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Volume 47(2); April 2015
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Special Articles
Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2012
Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Chang-Mo Oh, Hyunsoon Cho, Duk Hyoung Lee, Kang Hyun Lee
Cancer Res Treat. 2015;47(2):127-141.   Published online March 3, 2015
DOI: https://doi.org/10.4143/crt.2015.060
AbstractAbstract PDFPubReaderePub
Purpose
The aim of this study was to report nationwide cancer statistics in Korea, including incidence, mortality, survival, and prevalence, and their trends. Materials and Methods Incidence data from 1993 to 2012 were obtained from the Korea National Cancer Incidence Database, and vital status was followed through December 31, 2013. Mortality data from 1983 to 2012 were obtained from Statistics Korea. Crude and age-standardized rates for incidence, mortality, and prevalence, and relative survival were calculated. Results A total of 224,177 cancer cases and 73,759 cancer deaths were reported in 2012, and there were 1,234,879 prevalent cases identified in Korea as of January 1, 2013. Over the past 14 years (1999-2012), overall incidence rates have increased by 3.3% per year. The incidence rates of liver and cervical cancers have decreased, while those of thyroid, breast, prostate, and colorectal cancers have increased. Notably, incidence of thyroid cancer increased by 22.3% per year in both sexes and has been the most common cancer since 2009. The mortality for all cancers combined decreased by 2.7% per year from 2002 to 2012. Five-year relative survival rates of patients diagnosed in the last 5 years (2008-2012) have improved by 26.9% compared with those from 1993 to1995. Conclusion Overall cancer mortality rates have declined since 2002 in Korea, while incidence has increased and survival has improved.

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  • Unusual Horner’s Syndrome in Recurrent Breast Cancer: Evaluation Using 18F-FDG PET/CT
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    Nuclear Medicine and Molecular Imaging.2017; 51(1): 93.     CrossRef
  • MAL and TMEM220 are novel DNA methylation markers in human gastric cancer
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  • Clinical Practice Patterns of Radiotherapy in Patients with Hepatocellular Carcinoma: A Korean Radiation Oncology Group Study (KROG 14-07)
    Hyejung Cha, Hee Chul Park, Jeong Il Yu, Tae Hyun Kim, Taek-Keun Nam, Sang Min Yoon, Won Sup Yoon, Jun Won Kim, Mi Sook Kim, Hong Seok Jang, Youngmin Choi, Jin Hee Kim, Chul Seung Kay, Inkyung Jung, Jinsil Seong
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  • Surgical Strategy and Outcome in Patients Undergoing Pancreaticoduodenectomy After Gastric Resection: A Three‐Center Experience with 39 Patients
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    Applied Nursing Research.2017; 33: 108.     CrossRef
  • Derivation and validation of a risk scoring model to predict advanced colorectal neoplasm in adults of all ages
    Hyo‐Joon Yang, Sungkyoung Choi, Soo‐Kyung Park, Yoon Suk Jung, Kyu Yong Choi, Taesung Park, Ji Yeon Kim, Dong Il Park
    Journal of Gastroenterology and Hepatology.2017; 32(7): 1328.     CrossRef
  • A phase II trial of concurrent chemoradiotherapy with weekly docetaxel plus cisplatin treatment for unresectable locally advanced head and neck cancer
    Ji Yun Lee, Jong-Mu Sun, Dongryul Oh, Sung Hee Lim, Sangah Chi, Se-Hoon Lee, Sin-Ho Jung, Myung-Ju Ahn, Yong Chan Ahn, Keunchil Park
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    Supportive Care in Cancer.2017; 25(3): 915.     CrossRef
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  • Trends and Age-Period-Cohort Effects on the Incidence and Mortality Rate of Cervical Cancer in Korea
    Eun-Kyeong Moon, Chang-Mo Oh, Young-Joo Won, Jong-Keun Lee, Kyu-Won Jung, Hyunsoon Cho, Jae Kwan Jun, Myong Cheol Lim, Moran Ki
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  • The number of cycles of neoadjuvant chemotherapy is associated with prognosis of stage IIIc–IV high-grade serous ovarian cancer
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  • Comparison of long-term survival and immediate postoperative liver function after laparoscopic and open distal gastrectomy for early gastric cancer patients with liver cirrhosis
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  • Clinical outcomes in patients treated with radiotherapy after surgery for cervical cancer
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  • Pellino-1 promotes lung carcinogenesis via the stabilization of Slug and Snail through K63-mediated polyubiquitination
    Yoon Kyung Jeon, Chung Kwon Kim, Kyung Rim Hwang, Hye-Young Park, Jaemoon Koh, Doo Hyun Chung, Chang-Woo Lee, Geun-Hyoung Ha
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  • Risk Factors for Thyroid Cancer: A Hospital-Based Case-Control Study in Korean Adults
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  • Association between Metformin Use and Survival in Nonmetastatic Rectal Cancer Treated with a Curative Resection: A Nationwide Population Study
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  • A randomized, multicenter, phase III study of gemcitabine combined with capecitabine versus gemcitabine alone as first-line chemotherapy for advanced pancreatic cancer in South Korea
    Hee Seung Lee, Moon Jae Chung, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Ho Gak Kim, Myung Hwan Noh, Sang Hyub Lee, Yong-Tae Kim, Hyo Jung Kim, Chang Duck Kim, Dong Ki Lee, Kwang Bum Cho, Chang Min Cho, Jong Ho Moon, Dong Uk Kim, Dae Hwan Kang, Youn
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  • Predicting biochemical recurrence in patients with high-risk prostate cancer using the apparent diffusion coefficient of magnetic resonance imaging
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  • Salvage therapy for acute chemorefractory leukemia by allogeneic stem cell transplantation: the Korean experience
    Shin Hye Yoo, Youngil Koh, Dae-Young Kim, Jung-Hee Lee, Je-Hwan Lee, Kyoo-Hyung Lee, Sung-Soo Yoon, Seonyang Park, Sung-Kyu Park, Dae-Sik Hong, Hyeon Gyu Yi, Chul-Soo Kim, Ji Eun Jang, June-Won Cheong, Joonho Moon, Yoo Hong Min, Sang Kyun Sohn, Inho Kim
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  • Prevalence of and Factors Associated with Sarcopenia in Korean Cancer Survivors: Based on Data Obtained by the Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2011
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  • HER2 Amplification and Cetuximab Efficacy in Patients With Metastatic Colorectal Cancer Harboring Wild-type RAS and BRAF
    Jae Ho Jeong, Jihun Kim, Yong Sang Hong, Dalyong Kim, Jeong Eun Kim, Sun Young Kim, Kyu-pyo Kim, Young-Kwang Yoon, Deokhoon Kim, Sung-Min Chun, Yangsoon Park, Se Jin Jang, Tae Won Kim
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  • Is Male Gender a Prognostic Factor for Papillary Thyroid Microcarcinoma?
    Yi Ho Lee, Yu Mi Lee, Tae Yon Sung, Jong Ho Yoon, Dong Eun Song, Tae Yong Kim, Jung Hwan Baek, Jin Suk Ryu, Ki Wook Chung, Suck Joon Hong
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  • Proportion and clinical features of never-smokers with non-small cell lung cancer
    Jaeyoung Cho, Sun Mi Choi, Jinwoo Lee, Chang-Hoon Lee, Sang-Min Lee, Dong-Wan Kim, Jae-Joon Yim, Young Tae Kim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Young Sik Park
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    Im-Ryung Kim, Soo Hyun Kim, Oh Nam Ok, So Hee Kim, Suyeon Lee, Eunju Choi, Seok Jin Kim, Dok Hyun Yoon, Moon Hee Lee
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  • Preoperative Predictive Factors for Complete Cytoreduction and Survival Outcome in Epithelial Ovarian, Tubal, and Peritoneal Cancer After Neoadjuvant Chemotherapy
    Min-Hyun Baek, Shin-Wha Lee, Jeong-Yeol Park, Chae Chun Rhim, Dae-Yeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
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  • Identification of major dietary patterns in Korean adults and their association with cancer risk in the Cancer Screening Examination Cohort
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  • Clinicopathological analysis and risk factors of advanced colorectal neoplasms incidentally detected by 18F-FDG PET-CT
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    European Journal of Gastroenterology & Hepatology.2017; 29(4): 407.     CrossRef
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  • Computational Modeling of complete HOXB13 protein for predicting the functional effect of SNPs and the associated role in hereditary prostate cancer
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    Myong Cheol Lim, Maria Lee, Seung Hyuk Shim, Eun Ji Nam, Jung Yun Lee, Hyun Jung Kim, Yoo-Young Lee, Kwang Beom Lee, Jeong Yeol Park, Yun Hwan Kim, Kyung Do Ki, Yong Jung Song, Hyun Hoon Chung, Sunghoon Kim, Jeong-won Lee, Jae-Weon Kim, Duk-Soo Bae, Jong-
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  • Identification of large genomic rearrangement of BRCA1/2 in high risk patients in Korea
    Do-Hoon Kim, Hyojin Chae, Irene Jo, Jaeeun Yoo, Hyeyoung Lee, Woori Jang, Joonhong Park, Gun Dong Lee, Dong-Seok Jeon, Keun Ho Lee, Soo Young Hur, Byung Joo Chae, Byung Joo Song, Myungshin Kim, Yonggoo Kim
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    Kyoungjune Pak, Seunghyeon Shin, So Jung Kim, Keunyoung Kim, Bum Soo Kim, Seong Jang Kim, Yun Kyung Jeon, Sang Soo Kim, Bo Hyun Kim, In-Joo Kim
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  • Effectiveness of the Korean National Cancer Screening Program in Reducing Gastric Cancer Mortality
    Jae Kwan Jun, Kui Son Choi, Hoo-Yeon Lee, Mina Suh, Boyoung Park, Seung Hoon Song, Kyu Won Jung, Chan Wha Lee, Il Ju Choi, Eun-Cheol Park, Dukhyoung Lee
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  • Increased breast cancer mortality only in the lower education group: age-period-cohort effect in breast cancer mortality by educational level in South Korea, 1983-2012
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  • Fertility Rates in Young Korean Breast Cancer Patients Treated with Gonadotropin-Releasing Hormone and Chemotherapy
    Isaac Kim, Jai Min Ryu, Hyun-June Paik, Sungmin Park, Soo Youn Bae, Se Kyung Lee, Jonghan Yu, Seok Won Kim, Seok Jin Nam, Jeong Eon Lee
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  • Differences in the survival rates of older patients with colorectal cancers in 2003 and 2009
    Je-Wook Shin, Byung Kwan Park, Min Jung Kim, Bun Kim, Byung Chang Kim, Sung Chan Park, Kyung Su Han, Dae Kyung Sohn, Jae Hwan Oh
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  • Common Causes of Postmenopausal Bleeding in Korean Women: 10-Year Outcomes from a Single Medical Center
    Min Kyoung Kim, Yeon Soo Jung, Seung Joo Chon, Bo Hyon Yun, SiHyun Cho, Young Sik Choi, Byung Seok Lee, Seok Kyo Seo
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  • Depression in breast cancer patients who have undergone mastectomy: A national cohort study
    Min-Su Kim, So Young Kim, Jin-Hwan Kim, Bumjung Park, Hyo Geun Choi, Ali Montazeri
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  • Nationwide Population-Based Incidence and Survival Rates of Malignant Central Nervous System Germ Cell Tumors in Korea, 2005-2012
    Seung Hoon Lee, Kyu-Won Jung, Johyun Ha, Chang-Mo Oh, Hyeseon Kim, Hyeon Jin Park, Heon Yoo, Young-Joo Won
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  • Phase II Study of Irinotecan and Cisplatin Combination Chemotherapy in Metastatic, Unresectable Esophageal Cancer
    Miso Kim, Bhumsuk Keam, Tae-Min Kim, Hoon-Gu Kim, Jin-Soo Kim, Sung Sook Lee, Seong Hoon Shin, Min Kyoung Kim, Keon Uk Park, Dong-Wan Kim, Hwan Jung Yun, Jong Seok Lee, Dae Seog Heo
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  • Current Trends of Lung Cancer Surgery and Demographic and Social Factors Related to Changes in the Trends of Lung Cancer Surgery: An Analysis of the National Database from 2010 to 2014
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  • Establishment and characterization of 6 novel patient-derived primary pancreatic ductal adenocarcinoma cell lines from Korean pancreatic cancer patients
    Mi-Ju Kim, Min-Sun Kim, Sung Joo Kim, Soyeon An, Jin Park, Hosub Park, Jae Hoon Lee, Ki-Byung Song, Dae Wook Hwang, Suhwan Chang, Kyu-pyo Kim, Seong-Yun Jeong, Song Cheol Kim, Seung-Mo Hong
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  • Comprehensive Evaluation of the Anti-Helicobacter pylori Activity of Scutellariae Radix
    Ba Wool Lee, Il-Ho Park, Dongsool Yim, Sung Sook Choi
    Natural Product Sciences.2017; 23(1): 46.     CrossRef
  • Inhibitory Effect of D-chiro-inositol on Both Growth and Recurrence of Breast Tumor from MDA-MB-231 Cancer Cells
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  • Cancer mortality-to-incidence ratio as an indicator of cancer management outcomes in Organization for Economic Cooperation and Development countries
    Eunji Choi, Sangeun Lee, Bui Cam Nhung, Mina Suh, Boyoung Park, Jae Kwan Jun, Kui Son Choi
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  • Plasma expression of the intestinal metaplasia markers CDH17 and TFF3 in patients with gastric cancer
    Boram Choi, Hyuk-Joon Lee, Jimin Min, Hwi-Nyeong Choe, Yun-Suk Choi, Young-Gil Son, Hye-Seong Ahn, Yun-Suhk Suh, James R. Goldenring, Han-Kwang Yang
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  • Assessing perceived benefits/barriers and self-efficacy for cervical cancer screening among Korean American women
    Wei-Chen Tung, Minggen Lu, Michelle Granner, Jeeyun Sohn
    Health Care for Women International.2017; 38(9): 945.     CrossRef
  • Reactive oxygen species modulator-1 (Romo1) predicts unfavorable prognosis in colorectal cancer patients
    Hong Jun Kim, Min Jee Jo, Bo Ram Kim, Jung Lim Kim, Yoon A. Jeong, Yoo Jin Na, Seong Hye Park, Suk-young Lee, Dae-Hee Lee, Hye Seung Lee, Baek-hui Kim, Sun Il Lee, Byung Wook Min, Young Do Yoo, Sang Cheul Oh, Hiromu Suzuki
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  • Polyp missing rate and its associated risk factors of referring hospitals for endoscopic resection of advanced colorectal neoplasia
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  • Mammea longifolia Planch. and Triana Fruit Extract Induces Cell Death in the Human Colon Cancer Cell Line, SW480, via Mitochondria-Related Apoptosis and Activation of p53
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  • Liquiritin (LT) exhibits suppressive effects against the growth of human cervical cancer cells through activating Caspase-3 in vitro and xenograft mice in vivo
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  • Fecal Occult Blood Test Results of the National Colorectal Cancer Screening Program in South Korea (2006–2013)
    John Hoon Rim, Taemi Youk, Jung Gu Kang, Byung Kyu Park, Heon Yung Gee, Jeong-Ho Kim, Jongha Yoo
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  • Breast and Cervical Cancer Screening Behavior in Female Cancer Survivors: The Korea National Health and Nutrition Examination Survey, 2007–2012
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  • Measurement of Radon Concentration in Selected Houses in Ibadan, Nigeria
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  • Incidence and mortality of pancreatic cancer on a rapid rise in Taiwan, 1999–2012
    Chao-Ming Tseng, Shih-Pei Huang, Wei-Chih Liao, Chun-Ju Chiang, Ya-Wen Yang, Chi-Yang Chang, Yao-Chun Hsu, Hui-Chi Chen, Han-Sun Chiang, Jaw-Town Lin
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  • Risk factors associated with treatment refusal in lung cancer
    Won Na Suh, Kyoung Ae Kong, Yeji Han, Soo Jung Kim, Su Hwan Lee, Yon Ju Ryu, Jin Hwa Lee, Sung Shine Shim, Yookyung Kim, Jung Hyun Chang
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  • Barriers to Cervical Cancer Screening and Prevention in Young Korean Immigrant Women: Implications for Intervention Development
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  • Epigenetic suppression of the anti-aging geneKLOTHOin human prostate cancer cell lines
    Minkyu Seo, Min Su Kim, Ara Jang, Hyun Joo Chung, Yoohun Noh, Do-Hee Kim, Jaehyouk Lee, Kisung Ko, Soon Chul Myung
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  • The association between physical activity and health-related quality of life among breast cancer survivors
    Woo-kyoung Shin, Sihan Song, So-Youn Jung, Eunsook Lee, Zisun Kim, Hyeong-Gon Moon, Dong-Young Noh, Jung Eun Lee
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  • Induction Chemotherapy with Gemcitabine and Cisplatin Followed by Simultaneous Integrated Boost–Intensity Modulated Radiotherapy with Concurrent Gemcitabine for Locally Advanced Unresectable Pancreatic Cancer: Results from a Feasibility Study
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  • Prognostic value of putative cancer stem cell markers (CD24, CD44, CD133, and ALDH1) in human papillary thyroid carcinoma
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  • Post hoc analyses of East Asian patients from the randomized placebo-controlled PREVAIL trial of enzalutamide in patients with chemotherapy-naïve, metastatic castration-resistant prostate cancer
    Choung Soo Kim, Young Deuk Choi, Sang Eun Lee, Hyun Moo Lee, Takeshi Ueda, Junji Yonese, Takashi Fukagai, Edmund Chiong, Weber Lau, Sarang Abhyankar, Ad Theeuwes, Bertrand Tombal, Tomasz M. Beer, Go Kimura
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  • Will a Fibrin Sealant be Effective as a Seroma Reductant and a Hemostatic Agent in Breast Reconstruction Using a Latissimus Dorsi Flap?
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  • A Multicenter Randomized Phase II Study of Docetaxel vs. Docetaxel Plus Cisplatin vs. Docetaxel Plus S-1 as Second-Line Chemotherapy in Metastatic Gastric Cancer Patients Who Had Progressed after Cisplatin Plus Either S-1 or Capecitabine
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  • Real-World Treatment Patterns among Patients with Advanced Gastric Cancer in South Korea
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  • Development of a Community-Based Palliative Care Model for Advance Cancer Patients in Public Health Centers in Busan, Korea
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  • Estimating utility weights and quality-adjusted life year loss for colorectal cancer-related health states in Korea
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  • Mortality differences by surgical volume among patients with stomach cancer: a threshold for a favorable volume-outcome relationship
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    Ji Young Chang, Ki-Nam Shim, Chung Hyun Tae, Ko Eun Lee, Jihyun Lee, Kang Hoon Lee, Chang Mo Moon, Seong-Eun Kim, Hye-Kyung Jung, Sung-Ae Jung, Joo-Ho Lee, Min-Sun Cho
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  • Metastatic Squamous Cell Carcinoma from Lung Adenocarcinoma after Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy
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    Murat Gultekin, Selin Dundar, Irem Kucukyildiz, Mujdegul Zayifoglu Karaca, Guledal Boztas, Semra Hatice Turan, Ezgi Hacikamiloglu, Bekir Keskinkilic
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  • Anti-neoplastic and Anti-inflammatory Effects of Single and Mixed Extracts of Ulmus Davidiana and Oldenlandia Diffusa on Azoxymethane/dextran Sodium Sulfate-induced Colonic Neoplasms
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  • End-of-life care decisions using a Korean advance directive among cancer patient–caregiver dyads
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  • Zerumbone Suppresses Osteopontin-Induced Cell Invasion Through Inhibiting the FAK/AKT/ROCK Pathway in Human Non-Small Cell Lung Cancer A549 Cells
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    Seok-Soo Byun, Sung Kyu Hong, Sangchul Lee, Ha Rim Kook, Eunsik Lee, Hyeon Hoe Kim, Cheol Kwak, Ja Hyeon Ku, Chang Wook Jeong, Ji Youl Lee, Sung Hoo Hong, Yong-June Kim, Eu Chang Hwang, Tae Gyun Kwon, Tae-Hwan Kim, Seok Ho Kang, Sung Han Kim, Jinsoo Chung
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    E.S. Lee, S.Y. Jung, J.Y. Kim, J.J. Kim, T.K. Yoo, Y.G. Kim, K.S. Lee, E.S. Lee, E.K. Kim, J.W. Min, W. Han, D.Y. Noh, H.G. Moon
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    Hideyuki Akaza, Jae Kyung Roh, Xishan Hao, Suwit Wibulpolprasert, Shinjiro Nozaki, Eun‐Cheol Park, Takashi Fukuda, Shigeto Sonoda, Norie Kawahara
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    Health Policy.2016; 120(6): 580.     CrossRef
  • Changes in the types of liver diseases requiring hepatic resection: a single-institution experience of 9016 cases over a 10-year period
    Hwui-Dong Cho, Shin Hwang, Young-Joo Lee, Kwang-Min Park, Ki-Hun Kim, Jin Cheon Kim, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Sung-Gyu Lee
    Korean Journal of Hepato-Biliary-Pancreatic Surgery.2016; 20(2): 49.     CrossRef
  • The effects of the standardized extracts of Ginkgo biloba on steroidogenesis pathways and aromatase activity in H295R human adrenocortical carcinoma cells
    Mijie Kim, Yong Joo Park, Huiyeon Ahn, Byeonghak Moon, Kyu Hyuck Chung, Seung Min Oh
    Environmental Health and Toxicology.2016; 31: e2016010.     CrossRef
  • Is a Price Increase Policy Enough for Adolescent Smokers?: Factors Affecting the Effectiveness of Increasing Cigarette Prices Among Korean Adolescent Smokers
    Yong Suk Lee, Hong-Suk Kim, Hyung-Do Kim, Ki-Bong Yoo, Sung-In Jang, Eun-Cheol Park
    Nicotine & Tobacco Research.2016; 18(10): 2013.     CrossRef
  • Psychological Status and Associated Factors among Korean Cancer Survivors: a Cross-Sectional Analysis of the Fourth & Fifth Korea National Health and Nutrition Examination Surveys
    Kyung-Hyun Choi, Sang Min Park
    Journal of Korean Medical Science.2016; 31(7): 1105.     CrossRef
  • Genetic Variation in the TAS2R38 Bitter Taste Receptor and Gastric Cancer Risk in Koreans
    Jeong-Hwa Choi, Jeonghee Lee, Il Ju Choi, Young-Woo Kim, Keun Won Ryu, Jeongseon Kim
    Scientific Reports.2016;[Epub]     CrossRef
  • Metabolic Risk Profile and Cancer in Korean Men and Women
    Seulki Ko, Seok-Jun Yoon, Dongwoo Kim, A-Rim Kim, Eun-Jung Kim, Hye-Young Seo
    Journal of Preventive Medicine and Public Health.2016; 49(3): 143.     CrossRef
  • The Lived Experience of Suffering of Family with Cancer Patients: Parse’s Human Becoming Research Method
    Ye-Sook Choi
    The Korean Journal of Hospice and Palliative Care.2016; 19(2): 127.     CrossRef
  • Develop 3D Prostate Cancer Visualization Tool in Smart Care System
    Byung Uk Ahn, Seung Won Shin, Moon Hyung Choi, Seung Eun Jung, Kwang Gi Kim
    Journal of Korea Multimedia Society.2016; 19(2): 163.     CrossRef
  • Estimation of Recurrence Risk After Normal 18F-FDG PET/CT in Nonsmall-Cell Lung Cancer
    Kyoungjune Pak, Seong-Jang Kim, Phillip J. Koo, Samuel Chang
    Cancer Biotherapy and Radiopharmaceuticals.2016; 31(5): 174.     CrossRef
  • Hypofractionated stereotactic body radiotherapy in low- and intermediate-risk prostate carcinoma
    Hun Jung Kim, Jeong Hoon Phak, Woo Chul Kim
    Radiation Oncology Journal.2016; 34(4): 260.     CrossRef
  • Dietary patterns and colorectal cancer risk in a Korean population
    Yoon Park, Jeonghee Lee, Jae Hwan Oh, Aesun Shin, Jeongseon Kim
    Medicine.2016; 95(25): e3759.     CrossRef
  • Snake Venom synergized Cytotoxic Effect of Natural Killer Cells on NCI H358 Human Lung Cancer Cell Growth through Induction of Apoptosis
    Jae Woo Oh, Ho Sueb Song
    The Acupuncture.2016; 33(2): 1.     CrossRef
  • News Portrayal of Cancer: Content Analysis of Threat and Efficacy by Cancer Type and Comparison with Incidence and Mortality in Korea
    Minsun Shim, Yong-Chan Kim, Su Yeon Kye, Keeho Park
    Journal of Korean Medical Science.2016; 31(8): 1231.     CrossRef
  • Performance of Screening Mammography: A Report of the Alliance for Breast Cancer Screening in Korea
    Eun Hye Lee, Keum Won Kim, Young Joong Kim, Dong-Rock Shin, Young Mi Park, Hyo Soon Lim, Jeong Seon Park, Hye-Won Kim, You Me Kim, Hye Jung Kim, Jae Kwan Jun
    Korean Journal of Radiology.2016; 17(4): 489.     CrossRef
  • Identification of an N staging system that predicts oncologic outcome in resected left-sided pancreatic cancer
    Sung Hyun Kim, Ho Kyoung Hwang, Woo Jung Lee, Chang Moo Kang
    Medicine.2016; 95(26): e4035.     CrossRef
  • Association between obesity and local control of advanced rectal cancer after combined surgery and radiotherapy
    Yunseon Choi, Yun-Han Lee, Sung Kwang Park, Heunglae Cho, Ki Jung Ahn
    Radiation Oncology Journal.2016; 34(2): 113.     CrossRef
  • The clinical utilization of radiation therapy in Korea between 2009 and 2013
    Jin-Kyu Kang, Mi-Sook Kim, Won-Il Jang, Young Seok Seo, Hee Jin Kim, Chul Koo Cho, Hyung Jun Yoo, Eun Kyung Paik, Yu Jin Cha, Hyun Jin Song
    Radiation Oncology Journal.2016; 34(2): 88.     CrossRef
  • Relationship between Salt Preference and Gastric Cancer Screening: An Analysis of a Nationwide Survey in Korea
    Ji-Yeon Shin, Jeongseon Kim, Kui Son Choi, Mina Suh, Boyoung Park, Jae Kwan Jun
    Cancer Research and Treatment.2016; 48(3): 1037.     CrossRef
  • Changing Patterns of Primary Treatment in Korean Men with Prostate Cancer Over 10 Years: A Nationwide Population Based Study
    Jinsung Park, Beomseok Suh, Dong Wook Shin, Jun Hyuk Hong, Hanjong Ahn
    Cancer Research and Treatment.2016; 48(3): 899.     CrossRef
  • Effects of hand grip strength on shoulder muscle activity in breast cancer patients
    Tae-Won Yun, Byoung-Hee Lee
    Physical Therapy Rehabilitation Science.2016; 5(2): 95.     CrossRef
  • The Structural Equation Model on Resilience of Breast Cancer Patients Receiving Chemotherapy
    Jeong Ha Yang, Ok Soo Kim
    Journal of Korean Academy of Nursing.2016; 46(3): 327.     CrossRef
  • Gastric Cancer with Peritoneal Tuberculosis: Challenges in Diagnosis and Treatment
    Amer Saeed Alshahrani, In Seob Lee
    Journal of Gastric Cancer.2016; 16(2): 111.     CrossRef
  • Is there a difference in clinicopathological outcomes of renal tumor between young and old patients? A multicenter matched-pair analysis
    Jeong Ho Kim, Yong Hyun Park, Yong June Kim, Seok Ho Kang, Seok Soo Byun, Sung-Hoo Hong
    Scandinavian Journal of Urology.2016; 50(5): 387.     CrossRef
  • Doctors' Ageism towards the Elderly Cancer Patients: Focusing on Disclosure of Cancer Diagnosis and Explanation on Treatment
    Yeonok Lim, Dae Young Zang, Dae Ro Choi, Seok Yun Kang, Young Suk Park, Hyunsook Yoon, Hyunjoo Lee, Yojin Kim, Ilsung Nam, Kyoungwon Choi
    Korean Journal of Health Promotion.2016; 16(2): 101.     CrossRef
  • The Effect of A Salivation Stimulation Method on Xerostomia in Colon Cancer Patients after Surgery
    Anna Kim, Jeong Sook Park
    Asian Oncology Nursing.2016; 16(2): 75.     CrossRef
  • Quality of life changes during adjuvant chemotherapy in patients with colon cancer
    Seo Hee Lee, Taek-Gu Lee, Moo Jun Baek, Jang Jin Kim, Sung-Su Park, Sang-Jeon Lee
    Korean Journal of Clinical Oncology.2016; 12(1): 60.     CrossRef
  • Preventive effect of fermented red ginseng on cisplatin-induced nephrotoxicity mouse
    Ja-Kyoung Hyun, O Jun Kwon, Joo Young Lee, Seong-Soo Roh, Young-Bae Seo
    Journal of Applied Biological Chemistry.2016; 59(2): 113.     CrossRef
  • Prostate‐specific antigen kinetics following hypofractionated stereotactic body radiotherapy versus conventionally fractionated external beam radiotherapy for low‐ and intermediate‐risk prostate cancer
    Seok Ho Lee, Hun Jung Kim, Woo Chul Kim
    Asia-Pacific Journal of Clinical Oncology.2016; 12(4): 388.     CrossRef
  • Sex Disparity in Gastric Cancer: Female Sex is a Poor Prognostic Factor for Advanced Gastric Cancer
    Hae Won Kim, Jie-Hyun Kim, Beom Jin Lim, HyunKi Kim, Hoguen Kim, Jae Jun Park, Young Hoon Youn, Hyojin Park, Sung Hoon Noh, Jong Won Kim, Seung Ho Choi
    Annals of Surgical Oncology.2016; 23(13): 4344.     CrossRef
  • Resection of Diminutive and Small Colorectal Polyps: What Is the Optimal Technique?
    Jun Lee
    Clinical Endoscopy.2016; 49(4): 355.     CrossRef
  • The Role of Laparoscopic Radical Hysterectomy in Early-Stage Adenocarcinoma of the Uterine Cervix
    Jeong-Yeol Park, Daeyeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
    Annals of Surgical Oncology.2016; 23(S5): 825.     CrossRef
  • Clinical characteristics and potential aetiologies of non‐B non‐C hepatocellular carcinoma in hepatitis B virus endemic area
    Seung Bum Lee, Kang Mo Kim, Jihyun An, Danbi Lee, Ju Hyun Shim, Young‐Suk Lim, Han Chu Lee, Young‐Hwa Chung, Yung Sang Lee
    Liver International.2016; 36(9): 1351.     CrossRef
  • Association of human papillomavirus type 16 and its genetic variants with cervical lesion in Korea
    Jeong Su Park, Sue Shin, Eui‐Chong Kim, Ji Eun Kim, Yong Beom Kim, Sohee Oh, Eun Youn Roh, Jong Hyun Yoon
    APMIS.2016; 124(11): 950.     CrossRef
  • Bowel Preparation Formulations and Salvage Options for Inadequate Preparation
    Jun Lee
    The Korean Journal of Gastroenterology.2016; 68(2): 61.     CrossRef
  • Gallstones and the Risk of Gallbladder Cancer Mortality: A Cohort Study
    Seungho Ryu, Yoosoo Chang, Kyung Eun Yun, Hyun-Suk Jung, Jun Ho Shin, Hocheol Shin
    American Journal of Gastroenterology.2016; 111(10): 1476.     CrossRef
  • Symptom Severity according to the Presence of Depressive and Anxiety Symptoms among Patients with Head and Neck Cancer
    Hyun-Joo Kim, Ok-Hee Cho, Yang-Sook Yoo
    Korean Journal of Adult Nursing.2016; 28(2): 148.     CrossRef
  • Quantification of epidermal growth factor receptor (EGFR) mutation may be a predictor of EGFR‐tyrosine kinase inhibitor treatment response
    Ha Young Park, Hyung Joo Oh, Ki‐Hyun Kim, Tae‐Ok Kim, Cheol‐Kyu Park, Hong‐Jun Shin, Jung‐Hwan Lim, Yong‐Soo Kwon, In‐Jae Oh, Yu‐Il Kim, Sung‐Chul Lim, Young‐Chul Kim, Yoo‐Duk Choi
    Thoracic Cancer.2016; 7(6): 639.     CrossRef
  • A pilot study of concurrent chemoradiotherapy with gemcitabine and cisplatin in patients with locally advanced biliary tract cancer
    Kyong Joo Lee, Seung Woo Yi, Jihye Cha, Jinsil Seong, Seungmin Bang, Si Young Song, Hee Man Kim, Seung Woo Park
    Cancer Chemotherapy and Pharmacology.2016; 78(4): 841.     CrossRef
  • Recent advances in multiple myeloma: a Korean perspective
    Junshik Hong, Jae Hoon Lee
    The Korean Journal of Internal Medicine.2016; 31(5): 820.     CrossRef
  • The Fruit Hull of Gleditsia sinensis Enhances the Anti‐Tumor Effect of cis‐Diammine Dichloridoplatinum II (Cisplatin)
    Kyun Ha Kim, Chang-Woo Han, Seong Hoon Yoon, Yun Seong Kim, Jong-In Kim, Myungsoo Joo, Jun-Yong Choi, Siyaram Pandey
    Evidence-Based Complementary and Alternative Medicine.2016;[Epub]     CrossRef
  • Surgical and obstetrical outcomes after laparoscopic radical trachelectomy and pelvic lymphadenectomy for early cervical cancer
    So-Eun Yoo, Kyeong A So, Seon-Ah Kim, Mi Kyung Kim, Yoo Kyung Lee, In-Ho Lee, Tae-Jin Kim, Ki Heon Lee
    Obstetrics & Gynecology Science.2016; 59(5): 373.     CrossRef
  • Detecting Asymptomatic Recurrence in Early-Stage Endometrial Cancer
    Jung-Yun Lee, Ji Hee Kim, Jung Won Seo, Hee Seung Kim, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song
    International Journal of Gynecological Cancer.2016; 26(8): 1434.     CrossRef
  • Preoperative chemoradiotherapy for elderly patients with locally advanced rectal cancer—a real-world outcome study
    Younak Choi, Jee Hyun Kim, Ji-Won Kim, Jin Won Kim, Keun-Wook Lee, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Changhoon Song, Jae-Sung Kim
    Japanese Journal of Clinical Oncology.2016; 46(12): 1108.     CrossRef
  • The number of retrieved lymph nodes needed for accurate staging differs based on the presence of preoperative chemoradiation for rectal cancer
    Jeonghee Han, Gyoung Tae Noh, Shen Ann Yeo, Chinock Cheong, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim
    Medicine.2016; 95(38): e4891.     CrossRef
  • Cancer-specific incidence rates of tuberculosis
    Gi Hyeon Seo, Min Jae Kim, Soyoung Seo, Boram Hwang, Eugene Lee, Yujin Yun, Minsun Choi, Moonsuk Kim, Jin Won Kim, Eu Suk Kim, Hong Bin Kim, Kyoung-Ho Song
    Medicine.2016; 95(38): e4919.     CrossRef
  • Dietary Patterns for Women With Triple-negative Breast Cancer and Dense Breasts
    Yukyung Go, Minsung Chung, Yongsoon Park
    Nutrition and Cancer.2016; 68(8): 1281.     CrossRef
  • Cause of Death in Korean Men with Prostate Cancer: an Analysis of Time Trends in a Nationwide Cohort
    Jinsung Park, Beomseok Suh, Dong Wook Shin, Jun Hyuk Hong, Hanjong Ahn
    Journal of Korean Medical Science.2016; 31(11): 1802.     CrossRef
  • Preoperative Body Mass Index May Determine the Prognosis of Advanced Gastric Cancer
    Dong Hwan Jun, Beom Jin Kim, Ji Hoon Park, Jae G. Kim, Kyong-Choun Chi, Joong-Min Park, Mi Kyung Kim, Hyun Kang
    Nutrition and Cancer.2016; 68(8): 1295.     CrossRef
  • Effect of Previous Gastrectomy on the Performance of Postoperative Colonoscopy
    Sunghwan Kim, Jeongmin Choi, Tae Han Kim, Seong-Ho Kong, Yun-Suhk Suh, Jong Pil Im, Hyuk-Joon Lee, Sang Gyun Kim, Seung-Yong Jeong, Joo Sung Kim, Han-Kwang Yang
    Journal of Gastric Cancer.2016; 16(3): 167.     CrossRef
  • Prognostic Factors for Node-Negative Advanced Gastric Cancer after Curative Gastrectomy
    Eun Woo Lee, Woo Yong Lee, Ho-Seok Koo
    Journal of Gastric Cancer.2016; 16(3): 161.     CrossRef
  • Is There a Role for Adjuvant Therapy in R0 Resected Gallbladder Cancer?: A Propensity Score-Matched Analysis
    Se-Il Go, Young Saing Kim, In Gyu Hwang, Eun Young Kim, Sung Yong Oh, Jun Ho Ji, Haa-Na Song, Se Hoon Park, Joon Oh Park, Jung Hun Kang
    Cancer Research and Treatment.2016; 48(4): 1274.     CrossRef
  • Moderating Effects of Optimism and Family Support on the Depression of Family Caregivers of Cancer Patients
    Kyoungwon Choi, Dae Ro Choi, Dae Young Zang, Young Suk Park, Seok Yun Kang, Hyunsook Yoon, Yeon Ok Lim, Yojin Kim, Ilsung Nam, Hyen Joo Lee
    Korean Journal of Health Promotion.2016; 16(3): 192.     CrossRef
  • Effects of a Navigation Program for Patients with Newly Diagnosed Gastric Cancer: A Randomized Controlled Trial
    Yeon Seo Hong, Jeong Yun Park, So Hee Kim, Sun A Kim, Yeon Hee Kim
    Asian Oncology Nursing.2016; 16(3): 132.     CrossRef
  • Analysis of NF-κ B and Clinical Prognostic Factors in Clear Cell Renal Cell Carcinoma
    Young Lee, Jeonghyouk Choi, Dong-Gi Lee, Koo Han Yoo, Gyeong Eun Min, Hyung-Lae Lee, Kyu Yeoun Won, Sung-Jig Lim
    The Korean Journal of Urological Oncology.2016; 14(2): 63.     CrossRef
  • A geographical study of thyroid cancer incidence in north-west England following the Windscale nuclear reactor fire of 1957
    Richard J Q McNally, Richard Wakeford, Peter W James, Nermine O Basta, Robert D Alston, Mark S Pearce, Alex T Elliott
    Journal of Radiological Protection.2016; 36(4): 934.     CrossRef
  • Targeting the Phosphatidylinositol-3-kinase Pathway in Gastric Cancer: Can Omics Improve Outcomes?
    Phu Tran, Cham Nguyen, Samuel J. Klempner
    International Neurourology Journal.2016; 20(Suppl 2): S131.     CrossRef
  • A Comparison of Open, Laparoscopic, and Robotic Surgery in the Treatment of Right-sided Colon Cancer
    Jeonghyun Kang, Yoon Ah Park, Seung Hyuk Baik, Seung-Kook Sohn, Kang Young Lee
    Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2016; 26(6): 497.     CrossRef
  • Dietary protein and fat intake in relation to risk of colorectal adenoma in Korean
    Sun Young Yang, Young Sun Kim, Jung Eun Lee, Jueun Seol, Ji Hyun Song, Goh Eun Chung, Jeong Yoon Yim, Sun Hee Lim, Joo Sung Kim
    Medicine.2016; 95(49): e5453.     CrossRef
  • Unkindness Experience of Health Care Provider in Patients with Breast Cancer
    Sue-Kyung Sohn, Ick-Jee Kim, Mi-SunKim Kim, Kyeong-Hee Shin, Min-Suk Lee, Eun-Mee Lee
    Journal of East-West Nursing Research.2016; 22(1): 51.     CrossRef
  • Anal Human Papillomavirus Infection among HIV-Infected Men in Korea
    Chang Hun Lee, Sun Hee Lee, Shinwon Lee, Heerim Cho, Kye-Hyung Kim, Jung Eun Lee, Eun ju Jung, Su jin Lee, Eun Jung Kim, Ki Hyung Kim, Eunsoo Moon, Hong Je Cho, Maria Lina Tornesello
    PLOS ONE.2016; 11(8): e0161460.     CrossRef
  • Timing of Surgical Management of Papillary Thyroid Cancer Diagnosed during Pregnancy
    Yoonseok Kim, Changhoon Lee, Eunae Jae, Youngjin Lee, Jueun Jung, Susun Kim, Mihyang Kim, Eunsuk Lee, Chunsuk Park, Jaemook Park, Hyunwoo Jung, Musil Park, Jaejun Lee, Junmo Ahn, Soo Lee
    International Journal of Thyroidology.2016; 9(2): 168.     CrossRef
  • Postoperative radiotherapy appeared to improve the disease free survival rate of patients with extrahepatic bile duct cancer at high risk of loco-regional recurrence
    Mi Young Kim, Jin Hee Kim, Yonghoon Kim, Sang Jun Byun
    Radiation Oncology Journal.2016; 34(4): 297.     CrossRef
  • Health Behaviors and Associated Sociodemographic Factors in Cervical Cancer Survivors Compared with Matched Non-Cancer Controls
    Boyoung Park, Se Ik Kim, Sang-Soo Seo, Sokbom Kang, Sang-Yoon Park, Myong Cheol Lim, Michael Scheurer
    PLOS ONE.2016; 11(8): e0160682.     CrossRef
  • Weight Change and Associated Factors in Long-Term Breast Cancer Survivors
    Hye-Yeon Koo, Young-Gyun Seo, Mi-Hee Cho, Min-Jung Kim, Ho-Chun Choi, William B. Coleman
    PLOS ONE.2016; 11(7): e0159098.     CrossRef
  • Treatment outcomes after adjuvant radiotherapy following surgery for patients with stage I endometrial cancer
    Jiyoung Kim, Kyung-Ja Lee, Kyung-Ran Park, Boram Ha, Yi-Jun Kim, Wonguen Jung, Rena Lee, Seung Cheol Kim, Hye Sung Moon, Woong Ju, Yun Hwan Kim, Jihae Lee
    Radiation Oncology Journal.2016; 34(4): 265.     CrossRef
  • A Lymph Node Staging System for Gastric Cancer: A Hybrid Type Based on Topographic and Numeric Systems
    Yoon Young Choi, Ji Yeong An, Hitoshi Katai, Yasuyuki Seto, Takeo Fukagawa, Yasuhiro Okumura, Dong Wook Kim, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh, Anthony W.I. Lo
    PLOS ONE.2016; 11(3): e0149555.     CrossRef
  • Physical, Psychological and Social Symptoms, Activity and Education of Children and Adolescents with Acute Lymphoblastic Leukemia Receiving Maintenance Chemotherapy
    Hee Sung Yoon, Kwang Sung Kim, Sun Hee Choi, So Eun Choi, Kyoung A Kim, Kyoung Eon Kim
    Asian Oncology Nursing.2016; 16(4): 169.     CrossRef
  • Acute High-Dose and Chronic Lifetime Exposure to Alcohol Consumption and Differentiated Thyroid Cancer: T-CALOS Korea
    Yunji Hwang, Kyu Eun Lee, Elisabete Weiderpass, Young Joo Park, Young Jun Chai, Hyungju Kwon, Do Joon Park, BeLong Cho, Ho-Chun Choi, Daehee Kang, Sue K. Park, Li Wang
    PLOS ONE.2016; 11(3): e0151562.     CrossRef
  • Pilot Study of a Next-Generation Sequencing-Based Targeted Anticancer Therapy in Refractory Solid Tumors at a Korean Institution
    Hyung Soon Park, Sun Min Lim, Sora Kim, Sangwoo Kim, Hye Ryun Kim, KyuBum Kwack, Min Goo Lee, Joo-Hang Kim, Yong Wha Moon, Masaru Katoh
    PLOS ONE.2016; 11(4): e0154133.     CrossRef
  • Oral Bisphosphonates and Upper Gastrointestinal Cancer Risks in Asians with Osteoporosis: A Nested Case-Control Study Using National Retrospective Cohort Sample Data from Korea
    Sun-Young Jung, Hyun Soon Sohn, Eun-Ja Park, Hae Sun Suh, Ji-Won Park, Jin-Won Kwon, Chi-Ling Chen
    PLOS ONE.2016; 11(3): e0150531.     CrossRef
  • The Delayed Risk Stratification System in the Risk of Differentiated Thyroid Cancer Recurrence
    Aldona Kowalska, Agnieszka Walczyk, Iwona Pałyga, Danuta Gąsior-Perczak, Klaudia Gadawska-Juszczyk, Monika Szymonek, Tomasz Trybek, Katarzyna Lizis-Kolus, Dorota Szyska-Skrobot, Estera Mikina, Stefan Hurej, Janusz Słuszniak, Ryszard Mężyk, Stanisław Góźdź
    PLOS ONE.2016; 11(4): e0153242.     CrossRef
  • UEG Week 2016 Poster Presentations

    United European Gastroenterology Journal.2016; 4(5_suppl): A157.     CrossRef
  • A Comparison of Spatial Pattern Detection Methods for Major Cancer Mortality in Korea
    Jiyu Kim, Myeonggyun Lee, Inkyung Jung
    Asia Pacific Journal of Public Health.2016; 28(6): 539.     CrossRef
  • Survival Analysis of Advanced Non–Small Cell Lung Cancer Patients Treated by Using Wheel Balance Cancer Therapy
    Jongmin Kim, Chong-Kwan Cho, Hwa-Seung Yoo
    Integrative Cancer Therapies.2016; 15(4): 467.     CrossRef
  • Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.) in YD-15 tongue mucoepidermoid carcinoma cells
    HAE NIM LEE, HYE YEON JANG, HYEONG JIN KIM, SEONG AH SHIN, GANG SIK CHOO, YOUNG SEOK PARK, SANG KI KIM, JI YOUN JUNG
    International Journal of Molecular Medicine.2016; 37(4): 939.     CrossRef
  • Preoperative chemoradiotherapy followed by transanal local excision for T3 distal rectal cancer: A case report
    SEUNG-GU YEO
    Experimental and Therapeutic Medicine.2016; 11(4): 1465.     CrossRef
  • Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma
    SONG XU, XIAO-MING YI, CHAO-PENG TANG, JING-PING GE, ZHENG-YU ZHANG, WEN-QUAN ZHOU
    Oncology Reports.2016; 36(1): 10.     CrossRef
  • Characteristics of and risk factors for colorectal neoplasms in young adults in a screening population
    Seung Eun Lee, Hee Bum Jo, Won Gun Kwack, Yun Jin Jeong, Yeo-Jin Yoon, Hyoun Woo Kang
    World Journal of Gastroenterology.2016; 22(10): 2981.     CrossRef
  • Differential diagnosis of breast masses in South Korean premenopausal women using diffuse optical spectroscopic imaging
    Anaïs Leproux, You Me Kim, Jun Won Min, Christine E. McLaren, Wen-Pin Chen, Thomas D. O’Sullivan, Seung-ha Lee, Phil-Sang Chung, Bruce J. Tromberg
    Journal of Biomedical Optics.2016; 21(7): 074001.     CrossRef
  • Celecoxib and sulindac inhibit TGF-β1-induced epithelial-mesenchymal transition and suppress lung cancer migration and invasion via downregulation of sirtuin 1
    Byong-Ki Cha, Young-Suk Kim, Ki-Eun Hwang, Kyung-Hwa Cho, Seon-Hee Oh, Byoung-Ryun Kim, Hong-Young Jun, Kwon-Ha Yoon, Eun-Taik Jeong, Hak-Ryul Kim
    Oncotarget.2016; 7(35): 57213.     CrossRef
  • Relationship between insulin-like growth factor axis gene polymorphisms and clinical outcome in advanced gastric cancer patients treated with FOLFOX
    Sung Yong Oh, Aesun Shin, Seong-Geun Kim, Jung-Ah Hwang, Seung Hyun Hong, Yeon-Su Lee, Hyuk-Chan Kwon
    Oncotarget.2016; 7(21): 31204.     CrossRef
  • Strategies to improve treatment outcome in gastric cancer: A retrospective analysis of patients from two high-volume hospitals in Korea and China
    Kun Yang, Yoon Young Choi, Wei-Han Zhang, Xin-Zu Chen, Mi Kyung Song, Jinae Lee, Bo Zhang, Zhi-Xin Chen, Hyoung-Il Kim, Jia-Ping Chen, Jae-Ho Cheong, Zong-Guang Zhou, Woo Jin Hyung, Jian-Kun Hu, Sung Hoon Noh
    Oncotarget.2016; 7(28): 44660.     CrossRef
  • Downregulation of osteoprotegerin expression in metastatic colorectal carcinoma predicts recurrent metastasis and poor prognosis
    Ahrim Moon, Sung-Im Do, Hyun-Soo Kim, Youn-Wha Kim
    Oncotarget.2016; 7(48): 79319.     CrossRef
  • The Korean guideline for colorectal cancer screening
    Dae Kyung Sohn, Min Ju Kim, Younhee Park, Mina Suh, Aesun Shin, Hee Young Lee, Jong Pil Im, Hyoen-Min Cho, Sung Pil Hong, Baek-hui Kim, Yongsoo Kim, Jeong Wook Kim, Hyun-Soo Kim, Chung Mo Nam, Dong Il Park, Jun Won Um, Soon Nam Oh, Hwan Sub Lim, Hee Jin C
    Journal of the Korean Medical Association.2015; 58(5): 420.     CrossRef
  • The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis
    Kyung Ho Pak, Ara Jo, Hye Ji Choi, Younghee Choi, Hyunki Kim, Jae-Ho Cheong
    BMC Cancer.2015;[Epub]     CrossRef
  • Total and Dietary Calcium Intake and Colorectal Adenoma in Korean Adults
    Ju Eun Seol, Chang Ho Cho, Sung Hi Kim, Jung Eun Lee
    Journal of Cancer Prevention.2015; 20(2): 153.     CrossRef
  • Association of Dietary Vitamin D and Calcium With Genetic Polymorphisms in Colorectal Neoplasia
    Yoon Park, Jeongseon Kim
    Journal of Cancer Prevention.2015; 20(2): 97.     CrossRef
  • The role of surgery in stage IV gastric cancer
    Dong-Seok Han
    Korean Journal of Clinical Oncology.2015; 11(1): 1.     CrossRef
  • Epidemiology of prostate cancer in South Korea
    Hyun Ho Han, Jae Won Park, Joon Chae Na, Byung Ha Chung, Choung-Soo Kim, Woo Jin Ko
    Prostate International.2015; 3(3): 99.     CrossRef
  • Comparison of Quality of Life and Nutritional Status in Gastric Cancer Patients Undergoing Gastrectomies
    Hee-Sook Lim, Gyu-Seok Cho, Yoon-Hyung Park, Soon-Kyung Kim
    Clinical Nutrition Research.2015; 4(3): 153.     CrossRef
  • Evolution of Gastric Cancer Treatment: From the Golden Age of Surgery to an Era of Precision Medicine
    Yoon Young Choi, Sung Hoon Noh, Jae-Ho Cheong
    Yonsei Medical Journal.2015; 56(5): 1177.     CrossRef
  • Identification of occult tumors by whole-specimen mapping in solitary papillary thyroid carcinoma
    Seog Yun Park, Yuh-S Jung, Chang Hwan Ryu, Chang Yoon Lee, You Jin Lee, Eun Kyung Lee, Seok-Ki Kim, Tae Sung Kim, Tae Hyun Kim, Jeyun Jang, Daeyoon Park, Seung Myung Dong, Jae-Goo Kang, Jin Soo Lee, Junsun Ryu
    Endocrine-Related Cancer.2015; 22(4): 679.     CrossRef
  • <i>Helicobacter Pylori</i> Infection and Related Gastrointestinal Diseases
    Chang Seok Bang, Gwang Ho Baik
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Prediction of Cancer Incidence and Mortality in Korea, 2015
Kyu-Won Jung, Young-Joo Won, Chang-Mo Oh, Hyun-Joo Kong, Hyunsoon Cho, Duk Hyoung Lee, Kang Hyun Lee
Cancer Res Treat. 2015;47(2):142-148.   Published online March 17, 2015
DOI: https://doi.org/10.4143/crt.2015.066
AbstractAbstract PDFPubReaderePub
Purpose
For estimation of Korea’s current cancer burden, this study aimed to report on the projected cancer incidence and mortality rates for the year 2015. Materials and Methods Cancer incidence data from 1999 to 2012 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2013 were acquired from Statistics Korea. The cancer incidence in 2015 was projected by fitting a linear regression model to the observed age-specific cancer incidence rates against the observed years and then multiplying the projected age-specific rates by the age-specific population. A similar procedure was used for cancer mortality, except a Joinpoint regression model was used to determine at which year the linear trend changed significantly.
Results
A total of 280,556 new cancer cases and 76,698 cancer deaths are expected to occur in Korea in 2015. The crude incidence rate per 100,000 of all sites combined will likely reach 551.6 and the age-standardized incidence rate, 347.6. The estimated five leading primary cancer incidence sites are the stomach, colorectum, lung, prostate, and liver in men; and thyroid, breast, colorectum, stomach, and lung in women. The projected crude mortality rate of all sites combined and age-standardized rate is 150.8 and 82.4, respectively. Conclusion Cancer is currently one of the foremost public health concerns in Korea, and as the population ages, the nation’s cancer burden will continue to increase.

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Original Articles
Setting a Health Policy Research Agenda for Controlling Cancer Burden in Korea
Sung-In Jang, Kyoung-Hee Cho, Sun Jung Kim, Kwang-Sig Lee, Eun-Cheol Park
Cancer Res Treat. 2015;47(2):149-157.   Published online September 11, 2014
DOI: https://doi.org/10.4143/crt.2013.167
AbstractAbstract PDFPubReaderePub
Purpose
The aim of study was to provide suggestions for prioritizing research in effort to reduce cancer burden in Korea based on a comprehensive analysis of cancer burden and Delphi consensus among cancer experts. Materials and Methods Twenty research plans covering 10 topics were selected based on an assessment of the literature, and e-mail surveys were analyzed using a two-round modified Delphi method. Thirty-four out of 79 experts were selected from four organizations to participate in round one, and 21 experts among them had completed round two. Each item had two questions; one regarding the agreement of the topic as a priority item to reduce cancer burden, and the other about the importance of the item on a nine-point scale. A consensus was defined to be an average lower coefficient of variation with less than 30% in importance. Results Seven plans that satisfied the three criteria were selected as priority research plans for reducing cancer burden. These plans are “research into advanced clinical guidelines for thyroid cancer given the current issue with over-diagnosis,” “research into smoking management plans through price and non-price cigarette policy initiatives,” “research into ways to measure the quality of cancer care,” “research on policy development to expand hospice care,” “research into the spread and management of Helicobacter pylori,” “research on palliative care in a clinical setting,” and “research into alternative mammography methods to increase the accuracy of breast cancer screenings.” Conclusion The seven plans identified in this study should be prioritized to reduce the burden of cancer in Korea. We suggest that policy makers and administrators study and invest significant effort in these plans.

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    Qiaohua Xu, Biyun Chen, Donghui Jin, Li Yin, Yuelong Huang
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    Laura C. Nelson
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    Yong Suk Lee, Hong-Suk Kim, Hyung-Do Kim, Ki-Bong Yoo, Sung-In Jang, Eun-Cheol Park
    Nicotine & Tobacco Research.2016; 18(10): 2013.     CrossRef
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Perceptions of Cancer Risk and Cause of Cancer Risk in Korean Adults
Su Yeon Kye, Eun Young Park, Kyounghee Oh, Keeho Park
Cancer Res Treat. 2015;47(2):158-165.   Published online September 15, 2014
DOI: https://doi.org/10.4143/crt.2014.024
AbstractAbstract PDFPubReaderePub
Purpose
The aims of the present study were to assess the prevalence of perceived risk for cancer; to explore associations between sociodemographics and family history of cancer and perceived cancer risk; to identify perceived cause of cancer risk; and to examine the associations between sociodemographics and family history of cancer and perceived cause of cancer risk. Materials and Methods This cross-sectional study was conducted among 1,009 participants aged 30-69 years, selected from a population-based database in October 2009 through multiple-stratified random sampling. Information was collected about the participants’ perceived cancer risk and perceived cause of cancer risk. Results Overall, 59.5% of the respondents thought they had the chance of developing cancer. Female sex, younger age, lower income, and family history of cancer were positively associated with perceived cancer risk. The most important perceived cause of cancer risk was stress. There was a difference between sociodemographics and family history of cancer and perceived cause of cancer risk. Conclusion Factors affecting perceptions of cancer risk and cause of cancer risk need to be addressed in risk communications. The results provide important directions for the development of educational strategies to promote awareness and self-appraisal of cancer risk and risk factors.

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  • Beliefs on Causes of Cancer in the General Population, and the Association With Risk Perception and Lifestyle in a Multiethnic Setting
    Nur-Nadiatul-Asyikin Bujang, Yek-Ching Kong, Mahmoud Danaee, Murallitharan Munisamy, Ranjit Kaur, Harenthri Devy Alagir Rajah, Hariharan Menon, Shridevi Subramaniam, Kelly Lai Ming Ying, Ros Suzanna Bustamam, Cheng-Har Yip, Nirmala Bhoo Pathy
    JCO Global Oncology.2024;[Epub]     CrossRef
  • Relationship between mental health disorder symptoms and negative cancer perceptions among U.S. adults
    Pierre Fwelo, David Adzrago, Ayooluwatomiwa D. Adekunle, Toluwani E. Adekunle, Ambrose Akinlo, William B. Perkinson
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    Shi Li, Caixia Chen, Hua Zhu, Qi Lin, Zhixian Yu, Sathishkumar V E
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    Miaw Yn Jane Ling, Norfazilah Ahmad, Azimatun Noor Aizuddin, Ghobad Moradi
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    Minji Hwang, Hyun-Soo Zhang, Boyoung Park
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    Ulrike Haug, Oliver Riedel, Constanze Cholmakow-Bodechtel, Louise Olsson
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    Laura C. Nelson
    Medical Anthropology.2017; 36(1): 19.     CrossRef
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    Kawsar Ahmed, Sayed Asaduzzaman, Mamun Ibn Bashar, Goljar Hossain, Touhid Bhuiyan
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Incidence of Primary Spinal Cord, Spinal Meninges, and Cauda Equina Tumors in Korea, 2006-2010
Kyu-Won Jung, Kwang Hyon Park, Johyun Ha, Seung Hoon Lee, Young-Joo Won, Heon Yoo
Cancer Res Treat. 2015;47(2):166-172.   Published online October 30, 2014
DOI: https://doi.org/10.4143/crt.2014.017
AbstractAbstract PDFPubReaderePub
Purpose
Primary spinal cord and appendage tumors (PSCAT) originating from the spinal cord, spinal meninges, and cauda equina are uncommon. Worldwide, population-based cancer registry data are mostly based on malignant tumors only, which means few data are available on PSCATs, including non-malignant tumors. Therefore, the objective of this study was to provide information regarding the incidence of both non-malignant and malignant PSCATs in Korea on a national level. Materials and Methods Incidence of PSCATs was estimated from cases diagnosed between 2006 and 2010 using the National Cancer Incidence Database in Korea. Age-adjusted rates were calculated using the world standard population, and male-to-female rate ratios were calculated by histology type. Results Of all PSCATs registered (n=3,312), 86.6% were non-malignant. The overall age-adjusted incidence of PSCATs was 1.08 per 100,000 person-years, with an incidence of 0.99 per 100,000 in females and 1.15 in males. The most common site of PSCATs was the spinal cord (83.4%), followed by spinal meninges (16.1%) and cauda equina (0.5%). The most common histological type was neurilemmoma (41.3%), followed by meningiomas (20.1%) and ependymomas (7.6%). Men had significantly higher rates than women for ependymomas and lymphomas but had lower rates for meningiomas. Conclusion This study provides the first population-based analysis of PSCATs in Korea.

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    Anibal Rodrigues Neto, Bianca Bicalho, Giovanna Maria Varandas, Adriano Torres Antonucci, Gabriel Gomes Freitas de Castro, Shiro Manoel Shimoakoishi de Arruda, Marcel Schiavini, Lutero Cleuler Moraes dos Santos, Márcio Francisco Lehmann, Francisco Spessat
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    José Alberto Carlos-Escalante, Ángel Antonio Paz-López, Bernardo Cacho-Díaz, Guillermo Pacheco-Cuellar, Gervith Reyes-Soto, Talia Wegman-Ostrosky
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    James J. Yahaya
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    Rachel E. Tsolinas, John F. Burke, Anthony M. DiGiorgio, Leigh H. Thomas, Xuan Duong-Fernandez, Mark H. Harris, John K. Yue, Ethan A. Winkler, Catherine G. Suen, Lisa U. Pascual, Adam R. Ferguson, J. Russell Huie, Jonathan Z. Pan, Debra D. Hemmerle, Vinee
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    Seil Sohn, Jinhee Kim, Chun Kee Chung, Na Rae Lee, Moon Jun Sohn, Sung Hwan Kim
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    Seil Sohn, Jinhee Kim, Chun Kee Chung, Na-Rye Lee, Eunjung Park, Ung-Kyu Chang, Moon Jun Sohn, Sung Hwan Kim
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Treatment Outcomes of Rituximab Plus Hyper-CVAD in Korean Patients with Sporadic Burkitt or Burkitt-like Lymphoma: Results of a Multicenter Analysis
Junshik Hong, Seok Jin Kim, Jae-Sook Ahn, Moo Kon Song, Yu Ri Kim, Ho Sup Lee, Ho-Young Yhim, Dok Hyun Yoon, Min Kyoung Kim, Sung Yong Oh, Yong Park, Yeung-Chul Mun, Young Rok Do, Hun-Mo Ryoo, Je-Jung Lee, Jae Hoon Lee, Won Seog Kim, Cheolwon Suh
Cancer Res Treat. 2015;47(2):173-181.   Published online October 28, 2014
DOI: https://doi.org/10.4143/crt.2014.055
AbstractAbstract PDFPubReaderePub
Purpose
This study was conducted to evaluate outcomes in adult patients with Burkitt lymphoma (BL) or Burkitt-like lymphoma treated with an rituximab plus hyper-CVAD (R-hyper-CVAD) regimen by focusing on tolerability and actual delivered relative dose intensity (RDI).
Materials and Methods
Patients ≥ 20 years of age and pathologically diagnosed with BL or Burkitt-like lymphoma were treated with at least one cycle of R-hyper-CVAD as the first-line treatment in this study. Eligible patients’ case report forms were requested from their physicians to obtain clinical and laboratory data for this retrospective study.
Results
Forty-three patients (median age, 51 years) from 14 medical centers in Korea were analyzed, none of which were infected with human immunodeficiency virus. The majority of patients had advanced diseases, and 24 patients achieved a complete response (75.0%). After a median follow-up period of 20.0 months, 2-year event-free and overall survival rates were 70.9% and 81.4%, respectively. Eleven patients (25.6%) were unable to complete the R-hyper-CVAD regimen, including six patients due to early death. The RDIs of adriamycin, vincristine, methotrexate, and cytarabine were between 60% and 65%, which means less than 25% of patients received greater than 80% of the planned dose of each drug. Poor performance status was related to the lower RDIs of doxorubicin and methotrexate.
Conclusion
R-hyper-CVAD showed excellent treatment outcomes in patients who were suitable for dose-intense chemotherapy. However, management of patients who are intolerant to a dose-intense regimen remains problematic due to the frequent occurrence of treatmentrelated complications.

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The Impact of Molecularly Targeted Treatment on Direct Medical Costs in Patients with Advanced Non-small Cell Lung Cancer
June-Koo Lee, Dong-Wan Kim, Bhumsuk Keam, Tae Min Kim, Se-Hoon Lee, Young-Joo Kim, Dae Seog Heo
Cancer Res Treat. 2015;47(2):182-188.   Published online September 12, 2014
DOI: https://doi.org/10.4143/crt.2013.227
AbstractAbstract PDFPubReaderePub
Purpose
To investigate the impact of targeted treatment on direct medical costs of patients with advanced non-small cell lung cancer (NSCLC). Materials and Methods Medical records of 108 stage IIIB/IV NSCLC patients treated in Seoul National University Hospital between 2003 and 2009, were reviewed to collect medical resources utilization data from the diagnosis of stage IIIB/IV NSCLC to the end of active anti-cancer treatment. The direct medical costs were calculated by multiplying the number of medical resources used by the unit price. All costs were expressed in US dollars for each patient. Results The mean total direct medical costs were $34,732 (standard deviation, 21,168) in the study cohort. The mean total direct medical costs were higher in epidermal growth factor receptor (EGFR) mutation (EGFR MT)–positive patients than EGFR wild-type (EGFR WT) patients ($41,403 vs. $30,146, p=0.005). However, the mean monthly direct medical costs did not differ significantly between EGFR MT–positive patients and EGFR WT patients ($2,120 vs. $2,702, p=0.119) because of the longer duration of active anti-cancer treatment in EGFR MT–positive patients. This discrepancy was mainly attributable to EGFR MT–positive patients’ lower non-chemotherapy costs ($948 vs. $1,522, p=0.007). The total and monthly direct medical costs of ALK fusion–positive patients who did not receive ALK inhibitors did not differ from WT/WT patients. Conclusion This study suggests that the availability of targeted agents for EGFR MT–positive patients lowers the mean monthly medical costs by prolonging survival and diminishing the use of other medical resources, despite the considerable drug costs.

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    Dae Ho Lee, Hiroshi Isobe, Hubert Wirtz, Sabina Bandeira Aleixo, Phillip Parente, Filippo de Marinis, Min Huang, Ashwini Arunachalam, Smita Kothari, Xiting Cao, Nello Donnini, Ann-Marie Woodgate, Javier de Castro
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The Efficacy of External Beam Radiotherapy for Airway Obstruction in Lung Cancer Patients
Jeong Won Lee, Jong Hoon Lee, Hoon-Kyo Kim, Byoung Yong Shim, Ho Jung An, Sung Hwan Kim
Cancer Res Treat. 2015;47(2):189-196.   Published online September 12, 2014
DOI: https://doi.org/10.4143/crt.2013.261
AbstractAbstract PDFPubReaderePub
Purpose
The objective of this study was to evaluate external beam radiotherapy (EBRT) in lung cancer patients who suffer from airway obstruction. Materials and Methods Medical data of 95 patients with a lung mass that obstructed the airway and received EBRT for it were analyzed. Fifty-nine patients (62.1%) had non-small cell lung cancer and 36 patients (37.9%) had small cell lung cancer. Radiotherapy was given at 8 to 45 Gy (median, 30 Gy) in 1 to 15 fractions (median, 10 fractions). The response to EBRT was assessed through changes in radiographic findings and/or subjective symptoms between before and after EBRT. The median follow-up duration was 124 days. The primary end point was the airway-obstruction resolving rate after EBRT. The secondary end points were patient survival and toxic effects of EBRT. Results Improvement of airway obstruction after EBRT on chest X-ray was achieved in 75 of 95 patients (78.9%). The median time for resolving the radiologic findings and/or symptoms of airway obstruction after EBRT was 7 days (range, 1 to 76 days). The 1-year survival rate was significantly higher in responders than non-responders (12.5% vs. 0.0%, p < 0.001). The biologically effective dose of ≥ 39 Gyα/β=10 (p < 0.01) and the longest obstructive lesion of < 6 cm (p=0.04) were significantly associated with a good response to EBRT in resolving the airway obstruction. No one had grade 3 or higher acute and chronic toxicities. Conclusion EBRT is an effective treatment in relieving airway obstruction without severe toxicities in lung cancer patients.

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Nomogram for Predicting Breast Conservation after Neoadjuvant Chemotherapy
Min Kyoon Kim, Wonshik Han, Hyeong-Gon Moon, Soo Kyung Ahn, Jisun Kim, Jun Woo Lee, Ju-Yeon Kim, Taeryung Kim, Kyung-Hun Lee, Tae-Yong Kim, Sae-Won Han, Seock-Ah Im, Tae-You Kim, In Ae Park, Dong-Young Noh
Cancer Res Treat. 2015;47(2):197-207.   Published online September 4, 2014
DOI: https://doi.org/10.4143/crt.2013.247
AbstractAbstract PDFPubReaderePub
Purpose
The ability to accurately predict the likelihood of achieving breast conservation surgery (BCS) after neoadjuvant chemotherapy (NCT) is important in deciding whether NCT or surgery should be the first-line treatment in patients with operable breast cancers. Materials and Methods We reviewed the data of 513 women, who had stage II or III breast cancer and received NCT and surgery from a single institution. The ability of various clinicopathologic factors to predict the achievement of BCS and tumor size reduction to ≤ 3 cm was assessed. Nomograms were built and validated in an independent cohort. Results BCS was performed in 50.1% of patients, with 42.2% of tumors reduced to ≤ 3 cm after NCT. A multivariate logistic regression analysis showed that smaller initial tumor size, longer distance between the lesion and the nipple, absence of suspicious calcifications on mammography, and a single tumor were associated with BCS rather than mastectomy (p < 0.05). Negative estrogen receptor, smaller initial tumor size, higher Ki-67 level, and absence of in situ component were associated with residual tumor size ≤ 3 cm (p < 0.05). Two nomograms were developed using these factors. The areas under the receiver operating characteristic curves for nomograms predicting BCS and residual tumor ≤ 3 cm were 0.800 and 0.777, respectively. The calibration plots showed good agreement between the predicted and actual probabilities. Conclusion We have established a model with novel factors that predicts BCS and residual tumor size after NCT. This model can help in making treatment decisions for patients who are candidates for NCT.

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The Clinical Impact of 21-Gene Recurrence Score on Treatment Decisions for Patients with Hormone Receptor-Positive Early Breast Cancer in Korea
Moo Hyun Lee, Wonshik Han, Jeong Eon Lee, Ku Sang Kim, Heeseung Park, Jongjin Kim, Soo Youn Bae, Hyun Joo Shin, Jong Won Lee, Eun Sook Lee
Cancer Res Treat. 2015;47(2):208-214.   Published online September 11, 2014
DOI: https://doi.org/10.4143/crt.2013.223
AbstractAbstract PDFPubReaderePub
Purpose
The 21-gene (Oncotype DX) recurrence score (RS) assay is useful in predicting the benefits of adjuvant chemotherapy for early breast cancer patients and is widely used in Western countries. However, to date, it has not gained much popularity in East Asia. We analyzed the results from five institutions’ experience from using the 21-gene assay and examined the impact of assay results on decision making of chemotherapy in Korean breast cancer patients and the associations between RS and clinicopathologic characteristics.
Materials and Methods
The 21-gene assay was performed on 212 patients with estrogen receptor-positive early breast cancer in five institutions. Each center made systemic treatment decisions both before and after the knowledge of assay results.
Results
Among the 212 patients, 132 (62.3%) had a low RS of < 18, 60 (28.3%) had an intermediate RS of 18-30, and 20 (9.4%) had a high RS of ≥ 31. Histologic grade, presence of micrometastases, Ki-67, and presence of lymphatic invasion were statistically associated with the RS results. Treatment decisions were changed in 115 of 212 patients (54.2%) in 109 of 212 (51.4%) from chemotherapy plus hormone therapy to hormone therapy, and in six of 212 (2.8%) from hormone therapy to chemotherapy plus hormone therapy.
Conclusion
The 21-gene breast cancer assay proved to have a significant impact on treatment decision- making. The test reduces chemotherapy use in more than 50% of Korean estrogen receptor-positive, early breast cancer patients.

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    Bradley M. Turner, Brian S. Finkelman, David G. Hicks, Numbere Numbereye, Ioana Moisini, Ajay Dhakal, Kristin Skinner, Mary Ann G. Sanders, Xi Wang, Michelle Shayne, Linda Schiffhauer, Hani Katerji, Huina Zhang
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Five-Year Follow-up Study of Monoclonal Gammopathy of Undetermined Significance in a Korean Elderly Urban Cohort
Yun-Gyoo Lee, Soo-Mee Bang, Jeong-Ok Lee, Jin Won Kim, Keun-Wook Lee, Jee Hyun Kim, Jung Han Song, Tae-Hee Kim, Ki Woong Kim, Jong-Seok Lee
Cancer Res Treat. 2015;47(2):215-220.   Published online August 29, 2014
DOI: https://doi.org/10.4143/crt.2013.262
AbstractAbstract PDFPubReaderePub
Purpose
We previously reported the prevalence of monoclonal gammopathy of undetermined significance (MGUS) to be 3.3% among an elderly Korean urban cohort recruited during 2005-2006. Here, we report a 5-year follow-up study of the previously identified MGUS cohort.
Materials and Methods
The 680 participants from the initial cohort were followed-up for a median of 5 years. Sera were collected between 2010 and 2011. Two-step screening was performed with standard serum electrophoresis followed by immunofixation and determination of the serum concentration of monoclonal-protein (M-protein).
Results
Of the 680 participants (21 with MGUS), 348 (51%) agreed to participate in the follow-up study and 10 were found to have MGUS. Among the 21 MGUS patients initially identified, nine were followed-up, six had persistent M-protein, and one patient had progressed to multiple myeloma (progression rate, 1.0%/yr). The M-protein disappeared in the remaining two individuals. Among the 339 participants without MGUS who were followed-up, four developed an M-protein. There was no significant difference in survival with respect to the presence of MGUS (p=0.66).
Conclusion
The 5-year follow-up data show that the natural clinical course of MGUS in Korea is similar to that in Western countries. MGUS was not associated with an increased risk of death over the 5-year study period.

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Radiation-Induced Autophagy Contributes to Cell Death and Induces Apoptosis Partly in Malignant Glioma Cells
Guk Heui Jo, Oliver Bögler, Yong-Joon Chwae, Heon Yoo, Seung Hoon Lee, Jong Bae Park, Youn-Jae Kim, Jong Heon Kim, Ho-Shin Gwak
Cancer Res Treat. 2015;47(2):221-241.   Published online August 29, 2014
DOI: https://doi.org/10.4143/crt.2013.159
AbstractAbstract PDFPubReaderePub
Purpose
Radiation-induced autophagy has been shown to play two different roles, in malignant glioma (MG) cells, cytocidal or cytoprotective. However, neither the role of radiation-induced autophagy for cell death nor the existence of autophagy-induced apoptosis, a well-known cell-death pathway after irradiation, has been verified yet. Materials and Methods We observed both temporal and dose-dependent response patterns of autophagy and apoptosis to radiation in MG cell lines. Additionally, we investigated the role of autophagy in apoptosis through knockdown of autophagy-related proteins. Results Autophagic activity measured by staining of acidic vesicle organelles and Western blotting of LC-3 protein increased in proportion to radiation dose from day 1 to 5 after irradiation. Apoptosis measured by annexin-V staining and Western blotting of cleaved poly(ADP-ribose) polymerase demonstrated relatively late appearance 3 days after irradiation that increased for up to 7 days. Blocking of pan-caspase (Z-VAD-FMK) did not affect apoptosis after irradiation, but silencing of Atg5 effectively reduced radiation-induced autophagy, which decreased apoptosis significantly. Inhibition of autophagy in Atg5 knockdown cells was shown to be beneficial for cell survival. Stable transfection of GFP-LC3 cells was observed after irradiation. Annexin-V was localized in cells bearing GFP-LC3 punctuated spots, indicating autophagy in immunofluorescence. Some of these punctuated GFP-LC3 bearing cells formed conglomerated spots and died in final phase. Conclusion These findings suggest that autophagy appears earlier than apoptosis after irradiation and that a portion of the apoptotic population that appears later is autophagy-dependent. Thus, autophagy is a pathway to cell death after irradiation of MG cells.

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    International Journal of Oncology.2016; 48(6): 2558.     CrossRef
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Novel Methods for Clinical Risk Stratification in Patients with Colorectal Liver Metastases
Ki-Yeol Kim, Nam Kyu Kim, In-Ho Cha, Joong Bae Ahn, Jin Sub Choi, Gi-Hong Choi, Joon Suk Lim, Kang Young Lee, Seung Hyuk Baik, Byung Soh Min, Hyuk Hur, Jae Kyung Roh, Sang Joon Shin
Cancer Res Treat. 2015;47(2):242-250.   Published online September 11, 2014
DOI: https://doi.org/10.4143/crt.2014.066
AbstractAbstract PDFPubReaderePub
Purpose
Colorectal cancer patients with liver-confined metastases are classified as stage IV, but their prognoses can differ from metastases at other sites. In this study, we suggest a novel method for risk stratification using clinically effective factors. Materials and Methods Data on 566 consecutive patients with colorectal liver metastasis (CLM) between 1989 and 2010 were analyzed. This analysis was based on principal component analysis (PCA). Results The survival rate was affected by carcinoembryonic antigen (CEA) level (p < 0.001; risk ratio, 1.90), distribution of liver metastasis (p=0.014; risk ratio, 1.46), and disease-free interval (DFI; p < 0.001; risk ratio, 1.98). When patients were divided into three groups according to PCA score using significantly affected factors, they showed significantly different survival patterns (p < 0.001). Conclusion The PCA scoring system based on CEA level, distribution of liver metastasis, and DFI may be useful for preoperatively determining prognoses in order to assist in clinical decisionmaking and designing future clinical trials for CLM treatment.

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Changes in Arterioportal Shunts in Hepatocellular Carcinoma Patients with Portal Vein Thrombosis Who Were Treated with Chemoembolization Followed by Radiotherapy
Dongryul Oh, Sung Wook Shin, Hee Chul Park, Sung Ki Cho, Do Hoon Lim, Seung Woon Paik
Cancer Res Treat. 2015;47(2):251-258.   Published online October 27, 2014
DOI: https://doi.org/10.4143/crt.2014.011
AbstractAbstract PDFPubReaderePub
Purpose
In this study, we retrospectively investigated the prevalence of arterioportal (AP) shunts in hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT) and evaluated the changes in AP shunts after chemoembolization followed by external beam radiation therapy (EBRT).
Materials and Methods
We analyzed 54 HCC patients with PVTT who were treated with chemoembolization followed by EBRT. EBRT was uniformly delivered at a total dose of 30 to 45 Gy (median, 35 Gy), with a daily dose of 2 to 4.5 Gy. Angiographic images of chemoembolization before and after radiation therapy (RT) were reviewed to investigate the AP shunt.
Results
During the initial session of chemoembolization, 33 of 54 patients (61%) had an AP shunt. After EBRT, 32 out of 33 patients had an additional session of chemoembolization and were evaluated for a change in the AP shunt. The AP shunt decreased in 20 of 32 patients (63%) after chemoembolization followed by EBRT. The 1-year calculated overall survival (OS) rate for all patients was 52.6% and the 2-year OS was 36.4%. The median OS in all patients was 13 months. Patients with AP shunt showed poorer median OS than those without AP shunt, but there was no statistically significant difference (median, 12 months vs. 17 months).
Conclusion
The AP shunt frequently occurs in HCC patients with PVTT. This study suggests that a poor prognosis is associated with an AP shunt. Chemoembolization followed by RT may produce a decrease in AP shunts.

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  • Sorafenib plus drug-eluting bead transarterial chemoembolization for early intrahepatic stage-progressed advanced hepatocellular carcinoma refractory to conventional transarterial chemoembolization
    Wenzhe Fan, Bowen Zhu, Xinlin Zheng, Shufan Yue, Mingjian Lu, Huishuang Fan, Liangliang Qiao, Fuliang Li, Guosheng Yuan, Yanqin Wu, Xinhua Zou, Hongyu Wang, Miao Xue, Jiaping Li
    Journal of Cancer Research and Clinical Oncology.2023; 149(5): 1873.     CrossRef
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    Wenzhe Fan, Jian Guo, Bowen Zhu, Shutong Wang, Lei Yu, Wanchang Huang, Huishuang Fan, Fuliang Li, Yanqin Wu, Yue Zhao, Yu Wang, Miao Xue, Hongyu Wang, Jiaping Li
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  • Is a Technetium-99m Macroaggregated Albumin Scan Essential in the Workup for Selective Internal Radiation Therapy with Yttrium-90? An Analysis of 532 Patients
    Lidia Sancho, Macarena Rodriguez-Fraile, Jose Ignacio Bilbao, Carmen Beorlegui Arteta, Mercedes Iñarrairaegui, Veronica Moran, Bruno Sangro
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Comparison of the Efficacy between Gemcitabine-Cisplatin and Capecitabine-Cisplatin Combination Chemotherapy for Advanced Biliary Tract Cancer
Jieun Lee, Tae Ho Hong, In Seok Lee, Young Kyoung You, Myung Ah Lee
Cancer Res Treat. 2015;47(2):259-265.   Published online September 12, 2014
DOI: https://doi.org/10.4143/crt.2013.230
AbstractAbstract PDFPubReaderePub
Purpose
Gemcitabine-cisplatin combination chemotherapy has been regarded as standard regimen for advanced or metastatic biliary tract cancer (BTC), based on the ABC-02 trial. To date, however, no studies have compared the efficacies of gemcitabine-platinum and fluoropyrimidine- platinum combination chemotherapy, even though fluoropyrimidine has been widely used as a backbone agent for gastrointestinal cancer. This study compared the efficacy and toxicities of gemcitabine-cisplatin (GP) and capecitabine-cisplatin (XP) combination chemotherapy for treatment of advanced BTC. Materials and Methods We examined 49 patients treated with GP and 44 patients treated with XP from October 2009 to July 2012. All patients had unresectable BTC. The GP regimen comprised gemcitabine (1,000 mg/m2, intravenously [IV], days 1 and 8) and cisplatin (75 mg/m2, IV, day 1). The XP regimen comprised capecitabine (1,250 mg/m2 twice a day, peroral, days 1-14) and cisplatin (60 mg/m2, IV, day 1, every three weeks). We analyzed the response rate (RR), time to progression (TTP), overall survival (OS), and toxicity. Results The RRs were 27.3% and 6.1% in the XP and GP arms, respectively. XP resulted in longer TTP (5.2 months vs. 3.6 months, p=0.016), but OS was not statistically different (10.7 months vs. 8.6 months, p=0.365). Both regimens resulted in grade 3-4 hematologic toxicities, but febrile neutropenia was not noted. Grade 3-4 asthenia, stomatitis, and hand-foot syndrome occurred more frequently in the XP arm. Conclusion XP resulted in a superior TTP and RR compared to GP for treatment of advanced BTC, with comparable toxicity. Conduct of prospective large, randomized trials to evaluate the possibility of XP as another standard therapy is warranted.

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    Abisha Nancy Sukumar, Parimala Devi Duraisamy, Prince Makarios Paul. S, Praveena Gopalan, Abiram Angamuthu
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    Ravi Ramjeesingh, Prosanto Chaudhury, Vincent C. Tam, David Roberge, Howard J. Lim, Jennifer J. Knox, Jamil Asselah, Sarah Doucette, Nirlep Chhiber, Rachel Goodwin
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    Takashi Sasaki, Tsuyoshi Takeda, Takeshi Okamoto, Masato Ozaka, Naoki Sasahira
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    Dae-Won Lee, Seock-Ah Im, Yu Jung Kim, Yaewon Yang, Jiyoung Rhee, Im Il Na, Kyung-Hun Lee, Tae-Yong Kim, Sae-Won Han, In Sil Choi, Do-Youn Oh, Jee Hyun Kim, Tae-You Kim, Yung-Jue Bang
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    Jang Han Jung, Hee Seung Lee, Jung Hyun Jo, In Rae Cho, Moon Jae Chung, Seungmin Bang, Seung Woo Park, Si Young Song, Jeong Youp Park
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Gemcitabine Combined with Capecitabine Compared to Gemcitabine with or without Erlotinib as First-Line Chemotherapy in Patients with Advanced Pancreatic Cancer
Jae Yun Lim, Jang Ho Cho, Se Joon Lee, Dong Ki Lee, Dong Sup Yoon, Jae Yong Cho
Cancer Res Treat. 2015;47(2):266-273.   Published online August 29, 2014
DOI: https://doi.org/10.4143/crt.2013.158
AbstractAbstract PDFPubReaderePub
Purpose
The purpose of this study is to retrospectively compare the efficacy and tolerability between three regimens for first-line chemotherapy—gemcitabine plus capecitabine (GEM-X), gemcitabine plus erlotinib (GEM-T), and gemcitabine monotherapy (GEM)—in patients with advanced pancreatic cancer. Materials and Methods There was a total of 127 patients who underwent chemotherapy for pancreatic cancer between January 2007 and November 2011 at our institution. Patients were treated with either GEM (gemcitabine 1,000 mg/m2 on days 1, 8, and 15 every 4 weeks), GEM-T (gemcitabine 1,000 mg/m2 on days 1 and 8 every 3 weeks and erlotinib 100 mg daily), or GEM-X (gemcitabine 1,000 mg/m2 on days 1 and 8 every 3 weeks and capecitabine 850 mg/m2 twice daily for 2 weeks followed by 1 week’s rest) as the first-line treatment. Progression-free survival (PFS), overall survival (OS), objective response rate (ORR), and toxicity were evaluated. Results The patient population was divided into groups depending on their first-line treatment: GEM (n=47), GEM-T (n=44), and GEM-X (n=36). GEM-X significantly improved ORR (21.2% vs. 12.7% and 15.9%), PFS (8.9 vs. 5.2 and 3.9 months; p < 0.001), and OS (12.1 vs. 10.4 and 9.9 months; p = 0.03) compared to GEM and GEM-T, respectively. There were higher incidences of some non-hematologic adverse events with GEM-X and GEM-T compared to GEM, but most were grade 1 or 2. Conclusion GEM-X presented better clinical efficacy and acceptable tolerability than GEM-T and GEM in advanced pancreatic cancers. It is worthy to further investigate which agent has a clinical advantage as a combination drug with gemcitabine in pancreatic cancer and to explore the predictive markers leading to personalize anti-cancer treatment.

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  • Clinical efficacy and safety of erlotinib combined with chemotherapy in the treatment of advanced pancreatic cancer: A meta-analysis
    Xiao-Yan Liu, Hong-Nian Pan, Yue Yu
    World Journal of Gastrointestinal Surgery.2024; 16(3): 921.     CrossRef
  • A Systematic Study of Novel Drug Delivery Mechanisms and Treatment Strategies for Pancreatic Cancer
    Umme Hani, Riyaz Ali M. Osmani, Ayesha Siddiqua, Shadma Wahab, Sadia Batool, Hissana Ather, Norhan Shereba, Ali Alqahtani
    Journal of Drug Delivery Science and Technology.2021; : 102539.     CrossRef
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Prognostic Value of Splenic Artery Invasion in Patients Undergoing Adjuvant Chemoradiotherapy after Distal Pancreatectomy for Pancreatic Adenocarcinoma
Byoung Hyuck Kim, Kyubo Kim, Eui Kyu Chie, Jin-Young Jang, Sun Whe Kim, Sae-Won Han, Do-Youn Oh, Seock-Ah Im, Tae-You Kim, Yung-Jue Bang, Ijin Joo, Sung W. Ha
Cancer Res Treat. 2015;47(2):274-281.   Published online September 12, 2014
DOI: https://doi.org/10.4143/crt.2014.025
AbstractAbstract PDFPubReaderePub
Purpose
The purpose of this study was to evaluate the outcome of adjuvant chemoradiotherapy (CRT) after distal pancreatectomy (DP) in patients with pancreatic adenocarcinoma, and to identify the prognostic factors for these patients.
Materials and Methods
We performed a retrospective review of 62 consecutive patients who underwent curative DP followed by adjuvant CRT between 2000 and 2011. There were 31 men and 31 women, and the median age was 64 years (range, 38 to 80 years). Adjuvant radiotherapy was delivered to the tumor bed and regional lymph nodes with a median dose of 50.4 Gy (range, 40 to 55.8 Gy). All patients received concomitant chemotherapy, and 53 patients (85.5%) also received maintenance chemotherapy. The median follow-up period was 24 months.
Results
Forty patients (64.5%) experienced relapse. Isolated locoregional recurrence developed in 5 patients (8.1%) and distant metastasis in 35 patients (56.5%), of whom 13 had both locoregional recurrence and distant metastasis. The median overall survival (OS) and disease-free survival (DFS) were 37.5 months and 15.4 months, respectively. On multivariate analysis, splenic artery (SA) invasion (p=0.0186) and resection margin (RM) involvement (p=0.0004) were identified as significant adverse prognosticators for DFS. Also, male gender (p=0.0325) and RM involvement (p=0.0007) were associated with a significantly poor OS. Grade 3 or higher hematologic and gastrointestinal toxicities occurred in 22.6% and 4.8% of patients, respectively.
Conclusion
Adjuvant CRT may improve survival after DP for pancreatic body or tail adenocarcinoma. Our results indicated that SA invasion was a significant factor predicting inferior DFS, as was RM involvement. When SA invasion is identified preoperatively, neoadjuvant treatment may be considered.

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  • Prognostic impact of splenic vessel involvement and tumor size in distal pancreatectomy for adenocarcinoma: a retrospective multicentric cohort study
    Dominique Gantois, Théophile Guilbaud, Ugo Scemama, Edouard Girard, Olivier Picaud, Marine Lefevre, Myriam Elgani, Zeinab Hamidou, Vincent Moutardier, Paul Balandraud, Mircea Chirica, Louise Barbier, David Fuks, David Jérémie Birnbaum
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Adjuvant Treatment Modalities, Prognostic Predictors and Outcomes of Uterine Carcinosarcomas
Kemal Gungorduk, Aykut Ozdemir, Ibrahim E. Ertas, Mehmet Gokcu, Elcin Telli, Tufan Oge, Ahmet Sahbaz, Sevil Sayhan, Muzaffer Sanci, Mehmet Harma, Sinan Ozalp
Cancer Res Treat. 2015;47(2):282-289.   Published online September 4, 2014
DOI: https://doi.org/10.4143/crt.2014.009
AbstractAbstract PDFPubReaderePub
Purpose
The purpose of this study is to evaluate the clinicopathological characteristics, treatment, and prognosis of uterine carcinosarcoma (UC). Materials and Methods A retrospective review of three cancer registry databases in Turkey was conducted for identification of patients diagnosed with UC between January 1, 1996, and December 31, 2012. We collected clinicopathological data in order to evaluate factors important in disease- free survival (DFS) and overall survival (OS). Results A total of 66 patients with UC with a median age of 65.0 years were included in the analysis. The median survival time of all patients was 37.5 months and the 5-year OS rate was 59.1%. In early stage patients (I-II) who received adjuvant chemotherapy (CT) with radiation therapy (RT), the median DFS and OS was 44 months and 55 months, respectively, compared to 34.5 months and 36 months, respectively, in patients who received adjuvant RT or CT alone (hazard ratio [HR], 1.4; 95% confidence interval [CI], 0.7 to 3.1 for DFS; p=0.23 and HR, 2.2; 95% CI, 0.9 to 5.3 for OS; p=0.03). In advanced stage patients (III-IV), the median DFS and OS of patients receiving adjuvant RT with CT was 25 months and 38 months, respectively, compared to 23.5 months and 24.5 months, respectively, in patients receiving adjuvant RT or CT alone (HR, 3.1; 95% CI, 0.6 to 16.0 for DFS; p=0.03); (HR, 3.3; 95% CI, 0.7 to 15.0 for OS; p=0.01). In multivariate analysis, advanced International Federation of Gynecology and Obstetrics (FIGO) stage and suboptimal surgery showed significant association with poor OS. Conclusion In patients with early or advanced stage UC, adjuvant CT with RT is associated with improved DFS and OS, as compared to CT or RT alone.

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    Rasiah Bharathan, Stephan Polterauer, Martha C. Lopez-Sanclemente, Hanna Trukhan, Andrei Pletnev, Angel G. Heredia, Maria M. Gil, Irina Bakinovskaya, Alena Dalamanava, Margarita Romeo, Dzmitry Rovski, Laura Baquedano, Luis Chiva, Richard Schwameis, Ignaci
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    Giorgio Bogani, Isabelle Ray-Coquard, Nicole Concin, Natalie Yan Li Ngoi, Philippe Morice, Giuseppe Caruso, Takayuki Enomoto, Kazuhiro Takehara, Hannelore Denys, Domenica Lorusso, Robert Coleman, Michelle M Vaughan, Masashi Takano, Diane Michele Provenche
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  • Influence of Clinical and Surgical Factors on Uterine Carcinosarcoma Survival
    Myriam Gracia, Yusuf Yildirim, Ronalds Macuks, Rosanna Mancari, Patriciu Achimas-Cadariu, Stephan Polterauer, Sara Iacoponi, Ignacio Zapardiel
    Cancers.2023; 15(5): 1463.     CrossRef
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    Clémence Romeo, Olivia Le Saux, Margaux Jacobs, Florence Joly, Gwenael Ferron, Laure Favier, Jean-David Fumet, Nicolas Isambert, Pierre-Emmanuel Colombo, Renaud Sabatier, Ludovic Bastide, Amandine Charreton, Mojgan Devouassoux-Shisheboran, Witold Gertych,
    Cancers.2022; 14(2): 354.     CrossRef
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    Critical Reviews in Oncology/Hematology.2022; 175: 103701.     CrossRef
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    Leana Terblanche, Matthys H. Botha, Sethu Thakachy Subha
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    Kerri Beckmann, Sudarshan Selva-Nayagam, Ian Olver, Caroline Miller, Elizabeth S Buckley, Kate Powell, Dianne Buranyi-Trevarton, Raghu Gowda, David Roder, Martin Oehler
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    K. Hapsari, C. Bhugwandass, G. W. J. van Rijn, A. A. M. van der Wurff, M. van ‘t Veer, D. Boll, M. C. Vos, B. Pijlman, A. Kok, J. M. J. Piek
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    Hyun-Bin Kwak, Jin Park, Han-Uk Kim, Kyung-Hwa Nam, Seok-Kweon Yun
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
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    Guglielmo Mantica, Andrea Benelli, Hilgard Ackermann, Zoliswa Nxumalo, Abdullwahed Solaiman, Federico Dotta, André van der Merwe, Carlo Terrone
    Minerva Urologica e Nefrologica.2019;[Epub]     CrossRef
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    Umran Kucukgoz Gulec, Semra Paydas, Derya Gumurdulu, Ahmet Baris Guzel, Emine Kilic Bagir, Mehmet Ali Vardar
    Indian Journal of Gynecologic Oncology.2019;[Epub]     CrossRef
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    Journal of Gynecologic Oncology.2017;[Epub]     CrossRef
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    Isin Ureyen, Alper Karalok, Derya Akdag Cirik, Tolga Tasci, Zeynep Kestel Gokce, Ipeknur Balin Duzguner, Gokhan Tulunay, Taner Turan
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    Jun Zhu, Hao Wen, Rui Bi, Xiaohua Wu
    Journal of Gynecologic Oncology.2016;[Epub]     CrossRef
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    Hyun Ju Lee, Jeong-Yeol Park, Jong Jin Lee, Mi Hyun Kim, Dae-Yeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
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    Joseph Menczer
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Safety of Fertility-Sparing Surgery in Primary Mucinous Carcinoma of the Ovary
Jung-Yun Lee, Yu Ri Jo, Tae Hun Kim, Hee Seung Kim, Min A Kim, Jae Weon Kim, Noh Hyun Park, Yong-Sang Song
Cancer Res Treat. 2015;47(2):290-305.   Published online August 29, 2014
DOI: https://doi.org/10.4143/crt.2014.004
AbstractAbstract PDFPubReaderePub
Purpose
The aim of this study is to evaluate the safety of fertility-sparing surgery as the treatment for patients with primary mucinous epithelial ovarian cancer.
Materials and Methods
A retrospective study of patients with mucinous ovarian cancer between 1991 and 2010 was performed. The demographics and survival outcomes were compared between patients who underwent fertility-sparing surgery and those who underwent radical surgery.
Results
A total of 110 patients underwent primary surgery. At the time of surgery, tumors appeared to be grossly confined to the ovaries in 90 patients, and evidence of metastasis was definite in 20 patients. Of the 90 patients with tumors that appeared to be grossly confined to the ovaries at surgical exploration, 35 (38.9%) underwent fertility-sparing surgery. The Kaplan- Meier curve and the log rank test showed no difference in either recurrence-free survival (p=0.792) or disease-specific survival (p=0.706) between the two groups. Furthermore, there was no significant difference in recurrence-free survival (p=0.126) or disease-specific survival (p=0.377) between the two groups, even when the analysis was limited to women below the age of 40. In a multivariate Cox model, fertility-sparing surgery had no effect on either recurrence-free survival (recurrence hazard ratio [HR], 1.20; 95% confidence interval [CI], 0.25 to 5.71) or disease-specific survival (death HR, 0.88; 95% CI, 0.17 to 4.60).
Conclusion
Fertility-sparing surgery in primary mucinous cancer grossly confined to the ovaries may be a safe option and one not associated with an increase in recurrence or mortality.

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Postoperative Radiotherapy Alone Versus Chemoradiotherapy in Stage I-II Endometrial Carcinoma: An Investigational and Propensity Score Matching Analysis
Jong Hoon Lee, Hyo Chun Lee, Sung Hwan Kim, Mi Joo Chung, Song Mi Jeong, Sung Jong Lee, Joo Hee Yoon, Dong Choon Park
Cancer Res Treat. 2015;47(2):298-305.   Published online September 15, 2014
DOI: https://doi.org/10.4143/crt.2014.038
AbstractAbstract PDFPubReaderePub
Purpose
The purpose of this study was to compare the results of postoperative adjuvant radiotherapy (RT) and concurrent chemoradiotherapy (CRT) in stage I-II endometrial carcinoma. Materials and Methods We analyzed a total of 64 patients with surgically staged I-II endometrial carcinoma who were treated with postoperative adjuvant RT or concurrent CRT between March 1999 and July 2013. Thirty-two patients who received postoperative RT alone were matched with those who received postoperative CRT (n=32) in accordance to age, stage, and tumor histology. Overall survival and relapse-free survival, as well as toxicity of the RT and CRT arms were evaluated and compared. Results The 5-year overall survival rate was 90.0% for the RT arm and 91.6% for the CRT arm. There was no significant difference in overall survival between the two treatment arms (p=0.798). The 5-year relapse-free survival rate was 87.2% in the RT arm and 88.0% in the CRT arm. Again, no significant difference in relapse-free survival was seen between the two arms (p=0.913). In a multivariate analysis, tumor histology was an independent prognostic factor for relapse-free survival (hazard ratio, 3.67; 95% of CI, 2.34 to 7.65; p=0.045). Acute grade 3 or 4 hematologic toxicities in the CRT arm were significantly higher than in the RT alone arm (6.2% vs. 31.2%, p=0.010). Conclusion Adjuvant pelvic concurrent chemoradioherapy did not show superior results in overall survival and relapse-free survival compared to RT alone in stage I-II endometrial carcinoma.

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    Hee Joong Lee, Banghyun Lee
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    Nataniel H. Lester-Coll, Melissa R. Young, Henry S. Park, Elena S. Ratner, Babak Litkouhi, Shari Damast
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  • 4 Web of Science
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CCL2 Chemokine as a Potential Biomarker for Prostate Cancer: A Pilot Study
Igor Tsaur, Anika Noack, Jasmina Makarevic, Elsie Oppermann, Ana Maria Waaga-Gasser, Martin Gasser, Hendrik Borgmann, Tanja Huesch, Kilian M. Gust, Michael Reiter, David Schilling, Georg Bartsch, Axel Haferkamp, Roman A. Blaheta
Cancer Res Treat. 2015;47(2):306-312.   Published online October 13, 2014
DOI: https://doi.org/10.4143/crt.2014.015
AbstractAbstract PDFPubReaderePub
Purpose
Prostate specific antigen is not reliable in diagnosing prostate cancer (PCa), making the identification of novel, precise diagnostic biomarkers important. Since chemokines are associated with more aggressive disease and poor prognosis in diverse malignancies, we aimed to investigate the diagnostic relevance of chemokines in PCa. Materials and Methods Preoperative and early postoperative serum samples were obtained from 39 consecutive PCa patients undergoing radical prostatectomy. Serum from 15 healthy volunteers served as controls. Concentrations of CXCL12, CXCL13, CX3CL1, CCL2, CCL5, and CCL20 were measured in serum by Luminex. The expression activity of CXCR3, CXCR4, CXCR5, CXCR7, CXCL12, CXCL13, CX3CR1, CXCL1, CCR2, CCR5, CCR6, CCR7, CCL2, and CCL5 mRNA was assessed in tumor and adjacent normal tissue of prostatectomy specimens by quantitative real-time polymerase chain reaction. The associations of these chemokines with clinical and histological parameters were tested. Results The gene expression activity of CCL2 and CCR6 was significantly higher in tumor tissue compared to adjacent normal tissue. CCL2 was also significantly higher in the blood samples of PCa patients, compared to controls. CCL5, CCL20, and CX3CL1 were lower in patient serum, compared to controls. CCR2 tissue mRNA was negatively correlated with the Gleason score and grading. Conclusion Chemokines are significantly modified during tumorigenesis of PCa, and CCL2 is a promising diagnostic biomarker.

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Blockade of Autophagy Aggravates Endoplasmic Reticulum Stress and Improves Paclitaxel Cytotoxicity in Human Cervical Cancer Cells
Li Xu, Jing-Hua Liu, Jing Zhang, Na Zhang, Zan-Hong Wang
Cancer Res Treat. 2015;47(2):313-321.   Published online September 11, 2014
DOI: https://doi.org/10.4143/crt.2013.222
AbstractAbstract PDFPubReaderePub
Purpose
Autophagy is one of the ways to degrade unfolded proteins after endoplasmic reticulum (ER) stress. The purpose of this study is to determine whether a blockade of autophagy leads to aggravated endoplasmic reticulum stress, which then induces cells apoptosis in HeLa cells treated with paclitaxel.
Materials and Methods
Autophagy activation and the proapoptotic effects were characterized using monodansylcadaverine labeling and Hoechest staining, respectively. A Western blot analysis was used to detect the expression of apoptotic and autophagy-related genes. A flow cytometry was used to assess the cell apoptosis ratio.
Results
Paclitaxel exposure induced the aggregation of autophagosomes in the cytoplasms of cervical cancer HeLa cells. The expression of Beclin 1 and LC3 II were upregulated, but p62 was downregulated, which suggests that autophagy was promoted by paclitaxel. On the other hand, the expression of GRP78 obviously increased, suggesting that ER stress was induced after paclitaxel treatment. The cell proliferation assay indicated that a knockdown of Beclin 1 sensitized HeLa cells to paclitaxel. Furthermore, paclitaxel-mediated apoptotic cell death was further potentiated by the pretreatment with autophagy inhibitor chloroquine or small interfering RNA against Beclin 1. These results suggest that an induction of autophagy by paclitaxel may induce cell survival rather than cell death in HeLa cells; moreover, inhibition of autophagy led to an aggravated ER stress and an induction of downstream apoptosis.
Conclusion
Our results reveal autophagy induced by paclitaxel conferred protection of tumor cells against apoptosis, and blockade of autophagy subsequently aggravated ER stress, enhancing the apoptosis associated with paclitaxel treatment in HeLa cells.

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Case Reports
Primary Histiocytic Sarcoma of the Central Nervous System
Hoonsub So, Sun A Kim, Dok Hyun Yoon, Shin Kwang Khang, Jihye Hwang, Chong Hyun Suh, Cheolwon Suh
Cancer Res Treat. 2015;47(2):322-328.   Published online August 29, 2014
DOI: https://doi.org/10.4143/crt.2013.163
AbstractAbstract PDFPubReaderePub
Histiocytic sarcoma is a type of lymphoma that rarely involves the central nervous system (CNS). Its rarity can easily lead to a misdiagnosis. We describe a patient with primary CNS histocytic sarcoma involving the cerebral hemisphere and spinal cord, who had been initially misdiagnosed as demyelinating disease. Two biopsies were necessary before a correct diagnosis was made. A histologic examination showed bizarre shaped histiocytes with larger nuclei and nuclear atypia. The cells were positive for CD68, CD163, and S-100 protein. As a resection was not feasible due to multifocality, he was treated with highdose methotrexate, but showed no response. As a result, he was switched to high dose cytarabine; but again, showed no response. The patient died 2 months from the start of chemotherapy and 8 months from the onset of symptoms. Since few patients with this condition have been described and histopathology is difficult to diagnose, suspicion of the disease is essential.

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Reversible Cerebellar Ataxia Related to Extrapontine Myelinolysis without Hyponatremia after Cisplatin-Based Chemotherapy for Cholangiocarcinoma
Jae Heun Chung, Seung Kug Baik, Su-Hee Cho, Seong-Geun Kim
Cancer Res Treat. 2015;47(2):329-333.   Published online September 11, 2014
DOI: https://doi.org/10.4143/crt.2013.145
AbstractAbstract PDFPubReaderePub
A 60-year-old woman presented with cerebellar signs including dysarthria and ataxia, after intravenous infusion of cisplatin-based chemotherapy. Several blood tests showed mild neutropenia, normocytic normochromic anemia, but no evidence of a marked hyponatremia. Brain magnetic resonance imaging with diffusion-weighted sequences showed hyper-intense signal abnormalities in the extrapontine region, sparing the basis pontis. Here, we report on the case of a patient with reversible cerebellar ataxia related to extrapontine myelinolysis without hyponatremia after treatment with cisplatin-based chemotherapy for cholangiocarcinoma and discuss the literature on cerebellar ataxia in patients who underwent recent chemotherapy for malignancy.

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Successful Treatment of Intractable Bleeding Caused by Radiation-Induced Hemorrhagic Gastritis Using Oral Prednisolone: A Case Report
Hyong Geun Yun, Hong Yong Kim, Do Yeun Kim, Yun Jeong Lim
Cancer Res Treat. 2015;47(2):334-338.   Published online August 28, 2014
DOI: https://doi.org/10.4143/crt.2013.114
AbstractAbstract PDFPubReaderePub
Radiation-induced hemorrhagic gastritis is an intractable and dangerous condition. We describe a 59-year-old female patient with radiation-induced hemorrhagic gastritis. The patient underwent postoperative radiation therapy with a dose of 54 Gy in 30 fractions after a radical operation for a Klatskin tumor. Radiation volume included the gastric antrum. Approximately three months after radiation therapy, she was admitted for melena and anemia. Esophagogastroduodenoscopy showed an area of bleeding in the gastric antrum that was so diffuse that effective laser coagulation was not feasible. After failure of various treatments and transfusion of 7,040 mL of packed red blood cells, we successfully stopped the hemorrhage using oral prednisolone treatment. Based on this case, we think that oral prednisolone treatment can be tried as a first treatment for potentially life-threatening radiation-induced hemorrhagic gastritis.

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Correspondences
Commentary on “Clinical Characteristics and Adequate Treatment of Familial Adenomatous Polyposis Combined with Desmoid Tumors”
Edoardo Virgilio, Francesca Di Gregorio, Genoveffa Balducci
Cancer Res Treat. 2015;47(2):339-340.   Published online February 26, 2015
DOI: https://doi.org/10.4143/crt.2015.038
PDFPubReaderePub

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    Cancer Research and Treatment.2015; 47(2): 341.     CrossRef
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