Immunological Studies on the Antitumor Component of Lyophyllum decastes ( 2 )

Lee, Chang Ock; Choi, Eung Chil; Kim, Byong Kak

J Korean Cancer Assoc > Volume 19(2); 1987 > Article

Original Article

Journal of the Korean Cancer Association 1987;19(2): 57-63.

Lyophyllum decastes 의 항암성분의 면도학적 연구 ( 2 )

이정옥, 최응칠, 김병각

Immunological Studies on the Antitumor Component of Lyophyllum decastes ( 2 )

Chang Ock Lee, Eung Chil Choi, Byong Kak Kim

ABSTRACT

Lyophyllan A was isolated as an antitumor component from Lyophyllum decstes. To elucidate mechanisms of its antitumor activity, its effects on immune response were examined. Lyophyllan A restored the suppressed delayed-type hypersensitivity reaction in tumor-bearing mice up to 85.7% of the normal level. Also lyophyllan A enhanced in vivo generation of cytotoxic T-lymphocytes. When effects of lyophyllan A on natural killer cells that are one of the important nonspecific evvector cells were examined, it augmented natural killer activity in the spleen cells of mice. These results showed that lyophyllan A is an immunopotentiator.