| No Association between Catalase Gene Polymorphism and Gastric Carcinoma and Hepatocellular Carcinoma in Koreans |
| Ji Hyun Lee, Ran Young Park, Chang Soo Lee, Euh Jun Jeoung, Su Youn Nam, Jae Gun Lee, Kye Young Han, Hee Jae Lee, Joo Ho Chung, Yun Gul Ahn, Sung Vin Yim, Jae Young Cho, Yeon Hee Park |
1Department of Internal Medicine, Kangnam General HospitalPublic Corporation, Seoul, Korea.
2Department of Orthopaedic Surgery, College of Medicine,Kangwon National University, Chuncheon, Korea.
3Kohwang Medical Research Institute, College of Medicine,Kyung Hee University, Seoul, Korea.
4Department of Pharmacology, College of Medicine, KangwonNational University, Chuncheon, Korea.
5Department of Anatomy, College of Medicine, Seoul NationalUniversity, Korea.
6Division of Medical Oncology, Korea Cancer Center Hospital,Seoul, Korea. yhpark@kcch.re.kr
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Published online: December 31, 2002. |
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| ABSTRACT |
PURPOSE:
Oxidative stress has been implicated in the pathogenesis of various diseases. Catalase is one of the main defense mechanisms against oxidative stress. To examine the possible relationship between oxidative stress, and gastric and hepatocellular carcinomas, HinfI restriction length polymorphism (RFLP) in the human catalase gene was assessed.
MATERIALS AND METHODS:
The genotype and allele frequencies in the promoter region of the catalase gene were studied by PCR-RFLP in 108 Korean controls, 80 Korean gastric carcinoma (GC) and 106 Korean hepatocellular carcinoma (HCC) patients.
RESULTS:
No statistically significant differences were found in the genotypic distribution and allelic frequencies between the controls and both types of carcinoma patient.
CONCLUSION:
To address the possible contribution of oxidative stresses to the pathogenesis of gastric and hepatocellular carcinomas, the associations between the catalase gene polymorphism and GC and HCC susceptibilities were studied. As a result, the catalase gene polymorphism was found not to be determinant of GC and HCC susceptibilities. Further studies are required on various other oxidative stress related genes to elucidate the mechanisms of GC and HCC. |
| Key words:
Gastric carcinoma;Hepatocellular carcinoma;Catalase;Polymorphism;PCR-RFLP;Oxidative stress |
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