 14,090 View
  • 134 Download
  • 21 Web of Science
  • 14 Crossref
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Radiation-Induced Sarcoma: A 15-Year Experience in a Single Large Tertiary Referral Center
Kyung Su Kim, Ji Hyun Chang, Noorie Choi, Han-Soo Kim, Ilkyu Han, Kyung Chul Moon, Il Han Kim, Hak Jae Kim
Cancer Res Treat. 2016;48(2):650-657.   Published online September 9, 2015
DOI: https://doi.org/10.4143/crt.2015.171
AbstractAbstract PDFPubReaderePub
Purpose
The purpose of this study is to report on the incidence and the experience in management of radiation-induced sarcoma (RIS) at a large single center in Korea for 15 years.
Materials and Methods
We retrospectively reviewed the sarcoma registry of a large institution from January 2000 to April 2014.
Results
Out of the 3,674 patients listed in the registry, 33 patients (0.9%) diagnosed with RIS were identified. The median latency of RIS was 12.1 years. The number of cases of RIS increased from four cases in the years 2000-2003 to 14 cases in the years 2012-2014. The most common histology was osteosarcoma (36.4%). The median follow-up period was 23.1 months, the median overall survival (OS) of all patients was 2.9 years, and their 5-year survival rate was 44.7%. Univariate and multivariate analyses showed association of the age at diagnosis (p=0.01) and the treatment aim (p=0.001) with the OS. The median OS and the 5-year survival rate of patients treated with curative surgery (n=19) were 9.6 years and 65%, respectively, and of the conservatively treated patients, 0.7 years and 0% (n=14). Re-irradiation was delivered to nine patients, and radiation toxicity was observed in five patients.
Conclusion
In this study, RIS accounted for 0.9% of the cases of sarcoma, with increasing incidence. Despite the association of curative resection with increased survival, it could be applied to only 58% of the patients. Considering the limited treatment options for RIS, conduct of a genetic study to identify the underlying mechanism of RIS is needed.

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Citations to this article as recorded by  
  • A bone tumor‐like chest wall mass lesion with pathological rib fractures observed 13 years after lung stereotactic body radiotherapy: A case report
    Masaki Matsuda, Jiro Ichikawa, Takafumi Komiyama, Kojiro Onohara, Masahide Saito, Hikaru Nemoto, Mizuki Kubota, Hiroshi Onishi
    Thoracic Cancer.2024; 15(26): 1912.     CrossRef
  • The role of perioperative treatment in radiation-associated soft tissue sarcomas
    Konrad Zasadziński, Mateusz Jacek Spałek
    Oncologie.2024; 26(6): 1065.     CrossRef
  • Clinical and Pathologic Characterization of 94 Radiation-Associated Sarcomas: Our Institutional Experience
    Erica Y. Kao, Abbye E. McEwen, James K. Aden, Stephanie K. Schaub, Robert W. Ricciotti, Jose G. Mantilla
    International Journal of Surgical Pathology.2023; 31(5): 532.     CrossRef
  • Clinico-demographic characteristics and outcomes of radiation-induced sarcomas (RIS): a CanSaRCC study
    Mauricio Fernando Ribeiro, Hagit Peretz Soroka, Zainab Bhura, Ian Hirsch, Jay Wunder, Peter Ferguson, Kim Tsoi, Savtaj Brar, Rebecca Gladdy, Carol Swallow, Peter Chung, Charles Catton, Philip Wong, Geoffrey Watson, Albiruni Ryan Abdul Razak, Abha A. Gupta
    Therapeutic Advances in Medical Oncology.2023;[Epub]     CrossRef
  • Treatment and Outcomes of Radiation-Induced Soft Tissue Sarcomas of the Extremities and Trunk—A Systematic Review of the Literature
    Maria L. Inchaustegui, Kelly Kon-Liao, Kim Ruiz-Arellanos, George Aquilino E. Silva, Marcos R. Gonzalez, Juan Pretell-Mazzini
    Cancers.2023; 15(23): 5584.     CrossRef
  • Temporary Knockdown of p53 During Focal Limb Irradiation Increases the Development of Sarcomas
    Andrea R. Daniel, Chang Su, Nerissa T. Williams, Zhiguo Li, Jianguo Huang, Omar Lopez, Lixia Luo, Yan Ma, Lorraine da Silva Campos, Sara R. Selitsky, Jennifer L. Modliszewski, Siyao Liu, Rosa Hernansaiz-Ballesteros, Yvonne M. Mowery, Diana M. Cardona, Cha
    Cancer Research Communications.2023; 3(12): 2455.     CrossRef
  • Treatment related factors associated with the risk of breast radio-induced-sarcoma
    Céline Mirjolet, Ibrahima Diallo, Aurélie Bertaut, Cristina Veres, Paul Sargos, Sylvie Helfre, Marie-Pierre Sunyach, Gilles Truc, Cécile Le Pechoux, Amaury Paumier, Anne Ducassou, Maria Jolnerovski, Juliette Thariat, Michel Lapeyre, Abel Cordoba, Marc-And
    Radiotherapy and Oncology.2022; 171: 14.     CrossRef
  • Radiation-induced osteosarcoma in the pubic bone after proton radiotherapy for prostate cancer: a case report
    Hiroatsu Nakashima, Tetsuro Takatsu, Reiko Imai
    Journal of Rural Medicine.2022; 17(2): 94.     CrossRef
  • Premalignant Conditions of Bone
    Michael D. Eckhoff, Matthew E. Wells, Osvaldo Padilla, Elizabeth M. Polfer, Christopher J. Castagno, Ahmed M. Thabet, Shaimaa Elzamly, Harry L. Wilson, Rajiv Rajani
    JAAOS: Global Research and Reviews.2022;[Epub]     CrossRef
  • Histology-Specific Prognostication for Radiation-Associated Soft Tissue Sarcoma
    Edmund K. Bartlett, Avinash Sharma, Kenneth Seier, Cristina R. Antonescu, Narasimhan P. Agaram, Bhumika Jadeja, Evan Rosenbaum, Ping Chi, Murray F. Brennan, Li-Xuan Qin, Kaled M. Alektiar, Samuel Singer
    JCO Precision Oncology.2022;[Epub]     CrossRef
  • Radiation-induced soft tissue sarcoma of the neck after radiation therapy for Hodgkin's lymphoma: a clinical case
    Nikolai A. Ognerubov, Tatiana S. Antipova
    Journal of Modern Oncology.2022; 24(3): 325.     CrossRef
  • Prognostic Score-Based Stratification Analysis Reveals Universal Benefits of Radiotherapy on Lowering the Risk of Ipsilateral Breast Event for Ductal Carcinoma In Situ Patients with Different Risk Levels
    Libo Yang, Dongli Lu, Yutian Lai, Mengjia Shen, Qiuxiao Yu, Ting Lei, Tianjie Pu, Hong Bu
    Annals of Surgical Oncology.2021; 28(2): 975.     CrossRef
  • Radiation-Induced Sarcomas of the Head and Neck: A Systematic Review
    Andrés Coca-Pelaz, Antti A. Mäkitie, Primož Strojan, June Corry, Avraham Eisbruch, Jonathan J. Beitler, Sandra Nuyts, Robert Smee, Johannes A. Langendijk, William M. Mendenhall, Cesare Piazza, Alessandra Rinaldo, Alfio Ferlito
    Advances in Therapy.2021; 38(1): 90.     CrossRef
  • En bloc resection and reconstruction in patients with advanced recurrent nasopharyngeal carcinoma and radiation-induced sarcoma of the head and neck
    W.-l. Chen, Y.-M. Liu, B. Zhou, R. Chen, Z.-y. Lin, Z.-q. Huang, Z-x. Huang
    International Journal of Oral and Maxillofacial Surgery.2021; 50(6): 711.     CrossRef
  • Incidence of radiation induced sarcoma attributable to radiotherapy in adults: A retrospective cohort study in the SEER cancer registries across 17 primary tumor sites
    Anson Snow, Alexander Ring, Lucas Struycken, Wendy Mack, Melissa Koç, Julie E. Lang
    Cancer Epidemiology.2021; 70: 101857.     CrossRef
  • Radiation-Induced Sarcoma: A Retrospective Population-Based Study Over 34 Years in a Single Institution
    L.B. Callesen, A. Safwat, H.K. Rose, F.B. Sørensen, T. Baad-Hansen, N. Aggerholm-Pedersen
    Clinical Oncology.2021; 33(5): e232.     CrossRef
  • Proliferating trichilemmal tumour of the eyelid in a 7-year-old girl
    Avery Bryan, Susan Kurian, Yan Li, Paige Bundrick
    BMJ Case Reports.2021; 14(2): e237476.     CrossRef
  • Treating radiation-induced sarcoma of the head and neck: A case report
    Yuka Takumi, Kazufumi Obata, Atsushi Kondo, Ryo Miyata, Ayaka Sasaki, Kenichi Takano
    Otolaryngology Case Reports.2021; 19: 100283.     CrossRef
  • Pelvic Radiation-Induced Sarcoma With Rhabdomyoblastic Differentiation Following Treatment of Cervical Cancer
    Shahd S Almohsen, Hala Alnuaim, Alaa A Salim, Haitham Arabi
    Cureus.2021;[Epub]     CrossRef
  • MYC expression has limited utility in the distinction of undifferentiated radiation‐associated sarcomas from sporadic sarcomas and sarcomatoid carcinoma
    Jeffrey K Mito, Xiaohua Qian, Vickie Y Jo, Leona A Doyle
    Histopathology.2020; 77(4): 667.     CrossRef
  • Sarcomas óseos secundarios
    J.-C. Mattei, A. Griffin, P. Ferguson, G. Venton, J. Wunder, A. Rochwerger
    EMC - Aparato Locomotor.2020; 53(4): 1.     CrossRef
  • Sarcomes osseux secondaires
    J.-C. Mattei, A. Griffin, P. Ferguson, G. Venton, J. Wunder, A. Rochwerger
    EMC - Appareil locomoteur.2020; 34(3): 1.     CrossRef
  • Radiation-Associated Sarcomas
    Jeffrey K. Mito, Devarati Mitra, Leona A. Doyle
    Surgical Pathology Clinics.2019; 12(1): 139.     CrossRef
  • A Comparison of Outcomes and Prognostic Features for Radiation-Associated Angiosarcoma of the Breast and Other Radiation-Associated Sarcomas
    Jeffrey K. Mito, Devarati Mitra, Constance M. Barysauskas, Adrián Mariño-Enriquez, Elizabeth A. Morgan, Christopher D.M. Fletcher, Chandrajit P. Raut, Elizabeth H. Baldini, Leona A. Doyle
    International Journal of Radiation Oncology*Biology*Physics.2019; 104(2): 425.     CrossRef
  • Osteosarcoma of the jaw – experience at the Medical University Vienna and comparative study with international tumor registries
    Christina Eder-Czembirek, Doris Moser, Simone Holawe, Thomas Brodowicz, Jutta Ries, Irene Sulzbacher, Edgar Selzer
    Clinics.2019; 74: e701.     CrossRef
  • Multifocal superficial rapidly growing postirradiation sarcoma mimicking metastatic carcinoma
    Debasis Gochhait, Priyadarshini Dehuri, Vidhyalakshmi Rangarajan, Neelaiah Siddaraju
    Journal of Mid-life Health.2019; 10(2): 101.     CrossRef
  • Radiation-induced sarcoma in a cat following hypofractionated, palliative intent radiation therapy for large-cell lymphoma
    Matthew R Cook, Michael P Martinez, Joelle M Fenger, Noopur C Desai
    Journal of Feline Medicine and Surgery Open Reports.2019;[Epub]     CrossRef
  • Unique Case Report of a Meningeal Sarcoma Arising during Ongoing Treatment for Progressing Intraparenchymal Glioma
    Richard A. Peterson, Bhavani Kashyap, Pamala A. Pawloski, Anna C. Forsberg, Leah R. Hanson
    Case Reports in Oncological Medicine.2019; 2019: 1.     CrossRef
  • Radiation‐associated sarcoma after breast cancer in a nationwide population: Increasing risk of angiosarcoma
    Samuli H. Salminen, Mika M. Sampo, Tom O. Böhling, Laura Tuomikoski, Maija Tarkkanen, Carl P. Blomqvist
    Cancer Medicine.2018; 7(9): 4825.     CrossRef
  • Radiation-Associated Sarcoma of the Neck: Case Series and Systematic Review
    Lawrence Williams, Lyubov Tmanova, Wojciech K. Mydlarz, Brandi Page, Jeremy D. Richmon, Harry Quon, Nicole C. Schmitt
    Annals of Otology, Rhinology & Laryngology.2018; 127(10): 735.     CrossRef
  • Radiation‐associated neoplasia: clinical, pathological and genomic correlates
    Lynette M Sholl, Justine A Barletta, Jason L Hornick
    Histopathology.2017; 70(1): 70.     CrossRef
  • Magnetic Resonance Imaging of Soft Tissue Masses
    Aaron D. Fain, Francesca D. Beaman
    Seminars in Roentgenology.2017; 52(4): 227.     CrossRef
  • Characteristics of tumors that have developed in mice injected with syngenic irradiated mesenchymal stem cells of bone marrow
    E. Yu. Moskaleva, E. S. Zhorova, Yu. P. Semochkina, A. V. Rodina, O. V. Vysotskaya, A. I. Glukhov, A. A. Chukalova, G. A. Posypanova, V. P. Saprykin
    Cell and Tissue Biology.2017; 11(5): 381.     CrossRef
  • Case Report: Primary De Novo Sarcoma In Transplant Pancreas Allograft
    S. Nagaraju, S.J. Grethlein, S. Vaishnav, A.A. Sharfuddin, J.A. Powelson, J.A. Fridell
    Transplantation Proceedings.2017; 49(10): 2352.     CrossRef
  • Radiation-induced osteosarcoma of the maxilla and mandible after radiotherapy for nasopharyngeal carcinoma
    Lie-Qiang Liao, Hong-Hong Yan, Jun-Hao Mai, Wei-Wei Liu, Hao Li, Zhu-Ming Guo, Zong-Yuan Zeng, Xue-Kui Liu
    Chinese Journal of Cancer.2016;[Epub]     CrossRef
  • 13,940 View
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  • 28 Web of Science
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Dental Anomalies as Late Adverse Effect among Young Children Treated for Cancer
Patrycja Proc, Joanna Szczepańska, Adam Skiba, Małgorzata Zubowska, Wojciech Fendler, Wojciech Młynarski
Cancer Res Treat. 2016;48(2):658-667.   Published online October 14, 2015
DOI: https://doi.org/10.4143/crt.2015.193
AbstractAbstract PDFPubReaderePub
Purpose
The aim of this study was to compare the incidence of dental complications in childhood cancer survivors with that of healthy control subjects, and to determine the possible influence of various factors associated with patient and treatment.
Materials and Methods
Sixty-one panoramic radiographs of the dentition of cancer survivors were compared with 521 radiographs of healthy patients at a similar age, between 5 and 18 years. The mean period from termination of therapy was 4.9 years (58.9±34.3 months), and 51 children (83.60%) were under age 5 when therapy began.
Results
Dental anomalies were found in 38 cancer survivors (62.29%) and 69 control subjects (13.24%) (p < 0.001). Agenesis of teeth was found in 19 cancer patients (31.14%) and in 48 control subjects (9.21%). Microdontic teeth were found in 22 cancer survivors (36.06%) and 15 control subjects (2.87%) (p < 0.001), whereas teeth with short roots were found in seven cancer patients (11.47%) and 15 control subjects (2.87%) (p < 0.01). Dental anomalies in cancer patients were more common in some tooth groups and were not observed in others. The frequency of dental anomalies did not show correlation with age at the beginning or termination or time of therapy.
Conclusion
Children under the age of 5 are in a high risk group for dental complications after anticancer treatment. Rudimentary chemotherapy has a considerable impact on the occurrence of dental anomalies.

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  • A Case of Hypophosphatasia Started Enzyme Replacement Therapy Since Babyhood Stage
    Tatsuya Akitomo, Noriko Niizato, Ami Kaneki, Masashi Ogawa, Taku Nishimura, Mariko Kametani, Momoko Usuda, Yuko Iwamoto, Chieko Mitsuhata, Ryota Nomura
    Children.2025; 12(1): 61.     CrossRef
  • Chemotherapy with Alkylating Agents and Dental Anomalies in Children: A Systematic Review
    Patrizia Gallenzi, Angela Malatesta, Edoardo Staderini, Federica Guglielmi
    Journal of Clinical Medicine.2025; 14(3): 1030.     CrossRef
  • Prevalence of, and risk factors for, dental sequelae in adolescents who underwent cancer therapy during childhood
    Judit Rabassa‐Blanco, Lluís Brunet‐Llobet, Paula Marcote‐Sinclair, Sol Balsells‐Mejía, María Genoveva Correa‐Llano, Jaume Miranda‐Rius
    Oral Diseases.2024; 30(2): 604.     CrossRef
  • Dental Abnormalities in Pediatric Patients Receiving Chemotherapy
    Tatsuya Akitomo, Masashi Ogawa, Ami Kaneki, Taku Nishimura, Momoko Usuda, Mariko Kametani, Satoru Kusaka, Yuria Asao, Yuko Iwamoto, Meiko Tachikake, Chieko Mitsuhata, Ryota Nomura
    Journal of Clinical Medicine.2024; 13(10): 2877.     CrossRef
  • Dental management of long-term childhood cancer survivors: a systematic review
    K. Seremidi, S. Gizani, G. Dahllöf, M. Barr-Agholme, D. Kloukos, G. Tsilingaridis
    European Archives of Paediatric Dentistry.2024; 25(5): 611.     CrossRef
  • A Narrative Review of the Association between Dental Abnormalities and Chemotherapy
    Tatsuya Akitomo, Yasuko Tsuge, Chieko Mitsuhata, Ryota Nomura
    Journal of Clinical Medicine.2024; 13(16): 4942.     CrossRef
  • Evaluation of Permanent Tooth Development in Pediatric Cancer Survivors: A Single Center Experience
    Nurşah Eker, Orkun Dinç, Narmin Asadova, Ali Mentes, Dilek Gül, Beste Atasoy, Alican Sarısaltık, Gülnur Tokuç
    The Journal of Pediatric Research.2024; : 155.     CrossRef
  • Dental dysplasia in childhood cancer survivors: a case series of permanent tooth abnormalities
    Yumi Muraki, Atsushi Shioyasono, Mika Nishii, Daisuke Takeda, Junya Kusumoto, Masaya Akashi
    Oral and Maxillofacial Surgery.2024;[Epub]     CrossRef
  • Oral Manifestations: A Warning-Sign in Children with Hematological Disease Acute Lymphocytic Leukemia
    Sandra Clara Soares, Louis J. D. Roux, Ana Rita Castro, Cristina Cardoso Silva, Rita Rodrigues, Viviana M. P. Macho, Fátima Silva, Céu Costa
    Hematology Reports.2023; 15(3): 491.     CrossRef
  • Long‐term effects of chemotherapy and radiation received during early childhood on the developing dentition of pediatric cancer patients
    Morankar Rahul, Mohammad Atif, Shuvadeep Ganguly, Deepam Pushpam, Nitesh Tewari, Vijay Mathur, Sameer Bakhshi
    Special Care in Dentistry.2023; 43(1): 87.     CrossRef
  • Presentation of a Case of Short Root Anomaly in an 11-Year-Old Child
    Angeliki Sofia Trimeridou, Aristidis Arhakis, Konstantinos Arapostathis, Sivakumar Nuvvula
    Case Reports in Dentistry.2023; 2023: 1.     CrossRef
  • A Systematic Review and Meta-Analysis of the Impact of Cancer and Its Treatment Protocol on the Success of Orthodontic Treatment
    Mohammad Khursheed Alam, Mohammed Awawdeh, Sanjeev B. Khanagar, Wael Aboelmaaty, Huda Abutayyem, Haytham Jamil Alswairki, Ahmed Ali Alfawzan, Mohammad Younis Hajeer
    Cancers.2023; 15(22): 5387.     CrossRef
  • Tooth Abnormalities and Their Age-Dependent Occurrence in Leukemia Survivors
    Anna Jodłowska, Lidia Postek-Stefańska
    Cancers.2023; 15(22): 5420.     CrossRef
  • Assessment of Risk Factors for Dental Developmental Disorders in Pediatric Cancer Survivors
    Jihyun Lee, Hyung-Jun Choi, Jaeho Lee, Je Seon Song, Chung-Min Kang
    THE JOURNAL OF THE KOREAN ACADEMY OF PEDTATRIC DENTISTRY.2023; 50(4): 421.     CrossRef
  • The prevalence of dental developmental anomalies among childhood cancer survivors according to types of anticancer treatment
    Elinor Halperson, Vered Matalon, Gal Goldstein, Shirly Saieg Spilberg, Karin Herzog, Avia Fux-Noy, Aviv Shmueli, Diana Ram, Moti Moskovitz
    Scientific Reports.2022;[Epub]     CrossRef
  • Comparative Study of Malocclusions between Cancer Patients and Healthy Peers
    Patrycja Proc, Joanna Szczepanska, Anna Herud, Malgorzata Zubowska, Wojciech Fendler, Monika Lukomska-Szymanska, Wojciech Mlynarski
    International Journal of Environmental Research and Public Health.2022; 19(7): 4045.     CrossRef
  • Variability of dental abnormalities according to the timing of anticancer therapy: A report of two cases
    Gimin Kim, Jaesik Lee
    Pediatric Dental Journal.2022; 32(2): 110.     CrossRef
  • Systemic Anticancer Therapy Details and Dental Adverse Effects in Children
    Anna Jodłowska, Lidia Postek-Stefańska
    International Journal of Environmental Research and Public Health.2022; 19(11): 6936.     CrossRef
  • Oligomicrodontia in a Pediatric Cancer Survivor after Chemotherapy: A Case Report
    Ana Zulijani, Martina Žigante, Luka Morelato, Berislav Perić, Ana Milardović
    Healthcare.2022; 10(8): 1521.     CrossRef
  • Late dental effects in children submitted to chemotherapy: A case report
    M. Bousserouit, L. Benjelloune, S. Chbicheb
    Annals of Medicine and Surgery.2022; 84: 104845.     CrossRef
  • Dental Caries and Dental Anomalies in Children Undergoing Chemotherapy for Malignant Diseases
    Prasad K Musale, Abhinav Liladhar Talekar, Sneha Sunil Kothare
    International Journal of Clinical Pediatric Dentistry.2022; 15(4): 428.     CrossRef
  • Cancer survivors present significantly lower long-term stability of orthodontic treatment: a prospective case–control study
    Maria Mitus-Kenig, Marcin Derwich, Ewa Czochrowska, Elzbieta Pawlowska
    European Journal of Orthodontics.2021; 43(6): 631.     CrossRef
  • The Broad Variability in Dental Age Observed among Childhood Survivors Is Cancer Specific
    Patrycja Proc, Joanna Szczepańska, Małgorzata Zubowska, Beata Zalewska-Szewczyk, Wojciech Młynarski
    Cancer Research and Treatment.2021; 53(1): 252.     CrossRef
  • Head and neck radiotherapy-induced changes in dentomaxillofacial structures detected on panoramic radiographs: A systematic review
    Luciana Munhoz, Danielle Ayumi Nishimura, Christyan Hiroshi Iida, Plauto Christopher Aranha Watanabe, Emiko Saito Arita
    Imaging Science in Dentistry.2021; 51(3): 223.     CrossRef
  • Late adverse effects of childhood acute lymphoblastic leukemia treatment on developing dentition
    Egle Immonen, Atte Nikkilä, Timo Peltomäki, Liisa Aine, Olli Lohi
    Pediatric Blood & Cancer.2021;[Epub]     CrossRef
  • Evaluation of Changes to the Oral Microbiome Based on 16S rRNA Sequencing among Children Treated for Cancer
    Patrycja Proc, Joanna Szczepańska, Beata Zarzycka, Małgorzata Szybka, Maciej Borowiec, Tomasz Płoszaj, Wojciech Fendler, Jędrzej Chrzanowski, Małgorzata Zubowska, Małgorzata Stolarska, Wojciech Młynarski
    Cancers.2021; 14(1): 7.     CrossRef
  • Dental management of a childhood cancer survivor with malformed primary teeth
    Ryo Kameoka, Tomomi Kawakami, Miho Maeda, Tsukasa Hori, Ayako Yanagisawa, Toshiomi Shirase
    Pediatric Dental Journal.2020; 30(1): 45.     CrossRef
  • Exploring the presence of dental anomalies as a consequence of treatment of malignancy: A case report
    A. Juneja, A. Sultan, S. Iqbal
    Journal of Oral Biology and Craniofacial Research.2020; 10(2): 135.     CrossRef
  • Oral Manifestations and Complications in Childhood Acute Myeloid Leukemia
    Francisco Cammarata-Scalisi, Katia Girardi, Luisa Strocchio, Pietro Merli, Annelyse Garret Bernardin, Angela Galeotti, Fabio Magliarditi, Alessandro Inserra, Michele Callea
    Cancers.2020; 12(6): 1634.     CrossRef
  • Dental and craniofacial alterations in long-term survivors of childhood head and neck rhabdomyosarcoma
    Valkiria D'Aiuto de Mattos, Sima Ferman, Denise Maria Araújo Magalhães, Héliton Spíndola Antunes, Simone Queiroz Chaves Lourenço
    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2019; 127(4): 272.     CrossRef
  • Dental caries among childhood cancer survivors
    Patrycja Proc, Joanna Szczepańska, Anna Herud, Małgorzata Zubowska, Wojciech Fendler, Wojciech Młynarski
    Medicine.2019; 98(6): e14279.     CrossRef
  • A case-control study of dental abnormalities and dental maturity in childhood cancer survivors
    Reyna Aguilar Quispe, Ana Carolina Cunha Rodrigues, Ana Maria Greff Buaes, Ana Lucia Alvares Capelozza, Cássia Maria Fischer Rubira, Paulo Sérgio da Silva Santos
    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2019; 128(5): 498.     CrossRef
  • Oral Complications after Antineoplastic Treatment in Pediatric Patients
    Yongjin Lee, Jaehwan Kim, Namki Choi, Seonmi Kim
    THE JOURNAL OF THE KOREAN ACADEMY OF PEDTATRIC DENTISTRY.2019; 46(3): 239.     CrossRef
  • Long-term Adverse Effects of Acute Myeloid Leukemia Treatment on Odontogenesis in a Child
    Magali Hernandez, Cécile Pochon, Pascal Chastagner, Dominique Droz
    International Journal of Clinical Pediatric Dentistry.2019; 12(3): 243.     CrossRef
  • Clinical Risk Factors Influencing Dental Developmental Disturbances in Childhood Cancer Survivors
    Chung-Min Kang, Seung Min Hahn, Hyo Sun Kim, Chuhl Joo Lyu, Jae-Ho Lee, Jinae Lee, Jung Woo Han
    Cancer Research and Treatment.2018; 50(3): 926.     CrossRef
  • Use of new targeted cancer therapies in children: effects on dental development and risk of jaw osteonecrosis: a review
    Magali Hernandez, Bérengère Phulpin, Ludovic Mansuy, Dominique Droz
    Journal of Oral Pathology & Medicine.2017; 46(5): 321.     CrossRef
  • 11,247 View
  • 194 Download
  • 36 Web of Science
  • 36 Crossref
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Validation of Prediction Models for Mismatch Repair Gene Mutations in Koreans
Soo Young Lee, Duck-Woo Kim, Young-Kyoung Shin, Myong Hoon Ihn, Sung Min Lee, Heung-Kwon Oh, Ja-Lok Ku, Seung-Yong Jeong, Jae Bong Lee, Soyeon Ahn, Sungho Won, Sung-Bum Kang
Cancer Res Treat. 2016;48(2):668-675.   Published online June 5, 2015
DOI: https://doi.org/10.4143/crt.2014.288
AbstractAbstract PDFPubReaderePub
Purpose
Lynch syndrome, the commonest hereditary colorectal cancer syndrome, is caused by germline mutations in mismatch repair (MMR) genes. Three recently developed prediction models for MMR gene mutations based on family history and clinical features (MMRPredict, PREMM1,2,6, and MMRPro) have been validated only in Western countries. In this study, we propose validating these prediction models in the Korean population.
Materials and Methods
We collected MMR gene analysis data from 188 individuals in the Korean Hereditary Tumor Registry. The probability of gene mutation was calculated using three prediction models, and the overall diagnostic value of each model compared using receiver operator characteristic (ROC) curves and area under the ROC curve (AUC). Quantitative test characteristics were calculated at sensitivities of 90%, 95%, and 98%.
Results
Of the individuals analyzed, 101 satisfied Amsterdam criteria II, and 87 were suspected hereditary nonpolyposis colorectal cancer. MMR mutations were identified in 62 of the 188 subjects (33.0%). All three prediction models showed a poor predictive value of AUC (MMRPredict, 0.683; PREMM1,2,6, 0.709; MMRPro, 0.590). Within the range of acceptable sensitivity (> 90%), PREMM1,2,6 demonstrated higher specificity than the other models.
Conclusion
In the Korean population, overall predictive values of the three models (MMRPredict, PREMM1,2,6, MMRPro) for MMR gene mutations are poor, compared with their performance in Western populations. A new prediction model is therefore required for the Korean population to detect MMR mutation carriers, reflecting ethnic differences in genotype-phenotype associations.

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  • Performance evaluation of predictive models for detecting MMR gene mutations associated with Lynch syndrome in cancer patients in a Chinese cohort in Taiwan
    Fei‐Hung Hung, Hung‐Pin Peng, Chen‐Fang Hung, Ling‐Ling Hsieh, An‐Suei Yang, Yong Alison Wang
    International Journal of Cancer.2024; 155(12): 2201.     CrossRef
  • Absence of constitutional MLH1 promoter methylation in Pakistani colorectal cancer patients
    Ayesha Azeem, Humaira Naeemi, Noor Muhammad, Asif Loya, Muhammed Aasim Yusuf, Muhammad Usman Rashid
    Gene Reports.2024; 36: 101995.     CrossRef
  • Prevalence and spectrum of MLH1, MSH2, and MSH6 pathogenic germline variants in Pakistani colorectal cancer patients
    Muhammad Usman Rashid, Humaira Naeemi, Noor Muhammad, Asif Loya, Jan Lubiński, Anna Jakubowska, Muhammed Aasim Yusuf
    Hereditary Cancer in Clinical Practice.2019;[Epub]     CrossRef
  • Evaluation of current prediction models for Lynch syndrome: updating the PREMM5 model to identify PMS2 mutation carriers
    A. Goverde, M. C. W. Spaander, D. Nieboer, A. M. W. van den Ouweland, W. N. M. Dinjens, H. J. Dubbink, C. J. Tops, S. W. ten Broeke, M. J. Bruno, R. M. W. Hofstra, E. W. Steyerberg, A. Wagner
    Familial Cancer.2018; 17(3): 361.     CrossRef
  • Advances in Hereditary Colorectal and Pancreatic Cancers
    Meghan L. Underhill, Katharine A. Germansky, Matthew B. Yurgelun
    Clinical Therapeutics.2016;[Epub]     CrossRef
  • 14,134 View
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Aberrant Epigenetic Modifications of LPHN2 Function as a Potential Cisplatin-Specific Biomarker for Human Gastrointestinal Cancer
Mi-Seong Jeon, Sang-Hyun Song, Jiyeon Yun, Jee-Youn Kang, Hwang-Phill Kim, Sae-Won Han, Tae-You Kim
Cancer Res Treat. 2016;48(2):676-686.   Published online September 22, 2015
DOI: https://doi.org/10.4143/crt.2015.153
AbstractAbstract PDFPubReaderePub
Purpose
Epigenetic alterations of specific genes have recently been identified as diagnostic biomarkers for human cancers. However, there are currently no standardized epigenetic biomarkers for drug sensitivity in human gastrointestinal cancer. Therefore, the aim of this study is to identify a novel epigenetic biomarker in gastrointestinal cancer.
Materials and Methods
Using bisulfite sequencing and pyrosequencing analysis, DNA methylation patterns of gastric, colon primary tissues and their cancer cells were analyzed, and histone modifications were analyzed using chromatin immunoprecipitation assay. In addition, cancer cells were exposed to cisplatin and treated with a DNA methyltransferase inhibitor.
Results
We report that in human gastric and colon cancers, latrophilin 2 (LPHN2) is silenced by epigenetic modifications, including CpG island methylation and aberrant histone modifications. We also confirmed that LPHN2 was silenced by DNA hypermethylation in primary gastric and colon tumor tissues compared to their normal counterparts. Interestingly, we found that cancer cells with methylated LPHN2 showed higher sensitivity to cisplatin. Also, 5-aza- 2′-deoxycytidine combined with cisplatin decreased the cytotoxicity of cisplatin in cancer cells with methylated LPHN2. In addition, LPHN2 knockdown in cancer cells with high LPHN2 expression sensitized these cells to the anti-proliferative effects of cisplatin.
Conclusion
In human gastrointestinal cancer, we found that LPHN2 is regulated by epigenetic modifications, and that cancer cells with lower LPHN2 expression show higher sensitivity to cisplatin. Therefore, the methylation status of LPHN2 is a potential novel epigenetic biomarker for cisplatin treatment in human gastric and colon cancers.

Citations

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  • Latrophilin‐3 as a downstream effector of the androgen receptor induces urothelial tumorigenesis
    Takuro Goto, Masato Yasui, Yuki Teramoto, Yujiro Nagata, Taichi Mizushima, Hiroshi Miyamoto
    Molecular Carcinogenesis.2024; 63(10): 1847.     CrossRef
  • Latrophilins as Downstream Effectors of Androgen Receptors including a Splice Variant, AR-V7, Induce Prostate Cancer Progression
    Yuki Teramoto, Mohammad Amin Elahi Najafi, Takuo Matsukawa, Adhya Sharma, Takuro Goto, Hiroshi Miyamoto
    International Journal of Molecular Sciences.2024; 25(13): 7289.     CrossRef
  • Latrophilin-3 as a downstream effector of the androgen receptor induces bladder cancer progression
    Takuro Goto, Yuki Teramoto, Yujiro Nagata, Hiroshi Miyamoto
    Discover Oncology.2024;[Epub]     CrossRef
  • Histone modification: Biomarkers and potential therapies in colorectal cancer
    Xin An, Xiaohua Lan, Zizhen Feng, Xiaohong Li, Qisheng Su
    Annals of Human Genetics.2023; 87(6): 274.     CrossRef
  • Recent advances of nucleic acid-based cancer biomarkers and biosensors
    Jingkun Zhao, Kai Xia, Peng He, Gang Wei, Xin Zhou, Xiaodong Zhang
    Coordination Chemistry Reviews.2023; 497: 215456.     CrossRef
  • Genetic Analysis Reveals Rare Variants in T-Cell Response Gene MR1 Associated with Poor Overall Survival after Urothelial Cancer Diagnosis
    Lisa Bang, Manu Shivakumar, Tullika Garg, Dokyoon Kim
    Cancers.2021; 13(8): 1864.     CrossRef
  • Chromatin accessibility changes are associated with enhanced growth and liver metastasis capacity of acid-adapted colorectal cancer cells
    Zhi-Hang Zhou, Qing-Liang Wang, Lin-Hong Mao, Xiao-Qin Li, Peng Liu, Jin-Wen Song, Xue Liu, Feng Xu, Jing Lei, Song He
    Cell Cycle.2019; 18(4): 511.     CrossRef
  • Copy Number Variation Pattern for Discriminating MACROD2 States of Colorectal Cancer Subtypes
    ShiQi Zhang, XiaoYong Pan, Tao Zeng, Wei Guo, Zijun Gan, Yu-Hang Zhang, Lei Chen, YunHua Zhang, Tao Huang, Yu-Dong Cai
    Frontiers in Bioengineering and Biotechnology.2019;[Epub]     CrossRef
  • Pharmacoepigenetics and pharmacoepigenomics of gastrointestinal cancers
    Angela Lopomo, Fabio Coppedè
    Expert Review of Gastroenterology & Hepatology.2018; 12(1): 49.     CrossRef
  • Elevation of Peripheral BDNF Promoter Methylation Predicts Conversion from Amnestic Mild Cognitive Impairment to Alzheimer’s Disease: A 5-Year Longitudinal Study
    Bing Xie, Yao Xu, Zanchao Liu, Wenxuan Liu, Lei Jiang, Rui Zhang, Dongsheng Cui, Qingfu Zhang, Shunjiang Xu, Ling-Qiang Zhu
    Journal of Alzheimer’s Disease.2017; 56(1): 391.     CrossRef
  • Identification and evolution of latrophilin receptor gene involved in Tribolium castaneum devolopment and female fecundity
    Shanshan Gao, Xing Liu, Juanjuan Liu, Wenfeng Xiong, Xiaowen Song, Wei Wu, Luting Wei, Bin Li
    genesis.2017;[Epub]     CrossRef
  • Pharmacogenetics of response to neoadjuvant paclitaxel treatment for locally advanced breast cancer
    Andric C. Perez-Ortiz, Israel Ramírez, Juan C. Cruz-López, Cynthia Villarreal-Garza, Alexandra Luna-Angulo, Esmeralda Lira-Romero, Salvador Jiménez-Chaidez, José Díaz-Chávez, Juan A. Matus-Santos, Laura Sánchez-Chapul, Patricia Mendoza-Lorenzo, Francisco
    Oncotarget.2017; 8(63): 106454.     CrossRef
  • CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630
    Yan Zhang, Hao Liu, Wende Li, Jiang Yu, Jin Li, Zhiyong Shen, Gentai Ye, Xiaolong Qi, Guoxin Li
    Aging.2017; 9(6): 1585.     CrossRef
  • 12,918 View
  • 144 Download
  • 17 Web of Science
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The Effect of Chemoradiotherapy with SRC Tyrosine Kinase Inhibitor, PP2 and Temozolomide on Malignant Glioma Cells In Vitro and In Vivo
Keun-Yong Eom, Bong Jun Cho, Eun Jung Choi, Jin-Ho Kim, Eui Kyu Chie, Hong-Gyun Wu, Il Han Kim, Sun Ha Paek, Jae-Sung Kim, In Ah Kim
Cancer Res Treat. 2016;48(2):687-697.   Published online June 4, 2015
DOI: https://doi.org/10.4143/crt.2014.320
AbstractAbstract PDFPubReaderePub
Purpose
We investigated the effect of chemoradiotherapy with PP2 and temozolomide (TMZ) on malignant glioma cells using clonogenic assays and in vivo brain tumor model.
Materials and Methods
The effect of PP2 on radiosensitivity of U251 and T98G cells was investigated using clonogenic assays. The expression of E-cadherin, matrix metalloproteinases 2 (MMP2), Ephrin type-A receptor 2 (EphA2), and vascular endothelial growth factor (VEGF) was measured by Western blotting and an accumulation of γH2AX foci 6 hours after radiotherapy was measured after PP2 treatment. The effect of PP2 on migration, invasion, and vasculogenic mimicry formation (VMF) of U251 cells was evaluated. In an orthotopical brain tumor model with U251 cells, PP2 was injected intraperitoneally with or without oral TMZ before, during and after whole brain radiotherapy. Bioluminescence images were taken to visualize in vivo tumors and immunohistochemical staining of VEGF, CD31, EphA2, and hypoxia-inducible factor 1a was performed.
Results
PP2 increased radiosensitivity of U251 and T98G cells without decreasing survival of normal human astrocytes. Chemoradiotherapy with PP2 and TMZ resulted in increased accumulation of γH2AX foci. PP2 induced overexpression of E-cadherin and suppression of MMP2, VEGF, and EphA2. PP2 also compromised invasion, migration, and VMF of U251 cells. In brain tumors, chemoradiotherapy with PP2 and TMZ decreased tumor volume best, but not statistically significantly compared with chemoradiotherapy with TMZ. The expression of VEGF and CD31 was suppressed in PP2-treated tumors.
Conclusion
PP2 enhances radiosensitivity of malignant glioma cells and suppresses invasion and migration of U251 cells. Chemoradiotherapy with PP2 and TMZ resulted in non-significant tumor volume decrease.

Citations

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  • Dihydroartemisinin inhibits EphA2/PI3K/Akt pathway-mediated malignant behaviors and vasculogenic mimicry in glioma stem cells
    Huangde Fu, Shengtian Wu, Hechun Shen, Kai Luo, Zhongxiang Huang, Nankun Lu, Yaolin Li, Qian Lan, Yishun Xian
    Heliyon.2025; 11(3): e42095.     CrossRef
  • c-Src inhibitor PP2 inhibits head and neck cancer progression through regulation of the epithelial–mesenchymal transition
    SunYoung Lee, Sunjung Park, Jae-Sung Ryu, Jaegu Kang, Ikhee Kim, Sumin Son, Bok-Soon Lee, Chul-Ho Kim, Yeon Soo Kim
    Experimental Biology and Medicine.2023; 248(6): 492.     CrossRef
  • Molecular Targeted Therapies in Glioblastoma Multiforme: A Systematic Overview of Global Trends and Findings
    Emir Begagić, Ragib Pugonja, Hakija Bečulić, Amila Čeliković, Lejla Tandir Lihić, Samra Kadić Vukas, Lejla Čejvan, Rasim Skomorac, Edin Selimović, Belma Jaganjac, Fatima Juković-Bihorac, Aldin Jusić, Mirza Pojskić
    Brain Sciences.2023; 13(11): 1602.     CrossRef
  • Hemorrhage in brain tumor – An unresolved issue
    Robert P. Ostrowski, Zhaohui He, Emanuela B. Pucko, Ewa Matyja
    Brain Hemorrhages.2022; 3(2): 98.     CrossRef
  • The interactions of CAP and LYN with the insulin signaling transducer CBL play an important role in polycystic ovary syndrome
    Haoran Shen, Xiao Xu, Zhongpeng Fu, Chengjie Xu, Yao Wang
    Metabolism.2022; 131: 155164.     CrossRef
  • Identification of four key prognostic genes and three potential drugs in human papillomavirus negative head and neck squamous cell carcinoma
    Guocai Tian, You Fu, Dahe Zhang, Jiang Li, Zhiyuan Zhang, Xi Yang
    Cancer Cell International.2021;[Epub]     CrossRef
  • Intracellular Progesterone Receptor and cSrc Protein Working Together to Regulate the Activity of Proteins Involved in Migration and Invasion of Human Glioblastoma Cells
    Claudia Bello-Alvarez, Aylin Del Moral-Morales, Aliesha González-Arenas, Ignacio Camacho-Arroyo
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Synergistic Tumoricidal Effects of Alpha-Lipoic Acid and Radiotherapy on Human Breast Cancer Cells via HMGB1
    Hoon Sik Choi, Jin Hyun Kim, Si Jung Jang, Jeong Won Yun, Ki Mun Kang, Hojin Jeong, In Bong Ha, Bae Kwon Jeong
    Cancer Research and Treatment.2021; 53(3): 685.     CrossRef
  • Temozolomide: An Updated Overview of Resistance Mechanisms, Nanotechnology Advances and Clinical Applications
    Raúl Ortiz, Gloria Perazzoli, Laura Cabeza, Cristina Jiménez-Luna, Raquel Luque, Jose Prados, Consolación Melguizo
    Current Neuropharmacology.2021; 19(4): 513.     CrossRef
  • SRC Tyrosine Kinase Inhibitor and X-rays Combined Effect on Glioblastoma Cell Lines
    Filippo Torrisi, Luigi Minafra, Francesco P. Cammarata, Gaetano Savoca, Marco Calvaruso, Nunzio Vicario, Laura Maccari, Elodie A. Pérès, Hayriye Özçelik, Myriam Bernaudin, Lorenzo Botta, Giorgio Russo, Rosalba Parenti, Samuel Valable
    International Journal of Molecular Sciences.2020; 21(11): 3917.     CrossRef
  • SRC Kinase in Glioblastoma: News from an Old Acquaintance
    Claudia Cirotti, Claudia Contadini, Daniela Barilà
    Cancers.2020; 12(6): 1558.     CrossRef
  • Development of a patient-derived xenograft model of glioblastoma via intravitreal injection in mice
    Jooyoung Lee, Dong Hyun Jo, Jin Hyoung Kim, Chang Sik Cho, Jiwon Esther Han, Yona Kim, Hyoungwoo Park, Seung Ho Yoo, Young Suk Yu, Hyo Eun Moon, Hye Ran Park, Dong Gyu Kim, Jeong Hun Kim, Sun Ha Paek
    Experimental & Molecular Medicine.2019; 51(4): 1.     CrossRef
  • Antagonism between the RNA-binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma development
    Mitzli X. Velasco, Adam Kosti, Gabriela D.A. Guardia, Marcia C. Santos, Allison Tegge, Mei Qiao, Bruna R.S. Correa, Greco Hernández, Erzsebet Kokovay, Pedro A.F. Galante, Luiz O.F. Penalva
    RNA.2019; 25(7): 768.     CrossRef
  • Suppression of the Smurf1 Expression Inhibits Tumor Progression in Gliomas
    Hao Chang, Jingning Zhang, Zengli Miao, Yasuo Ding, Xing Xu, Xudong Zhao, Peng Xu, Qing Wang, Yuchang Lin
    Cellular and Molecular Neurobiology.2018; 38(2): 421.     CrossRef
  • ZEB1‐mediated vasculogenic mimicry formation associates with epithelial–mesenchymal transition and cancer stem cell phenotypes in prostate cancer
    Hua Wang, Bin Huang, Bai Mou Li, Kai Yuan Cao, Chen Qiang Mo, Shuang Jian Jiang, Jin Cheng Pan, Zong Ren Wang, Huan Yi Lin, Dao Hu Wang, Shao Peng Qiu
    Journal of Cellular and Molecular Medicine.2018; 22(8): 3768.     CrossRef
  • CD59 is a potential biomarker of esophageal squamous cell carcinoma radioresistance by affecting DNA repair
    Yuzhen Zhou, Li Chu, Qi Wang, Weixing Dai, Xiaozhou Zhang, Jianfeng Chen, Ling Li, Peipei Ding, Long Zhang, Hongyu Gu, Luying Li, Xinyue Lv, Wei Zhang, Danlei Zhou, Pingzhao Zhang, Guoxiang Cai, Kuaile Zhao, Weiguo Hu
    Cell Death & Disease.2018;[Epub]     CrossRef
  • KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma
    Michael J. Ciesielski, Yahao Bu, Stephan A. Munich, Paola Teegarden, Michael P. Smolinski, James L. Clements, Johnson Y. N. Lau, David G. Hangauer, Robert A. Fenstermaker
    Journal of Neuro-Oncology.2018; 140(3): 519.     CrossRef
  • The function and mechanism of preactivated thiomers in triggering epithelial tight junctions opening
    Yang Zhang, Shurong Zhou, Feiyang Deng, Xianhui Chen, Xing Wang, Yaoqi Wang, Hua Zhang, Wenbing Dai, Bing He, Qiang Zhang, Xueqing Wang
    European Journal of Pharmaceutics and Biopharmaceutics.2018; 133: 188.     CrossRef
  • The dual PI3K/mTOR inhibitor dactolisib elicits anti-tumor activity in vitro and in vivo
    Fei Shi, Jinying Zhang, Hongyu Liu, Liangliang Wu, Hongyu Jiang, Qiyan Wu, Tianyi Liu, Meiqing Lou, Hao Wu
    Oncotarget.2018; 9(1): 706.     CrossRef
  • Mechanism of the Antitumor and Radiosensitizing Effects of a Manganese Porphyrin, MnHex-2-PyP
    Sung-Won Shin, Changhoon Choi, Ga-Haeng Lee, Arang Son, Su-Hyeon Kim, Hee Chul Park, Ines Batinic-Haberle, Won Park
    Antioxidants & Redox Signaling.2017; 27(14): 1067.     CrossRef
  • Combination of sonodynamic with temozolomide inhibits C6 glioma migration and promotes mitochondrial pathway apoptosis via suppressing NHE-1 expression
    Lei Chen, Damin Cong, Yongzhe Li, Dan Wang, Qingsong Li, Shaoshan Hu
    Ultrasonics Sonochemistry.2017;[Epub]     CrossRef
  • Radiosensitizing effect of lapatinib in human epidermal growth factor receptor 2-positive breast cancer cells
    Tosol Yu, Bong Jun Cho, Eun Jung Choi, Ji Min Park, Dan Hyo Kim, In Ah Kim
    Oncotarget.2016; 7(48): 79089.     CrossRef
  • RND3 promotes Snail 1 protein degradation and inhibits glioblastoma cell migration and invasion
    Baohui Liu, Huimin Dong, Xi Lin, Xiangsheng Yang, Xiaojing Yue, Jian Yang, Yuntao Li, Liquan Wu, Xiaonan Zhu, Shenqi Zhang, Daofeng Tian, Junmin Wang, Qiang Cai, Shanping Mao, Qianxue Chen, Jiang Chang
    Oncotarget.2016; 7(50): 82411.     CrossRef
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