Cancer Research and Treatment

Volume 36(5); October 2004

Review Article

Transcription Factors in the Cellular Signaling Network as Prime Targets of Chemopreventive Phytochemicals: Young-Joon Surh; Cancer Res Treat. 2004;36(5):275-286. Published online October 30, 2004; DOI: https://doi.org/10.4143/crt.2004.36.5.275

Accumulating evidence from epidemiologic and laboratory studies support an inverse relationship between a regular consumption of fruits and vegetables and the risk of specific cancers. Numerous phytochemicals derived from edible plants have been reported to possess ability to interfere with a specific stage of carcinogenic process. Multiple mechanisms have been proposed to account for the anti-carcinogenic actions of dietary constituents, but more attention has recently focussed on intracellular signaling cascades as common molecular targets of a wide variety of chemopreventive phytochemicals.

Citations

Citations to this article as recorded by

Role of natural products in breast cancer related symptomology: Targeting chronic inflammation
Kristina Andrijauskaite, Michael J. Wargovich
Seminars in Cancer Biology.2022; 80: 370. CrossRef
Mechanism of Anti-Cancer Activity of Curcumin on Androgen-Dependent and Androgen-Independent Prostate Cancer
Nurul Azwa Abd. Wahab, Nordin H. Lajis, Faridah Abas, Iekhsan Othman, Rakesh Naidu
Nutrients.2020; 12(3): 679. CrossRef
Morin enhances auranofin anticancer activity by up‐regulation of DR4 and DR5 and modulation of Bcl‐2 through reactive oxygen species generation in Hep3B human hepatocellular carcinoma cells
Hyun Hwang‐Bo, Won Sup Lee, Arulkumar Nagappan, Hong Jae Kim, Radha Panchanathan, Cheol Park, Seong‐Hwan Chang, Nam Deuk Kim, Sun‐Hee Leem, Young‐Chae Chang, Taeg Kyu Kwon, Jae Hun Cheong, Gon Sup Kim, Jin‐Myung Jung, Sung Chul Shin, Soon Chan Hong, Yung
Phytotherapy Research.2019; 33(5): 1384. CrossRef
Anti-neuroinflammatory effect of 6,8,1′-tri- O -methylaverantin, a metabolite from a marine-derived fungal strain Aspergillus sp., via upregulation of heme oxygenase-1 in lipopolysaccharide-activated microglia
Kwan-Woo Kim, Hye Jin Kim, Jae Hak Sohn, Joung Han Yim, Youn-Chul Kim, Hyuncheol Oh
Neurochemistry International.2018; 113: 8. CrossRef
Quercetin and its metabolites protect hepatocytes against ethanol-induced oxidative stress by activation of Nrf2 and AP-1
Yoo-Jung Lee, Song-Yi Beak, Inho Choi, Jung-Suk Sung
Food Science and Biotechnology.2018; 27(3): 809. CrossRef
Role of EGCG in Containing the Progression of Lung Tumorigenesis – A Multistage Targeting Approach
Sunil Kumar Dhatwalia, Manoj Kumar, Devinder K. Dhawan
Nutrition and Cancer.2018; 70(3): 334. CrossRef
Attenuation of tert-Butyl Hydroperoxide (t-BHP)-Induced Oxidative Damage in HepG2 Cells by Tangeretin: Relevance of the Nrf2–ARE and MAPK Signaling Pathways
Fuqiang Liang, Yajing Fang, Weiwei Cao, Zhuo Zhang, Siyi Pan, Xiaoyun Xu
Journal of Agricultural and Food Chemistry.2018; 66(25): 6317. CrossRef
Asiaticoside Mitigates the Allergic Inflammation by Abrogating the Degranulation of Mast Cells
Jing Zhi Jiang, Jing Ye, Guang Yu Jin, Hong Mei Piao, Hong Cui, Ming Yu Zheng, Jin Shi Yang, Nan Che, Yun Ho Choi, Liang Chang Li, Guang Hai Yan
Journal of Agricultural and Food Chemistry.2017; 65(37): 8128. CrossRef
Resveratrol nanoformulation for cancer prevention and therapy
Imtiaz A. Siddiqui, Vanna Sanna, Nihal Ahmad, Mario Sechi, Hasan Mukhtar
Annals of the New York Academy of Sciences.2015; 1348(1): 20. CrossRef
Pachymic Acid Induces Apoptosis of EJ Bladder Cancer Cells by DR5 Up-Regulation, ROS Generation, Modulation of Bcl-2 and IAP Family Members
Jin-Woo Jeong, Won Sup Lee, Se-il Go, Arulkumar Nagappan, Jun Young Baek, Jae-Dong Lee, Su-Jae Lee, Cheol Park, Gi Young Kim, Hye Jung Kim, Gon-Sup Kim, Taeg Kyu Kwon, Chung Ho Ryu, Sung Chul Shin, Yung Hyun Choi
Phytotherapy Research.2015; 29(10): 1516. CrossRef
Polyphenols Isolated from Allium cepa L. Induces Apoptosis by Induction of p53 and Suppression of Bcl-2 through Inhibiting PI3K/Akt Signaling Pathway in AGS Human Cancer Cells
Won Sup Lee, Sang Mi Yi, Jeong Won Yun, Ji Hyun Jung, Dong Hoon Kim, Hye Jung Kim, Seong-Hwan Chang, GonSup Kim, Chung Ho Ryu, Sung Chul Shin, Soon Chan Hong, Yung Hyun Choi, Jin-Myung Jung
Journal of Cancer Prevention.2014; 19(1): 14. CrossRef
Morin, a Flavonoid from Moraceae, Induces Apoptosis by Induction of BAD Protein in Human Leukemic Cells
Cheol Park, Won Lee, Se-Il Go, Arulkumar Nagappan, Min Han, Su Hong, Gon Kim, Gi Kim, Taeg Kwon, Chung Ryu, Sung Shin, Yung Choi
International Journal of Molecular Sciences.2014; 16(1): 645. CrossRef
Polyphenols isolated from Allium cepa L. induces apoptosis by suppressing IAP-1 through inhibiting PI3K/Akt signaling pathways in human leukemic cells
Min Ho Han, Won Sup Lee, Ji Hyun Jung, Jae-Hun Jeong, Cheol Park, Hye Jung Kim, GonSup Kim, Jin-Myung Jung, Taeg Kyu Kwon, Gi-Young Kim, Chung Ho Ryu, Sung Chul Shin, Soon Chan Hong, Yung Hyun Choi
Food and Chemical Toxicology.2013; 62: 382. CrossRef
Flavonoids from Orostachys japonicus A. Berger Inhibit the Invasion of LnCaP Prostate Carcinoma Cells by Inactivating Akt and Modulating Tight Junctions
Dong Shin, Won Lee, Ji Jung, Su Hong, Cheol Park, Hye Kim, Gi-Young Kim, Hye Hwang, Gon Kim, Jin-Myung Jung, Chung Ryu, Sung Shin, Soon Hong, Yung Choi
International Journal of Molecular Sciences.2013; 14(9): 18407. CrossRef
Expression of NSAID-activated gene-1 by EGCG in head and neck cancer: involvement of ATM-dependent p53 expression
Sung Un Kang, Bok-Soon Lee, Seong-Ho Lee, Seung Joon Baek, Yoo Seob Shin, Chul-Ho Kim
The Journal of Nutritional Biochemistry.2013; 24(6): 986. CrossRef
Identification, Synthesis, and Biological Evaluation of the Metabolites of 3-Amino-6-(3′-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6–36), a Promising Rexinoid Lead Compound for the Development of Cancer Chemotherapeutic and Chemopreventi
Lian Chen, Martin Conda-Sheridan, P. V. Narasimha Reddy, Andrew Morrell, Eun-Jung Park, Tamara P. Kondratyuk, John M. Pezzuto, Richard B. van Breemen, Mark Cushman
Journal of Medicinal Chemistry.2012; 55(12): 5965. CrossRef
Suppression of Nrf2-driven heme oxygenase-1 enhances the chemosensitivity of lung cancer A549 cells toward cisplatin
Hak-Ryul Kim, Sejin Kim, Eun-Jung Kim, Jung-Hyun Park, Sei-Hoon Yang, Eun-Taik Jeong, Channy Park, Myung-Ja Youn, Hong-Seob So, Raekil Park
Lung Cancer.2008; 60(1): 47. CrossRef
Anticancer activity of sodium caffeate and its mechanism1
Feng XU, Sheng-hua ZHANG, Rong-guang SHAO, Yong-su ZHEN
Acta Pharmacologica Sinica.2005; 26(10): 1248. CrossRef

19,578 View
206 Download
18 Crossref

Original Articles

A Phase II Trial of Docetaxel and Ifosfamide for Patients with Platinum-Resistant or Refractory Non-Small Cell Lung Cancer in a Salvage Setting: Gyeong-Won Lee, Jung-Hun Kang, Seok-Hyun Kim, Hea Yong Lee, Ho-Cheol Kim, Won-Sup Lee, Jong-Duk Lee, Young-Sil Hwang, Joung-Soon Jang, Jong-Seok Lee; Cancer Res Treat. 2004;36(5):287-292. Published online October 31, 2004; DOI: https://doi.org/10.4143/crt.2004.36.5.287

Abstract PDF PubReader ePub

Purpose

We conducted a phase II study of docetaxel and ifosfamide chemotherapy for patients with platinum-resistant or refractory non-small-cell lung cancer (NSCLC) to evaluate the response and toxicity profiles as a salvage treatment.

Materials and Methods

Between July 2000 and July 2004, 40 patients who had previously received platinum-based regimen as the first-line or second-line therapy were enrolled in this study. The treatment consisted of a docetaxel 75 mg/m² intravenous infusion on day 1 and intravenous ifosfamide 3 g/m² with Mesna® uroprotectione on day 1 through 3. This regimen was repeated every 3 weeks.

Results

One hundred thirty cycles of treatment were given, with a median of 3 cycles (range: 2~6 cycles). All the patients were evaluable for the response rate and toxicity profile. The major toxicity was myelosuppression. Grade 3~4 neutropenia occurred in 30 patients (75%) during treatment. Febrile neutropenia occurred in 16 patients (40%). Five of 40 patients (12.5%) had a partial response (95% confidence interval, 3.3~21.7%). The median time to disease progression was 2.65 months (range: 2.02~3.20 months), and the median survival was 5.24 months (range: 2.99~7.49 months).

Conclusion

Salvage chemotherapy with docetaxel and ifosfamide showed a low efficacy and a high proportion of severe neutropenia in patients with platinum-resistant or refractory advanced NSCLC.

Citations

Citations to this article as recorded by

The Safety and Efficacy of Second-line Single Docetaxel (75 mg/m2) Therapy in Advanced Non-Small Cell Lung Cancer Patients who were Previously Treated with Platinum-based Chemotherapy
Byoung Yong Shim, Chi Hong Kim, So Hyang Song, Meyung Im Ahn, Eun Jung Hong, Sung Whan Kim, Suzy Kim, Min Seop Jo, Deog Gon Cho, Kyu Do Cho, Jinyoung Yoo, Hoon-Kyo Kim
Cancer Research and Treatment.2005; 37(6): 339. CrossRef

9,456 View
52 Download
1 Crossref

A Phase II Study of Weekly Paclitaxel, Cisplatin and Concurrent Radiation Therapy for Locally-Advanced Unresectable Non-Small Cell Lung Cancer: Early Closure due to Lack of Efficacy: Se Hoon Park, Mi Kyung Kim, Sun Young Kyung, Young-Hee Lim, Chang Hyeok An, Jeong Woong Park, Seong Hwan Jeong, Jae Woong Lee, Kyu Chan Lee, Eun Kyung Cho, Soo Mee Bang, Dong Bok Shin, Jae Hoon Lee; Cancer Res Treat. 2004;36(5):293-297. Published online October 31, 2004; DOI: https://doi.org/10.4143/crt.2004.36.5.293

Abstract PDF PubReader ePub: Purpose
In this phase II study, the efficacy and safety of weekly paclitaxel concomitant with cisplatin and thoracic radiotherapy (TRT) was evaluated in patients with locally-advanced unresectable non-small cell lung cancer (NSCLC).
Materials and Methods
Patients with stage III NSCLC (without pleural effusion or cervical lymphadenopathy) received TRT (63 Gy in 35 fractions over 7 weeks) with concurrent weekly cisplatin 20 mg/m² and paclitaxel 40 mg/m²/week infused over 3 hours. In patients without evidence of disease progression, the administration of a further 2 cycles of consolidation chemotherapy, consisting of paclitaxel 175 mg/m² and cisplatin 75 mg/m², were planned after completion of the TRT.
Results
Between Feb 2000 and Dec 2002, 20 patients were entered into the study; 13 completed all 7 weeks of treatment (median 7.6 weeks; range 3.3 to 9.4). Seven out of 16 (43.8%) objective responses were observed, with 15 (75%) patients experiencing at least one episode of grade 3/4 toxicity. The main toxicities were moderate to severe neutropenia and gastrointestinal toxicity.
Conclusion
The unsatisfactory response rate and the high incidence of grade 3/4 hematologic and non-hematologic toxicities, including 7 early discontinuations of treatment and exceeding the study stopping rules, prompted the early closure of the study. In view of the activity observed, the protocol was amended to protracted continuous infusion paclitaxel, cisplatin and concurrent TRT.

8,375 View
53 Download

Prognostic Significance of CD24 Expression in Gastric Carcinoma: Nevine S. Darwish, Min A Kim, Mee Soo Chang, Hye Seung Lee, Byung Lan Lee, Yong Il Kim, Woo Ho Kim; Cancer Res Treat. 2004;36(5):298-302. Published online October 30, 2004; DOI: https://doi.org/10.4143/crt.2004.36.5.298

Abstract PDF PubReader ePub

Purpose

The human CD24 antigen is a small heavily glycosylated cell surface protein, which is expressed in hematological malignancies, as well as in a large variety of solid tumors. Its expression is now known to be related to the prognosis of several kinds of tumors. This study is designed to examine the prognostic significance of CD24 in Korean gastric cancer patients.

Materials and Methods

In the present study, we examined CD24 expression in 300 consecutive cases of gastric carcinoma by immunohistochemical staining using the tissue-array method. We also investigated the clinicopathological profiles related to CD24 expression.

Results

One hundred and three cases out of 300 (34.3%) showed the positive expression of CD24. The altered expression of CD24 was significantly associated with differentiated cancer (p=0.003), the intestinal subtype according to the Lauren classification (p<0.001), the advanced stage cancer (p=0.027), with lymphatic invasion (p=0.038) and with vascular invasion (p=0.006). The survival analysis revealed that the patients with CD24 positive expression showed significantly poorer survival than those without CD24 expression. Moreover, a combined evaluation revealed that PTEN+/CD24- cases showed the best survival compared to other groups (p=0.01).

Conclusion

Positive CD24 expression occurs in a subset of gastric carcinomas and it correlates significantly with lymphatic invasion, blood vessel invasion and poor survival.

Citations

Citations to this article as recorded by

CD24 blockade as a novel strategy for cancer treatment
Yawen Wang, Haoran Yu, Mengyuan Yu, Hui Liu, Bing Zhang, Yuanyuan Wang, Simin Zhao, Qingxin Xia
International Immunopharmacology.2023; 121: 110557. CrossRef
Emerging Immune Checkpoint Molecules on Cancer Cells: CD24 and CD200
Sun Young Moon, Minjoo Han, Gyoungah Ryu, Seong-Ah Shin, Jun Hyuck Lee, Chang Sup Lee
International Journal of Molecular Sciences.2023; 24(20): 15072. CrossRef
Clinical and prognostic significances of cancer stem cell markers in gastric cancer patients: a systematic review and meta-analysis
Mahdieh Razmi, Roya Ghods, Somayeh Vafaei, Maryam Sahlolbei, Leili Saeednejad Zanjani, Zahra Madjd
Cancer Cell International.2021;[Epub] CrossRef
Exosomes and GPI-anchored proteins: Judicious pairs for investigating biomarkers from body fluids
Michel Vidal
Advanced Drug Delivery Reviews.2020; 161-162: 110. CrossRef
CD24, A Review of its Role in Tumor Diagnosis, Progression and Therapy
Yang-Hong Ni, Xia Zhao, Wei Wang
Current Gene Therapy.2020; 20(2): 109. CrossRef
DNA Aptamers for the Malignant Transformation Marker CD24
Joanna Fafińska, Andreas Czech, Tobias Sitz, Zoya Ignatova, Ulrich Hahn
Nucleic Acid Therapeutics.2018; 28(6): 326. CrossRef
The Identifications and Clinical Implications of Cancer Stem Cells in Colorectal Cancer
S.M. Riajul Wahab, Farhadul Islam, Vinod Gopalan, Alfred King-yin Lam
Clinical Colorectal Cancer.2017; 16(2): 93. CrossRef
Clinicopathological and Prognostic Value of CD24 Expression in Breast Cancer: A Meta-Analysis
Gao Liu, Guo-Xing Liu, Yu Fang, Zhen-Yu Cao, Hui-Hui Du, Jie Fu, Ke Qian
The International Journal of Biological Markers.2017; 32(2): 182. CrossRef
CD24 associates with EGFR and supports EGF/EGFR signaling via RhoA in gastric cancer cells
Wenjie Deng, Luo Gu, Xiaojie Li, Jianchao Zheng, Yujie Zhang, Biao Duan, Jie Cui, Jing Dong, Jun Du
Journal of Translational Medicine.2016;[Epub] CrossRef
CD24 enrichment protects while its loss increases susceptibility of juvenile chondrocytes towards inflammation
Jieun Lee, Piera Smeriglio, Jason Dragoo, William J. Maloney, Nidhi Bhutani
Arthritis Research & Therapy.2016;[Epub] CrossRef
CD44v3+/CD24− cells possess cancer stem cell-like properties in human oral squamous cell carcinoma
KEITA TODOROKI, SACHIKO OGASAWARA, JUN AKIBA, MASAMICHI NAKAYAMA, YOSHIKI NAITO, NAOKO SEKI, JINGO KUSUKAWA, HIROHISA YANO
International Journal of Oncology.2016; 48(1): 99. CrossRef
CD44 and CD24 coordinate the reprogramming of nasopharyngeal carcinoma cells towards a cancer stem cell phenotype through STAT3 activation
Yao-An Shen, Chia-Yu Wang, Hui-Yen Chuang, John Jeng-Jong Hwang, Wei-Hsin Chi, Chih-Hung Shu, Ching-Yin Ho, Wing-Yin Li, Yann-Jang Chen
Oncotarget.2016; 7(36): 58351. CrossRef
CD24 Overexpression Is Associated with Poor Prognosis in Luminal A and Triple-Negative Breast Cancer
Mi Jeong Kwon, Jinil Han, Ji Hyun Seo, Kyoung Song, Hae Min Jeong, Jong-Sun Choi, Yu Jin Kim, Seon-Heui Lee, Yoon-La Choi, Young Kee Shin, Yves St-Pierre
PLOS ONE.2015; 10(10): e0139112. CrossRef
Expression of CD24, p21, p53, and c‐myc in alpha‐fetoprotein‐producing gastric cancer: Correlation with clinicopathologic characteristics and survival
Xiaowen Liu, Hongmei Yu, Hong Cai, Yanong Wang
Journal of Surgical Oncology.2014; 109(8): 859. CrossRef
CD24 mediates gastric carcinogenesis and promotes gastric cancer progression via STAT3 activation
Ying-Chao Wang, Ji-Lin Wang, Xuan Kong, Tian-Tian Sun, Hao-Yan Chen, Jie Hong, Jing-Yuan Fang
Apoptosis.2014; 19(4): 643. CrossRef
CD44 but not CD24 expression is related to poor prognosis in non-cardia adenocarcinoma of the stomach
Xueyuan Cao, Donghui Cao, MeiShan Jin, Zhifang Jia, Fei Kong, Hongxi Ma, Yinping Wang, Jing Jiang
BMC Gastroenterology.2014;[Epub] CrossRef
Hypoxia‐mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion
Nobuaki Fujikuni, Hideki Yamamoto, Kazuaki Tanabe, Yutaka Naito, Naoya Sakamoto, Yuka Tanaka, Kazuyoshi Yanagihara, Naohide Oue, Wataru Yasui, Hideki Ohdan
Cancer Science.2014; 105(11): 1411. CrossRef
Clinicopathological and Prognostic Significance of CD24 Overexpression in Patients with Gastric Cancer: A Meta-Analysis
Jing-Xun Wu, Yuan-Yuan Zhao, Xuan Wu, Han-Xiang An, Yitao Ding
PLoS ONE.2014; 9(12): e114746. CrossRef
Biomarkers for predicting future metastasis of human gastrointestinal tumors
Lui Ng, Ronnie Tung Ping Poon, Roberta Pang
Cellular and Molecular Life Sciences.2013; 70(19): 3631. CrossRef
CD44/CD24 Expression in recurrent gastric cancer: a retrospective analysis
Ching-Shya Yong, Chih-Ming Ou Yang, Yenn-Hwei Chou, Chao-Sheng Liao, Chung-Wei Lee, Chin-Cheng Lee
BMC Gastroenterology.2012;[Epub] CrossRef
PTEN deletion is rare but often homogeneous in gastric cancer
Sormeh Mina, Benjamin A Bohn, Ronald Simon, Antje Krohn, Matthias Reeh, Dirk Arnold, Carsten Bokemeyer, Guido Sauter, Jakob R Izbicki, Andreas Marx, Phillip R Stahl
Journal of Clinical Pathology.2012; 65(8): 693. CrossRef
Prognostic significance of loss of c-fos protein in gastric carcinoma
Seon Pil Jin, Ji Hun Kim, Min A Kim, Han-Kwang Yang, Hee Eun Lee, Hye Seung Lee, Woo Ho Kim
Pathology & Oncology Research.2007; 13(4): 284. CrossRef
Tissue Array Methods for High-throughput Clinicopathologic Research
Hye Seung Lee, Woo Ho Kim
Cancer Research and Treatment.2006; 38(1): 1. CrossRef
Loss of DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs) Expression in Gastric Cancers
Hye Seung Lee, Han-Kwang Yang, Woo Ho Kim, Gheeyoung Choe
Cancer Research and Treatment.2005; 37(2): 98. CrossRef
Cytoplasmic CD24 Expression in Colorectal Cancer Independently Correlates with Shortened Patient Survival
Wilko Weichert, Carsten Denkert, Mick Burkhardt, Tserenchunt Gansukh, Joachim Bellach, Peter Altevogt, Manfred Dietel, Glen Kristiansen
Clinical Cancer Research.2005; 11(18): 6574. CrossRef

9,514 View
61 Download
25 Crossref

Expression of Caspase-3 and c-myc in Non-Small Cell Lung Cancer: Jin young Yoo, Chi Hong Kim, So Hyang Song, Byoung Yong Shim, Youn Ju Jeong, Meyung Im Ahn, Suji Kim, Deog Gon Cho, Min Seop Jo, Kyu Do Cho, Hong Joo Cho, Seok Jin Kang, Hoon Kyo Kim; Cancer Res Treat. 2004;36(5):303-307. Published online October 31, 2004; DOI: https://doi.org/10.4143/crt.2004.36.5.303

Abstract PDF PubReader ePub

Purpose

Caspase-3 is a cysteine protease that plays an important role in the process of apoptotic cell death, but little has been studied clinically on caspase-3 in lung cancer. Increased c-myc expression can result in mitosis or apoptosis, and its contribution to the pathogenesis and prognosis of lung cancer has gained interest. In the present study, the expressions of caspase-3 and c-myc, along with their possible correlations with prognostic variables, were analyzed in resected non-small cell lung carcinomas (NSCLC).

Materials and Methods

Archival tumor tissues from 147 previously untreated NSCLC patients were examined by immunohistochemistry for the expressions of caspase-3 and c-myc proteins. Clinical information was obtained through the computerized retrospective database from the tumor registry.

Results

The expressions of caspase-3 and c-myc were detected in 60 (88/147) and 16% (24/147) of tumors, respectively. No association was found between caspase-3 and c-myc expressions. A multivariate analysis demonstrated the N status and pathologic stage to be significantly correlated with poor survival (p-value=.018 and .002, respectively), but positive expression of caspase-3 was associated with a good prognosis (p=.03).

Conclusion

Our data suggest the involvement of caspase-3 in the tumorigenesis of NSCLC. It is also noteworthy that caspase-3 expression might be a favorable prognostic indicator in these tumors.

Citations

Citations to this article as recorded by

Highly in vitro anti-cancer activity of melittin-loaded niosomes on non-small cell lung cancer cells
Pooyan Honari, Delavar Shahbazzadeh, Mahdi Behdani, Kamran Pooshang Bagheri
Toxicon.2024; 241: 107673. CrossRef
Neuropilin-1 Binding Peptide as Fusion to Diphtheria Toxin Induces Apoptosis in Non-small Cell Lung Cancer Cell Line
Sara Eghtedari, Mahdi Behdani, Fatemeh Kazemi-Lomedasht
Current Pharmaceutical Design.2024; 30(17): 1317. CrossRef
Antiproliferative effect of indeno[1,2-d]thiazolo[3,2-a]pyrimidine analogues on IL-6 mediated STAT3 and role of the apoptotic pathway in albino Wistar rats of ethyl carbamate-induced lung carcinoma: In-silico, In-vitro, and In-vivo study
Archana Bharti Sonkar, Abhishek Verma, Sneha Yadav, Rohit Kumar, Jyoti Singh, Amit K. Keshari, Soniya Rani, Anurag Kumar, Dharmendra Kumar, Neeraj Kumar Shrivastava, Shubham Rastogi, Mariam K. Alamoudi, Mohd Nazam Ansari, Abdulaziz S. Saeedan, Gaurav Kait
Cancer Cell International.2024;[Epub] CrossRef
The Effect of Continuous Positive Airway Pressure (CPAP) Therapy on Serum Caspase-3 Level in Patients with Obstructive Sleep Apnea (OSA)
Mustafa Kemal Kaypak, Ali Nihat Annakkaya, Fatih Davran, Pınar Yıldız Gülhan, Uğur Yüregir
Sleep and Breathing.2024; 28(4): 1597. CrossRef
The Expression of Caspase-3 and GRIM-19 in Non-mucinous Lung Adenocarcinoma and Their Clinicopathologic Significance
Alev OK ATILGAN, Merih TEPEOĞLU, Eda YILMAZ AKÇAY, Leyla HASANALİYEVA, Dalokay KILIÇ, Handan ÖZDEMİR
Düzce Tıp Fakültesi Dergisi.2023; 25(2): 158. CrossRef
Increasing Apoptotic Effect of Cord Blood and Wharton's Jelly-derived Mesenchymal Stem Cells on HT-29
Figen Abatay-Sel, Ayse Erol, Mediha Suleymanoglu, Gokhan Demirayak, Cigdem Kekik-Cinar, Durdane Serap Kuruca, Fatma Savran-Oguz
Current Stem Cell Research & Therapy.2023; 18(8): 1133. CrossRef
Multimolecular characteristics of cell-death related hub genes in human cancers: a comprehensive pan-cancer analysis
Dingtao Hu, Tingyu Zhang, Ziye Yan, Linlin Wang, Yuhua Wang, Nana Meng, Bizhi Tu, Ying Teng, Zhen Li, Xiaoqi Lou, Yu Lei, Xiaoshuang Ren, Yanfeng Zou, Fang Wang
Cell Cycle.2022; 21(22): 2444. CrossRef
Evaluate the Prognosis of MYC/TP53 Comutation in Chinese Patients with EGFR-Positive Advanced NSCLC Using Next-Generation Sequencing: A Retrospective Study
Jin Cao, Juan J Gu, Yichen Liang, Buhai Wang
Technology in Cancer Research & Treatment.2022;[Epub] CrossRef
Global profiling of lncRNAs-miRNAs-mRNAs reveals differential expression of coding genes and non-coding RNAs in the lung of beagle dogs at different stages of Toxocara canis infection
Wen-Bin Zheng, Yang Zou, Jun-Jun He, Hany M. Elsheikha, Guo-Hua Liu, Min-Hua Hu, Shui-Lian Wang, Xing-Quan Zhu
International Journal for Parasitology.2021; 51(1): 49. CrossRef
Prognostic Significance of Eight Immune-Related Genes on Survival in Patients with Lung Squamous Cell Carcinoma
Hansheng Wu, Shujie Huang, Weitao Zhuang, Guibin Qiao
Biomarkers in Medicine.2021; 15(4): 295. CrossRef
Antitumor Effects of Carvacrol and Thymol: A Systematic Review
Laeza Alves Sampaio, Lícia Tairiny Santos Pina, Mairim Russo Serafini, Débora dos Santos Tavares, Adriana Gibara Guimarães
Frontiers in Pharmacology.2021;[Epub] CrossRef
MYC, MYCL, and MYCN as therapeutic targets in lung cancer
Daniel Massó-Vallés, Marie-Eve Beaulieu, Laura Soucek
Expert Opinion on Therapeutic Targets.2020; 24(2): 101. CrossRef
RETRACTED ARTICLE: A facile approach for fabricating CD44-targeted delivery of hyaluronic acid-functionalized PCL nanoparticles in urethane-induced lung cancer: Bcl-2, MMP-9, caspase-9, and BAX as potential markers
Poonam Parashar, Chandra Bhushan Tripathi, Malti Arya, Jovita Kanoujia, Mahendra Singh, Abhishek Yadav, Shubhini A. Saraf
Drug Delivery and Translational Research.2019; 9(1): 37. CrossRef
miR-140-3p functions as a tumor suppressor in squamous cell lung cancer by regulating BRD9
Haitao Huang, Yuxuan Wang, Qin Li, Xiaoyan Fei, Haitao Ma, Rongkuan Hu
Cancer Letters.2019; 446: 81. CrossRef
Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival
Xuan Pu, Sarah J. Storr, Yimin Zhang, Emad A. Rakha, Andrew R. Green, Ian O. Ellis, Stewart G. Martin
Apoptosis.2017; 22(3): 357. CrossRef
MYC expression correlates with PD-L1 expression in non-small cell lung cancer
Eun Young Kim, Arum Kim, Se Kyu Kim, Yoon Soo Chang
Lung Cancer.2017; 110: 63. CrossRef
Caspase-3 expression in tumorigenesis and prognosis of buccal mucosa squamous cell carcinoma
Jer-Shyung Huang, Cheng-Mei Yang, Jyh-Seng Wang, Huei-Han Liou, I-Chien Hsieh, Guan-Cheng Li, Sin-Jhih Huang, Chih-Wen Shu, Ting-Ying Fu, Yun-Chung Lin, Luo-Ping Ger, Pei-Feng Liu
Oncotarget.2017; 8(48): 84237. CrossRef
An epigenetic auto-feedback loop regulates TGF-β type II receptor expression and function in NSCLC
Shanzhong Yang, Yong-Jig Cho, Lin Jin, Guandou Yuan, Arunima Datta, Phillip Buckhaults, Pran K. Datta
Oncotarget.2015; 6(32): 33237. CrossRef
Decoding c-Myc networks of cell cycle and apoptosis regulated genes in a transgenic mouse model of papillary lung adenocarcinomas
Yari Ciribilli, Prashant Singh, Reinhard Spanel, Alberto Inga, Jürgen Borlak
Oncotarget.2015; 6(31): 31569. CrossRef
Suppression of Dicer Increases Sensitivity to Gefitinib in Human Lung Cancer Cells
Jui-Chieh Chen, Yen-Hao Su, Ching-Feng Chiu, Yi-Wen Chang, Yang-Hao Yu, Chi-Feng Tseng, Hsin-An Chen, Jen-Liang Su
Annals of Surgical Oncology.2014; 21(S4): 555. CrossRef
Retracted: MiR‐449c targets c‐Myc and inhibits NSCLC cell progression
Li-Jun Miao, Shi-Fu Huang, Zhen-Tao Sun, Zeng-Yan Gao, Rui-xia Zhang, Ying Liu, Jing Wang
FEBS Letters.2013; 587(9): 1359. CrossRef
The Evaluation of Immunohistochemical Markers and Thymic Cortical Microenvironmental Cells in Distinguishing Thymic Carcinoma from Type B3 Thymoma or Lung Squamous Cell Carcinoma
Atsushi Hayashi, Takumi Fumon, Yukari Miki, Hiaki Sato, Tadashi Yoshino, Kiyoshi Takahashi
Journal of Clinical and Experimental Hematopathology.2013; 53(1): 9. CrossRef
Protein Signature of Lung Cancer Tissues
Michael R. Mehan, Deborah Ayers, Derek Thirstrup, Wei Xiong, Rachel M. Ostroff, Edward N. Brody, Jeffrey J. Walker, Larry Gold, Thale C. Jarvis, Nebojsa Janjic, Geoffrey S. Baird, Sheri K. Wilcox, Rossella Rota
PLoS ONE.2012; 7(4): e35157. CrossRef

10,833 View
70 Download
23 Crossref

Effective Inhibition of Cancer Cell Growth by a Novel Tripartite Transfection Complex Containing Ribbon Antisense Molecules to hTR: Jong-Gu Park; Cancer Res Treat. 2004;36(5):308-314. Published online October 31, 2004; DOI: https://doi.org/10.4143/crt.2004.36.5.308

Abstract PDF PubReader ePub: Purpose
In the present study, ribbon antisense to the hTR RNA, a component of the telomerase complex, was employed to inhibit telomerase activity and cancer cell growth.
Materials and Methods
Ribbon antisense molecules to the human hTR gene (hTR-RiAS) were constructed and complexed with a short modified peptide and cationic liposomes to improve the cellular uptake of the antisense molecules. The DPL complexes containing hTR-RiAS were transfected into target cancer cells. Various assays were performed to confirm the effects of the hTR-RiAS on the gene expression and cell proliferation.
Results
When cancer cells were treated with hTR-RiAS, the cellular level of hTR mRNA was reduced by more than 95%, as shown by RT-PCR. Further, the telomerase acti vity was also affected by the antisense treatment. In contrast, both mismatched and scrambled oligonucleotides failed to reduce the levels of hTR mRNA and telomerase activity. When checked for cancer cell viability, hTR-RiAS inhibited cell growth by more than 70%, in a very rapid manner. The reduced cell viability was found to be due to apoptosis of cancer cells.
Conclusion
These results show that hTR-RiAS is a powerful anticancer reagent, with the potential for broad efficacy to diverse malignant tumors.

7,416 View
42 Download

Activity of Green Tea Polyphenol Epigallocatechin-3-gallate Against Ovarian Carcinoma Cell Lines: Yong Wook Kim, Su Mi Bae, Joon Mo Lee, Sung Eun Namkoong, Sei Jun Han, Byoung Rai Lee, Insu P. Lee, Sang Hee Kim, Young Joo Lee, Chong Kook Kim, Yong-Wan Kim, Woong Shick Ahn; Cancer Res Treat. 2004;36(5):315-323. Published online October 31, 2004; DOI: https://doi.org/10.4143/crt.2004.36.5.315

Abstract PDF PubReader ePub

Purpose

A constituent of green tea, (-)-epigallocatechin-3-gallate (EGCG), is known to possess anti-cancer properties. In this study, the time-course of the anticancer effects of EGCG on human ovarian cancer cells were investigated to provide insights into the molecular-level understanding of the growth suppression mechanism involved in EGCG-mediated apoptosis and cell cycle arrest.

Materials and Methods

Three human ovarian cancer cell lines (p53 negative, SKOV-3 cells; mutant type p53, OVCAR-3 cells; and wild type p53, PA-1 cells) were used. The effect of EGCG treatment was studied via a cell count assay, cell cycle analysis, FACS, Western blot and macroarray assay.

Results

EGCG exerts a significant role in suppressing ovarian cancer cell growth, showed dose dependent growth inhibitory effects in each cell line and induced apoptosis and cell cycle arrest. The cell cycle was arrested at the G1 phase by EGCG in SKOV-3 and OVCAR-3 cells.

In contrast, the cell cycle was arrested in the G1/S phase in PA-1 cells. EGCG differentially regulated the expression of genes and proteins (Bax, p21, Retinoblastoma, cyclin D1, CDK4 and Bcl-X_L) more than 2 fold, showing a possible gene regulatory role for EGCG. The continual expression in p21WAF1 suggests that EGCG acts in the same way with p53 proteins to facilitate apoptosis after EGCG treatment. Bax, PCNA and Bcl-X are also important in EGCG-mediated apoptosis. In contrast, CDK4 and Rb are not important in ovarian cancer cell growth inhibition.

Conclusion

EGCG can inhibit ovarian cancer cell growth through the induction of apoptosis and cell cycle arrest, as well as in the regulation of cell cycle related proteins. Therefore, EGCG-mediated apoptosis could be applied to an advanced strategy in the development of a potential drug against ovarian cancer.

Citations

Citations to this article as recorded by

Epigallocatechin 3-gallate: From green tea to cancer therapeutics
Manzar Alam, Sabeeha Ali, Ghulam Md. Ashraf, Anwar L. Bilgrami, Dharmendra Kumar Yadav, Md. Imtaiyaz Hassan
Food Chemistry.2022; 379: 132135. CrossRef
Synergistic effects of green tea extract and paclitaxel in the induction of mitochondrial apoptosis in ovarian cancer cell lines
Mohammad Panji, Vahideh Behmard, Zahra Zare, Monireh Malekpour, Hasan Nejadbiglari, Saeede Yavari, Tina Nayerpour dizaj, Azadeh Safaeian, Ali Bakhshi, Omid Abazari, Mojtaba Abbasi, Parisa Khanicheragh, Maryam Shabanzadeh
Gene.2021; 787: 145638. CrossRef
A Review on the Biological Activity of Camellia Species
Ana Margarida Teixeira, Clara Sousa
Molecules.2021; 26(8): 2178. CrossRef
Estrogenic biological activity and underlying molecular mechanisms of green tea constituents
Ryoiti Kiyama
Trends in Food Science & Technology.2020; 95: 247. CrossRef
Natural Compounds with Potential to Modulate Cancer Therapies and Self-Reactive Immune Cells
Rhiane Moody, Kirsty Wilson, Anthony Jaworowski, Magdalena Plebanski
Cancers.2020; 12(3): 673. CrossRef
Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer
Saleh A. Almatroodi, Ahmad Almatroudi, Amjad Ali Khan, Fahad A. Alhumaydhi, Mohammed A. Alsahli, Arshad Husain Rahmani
Molecules.2020; 25(14): 3146. CrossRef
The Potential Roles of Epigallocatechin-3-Gallate in the Treatment of Ovarian Cancer: Current State of Knowledge

Sabrina Bimonte, Marco Cascella
Drug Design, Development and Therapy.2020; Volume 14: 4245. CrossRef
Bioinformatics Analysis on Molecular Mechanism of Green Tea Compound Epigallocatechin‐3‐Gallate Against Ovarian Cancer
S Xinqiang, Z Mu, C Lei, LY Mun
Clinical and Translational Science.2017; 10(4): 302. CrossRef
Pharmacological profile of green tea and its polyphenols: a review
Sumit Bansal, Navneet Syan, Pooja Mathur, Shivani Choudhary
Medicinal Chemistry Research.2012; 21(11): 3347. CrossRef
Plant phytochemicals as new potential drugs for immune disorders and cancer therapy: really a promising path?
Salvatore Chirumbolo
Journal of the Science of Food and Agriculture.2012; 92(8): 1573. CrossRef
Green tea for ovarian cancer prevention and treatment: A systematic review of the in vitro, in vivo and epidemiological studies
Dominique Trudel, David P. Labbé, Isabelle Bairati, Vincent Fradet, Laurent Bazinet, Bernard Têtu
Gynecologic Oncology.2012; 126(3): 491. CrossRef
Tea Consumption and Epithelial Ovarian Cancer Risk: A Systematic Review of Observational Studies
Sarah J. Oppeneer, Kim Robien
Nutrition and Cancer.2011; 63(6): 817. CrossRef

10,425 View
64 Download
12 Crossref

Phenylacetate Induces Growth Inhibition and Apoptosis of Human Osteosarcoma Cells: Jong Hyuk Park, Min Young Park, Ho Sung Park, Kyu Yun Jang, Myoung Ja Chung, Woo Sung Moon, Dong Geun Lee, Myoung Jae Kang; Cancer Res Treat. 2004;36(5):324-329. Published online October 31, 2004; DOI: https://doi.org/10.4143/crt.2004.36.5.324

Abstract PDF PubReader ePub

Purpose

Phenylacetate has potent antiproliferative effects in many malignant tumors. However, the exact mechanism as to how phenylacetate induces cell growth arrest remains unclear and very little is known about its effects on human osteosarcoma cells. In this study, we investigated whether phenylacetate is effective against two osteosarcoma cell lines (HOS and U-2 OS) in vitro.

Materials and Methods

The viability of phenylacetate-treated cell lines was assessed by trypan blue exclusion assay, and the cell cycle distribution was measured by flow cytometry. To measure cell apoptosis, poly (ADP-ribose) polymerase cleavage assay and flow cytometry were employed. The expressions of cell cycle-regulatory proteins and the apoptosis-related genes were evaluated by western blot analysis.

Results

Phenylacetate was found to inhibit the growth of osteosarcoma cells, induce cell cycle arrest in the G1 phase, and induce apoptosis. A significant decrease in Bcl-2 expression and a mild up-regulation of Bax were also observed in both phenylacetate-treated cell lines. Reduced phosphorylation of the pRb and the increased expression of p21^Cip1 were observed subsequent to treatment with phenylacetate.

Conclusion

These findings support the idea that phenylacetate may be an effective chemotherapeutic agent to be employed in the future against osteosarcoma, because phenylacetate acts to inhibit the growth of osteosarcoma cells through cell cycle arrest and apoptosis.

Citations

Citations to this article as recorded by

Evaluation of α-hydroxycinnamic acids as pyruvate carboxylase inhibitors
Daniel J. Burkett, Brittney N. Wyatt, Mallory Mews, Anson Bautista, Ryan Engel, Chris Dockendorff, William A. Donaldson, Martin St. Maurice
Bioorganic & Medicinal Chemistry.2019; 27(18): 4041. CrossRef

8,891 View
45 Download
1 Crossref

Dexamethasone Inhibits TRAIL- and Anti-cancer Drugs-induced Cell Death in A549 Cells through Inducing NF-κB-independent cIAP2 Expression: Youn Seup Kim, Jae Seuk Park, Young Koo Jee, Kye Young Lee; Cancer Res Treat. 2004;36(5):330-337. Published online October 31, 2004; DOI: https://doi.org/10.4143/crt.2004.36.5.330

Abstract PDF PubReader ePub

Purpose

We have examined that dexamethasone inhibits apoptotic cell death of A549 lung epithelial cells through TRAIL and anti-cancer drugs. The purpose of the study is to determine the roles of GR, cIAP and NF-κB in this mechanism.

Materials and Methods

In the A549 lung epithelial cell line, TRAIL, taxol, doxorubicine & gemcitabine were used to investigate cell toxicity. Cells were pretreated 12 hours in advance with dexamethasone. RU486 was pretreated 30 minutes before dexamethasone. Crystal violet assay was used for cell toxicity tests. Apoptosis assay was performed by taking morphologic surveys with fluorescent microscopy after double staining with Hoechst 33342 & propium iodide. RT-PCR was used to investigate the gene expression of cIAP1 & cIAP2 by dexamethasone. Ad-IκB α-SR transduction study was used for the role of NF-κB.

Results

TRAIL and anti-cancer drug-induced apoptosis was partially suppressed in A549 cells pretreated with dexamethasone. The inhibitory effect on cell death disappeared in A549 cells pretreated with RU486. Using RT-PCR, changes of cIAP1 and cIAP2 genes manifestation in A549 cells subsequent to pretreatment with dexamethasone were examined. The results showed an increase in cIAP2 expression during a course of time which was suppressed by RU486 pretreatment. Induction of cIAP2 expression changes by dexamethasone was uniquely observed despite the blockade of NF-κB by Ad-IκBα-SR transduction.

Conclusions

These results suggest that dexamethasone inhibits TRAIL- and anti-cancer drug-induced apoptosis in A549 cells by inducing cIAP2 gene expression through a GR-mediated, NF-κB-independent pathway.

Citations

Citations to this article as recorded by

Differential regulation of BIRC2 and BIRC3 expression by inflammatory cytokines and glucocorticoids in pulmonary epithelial cells
Andrew Thorne, Akanksha Bansal, Amandah Necker-Brown, Mahmoud M. Mostafa, Alex Gao, Andrei Georgescu, Cora Kooi, Richard Leigh, Robert Newton, Aristóbolo M. Silva
PLOS ONE.2023; 18(6): e0286783. CrossRef
Soluble CD93 in allergic asthma
Hye Jung Park, Eun-Yi Oh, Hee-Jae Han, Kyung Hee Park, Kyoung-Yong Jeong, Jung-Won Park, Jae-Hyun Lee
Scientific Reports.2020;[Epub] CrossRef
Investigation of New Benzimidazole Derivative Compounds’ Effects on A549 Cell Line
Gülay Gülbol Duran, Meral Urhan Küçük, Öztekin Algül, Menderes Yusuf Terzi
Brazilian Archives of Biology and Technology.2020;[Epub] CrossRef
Glucocorticoid-dependent expression of IAP participates in the protection against TNF-mediated cytotoxicity in MCF7 cells
Irma B. Mitre-Aguilar, Tonatiuh Barrios-Garcia, Victor M. Ruiz-Lopez, Alberto J. Cabrera-Quintero, Nancy R. Mejia-Dominguez, Jose L. Ventura-Gallegos, Daniel Moreno-Mitre, Alejandro Aranda-Gutierrez, Janini Mejia-Rangel, Alma R. Escalona-Guzman, Yanin Cha
BMC Cancer.2019;[Epub] CrossRef
Epigenetic and Glucocorticoid Receptor-Mediated Regulation of Glutathione Peroxidase 3 in Lung Cancer Cells
Byung Chull An, Nak-Kyun Jung, Chun Young Park, In-Jae Oh, Yoo-Duk Choi, Jae-Il Park, Seung-won Lee
Molecules and Cells.2016; 39(8): 631. CrossRef
NK1 receptor antagonists and dexamethasone as anticancer agents in vitro and in a model of brain tumours secondary to breast cancer
Kate M. Lewis, Elizabeth Harford-Wright, Robert Vink, Mounir N. Ghabriel
Anti-Cancer Drugs.2013; 24(4): 344. CrossRef
Glucocorticoid Receptor and Histone Deacetylase–2 Mediate Dexamethasone-Induced Repression of MUC5AC Gene Expression
Yajun Chen, Alan M. Watson, Chad D. Williamson, Michael Rahimi, Chong Liang, Anamaris M. Colberg-Poley, Mary C. Rose
American Journal of Respiratory Cell and Molecular Biology.2012; 47(5): 637. CrossRef

11,154 View
74 Download
7 Crossref

Case Report

Three Cases of Synchronous Solid Tumor and Multiple Myeloma: Sang Hoon Ji, Joon Oh Park, Jeeyun Lee, Mi Jung Oh, Do Hyoung Lim, Byeong-Bae Park, Keun Woo Park, Se-Hoon Lee, Kihyun Kim, Won Seog Kim, Chul Won Jung, Young Suk Park, Young-Hyuck Im, Won Ki Kang, Mark H Lee, Keunchil Park; Cancer Res Treat. 2004;36(5):338-340. Published online October 31, 2004; DOI: https://doi.org/10.4143/crt.2004.36.5.338

Abstract PDF PubReader ePub

The association between a multiple myeloma and a secondary solid tumor is not well established. Some reports showed an increased risk of secondary solid neoplasms in multiple myeloma patients, but others have not. Three cases of the synchronous occurrence of multiple myelomas and solid tumors, namely, a small cell carcinoma of the lung, an adenocarcinoma of the colon and a squamous carcinoma of the pyriform sinus were experienced at our hospital. Therefore, herein is reported the clinical courses and treatment results. The stage of multiple myeloma was Durie-Salmon stage I in all of three cases; therefore, the solid tumors were treated as a primary target because the prognosis of early stage multiple myeloma is generally better than that of advanced solid tumor, while a smoldering or stage I myeloma do not need primary therapy until progression of the multiple myeloma. Two patients died of their solid tumors, but one patient is alive.

Citations

Citations to this article as recorded by

Three-year progression-free survival of a patient with concomitant mucinous adenocarcinoma of the colon with peritoneal dissemination and multiple myeloma who received lenalidomide: a case report
Koki Tamai, Hajime Hirose, Yo Akazawa, Yukihiro Yoshikawa, Masatoshi Nomura, Hiroshi Takeyama, Masahiro Tokunaga, Mitsuyoshi Tei, Shu Okamura, Yusuke Akamaru
Surgical Case Reports.2024;[Epub] CrossRef
The importance of oncological alertness in the differential diagnosis of inflammatory changes in the lungsdetected as a result of differential diagnosis of pneumonia
M. F. Petrukhnova, O. O. Voronkova, O. E. Buyanova, O. N. Antyufeeva, A. E. Kamalova, M. V. Kozhevnikova, I. S. Ilgisonis, Yu. N. Belenkov
Meditsinskiy sovet = Medical Council.2024; (9): 100. CrossRef
Synchronous multiple myeloma and lung adenocarcinoma: A clinical series
Fang Ye, Huan Wang, Ningning Li, Aijun Liu, Wenming Chen
Indian Journal of Pathology and Microbiology.2024; 67(2): 390. CrossRef
Simultaneous multiple myeloma and non‑small cell lung carcinoma: A case report and review of the literature
Huan-Huan Dong, Jing Li, Lin Kang, Qiang Wei, Yan Li
Oncology Letters.2022;[Epub] CrossRef
Rapid progression of gastric cancer with liver metastasis after discontinuation of lenalidomide in a patient with concurrent multiple myeloma: A case report
Naoto Ujiie, Yoshitaka Enomoto, Naruhito Takido, Yasushi Kawaharada, Masashi Zuguchi, Yosuke Kubota
International Journal of Surgery Case Reports.2021; 81: 105834. CrossRef
Bortezomib combined with lenalidomide as the first-line treatment for the rare synchronous occurrence of multiple myeloma and pulmonary adenocarcinoma
Wenli Zuo, Xinghu Zhu, Jingke Yang, Zhenyang Mei, Mei Deng, Quande Lin, Yongping Song, Qingsong Yin
Medicine.2017; 96(1): e5787. CrossRef
Drastic Response to Nivolumab in a Case Demonstrating a Rapid Recurrence of Pulmonary Pleomorphic Carcinoma That Developed After Chemotherapy for Comorbid Myeloma Kidney
Aya Yamamoto, Takashi Iwata, Koji Hashimoto
Haigan.2017; 57(7): 849. CrossRef
Challenges in managing a patient with multiple primary malignancies
Nataliya Mar, David Askin, Jerry George, Colette Spaccavento, Robert Graham, Lynn Ratner
Community Oncology.2012; 9(12): 377. CrossRef
¿Asociación entre colangiocarcinoma y mieloma múltiple?
Laura Gómez-Escolar Viejo, Gema Soler Sala, Vanessa Castaño Giraldo, José María Palazón Azorín, Miguel Pérez-Mateo Regadera
Gastroenterología y Hepatología.2008; 31(6): 402. CrossRef
Synchronous Presentation of Multiple Myeloma and Lung Cancer
Rishu Agarwal, Ritu Gupta, Archana Bhaskar, Atul Sharma, Sanjay Thulkar, Lalit Kumar
Journal of Clinical Oncology.2008; 26(35): 5814. CrossRef

10,094 View
54 Download
10 Crossref

First
Prev
Page of 1
Next
Last

Previous issues