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Volume 44(1); March 2012
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Review Articles
Present Status and Problems on Molecular Targeted Therapy of Cancer
Nagahiro Saijo
Cancer Res Treat. 2012;44(1):1-10.   Published online March 31, 2012
DOI: https://doi.org/10.4143/crt.2012.44.1.1
AbstractAbstract PDFPubReaderePub
Numerous clinical trials of molecular targeted drugs for cancer have been conducted, with remarkable results for certain drugs and accumulation of "negative data" causing a hitch in the development plan for some other compounds. Five recent issues and problems of molecular targeted therapies were discussed critically. Drug discovery and effects against driver mutations (activating mutations) and problems: possibility for circumventing inherent and acquired resistance with the aim of achieving radical cure. Synthetic lethality: reasonable patient selection in individualized treatment strategy. Response rate and progression-free survival improvement with or without overall survival benefit and enhancement of toxicity in bevacizumab therapy: best endpoints for the evaluation of effect of antiangiogenic therapy. Negative data on small-molecule targeted therapy, primarily vascular endothelial growth factor tyrosine kinase inhibitors: loose GO or NO-GO decision criteria for further development of new compounds in early clinical trials. Effect of immunotherapy: difficulty to verify by proof of principle study. We are faced to many questions for the development of efficient personalized therapy. Accumulation of scientific global preclinical and clinical evidences is essential to use these new therapeutic modalities for the improvement of oncologic health care.

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    Dan Le, Karen A. Gelmon
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  • Ligand-Independent Epidermal Growth Factor Receptor Overexpression Correlates with Poor Prognosis in Colorectal Cancer
    Sumi Yun, Yoonjin Kwak, Soo Kyung Nam, An Na Seo, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Hye Seung Lee
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  • Photoswitchable Antimetabolite for Targeted Photoactivated Chemotherapy
    Carlo Matera, Alexandre M. J. Gomila, Núria Camarero, Michela Libergoli, Concepció Soler, Pau Gorostiza
    Journal of the American Chemical Society.2018; 140(46): 15764.     CrossRef
  • Conceptual frameworks of synthetic lethality in clear cell carcinoma of the ovary (Review)
    Hiroshi Kobayashi, Naoki Kawahara, Kenji Ogawa, Yuki Yamada, Kana Iwai, Emiko Niiro, Sachiko Morioka
    Biomedical Reports.2018;[Epub]     CrossRef
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    Hirosato Ebiike, Naoki Taka, Masayuki Matsushita, Masayuki Ohmori, Kyoko Takami, Ikumi Hyohdoh, Masami Kohchi, Tadakatsu Hayase, Hiroki Nishii, Kenji Morikami, Yoshito Nakanishi, Nukinori Akiyama, Hidetoshi Shindoh, Nobuya Ishii, Takehito Isobe, Hiroharu
    Journal of Medicinal Chemistry.2016; 59(23): 10586.     CrossRef
  • Highlights for ESMO 40: celebration review for lifetime achievement awards
    Nagahiro Saijo
    ESMO Open.2016; 1(1): e000010.     CrossRef
  • Comprehensive analysis of RET and ROS1 rearrangement in lung adenocarcinoma
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    E Lee, J Yang, M Ku, N H Kim, Y Park, C B Park, J-S Suh, E S Park, J I Yook, G B Mills, Y-M Huh, J-H Cheong
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  • Multiparametric PET/CT-perfusion does not add significant additional information for initial staging in lung cancer compared with standard PET/CT
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    Ramez N Eskander, Krishnansu S Tewari
    Expert Review of Clinical Pharmacology.2014; 7(5): 613.     CrossRef
  • Beyond angiogenesis blockade: targeted therapy for advanced cervical cancer
    Ramez N. Eskander, Krishnansu S. Tewari
    Journal of Gynecologic Oncology.2014; 25(3): 249.     CrossRef
  • Influence of Ribosomal Protein L39-L in the Drug Resistance Mechanisms of Lacrimal Gland Adenoid Cystic Carcinoma Cells
    Qing Ye, Shao-Feng Ding, Zhi-An Wang, Jie Feng, Wen-Bin Tan
    Asian Pacific Journal of Cancer Prevention.2014; 15(12): 4995.     CrossRef
  • Treatment of Non-small Cell Lung Carcinoma after Failure of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
    Jae Cheol Lee, Seung Hun Jang, Kye Young Lee, Young-Chul Kim
    Cancer Research and Treatment.2013; 45(2): 79.     CrossRef
  • Personalized Oncology in Interventional Radiology
    Nadine Abi-Jaoudeh, Austin G. Duffy, Tim F. Greten, Elise C. Kohn, Timothy W.I. Clark, Bradford J. Wood
    Journal of Vascular and Interventional Radiology.2013; 24(8): 1083.     CrossRef
  • Activation of ERK1/2 and Akt is associated with cisplatin resistance in human lung cancer cells
    Mei Wang, Zi Min Liu, Xiang Chun Li, Yi Tang Yao, Zong Xiu Yin
    Journal of Chemotherapy.2013; 25(3): 162.     CrossRef
  • Interleukin 24: Mechanisms and therapeutic potential of an anti-cancer gene
    Erin L. Whitaker, Valery A. Filippov, Penelope J. Duerksen-Hughes
    Cytokine & Growth Factor Reviews.2012; 23(6): 323.     CrossRef
  • Personalized Medicine
    K.S. Kornman, G.W. Duff
    Journal of Dental Research.2012; 91(7_suppl): S8.     CrossRef
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Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2009
Kyu-Won Jung, Sohee Park, Hyun-Joo Kong, Young-Joo Won, Joo Young Lee, Hong Gwan Seo, Jin-Soo Lee
Cancer Res Treat. 2012;44(1):11-24.   Published online March 31, 2012
DOI: https://doi.org/10.4143/crt.2012.44.1.11
AbstractAbstract PDFPubReaderePub
PURPOSE
This study overviews nationwide cancer statistics, including incidence, mortality, survival, and prevalence, and their trends in Korea based on 2009 cancer incidence data.
MATERIALS AND METHODS
Incidence data from 1993-2009 were obtained from the Korea National Cancer Incidence Database, and vital status was followed through 31 December 2010. Mortality data from 1983-2009 were obtained from Statistics Korea. Crude rates and age-standardized rates for incidence, mortality, and prevalence; and relative survival were calculated.
RESULTS
In total, 192,561 cancer cases and 69,780 cancer deaths were observed during 2009, and 808,503 10-year cancer prevalent cases occurred in Korea as of 1 January 2010. The incidence rate for all cancers combined showed an annual increase of 3.3% from 1999 to 2009.
CONCLUSION
Stomach, liver and cervical cancers have been decreasing and thyroid, breast and colorectal cancers have been increasing at large. In particular, in 2009, colorectal cancer became the third most common cancer in females and for the first time ranked higher than stomach cancer, which had been the long-standing common cancer in Korea. While overall cancer incidence has been rapidly increasing in Korea, age-standardized cancer mortality rates have been declining since 2002, and cancer survival has been improving.

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    Jihwan Park, Yon Ho Jee
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  • Single Port Gastrectomy for Gastric Cancer
    Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim
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  • The clinical utilization of radiation therapy in Korea between 2009 and 2013
    Jin-Kyu Kang, Mi-Sook Kim, Won-Il Jang, Young Seok Seo, Hee Jin Kim, Chul Koo Cho, Hyung Jun Yoo, Eun Kyung Paik, Yu Jin Cha, Hyun Jin Song
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  • Prospective phase II trial of pazopanib plus CapeOX (capecitabine and oxaliplatin) in previously untreated patients with advanced gastric cancer
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  • Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer
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  • Effect of Different Iodine Concentrations on Well-Differentiated Thyroid Cancer Cell Behavior and its Inner Mechanism
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  • A retrospective review of cutaneous metastases at the National Skin Centre Singapore
    Emily Yiping Gan, Martin Tze‐Wei Chio, Wee Ping Tan
    Australasian Journal of Dermatology.2015; 56(1): 1.     CrossRef
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  • Lower maximum standardized uptake value of fluorine-18 fluorodeoxyglucose positron emission tomography coupled with computed tomography imaging in pancreatic ductal adenocarcinoma patients with diabetes
    Kwang Hyun Chung, Joo Kyung Park, Sang Hyub Lee, Dae Wook Hwang, Jai Young Cho, Yoo-Seok Yoon, Ho-Seong Han, Jin-Hyeok Hwang
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  • High liver fibrosis index FIB‐4 is highly predictive of hepatocellular carcinoma in chronic hepatitis B carriers
    Beomseok Suh, Sehhoon Park, Dong Wook Shin, Jae Moon Yun, Hyung‐Kook Yang, Su Jong Yu, Cheong‐Il Shin, Jin‐Soo Kim, Eunmi Ahn, Hyejin Lee, Jin Ho Park, BeLong Cho
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  • Role of charcoal tattooing in localization of recurred papillary thyroid carcinoma: initial experiences
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  • Clinicopathological Characteristics of Serrated Polyposis Syndrome in Korea: Single Center Experience
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  • Therapeutic effect of Active Hexose-Correlated Compound (AHCC) combined with CpG-ODN (oligodeoxynucleotide) in B16 melanoma murine model
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  • Comparison of Social Nicotine Dependence Using the KTSND-K Questionnaire between patients with lung cancer and non-cancer people
    Jin Young Lee, Chul Ho Oak, Tae Won Jang, Maan Hong Jung, Seong Jin Nam, Su Kyung Son, Ji Hyun Lee, Eun Joo Jo, Sang Joon Lee
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  • Preoperative neutrophil-to-lymphocyte ratio is a prognostic factor for overall survival in patients with gastric cancer
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  • The Clinical Significance of the Right Para-Oesophageal Lymph Nodes in Papillary Thyroid Cancer
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  • Incidence, Trends and Epidemiology of Cancers in North West of Iran
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  • HDAC inhibitors induce epithelial-mesenchymal transition in colon carcinoma cells
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    Bang Wool Eom, Keun Won Ryu, Byung-Ho Nam, Yunjin Park, Hyuk-Joon Lee, Min Chan Kim, Gyu Seok Cho, Chan Young Kim, Seung Wan Ryu, Dong Woo Shin, Woo Jin Hyung, Jun Ho Lee, Qing-Yi Wei
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  • A Clinical Analysis of Endoscopic Thyroidectomy via Bilateral Axillo-breast Approach: A 5-year Experience
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  • A Clinical Analysis of Endoscopic Thyroidectomy via Bilateral Axillo-breast Approach: A 5-year Experience
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  • Vegetable Intake, but Not Fruit Intake, Is Associated with a Reduction in the Risk of Cancer Incidence and Mortality in Middle-Aged Korean Men
    Yuni Choi, Jung Eun Lee, Jong-Myon Bae, Zhong-Min Li, Dong-Hyun Kim, Moo-Song Lee, Yoon-Ok Ahn, Myung-Hee Shin
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  • Cytidine Deaminase as a Molecular Predictor of Gemcitabine Response in Patients with Biliary Tract Cancer
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  • Clinical outcomes of a cohort series of patients with hepatocellular carcinoma in a hepatitis B virus‐endemic area
    Hee‐Won Kwak, Joong‐Won Park, Byung‐Ho Nam, Ami Yu, Sang Myung Woo, Tae Hyun Kim, Seong Hoon Kim, Young Hwan Koh, Hyun Beom Kim, Sang Jae Park, Woo Jin Lee, Eun Kyung Hong, Chang‐Min Kim
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  • A nomogram predicting the risks of distant metastasis following postoperative radiotherapy for uterine cervical carcinoma: A Korean radiation oncology group study (KROG 12-08)
    Hyoung Uk Je, Seungbong Han, Young Seok Kim, Joo-Hyun Nam, Hak Jae Kim, Jae Weon Kim, Won Park, Duk-Soo Bae, Jin Hee Kim, So Jin Shin, Juree Kim, Ki-Heon Lee, Mee Sun Yoon, Seok Mo Kim, Ji-Yoon Kim, Won Sup Yoon, Nak Woo Lee, Jin Hwa Choi, Sang-Yoon Park,
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  • Perioperative complication and surgical outcome in patients with spine metastases: Retrospective 200-case series in a single institute
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    Clinical Neurology and Neurosurgery.2014; 122: 80.     CrossRef
  • An essential microRNA maturing microprocessor complex component DGCR8 is up-regulated in colorectal carcinomas
    Bora Kim, Jae-ho Lee, Jong Wook Park, Taeg Kyu Kwon, Seong Kyu Baek, Ilseon Hwang, Shin Kim
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  • Suicide ideation in stomach cancer survivors and possible risk factors
    Ye-Ni Choi, Young-Ae Kim, Young Ho Yun, Sung Kim, Jae-Moon Bae, Young-Woo Kim, Keun Won Ryu, Jun Ho Lee, Jae-Hyung Noh, Tae-Sung Sohn
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  • Does Diabetes Mellitus Influence Standardized Uptake Values of Fluorodeoxyglucose Positron Emission Tomography in Colorectal Cancer?
    Da Yeon Oh, Ji Won Kim, Seong-Joon Koh, Mingoo Kim, Ji Hoon Park, Su Yeon Cho, Byeong Gwan Kim, Kook Lae Lee, Jong Pil Im
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  • Treatment Outcomes of Transurethral Macroplastique Injection for Postprostatectomy Incontinence
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  • Awareness and Ethical Attitudes Toward 'Do-Not-Resuscitate (DNR)' for Cancer Patients
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  • Health‐Related Quality of Life After Robot‐Assisted Distal Gastrectomy in Early Gastric Cancer
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  • EGFR Mutation and Brain Metastasis in Pulmonary Adenocarcinomas
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Original Articles
Prediction of Cancer Incidence and Mortality in Korea, 2012
Kyu-Won Jung, Sohee Park, Young-Joo Won, Hyun-Joo Kong, Joo Young Lee, Hong Gwan Seo, Jin-Soo Lee
Cancer Res Treat. 2012;44(1):25-31.   Published online March 31, 2012
DOI: https://doi.org/10.4143/crt.2012.44.1.25
AbstractAbstract PDFPubReaderePub
PURPOSE
To estimate the current cancer burden in Korea, cancer incidence and mortality rates were projected for the year 2012.
MATERIALS AND METHODS
The cancer incidence data from 1999 to 2009 were obtained from the Korea National Cancer Incidence Database, and the cancer mortality data from 1993 to 2010 were obtained from Statistics Korea. Cancer incidence in 2012 was projected by fitting a linear regression model on observed age-specific cancer incidence rates against observed years, then multiplying the projected age-specific rates by the age-specific population. For cancer mortality, a similar procedure was applied, except that a Joinpoint regression model was used to determine at which year the linear trend significantly changed.
RESULTS
A total of 234,727 new cancer cases and 73,313 cancer deaths are projected to occur in Korea in 2012. For all sites combined, the crude incidence rates are projected to be 465.6 and 459.7, and the age-standardized incidences to be 345.1 and 300.9 per 100,000 respectively for males and females.
CONCLUSION
Cancer has become an important public health concern in Korea, and as the Korean population ages, the cancer burden will continue to increase.

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Prognostic Impact of Polymorphisms in the CASPASE Genes on Survival of Patients with Colorectal Cancer
Jun Young Choi, Jong Gwang Kim, You Jin Lee, Yee Soo Chae, Sang Kyun Sohn, Joon Ho Moon, Byung Woog Kang, Min Kyu Jung, Seong Woo Jeon, Jun Seok Park, Gyu Seog Choi
Cancer Res Treat. 2012;44(1):32-36.   Published online March 31, 2012
DOI: https://doi.org/10.4143/crt.2012.44.1.32
AbstractAbstract PDFPubReaderePub
PURPOSE
This study analyzed potentially functional polymorphisms in CASPASE (CASP) genes and their impact on the prognosis for Korean colorectal cancer patients.
MATERIALS AND METHODS
A total of 397 consecutive patients with curatively resected colorectal adenocarcinoma were enrolled in this study. Genomic DNA from these patients was extracted from fresh colorectal tissue, and the 10 polymorphisms in the CASP3, CASP6, CASP7, CASP8, CASP9, and CASP10 genes were determined using a reverse transcription polymerase chain reaction genotyping assay.
RESULTS
The median patient age was 63 years, and 218 (54.9%) patients had colon cancer, while 179 (45.1%) patients had rectal cancer. Univariate and multivariate survival analysis including pathologic stage, patient age, differentiation, and carcinoembryonic antigen level demonstrated that these polymorphisms were not associated with either disease-free or overall survival.
CONCLUSION
None of the 10 polymorphisms in the CASP genes investigated in this study was found to be an independent prognostic marker for Korean patients with curatively resected colorectal cancer.

Citations

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    Zhengchun Kang, Bingchen Chen, Xiuzhu Ma, Feihu Yan, Zhen Wang
    Frontiers in Molecular Biosciences.2023;[Epub]     CrossRef
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    Xiaoli Fu, Shuai Cheng, Wei Wang, Oumin Shi, Fuxiao Gao, Yong Li, Qi Wang
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    Walid Sabri Hamadou, Rahma Mani, Nouha Bouali, Sawsen Besbes, Violaine Bourdon, Rym El Abed, Yosra Ben Youssef, Véronique Mari, Paul Gesta, Hélène Dreyfus, Valérie Bonadona, Catherine Dugast, Hélène Zattara, Laurence Faivre, Tetsuro Noguchi, Abderrahim Kh
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  • Construction and Characterization of a Synergistic lncRNA–miRNA Network Reveals a Crucial and Prognostic Role of lncRNAs in Colon Cancer
    Bin Zhao, Xiusheng Qu, Xin Lv, Qingdong Wang, Deqiang Bian, Fan Yang, Xingwang Zhao, Zhiwu Ji, Jian Ni, Yan Fu, Guorong Xin, Haitao Yu
    Frontiers in Genetics.2020;[Epub]     CrossRef
  • CASP8 (rs3834129) and CASP3 (rs4647601) polymorphisms in oropharynx cancer risk, tumor cell differentiation, and prognosis in a cohort of the Brazilian population
    Gabriela Arielo Tortorelli, Caroline Torricelli, Juliana Carron, Ericka Francislaine Dias Costa, Leisa Lopes-Aguiar, Bruna Fernandes Carvalho, José Augusto Rinck-Junior, Fernanda Viviane Mariano, Albina Messias Almeida Milani Altemani, Carmen Silvia Passo
    Molecular Biology Reports.2019; 46(6): 6557.     CrossRef
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    Long‑Ci Sun, Hai‑Xin Qian
    Molecular Medicine Reports.2018;[Epub]     CrossRef
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    M Sharifi, A Moridnia
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    Mahdi Fasihi-Ramandi, Abbas Moridnia, Ali Najafi, Mohammadreza Sharifi
    Biomedicine & Pharmacotherapy.2017; 89: 1152.     CrossRef
  • Genetic variants in cell death pathway genes and HBV-related hepatocellular carcinoma among a Chinese Han population
    Fei Liu, Fuqiang Li, Limei Luo, Hanteng Yang, Yonggang Wei, Wentao Wang, Lvnan Yan, Tianfu Wen, Jiayin Yang, Bo Li
    Apoptosis.2017; 22(8): 1035.     CrossRef
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    Yinyin Wu, Juntao Ni, Mingjian Qi, Chengjian Cao, Yuxian Shao, Liangwen Xu, Haiyan Ma, Lei Yang
    Environmental Health.2017;[Epub]     CrossRef
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    Jiarong Cai, Qingjian Ye, Suling Luo, Ze Zhuang, Kui He, Zhen-Jian Zhuo, Xiaochun Wan, Juan Cheng
    Oncotarget.2017; 8(34): 56780.     CrossRef
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    Zhiwei Wu, Ye Li, Shuying Li, Lin Zhu, Guangxiao Li, Zhifu Yu, Xiaojuan Zhao, Jie Ge, Binbin Cui, Xinshu Dong, Suli Tian, Fulan Hu, Yashuang Zhao
    Medical Oncology.2013;[Epub]     CrossRef
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Chemotherapy in Patients Older than or Equal to 75 Years with Advanced Non-small Cell Lung Cancer
Seung Tae Kim, Kyong Hwa Park, Sang Cheul Oh, Jae Hong Seo, Jun Suk Kim, Yeul Hong Kim, Sang Won Shin
Cancer Res Treat. 2012;44(1):37-42.   Published online March 31, 2012
DOI: https://doi.org/10.4143/crt.2012.44.1.37
AbstractAbstract PDFPubReaderePub
PURPOSE
As the number of elderly patients diagnosed with non-small cell lung carcinoma (NSCLC) increases, the number of these patients receiving chemotherapy also increases. However, limited data exists regarding the use of chemotherapy in advanced NSCLC patients who are 75 years of age or older.
MATERIALS AND METHODS
Between May 2002 and October 2008, data for 48 advanced NSCLC patients who were 75 years of age or older who had been treated with chemotherapy were retrospectively analyzed.
RESULTS
The median age of study participants at the time of first line chemotherapy was 76 years (range, 75 to 87 years) and their median Charlson comorbidity index was 2 (range, 1 to 4). Of the total 48 patients, 43 patients (90%) were treated by platinum-based doublet as a first line chemotherapy regimen. Median progression free survival for first line chemotherapy was 5.7 months (95% confidence interval [CI], 4.93 to 6.47 months) with an overall response rate of 33.3%. After first line chemotherapy, only 14 of the 48 patients (29.2%) received second line chemotherapy. The median overall survival (OS) for these patients was 8.2 months (95% CI, 4.44 to 11.96 months). Multivariate analysis results indicated that female gender and having received second-line or more chemotherapy were independent prognostic factors for increased OS for all 48 patients. Charlson Index was not a significant independent prognostic factor for survival. There were 9 treatment related deaths due to infectious causes (18.8%).
CONCLUSION
Patients 75 years of age or older with advanced NSCLC may obtain clinical benefit from the administration of platinum-based doublet or single agent chemotherapy. However, oncologists must consider the aspect of safety in relation to the clinical benefits when managing this patient group.

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Weekly Gemcitabine and Docetaxel in Refractory Soft Tissue Sarcoma: A Retrospective Analysis
Ha-young Lee, Sang Joon Shin, Hyo Song Kim, Soo Jung Hong, Jung Woo Han, Seung Taek Lim, Jae Kyung Roh, Sun Young Rha
Cancer Res Treat. 2012;44(1):43-49.   Published online March 31, 2012
DOI: https://doi.org/10.4143/crt.2012.44.1.43
AbstractAbstract PDFPubReaderePub
PURPOSE
The combination of gemcitabine and docetaxel (GD) is used to effectively treat patients with soft tissue sarcoma (STS). It is widely considered that the conventional doses used are too high for long term use and many patients must discontinue GD treatment due to its toxicity. Therefore, to determine the appropriate dose meeting acceptable efficacy results, while minimizing toxic side effects, we treated patients with a weekly infusion of GD (weekly GD).
MATERIALS AND METHODS
A total of 22 patients presenting a variety of STSs were treated at Yonsei Cancer Center. All patients had metastatic or recurrent cancer and had previously received doxorubicin and ifosfamide combination chemotherapy. In all cases, gemcitabine (1,000 mg/m2) and docetaxel (35 mg/m2) were administered intravenously on days 1 and 8 of a 21-day cycle. We retrospectively reviewed the medical records of these patients.
RESULTS
The response rate was 4.5%, with one patient diagnosed with leiomyosarcoma having a partial response, and the disease control rate was 40.9%. The median progression-free survival (PFS) duration was 2.7 months and the PFS was correlated with the treatment response to a weekly GD. The median overall survival (OS) duration was 7.8 months and the OS was correlated with histology. There was no significant difference in OS between patients who received weekly GD as a 2nd line chemotherapy and those who received 3rd line or more. Treatment was generally well tolerated.
CONCLUSION
Weekly GD was well tolerated and showed moderate efficacy, indicating that this could be a reasonable option as a salvage treatment for metastatic STS.

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    Tae Hun Kim, Ki Hyuk Sung, So Hak Chung
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Correlation of AR, EGFR, and HER2 Expression Levels in Prostate Cancer: Immunohistochemical Analysis and Chromogenic In Situ Hybridization
Kwang Hyun Baek, Min Eui Hong, Yoon Yang Jung, Chung Hun Lee, Tae Jin Lee, Eon Sub Park, Mi Kyung Kim, Jae Hyung Yoo, Soo Whan Lee
Cancer Res Treat. 2012;44(1):50-56.   Published online March 31, 2012
DOI: https://doi.org/10.4143/crt.2012.44.1.50
AbstractAbstract PDFPubReaderePub
PURPOSE
The androgen receptor (AR) plays a central role in prostate cancer. Evidence from several groups indicates that epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) may enhance AR activity in prostate cancer cell lines. This study was designed to investigate the protein expression of AR, EGFR, and HER2 and to determine whether the EGFR and HER2 genes are amplified in prostate cancer tissues.
MATERIALS AND METHODS
The protein expression levels of AR, EGFR, and HER2 in a tissue microarray block of 66 prostate cancer samples were investigated by immunohistochemical analysis and chromogenic in situ hybridization was used to determine whether the EGFR and HER2 genes were amplified in these tissues.
RESULTS
The AR and EGFR proteins were expressed in 59.1% and 40.9% of prostate cancers, respectively, but their expression levels were not significantly associated with clinicopathologic factors. Of the cases in which tissues were negative for EGFR protein expression, 69.2% were positive for AR protein expression; however, AR protein expression was significantly reduced (44.4%) in tissues in which EGFR protein was expressed. HER2 expression was detected in only 1 case (1.5%). No amplification of the EGFR or HER2 genes was found in prostate cancer specimens.
CONCLUSION
This study was limited by small number of subjects, but it can still be inferred that the expression levels of the AR and EGFR proteins are inversely correlated in prostate cancer patients. The potential utility of EGFR and HER2 as prognostic factors or therapeutic targets warrants further study.

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Immunohistochemical Expression of DCUN1D1 in Non-small Cell Lung Carcinoma: Its Relation to Brain Metastasis
Jinyoung Yoo, Seong-Hak Lee, Kwang-Il Lym, Sonya Youngju Park, Seung-Ho Yang, Chang-Young Yoo, Ji-Han Jung, Seok-Jin Kang, Chang-Suk Kang
Cancer Res Treat. 2012;44(1):57-62.   Published online March 31, 2012
DOI: https://doi.org/10.4143/crt.2012.44.1.57
AbstractAbstract PDFPubReaderePub
PURPOSE
Non-small cell lung carcinoma (NSCLC) comprises 75-85% of all lung cancers, and approximately 25% of all NSCLC patients develop brain metastasis. There are no reliable markers for predicting in which patients this metastasis will occur. DCUN1D1, also known as squamous cell carcinoma-related oncogene, is associated with tumor progression and poor outcomes in NSCLC. The objective of this study was to investigate the role of DCUN1D1 expression in cases of brain metastasis due to NSCLC.
MATERIALS AND METHODS
Primary tumor samples from a total of 71 cases of NSCLC, either with (n=40) or without (n=31) brain metastasis, were evaluated for DCUN1D1 expression by immunohistochemistry analysis.
RESULTS
DCUN1D1 expression was detected in 16 patients (23%) and tended to correlate with T classification (15% of T1-2 tumors vs. 30% of T3-4 tumors, p=0.083). DCUN1D1 expression was significantly associated with tumor stage. It was observed in none of the patients with stage I disease, 10% of those with stage II disease, and 29% with stage III disease (p=0.009). In addition, 14 of 16 DCUN1D1-positive patients resulted in brain metastasis (p=0.01). The odds ratio of brain metastasis for patients with DCUN1D1 expression was 3.112 (p=0.009).
CONCLUSION
DCUN1D1 expression may play a role in tumor progression and development of brain metastasis in patients with NSCLC. Evaluation of DCUN1D1 expression may provide assistance in identifying those patients who are at higher risk for brain metastasis.

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    Molecular Medicine.2016; 22(1): 32.     CrossRef
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    Zhaojing Jiang, Qiancheng Song, Rong Zeng, Jing Li, Jingyu Li, Xiaochun Lin, Xing Chen, Jiren Zhang, Yanfang Zheng
    Oncotarget.2016; 7(29): 45622.     CrossRef
  • Value of Oncogenes for the Prediction of Brain Metastases at Initial Diagnosis: A Review of Published Data
    Qian Huang, Xuenong Ouyang
    The International Journal of Biological Markers.2014; 29(4): 291.     CrossRef
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    Masaki Hanibuchi, Sun-Jin Kim, Isaiah J. Fidler, Yasuhiko Nishioka
    The Journal of Medical Investigation.2014; 61(3.4): 241.     CrossRef
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    Qian Huang, Xuenong Ouyang
    Cancer Epidemiology.2013; 37(5): 703.     CrossRef
  • Coamplification and Cooperation: Toward Identifying Biologically Relevant Oncogenes
    Guochang Huang, Bhuvanesh Singh
    Clinical Cancer Research.2013; 19(20): 5549.     CrossRef
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Case Reports
Five Cases Report of Solid Tumor Synchronously with Hematologic Malignancy
Yuehong Cui, Tianshu Liu, Yuhong Zhou, Yuan Ji, Yingyong Hou, Wen Jin, Yi Feng
Cancer Res Treat. 2012;44(1):63-68.   Published online March 31, 2012
DOI: https://doi.org/10.4143/crt.2012.44.1.63
AbstractAbstract PDFPubReaderePub
The reported incidence of synchronous multiple primary cancer (SMPC) is rare, and it is even less common to observe synchronous solid tumor with a hematological malignancy. We report five cases of solid tumor presented synchronously with hematological malignancy, all observed within a 2 year period at the oncology department of a university hospital in Shanghai, China. These individual cases included lung adenocarcinoma with chronic myelogenous leukemia, colon cancer with solitary plasmocytoma, gastric adenocarcinoma with diffuse large B cell non-Hodgkin's lymphoma, lung adenocarcinoma with multiple myeloma, and colon cancer with diffuse large B cell non-Hodgkin's lymphoma. It is challenging to therapeutically control the biological behavior of concurrent multiple primary tumors, and there is no standard treatment for such rare conditions. In this paper we discuss these five cases of SMPC and their treatments.

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    Indian Journal of Medical and Paediatric Oncology.2024; 45(05): 439.     CrossRef
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    Indian Journal of Pathology and Microbiology.2024; 67(2): 390.     CrossRef
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    Lai-Jun Deng, Yang Dong, Mi-Mi Li, Chang-Gang Sun
    World Journal of Clinical Cases.2023; 11(15): 3643.     CrossRef
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    Cong Wang, Yamei Shen, Yuxia Zhang, Fahui Guo, Qian Li, Huahua Zhang, Xueping Han, Haitao Zhao, Zilong Yang
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports
    Rafael Parra-Medina, Franky Rocha, Juan Pablo Castañeda-González, Paula Moreno-Lucero, Luis Veloza, Alfredo E. Romero-Rojas
    Medicine.2022; 101(28): e28988.     CrossRef
  • Unusual Synchronous Association of Solid Tumors with Hematological Malignancies in Multiple Primary Cancers: Case Series and Literature Review
    Aboelkhair Al-Gahmi, Mohammed Alhuthali, Mohammad Alrehaili, Badee Baltow, Emad Tashkandi
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  • Coincidence of three solid tumors in a patient with multiple myeloma
    Muzaffer Keklik, Serdar Sivgin, Kemal Deniz, Halit Karaca, Olgun Kontas, Suleyman Balkanli, Celalettin Eroglu, Ummuhan Abdulrezzak, Gulfugan Kuzu, Leylagul Kaynar, Mustafa Cetin, Ali Unal, Bulent Eser
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A Case of Non-Hodgkin's Lymphoma in Patient with Coombs' Negative Hemolytic Anemia and Idiopathic Thrombocytopenic Purpura
So Yeon Park, Soyon Kim, Eun Sil Kim, Soon Uk Choi, Hee Jae Hyun, Ju Young Ahn, Ju Hyoung Lee, Seo Hee Ryu, Jae Hyun Park, Gyeong In Lee, Hyo Jin Lee
Cancer Res Treat. 2012;44(1):69-72.   Published online March 31, 2012
DOI: https://doi.org/10.4143/crt.2012.44.1.69
AbstractAbstract PDFPubReaderePub
Coombs' negative autoimmune hemolytic anemia (AIHA) is a rare disease which shares similar clinical and hematological features with Coombs' positive AIHA, but its exact frequency remains unknown. There have been few reports of idiopathic thrombocytopenic purpura (ITP) and Coombs' negative AIHA associated with other lymphoproliferative disorders (LPDs). Since there is a well known association between LPDs and autoimmune phenomena, it is important to investigate the possibility of an underlying malignancy. We report a case of ITP and Coombs' negative AIHA associated with diffuse large B-cell lymphoma.

Citations

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  • Treatment of Secondary Immune Thrombocytopenia with Non-Hodgkin Lymphoma: A Case Report and Literature Review
    Yuya Kurihara, Kazuki Taoka, Eri Takagi, Kazuhiro Toyama, Kumi Nakazaki, Mineo Kurokawa
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    Koya Ono, Yasushi Onishi, Masahiro Kobayashi, Satoshi Ichikawa, Shunsuke Hatta, Shotaro Watanabe, Yoko Okitsu, Noriko Fukuhara, Ryo Ichinohasama, Hideo Harigae
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    Yuzuru Hosoda, Hiroshi Hagino, Norihiko Hino, Toru Motokura
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    Tohru Takahashi, Yumiko Maruyama, Mayuko Saitoh, Hideto Itoh, Mitsuru Yoshimoto, Masayuki Tsujisaki, Masato Nakayama
    Internal Medicine.2016; 55(20): 2951.     CrossRef
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    M.S. Karafin, G.A. Denomme, M. Schanen, J.L. Gottschall
    Immunohematology.2015; 31(3): 108.     CrossRef
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