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Volume 45(3); September 2013
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Review Article
Stereotactic Body Radiotherapy for Early Stage Lung Cancer
Yasushi Nagata
Cancer Res Treat. 2013;45(3):155-161.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.155
AbstractAbstract PDFPubReaderePub
Stereotactic body radiation therapy (SBRT) is a newly developed technique currently in clinical use. SBRT originated from stereotactic radiosurgery for intracranial tumors. SBRT has been widely used clinically for lung cancer. The practice of SBRT demands different kinds of patient fixation, breathing control, target determination, treatment planning, and verifications. The history and current standard technique are reviewed. Clinical studies of lung cancer showed high local control rates with acceptable toxicities. Past and on-going clinical trials are reviewed.

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    Clinical Lung Cancer.2021; 22(5): e678.     CrossRef
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  • Reoxygenation and Repopulation of Tumor Cells after Ablative Hypofractionated Radiotherapy (SBRT and SRS) in Murine Tumors
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  • Radiobiological mechanisms of stereotactic body radiation therapy and stereotactic radiation surgery
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  • Stereotactic Body Radiotherapy Using a Radiobiology-Based Regimen for Stage I Non–Small-Cell Lung Cancer: Five-Year Mature Results
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  • Radiobiological basis of SBRT and SRS
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    International Journal of Clinical Oncology.2014; 19(4): 570.     CrossRef
  • Recent advances in radiation oncology
    Yasushi Nagata
    International Journal of Clinical Oncology.2014; 19(4): 563.     CrossRef
  • Current and emerging strategies to increase the efficacy of ionizing radiation in the treatment of cancer
    Anthony J Berdis
    Expert Opinion on Drug Discovery.2014; 9(2): 167.     CrossRef
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Original Articles
Survival of Korean Adult Cancer Patients by Stage at Diagnosis, 2006-2010: National Cancer Registry Study
Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Chang-Mo Oh, Aesun Shin, Jin-Soo Lee
Cancer Res Treat. 2013;45(3):162-171.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.162
AbstractAbstract PDFPubReaderePub
PURPOSE
Although the cancer stage at diagnosis is the most important prognostic factor for patients' survival, there are few population-based estimates of stage-specific survival outcome, especially in Asian countries. Our study aims to estimate stage-specific survival for Korean patients.
MATERIALS AND METHODS
We analyzed the Korea National Cancer Incidence Database data on 626,506 adult patients aged > or = 20 years, who were diagnosed between 2006 and 2010 with stomach, colorectal, liver, lung, breast, cervix, prostate, and thyroid cancers. Patients were followed up to December 2011, and the 5-year relative survival rates (RSRs) were calculated for gender and age group by Surveillance, Epidemiology, and End Results (SEER) stage at diagnosis.
RESULTS
The 5-year RSRs for all localized-stage cancers, except for lung and liver, exceeded 90% with that for thyroid cancer being the highest at 100.4%. These values for distant stage liver, lung, and stomach cancers were very dismal at 2.5%, 4.8%, and 5.5%, respectively, while it was 69.1% for thyroid cancer, and was in the range of 18.3-36.4% for colorectal, cervix, breast and prostate cancers. Overall, the 5-year RSRs for all cancer types decreased with aging across all the disease stages with exception of prostate cancer, which suggests biologic difference in these cancer types in a young age group. When compared with US SEER data, Korean patients had better stage-specific survival rates for stomach, colorectal, liver, and cervical cancers.
CONCLUSION
Korean cancer patients showed relatively favorable stage distribution and 5-year RSRs, which suggests potential contribution of the national cancer screening program.

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A Phase II Study to Evaluate the Efficacy of Ramosetron, Aprepitant, and Dexamethasone in Preventing Cisplatin-Induced Nausea and Vomiting in Chemotherapy-Naive Cancer Patients
Geundoo Jang, Hun Ho Song, Keon Uk Park, Hyeong Su Kim, Dae Ro Choi, Jung Hye Kwon, Ho Young Kim, Boram Han, Jung Han Kim, Joo Young Jung, Hyo Jung Kim, Dae Young Zang
Cancer Res Treat. 2013;45(3):172-177.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.172
AbstractAbstract PDFPubReaderePub
PURPOSE
Combination therapy with aprepitant, serotonin receptor antagonist, and steroids improves the complete response rate of both acute and delayed chemotherapy-induced nausea and vomiting (CINV). However, it is not known whether ramosetron is suitable for administration in combination with aprepitant. Therefore, we conducted a multicenter, open-label, prospective, phase II study in order to assess the efficacy and tolerability of combination therapy with ramosetron, aprepitant, and dexamethasone (RAD) for prevention of cisplatin-based CINV in chemotherapy-naive patients with solid cancers.
MATERIALS AND METHODS
Forty-one patients with various solid cancers (31 male and 10 female; median age, 59 years) who received treatment with highly emetogenic chemotherapy (median cisplatin dose, 70 mg/m2; range 50 to 75 mg/m2) were enrolled in this study. Oral aprepitant (125 mg on day 1; 80 mg on days 2 and 3), intravenous ramosetron (0.6 mg on day 1), and oral dexamethasone (12 mg on day 1; 8 mg on days 2-4) were administered for prevention of CINV.
RESULTS
The complete response (no emesisand retching and no rescue medication) rate was 94.9% in the acute period (24 hours post-chemotherapy), 92.3% in the delayed period (24-120 hours post-chemotherapy), and 92.3% in the overall period (0-120 hours). The absolute complete response (complete response plus no nausea) rate was 74.4% in the acute period, 51.3% in the delayed period, and 46.2% in the overall period. There were no grade 3 or 4 toxicities related to these antiemetic combinations.
CONCLUSION
RAD regimen is a safe and effective antiemetic treatment for prevention of CINV in patients receiving highly emetogenic chemotherapy.

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How Molecular Understanding Affects to Prescribing Patterns and Clinical Outcome of Gefitinib in Non-small Cell Lung Cancer? 10 Year Experience of Single Institution
Bhumsuk Keam, Dong-Wan Kim, Jin Hyun Park, Jeong-Ok Lee, Tae Min Kim, Se-Hoon Lee, Doo Hyun Chung, Dae Seog Heo
Cancer Res Treat. 2013;45(3):178-185.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.178
AbstractAbstract PDFPubReaderePub
PURPOSE
Gefitinib was introduced in 2002 for treatment of non-small cell lung cancer (NSCLC); however, it is not clear whether its use in daily practice has changed the outcome of patients. The purpose of this study is to evaluate the question of how molecular understanding regarding gefitinib and epidermal growth factor receptor (EGFR) mutation affect the prescribing patterns and clinical outcomes of treatment with gefitinib in NSCLC, in a real practical field.
MATERIALS AND METHODS
We conducted a retrospective analysis of the consecutive database of NSCLC patients who were treated with gefitinib at Seoul National University Hospital between January 2002 and December 2011. Prescribing patterns and clinical outcomes were analyzed by year.
RESULTS
A total of 1,115 NSCLC patients, who received gefitinib at recurred or metastatic setting, were included in this study. Proportion of patients receiving gefitinib, for the first line, showed a gradual increase, from 5.2% in 2002-2003 to 30.6% in 2010-2011. Proportion of patients who underwent EGFR mutation testing showed a rapid increase, from 0.6% in 2004-2005 to 73.5% in 2010-2011. The response rate also showed a gradual increase, from 17.2% in 2002-2003 to 57.1% in 2010-2011 (p<0.001). The median progression-free survival of gefitinib was increased with statistical significance from 2.8 months in 2002-2003 to 9.1 months in 2010-2011 (p<0.001).
CONCLUSION
We demonstrated that molecular understanding and practical use of EGFR mutation testing have resulted in a change in the prescription patterns of gefitinib. Use of an enrichment strategy can lead to improvement in the efficacy of gefitinib in real practice.

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Prognostic Significance of Serum Carcinoembryonic Antigen Normalization on Survival in Rectal Cancer Treated with Preoperative Chemoradiation
Mi-Joo Chung, Su-Mi Chung, Ji-Yoon Kim, Mi-Ryeong Ryu
Cancer Res Treat. 2013;45(3):186-192.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.186
AbstractAbstract PDFPubReaderePub
PURPOSE
The purpose of this retrospective study was to identify factors predictive of survival in rectal cancer patients who received surgery with curative intent after preoperative chemoradiotherapy (CRT).
MATERIALS AND METHODS
Between July 1996 and June 2010, 104 patients underwent surgery for rectal cancer after preoperative CRT. The median dose of radiotherapy was 50.4 Gy (range, 43.2 to 54.4 Gy) for 6 weeks. Chemotherapy was a bolus injection of 5-fluorouracil and leucovorin for the first and last week of radiotherapy (n=84, 77.1%) or capecitabine administered daily during radiotherapy (n=17, 16.3%). Low anterior resection (n=86, 82.7%) or abdominoperineal resection (n=18, 17.3%) was performed at a median 47 days from the end of radiotherapy, and four cycles of adjuvant chemotherapy was administered. The serum carcinoembryonic antigen (CEA) level was checked at initial diagnosis and just before surgery.
RESULTS
After a median follow-up of 48 months (range, 9 to 174 months), 5-year disease free survival (DFS) was 74.5% and 5-year overall survival (OS) was 86.4%. Down staging of T diagnoses occurred in 32 patients (30.8%) and of N diagnoses in 40 patients (38.5%). The CEA change from initial diagnosis to pre-surgery (high-high vs. high-normal vs. normal-normal) was a statistically significant prognostic factor for DFS (p=0.012), OS (p=0.002), and distant metastasis free survival (p=0.018) in a multivariate analysis.
CONCLUSION
Patients who achieve normal CEA level by the time of surgery have a more favorable outcome than those who retain a high CEA level after preoperative CRT. The normalization of CEA levels can provide important information about the prognosis in rectal cancer treatment.

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Impact of Chemoradiation on Prognosis in Stage IVB Cervical Cancer with Distant Lymphatic Metastasis
Hee Seung Kim, Taehun Kim, Eung Seok Lee, Hak Jae Kim, Hyun Hoon Chung, Jae Weon Kim, Yong Sang Song, Noh Hyun Park
Cancer Res Treat. 2013;45(3):193-201.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.193
AbstractAbstract PDFPubReaderePub
PURPOSE
The purpose of this study was to determine whether chemoradiation (CCR) is efficient for improving prognosis, compared with systemic chemotherapy (SC), in patients with stage IVB cervical cancer who have distant lymphatic metastasis.
MATERIALS AND METHODS
Among 2,322 patients with cervical cancer between January 2000 and March 2010, 43 patients (1.9%) had stage IVB disease. After exclusion of 19 patients due to insufficient data and hematogenous metastasis, 24 patients (1%) who received CCR (n=10) or SC (n=14) were enrolled. We compared tumor response, progression-free survival (PFS) and overall survival (OS), and disease recurrence between CCR and SC.
RESULTS
Complete response rates were 60% and 0% after CCR and SC (p<0.01). Grade 3 or 4 leukopenia was more common in patients treated with CCR (24.4% vs. 9.1%, p=0.03), whereas grade 3 or 4 neuropenia was more frequent in those treated with SC (28.4% vs. 11.1%, p=0.03). Development of grade 3 proctitis occurred as a late radiotherapy (RT)-related toxicity in only one patient (10%) treated with CCR. In addition, squamous cell carcinoma and CCR were favorable prognostic factors for improvement of PFS (adjusted hazard ratios [HRs], 0.17 and 0.12; 95% confidence intervals [CIs], 0.04 to 0.80 and 0.03 to 0.61), and only CCR was significant for improvement of OS (adjusted HR, 0.15; 95% CI, 0.02 to 0.90). However, no differences in the rate and pattern of disease recurrence were observed between CCR and SC.
CONCLUSION
CCR may be more effective than SC for improving survival, and can be regarded as a feasible method with some caution regarding late RT-related toxicity for treatment of stage IVB cervical cancer with distant lymphatic metastasis.

Citations

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Role of Postoperative Radiotherapy for Microscopic Margin Involvement in the Squamous Cell Carcinoma of Esophagus
Sanghyuk Song, Eui Kyu Chie, Hak Jae Kim, Chang-Hyun Kang, Young Tae Kim, Joo Hyun Kim, Charn Il Park
Cancer Res Treat. 2013;45(3):202-209.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.202
AbstractAbstract PDFPubReaderePub
PURPOSE
The objective of this study was to assess the effect of postoperative radiotherapy on the outcome of esophageal cancer with microscopically positive resection margin by comparing the results with those of patients with negative resection margin.
MATERIALS AND METHODS
Medical records of 88 patients treated with macroscopic resection followed by postoperative radiotherapy for stage II or III squamous cell carcinoma of the esophagus from June 1984 to March 2008 were reviewed. Twelve patients had received chemotherapy. Patients were classified into two groups based on resection margin status: negative resection margin (group A, n=66) and microscopically positive resection margin (group B, n=22). Median follow-up duration of living patients was 68 months (range, 18 to 115 months). Median total radiation dose of group A and group B was 51.5 Gy (range, 45 to 69 Gy) and 52.1 Gy (range, 45 to 64 Gy), respectively.
RESULTS
Median overall survival and disease-free survival were 15 and 10 months, respectively. The five-year overall survival, disease-free survival, and local control rates for group A and group B were 15.9% and 16.4%, 13.5% and 9.1%, and 76.3% and 69.6%, respectively. No statistically significant difference in terms of overall survival, disease-free survival, and local control (p=0.295, p=0.209, and p=0.731, respectively) was observed between group A and group B. Seven patients experienced toxicity of grade 3 or higher.
CONCLUSION
A significant portion of patients with margin involvement reached long term survival after addition of postoperative radiotherapy. These results suggest a potential role of postoperative radiotherapy, especially for patients with margin involvement.

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Prognostic Role of Interleukin-6, Interleukin-8, and Leptin Levels According to Breast Cancer Subtype
Young Ae Cho, Mi-Kyung Sung, Jee-Young Yeon, Jungsil Ro, Jeongseon Kim
Cancer Res Treat. 2013;45(3):210-219.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.210
AbstractAbstract PDFPubReaderePub
PURPOSE
Inflammation within the tumor microenvironment has been reported to show an association with poor prognosis in breast cancer. However, the associations may differ according to breast cancer subtype. In this study, we investigated the association between inflammation-related markers and breast cancer recurrence according to patients' tumor subtypes.
MATERIALS AND METHODS
This prospective study included 240 patients who underwent surgery for management of newly diagnosed breast cancer. Levels of inflammation-related markers (interleukin [IL]-1beta, IL-6, IL-8, monocyte chemoattractant protein-1 [MCP-1], leptin, and adiponectin) were measured at diagnosis, and the associations between these markers and breast cancer recurrence during a six-year follow-up period were examined using the Kaplan-Meier statistical method.
RESULTS
Overall, inflammation-related markers showed no association with breast cancer recurrence. However, when data were stratified by tumor subtype, higher levels of some mediators showed an association with poor prognosis among patients with particular subtypes. Compared to patients without recurrence, patients with recurrence had higher levels of circulating IL-6 (p=0.024) and IL-8 (p=0.016) only among those with HER2- tumors and had higher levels of leptin (p=0.034) only among those with estrogen receptor (ER)+/progesterone receptor (PR)+ tumors. Results of survival analyses revealed an association of high levels of IL-6 (p=0.016) and IL-8 (p=0.022) with poor recurrence-free survival in patients with HER2- tumors. In addition, higher leptin levels indicated shorter recurrence-free survival time only among patients with ER+/PR+ tumors (p=0.022).
CONCLUSION
We found that certain cytokines could have a differential prognostic impact on breast cancer recurrence according to breast cancer subtype. Conduct of additional large studies will be required in order to elucidate the precise roles of these cytokines in breast cancer progression.

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Evaluation of Prescribing Medications for Terminal Cancer Patients near Death: Essential or Futile
Hye Ran Lee, Seong Yoon Yi, Do Yeun Kim
Cancer Res Treat. 2013;45(3):220-225.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.220
AbstractAbstract PDFPubReaderePub
PURPOSE
The purpose of this study is to evaluate the prescription of essential or futile medications for terminal cancer patients during their final admission.
MATERIALS AND METHODS
We conducted a retrospective review of the medical charts of terminally ill cancer patients admitted to the Hemato-oncology Department of two teaching hospitals from March 1, 2007 to December 31, 2009. Essential medications were based on the drugs listed by the International Association for Hospice and Palliative Care, while futile medications were defined when short-term benefit to patients with respect to survival, quality of life, or symptom control was not anticipated.
RESULTS
A total of 196 patients were included. Among essential medications, strong opioids were the most frequently prescribed drugs during the last admission (62.2% fentanyl, 44.3% morphine), followed by megestrol (46.0%), and metoclopramide (37.2%); 51% of gastric protectors were prescribed with potential futility. Anti-hypertensive and antiglycemic agents were administered to those who experienced arterial blood pressure below 90 mm Hg (47.3%) or presented with a single measurement of fasting glucose below 50 mg/dL (10.7%), respectively. Statins were prescribed to 6.1% (12/196) of patients, and 75% of those prescriptions were regarded as futile.
CONCLUSION
Our data suggest that effective prescription of essential medications and withdrawal from futile medications should be actively reconciled for improvement of a patient's end-of-life care.

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    Tatiana Peralta, Maria Margarida Castel-Branco, Paulo Reis-Pina, Isabel Vitória Figueiredo, Marília Dourado
    BMC Palliative Care.2022;[Epub]     CrossRef
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    Hyeon Sik Yun, Youn Seon Choi, Su Hyun Kim, Yoo Jeong Lee, Jae young Park
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    Barbara Roux, Lucas Morin, Arnaud Papon, Marie-Laure Laroche
    European Geriatric Medicine.2019; 10(3): 463.     CrossRef
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    Patrick M. Zueger, Holly M. Holmes, Gregory S. Calip, Dima M. Qato, A. Simon Pickard, Todd A. Lee
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    Ferraz Gonçalves
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    Adam Todd, Andy Husband, Inga Andrew, Sallie-Anne Pearson, Laura Lindsey, Holly Holmes
    BMJ Supportive & Palliative Care.2017; 7(2): 113.     CrossRef
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    Marina Milic, Anna Foster, Karim Rihawi, Alan Anthoney, Chris Twelves
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  • Prescription and Deprescription of Medication During the Last 48 Hours of Life: Multicenter Study in 23 Acute Geriatric Wards in Flanders, Belgium
    Nele J. Van Den Noortgate, Rebecca Verhofstede, Joachim Cohen, Ruth D. Piers, Luc Deliens, Tinne Smets
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  • Non-beneficial treatments in hospital at the end of life: a systematic review on extent of the problem
    M Cardona-Morrell, JCH Kim, RM Turner, M Anstey, IA Mitchell, K Hillman
    International Journal for Quality in Health Care.2016; 28(4): 456.     CrossRef
  • Deprescription in Advanced Cancer Patients Referred to Palliative Care
    Liliana Oliveira, Marta Oliveira Ferreira, Alexandre Rola, Miguel Magalhães, José Ferraz Gonçalves
    Journal of Pain & Palliative Care Pharmacotherapy.2016; 30(3): 201.     CrossRef
  • Polypharmacy among inpatients aged 70 years or older in Australia
    Ruth E Hubbard, Nancye M Peel, Ian A Scott, Jennifer H Martin, Alesha Smith, Peter I Pillans, Arjun Poudel, Leonard C Gray
    Medical Journal of Australia.2015; 202(7): 373.     CrossRef
  • Prescribing for older people discharged from the acute sector to residential aged‐care facilities
    P. Hopcroft, N. M. Peel, A. Poudel, I. A. Scott, L. C. Gray, R. E. Hubbard
    Internal Medicine Journal.2014; 44(10): 1034.     CrossRef
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Psychosocial Impact of Cancer Patients on Their Family Members
Sun Min Lim, Hyeon Chang Kim, Soohyeon Lee
Cancer Res Treat. 2013;45(3):226-233.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.226
AbstractAbstract PDFPubReaderePub
PURPOSE
A population-based study was conducted in order to examine the characteristics of family members of cancer patients in comparison with the general population and also to evaluate the psychosocial impact of cancer patients on their family members.
MATERIALS AND METHODS
From the Fourth Korea National Health and Nutrition Examination Surveys (KNHANES IV) (2007-2009) dataset, we identified 460 cancer patients and then selected family members of these patients who were aged 20 years or older (n=565). The control group was sampled from members of families without a cancer patient with matching for sex and age (n=2,260). Serial conditional logistic regression models were used for comparison of characteristics between family members of cancer patients and subjects in the control group.
RESULTS
Family members of cancer patients were less employed (57.9% vs. 63.0%, p<0.001), more functionally limited (20.2% vs. 16.5%, p=0.032), and had lower self-rated health (p=0.023) compared with sex and age-matched control subjects. They also had a significantly higher level of stress (79.7% vs. 76.1%, p=0.008), history of depression (12.9% vs. 10.2%, p=0.035), and current depressive symptoms (5.5% vs. 3.5%, p=0.038). However, higher physical activity was reported in family members of cancer patients (13.6% vs. 9.6%, p=0.003) than in control subjects. The presence of a cancer patient in the family showed an association with current depressive symptoms (odds ratio, 1.62; 95% confidence interval, 1.05 to 2.48; p=0.028), however, the association was no longer significant after adjustment for household income, education level, and employment status (p=0.304).
CONCLUSION
Family members of cancer patients are more susceptible to depression, probably due to adverse change in socioeconomic status. Use of multidisciplinary approaches for promotion of psychological health and well-being is essential.

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    Rod Carlo Columbres, Erin Jay G. Feliciano, Kathleen Joy Taleon-Tampo, Katelyn Edelwina Y. Legaspi, Michelle Ann B. Eala, Kenrick Ng, Fumiko Chino, Frederic Ivan L. Ting, Edward Christopher Dee
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  • Financial Sequelae of Cancer for Patients' Family Members and Caregivers: A Focus on the Philippines
    Rod Carlo Columbres, Erin Jay G. Feliciano, Lance Isidore Catedral, Jose Ma. H. Zaldarriaga, Michelle Ann B. Eala, Jerickson Abbie Flores, Enrico D. Tangco, Narjust Florez, Frederic Ivan L. Ting, Edward Christopher Dee
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    Jean-François Stephan, Sani Karam
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    Iago Dillion Lima Cavalcanti, Diogo Timóteo Costa, José Cleberson Santos Soares, Mariane Cajubá de Britto Lira Nogueira
    Journal of Religion and Health.2023; 62(3): 1998.     CrossRef
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    Yun Seo Jang, Na-Young Yoon, Kyungduk Hurh, Eun-Cheol Park, Min Jin Ha
    Journal of Affective Disorders.2023; 333: 482.     CrossRef
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    Yie Lin Lew, Fuad Ismail, Siti Azdiah Abdul Aziz, Noraida Mohamed Shah
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    Li-Ping Wong, Yek-Ching Kong, Nanthini Thevi Bhoo-Pathy, Shridevi Subramaniam, Ros Suzanna Bustamam, Nur Aishah Taib, Gwo-Fuang Ho, Hafizah Zaharah, Matin Mellor, Yin-Ling Woo, Cheng-Har Yip, Nirmala Bhoo-Pathy
    JCO Oncology Practice.2021; 17(4): e548.     CrossRef
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    Valerio Nardone, Alfonso Reginelli, Claudia Vinciguerra, Pierpaolo Correale, Maria Grazia Calvanese, Sara Falivene, Angelo Sangiovanni, Roberta Grassi, Angela Di Biase, Maria Angela Polifrone, Michele Caraglia, Salvatore Cappabianca, Cesare Guida
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    Supanee Klungrit, Sureeporn Thanasilp, Chanokporn Jitpanya
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    European Journal of Oncology Nursing.2019; 43: 101669.     CrossRef
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    Youngdae Cho, Yongwoo Jeon, Sung-In Jang, Eun-Cheol Park
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    Mi Han
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    Kyung-Hyun Choi, Sang Min Park
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Case Reports
A Rare Presentation of Follicular Lymphoma: Cerebellar Involvement, Successfully Treated with a Combination of Radiotherapy and Chemotherapy
Nuri Karadurmus, Selmin Ataergin, Gokhan Erdem, Mustafa Cakar, Ozdes Emer, Sukru Ozaydin, Mustafa Ozturk, Mukerrem Safali, Fikret Arpaci
Cancer Res Treat. 2013;45(3):234-238.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.234
AbstractAbstract PDFPubReaderePub
The central nervous system (CNS) is an important area of involvement for both high-grade, aggressive primary and secondary lymphomas. Although follicular lymphoma represents a low-grade histology, it may rarely present with CNS involvement. Here, we describe a patient diagnosed with follicular lymphoma who was presented with cerebellar involvement.

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  • Follicular lymphoma with secondary central nervous system relapse: a case report and literature review
    Yuri Tsuboi, Misayo Shimizu, Akihiro Kuroda, Takuya Suyama, Masanori Seki, Atsushi Shinagawa
    Oxford Medical Case Reports.2023;[Epub]     CrossRef
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    Furqaan Ahmed Kaji, Nicolás Martinez‐Calle, Vishakha Sovani, Christopher Paul Fox
    British Journal of Haematology.2022; 197(6): 662.     CrossRef
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    B.K. Kleinschmidt-DeMasters, Ahmed Gilani
    Annals of Diagnostic Pathology.2021; 53: 151765.     CrossRef
  • Cerebral Amyloidoma Resulting from Central Nervous System Lymphoplasmacytic Lymphoma: A Case Report and Literature Review
    Geetha Jagannathan, Guldeep Uppal, Kevin Judy, Mark T. Curtis
    Case Reports in Pathology.2018; 2018: 1.     CrossRef
  • Sites of extranodal involvement are prognostic in patients with stage 1 follicular lymphoma
    Aditi Shastri, Murali Janakiram, Ioannis Mantzaris, Yiting Yu, Jaime S. Londono, Amit K. Verma, Stefan K. Barta
    Oncotarget.2017; 8(45): 78410.     CrossRef
  • Follicular Lymphoma Presenting with Leptomeningeal Disease
    Rubens Costa, Ricardo Costa, Renata Costa
    Case Reports in Hematology.2014; 2014: 1.     CrossRef
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  • 96 Download
  • 6 Crossref
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Angiomatoid Fibrous Histiocytoma as a Second Tumor in a Young Adult with Testicular Cancer
Han-Sang Lee, Taewan Kim, Jin-Sook Kim, Hye Ran Lee, Mee Joo, Ji Yeon Park, Seong Yoon Yi
Cancer Res Treat. 2013;45(3):239-243.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.239
AbstractAbstract PDFPubReaderePub
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor, with a low-grade malignant potential, occurring predominantly in children and young adults. Association between AFH and other malignancies has been rarely reported. A 27-year-old man who presented with a palpable abdominal mass was diagnosed as having testicular cancer with multiple liver and lung metastases. At 16 months after chemotherapy, a follow-up computed tomographic scan revealed a supraclavicular mass measuring 3 cm in size, which was suspected to be a recurrence. The patient underwent surgical excision, and the mass was pathologically diagnosed as a AFH. The patient has had no local recurrence and no distant metastasis for 12 months after resection. To the best of our knowledge, this is the first case report of AFH as a second tumor in a patient with testicular cancer.

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    British Journal of Neurosurgery.2023; 37(5): 1069.     CrossRef
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    Mehmet Çetin, Kubra Katipoglu, İlteriş Türk, Şeref Özkara, Kemal Kosemehmetoglu, Pınar Bıçakçıoğlu
    International Journal of Surgical Pathology.2022; 30(6): 662.     CrossRef
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    Gerardo Cazzato, Anna Colagrande, Antonietta Cimmino, Mariella Silecchia, Teresa Lettini, Leonardo Resta, Giuseppe Ingravallo
    Osteology.2021; 1(3): 112.     CrossRef
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    Chee Kiang Tay, Mariko Siyue Koh, Angela Takano, Marie Christine Aubry, William R. Sukov, Andrew L. Folpe
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    Khin Thway, Cyril Fisher
    Archives of Pathology & Laboratory Medicine.2015; 139(5): 674.     CrossRef
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    Ali Yikilmaz, Bo-Yee Ngan, Oscar M. Navarro
    Pediatric Radiology.2015; 45(12): 1796.     CrossRef
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Successful Treatment by Chemotherapy of Pineal Parenchymal Tumor with Intermediate Differentiation: A Case Report
Ji-won Yi, Hyo-jeong Kim, Young-jin Choi, Young-mi Seol, Dong-hwahn Kahng, Yu-yi Choi, Eun-kyoung Park
Cancer Res Treat. 2013;45(3):244-249.   Published online September 30, 2013
DOI: https://doi.org/10.4143/crt.2013.45.3.244
AbstractAbstract PDFPubReaderePub
A 37-year-old male presented with a mass measuring 2.5 cm in size in the midbrain and obstructive hydrocephalus, which had manifested as a headache and dizziness. Magnetic resonance (MR) imaging of the brain showed intermediate enhancement on T1-weighted MR imaging and a high intensity of enhancement on T2-weighted MR. Neurosurgeons performed an occipital craniotomy with partial removal of the tumor and the postoperative diagnosis was a pineal parenchymal tumor with intermediate differentiation. He had undergone irradiation with 54 Gy of radiation on 27 fractions for removal of the remaining tumor approximately one month after surgery. However, in follow-up imaging performed four months after radiotherapy, a remnant mass in the superoposterior aspect of the midbrain was found to have extended to the hypothalamus and the third ventricle. He was treated with six cycles of procarbazine, lomustine, vincristine chemotherapy. At five months since the completion of chemotherapy, the brain MR imaging showed no evidence of any remaining tumor and he no longer displayed any of his initial symptoms.

Citations

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    Cassie Liu, Joseph Carmicheal, Michael J. Baine, Chi Zhang
    Journal of Central Nervous System Disease.2023;[Epub]     CrossRef
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    Tae-Hwan Park, Seung-Ki Kim, Ji Hoon Phi, Chul-Kee Park, Yong Hwy Kim, Sun Ha Paek, Chang-Hyun Lee, Sung-Hye Park, Eun Jung Koh
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  • Pineal parenchymal tumor of intermediate differentiation: a systematic review and contemporary management of 389 cases reported during the last two decades
    Hajime Takase, Reo Tanoshima, Navneet Singla, Yoshihiko Nakamura, Tetsuya Yamamoto
    Neurosurgical Review.2022; 45(2): 1135.     CrossRef
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    Panagiotis Kerezoudis, Yagiz Ugur Yolcu, Nadia N Laack, Michael W Ruff, Soumen Khatua, David J Daniels, Terry C Burns, Sani H Kizilbash
    Neuro-Oncology Advances.2022;[Epub]     CrossRef
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    Nishanth Sadashiva, Harsh Deora, Kirit Arumalla, Shilpa Rao, Jitender Saini, Dhaval Shukla, Vani Santosh
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    Jason M. Beckta, Ranjit S. Bindra
    International Journal of Radiation Oncology*Biology*Physics.2018; 102(3): 488.     CrossRef
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    Yun Jee Kang, Wenya Linda Bi, Adrian M. Dubuc, Louine Martineau, Azra H. Ligon, Aaron L. Berkowitz, Ayal A. Aizer, Eudocia Q. Lee, Keith L. Ligon, Shakti H. Ramkissoon, Ian F. Dunn
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    Tao Yu, Xingwen Sun, Junmei Wang, Xiaohui Ren, Ning Lin, Song Lin
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    Raghvendra Ramdasi, Kanchan Kothari, Naina Goel, Amit Mahore
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