p27Kipl, K-67 and Bcl-2 Expression in Adenoid Cystic Carcinoma of Head and Neck

Choi,  C S; Choi,  G; Song,  J J; Hwang,  K S; Jung,  K Y; Choi,  J O

J Korean Cancer Assoc > Volume 32(2); 2000 > Article

Original Article

Journal of the Korean Cancer Association 2000;32(2): 382-389.

p27Kipl, K-67 and Bcl-2 Expression in Adenoid Cystic Carcinoma of Head and Neck

C S Choi, G Choi, J J Song, K S Hwang, K Y Jung, J O Choi

ABSTRACT

PURPOSE:
p27Kip1 negatively regulates cell proliferation by mediating cell cycle arrest in Gl and Ki-67 is a reliable cellular proliferative index. Also Bcl-2, an inhibitor of apoptosis, has potential activity toward cell survival. The present study investigated p27Kip1, Ki-67 and Bcl-2 expression in adenoid cystic carcinoma for their usefulness of indicator in tumor progression and aggressiveness.
MATERIALS AND METHODS:
Formalin-fixed paraffin-embedded surgical specimens were obtained from seventeen patients with adenoid cystic carcinoma. We performed immunohistochemical staining with p27Kip1, Ki-67 and Bcl-2 monoclonal antibodies and compared with patients clinicopathologic features.
RESULTS:
There were significant correlation between low p27Kip1 expression and high grade and T classification, positive nodal status and perineural invasion and high stages. However, Ki-67 and Bcl-2 expression had no significant differences in clinicopathologic features and p27Kip1 expression.
CONCLUSION:
p27Kip1 is a good reliable marker of tumor progression and aggressiveness in adenoid cystic carcinomas.

Key words: Head and neck neoplasm adenoid cystic carcinoma;p27Kip1;Ki-67;Bcl-2