VEGF Expression and MVD in Ductal Carcinoma of Breast

Jeong,  Seong Jon; Park,  Sung Jun; Cha,  Sung Jae; Park,  Young Kum; Chi,  Kyong Choun; Lim,  Hyun Mook; Park,  Sung II; Lee,  Tae Jin; Park,  Un Sub

J Korean Cancer Assoc > Volume 31(6); 1999 > Article

Original Article

Journal of the Korean Cancer Association 1999;31(6): 1168-1178.

VEGF Expression and MVD in Ductal Carcinoma of Breast

Seong Jon Jeong, Sung Jun Park, Sung Jae Cha, Young Kum Park, Kyong Choun Chi, Hyun Mook Lim, Sung II Park, Tae Jin Lee, Un Sub Park

¹Department of General Surgery, College of Medicine Chung Ang University, Seoul, Korea.
²Department of Pathology, College of Medicine Chung Ang University, Seoul, Korea.

ABSTRACT

PURPOSE:
This study was aimed to determine the role of the VEGF and MVD expression in infiltrating ductal carcinoma of breast and to observe the correlation between the expression of these VEGF/MVD, and other prognostic factors.
MATERIALS AND METHODS:
Immunohistochemical staining of VEGF and MVD with monoclonal antibody in pathologic specimens of 35 patients of infiltrating ductal carcinoma of breast was carried out. Reiationship between the expression of the VEGF/MVD and prognostic factors were assessed.
RESULTS:
The VEGF/MVD expression was closely related to tumor size, lymph node metastasis, and clinical stage, but not related to histologic grade, nuclear grade, estrogen receptor, and progestrone receptor. And the VEGF expression was closely related to MVD.
CONCLUSION:
The VEGF expression and microvessel density in infiltrating ductal carcinoma of breast may play an important prognostic factors, closely related to the tumor size, lymph node metastasis, and stage.

Key words: Breast carcinoma;VEGF;Microvessel density