| 소화기계 악성종양 환자에서 혈청 CEA 와 혈청 CA 19-9 의 임상적 의의에 관한 연구 |
| 정영환, 홍성원, 이진오, 홍성운 |
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| Clinical Significance of Serum CEA and Serum AC 19-9 in the Patients with Various Gastrointestinal Malignancy |
| Young Hwan Chung, Weon Seon Hong, Jhin Oh Lee, Seong Woon Hong |
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| ABSTRACT |
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To evaluate the clinical significance of the serum CEA and CA 19-9 in the patients with various gastrointestinal malignancy, serum CEA and serum CA 19-9 were measured by radioimmunoassay in the 113 patients with various gastrointestinal malignancy, who visited Korea Cancer Center Hospital from April, 1985 to Oct, 1985. The result were as follows; 1) The mean serum CEA level in the controls was 2. 9-1. 3 ng/ml, On the other hand, the mean serum CA 19-9 was S. 4+2. 7 U/ml. 2) Four out of 14 patients with benign gastrointestinal disorders showed elevated serum CEA level above the normal upper limit. On the other hand, one out of 14 patients with benign disorders showed elevated serum CA lg-g level above the normal upper limit. 3) In 113 patients with various gastrointestinal malignancy, 26 percent of the patients showed elevated serum CEA level, and 45 percent of the patients showed elevated serum CA 19-9 above the normal upper limit. 4) The sensitivity of serum CEA related to resectability in the stamach and colorectal malignancy were 22% in resectable cases, and 45% in unresectable cases, respectively(p<0.05). On the other hand, the sensitivity of serum CA 19-9 were 29% in resectable cases, and 65% in unresectable cases, respectively(p<0.05). 5) In 25 patients with primary liver carcinoma, there was no significant difference between the high alpha fetoprotein and low alpha fetoproein groups in the serum CA 19-9 level. 6) There was no relationship between the serum CEA and CA 19-9 in the patient with various astrointestinal malignancy. According to the above results, we concluded that 1) serum CA 19-9 radioimmunoassay is a useful tumor marker in the various gastrointestinal malignancy, compared with serum CEA, 2) simultaneous measurement of serum CEA and CA 19-9 is helpful in the diagnosis of various gastrointestinal malignancy, and 3) further careful monitoring of serial serum CA 19-9 in necessary in the treatment of various gastrointestinal malignancy. |
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